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Patent code US10308663

Compile Data Set for Download or QSAR
Found 3 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein-tyrosine phosphatase 4A3


(Homo sapiens (Human))
BDBM396097
PNG
(US10308663, JMS-631-053)
Show SMILES N=C1c2sc(cc2C(=O)NC1=O)-c1ccccc1
Show InChI InChI=1S/C13H8N2O2S/c14-10-11-8(12(16)15-13(10)17)6-9(18-11)7-4-2-1-3-5-7/h1-6,14H,(H,15,16,17)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 18n/an/an/an/an/an/a



University of Virginia Patent Foundation; University of Pittsburgh —Of the Commonwealth System of Higher Education

US Patent


Assay Description
The in vitro biochemical evaluation of all compounds was carried out using recombinant human PTP4A3, overexpressed as a His6-tag fusion protein in E....


US Patent US10308663 (2019)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens (Human))
BDBM50059084
PNG
(CHEMBL3393171 | US10308663, Thienopyridone (5))
Show SMILES Nc1c[nH]c(=O)c2cc(sc12)-c1ccccc1
Show InChI InChI=1S/C13H10N2OS/c14-10-7-15-13(16)9-6-11(17-12(9)10)8-4-2-1-3-5-8/h1-7H,14H2,(H,15,16)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 132n/an/an/an/an/an/a



University of Virginia Patent Foundation; University of Pittsburgh —Of the Commonwealth System of Higher Education

US Patent


Assay Description
The in vitro biochemical evaluation of all compounds was carried out using recombinant human PTP4A3, overexpressed as a His6-tag fusion protein in E....


US Patent US10308663 (2019)

More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 4A3


(Homo sapiens (Human))
BDBM396098
PNG
(US10308663, JMS-557-038)
Show SMILES O=c1[nH]c2sc(cc2c(=O)[nH]1)-c1ccccc1
Show InChI InChI=1S/C12H8N2O2S/c15-10-8-6-9(7-4-2-1-3-5-7)17-11(8)14-12(16)13-10/h1-6H,(H2,13,14,15,16)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>2.50E+5n/an/an/an/an/an/a



University of Virginia Patent Foundation; University of Pittsburgh —Of the Commonwealth System of Higher Education

US Patent


Assay Description
The in vitro biochemical evaluation of all compounds was carried out using recombinant human PTP4A3, overexpressed as a His6-tag fusion protein in E....


US Patent US10308663 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%