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Patent code US10314832

Compile Data Set for Download or QSAR
Found 18 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Catenin beta-1


(Homo sapiens (Human))
BDBM396286
PNG
(US10314832, Compound 2)
Show SMILES O=C(CCC(=O)c1ccccn1)c1ccc2OCCOc2c1
Show InChI InChI=1S/C17H15NO4/c19-14(5-6-15(20)13-3-1-2-8-18-13)12-4-7-16-17(11-12)22-10-9-21-16/h1-4,7-8,11H,5-6,9-10H2
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n/an/a 13n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of ca...


US Patent US10314832 (2019)


BindingDB Entry DOI: 10.7270/Q2M047TC
More data for this
Ligand-Target Pair
Catenin beta-1


(Homo sapiens (Human))
BDBM396284
PNG
(US10314832, Compound 1)
Show SMILES O=C(CCC(=O)c1ccc2OCCOc2c1)c1ccccc1
Show InChI InChI=1S/C18H16O4/c19-15(13-4-2-1-3-5-13)7-8-16(20)14-6-9-17-18(12-14)22-11-10-21-17/h1-6,9,12H,7-8,10-11H2
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n/an/a 28.5n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of ca...


US Patent US10314832 (2019)


BindingDB Entry DOI: 10.7270/Q2M047TC
More data for this
Ligand-Target Pair
Catenin beta-1


(Homo sapiens (Human))
BDBM396287
PNG
(US10314832, Compound 3)
Show SMILES O=C(CCC(=O)c1ccc2OCCOc2c1)c1cccs1
Show InChI InChI=1S/C16H14O4S/c17-12(4-5-13(18)16-2-1-9-21-16)11-3-6-14-15(10-11)20-8-7-19-14/h1-3,6,9-10H,4-5,7-8H2
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n/an/a 38.5n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of ca...


US Patent US10314832 (2019)


BindingDB Entry DOI: 10.7270/Q2M047TC
More data for this
Ligand-Target Pair
Catenin beta-1


(Homo sapiens (Human))
BDBM396292
PNG
(US10314832, Compound 8)
Show SMILES Oc1ccccc1C(=O)CCC(=O)c1ccc2OCCOc2c1
Show InChI InChI=1S/C18H16O5/c19-14(6-7-16(21)13-3-1-2-4-15(13)20)12-5-8-17-18(11-12)23-10-9-22-17/h1-5,8,11,20H,6-7,9-10H2
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n/an/a 83n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of ca...


US Patent US10314832 (2019)


BindingDB Entry DOI: 10.7270/Q2M047TC
More data for this
Ligand-Target Pair
Catenin beta-1


(Homo sapiens (Human))
BDBM396291
PNG
(US10314832, Compound 7)
Show SMILES Fc1ccc(cc1)C(=O)CCC(=O)c1ccc2OCCOc2c1
Show InChI InChI=1S/C18H15FO4/c19-14-4-1-12(2-5-14)15(20)6-7-16(21)13-3-8-17-18(11-13)23-10-9-22-17/h1-5,8,11H,6-7,9-10H2
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n/an/a 183n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of ca...


US Patent US10314832 (2019)


BindingDB Entry DOI: 10.7270/Q2M047TC
More data for this
Ligand-Target Pair
Catenin beta-1


(Homo sapiens (Human))
BDBM396288
PNG
(US10314832, Compound 11 | US10314832, Compound 4)
Show SMILES COCCOCOc1ccc(cc1)C(=O)CCC(=O)c1ccc2OCCOc2c1
Show InChI InChI=1S/C22H24O7/c1-25-10-11-26-15-29-18-5-2-16(3-6-18)19(23)7-8-20(24)17-4-9-21-22(14-17)28-13-12-27-21/h2-6,9,14H,7-8,10-13,15H2,1H3
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n/an/a 805n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of ca...


US Patent US10314832 (2019)


BindingDB Entry DOI: 10.7270/Q2M047TC
More data for this
Ligand-Target Pair
Catenin beta-1


(Homo sapiens (Human))
BDBM396289
PNG
(US10314832, Compound 5)
Show SMILES O=C(CCC(=O)c1ccccn1)c1cccs1
Show InChI InChI=1S/C13H11NO2S/c15-11(10-4-1-2-8-14-10)6-7-12(16)13-5-3-9-17-13/h1-5,8-9H,6-7H2
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n/an/a 1.27E+3n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of ca...


US Patent US10314832 (2019)


BindingDB Entry DOI: 10.7270/Q2M047TC
More data for this
Ligand-Target Pair
Catenin beta-1


(Homo sapiens (Human))
BDBM396298
PNG
(US10314832, Compound 15)
Show SMILES O=C(CC(=O)c1ccccn1)c1ccc2OCCOc2c1
Show InChI InChI=1S/C16H13NO4/c18-13(10-14(19)12-3-1-2-6-17-12)11-4-5-15-16(9-11)21-8-7-20-15/h1-6,9H,7-8,10H2
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n/an/a 1.39E+3n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of ca...


US Patent US10314832 (2019)


BindingDB Entry DOI: 10.7270/Q2M047TC
More data for this
Ligand-Target Pair
Catenin beta-1


(Homo sapiens (Human))
BDBM396290
PNG
(US10314832, Compound 6)
Show SMILES Oc1cccc(c1)C(=O)CCC(=O)c1ccc2OCCOc2c1
Show InChI InChI=1S/C18H16O5/c19-14-3-1-2-12(10-14)15(20)5-6-16(21)13-4-7-17-18(11-13)23-9-8-22-17/h1-4,7,10-11,19H,5-6,8-9H2
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n/an/a 2.10E+3n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of ca...


US Patent US10314832 (2019)


BindingDB Entry DOI: 10.7270/Q2M047TC
More data for this
Ligand-Target Pair
Catenin beta-1


(Homo sapiens (Human))
BDBM396299
PNG
(US10314832, Compound 16)
Show SMILES O=C(CC(=O)c1ccc2OCCOc2c1)c1cccs1
Show InChI InChI=1S/C15H12O4S/c16-11(9-12(17)15-2-1-7-20-15)10-3-4-13-14(8-10)19-6-5-18-13/h1-4,7-8H,5-6,9H2
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n/an/a 2.57E+3n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of ca...


US Patent US10314832 (2019)


BindingDB Entry DOI: 10.7270/Q2M047TC
More data for this
Ligand-Target Pair
Catenin beta-1


(Homo sapiens (Human))
BDBM396302
PNG
(US10314832, Compound 19)
Show SMILES O=C(C(Cc1cccc2ccccc12)C(=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H20O2/c27-25(20-11-3-1-4-12-20)24(26(28)21-13-5-2-6-14-21)18-22-16-9-15-19-10-7-8-17-23(19)22/h1-17,24H,18H2
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n/an/a 3.90E+3n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of ca...


US Patent US10314832 (2019)


BindingDB Entry DOI: 10.7270/Q2M047TC
More data for this
Ligand-Target Pair
Catenin beta-1


(Homo sapiens (Human))
BDBM396301
PNG
(US10314832, Compound 18)
Show SMILES CCC(CC)(C(=O)c1ccccc1)C(=O)c1ccc2OCCOc2c1
Show InChI InChI=1S/C21H22O4/c1-3-21(4-2,19(22)15-8-6-5-7-9-15)20(23)16-10-11-17-18(14-16)25-13-12-24-17/h5-11,14H,3-4,12-13H2,1-2H3
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n/an/a 6.00E+3n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of ca...


US Patent US10314832 (2019)


BindingDB Entry DOI: 10.7270/Q2M047TC
More data for this
Ligand-Target Pair
Catenin beta-1


(Homo sapiens (Human))
BDBM396300
PNG
(US10314832, Compound 17)
Show SMILES CCC(C(=O)c1ccccc1)C(=O)c1ccc2OCCOc2c1
Show InChI InChI=1S/C19H18O4/c1-2-15(18(20)13-6-4-3-5-7-13)19(21)14-8-9-16-17(12-14)23-11-10-22-16/h3-9,12,15H,2,10-11H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of ca...


US Patent US10314832 (2019)


BindingDB Entry DOI: 10.7270/Q2M047TC
More data for this
Ligand-Target Pair
Catenin beta-1


(Homo sapiens (Human))
BDBM396297
PNG
(US10314832, Compound 14)
Show SMILES O=C(CCC(=O)c1ccc2OCCOc2c1)c1ccc2OCCOc2c1
Show InChI InChI=1S/C20H18O6/c21-15(13-1-5-17-19(11-13)25-9-7-23-17)3-4-16(22)14-2-6-18-20(12-14)26-10-8-24-18/h1-2,5-6,11-12H,3-4,7-10H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of ca...


US Patent US10314832 (2019)


BindingDB Entry DOI: 10.7270/Q2M047TC
More data for this
Ligand-Target Pair
Catenin beta-1


(Homo sapiens (Human))
BDBM396288
PNG
(US10314832, Compound 11 | US10314832, Compound 4)
Show SMILES COCCOCOc1ccc(cc1)C(=O)CCC(=O)c1ccc2OCCOc2c1
Show InChI InChI=1S/C22H24O7/c1-25-10-11-26-15-29-18-5-2-16(3-6-18)19(23)7-8-20(24)17-4-9-21-22(14-17)28-13-12-27-21/h2-6,9,14H,7-8,10-13,15H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of ca...


US Patent US10314832 (2019)


BindingDB Entry DOI: 10.7270/Q2M047TC
More data for this
Ligand-Target Pair
Catenin beta-1


(Homo sapiens (Human))
BDBM396296
PNG
(US10314832, Compound 12)
Show SMILES COCCOCOc1cccc(c1)C(=O)CCC(=O)c1ccc2OCCOc2c1
Show InChI InChI=1S/C22H24O7/c1-25-9-10-26-15-29-18-4-2-3-16(13-18)19(23)6-7-20(24)17-5-8-21-22(14-17)28-12-11-27-21/h2-5,8,13-14H,6-7,9-12,15H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of ca...


US Patent US10314832 (2019)


BindingDB Entry DOI: 10.7270/Q2M047TC
More data for this
Ligand-Target Pair
Catenin beta-1


(Homo sapiens (Human))
BDBM396293
PNG
(US10314832, Compound 9)
Show SMILES CC(C)(CC(=O)c1ccccn1)C(=O)c1ccccc1
Show InChI InChI=1S/C17H17NO2/c1-17(2,16(20)13-8-4-3-5-9-13)12-15(19)14-10-6-7-11-18-14/h3-11H,12H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of ca...


US Patent US10314832 (2019)


BindingDB Entry DOI: 10.7270/Q2M047TC
More data for this
Ligand-Target Pair
Catenin beta-1


(Homo sapiens (Human))
BDBM396294
PNG
(US10314832, Compound 10)
Show SMILES COc1ccc(cc1)C(=O)CCC(=O)c1ccc2OCCOc2c1
Show InChI InChI=1S/C19H18O5/c1-22-15-5-2-13(3-6-15)16(20)7-8-17(21)14-4-9-18-19(12-14)24-11-10-23-18/h2-6,9,12H,7-8,10-11H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Samumed, LLC

US Patent


Assay Description
Compounds that enhance the Wnt activity, or Activators, were assayed as follows. Reporter cell lines were generated by stably transducing cells of ca...


US Patent US10314832 (2019)


BindingDB Entry DOI: 10.7270/Q2M047TC
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%