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Patent code US10322108

Compile Data Set for Download or QSAR
Found 46 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM397993
PNG
(US10322108, Example 1)
Show SMILES Cc1cccc2N(C(=O)\C(=C/c3c(Cl)cccc3C3CC3)c12)c1ccc(C(O)=O)c(O)c1
Show InChI InChI=1S/C26H20ClNO4/c1-14-4-2-7-22-24(14)20(13-19-17(15-8-9-15)5-3-6-21(19)27)25(30)28(22)16-10-11-18(26(31)32)23(29)12-16/h2-7,10-13,15,29H,8-9H2,1H3,(H,31,32)/b20-13-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398004
PNG
(US10322108, Example 8)
Show SMILES COc1cccc2N(C(=O)\C(=C/c3c(Cl)cccc3C3CC3)c12)c1ccc(C(O)=O)c(O)c1
Show InChI InChI=1S/C26H20ClNO5/c1-33-23-7-3-6-21-24(23)19(13-18-16(14-8-9-14)4-2-5-20(18)27)25(30)28(21)15-10-11-17(26(31)32)22(29)12-15/h2-7,10-14,29H,8-9H2,1H3,(H,31,32)/b19-13-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398001
PNG
(US10322108, Example 5)
Show SMILES Cc1cccc2N(C(=O)\C(=C/c3c(Cl)cccc3Cl)c12)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C23H15Cl2NO3/c1-13-4-2-7-20-21(13)17(12-16-18(24)5-3-6-19(16)25)22(27)26(20)15-10-8-14(9-11-15)23(28)29/h2-12H,1H3,(H,28,29)/b17-12-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398000
PNG
(US10322108, Example 4)
Show SMILES Cc1cccc2N(C(=O)\C(=C/c3c(Cl)cccc3Cl)c12)c1ccc(C(O)=O)c(O)c1
Show InChI InChI=1S/C23H15Cl2NO4/c1-12-4-2-7-19-21(12)16(11-15-17(24)5-3-6-18(15)25)22(28)26(19)13-8-9-14(23(29)30)20(27)10-13/h2-11,27H,1H3,(H,29,30)/b16-11-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398040
PNG
(US10322108, Example 36)
Show SMILES CC(C)c1cccc(Cl)c1\C=C1/C(=O)N(c2cccc(C)c12)c1ccc(C(O)=O)c(O)c1
Show InChI InChI=1S/C26H22ClNO4/c1-14(2)17-7-5-8-21(27)19(17)13-20-24-15(3)6-4-9-22(24)28(25(20)30)16-10-11-18(26(31)32)23(29)12-16/h4-14,29H,1-3H3,(H,31,32)/b20-13-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398027
PNG
(US10322108, Example 23)
Show SMILES OC(=O)c1ccc(cc1)N1C(=O)\C(=C/c2c(Cl)cccc2Cl)c2c1cccc2Cl
Show InChI InChI=1S/C22H12Cl3NO3/c23-16-3-1-4-17(24)14(16)11-15-20-18(25)5-2-6-19(20)26(21(15)27)13-9-7-12(8-10-13)22(28)29/h1-11H,(H,28,29)/b15-11-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398005
PNG
(US10322108, Example 9)
Show SMILES Cc1cccc2N(C(=O)\C(=C/c3c(F)cccc3Cl)c12)c1ccc(C(O)=O)c(O)c1
Show InChI InChI=1S/C23H15ClFNO4/c1-12-4-2-7-19-21(12)16(11-15-17(24)5-3-6-18(15)25)22(28)26(19)13-8-9-14(23(29)30)20(27)10-13/h2-11,27H,1H3,(H,29,30)/b16-11-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398041
PNG
(US10322108, Example 37)
Show SMILES CCc1cccc(Cl)c1\C=C1/C(=O)N(c2cccc(C)c12)c1ccc(C(O)=O)c(O)c1
Show InChI InChI=1S/C25H20ClNO4/c1-3-15-7-5-8-20(26)18(15)13-19-23-14(2)6-4-9-21(23)27(24(19)29)16-10-11-17(25(30)31)22(28)12-16/h4-13,28H,3H2,1-2H3,(H,30,31)/b19-13-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398014
PNG
(US10322108, Example 16B)
Show SMILES OC(=O)c1ccc(cc1)N1C(=O)\C(=C\c2c(Cl)cccc2C2CC2)c2c1cccc2F
Show InChI InChI=1S/C25H17ClFNO3/c26-20-4-1-3-17(14-7-8-14)18(20)13-19-23-21(27)5-2-6-22(23)28(24(19)29)16-11-9-15(10-12-16)25(30)31/h1-6,9-14H,7-8H2,(H,30,31)/b19-13+
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398012
PNG
(US10322108, Example 15B)
Show SMILES OC(=O)c1ccc(cc1)N1C(=O)\C(=C\c2c(Cl)cccc2Cl)c2c1cccc2F
Show InChI InChI=1S/C22H12Cl2FNO3/c23-16-3-1-4-17(24)14(16)11-15-20-18(25)5-2-6-19(20)26(21(15)27)13-9-7-12(8-10-13)22(28)29/h1-11H,(H,28,29)/b15-11+
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398034
PNG
(US10322108, Example 30)
Show SMILES COc1cccc2N(C(=O)\C(=C/c3c(Cl)cccc3C3CC3)c12)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C26H20ClNO4/c1-32-23-7-3-6-22-24(23)20(14-19-18(15-8-9-15)4-2-5-21(19)27)25(29)28(22)17-12-10-16(11-13-17)26(30)31/h2-7,10-15H,8-9H2,1H3,(H,30,31)/b20-14-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398026
PNG
(US10322108, Example 22B)
Show SMILES OC(=O)c1ccc(cc1O)N1C(=O)\C(=C\c2c(Cl)cccc2Cl)c2c1cccc2F
Show InChI InChI=1S/C22H12Cl2FNO4/c23-15-3-1-4-16(24)13(15)10-14-20-17(25)5-2-6-18(20)26(21(14)28)11-7-8-12(22(29)30)19(27)9-11/h1-10,27H,(H,29,30)/b14-10+
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398019
PNG
(US10322108, Example 19A)
Show SMILES OC(=O)c1ccc(cc1)N1C(=O)\C(=C/c2c(Cl)cccc2C(F)(F)F)c2c1cccc2F
Show InChI InChI=1S/C23H12ClF4NO3/c24-17-4-1-3-16(23(26,27)28)14(17)11-15-20-18(25)5-2-6-19(20)29(21(15)30)13-9-7-12(8-10-13)22(31)32/h1-11H,(H,31,32)/b15-11-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398011
PNG
(US10322108, Example 15A)
Show SMILES OC(=O)c1ccc(cc1)N1C(=O)\C(=C/c2c(Cl)cccc2Cl)c2c1cccc2F
Show InChI InChI=1S/C22H12Cl2FNO3/c23-16-3-1-4-17(24)14(16)11-15-20-18(25)5-2-6-19(20)26(21(15)27)13-9-7-12(8-10-13)22(28)29/h1-11H,(H,28,29)/b15-11-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398008
PNG
(US10322108, Example 12)
Show SMILES OC(=O)c1ccc(cc1O)N1C(=O)\C(=C/c2c(Cl)cccc2C2CC2)c2c1cccc2C1CC1
Show InChI InChI=1S/C28H22ClNO4/c29-23-5-1-3-18(15-7-8-15)21(23)14-22-26-19(16-9-10-16)4-2-6-24(26)30(27(22)32)17-11-12-20(28(33)34)25(31)13-17/h1-6,11-16,31H,7-10H2,(H,33,34)/b22-14-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398006
PNG
(US10322108, Example 10)
Show SMILES Cc1cccc2N(C(=O)\C(=C/c3c(C)cccc3Cl)c12)c1ccc(C(O)=O)c(O)c1
Show InChI InChI=1S/C24H18ClNO4/c1-13-5-3-7-19(25)17(13)12-18-22-14(2)6-4-8-20(22)26(23(18)28)15-9-10-16(24(29)30)21(27)11-15/h3-12,27H,1-2H3,(H,29,30)/b18-12-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398003
PNG
(US10322108, Example 7)
Show SMILES Cc1cccc2N(C(=O)\C(=C/c3c(Cl)cccc3Br)c12)c1ccc(C(O)=O)c(O)c1
Show InChI InChI=1S/C23H15BrClNO4/c1-12-4-2-7-19-21(12)16(11-15-17(24)5-3-6-18(15)25)22(28)26(19)13-8-9-14(23(29)30)20(27)10-13/h2-11,27H,1H3,(H,29,30)/b16-11-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM397999
PNG
(US10322108, Example 3)
Show SMILES COc1cccc(Cl)c1\C=C1/C(=O)N(c2cccc(C)c12)c1ccc(C(O)=O)c(O)c1
Show InChI InChI=1S/C24H18ClNO5/c1-13-5-3-7-19-22(13)17(12-16-18(25)6-4-8-21(16)31-2)23(28)26(19)14-9-10-15(24(29)30)20(27)11-14/h3-12,27H,1-2H3,(H,29,30)/b17-12-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM397995
PNG
(US10322108, Example 2A)
Show SMILES Cc1cccc2N(C(=O)\C(=C/c3c(Cl)cccc3C3CC3)c12)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C26H20ClNO3/c1-15-4-2-7-23-24(15)21(14-20-19(16-8-9-16)5-3-6-22(20)27)25(29)28(23)18-12-10-17(11-13-18)26(30)31/h2-7,10-14,16H,8-9H2,1H3,(H,30,31)/b21-14-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398002
PNG
(US10322108, Example 6)
Show SMILES Cc1cccc2N(C(=O)\C(=C/c3c(Cl)cccc3C(F)(F)F)c12)c1ccc(C(O)=O)c(O)c1
Show InChI InChI=1S/C24H15ClF3NO4/c1-12-4-2-7-19-21(12)16(11-15-17(24(26,27)28)5-3-6-18(15)25)22(31)29(19)13-8-9-14(23(32)33)20(30)10-13/h2-11,30H,1H3,(H,32,33)/b16-11-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398025
PNG
(US10322108, Example 22A)
Show SMILES OC(=O)c1ccc(cc1O)N1C(=O)\C(=C/c2c(Cl)cccc2Cl)c2c1cccc2F
Show InChI InChI=1S/C22H12Cl2FNO4/c23-15-3-1-4-16(24)13(15)10-14-20-17(25)5-2-6-18(20)26(21(14)28)11-7-8-12(22(29)30)19(27)9-11/h1-10,27H,(H,29,30)/b14-10-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398013
PNG
(US10322108, Example 16A)
Show SMILES OC(=O)c1ccc(cc1)N1C(=O)\C(=C/c2c(Cl)cccc2C2CC2)c2c1cccc2F
Show InChI InChI=1S/C25H17ClFNO3/c26-20-4-1-3-17(14-7-8-14)18(20)13-19-23-21(27)5-2-6-22(23)28(24(19)29)16-11-9-15(10-12-16)25(30)31/h1-6,9-14H,7-8H2,(H,30,31)/b19-13-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398020
PNG
(US10322108, Example 19B)
Show SMILES OC(=O)c1ccc(cc1)N1C(=O)\C(=C\c2c(Cl)cccc2C(F)(F)F)c2c1cccc2F
Show InChI InChI=1S/C23H12ClF4NO3/c24-17-4-1-3-16(23(26,27)28)14(17)11-15-20-18(25)5-2-6-19(20)29(21(15)30)13-9-7-12(8-10-13)22(31)32/h1-11H,(H,31,32)/b15-11+
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398023
PNG
(US10322108, Example 21A)
Show SMILES OC(=O)c1ccc(cc1O)N1C(=O)\C(=C/c2c(Cl)cccc2C2CC2)c2c1cccc2F
Show InChI InChI=1S/C25H17ClFNO4/c26-19-4-1-3-15(13-7-8-13)17(19)12-18-23-20(27)5-2-6-21(23)28(24(18)30)14-9-10-16(25(31)32)22(29)11-14/h1-6,9-13,29H,7-8H2,(H,31,32)/b18-12-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398038
PNG
(US10322108, Example 34)
Show SMILES Cc1cccc2N(C(=O)\C(=C/c3c(Cl)cccc3C3CCC3)c12)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C27H22ClNO3/c1-16-5-2-10-24-25(16)22(15-21-20(17-6-3-7-17)8-4-9-23(21)28)26(30)29(24)19-13-11-18(12-14-19)27(31)32/h2,4-5,8-15,17H,3,6-7H2,1H3,(H,31,32)/b22-15-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398033
PNG
(US10322108, Example 29)
Show SMILES Cc1cccc2N(C(=O)\C(=C/c3c(C)cccc3Cl)c12)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H18ClNO3/c1-14-5-3-7-20(25)18(14)13-19-22-15(2)6-4-8-21(22)26(23(19)27)17-11-9-16(10-12-17)24(28)29/h3-13H,1-2H3,(H,28,29)/b19-13-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398032
PNG
(US10322108, Example 28)
Show SMILES Cc1cccc2N(C(=O)\C(=C/c3c(Cl)cccc3C3CC3)c12)c1ccc(C(O)=O)c(OC(=O)C(C)(C)C)c1
Show InChI InChI=1S/C31H28ClNO5/c1-17-7-5-10-25-27(17)23(16-22-20(18-11-12-18)8-6-9-24(22)32)28(34)33(25)19-13-14-21(29(35)36)26(15-19)38-30(37)31(2,3)4/h5-10,13-16,18H,11-12H2,1-4H3,(H,35,36)/b23-16-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398010
PNG
(US10322108, Example 14)
Show SMILES OC(=O)c1ccc(cc1O)N1C(=O)\C(=C/c2c(Cl)cccc2C2CC2)c2c1cccc2Cl
Show InChI InChI=1S/C25H17Cl2NO4/c26-19-4-1-3-15(13-7-8-13)17(19)12-18-23-20(27)5-2-6-21(23)28(24(18)30)14-9-10-16(25(31)32)22(29)11-14/h1-6,9-13,29H,7-8H2,(H,31,32)/b18-12-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398016
PNG
(US10322108, Example 17B)
Show SMILES OC(=O)c1ccc(cc1)N1C(=O)\C(=C\c2c(F)cccc2Cl)c2c1cccc2F
Show InChI InChI=1S/C22H12ClF2NO3/c23-16-3-1-4-17(24)14(16)11-15-20-18(25)5-2-6-19(20)26(21(15)27)13-9-7-12(8-10-13)22(28)29/h1-11H,(H,28,29)/b15-11+
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM397996
PNG
(US10322108, Example 2B)
Show SMILES Cc1cccc2N(C(=O)\C(=C\c3c(Cl)cccc3C3CC3)c12)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C26H20ClNO3/c1-15-4-2-7-23-24(15)21(14-20-19(16-8-9-16)5-3-6-22(20)27)25(29)28(23)18-12-10-17(11-13-18)26(30)31/h2-7,10-14,16H,8-9H2,1H3,(H,30,31)/b21-14+
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398024
PNG
(US10322108, Example 21B)
Show SMILES OC(=O)c1ccc(cc1O)N1C(=O)\C(=C\c2c(Cl)cccc2C2CC2)c2c1cccc2F
Show InChI InChI=1S/C25H17ClFNO4/c26-19-4-1-3-15(13-7-8-13)17(19)12-18-23-20(27)5-2-6-21(23)28(24(18)30)14-9-10-16(25(31)32)22(29)11-14/h1-6,9-13,29H,7-8H2,(H,31,32)/b18-12+
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398021
PNG
(US10322108, Example 20A)
Show SMILES CCCc1cccc(Cl)c1\C=C1/C(=O)N(c2cccc(F)c12)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H19ClFNO3/c1-2-5-15-6-3-7-20(26)18(15)14-19-23-21(27)8-4-9-22(23)28(24(19)29)17-12-10-16(11-13-17)25(30)31/h3-4,6-14H,2,5H2,1H3,(H,30,31)/b19-14-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398015
PNG
(US10322108, Example 17A)
Show SMILES OC(=O)c1ccc(cc1)N1C(=O)\C(=C/c2c(F)cccc2Cl)c2c1cccc2F
Show InChI InChI=1S/C22H12ClF2NO3/c23-16-3-1-4-17(24)14(16)11-15-20-18(25)5-2-6-19(20)26(21(15)27)13-9-7-12(8-10-13)22(28)29/h1-11H,(H,28,29)/b15-11-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398029
PNG
(US10322108, Example 25)
Show SMILES Cc1cccc2N(C(=O)\C(=C/c3c(Cl)cccc3C3CC3)c12)c1ccc(C(O)=O)c(F)c1
Show InChI InChI=1S/C26H19ClFNO3/c1-14-4-2-7-23-24(14)20(13-19-17(15-8-9-15)5-3-6-21(19)27)25(30)29(23)16-10-11-18(26(31)32)22(28)12-16/h2-7,10-13,15H,8-9H2,1H3,(H,31,32)/b20-13-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398009
PNG
(US10322108, Example 13)
Show SMILES OC(=O)c1ccc(cc1)N1C(=O)\C(=C/c2c(Cl)cccc2C2CC2)c2c1cccc2-c1ccccc1
Show InChI InChI=1S/C31H22ClNO3/c32-27-10-4-8-23(20-12-13-20)25(27)18-26-29-24(19-6-2-1-3-7-19)9-5-11-28(29)33(30(26)34)22-16-14-21(15-17-22)31(35)36/h1-11,14-18,20H,12-13H2,(H,35,36)/b26-18-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398030
PNG
(US10322108, Example 26)
Show SMILES OC(=O)c1ccc(cc1O)N1C(=O)\C(=C/c2c(Cl)cccc2C2CC2)c2c1cccc2C(F)(F)F
Show InChI InChI=1S/C26H17ClF3NO4/c27-20-5-1-3-15(13-7-8-13)17(20)12-18-23-19(26(28,29)30)4-2-6-21(23)31(24(18)33)14-9-10-16(25(34)35)22(32)11-14/h1-6,9-13,32H,7-8H2,(H,34,35)/b18-12-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398007
PNG
(US10322108, Example 11)
Show SMILES COc1cccc2N(C(=O)\C(=C/c3c(Cl)cccc3Cl)c12)c1ccc(C(O)=O)c(O)c1
Show InChI InChI=1S/C23H15Cl2NO5/c1-31-20-7-3-6-18-21(20)15(11-14-16(24)4-2-5-17(14)25)22(28)26(18)12-8-9-13(23(29)30)19(27)10-12/h2-11,27H,1H3,(H,29,30)/b15-11-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398028
PNG
(US10322108, Example 24)
Show SMILES Cc1cccc2N(C(=O)\C(=C/c3c(Cl)cccc3C3CC3)c12)c1ccc(C(O)=O)c(Cl)c1
Show InChI InChI=1S/C26H19Cl2NO3/c1-14-4-2-7-23-24(14)20(13-19-17(15-8-9-15)5-3-6-21(19)27)25(30)29(23)16-10-11-18(26(31)32)22(28)12-16/h2-7,10-13,15H,8-9H2,1H3,(H,31,32)/b20-13-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398039
PNG
(US10322108, Example 35)
Show SMILES Cc1cccc2N(C(=O)\C(=C/c3c(Cl)cccc3C3CCC3)c12)c1ccc(C(O)=O)c(O)c1
Show InChI InChI=1S/C27H22ClNO4/c1-15-5-2-10-23-25(15)21(14-20-18(16-6-3-7-16)8-4-9-22(20)28)26(31)29(23)17-11-12-19(27(32)33)24(30)13-17/h2,4-5,8-14,16,30H,3,6-7H2,1H3,(H,32,33)/b21-14-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398022
PNG
(US10322108, Example 20B)
Show SMILES CCCc1cccc(Cl)c1\C=C1\C(=O)N(c2cccc(F)c12)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H19ClFNO3/c1-2-5-15-6-3-7-20(26)18(15)14-19-23-21(27)8-4-9-22(23)28(24(19)29)17-12-10-16(11-13-17)25(30)31/h3-4,6-14H,2,5H2,1H3,(H,30,31)/b19-14+
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398031
PNG
(US10322108, Example 27)
Show SMILES OC(=O)c1ccc(cc1O)N1C(=O)\C(=C/c2c(Cl)cccc2C2CC2)c2ccccc12
Show InChI InChI=1S/C25H18ClNO4/c26-21-6-3-5-16(14-8-9-14)19(21)13-20-17-4-1-2-7-22(17)27(24(20)29)15-10-11-18(25(30)31)23(28)12-15/h1-7,10-14,28H,8-9H2,(H,30,31)/b20-13-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398018
PNG
(US10322108, Example 18B)
Show SMILES OC(=O)c1ccc(cc1)N1C(=O)\C(=C\c2c(F)cccc2F)c2c1cccc2F
Show InChI InChI=1S/C22H12F3NO3/c23-16-3-1-4-17(24)14(16)11-15-20-18(25)5-2-6-19(20)26(21(15)27)13-9-7-12(8-10-13)22(28)29/h1-11H,(H,28,29)/b15-11+
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398036
PNG
(US10322108, Example 32)
Show SMILES COc1cccc(Cl)c1\C=C1/C(=O)N(c2cccc(C)c12)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H18ClNO4/c1-14-5-3-7-20-22(14)18(13-17-19(25)6-4-8-21(17)30-2)23(27)26(20)16-11-9-15(10-12-16)24(28)29/h3-13H,1-2H3,(H,28,29)/b18-13-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398037
PNG
(US10322108, Example 33)
Show SMILES Cc1cccc2N(C(=O)\C(=C/c3c(Cl)cccc3C3CC3)c12)c1ccc(C(O)=O)c(N)c1
Show InChI InChI=1S/C26H21ClN2O3/c1-14-4-2-7-23-24(14)20(13-19-17(15-8-9-15)5-3-6-21(19)27)25(30)29(23)16-10-11-18(26(31)32)22(28)12-16/h2-7,10-13,15H,8-9,28H2,1H3,(H,31,32)/b20-13-
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Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398035
PNG
(US10322108, Example 31)
Show SMILES COc1cccc2N(C(=O)\C(=C/c3c(Cl)cccc3Cl)c12)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C23H15Cl2NO4/c1-30-20-7-3-6-19-21(20)16(12-15-17(24)4-2-5-18(15)25)22(27)26(19)14-10-8-13(9-11-14)23(28)29/h2-12H,1H3,(H,28,29)/b16-12-
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM398017
PNG
(US10322108, Example 18A)
Show SMILES OC(=O)c1ccc(cc1)N1C(=O)\C(=C/c2c(F)cccc2F)c2c1cccc2F
Show InChI InChI=1S/C22H12F3NO3/c23-16-3-1-4-17(24)14(16)11-15-20-18(25)5-2-6-19(20)26(21(15)27)13-9-7-12(8-10-13)22(28)29/h1-11H,(H,28,29)/b15-11-
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Beijing Hanmi Pharmaceutical Co., Ltd.

US Patent


Assay Description
The compounds of the present application can regulate (inhibit) the biological activity of the nuclear receptor RORγ, and the intensity of such ...


US Patent US10322108 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%