BindingDB logo
myBDB logout

Patent code US10308667

Compile Data Set for Download or QSAR
Found 168 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396227
PNG
(6-[5-Bromo-6-(2-oxa-6-aza-spiro[3.3]hept-6-yl)-pyr...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(n1)N1CC2(COC2)C1
Show InChI InChI=1S/C17H17BrN6O2/c1-9-11(13(19)14-15(20-9)23-26-22-14)4-10-2-3-12(18)16(21-10)24-5-17(6-24)7-25-8-17/h2-3H,4-8,19H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0200n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396236
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(NC2CC2)n1
Show InChI InChI=1S/C16H15N7O/c1-8-12(13(18)14-16(19-8)23-24-22-14)6-11-3-2-9(7-17)15(21-11)20-10-4-5-10/h2-3,10H,4-6,18H2,1H3,(H,20,21)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0200n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396194
PNG
(6-(5-Bromo-6-methoxy-pyridin-2-ylmethyl)-5-methyl-...)
Show SMILES COc1nc(Cc2c(C)nc3nonc3c2N)ccc1Br
Show InChI InChI=1S/C13H12BrN5O2/c1-6-8(10(15)11-12(16-6)19-21-18-11)5-7-3-4-9(14)13(17-7)20-2/h3-4H,5,15H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0220n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396205
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(OCCCF)n1
Show InChI InChI=1S/C16H15FN6O2/c1-9-12(13(19)14-15(20-9)23-25-22-14)7-11-4-3-10(8-18)16(21-11)24-6-2-5-17/h3-4H,2,5-7,19H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0260n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396220
PNG
(6-(5-Bromo-6-morpholin-4-yl-pyridin-2-ylmethyl)-5-...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(n1)N1CCOCC1
Show InChI InChI=1S/C16H17BrN6O2/c1-9-11(13(18)14-15(19-9)22-25-21-14)8-10-2-3-12(17)16(20-10)23-4-6-24-7-5-23/h2-3H,4-8,18H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0260n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396246
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(NCCCF)n1
Show InChI InChI=1S/C16H16FN7O/c1-9-12(13(19)14-16(21-9)24-25-23-14)7-11-4-3-10(8-18)15(22-11)20-6-2-5-17/h3-4H,2,5-7,19H2,1H3,(H,20,22)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0270n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396239
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(n1)N1CC(F)(F)C1
Show InChI InChI=1S/C16H13F2N7O/c1-8-11(12(20)13-14(21-8)24-26-23-13)4-10-3-2-9(5-19)15(22-10)25-6-16(17,18)7-25/h2-3H,4,6-7,20H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0270n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396118
PNG
(6-(5,6-Dibromo-pyridin-2-ylmethyl)-5-methyl-[1,2,5...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(Br)n1
Show InChI InChI=1S/C12H9Br2N5O/c1-5-7(4-6-2-3-8(13)11(14)17-6)9(15)10-12(16-5)19-20-18-10/h2-3H,4,15H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0300n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396233
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(n1)N1CCOCC1
Show InChI InChI=1S/C17H17N7O2/c1-10-13(14(19)15-16(20-10)23-26-22-15)8-12-3-2-11(9-18)17(21-12)24-4-6-25-7-5-24/h2-3H,4-8,19H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0330n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396219
PNG
(1-[6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyr...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(n1)N1CC(C)(O)C1
Show InChI InChI=1S/C16H17BrN6O2/c1-8-10(12(18)13-14(19-8)22-25-21-13)5-9-3-4-11(17)15(20-9)23-6-16(2,24)7-23/h3-4,24H,5-7,18H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0330n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396197
PNG
(6-[5-Bromo-6-(2-fluoro-ethoxy)-pyridin-2-ylmethyl]...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(OCCF)n1
Show InChI InChI=1S/C14H13BrFN5O2/c1-7-9(11(17)12-13(18-7)21-23-20-12)6-8-2-3-10(15)14(19-8)22-5-4-16/h2-3H,4-6,17H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0340n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396112
PNG
(6-(6-Bromo-5-difluoromethoxy-pyridin-2-ylmethyl)-5...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(OC(F)F)c(Br)n1
Show InChI InChI=1S/C13H10BrF2N5O2/c1-5-7(9(17)10-12(18-5)21-23-20-10)4-6-2-3-8(11(14)19-6)22-13(15)16/h2-3,13H,4,17H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0380n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396222
PNG
(6-(5-Bromo-6-cyclopropylamino-pyridin-2-ylmethyl)-...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(NC2CC2)n1
Show InChI InChI=1S/C15H15BrN6O/c1-7-10(12(17)13-15(18-7)22-23-21-13)6-9-4-5-11(16)14(20-9)19-8-2-3-8/h4-5,8H,2-3,6,17H2,1H3,(H,19,20)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0380n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396218
PNG
(6-{5-Bromo-6-[(3-methyl-oxetan-3-ylmethyl)-amino]-...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(NCC2(C)COC2)n1
Show InChI InChI=1S/C17H19BrN6O2/c1-9-11(13(19)14-16(21-9)24-26-23-14)5-10-3-4-12(18)15(22-10)20-6-17(2)7-25-8-17/h3-4H,5-8,19H2,1-2H3,(H,20,22)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0450n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396240
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(n1)N1CCC(F)(F)C1
Show InChI InChI=1S/C17H15F2N7O/c1-9-12(13(21)14-15(22-9)25-27-24-14)6-11-3-2-10(7-20)16(23-11)26-5-4-17(18,19)8-26/h2-3H,4-6,8,21H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0460n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396116
PNG
(6-(5-Brom32.2-chloro-pyridin-2-ylmethyl)-5-methyl-...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(Cl)n1
Show InChI InChI=1S/C12H9BrClN5O/c1-5-7(4-6-2-3-8(13)11(14)17-6)9(15)10-12(16-5)19-20-18-10/h2-3H,4,15H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0470n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396164
PNG
(6-(6-Amino-5-thiazol-5-yl-pyridin-2-ylmethyl)-5-me...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(-c2cncs2)c(N)n1
Show InChI InChI=1S/C15H13N7OS/c1-7-10(12(16)13-15(19-7)22-23-21-13)4-8-2-3-9(14(17)20-8)11-5-18-6-24-11/h2-3,5-6H,4,16H2,1H3,(H2,17,20)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0500n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396226
PNG
(6-[5-Bromo-6-(3,3-difluoro-azetidin-1-yl)-pyridin-...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(n1)N1CC(F)(F)C1
Show InChI InChI=1S/C15H13BrF2N6O/c1-7-9(11(19)12-13(20-7)23-25-22-12)4-8-2-3-10(16)14(21-8)24-5-15(17,18)6-24/h2-3H,4-6,19H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0520n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396234
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(n1)N1CC2(COC2)C1
Show InChI InChI=1S/C18H17N7O2/c1-10-13(14(20)15-16(21-10)24-27-23-15)4-12-3-2-11(5-19)17(22-12)25-6-18(7-25)8-26-9-18/h2-3H,4,6-9,20H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0540n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396241
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(NCCC(F)F)n1
Show InChI InChI=1S/C16H15F2N7O/c1-8-11(13(20)14-16(22-8)25-26-24-14)6-10-3-2-9(7-19)15(23-10)21-5-4-12(17)18/h2-3,12H,4-6,20H2,1H3,(H,21,23)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0550n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396221
PNG
(3-[6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyr...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(NCC(C)(C)C(N)=O)n1
Show InChI InChI=1S/C17H20BrN7O2/c1-8-10(12(19)13-15(22-8)25-27-24-13)6-9-4-5-11(18)14(23-9)21-7-17(2,3)16(20)26/h4-5H,6-7,19H2,1-3H3,(H2,20,26)(H,21,23)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0560n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396191
PNG
(1-[6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyr...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(OCC(C)(C)O)n1
Show InChI InChI=1S/C16H18BrN5O3/c1-8-10(12(18)13-14(19-8)22-25-21-13)6-9-4-5-11(17)15(20-9)24-7-16(2,3)23/h4-5,23H,6-7,18H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0580n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396189
PNG
(6-[5-Bromo-6-(2,2-difluoro-ethoxy)-pyridin-2-yl me...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(OCC(F)F)n1
Show InChI InChI=1S/C14H12BrF2N5O2/c1-6-8(11(18)12-13(19-6)22-24-21-12)4-7-2-3-9(15)14(20-7)23-5-10(16)17/h2-3,10H,4-5,18H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0580n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396119
PNG
(6-(5-Brom32.2-fluoro-pyridin-2-ylmethyl)-5-methyl-...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(F)n1
Show InChI InChI=1S/C12H9BrFN5O/c1-5-7(4-6-2-3-8(13)11(14)17-6)9(15)10-12(16-5)19-20-18-10/h2-3H,4,15H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0660n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396196
PNG
(6-[5-Bromo-6-(2,2-difluoro-propoxy)-pyridin-2-ylme...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(OCC(C)(F)F)n1
Show InChI InChI=1S/C15H14BrF2N5O2/c1-7-9(11(19)12-13(20-7)23-25-22-12)5-8-3-4-10(16)14(21-8)24-6-15(2,17)18/h3-4H,5-6,19H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0720n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396139
PNG
(6-(7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C2CC2)c(n1)C#N
Show InChI InChI=1S/C16H14N6O/c1-8-12(14(18)15-16(19-8)22-23-21-15)6-10-4-5-11(9-2-3-9)13(7-17)20-10/h4-5,9H,2-3,6,18H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0730n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396198
PNG
(6-[5-Bromo-6-(3-fluoro-propoxy)-pyridin-2-yl methy...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(OCCCF)n1
Show InChI InChI=1S/C15H15BrFN5O2/c1-8-10(12(18)13-14(19-8)22-24-21-13)7-9-3-4-11(16)15(20-9)23-6-2-5-17/h3-4H,2,5-7,18H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0740n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396199
PNG
(6-(5-Bromo-6-methylsulfanyl-pyridin-2-ylmethyl)-5-...)
Show SMILES CSc1nc(Cc2c(C)nc3nonc3c2N)ccc1Br
Show InChI InChI=1S/C13H12BrN5OS/c1-6-8(10(15)11-12(16-6)19-20-18-11)5-7-3-4-9(14)13(17-7)21-2/h3-4H,5,15H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0740n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396235
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(n1)N1CC(C)(O)C1
Show InChI InChI=1S/C17H17N7O2/c1-9-12(13(19)14-15(20-9)23-26-22-14)5-11-4-3-10(6-18)16(21-11)24-7-17(2,25)8-24/h3-4,25H,5,7-8,19H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0750n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396180
PNG
(6-[5-bromo-4-(trifluoromethyl)pyrimidin-2-yl]methy...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ncc(Br)c(n1)C(F)(F)F
Show InChI InChI=1S/C12H8BrF3N6O/c1-4-5(8(17)9-11(19-4)22-23-21-9)2-7-18-3-6(13)10(20-7)12(14,15)16/h3H,2,17H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0770n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396193
PNG
(6-[5-Bromo-6-(2,2,2-trifluoro-ethoxy)-pyridin-2-yl...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(OCC(F)(F)F)n1
Show InChI InChI=1S/C14H11BrF3N5O2/c1-6-8(10(19)11-12(20-6)23-25-22-11)4-7-2-3-9(15)13(21-7)24-5-14(16,17)18/h2-3H,4-5,19H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0790n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396167
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(OC(F)F)c(n1)C#N
Show InChI InChI=1S/C14H10F2N6O2/c1-6-8(11(18)12-13(19-6)22-24-21-12)4-7-2-3-10(23-14(15)16)9(5-17)20-7/h2-3,14H,4,18H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0820n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396120
PNG
(6-(5-Brom32.2-difluoromethoxy-pyridin-2-ylmethyl)-...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(OC(F)F)n1
Show InChI InChI=1S/C13H10BrF2N5O2/c1-5-7(9(17)10-11(18-5)21-23-20-10)4-6-2-3-8(14)12(19-6)22-13(15)16/h2-3,13H,4,17H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0820n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396192
PNG
(6-[5-Bromo-6-(3-methyl-oxetan-3-ylmethoxy)-pyridin...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(OCC2(C)COC2)n1
Show InChI InChI=1S/C17H18BrN5O3/c1-9-11(13(19)14-15(20-9)23-26-22-14)5-10-3-4-12(18)16(21-10)25-8-17(2)6-24-7-17/h3-4H,5-8,19H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0820n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396215
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Oc2ccccc2)c(n1)C#N
Show InChI InChI=1S/C19H14N6O2/c1-11-14(17(21)18-19(22-11)25-27-24-18)9-12-7-8-16(15(10-20)23-12)26-13-5-3-2-4-6-13/h2-8H,9,21H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0850n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396200
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(OCC(C)(F)F)n1
Show InChI InChI=1S/C16H14F2N6O2/c1-8-11(12(20)13-14(21-8)24-26-23-13)5-10-4-3-9(6-19)15(22-10)25-7-16(2,17)18/h3-4H,5,7,20H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0860n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396216
PNG
(6-(6-Amino-5-difluoromethoxy-pyridin-2-ylmethyl)-5...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(OC(F)F)c(N)n1
Show InChI InChI=1S/C13H12F2N6O2/c1-5-7(9(16)10-12(18-5)21-23-20-10)4-6-2-3-8(11(17)19-6)22-13(14)15/h2-3,13H,4,16H2,1H3,(H2,17,19)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0910n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396206
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(OCC(F)F)n1
Show InChI InChI=1S/C15H12F2N6O2/c1-7-10(12(19)13-14(20-7)23-25-22-13)4-9-3-2-8(5-18)15(21-9)24-6-11(16)17/h2-3,11H,4,6,19H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0930n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396225
PNG
(6-[5-Bromo-6-(3,3-difluoro-cyclobutylamino)-pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(NC2CC(F)(F)C2)n1
Show InChI InChI=1S/C16H15BrF2N6O/c1-7-10(12(20)13-15(21-7)25-26-24-13)4-8-2-3-11(17)14(22-8)23-9-5-16(18,19)6-9/h2-3,9H,4-6,20H2,1H3,(H,22,23)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0960n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396228
PNG
(1-[6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyr...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(n1)N1CCNC(=O)CC1
Show InChI InChI=1S/C17H18BrN7O2/c1-9-11(14(19)15-16(21-9)24-27-23-15)8-10-2-3-12(18)17(22-10)25-6-4-13(26)20-5-7-25/h2-3H,4-8,19H2,1H3,(H,20,26)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0970n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396230
PNG
(6-[5-Bromo-6-(3,3-difluoro-propylamino)-pyridin-2-...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(NCCC(F)F)n1
Show InChI InChI=1S/C15H15BrF2N6O/c1-7-9(12(19)13-15(21-7)24-25-23-13)6-8-2-3-10(16)14(22-8)20-5-4-11(17)18/h2-3,11H,4-6,19H2,1H3,(H,20,22)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0990n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396224
PNG
(3-[6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyr...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(NCC(C)(C)C#N)n1
Show InChI InChI=1S/C17H18BrN7O/c1-9-11(13(20)14-16(22-9)25-26-24-14)6-10-4-5-12(18)15(23-10)21-8-17(2,3)7-19/h4-5H,6,8,20H2,1-3H3,(H,21,23)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396229
PNG
(6-[5-Bromo-6-(3,3-difluoro-pyrrolidin-1-yl)-pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(n1)N1CCC(F)(F)C1
Show InChI InChI=1S/C16H15BrF2N6O/c1-8-10(12(20)13-14(21-8)24-26-23-13)6-9-2-3-11(17)15(22-9)25-5-4-16(18,19)7-25/h2-3H,4-7,20H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396154
PNG
(6-(6-Furan-2-yl-pyridin-2-ylmethyl)-5-methyl-[1,2,...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1cccc(n1)-c1ccco1
Show InChI InChI=1S/C16H13N5O2/c1-9-11(14(17)15-16(18-9)21-23-20-15)8-10-4-2-5-12(19-10)13-6-3-7-22-13/h2-7H,8,17H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396208
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(OCC2(C)COC2)n1
Show InChI InChI=1S/C18H18N6O3/c1-10-13(14(20)15-16(21-10)24-27-23-15)5-12-4-3-11(6-19)17(22-12)26-9-18(2)7-25-8-18/h3-4H,5,7-9,20H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396161
PNG
(1-[6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyr...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1cccc(n1)C1(CCCC1)C#N
Show InChI InChI=1S/C18H18N6O/c1-11-13(15(20)16-17(21-11)24-25-23-16)9-12-5-4-6-14(22-12)18(10-19)7-2-3-8-18/h4-6H,2-3,7-9,20H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396224
PNG
(3-[6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyr...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(NCC(C)(C)C#N)n1
Show InChI InChI=1S/C17H18BrN7O/c1-9-11(13(20)14-16(22-9)25-26-24-14)6-10-4-5-12(18)15(23-10)21-8-17(2,3)7-19/h4-5H,6,8,20H2,1-3H3,(H,21,23)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396203
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(OCCF)n1
Show InChI InChI=1S/C15H13FN6O2/c1-8-11(12(18)13-14(19-8)22-24-21-13)6-10-3-2-9(7-17)15(20-10)23-5-4-16/h2-3H,4-6,18H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.110n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396165
PNG
(6-[6-Amino-5-(2,4-dimethyl-2H-pyrazol-3-yl)-pyridi...)
Show SMILES Cc1cnn(C)c1-c1ccc(Cc2c(C)nc3nonc3c2N)nc1N
Show InChI InChI=1S/C17H18N8O/c1-8-7-20-25(3)15(8)11-5-4-10(22-16(11)19)6-12-9(2)21-17-14(13(12)18)23-26-24-17/h4-5,7H,6,18H2,1-3H3,(H2,19,22)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.110n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396202
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(OCC(C)(C)O)n1
Show InChI InChI=1S/C17H18N6O3/c1-9-12(13(19)14-15(20-9)23-26-22-14)6-11-5-4-10(7-18)16(21-11)25-8-17(2,3)24/h4-5,24H,6,8,19H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.120n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396121
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(Cl)n1
Show InChI InChI=1S/C13H9ClN6O/c1-6-9(10(16)11-13(17-6)20-21-19-11)4-8-3-2-7(5-15)12(14)18-8/h2-3H,4,16H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.120n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396108
PNG
(6-[5-(1,1-Difluoro-ethyl)-pyridin-2-ylmethyl]-5-me...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(cn1)C(C)(F)F
Show InChI InChI=1S/C14H13F2N5O/c1-7-10(11(17)12-13(19-7)21-22-20-12)5-9-4-3-8(6-18-9)14(2,15)16/h3-4,6H,5,17H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.130n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396238
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(n1)N1CCNC(=O)CC1
Show InChI InChI=1S/C18H18N8O2/c1-10-13(15(20)16-17(22-10)25-28-24-16)8-12-3-2-11(9-19)18(23-12)26-6-4-14(27)21-5-7-26/h2-3H,4-8,20H2,1H3,(H,21,27)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.140n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396163
PNG
(6-[6-Amino-5-(3,5-dimethyl-isoxazol-4-yl)-pyridin-...)
Show SMILES Cc1noc(C)c1-c1ccc(Cc2c(C)nc3nonc3c2N)nc1N
Show InChI InChI=1S/C17H17N7O2/c1-7-12(14(18)15-17(20-7)24-26-23-15)6-10-4-5-11(16(19)21-10)13-8(2)22-25-9(13)3/h4-5H,6,18H2,1-3H3,(H2,19,21)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.140n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396237
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(NC2CC(F)(F)C2)n1
Show InChI InChI=1S/C17H15F2N7O/c1-8-12(13(21)14-16(22-8)26-27-25-14)4-10-3-2-9(7-20)15(23-10)24-11-5-17(18,19)6-11/h2-3,11H,4-6,21H2,1H3,(H,23,24)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.150n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396245
PNG
(3-[6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyr...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(NCC(C)(C)C(N)=O)n1
Show InChI InChI=1S/C18H20N8O2/c1-9-12(13(20)14-16(23-9)26-28-25-14)6-11-5-4-10(7-19)15(24-11)22-8-18(2,3)17(21)27/h4-5H,6,8,20H2,1-3H3,(H2,21,27)(H,22,24)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.150n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396146
PNG
(1-[6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyr...)
Show SMILES CC(C)C(=O)c1nc(Cc2c(C)nc3nonc3c2N)ccc1C(F)(F)F
Show InChI InChI=1S/C17H16F3N5O2/c1-7(2)15(26)13-11(17(18,19)20)5-4-9(23-13)6-10-8(3)22-16-14(12(10)21)24-27-25-16/h4-5,7H,6,21H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.150n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396117
PNG
(6-(4-Chloro-5-trifluoromethyl-pyridin-2-ylmethyl)-...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1cc(Cl)c(cn1)C(F)(F)F
Show InChI InChI=1S/C13H9ClF3N5O/c1-5-7(10(18)11-12(20-5)22-23-21-11)2-6-3-9(14)8(4-19-6)13(15,16)17/h3-4H,2,18H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.170n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396141
PNG
(5-Methyl-6-(5-methylsulfanyl-pyridin-2-ylmethyl)-[...)
Show SMILES CSc1ccc(Cc2c(C)nc3nonc3c2N)nc1
Show InChI InChI=1S/C13H13N5OS/c1-7-10(5-8-3-4-9(20-2)6-15-8)11(14)12-13(16-7)18-19-17-12/h3-4,6H,5,14H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.170n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396251
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(NCC(F)F)c(n1)C#N
Show InChI InChI=1S/C15H13F2N7O/c1-7-9(13(19)14-15(21-7)24-25-23-14)4-8-2-3-10(11(5-18)22-8)20-6-12(16)17/h2-3,12,20H,4,6,19H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.170n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396223
PNG
(6-{5-Bromo-6-[(3-methyl-tetrahydro-furan-3-ylmethy...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(NCC2(C)CCOC2)n1
Show InChI InChI=1S/C18H21BrN6O2/c1-10-12(14(20)15-17(22-10)25-27-24-15)7-11-3-4-13(19)16(23-11)21-8-18(2)5-6-26-9-18/h3-4H,5-9,20H2,1-2H3,(H,21,23)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.170n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396136
PNG
(6-[(5-cyclopropylpyridin-2-yl)methyl]-5-methyl-[1,...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(cn1)C1CC1
Show InChI InChI=1S/C15H15N5O/c1-8-12(13(16)14-15(18-8)20-21-19-14)6-11-5-4-10(7-17-11)9-2-3-9/h4-5,7,9H,2-3,6,16H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.180n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396145
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(c(n1)C#N)C(F)(F)F
Show InChI InChI=1S/C14H9F3N6O/c1-6-8(11(19)12-13(20-6)23-24-22-12)4-7-2-3-9(14(15,16)17)10(5-18)21-7/h2-3H,4,19H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.180n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396214
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Oc2ccnn2C)c(n1)C#N
Show InChI InChI=1S/C17H14N8O2/c1-9-11(15(19)16-17(21-9)24-27-23-16)7-10-3-4-13(12(8-18)22-10)26-14-5-6-20-25(14)2/h3-6H,7,19H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.190n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396134
PNG
(6-(7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C(F)F)c(n1)C#N
Show InChI InChI=1S/C14H10F2N6O/c1-6-9(11(18)12-14(19-6)22-23-21-12)4-7-2-3-8(13(15)16)10(5-17)20-7/h2-3,13H,4,18H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.200n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396232
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(NCC2(C)COC2)n1
Show InChI InChI=1S/C18H19N7O2/c1-10-13(14(20)15-17(22-10)25-27-24-15)5-12-4-3-11(6-19)16(23-12)21-7-18(2)8-26-9-18/h3-4H,5,7-9,20H2,1-2H3,(H,21,23)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.200n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396159
PNG
(5-Methyl-6-[6-(3-trifluoromethyl-1H-pyrazol-4-yl)-...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1cccc(n1)-c1c[nH]nc1C(F)(F)F
Show InChI InChI=1S/C16H12F3N7O/c1-7-9(12(20)13-15(22-7)26-27-25-13)5-8-3-2-4-11(23-8)10-6-21-24-14(10)16(17,18)19/h2-4,6H,5,20H2,1H3,(H,21,24)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.210n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396181
PNG
(6-[5-bromo-4-(difluoromethyl)pyrimidin-2-yl]methyl...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ncc(Br)c(n1)C(F)F
Show InChI InChI=1S/C12H9BrF2N6O/c1-4-5(8(16)10-12(18-4)21-22-20-10)2-7-17-3-6(13)9(19-7)11(14)15/h3,11H,2,16H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.210n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396209
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(OCC2CC2(F)F)n1
Show InChI InChI=1S/C17H14F2N6O2/c1-8-12(13(21)14-15(22-8)25-27-24-14)4-11-3-2-9(6-20)16(23-11)26-7-10-5-17(10,18)19/h2-3,10H,4-5,7,21H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.220n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396143
PNG
(2-(7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ncc(c(N)n1)C(F)(F)F
Show InChI InChI=1S/C12H10F3N7O/c1-4-5(8(16)9-11(19-4)22-23-21-9)2-7-18-3-6(10(17)20-7)12(13,14)15/h3H,2,16H2,1H3,(H2,17,18,20)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.220n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396114
PNG
(5-Methyl-6-(5-trifluoromethoxy-pyridin-2-ylmethyl)...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(OC(F)(F)F)cn1
Show InChI InChI=1S/C13H10F3N5O2/c1-6-9(10(17)11-12(19-6)21-23-20-11)4-7-2-3-8(5-18-7)22-13(14,15)16/h2-3,5H,4,17H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.220n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396168
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(n1)C#N
Show InChI InChI=1S/C13H9BrN6O/c1-6-8(11(16)12-13(17-6)20-21-19-12)4-7-2-3-9(14)10(5-15)18-7/h2-3H,4,16H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.220n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396231
PNG
(6-[5-Bromo-6-(3,3,3-trifluoro-propylamino)-pyridin...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(NCCC(F)(F)F)n1
Show InChI InChI=1S/C15H14BrF3N6O/c1-7-9(11(20)12-14(22-7)25-26-24-12)6-8-2-3-10(16)13(23-8)21-5-4-15(17,18)19/h2-3H,4-6,20H2,1H3,(H,21,23)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.240n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396102
PNG
(6-(5-Bromo-pyridin-2-ylmethyl)-5-methyl-[1,2,5]oxa...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)cn1
Show InChI InChI=1S/C12H10BrN5O/c1-6-9(4-8-3-2-7(13)5-15-8)10(14)11-12(16-6)18-19-17-11/h2-3,5H,4,14H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.240n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396151
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES CNC(=O)c1cccc(Cc2c(C)nc3nonc3c2N)n1
Show InChI InChI=1S/C14H14N6O2/c1-7-9(11(15)12-13(17-7)20-22-19-12)6-8-4-3-5-10(18-8)14(21)16-2/h3-5H,6,15H2,1-2H3,(H,16,21)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.240n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396244
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(NCC2(C)CCOC2)n1
Show InChI InChI=1S/C19H21N7O2/c1-11-14(15(21)16-18(23-11)26-28-25-16)7-13-4-3-12(8-20)17(24-13)22-9-19(2)5-6-27-10-19/h3-4H,5-7,9-10,21H2,1-2H3,(H,22,24)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.25n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396254
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(c(n1)C#N)-n1cccn1
Show InChI InChI=1S/C16H12N8O/c1-9-11(14(18)15-16(20-9)23-25-22-15)7-10-3-4-13(12(8-17)21-10)24-6-2-5-19-24/h2-6H,7,18H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.260n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396207
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(OCCC(F)(F)F)n1
Show InChI InChI=1S/C16H13F3N6O2/c1-8-11(12(21)13-14(22-8)25-27-24-13)6-10-3-2-9(7-20)15(23-10)26-5-4-16(17,18)19/h2-3H,4-6,21H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.280n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396113
PNG
(5-Methyl-6-(6-methylsulfanyl-pyridin-2-ylmethyl)-[...)
Show SMILES CSc1cccc(Cc2c(C)nc3nonc3c2N)n1
Show InChI InChI=1S/C13H13N5OS/c1-7-9(6-8-4-3-5-10(16-8)20-2)11(14)12-13(15-7)18-19-17-12/h3-5H,6,14H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.280n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396158
PNG
(5-Methyl-6-[6-(1-methyl-3-trifluoromethyl-1H-pyraz...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1cccc(n1)-c1cn(C)nc1C(F)(F)F
Show InChI InChI=1S/C17H14F3N7O/c1-8-10(13(21)14-16(22-8)26-28-25-14)6-9-4-3-5-12(23-9)11-7-27(2)24-15(11)17(18,19)20/h3-5,7H,6,21H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.290n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396162
PNG
(6-[6-Amino-5-(5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(-c2cnn3CCCc23)c(N)n1
Show InChI InChI=1S/C18H18N8O/c1-9-12(15(19)16-18(22-9)25-27-24-16)7-10-4-5-11(17(20)23-10)13-8-21-26-6-2-3-14(13)26/h4-5,8H,2-3,6-7,19H2,1H3,(H2,20,23)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.290n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396130
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(OC(F)(F)F)c(n1)C#N
Show InChI InChI=1S/C14H9F3N6O2/c1-6-8(11(19)12-13(20-6)23-25-22-12)4-7-2-3-10(9(5-18)21-7)24-14(15,16)17/h2-3H,4,19H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.300n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396242
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(NCCC(F)(F)F)n1
Show InChI InChI=1S/C16H14F3N7O/c1-8-11(12(21)13-15(23-8)26-27-25-13)6-10-3-2-9(7-20)14(24-10)22-5-4-16(17,18)19/h2-3H,4-6,21H2,1H3,(H,22,24)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.320n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396115
PNG
(6-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-6-ylmeth...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc2OCCOc2n1
Show InChI InChI=1S/C14H13N5O3/c1-7-9(11(15)12-13(16-7)19-22-18-12)6-8-2-3-10-14(17-8)21-5-4-20-10/h2-3H,4-6,15H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.320n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396190
PNG
(6-[5-Bromo-6-(2,2-difluoro-cyclopropylmethoxy)-pyr...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(OCC2CC2(F)F)n1
Show InChI InChI=1S/C16H14BrF2N5O2/c1-7-10(12(20)13-14(21-7)24-26-23-13)4-9-2-3-11(17)15(22-9)25-6-8-5-16(8,18)19/h2-3,8H,4-6,20H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.320n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396204
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(OCC(F)(F)F)n1
Show InChI InChI=1S/C15H11F3N6O2/c1-7-10(11(20)12-13(21-7)24-26-23-12)4-9-3-2-8(5-19)14(22-9)25-6-15(16,17)18/h2-3H,4,6,20H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.330n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396170
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(OC(F)F)n1
Show InChI InChI=1S/C14H10F2N6O2/c1-6-9(10(18)11-12(19-6)22-24-21-11)4-8-3-2-7(5-17)13(20-8)23-14(15)16/h2-3,14H,4,18H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.330n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396156
PNG
(5-Methyl-6-[6-(3-methyl-3H-imidazol-4-yl)-pyridin-...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1cccc(n1)-c1cncn1C
Show InChI InChI=1S/C16H15N7O/c1-9-11(14(17)15-16(19-9)22-24-21-15)6-10-4-3-5-12(20-10)13-7-18-8-23(13)2/h3-5,7-8H,6,17H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.340n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396188
PNG
(6-[5-Bromo-6-(3,3,3-trifluoro-propoxy)-pyridin-2-y...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(OCCC(F)(F)F)n1
Show InChI InChI=1S/C15H13BrF3N5O2/c1-7-9(11(20)12-13(21-7)24-26-23-12)6-8-2-3-10(16)14(22-8)25-5-4-15(17,18)19/h2-3H,4-6,20H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.350n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396175
PNG
(2-(7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ncc(C#N)c(n1)C(F)(F)F
Show InChI InChI=1S/C13H8F3N7O/c1-5-7(9(18)10-12(20-5)23-24-22-10)2-8-19-4-6(3-17)11(21-8)13(14,15)16/h4H,2,18H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.360n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396140
PNG
(6-(7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(n1)C1CC1
Show InChI InChI=1S/C16H14N6O/c1-8-12(13(18)15-16(19-8)22-23-21-15)6-11-5-4-10(7-17)14(20-11)9-2-3-9/h4-5,9H,2-3,6,18H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.370n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396263
PNG
(6-[5-chloro-4-(difluoromethyl)pyrimidin-2-yl]methy...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ncc(Cl)c(n1)C(F)F
Show InChI InChI=1S/C12H9ClF2N6O/c1-4-5(8(16)10-12(18-4)21-22-20-10)2-7-17-3-6(13)9(19-7)11(14)15/h3,11H,2,16H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.380n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396105
PNG
(6-(5-Chloro-pyridin-2-ylmethyl)-5-methyl-[1,2,5]ox...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Cl)cn1
Show InChI InChI=1S/C12H10ClN5O/c1-6-9(4-8-3-2-7(13)5-15-8)10(14)11-12(16-6)18-19-17-11/h2-3,5H,4,14H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.420n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396186
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(c(n1)C(N)=O)C(F)(F)F
Show InChI InChI=1S/C14H11F3N6O2/c1-5-7(9(18)11-13(20-5)23-25-22-11)4-6-2-3-8(14(15,16)17)10(21-6)12(19)24/h2-3H,4,18H2,1H3,(H2,19,24)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.430n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396129
PNG
(6-(5-Bromo-4-trifluoromethyl-pyridin-2-ylmethyl)-5...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1cc(c(Br)cn1)C(F)(F)F
Show InChI InChI=1S/C13H9BrF3N5O/c1-5-7(10(18)11-12(20-5)22-23-21-11)2-6-3-8(13(15,16)17)9(14)4-19-6/h3-4H,2,18H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.440n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396106
PNG
(6-(5-Difluoromethyl-pyridin-2-ylmethyl)-5-methyl-[...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(cn1)C(F)F
Show InChI InChI=1S/C13H11F2N5O/c1-6-9(10(16)11-13(18-6)20-21-19-11)4-8-3-2-7(5-17-8)12(14)15/h2-3,5,12H,4,16H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.440n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396100
PNG
(6-(6-Chloro-pyridin-2-ylmethyl)-5-methyl-[1,2,5]ox...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1cccc(Cl)n1
Show InChI InChI=1S/C12H10ClN5O/c1-6-8(5-7-3-2-4-9(13)16-7)10(14)11-12(15-6)18-19-17-11/h2-4H,5,14H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.460n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396157
PNG
(6-[6-(3,5-Dimethyl-isoxazol-4-yl)-pyridin-2-ylmeth...)
Show SMILES Cc1noc(C)c1-c1cccc(Cc2c(C)nc3nonc3c2N)n1
Show InChI InChI=1S/C17H16N6O2/c1-8-12(15(18)16-17(19-8)23-25-22-16)7-11-5-4-6-13(20-11)14-9(2)21-24-10(14)3/h4-6H,7,18H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.480n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396149
PNG
(5-Methyl-6-(6-trifluoromethyl-pyridin-2-ylmethyl)-...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1cccc(n1)C(F)(F)F
Show InChI InChI=1S/C13H10F3N5O/c1-6-8(10(17)11-12(18-6)21-22-20-11)5-7-3-2-4-9(19-7)13(14,15)16/h2-4H,5,17H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.480n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396160
PNG
(2-[6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyr...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1cccc(n1)C(C)(C)C#N
Show InChI InChI=1S/C16H16N6O/c1-9-11(13(18)14-15(19-9)22-23-21-14)7-10-5-4-6-12(20-10)16(2,3)8-17/h4-6H,7,18H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.480n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396187
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(OC(F)F)c(n1)C(N)=O
Show InChI InChI=1S/C14H12F2N6O3/c1-5-7(9(17)11-13(19-5)22-25-21-11)4-6-2-3-8(24-14(15)16)10(20-6)12(18)23/h2-3,14H,4,17H2,1H3,(H2,18,23)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.540n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396250
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(NCCF)c(n1)C#N
Show InChI InChI=1S/C15H14FN7O/c1-8-10(13(18)14-15(20-8)23-24-22-14)6-9-2-3-11(19-5-4-16)12(7-17)21-9/h2-3,19H,4-6,18H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.560n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396166
PNG
(6-(6-Amino-5-pyrazin-2-yl-pyridin-2-ylmethyl)-5-me...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(c(N)n1)-c1cnccn1
Show InChI InChI=1S/C16H14N8O/c1-8-11(13(17)14-16(21-8)24-25-23-14)6-9-2-3-10(15(18)22-9)12-7-19-4-5-20-12/h2-5,7H,6,17H2,1H3,(H2,18,22)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.580n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396176
PNG
(2-(7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ncc(C#N)c(n1)C(F)F
Show InChI InChI=1S/C13H9F2N7O/c1-5-7(9(17)11-13(19-5)22-23-21-11)2-8-18-4-6(3-16)10(20-8)12(14)15/h4,12H,2,17H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.590n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396249
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(N2CCOCC2)c(n1)C#N
Show InChI InChI=1S/C17H17N7O2/c1-10-12(15(19)16-17(20-10)23-26-22-16)8-11-2-3-14(13(9-18)21-11)24-4-6-25-7-5-24/h2-3H,4-8,19H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.600n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396103
PNG
(5-Methyl-6-(5-trifluoromethyl-pyridin-2-ylmethyl)-...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C13H10F3N5O/c1-6-9(10(17)11-12(19-6)21-22-20-11)4-8-3-2-7(5-18-8)13(14,15)16/h2-3,5H,4,17H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.610n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396111
PNG
(6-(5-Difluoromethoxy-pyridin-2-ylmethyl)-5-methyl-...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(OC(F)F)cn1
Show InChI InChI=1S/C13H11F2N5O2/c1-6-9(10(16)11-12(18-6)20-22-19-11)4-7-2-3-8(5-17-7)21-13(14)15/h2-3,5,13H,4,16H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.670n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396153
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1cccc(n1)C(N)=O
Show InChI InChI=1S/C13H12N6O2/c1-6-8(10(14)11-13(16-6)19-21-18-11)5-7-3-2-4-9(17-7)12(15)20/h2-4H,5,14H2,1H3,(H2,15,20)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.720n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396264
PNG
(6-[5-chloro-4,6-bis(difluoromethyl)pyrimidin-2-yl]...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1nc(C(F)F)c(Cl)c(n1)C(F)F
Show InChI InChI=1S/C13H9ClF4N6O/c1-3-4(7(19)10-13(20-3)24-25-23-10)2-5-21-8(11(15)16)6(14)9(22-5)12(17)18/h11-12H,2,19H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.820n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396213
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(OCC(F)F)c(n1)C#N
Show InChI InChI=1S/C15H12F2N6O2/c1-7-9(13(19)14-15(20-7)23-25-22-14)4-8-2-3-11(10(5-18)21-8)24-6-12(16)17/h2-3,12H,4,6,19H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.830n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396258
PNG
(6-(5-Bromo-6-methanesulfonyl-pyridin-2-ylmethyl)-5...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(n1)S(C)(=O)=O
Show InChI InChI=1S/C13H12BrN5O3S/c1-6-8(10(15)11-12(16-6)19-22-18-11)5-7-3-4-9(14)13(17-7)23(2,20)21/h3-4H,5,15H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.890n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396104
PNG
(6-(6-Bromo-pyridin-2-ylmethyl)-5-methyl-[1,2,5]oxa...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1cccc(Br)n1
Show InChI InChI=1S/C12H10BrN5O/c1-6-8(5-7-3-2-4-9(13)16-7)10(14)11-12(15-6)18-19-17-11/h2-4H,5,14H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.950n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396201
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(OC2COC2)n1
Show InChI InChI=1S/C16H14N6O3/c1-8-12(13(18)14-15(19-8)22-25-21-14)4-10-3-2-9(5-17)16(20-10)24-11-6-23-7-11/h2-3,11H,4,6-7,18H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.980n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396179
PNG
(2-(7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ncc(C#N)c(n1)C(C)(F)F
Show InChI InChI=1S/C14H11F2N7O/c1-6-8(10(18)11-13(20-6)23-24-22-11)3-9-19-5-7(4-17)12(21-9)14(2,15)16/h5H,3,18H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396169
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(F)n1
Show InChI InChI=1S/C13H9FN6O/c1-6-9(10(16)11-13(17-6)20-21-19-11)4-8-3-2-7(5-15)12(14)18-8/h2-3H,4,16H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396243
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(NCC(C)(C)C#N)n1
Show InChI InChI=1S/C18H18N8O/c1-10-13(14(21)15-17(23-10)26-27-25-15)6-12-5-4-11(7-19)16(24-12)22-9-18(2,3)8-20/h4-5H,6,9,21H2,1-3H3,(H,22,24)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396142
PNG
(4-amino-2-(7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-...)
Show SMILES CN(C)\C=N\c1nc(Cc2c(C)nc3nonc3c2N)ncc1C#N
Show InChI InChI=1S/C15H15N9O/c1-8-10(12(17)13-15(20-8)23-25-22-13)4-11-18-6-9(5-16)14(21-11)19-7-24(2)3/h6-7H,4,17H2,1-3H3/b19-7+
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396138
PNG
(6-[(5-cyclopropoxypyridin-2-yl)methyl]-5-methyl-[1...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(OC2CC2)cn1
Show InChI InChI=1S/C15H15N5O2/c1-8-12(13(16)14-15(18-8)20-22-19-14)6-9-2-3-11(7-17-9)21-10-4-5-10/h2-3,7,10H,4-6,16H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396252
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(c(n1)C#N)-n1cc(F)cn1
Show InChI InChI=1S/C16H11FN8O/c1-8-11(14(19)15-16(21-8)24-26-23-15)4-10-2-3-13(12(5-18)22-10)25-7-9(17)6-20-25/h2-3,6-7H,4,19H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396212
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(OCCF)c(n1)C#N
Show InChI InChI=1S/C15H13FN6O2/c1-8-10(13(18)14-15(19-8)22-24-21-14)6-9-2-3-12(23-5-4-16)11(7-17)20-9/h2-3H,4-6,18H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396096
PNG
(6-(5-Methoxy-pyridin-2-ylmethyl)-5-methyl-[1,2,5]o...)
Show SMILES COc1ccc(Cc2c(C)nc3nonc3c2N)nc1
Show InChI InChI=1S/C13H13N5O2/c1-7-10(5-8-3-4-9(19-2)6-15-8)11(14)12-13(16-7)18-20-17-12/h3-4,6H,5,14H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.40n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396255
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(n1)C#N
Show InChI InChI=1S/C14H9N7O/c1-7-10(12(17)13-14(18-7)21-22-20-13)4-9-3-2-8(5-15)11(6-16)19-9/h2-3H,4,17H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.70n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396124
PNG
(2-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1cc(C#N)c(Br)cn1
Show InChI InChI=1S/C13H9BrN6O/c1-6-9(11(16)12-13(18-6)20-21-19-12)3-8-2-7(4-15)10(14)5-17-8/h2,5H,3,16H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.70n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396101
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(cn1)C#N
Show InChI InChI=1S/C13H10N6O/c1-7-10(4-9-3-2-8(5-14)6-16-9)11(15)12-13(17-7)19-20-18-12/h2-3,6H,4,15H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.70n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396248
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(N2CC(F)(F)C2)c(n1)C#N
Show InChI InChI=1S/C16H13F2N7O/c1-8-10(13(20)14-15(21-8)24-26-23-14)4-9-2-3-12(11(5-19)22-9)25-6-16(17,18)7-25/h2-3H,4,6-7,20H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.80n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396132
PNG
(5-methyl-6-[5-(trifluoromethyl)pyrimidin-2-yl]meth...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ncc(cn1)C(F)(F)F
Show InChI InChI=1S/C12H9F3N6O/c1-5-7(9(16)10-11(19-5)21-22-20-10)2-8-17-3-6(4-18-8)12(13,14)15/h3-4H,2,16H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.80n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396128
PNG
(6-(5-Bromo-pyrimidin-2-ylmethyl)-5-methyl-[1,2,5]o...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ncc(Br)cn1
Show InChI InChI=1S/C11H9BrN6O/c1-5-7(2-8-14-3-6(12)4-15-8)9(13)10-11(16-5)18-19-17-10/h3-4H,2,13H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.80n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396195
PNG
(6-[5-Bromo-6-(oxetan-3-yloxy)-pyridin-2-yl methyl]...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(OC2COC2)n1
Show InChI InChI=1S/C15H14BrN5O3/c1-7-10(12(17)13-14(18-7)21-24-20-13)4-8-2-3-11(16)15(19-8)23-9-5-22-6-9/h2-3,9H,4-6,17H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.90n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396171
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1cc(c(cn1)C#N)C(F)(F)F
Show InChI InChI=1S/C14H9F3N6O/c1-6-9(11(19)12-13(21-6)23-24-22-12)2-8-3-10(14(15,16)17)7(4-18)5-20-8/h3,5H,2,19H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396247
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(N2CCC(F)(F)C2)c(n1)C#N
Show InChI InChI=1S/C17H15F2N7O/c1-9-11(14(21)15-16(22-9)25-27-24-15)6-10-2-3-13(12(7-20)23-10)26-5-4-17(18,19)8-26/h2-3H,4-6,8,21H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.30n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396144
PNG
(6-(7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Cl)c(n1)C#N
Show InChI InChI=1S/C13H9ClN6O/c1-6-8(11(16)12-13(17-6)20-21-19-12)4-7-2-3-9(14)10(5-15)18-7/h2-3H,4,16H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.40n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396147
PNG
(6-[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]meth...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ncc(c(Cl)n1)C(F)(F)F
Show InChI InChI=1S/C12H8ClF3N6O/c1-4-5(8(17)9-11(19-4)22-23-21-9)2-7-18-3-6(10(13)20-7)12(14,15)16/h3H,2,17H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.5n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396260
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(=O)[nH]1
Show InChI InChI=1S/C12H10BrN5O2/c1-5-7(4-6-2-3-8(13)12(19)16-6)9(14)10-11(15-5)18-20-17-10/h2-3H,4,14H2,1H3,(H,16,19)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.5n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396135
PNG
(6-(7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1cc(Cl)cc(n1)C#N
Show InChI InChI=1S/C13H9ClN6O/c1-6-10(11(16)12-13(17-6)20-21-19-12)4-8-2-7(14)3-9(5-15)18-8/h2-3H,4,16H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.60n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396150
PNG
(5-Methyl-6-(6-methyl-pyridin-2-yl methyl)-[1,2,5]o...)
Show SMILES Cc1cccc(Cc2c(C)nc3nonc3c2N)n1
Show InChI InChI=1S/C13H13N5O/c1-7-4-3-5-9(15-7)6-10-8(2)16-13-12(11(10)14)17-19-18-13/h3-5H,6,14H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.60n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396172
PNG
(2-(7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ncc(c(n1)C#N)C(F)(F)F
Show InChI InChI=1S/C13H8F3N7O/c1-5-6(10(18)11-12(20-5)23-24-22-11)2-9-19-4-7(13(14,15)16)8(3-17)21-9/h4H,2,18H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.70n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396127
PNG
(6-(5-Chloro-pyrimidin-2-ylmethyl)-5-methyl-[1,2,5]...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ncc(Cl)cn1
Show InChI InChI=1S/C11H9ClN6O/c1-5-7(2-8-14-3-6(12)4-15-8)9(13)10-11(16-5)18-19-17-10/h3-4H,2,13H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.70n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396155
PNG
(5-methyl-6-[(pyridin-2-yl)methyl]-[1,2,5]oxadiazol...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccccn1
Show InChI InChI=1S/C12H11N5O/c1-7-9(6-8-4-2-3-5-14-8)10(13)11-12(15-7)17-18-16-11/h2-5H,6,13H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.80n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396257
PNG
(6-(5,6-Bis-methanesulfonyl-pyridin-2-ylmethyl)-5-m...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(c(n1)S(C)(=O)=O)S(C)(=O)=O
Show InChI InChI=1S/C14H15N5O5S2/c1-7-9(11(15)12-13(16-7)19-24-18-12)6-8-4-5-10(25(2,20)21)14(17-8)26(3,22)23/h4-5H,6,15H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396131
PNG
(5-Methyl-6-(4-trifluoromethyl-pyrimidin-2-ylmethyl...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1nccc(n1)C(F)(F)F
Show InChI InChI=1S/C12H9F3N6O/c1-5-6(9(16)10-11(18-5)21-22-20-10)4-8-17-3-2-7(19-8)12(13,14)15/h2-3H,4,16H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.20n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396185
PNG
(6-(5-Methanesulfonyl-pyridin-2-ylmethyl)-5-methyl-...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(cn1)S(C)(=O)=O
Show InChI InChI=1S/C13H13N5O3S/c1-7-10(11(14)12-13(16-7)18-21-17-12)5-8-3-4-9(6-15-8)22(2,19)20/h3-4,6H,5,14H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.30n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396253
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(c(n1)C#N)-n1ccc(n1)C(F)(F)F
Show InChI InChI=1S/C17H11F3N8O/c1-8-10(14(22)15-16(23-8)27-29-26-15)6-9-2-3-12(11(7-21)24-9)28-5-4-13(25-28)17(18,19)20/h2-5H,6,22H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.5n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396099
PNG
(2-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1cc(C#N)c(cn1)C(F)(F)F
Show InChI InChI=1S/C14H9F3N6O/c1-6-9(11(19)12-13(21-6)23-24-22-12)3-8-2-7(4-18)10(5-20-8)14(15,16)17/h2,5H,3,19H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.60n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396174
PNG
(2-(7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ncc(cn1)C#N
Show InChI InChI=1S/C12H9N7O/c1-6-8(2-9-15-4-7(3-13)5-16-9)10(14)11-12(17-6)19-20-18-11/h4-5H,2,14H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.80n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396177
PNG
(2-(7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ncc(C#N)c(n1)C1CCOC1
Show InChI InChI=1S/C16H15N7O2/c1-8-11(13(18)15-16(20-8)23-25-22-15)4-12-19-6-10(5-17)14(21-12)9-2-3-24-7-9/h6,9H,2-4,7,18H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.80n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396211
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(OCC(F)(F)F)c(n1)C#N
Show InChI InChI=1S/C15H11F3N6O2/c1-7-9(12(20)13-14(21-7)24-26-23-13)4-8-2-3-11(10(5-19)22-8)25-6-15(16,17)18/h2-3H,4,6,20H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.90n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396152
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES CN(C)C(=O)c1cccc(Cc2c(C)nc3nonc3c2N)n1
Show InChI InChI=1S/C15H16N6O2/c1-8-10(12(16)13-14(17-8)20-23-19-13)7-9-5-4-6-11(18-9)15(22)21(2)3/h4-6H,7,16H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.90n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396217
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(OC(F)F)c(=O)[nH]1
Show InChI InChI=1S/C13H11F2N5O3/c1-5-7(9(16)10-11(17-5)20-23-19-10)4-6-2-3-8(12(21)18-6)22-13(14)15/h2-3,13H,4,16H2,1H3,(H,18,21)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.30n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396122
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(F)c(n1)C#N
Show InChI InChI=1S/C13H9FN6O/c1-6-8(11(16)12-13(17-6)20-21-19-12)4-7-2-3-9(14)10(5-15)18-7/h2-3H,4,16H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.40n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396110
PNG
(6-(6-Fluoro-pyridin-2-ylmethyl)-5-methyl-[1,2,5]ox...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1cccc(F)n1
Show InChI InChI=1S/C12H10FN5O/c1-6-8(5-7-3-2-4-9(13)16-7)10(14)11-12(15-6)18-19-17-11/h2-4H,5,14H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.40n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396259
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(n1)S(C)(=O)=O
Show InChI InChI=1S/C14H12N6O3S/c1-7-10(11(16)12-13(17-7)20-23-19-12)5-9-4-3-8(6-15)14(18-9)24(2,21)22/h3-4H,5,16H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.60n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396137
PNG
(6-[(5-cyclopropylpyridin-2-yl)methyl]-5-methyl-[1,...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1cc(C#N)c(cn1)C1CC1
Show InChI InChI=1S/C16H14N6O/c1-8-12(14(18)15-16(20-8)22-23-21-15)5-11-4-10(6-17)13(7-19-11)9-2-3-9/h4,7,9H,2-3,5,18H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.20n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396109
PNG
(6-(5-Fluoro-pyridin-2-ylmethyl)-5-methyl-[1,2,5]ox...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(F)cn1
Show InChI InChI=1S/C12H10FN5O/c1-6-9(4-8-3-2-7(13)5-15-8)10(14)11-12(16-6)18-19-17-11/h2-3,5H,4,14H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.5n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396133
PNG
(6-(7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1cc(cc(n1)C#N)C(F)(F)F
Show InChI InChI=1S/C14H9F3N6O/c1-6-10(11(19)12-13(20-6)23-24-22-12)4-8-2-7(14(15,16)17)3-9(5-18)21-8/h2-3H,4,19H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.90n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396182
PNG
(6-(6-Methanesulfinyl-pyridin-2-ylmethyl)-5-methyl-...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1cccc(n1)S(C)=O
Show InChI InChI=1S/C13H13N5O2S/c1-7-9(11(14)12-13(15-7)18-20-17-12)6-8-4-3-5-10(16-8)21(2)19/h3-5H,6,14H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.90n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396178
PNG
(2-(7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc(Cc2c(C)nc3nonc3c2N)ncc1C#N
Show InChI InChI=1S/C13H11N7O/c1-6-8(4-14)5-16-10(17-6)3-9-7(2)18-13-12(11(9)15)19-21-20-13/h5H,3,15H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396261
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES CN(C)\C=N\c1c(I)c(C)nc2nonc12
Show InChI InChI=1S/C9H10IN5O/c1-5-6(10)7(11-4-15(2)3)8-9(12-5)14-16-13-8/h4H,1-3H3/b11-4+
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.40n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396123
PNG
(5-Methyl-6-(4-trifluoromethyl-pyridin-2-ylmethyl)-...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1cc(ccn1)C(F)(F)F
Show InChI InChI=1S/C13H10F3N5O/c1-6-9(10(17)11-12(19-6)21-22-20-11)5-8-4-7(2-3-18-8)13(14,15)16/h2-4H,5,17H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8.80n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396184
PNG
(6-(5-Methanesulfinyl-pyridin-2-ylmethyl)-5-methyl-...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(cn1)S(C)=O
Show InChI InChI=1S/C13H13N5O2S/c1-7-10(11(14)12-13(16-7)18-20-17-12)5-8-3-4-9(6-15-8)21(2)19/h3-4,6H,5,14H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 9n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396107
PNG
(US10308667, Example 10 | [6-(7-Amino-5-methyl-[1,2...)
Show SMILES COC(=O)Cc1ccc(Cc2c(C)nc3nonc3c2N)nc1
Show InChI InChI=1S/C15H15N5O3/c1-8-11(13(16)14-15(18-8)20-23-19-14)6-10-4-3-9(7-17-10)5-12(21)22-2/h3-4,7H,5-6,16H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 13n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396262
PNG
(2-(7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1nc(cc(n1)C(F)F)C#N
Show InChI InChI=1S/C13H9F2N7O/c1-5-7(10(17)11-13(18-5)22-23-21-11)3-9-19-6(4-16)2-8(20-9)12(14)15/h2,12H,3,17H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 14n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396173
PNG
(6-(7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1cc(C#N)c(cn1)C#N
Show InChI InChI=1S/C14H9N7O/c1-7-11(12(17)13-14(19-7)21-22-20-13)3-10-2-8(4-15)9(5-16)6-18-10/h2,6H,3,17H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 14n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396256
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(c(O)n1)S(C)(=O)=O
Show InChI InChI=1S/C13H13N5O4S/c1-6-8(10(14)11-12(15-6)18-22-17-11)5-7-3-4-9(13(19)16-7)23(2,20)21/h3-4H,5,14H2,1-2H3,(H,16,19)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 15n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396126
PNG
(2-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1cc(ccn1)C(N)=O
Show InChI InChI=1S/C13H12N6O2/c1-6-9(10(14)11-13(17-6)19-21-18-11)5-8-4-7(12(15)20)2-3-16-8/h2-4H,5,14H2,1H3,(H2,15,20)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 16n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396183
PNG
(6-(6-Methanesulfonyl-pyridin-2-ylmethyl)-5-methyl-...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1cccc(n1)S(C)(=O)=O
Show InChI InChI=1S/C13H13N5O3S/c1-7-9(11(14)12-13(15-7)18-21-17-12)6-8-4-3-5-10(16-8)22(2,19)20/h3-5H,6,14H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 19n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396148
PNG
(2-(7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1nccc(n1)C#N
Show InChI InChI=1S/C12H9N7O/c1-6-8(4-9-15-3-2-7(5-13)17-9)10(14)11-12(16-6)19-20-18-11/h2-3H,4,14H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396210
PNG
(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(=O)[nH]1
Show InChI InChI=1S/C13H10N6O2/c1-6-9(10(15)11-12(16-6)19-21-18-11)4-8-3-2-7(5-14)13(20)17-8/h2-3H,4,15H2,1H3,(H,17,20)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 31n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))
BDBM396125
PNG
(2-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Show SMILES Cc1nc2nonc2c(N)c1Cc1cc(ccn1)C#N
Show InChI InChI=1S/C13H10N6O/c1-7-10(5-9-4-8(6-14)2-3-16-9)11(15)12-13(17-7)19-20-18-12/h2-4H,5,15H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 48n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37 C., 5% CO2 in DMEM medium, 10% FCS,...


US Patent US10308667 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%