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Patent code US10308663

Compile Data Set for Download or QSAR
Found 3 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein-tyrosine phosphatase 4A3


(Homo sapiens (Human))
BDBM396097
PNG
(US10308663, JMS-631-053)
Show SMILES N=C1c2sc(cc2C(=O)NC1=O)-c1ccccc1
Show InChI InChI=1S/C13H8N2O2S/c14-10-11-8(12(16)15-13(10)17)6-9(18-11)7-4-2-1-3-5-7/h1-6,14H,(H,15,16,17)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 18n/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
The in vitro biochemical evaluation of all compounds was carried out using recombinant human PTP4A3, overexpressed as a His6-tag fusion protein in E....


US Patent US10308663 (2019)


BindingDB Entry DOI: 10.7270/Q20867N2
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens (Human))
BDBM50059084
PNG
(CHEMBL3393171 | US10308663, Thienopyridone (5))
Show SMILES Nc1c[nH]c(=O)c2cc(sc12)-c1ccccc1
Show InChI InChI=1S/C13H10N2OS/c14-10-7-15-13(16)9-6-11(17-12(9)10)8-4-2-1-3-5-8/h1-7H,14H2,(H,15,16)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 132n/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
The in vitro biochemical evaluation of all compounds was carried out using recombinant human PTP4A3, overexpressed as a His6-tag fusion protein in E....


US Patent US10308663 (2019)


BindingDB Entry DOI: 10.7270/Q20867N2
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens (Human))
BDBM396098
PNG
(US10308663, JMS-557-038)
Show SMILES O=c1[nH]c2sc(cc2c(=O)[nH]1)-c1ccccc1
Show InChI InChI=1S/C12H8N2O2S/c15-10-8-6-9(7-4-2-1-3-5-7)17-11(8)14-12(16)13-10/h1-6H,(H2,13,14,15,16)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>2.50E+5n/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
The in vitro biochemical evaluation of all compounds was carried out using recombinant human PTP4A3, overexpressed as a His6-tag fusion protein in E....


US Patent US10308663 (2019)


BindingDB Entry DOI: 10.7270/Q20867N2
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%