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Patent code US10308662

Compile Data Set for Download or QSAR
Found 114 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
BRD4 bromodomain 2


(Homo sapiens (Human))
BDBM50427490
PNG
(CHEMBL2322246 | US10308662, Compound 10 | US950578...)
Show SMILES O=c1cc(oc2ccsc12)N1CCOCC1
Show InChI InChI=1S/C11H11NO3S/c13-8-7-10(12-2-4-14-5-3-12)15-9-1-6-16-11(8)9/h1,6-7H,2-5H2
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US Patent
n/an/a>0n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 2


(Homo sapiens (Human))
BDBM259885
PNG
(US10308662, Compound 126 | US9505780, 126)
Show SMILES Brc1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C11H10BrNO3S/c12-7-6-17-11-8(14)5-9(16-10(7)11)13-1-3-15-4-2-13/h5-6H,1-4H2
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n/an/a>0n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 1


(Homo sapiens (Human))
BDBM50427490
PNG
(CHEMBL2322246 | US10308662, Compound 10 | US950578...)
Show SMILES O=c1cc(oc2ccsc12)N1CCOCC1
Show InChI InChI=1S/C11H11NO3S/c13-8-7-10(12-2-4-14-5-3-12)15-9-1-6-16-11(8)9/h1,6-7H,2-5H2
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n/an/a>0n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 1


(Homo sapiens (Human))
BDBM259885
PNG
(US10308662, Compound 126 | US9505780, 126)
Show SMILES Brc1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C11H10BrNO3S/c12-7-6-17-11-8(14)5-9(16-10(7)11)13-1-3-15-4-2-13/h5-6H,1-4H2
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n/an/a>0n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50427456
PNG
(CHEMBL2326953 | US10308662, Compound 44 | US950578...)
Show SMILES COC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C19H17NO5S/c1-23-19(22)13-4-2-12(3-5-13)14-11-26-18-15(21)10-16(25-17(14)18)20-6-8-24-9-7-20/h2-5,10-11H,6-9H2,1H3
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Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50427485
PNG
(CHEMBL2326959 | US10308662, Compound 120 | US95057...)
Show SMILES O=C(Nc1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1)c1ccncc1
Show InChI InChI=1S/C23H19N3O4S/c27-19-13-20(26-9-11-29-12-10-26)30-21-18(14-31-22(19)21)15-1-3-17(4-2-15)25-23(28)16-5-7-24-8-6-16/h1-8,13-14H,9-12H2,(H,25,28)
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n/an/a 21n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50427457
PNG
(CHEMBL2326952 | US10308662, Compound 25 | US950578...)
Show SMILES CCOC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C20H19NO5S/c1-2-25-20(23)14-5-3-13(4-6-14)15-12-27-19-16(22)11-17(26-18(15)19)21-7-9-24-10-8-21/h3-6,11-12H,2,7-10H2,1H3
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n/an/a 27n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 1


(Homo sapiens (Human))
BDBM50365262
PNG
( (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10124009, C...)
Show SMILES Cc1nnc2[C@H](CC(=O)OC(C)(C)C)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1
Show InChI InChI=1/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/s2
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n/an/a 27.1n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
PI3-kinase class I


(Homo sapiens (Human))
BDBM50427453
PNG
(CHEMBL2322228 | US10308662, Compound 28 | US950578...)
Show SMILES O=c1cc(oc2c(csc12)-c1ccc2OCCOc2c1)N1CCOCC1
Show InChI InChI=1S/C19H17NO5S/c21-14-10-17(20-3-5-22-6-4-20)25-18-13(11-26-19(14)18)12-1-2-15-16(9-12)24-8-7-23-15/h1-2,9-11H,3-8H2
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n/an/a 34n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 2


(Homo sapiens (Human))
BDBM50365262
PNG
( (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10124009, C...)
Show SMILES Cc1nnc2[C@H](CC(=O)OC(C)(C)C)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1
Show InChI InChI=1/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/s2
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n/an/a 39.1n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM259879
PNG
(US10308662, Compound 118 | US9505780, 118)
Show SMILES ONC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C18H16N2O5S/c21-14-9-15(20-5-7-24-8-6-20)25-16-13(10-26-17(14)16)11-1-3-12(4-2-11)18(22)19-23/h1-4,9-10,23H,5-8H2,(H,19,22)
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Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
PI3-kinase class I


(Homo sapiens (Human))
BDBM50427488
PNG
(CHEMBL2326956 | US10308662, Compound 100 | US95057...)
Show SMILES OC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C18H15NO5S/c20-14-9-15(19-5-7-23-8-6-19)24-16-13(10-25-17(14)16)11-1-3-12(4-2-11)18(21)22/h1-4,9-10H,5-8H2,(H,21,22)
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n/an/a 55.2n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
PI3-kinase class I


(Homo sapiens (Human))
BDBM259879
PNG
(US10308662, Compound 118 | US9505780, 118)
Show SMILES ONC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C18H16N2O5S/c21-14-9-15(20-5-7-24-8-6-20)25-16-13(10-26-17(14)16)11-1-3-12(4-2-11)18(22)19-23/h1-4,9-10,23H,5-8H2,(H,19,22)
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n/an/a 90n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
PI3-kinase class I


(Homo sapiens (Human))
BDBM50427485
PNG
(CHEMBL2326959 | US10308662, Compound 120 | US95057...)
Show SMILES O=C(Nc1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1)c1ccncc1
Show InChI InChI=1S/C23H19N3O4S/c27-19-13-20(26-9-11-29-12-10-26)30-21-18(14-31-22(19)21)15-1-3-17(4-2-15)25-23(28)16-5-7-24-8-6-16/h1-8,13-14H,9-12H2,(H,25,28)
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n/an/a 95n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
PI3-kinase class I


(Homo sapiens (Human))
BDBM50427476
PNG
(CHEMBL2322247 | US10308662, Compound 11 | US950578...)
Show SMILES Nc1cccc(c1)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C17H16N2O3S/c18-12-3-1-2-11(8-12)13-10-23-17-14(20)9-15(22-16(13)17)19-4-6-21-7-5-19/h1-3,8-10H,4-7,18H2
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n/an/a 154n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50427453
PNG
(CHEMBL2322228 | US10308662, Compound 28 | US950578...)
Show SMILES O=c1cc(oc2c(csc12)-c1ccc2OCCOc2c1)N1CCOCC1
Show InChI InChI=1S/C19H17NO5S/c21-14-10-17(20-3-5-22-6-4-20)25-18-13(11-26-19(14)18)12-1-2-15-16(9-12)24-8-7-23-15/h1-2,9-11H,3-8H2
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n/an/a 158n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 1


(Homo sapiens (Human))
BDBM259879
PNG
(US10308662, Compound 118 | US9505780, 118)
Show SMILES ONC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C18H16N2O5S/c21-14-9-15(20-5-7-24-8-6-20)25-16-13(10-26-17(14)16)11-1-3-12(4-2-11)18(22)19-23/h1-4,9-10,23H,5-8H2,(H,19,22)
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n/an/a 193n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM50427453
PNG
(CHEMBL2322228 | US10308662, Compound 28 | US950578...)
Show SMILES O=c1cc(oc2c(csc12)-c1ccc2OCCOc2c1)N1CCOCC1
Show InChI InChI=1S/C19H17NO5S/c21-14-10-17(20-3-5-22-6-4-20)25-18-13(11-26-19(14)18)12-1-2-15-16(9-12)24-8-7-23-15/h1-2,9-11H,3-8H2
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Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 1


(Homo sapiens (Human))
BDBM259890
PNG
(US10308662, Compound 131 | US9505780, 131)
Show SMILES Cc1n[nH]c2cc(ccc12)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C19H17N3O3S/c1-11-13-3-2-12(8-15(13)21-20-11)14-10-26-19-16(23)9-17(25-18(14)19)22-4-6-24-7-5-22/h2-3,8-10H,4-7H2,1H3,(H,20,21)
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n/an/a 231n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 2


(Homo sapiens (Human))
BDBM259879
PNG
(US10308662, Compound 118 | US9505780, 118)
Show SMILES ONC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C18H16N2O5S/c21-14-9-15(20-5-7-24-8-6-20)25-16-13(10-26-17(14)16)11-1-3-12(4-2-11)18(22)19-23/h1-4,9-10,23H,5-8H2,(H,19,22)
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n/an/a 235n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 1


(Homo sapiens (Human))
BDBM50427453
PNG
(CHEMBL2322228 | US10308662, Compound 28 | US950578...)
Show SMILES O=c1cc(oc2c(csc12)-c1ccc2OCCOc2c1)N1CCOCC1
Show InChI InChI=1S/C19H17NO5S/c21-14-10-17(20-3-5-22-6-4-20)25-18-13(11-26-19(14)18)12-1-2-15-16(9-12)24-8-7-23-15/h1-2,9-11H,3-8H2
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n/an/a 241n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 1


(Homo sapiens (Human))
BDBM259880
PNG
(US10308662, Compound 121 | US9505780, 121)
Show SMILES Fc1ccc(C(=O)Nc2ccc(cc2)-c2csc3c2oc(cc3=O)N2CCOCC2)c(Nc2ccc(I)cc2F)c1F
Show InChI InChI=1S/C30H21F3IN3O4S/c31-21-7-6-19(27(26(21)33)36-23-8-3-17(34)13-22(23)32)30(39)35-18-4-1-16(2-5-18)20-15-42-29-24(38)14-25(41-28(20)29)37-9-11-40-12-10-37/h1-8,13-15,36H,9-12H2,(H,35,39)
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n/an/a 255n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50427488
PNG
(CHEMBL2326956 | US10308662, Compound 100 | US95057...)
Show SMILES OC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C18H15NO5S/c20-14-9-15(19-5-7-23-8-6-19)24-16-13(10-25-17(14)16)11-1-3-12(4-2-11)18(21)22/h1-4,9-10H,5-8H2,(H,21,22)
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n/an/a 259n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 1


(Homo sapiens (Human))
BDBM50427457
PNG
(CHEMBL2326952 | US10308662, Compound 25 | US950578...)
Show SMILES CCOC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C20H19NO5S/c1-2-25-20(23)14-5-3-13(4-6-14)15-12-27-19-16(22)11-17(26-18(15)19)21-7-9-24-10-8-21/h3-6,11-12H,2,7-10H2,1H3
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n/an/a 277n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50427488
PNG
(CHEMBL2326956 | US10308662, Compound 100 | US95057...)
Show SMILES OC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C18H15NO5S/c20-14-9-15(19-5-7-23-8-6-19)24-16-13(10-25-17(14)16)11-1-3-12(4-2-11)18(21)22/h1-4,9-10H,5-8H2,(H,21,22)
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n/an/a 295n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
PI3-kinase class I


(Homo sapiens (Human))
BDBM50427454
PNG
(CHEMBL2322239 | US10308662, Compound 6 | US9505780...)
Show SMILES O=c1cc(oc2c(csc12)-c1ccccc1)N1CCOCC1
Show InChI InChI=1S/C17H15NO3S/c19-14-10-15(18-6-8-20-9-7-18)21-16-13(11-22-17(14)16)12-4-2-1-3-5-12/h1-5,10-11H,6-9H2
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n/an/a 297n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 1


(Homo sapiens (Human))
BDBM50427485
PNG
(CHEMBL2326959 | US10308662, Compound 120 | US95057...)
Show SMILES O=C(Nc1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1)c1ccncc1
Show InChI InChI=1S/C23H19N3O4S/c27-19-13-20(26-9-11-29-12-10-26)30-21-18(14-31-22(19)21)15-1-3-17(4-2-15)25-23(28)16-5-7-24-8-6-16/h1-8,13-14H,9-12H2,(H,25,28)
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n/an/a 326n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 1


(Homo sapiens (Human))
BDBM259889
PNG
(US10308662, Compound 130 | US9505780, 130)
Show SMILES Cn1ncc2ccc(cc12)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C19H17N3O3S/c1-21-15-8-12(2-3-13(15)10-20-21)14-11-26-19-16(23)9-17(25-18(14)19)22-4-6-24-7-5-22/h2-3,8-11H,4-7H2,1H3
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n/an/a 349n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
PI3-kinase class I


(Homo sapiens (Human))
BDBM12915
PNG
(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)
Show SMILES O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1
Show InChI InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
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n/an/a 356n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM50427454
PNG
(CHEMBL2322239 | US10308662, Compound 6 | US9505780...)
Show SMILES O=c1cc(oc2c(csc12)-c1ccccc1)N1CCOCC1
Show InChI InChI=1S/C17H15NO3S/c19-14-10-15(18-6-8-20-9-7-18)21-16-13(11-22-17(14)16)12-4-2-1-3-5-12/h1-5,10-11H,6-9H2
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n/an/a 378n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 2


(Homo sapiens (Human))
BDBM50427485
PNG
(CHEMBL2326959 | US10308662, Compound 120 | US95057...)
Show SMILES O=C(Nc1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1)c1ccncc1
Show InChI InChI=1S/C23H19N3O4S/c27-19-13-20(26-9-11-29-12-10-26)30-21-18(14-31-22(19)21)15-1-3-17(4-2-15)25-23(28)16-5-7-24-8-6-16/h1-8,13-14H,9-12H2,(H,25,28)
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n/an/a 393n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
PI3-kinase class I


(Homo sapiens (Human))
BDBM50427456
PNG
(CHEMBL2326953 | US10308662, Compound 44 | US950578...)
Show SMILES COC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C19H17NO5S/c1-23-19(22)13-4-2-12(3-5-13)14-11-26-18-15(21)10-16(25-17(14)18)20-6-8-24-9-7-20/h2-5,10-11H,6-9H2,1H3
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n/an/a 400n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 2


(Homo sapiens (Human))
BDBM259890
PNG
(US10308662, Compound 131 | US9505780, 131)
Show SMILES Cc1n[nH]c2cc(ccc12)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C19H17N3O3S/c1-11-13-3-2-12(8-15(13)21-20-11)14-10-26-19-16(23)9-17(25-18(14)19)22-4-6-24-7-5-22/h2-3,8-10H,4-7H2,1H3,(H,20,21)
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n/an/a 446n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM259883
PNG
(US10308662, Compound 124 | US9505780, 124)
Show SMILES O=c1cc(oc2c(csc12)-c1ccc2OCCOc2c1)N1CCSCC1
Show InChI InChI=1S/C19H17NO4S2/c21-14-10-17(20-3-7-25-8-4-20)24-18-13(11-26-19(14)18)12-1-2-15-16(9-12)23-6-5-22-15/h1-2,9-11H,3-8H2
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n/an/a 480n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 1


(Homo sapiens (Human))
BDBM259883
PNG
(US10308662, Compound 124 | US9505780, 124)
Show SMILES O=c1cc(oc2c(csc12)-c1ccc2OCCOc2c1)N1CCSCC1
Show InChI InChI=1S/C19H17NO4S2/c21-14-10-17(20-3-7-25-8-4-20)24-18-13(11-26-19(14)18)12-1-2-15-16(9-12)23-6-5-22-15/h1-2,9-11H,3-8H2
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n/an/a 519n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50427456
PNG
(CHEMBL2326953 | US10308662, Compound 44 | US950578...)
Show SMILES COC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C19H17NO5S/c1-23-19(22)13-4-2-12(3-5-13)14-11-26-18-15(21)10-16(25-17(14)18)20-6-8-24-9-7-20/h2-5,10-11H,6-9H2,1H3
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n/an/a 547n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50427485
PNG
(CHEMBL2326959 | US10308662, Compound 120 | US95057...)
Show SMILES O=C(Nc1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1)c1ccncc1
Show InChI InChI=1S/C23H19N3O4S/c27-19-13-20(26-9-11-29-12-10-26)30-21-18(14-31-22(19)21)15-1-3-17(4-2-15)25-23(28)16-5-7-24-8-6-16/h1-8,13-14H,9-12H2,(H,25,28)
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n/an/a 556n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 1


(Homo sapiens (Human))
BDBM259892
PNG
(US10308662, Compound 133 | US9505780, 133)
Show SMILES CNC(=O)Nc1cccc(c1)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C19H19N3O4S/c1-20-19(24)21-13-4-2-3-12(9-13)14-11-27-18-15(23)10-16(26-17(14)18)22-5-7-25-8-6-22/h2-4,9-11H,5-8H2,1H3,(H2,20,21,24)
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n/an/a 558n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 2


(Homo sapiens (Human))
BDBM50427457
PNG
(CHEMBL2326952 | US10308662, Compound 25 | US950578...)
Show SMILES CCOC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C20H19NO5S/c1-2-25-20(23)14-5-3-13(4-6-14)15-12-27-19-16(22)11-17(26-18(15)19)21-7-9-24-10-8-21/h3-6,11-12H,2,7-10H2,1H3
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n/an/a 628n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 1


(Homo sapiens (Human))
BDBM259894
PNG
(US10308662, Compound 135 | US9505780, 135)
Show SMILES Cc1cccc(NC(=O)Nc2cccc(c2)-c2csc3c2oc(cc3=O)N2CCOCC2)c1
Show InChI InChI=1S/C25H23N3O4S/c1-16-4-2-6-18(12-16)26-25(30)27-19-7-3-5-17(13-19)20-15-33-24-21(29)14-22(32-23(20)24)28-8-10-31-11-9-28/h2-7,12-15H,8-11H2,1H3,(H2,26,27,30)
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n/an/a 646n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 1


(Homo sapiens (Human))
BDBM259893
PNG
(US10308662, Compound 134 | US9505780, 134)
Show SMILES CN(C)C(=O)Nc1cccc(c1)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C20H21N3O4S/c1-22(2)20(25)21-14-5-3-4-13(10-14)15-12-28-19-16(24)11-17(27-18(15)19)23-6-8-26-9-7-23/h3-5,10-12H,6-9H2,1-2H3,(H,21,25)
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n/an/a 662n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 2


(Homo sapiens (Human))
BDBM259889
PNG
(US10308662, Compound 130 | US9505780, 130)
Show SMILES Cn1ncc2ccc(cc12)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C19H17N3O3S/c1-21-15-8-12(2-3-13(15)10-20-21)14-11-26-19-16(23)9-17(25-18(14)19)22-4-6-24-7-5-22/h2-3,8-11H,4-7H2,1H3
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n/an/a 695n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
PI3-kinase class I


(Homo sapiens (Human))
BDBM50427457
PNG
(CHEMBL2326952 | US10308662, Compound 25 | US950578...)
Show SMILES CCOC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C20H19NO5S/c1-2-25-20(23)14-5-3-13(4-6-14)15-12-27-19-16(22)11-17(26-18(15)19)21-7-9-24-10-8-21/h3-6,11-12H,2,7-10H2,1H3
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n/an/a 714n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM12915
PNG
(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)
Show SMILES O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1
Show InChI InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
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n/an/a 736n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 1


(Homo sapiens (Human))
BDBM259896
PNG
(US10308662, Compound 137 | US9505780, 137)
Show SMILES Cc1ccc(C)c(NC(=O)Nc2cccc(c2)-c2csc3c2oc(cc3=O)N2CCOCC2)c1
Show InChI InChI=1S/C26H25N3O4S/c1-16-6-7-17(2)21(12-16)28-26(31)27-19-5-3-4-18(13-19)20-15-34-25-22(30)14-23(33-24(20)25)29-8-10-32-11-9-29/h3-7,12-15H,8-11H2,1-2H3,(H2,27,28,31)
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n/an/a 748n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50427454
PNG
(CHEMBL2322239 | US10308662, Compound 6 | US9505780...)
Show SMILES O=c1cc(oc2c(csc12)-c1ccccc1)N1CCOCC1
Show InChI InChI=1S/C17H15NO3S/c19-14-10-15(18-6-8-20-9-7-18)21-16-13(11-22-17(14)16)12-4-2-1-3-5-12/h1-5,10-11H,6-9H2
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n/an/a 784n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM259879
PNG
(US10308662, Compound 118 | US9505780, 118)
Show SMILES ONC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C18H16N2O5S/c21-14-9-15(20-5-7-24-8-6-20)25-16-13(10-26-17(14)16)11-1-3-12(4-2-11)18(22)19-23/h1-4,9-10,23H,5-8H2,(H,19,22)
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n/an/a 806n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 1


(Homo sapiens (Human))
BDBM50427456
PNG
(CHEMBL2326953 | US10308662, Compound 44 | US950578...)
Show SMILES COC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C19H17NO5S/c1-23-19(22)13-4-2-12(3-5-13)14-11-26-18-15(21)10-16(25-17(14)18)20-6-8-24-9-7-20/h2-5,10-11H,6-9H2,1H3
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n/an/a 811n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 1


(Homo sapiens (Human))
BDBM50427476
PNG
(CHEMBL2322247 | US10308662, Compound 11 | US950578...)
Show SMILES Nc1cccc(c1)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C17H16N2O3S/c18-12-3-1-2-11(8-12)13-10-23-17-14(20)9-15(22-16(13)17)19-4-6-21-7-5-19/h1-3,8-10H,4-7,18H2
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n/an/a 843n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
PI3-kinase class I


(Homo sapiens (Human))
BDBM259885
PNG
(US10308662, Compound 126 | US9505780, 126)
Show SMILES Brc1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C11H10BrNO3S/c12-7-6-17-11-8(14)5-9(16-10(7)11)13-1-3-15-4-2-13/h5-6H,1-4H2
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n/an/a 889n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
PI3-kinase class I


(Homo sapiens (Human))
BDBM259881
PNG
(US10308662, Compound 122 | US9505780, 122)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2cccc(c2)-c2csc3c2oc(cc3=O)N2CCOCC2)no1
Show InChI InChI=1S/C25H26N4O5S/c1-25(2,3)19-13-20(28-34-19)27-24(31)26-16-6-4-5-15(11-16)17-14-35-23-18(30)12-21(33-22(17)23)29-7-9-32-10-8-29/h4-6,11-14H,7-10H2,1-3H3,(H2,26,27,28,31)
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n/an/a 950n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50427453
PNG
(CHEMBL2322228 | US10308662, Compound 28 | US950578...)
Show SMILES O=c1cc(oc2c(csc12)-c1ccc2OCCOc2c1)N1CCOCC1
Show InChI InChI=1S/C19H17NO5S/c21-14-10-17(20-3-5-22-6-4-20)25-18-13(11-26-19(14)18)12-1-2-15-16(9-12)24-8-7-23-15/h1-2,9-11H,3-8H2
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n/an/a 960n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 1


(Homo sapiens (Human))
BDBM259884
PNG
(US10308662, Compound 125 | US9505780, 125)
Show SMILES CCOC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCSCC1
Show InChI InChI=1S/C20H19NO4S2/c1-2-24-20(23)14-5-3-13(4-6-14)15-12-27-19-16(22)11-17(25-18(15)19)21-7-9-26-10-8-21/h3-6,11-12H,2,7-10H2,1H3
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n/an/a 1.01E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM12915
PNG
(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)
Show SMILES O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1
Show InChI InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
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n/an/a 1.06E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
BRD4 bromodomain 1


(Homo sapiens (Human))
BDBM50427488
PNG
(CHEMBL2326956 | US10308662, Compound 100 | US95057...)
Show SMILES OC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C18H15NO5S/c20-14-9-15(19-5-7-23-8-6-19)24-16-13(10-25-17(14)16)11-1-3-12(4-2-11)18(21)22/h1-4,9-10H,5-8H2,(H,21,22)
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n/an/a 1.09E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 2


(Homo sapiens (Human))
BDBM259892
PNG
(US10308662, Compound 133 | US9505780, 133)
Show SMILES CNC(=O)Nc1cccc(c1)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C19H19N3O4S/c1-20-19(24)21-13-4-2-3-12(9-13)14-11-27-18-15(23)10-16(26-17(14)18)22-5-7-25-8-6-22/h2-4,9-11H,5-8H2,1H3,(H2,20,21,24)
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n/an/a 1.12E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50427457
PNG
(CHEMBL2326952 | US10308662, Compound 25 | US950578...)
Show SMILES CCOC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C20H19NO5S/c1-2-25-20(23)14-5-3-13(4-6-14)15-12-27-19-16(22)11-17(26-18(15)19)21-7-9-24-10-8-21/h3-6,11-12H,2,7-10H2,1H3
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n/an/a 1.17E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 2


(Homo sapiens (Human))
BDBM259896
PNG
(US10308662, Compound 137 | US9505780, 137)
Show SMILES Cc1ccc(C)c(NC(=O)Nc2cccc(c2)-c2csc3c2oc(cc3=O)N2CCOCC2)c1
Show InChI InChI=1S/C26H25N3O4S/c1-16-6-7-17(2)21(12-16)28-26(31)27-19-5-3-4-18(13-19)20-15-34-25-22(30)14-23(33-24(20)25)29-8-10-32-11-9-29/h3-7,12-15H,8-11H2,1-2H3,(H2,27,28,31)
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n/an/a 1.26E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 2


(Homo sapiens (Human))
BDBM259895
PNG
(US10308662, Compound 136 | US9505780, 136)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2csc3c2oc(cc3=O)N2CCOCC2)c1
Show InChI InChI=1S/C25H20F3N3O4S/c26-25(27,28)16-4-2-6-18(12-16)30-24(33)29-17-5-1-3-15(11-17)19-14-36-23-20(32)13-21(35-22(19)23)31-7-9-34-10-8-31/h1-6,11-14H,7-10H2,(H2,29,30,33)
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n/an/a 1.26E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 2


(Homo sapiens (Human))
BDBM259894
PNG
(US10308662, Compound 135 | US9505780, 135)
Show SMILES Cc1cccc(NC(=O)Nc2cccc(c2)-c2csc3c2oc(cc3=O)N2CCOCC2)c1
Show InChI InChI=1S/C25H23N3O4S/c1-16-4-2-6-18(12-16)26-25(30)27-19-7-3-5-17(13-19)20-15-33-24-21(29)14-22(32-23(20)24)28-8-10-31-11-9-28/h2-7,12-15H,8-11H2,1H3,(H2,26,27,30)
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n/an/a 1.27E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM259881
PNG
(US10308662, Compound 122 | US9505780, 122)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2cccc(c2)-c2csc3c2oc(cc3=O)N2CCOCC2)no1
Show InChI InChI=1S/C25H26N4O5S/c1-25(2,3)19-13-20(28-34-19)27-24(31)26-16-6-4-5-15(11-16)17-14-35-23-18(30)12-21(33-22(17)23)29-7-9-32-10-8-29/h4-6,11-14H,7-10H2,1-3H3,(H2,26,27,28,31)
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n/an/a 1.35E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 2


(Homo sapiens (Human))
BDBM50427456
PNG
(CHEMBL2326953 | US10308662, Compound 44 | US950578...)
Show SMILES COC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C19H17NO5S/c1-23-19(22)13-4-2-12(3-5-13)14-11-26-18-15(21)10-16(25-17(14)18)20-6-8-24-9-7-20/h2-5,10-11H,6-9H2,1H3
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n/an/a 1.47E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM259885
PNG
(US10308662, Compound 126 | US9505780, 126)
Show SMILES Brc1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C11H10BrNO3S/c12-7-6-17-11-8(14)5-9(16-10(7)11)13-1-3-15-4-2-13/h5-6H,1-4H2
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n/an/a 1.48E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 2


(Homo sapiens (Human))
BDBM50427453
PNG
(CHEMBL2322228 | US10308662, Compound 28 | US950578...)
Show SMILES O=c1cc(oc2c(csc12)-c1ccc2OCCOc2c1)N1CCOCC1
Show InChI InChI=1S/C19H17NO5S/c21-14-10-17(20-3-5-22-6-4-20)25-18-13(11-26-19(14)18)12-1-2-15-16(9-12)24-8-7-23-15/h1-2,9-11H,3-8H2
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n/an/a 1.55E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50427454
PNG
(CHEMBL2322239 | US10308662, Compound 6 | US9505780...)
Show SMILES O=c1cc(oc2c(csc12)-c1ccccc1)N1CCOCC1
Show InChI InChI=1S/C17H15NO3S/c19-14-10-15(18-6-8-20-9-7-18)21-16-13(11-22-17(14)16)12-4-2-1-3-5-12/h1-5,10-11H,6-9H2
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n/an/a 1.57E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
PI3-kinase class I


(Homo sapiens (Human))
BDBM259883
PNG
(US10308662, Compound 124 | US9505780, 124)
Show SMILES O=c1cc(oc2c(csc12)-c1ccc2OCCOc2c1)N1CCSCC1
Show InChI InChI=1S/C19H17NO4S2/c21-14-10-17(20-3-7-25-8-4-20)24-18-13(11-26-19(14)18)12-1-2-15-16(9-12)23-6-5-22-15/h1-2,9-11H,3-8H2
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n/an/a 1.58E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
PI3-kinase class I


(Homo sapiens (Human))
BDBM259886
PNG
(US10308662, Compound 127 | US9505780, 127)
Show SMILES Brc1csc2c1oc(cc2=O)N1CCSCC1
Show InChI InChI=1S/C11H10BrNO2S2/c12-7-6-17-11-8(14)5-9(15-10(7)11)13-1-3-16-4-2-13/h5-6H,1-4H2
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n/an/a 1.72E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 2


(Homo sapiens (Human))
BDBM50427476
PNG
(CHEMBL2322247 | US10308662, Compound 11 | US950578...)
Show SMILES Nc1cccc(c1)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C17H16N2O3S/c18-12-3-1-2-11(8-12)13-10-23-17-14(20)9-15(22-16(13)17)19-4-6-21-7-5-19/h1-3,8-10H,4-7,18H2
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n/an/a 1.74E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM50427457
PNG
(CHEMBL2326952 | US10308662, Compound 25 | US950578...)
Show SMILES CCOC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C20H19NO5S/c1-2-25-20(23)14-5-3-13(4-6-14)15-12-27-19-16(22)11-17(26-18(15)19)21-7-9-24-10-8-21/h3-6,11-12H,2,7-10H2,1H3
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n/an/a 1.75E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 2


(Homo sapiens (Human))
BDBM259893
PNG
(US10308662, Compound 134 | US9505780, 134)
Show SMILES CN(C)C(=O)Nc1cccc(c1)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C20H21N3O4S/c1-22(2)20(25)21-14-5-3-4-13(10-14)15-12-28-19-16(24)11-17(27-18(15)19)23-6-8-26-9-7-23/h3-5,10-12H,6-9H2,1-2H3,(H,21,25)
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n/an/a 1.85E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 2


(Homo sapiens (Human))
BDBM259884
PNG
(US10308662, Compound 125 | US9505780, 125)
Show SMILES CCOC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCSCC1
Show InChI InChI=1S/C20H19NO4S2/c1-2-24-20(23)14-5-3-13(4-6-14)15-12-27-19-16(22)11-17(25-18(15)19)21-7-9-26-10-8-21/h3-6,11-12H,2,7-10H2,1H3
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n/an/a 1.87E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 1


(Homo sapiens (Human))
BDBM50427454
PNG
(CHEMBL2322239 | US10308662, Compound 6 | US9505780...)
Show SMILES O=c1cc(oc2c(csc12)-c1ccccc1)N1CCOCC1
Show InChI InChI=1S/C17H15NO3S/c19-14-10-15(18-6-8-20-9-7-18)21-16-13(11-22-17(14)16)12-4-2-1-3-5-12/h1-5,10-11H,6-9H2
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n/an/a 2.17E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM259885
PNG
(US10308662, Compound 126 | US9505780, 126)
Show SMILES Brc1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C11H10BrNO3S/c12-7-6-17-11-8(14)5-9(16-10(7)11)13-1-3-15-4-2-13/h5-6H,1-4H2
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n/an/a 2.20E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 1


(Homo sapiens (Human))
BDBM259888
PNG
(US10308662, Compound 129 | US9505780, 129)
Show SMILES O=c1cc(oc2c(csc12)-c1ccn[nH]1)N1CCOCC1
Show InChI InChI=1S/C14H13N3O3S/c18-11-7-12(17-3-5-19-6-4-17)20-13-9(8-21-14(11)13)10-1-2-15-16-10/h1-2,7-8H,3-6H2,(H,15,16)
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n/an/a 2.23E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 2


(Homo sapiens (Human))
BDBM259880
PNG
(US10308662, Compound 121 | US9505780, 121)
Show SMILES Fc1ccc(C(=O)Nc2ccc(cc2)-c2csc3c2oc(cc3=O)N2CCOCC2)c(Nc2ccc(I)cc2F)c1F
Show InChI InChI=1S/C30H21F3IN3O4S/c31-21-7-6-19(27(26(21)33)36-23-8-3-17(34)13-22(23)32)30(39)35-18-4-1-16(2-5-18)20-15-42-29-24(38)14-25(41-28(20)29)37-9-11-40-12-10-37/h1-8,13-15,36H,9-12H2,(H,35,39)
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n/an/a 2.31E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM259884
PNG
(US10308662, Compound 125 | US9505780, 125)
Show SMILES CCOC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCSCC1
Show InChI InChI=1S/C20H19NO4S2/c1-2-24-20(23)14-5-3-13(4-6-14)15-12-27-19-16(22)11-17(25-18(15)19)21-7-9-26-10-8-21/h3-6,11-12H,2,7-10H2,1H3
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n/an/a 2.49E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 1


(Homo sapiens (Human))
BDBM259881
PNG
(US10308662, Compound 122 | US9505780, 122)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2cccc(c2)-c2csc3c2oc(cc3=O)N2CCOCC2)no1
Show InChI InChI=1S/C25H26N4O5S/c1-25(2,3)19-13-20(28-34-19)27-24(31)26-16-6-4-5-15(11-16)17-14-35-23-18(30)12-21(33-22(17)23)29-7-9-32-10-8-29/h4-6,11-14H,7-10H2,1-3H3,(H2,26,27,28,31)
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n/an/a 2.57E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 2


(Homo sapiens (Human))
BDBM50427488
PNG
(CHEMBL2326956 | US10308662, Compound 100 | US95057...)
Show SMILES OC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C18H15NO5S/c20-14-9-15(19-5-7-23-8-6-19)24-16-13(10-25-17(14)16)11-1-3-12(4-2-11)18(21)22/h1-4,9-10H,5-8H2,(H,21,22)
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n/an/a 2.76E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 2


(Homo sapiens (Human))
BDBM259883
PNG
(US10308662, Compound 124 | US9505780, 124)
Show SMILES O=c1cc(oc2c(csc12)-c1ccc2OCCOc2c1)N1CCSCC1
Show InChI InChI=1S/C19H17NO4S2/c21-14-10-17(20-3-7-25-8-4-20)24-18-13(11-26-19(14)18)12-1-2-15-16(9-12)23-6-5-22-15/h1-2,9-11H,3-8H2
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n/an/a 2.80E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM12915
PNG
(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)
Show SMILES O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1
Show InChI InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
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n/an/a 3.22E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM259886
PNG
(US10308662, Compound 127 | US9505780, 127)
Show SMILES Brc1csc2c1oc(cc2=O)N1CCSCC1
Show InChI InChI=1S/C11H10BrNO2S2/c12-7-6-17-11-8(14)5-9(15-10(7)11)13-1-3-16-4-2-13/h5-6H,1-4H2
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n/an/a 3.30E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 2


(Homo sapiens (Human))
BDBM50427454
PNG
(CHEMBL2322239 | US10308662, Compound 6 | US9505780...)
Show SMILES O=c1cc(oc2c(csc12)-c1ccccc1)N1CCOCC1
Show InChI InChI=1S/C17H15NO3S/c19-14-10-15(18-6-8-20-9-7-18)21-16-13(11-22-17(14)16)12-4-2-1-3-5-12/h1-5,10-11H,6-9H2
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n/an/a 3.45E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM50427456
PNG
(CHEMBL2326953 | US10308662, Compound 44 | US950578...)
Show SMILES COC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C19H17NO5S/c1-23-19(22)13-4-2-12(3-5-13)14-11-26-18-15(21)10-16(25-17(14)18)20-6-8-24-9-7-20/h2-5,10-11H,6-9H2,1H3
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n/an/a 3.60E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 1


(Homo sapiens (Human))
BDBM259887
PNG
(US10308662, Compound 128 | US9505780, 128)
Show SMILES O=c1cc(oc2c(csc12)C#Cc1ccccc1)N1CCOCC1
Show InChI InChI=1S/C19H15NO3S/c21-16-12-17(20-8-10-22-11-9-20)23-18-15(13-24-19(16)18)7-6-14-4-2-1-3-5-14/h1-5,12-13H,8-11H2
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n/an/a 4.00E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM259883
PNG
(US10308662, Compound 124 | US9505780, 124)
Show SMILES O=c1cc(oc2c(csc12)-c1ccc2OCCOc2c1)N1CCSCC1
Show InChI InChI=1S/C19H17NO4S2/c21-14-10-17(20-3-7-25-8-4-20)24-18-13(11-26-19(14)18)12-1-2-15-16(9-12)23-6-5-22-15/h1-2,9-11H,3-8H2
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n/an/a 4.63E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 2


(Homo sapiens (Human))
BDBM259881
PNG
(US10308662, Compound 122 | US9505780, 122)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2cccc(c2)-c2csc3c2oc(cc3=O)N2CCOCC2)no1
Show InChI InChI=1S/C25H26N4O5S/c1-25(2,3)19-13-20(28-34-19)27-24(31)26-16-6-4-5-15(11-16)17-14-35-23-18(30)12-21(33-22(17)23)29-7-9-32-10-8-29/h4-6,11-14H,7-10H2,1-3H3,(H2,26,27,28,31)
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n/an/a 4.88E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 1


(Homo sapiens (Human))
BDBM12915
PNG
(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)
Show SMILES O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1
Show InChI InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
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n/an/a 5.33E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 1


(Homo sapiens (Human))
BDBM259891
PNG
(US10308662, Compound 132 | US9505780, 132)
Show SMILES Cc1nnc(o1)-c1cccc(c1)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C20H17N3O4S/c1-12-21-22-20(26-12)14-4-2-3-13(9-14)15-11-28-19-16(24)10-17(27-18(15)19)23-5-7-25-8-6-23/h2-4,9-11H,5-8H2,1H3
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n/an/a 5.48E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 1


(Homo sapiens (Human))
BDBM259895
PNG
(US10308662, Compound 136 | US9505780, 136)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2csc3c2oc(cc3=O)N2CCOCC2)c1
Show InChI InChI=1S/C25H20F3N3O4S/c26-25(27,28)16-4-2-6-18(12-16)30-24(33)29-17-5-1-3-15(11-17)19-14-36-23-20(32)13-21(35-22(19)23)31-7-9-34-10-8-31/h1-6,11-14H,7-10H2,(H2,29,30,33)
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n/an/a 6.15E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50427476
PNG
(CHEMBL2322247 | US10308662, Compound 11 | US950578...)
Show SMILES Nc1cccc(c1)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C17H16N2O3S/c18-12-3-1-2-11(8-12)13-10-23-17-14(20)9-15(22-16(13)17)19-4-6-21-7-5-19/h1-3,8-10H,4-7,18H2
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n/an/a 6.30E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
PI3-kinase class I


(Homo sapiens (Human))
BDBM50427490
PNG
(CHEMBL2322246 | US10308662, Compound 10 | US950578...)
Show SMILES O=c1cc(oc2ccsc12)N1CCOCC1
Show InChI InChI=1S/C11H11NO3S/c13-8-7-10(12-2-4-14-5-3-12)15-9-1-6-16-11(8)9/h1,6-7H,2-5H2
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n/an/a 7.16E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
PI3-kinase class I


(Homo sapiens (Human))
BDBM259882
PNG
(US10308662, Compound 123 | US9505780, 123)
Show SMILES FC(F)(F)c1cc(NC(=O)Nc2cccc(c2)-c2csc3c2oc(cc3=O)N2CCOCC2)ccc1Cl
Show InChI InChI=1S/C25H19ClF3N3O4S/c26-19-5-4-16(11-18(19)25(27,28)29)31-24(34)30-15-3-1-2-14(10-15)17-13-37-23-20(33)12-21(36-22(17)23)32-6-8-35-9-7-32/h1-5,10-13H,6-9H2,(H2,30,31,34)
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n/an/a 7.67E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM259881
PNG
(US10308662, Compound 122 | US9505780, 122)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2cccc(c2)-c2csc3c2oc(cc3=O)N2CCOCC2)no1
Show InChI InChI=1S/C25H26N4O5S/c1-25(2,3)19-13-20(28-34-19)27-24(31)26-16-6-4-5-15(11-16)17-14-35-23-18(30)12-21(33-22(17)23)29-7-9-32-10-8-29/h4-6,11-14H,7-10H2,1-3H3,(H2,26,27,28,31)
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n/an/a 8.65E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM50427490
PNG
(CHEMBL2322246 | US10308662, Compound 10 | US950578...)
Show SMILES O=c1cc(oc2ccsc12)N1CCOCC1
Show InChI InChI=1S/C11H11NO3S/c13-8-7-10(12-2-4-14-5-3-12)15-9-1-6-16-11(8)9/h1,6-7H,2-5H2
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n/an/a 9.25E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 2


(Homo sapiens (Human))
BDBM259888
PNG
(US10308662, Compound 129 | US9505780, 129)
Show SMILES O=c1cc(oc2c(csc12)-c1ccn[nH]1)N1CCOCC1
Show InChI InChI=1S/C14H13N3O3S/c18-11-7-12(17-3-5-19-6-4-17)20-13-9(8-21-14(11)13)10-1-2-15-16-10/h1-2,7-8H,3-6H2,(H,15,16)
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n/an/a 9.41E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM259882
PNG
(US10308662, Compound 123 | US9505780, 123)
Show SMILES FC(F)(F)c1cc(NC(=O)Nc2cccc(c2)-c2csc3c2oc(cc3=O)N2CCOCC2)ccc1Cl
Show InChI InChI=1S/C25H19ClF3N3O4S/c26-19-5-4-16(11-18(19)25(27,28)29)31-24(34)30-15-3-1-2-14(10-15)17-13-37-23-20(33)12-21(36-22(17)23)32-6-8-35-9-7-32/h1-5,10-13H,6-9H2,(H2,30,31,34)
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n/an/a 9.75E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM259886
PNG
(US10308662, Compound 127 | US9505780, 127)
Show SMILES Brc1csc2c1oc(cc2=O)N1CCSCC1
Show InChI InChI=1S/C11H10BrNO2S2/c12-7-6-17-11-8(14)5-9(15-10(7)11)13-1-3-16-4-2-13/h5-6H,1-4H2
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n/an/a 9.77E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50427476
PNG
(CHEMBL2322247 | US10308662, Compound 11 | US950578...)
Show SMILES Nc1cccc(c1)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C17H16N2O3S/c18-12-3-1-2-11(8-12)13-10-23-17-14(20)9-15(22-16(13)17)19-4-6-21-7-5-19/h1-3,8-10H,4-7,18H2
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n/an/a 9.81E+3n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
PI3-kinase class I


(Homo sapiens (Human))
BDBM259880
PNG
(US10308662, Compound 121 | US9505780, 121)
Show SMILES Fc1ccc(C(=O)Nc2ccc(cc2)-c2csc3c2oc(cc3=O)N2CCOCC2)c(Nc2ccc(I)cc2F)c1F
Show InChI InChI=1S/C30H21F3IN3O4S/c31-21-7-6-19(27(26(21)33)36-23-8-3-17(34)13-22(23)32)30(39)35-18-4-1-16(2-5-18)20-15-42-29-24(38)14-25(41-28(20)29)37-9-11-40-12-10-37/h1-8,13-15,36H,9-12H2,(H,35,39)
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n/an/a<1.00E+4n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 2


(Homo sapiens (Human))
BDBM259887
PNG
(US10308662, Compound 128 | US9505780, 128)
Show SMILES O=c1cc(oc2c(csc12)C#Cc1ccccc1)N1CCOCC1
Show InChI InChI=1S/C19H15NO3S/c21-16-12-17(20-8-10-22-11-9-20)23-18-15(13-24-19(16)18)7-6-14-4-2-1-3-5-14/h1-5,12-13H,8-11H2
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n/an/a 1.07E+4n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 2


(Homo sapiens (Human))
BDBM259891
PNG
(US10308662, Compound 132 | US9505780, 132)
Show SMILES Cc1nnc(o1)-c1cccc(c1)-c1csc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C20H17N3O4S/c1-12-21-22-20(26-12)14-4-2-3-13(9-14)15-11-28-19-16(24)10-17(27-18(15)19)23-5-7-25-8-6-23/h2-4,9-11H,5-8H2,1H3
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n/an/a 1.16E+4n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 2


(Homo sapiens (Human))
BDBM12915
PNG
(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)
Show SMILES O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1
Show InChI InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
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n/an/a 1.31E+4n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM259882
PNG
(US10308662, Compound 123 | US9505780, 123)
Show SMILES FC(F)(F)c1cc(NC(=O)Nc2cccc(c2)-c2csc3c2oc(cc3=O)N2CCOCC2)ccc1Cl
Show InChI InChI=1S/C25H19ClF3N3O4S/c26-19-5-4-16(11-18(19)25(27,28)29)31-24(34)30-15-3-1-2-14(10-15)17-13-37-23-20(33)12-21(36-22(17)23)32-6-8-35-9-7-32/h1-5,10-13H,6-9H2,(H2,30,31,34)
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n/an/a>1.67E+4n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
PI3-kinase class I


(Homo sapiens (Human))
BDBM259884
PNG
(US10308662, Compound 125 | US9505780, 125)
Show SMILES CCOC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCSCC1
Show InChI InChI=1S/C20H19NO4S2/c1-2-24-20(23)14-5-3-13(4-6-14)15-12-27-19-16(22)11-17(25-18(15)19)21-7-9-26-10-8-21/h3-6,11-12H,2,7-10H2,1H3
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n/an/a 2.91E+4n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 1


(Homo sapiens (Human))
BDBM259886
PNG
(US10308662, Compound 127 | US9505780, 127)
Show SMILES Brc1csc2c1oc(cc2=O)N1CCSCC1
Show InChI InChI=1S/C11H10BrNO2S2/c12-7-6-17-11-8(14)5-9(15-10(7)11)13-1-3-16-4-2-13/h5-6H,1-4H2
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n/an/a 3.27E+4n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 2


(Homo sapiens (Human))
BDBM259886
PNG
(US10308662, Compound 127 | US9505780, 127)
Show SMILES Brc1csc2c1oc(cc2=O)N1CCSCC1
Show InChI InChI=1S/C11H10BrNO2S2/c12-7-6-17-11-8(14)5-9(15-10(7)11)13-1-3-16-4-2-13/h5-6H,1-4H2
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n/an/a 3.42E+4n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM259884
PNG
(US10308662, Compound 125 | US9505780, 125)
Show SMILES CCOC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCSCC1
Show InChI InChI=1S/C20H19NO4S2/c1-2-24-20(23)14-5-3-13(4-6-14)15-12-27-19-16(22)11-17(25-18(15)19)21-7-9-26-10-8-21/h3-6,11-12H,2,7-10H2,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 1


(Homo sapiens (Human))
BDBM259882
PNG
(US10308662, Compound 123 | US9505780, 123)
Show SMILES FC(F)(F)c1cc(NC(=O)Nc2cccc(c2)-c2csc3c2oc(cc3=O)N2CCOCC2)ccc1Cl
Show InChI InChI=1S/C25H19ClF3N3O4S/c26-19-5-4-16(11-18(19)25(27,28)29)31-24(34)30-15-3-1-2-14(10-15)17-13-37-23-20(33)12-21(36-22(17)23)32-6-8-35-9-7-32/h1-5,10-13H,6-9H2,(H2,30,31,34)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
BRD4 bromodomain 2


(Homo sapiens (Human))
BDBM259882
PNG
(US10308662, Compound 123 | US9505780, 123)
Show SMILES FC(F)(F)c1cc(NC(=O)Nc2cccc(c2)-c2csc3c2oc(cc3=O)N2CCOCC2)ccc1Cl
Show InChI InChI=1S/C25H19ClF3N3O4S/c26-19-5-4-16(11-18(19)25(27,28)29)31-24(34)30-15-3-1-2-14(10-15)17-13-37-23-20(33)12-21(36-22(17)23)32-6-8-35-9-7-32/h1-5,10-13H,6-9H2,(H2,30,31,34)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50427490
PNG
(CHEMBL2322246 | US10308662, Compound 10 | US950578...)
Show SMILES O=c1cc(oc2ccsc12)N1CCOCC1
Show InChI InChI=1S/C11H11NO3S/c13-8-7-10(12-2-4-14-5-3-12)15-9-1-6-16-11(8)9/h1,6-7H,2-5H2
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n/an/a>5.00E+4n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50365262
PNG
( (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10124009, C...)
Show SMILES Cc1nnc2[C@H](CC(=O)OC(C)(C)C)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1
Show InChI InChI=1/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/s2
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n/an/a>5.00E+4n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50365262
PNG
( (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10124009, C...)
Show SMILES Cc1nnc2[C@H](CC(=O)OC(C)(C)C)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1
Show InChI InChI=1/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/s2
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n/an/a>5.00E+4n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
PI3-kinase class I


(Homo sapiens (Human))
BDBM50365262
PNG
( (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10124009, C...)
Show SMILES Cc1nnc2[C@H](CC(=O)OC(C)(C)C)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1
Show InChI InChI=1/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/s2
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n/an/a>5.00E+4n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50427490
PNG
(CHEMBL2322246 | US10308662, Compound 10 | US950578...)
Show SMILES O=c1cc(oc2ccsc12)N1CCOCC1
Show InChI InChI=1S/C11H11NO3S/c13-8-7-10(12-2-4-14-5-3-12)15-9-1-6-16-11(8)9/h1,6-7H,2-5H2
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n/an/a>5.00E+4n/an/an/an/an/an/a



Signal Rx Pharmaceuticals., Inc.

US Patent


Assay Description
Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...


US Patent US10308662 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%