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Patent code US10323018

Compile Data Set for Download or QSAR

Found 229 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398264
PNG
(US10323018, Compound I-1)
Show SMILES CCCc1nc(nc2cc(ccc12)C(=O)NCCc1cncn1C)-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H24ClN5O/c1-3-4-21-20-10-7-17(24(31)27-12-11-19-14-26-15-30(19)2)13-22(20)29-23(28-21)16-5-8-18(25)9-6-16/h5-10,13-15H,3-4,11-12H2,1-2H3,(H,27,31)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398278
PNG
(US10323018, Compound I-12)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCCCc1ncc[nH]1)-c1cc(OC)ncc1F
Show InChI InChI=1S/C24H24FN5O3/c1-3-33-21-13-20(17-12-23(32-2)29-14-18(17)25)30-19-11-15(6-7-16(19)21)24(31)28-8-4-5-22-26-9-10-27-22/h6-7,9-14H,3-5,8H2,1-2H3,(H,26,27)(H,28,31)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398295
PNG
(US10323018, Compound I-24)
Show SMILES CCCc1nc(nc2cc(ccc12)C(=O)NCCCc1ncc[nH]1)-c1ccc(Cl)s1
Show InChI InChI=1S/C22H22ClN5OS/c1-2-4-16-15-7-6-14(22(29)26-10-3-5-20-24-11-12-25-20)13-17(15)28-21(27-16)18-8-9-19(23)30-18/h6-9,11-13H,2-5,10H2,1H3,(H,24,25)(H,26,29)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398306
PNG
(US10323018, Compound I-35)
Show SMILES CCOc1nc(nc2cc(ccc12)C(=O)NCCCc1ncc[nH]1)-c1ccc(Cl)s1
Show InChI InChI=1S/C21H20ClN5O2S/c1-2-29-21-14-6-5-13(20(28)25-9-3-4-18-23-10-11-24-18)12-15(14)26-19(27-21)16-7-8-17(22)30-16/h5-8,10-12H,2-4,9H2,1H3,(H,23,24)(H,25,28)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398366
PNG
(US10323018, Compound I-95)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCCCc1cnn[nH]1)-c1ccn(C)c(=O)c1
Show InChI InChI=1S/C23H24N6O3/c1-3-32-21-13-19(15-8-10-29(2)22(30)12-15)26-20-11-16(6-7-18(20)21)23(31)24-9-4-5-17-14-25-28-27-17/h6-8,10-14H,3-5,9H2,1-2H3,(H,24,31)(H,25,27,28)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398370
PNG
(US10323018, Compound I-99)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCc1nc2cnccc2[nH]1)-c1ccnc(C)c1
Show InChI InChI=1S/C25H22N6O2/c1-3-33-23-12-20(16-6-9-27-15(2)10-16)29-21-11-17(4-5-18(21)23)25(32)28-14-24-30-19-7-8-26-13-22(19)31-24/h4-13H,3,14H2,1-2H3,(H,28,32)(H,30,31)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398378
PNG
(US10323018, Compound I-107)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCCc1cnn[nH]1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H20FN5O2/c1-2-30-21-12-19(14-3-6-16(23)7-4-14)26-20-11-15(5-8-18(20)21)22(29)24-10-9-17-13-25-28-27-17/h3-8,11-13H,2,9-10H2,1H3,(H,24,29)(H,25,27,28)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398438
PNG
(US10323018, Compound I-167)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCc1nc2cnccc2[nH]1)-c1ccc(C)nc1
Show InChI InChI=1S/C25H22N6O2/c1-3-33-23-11-20(17-5-4-15(2)27-12-17)29-21-10-16(6-7-18(21)23)25(32)28-14-24-30-19-8-9-26-13-22(19)31-24/h4-13H,3,14H2,1-2H3,(H,28,32)(H,30,31)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398446
PNG
(US10323018, Compound I-175)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCc1nc2cnccc2[nH]1)-c1ccc(Cl)s1
Show InChI InChI=1S/C23H18ClN5O2S/c1-2-31-19-10-17(20-5-6-21(24)32-20)27-16-9-13(3-4-14(16)19)23(30)26-12-22-28-15-7-8-25-11-18(15)29-22/h3-11H,2,12H2,1H3,(H,26,30)(H,28,29)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398279
PNG
(US10323018, Compound I-13)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCCCc1ncc[nH]1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H23ClN4O2/c1-2-31-22-15-20(16-5-8-18(25)9-6-16)29-21-14-17(7-10-19(21)22)24(30)28-11-3-4-23-26-12-13-27-23/h5-10,12-15H,2-4,11H2,1H3,(H,26,27)(H,28,30)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398281
PNG
(US10323018, Compound I-15)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCCCc1ncc[nH]1)-c1ccc(F)cc1
Show InChI InChI=1S/C24H23FN4O2/c1-2-31-22-15-20(16-5-8-18(25)9-6-16)29-21-14-17(7-10-19(21)22)24(30)28-11-3-4-23-26-12-13-27-23/h5-10,12-15H,2-4,11H2,1H3,(H,26,27)(H,28,30)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398290
PNG
(US10323018, Compound I-19)
Show SMILES CCOc1nc(nc2cc(ccc12)C(=O)NCCCc1cncnc1)-c1ccc(F)cc1
Show InChI InChI=1S/C24H22FN5O2/c1-2-32-24-20-10-7-18(23(31)28-11-3-4-16-13-26-15-27-14-16)12-21(20)29-22(30-24)17-5-8-19(25)9-6-17/h5-10,12-15H,2-4,11H2,1H3,(H,28,31)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398311
PNG
(US10323018, Compound I-40)
Show SMILES Fc1ccc(cc1)-c1nc(OCC2CC2)c2ccc(cc2n1)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C25H24FN5O2/c26-19-8-5-17(6-9-19)23-30-21-14-18(24(32)29-11-1-2-22-27-12-13-28-22)7-10-20(21)25(31-23)33-15-16-3-4-16/h5-10,12-14,16H,1-4,11,15H2,(H,27,28)(H,29,32)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398343
PNG
(US10323018, Compound I-72)
Show SMILES CC[C@@H](F)c1nc(nc2cc(ccc12)C(=O)NCCCc1ncc[nH]1)-c1ccc(Cl)cc1
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398355
PNG
(US10323018, Compound I-84)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCc1ccc2ncnn2c1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H20FN5O2/c1-2-33-23-12-21(17-4-7-19(26)8-5-17)30-22-11-18(6-9-20(22)23)25(32)27-13-16-3-10-24-28-15-29-31(24)14-16/h3-12,14-15H,2,13H2,1H3,(H,27,32)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398401
PNG
(US10323018, Compound I-130)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCc1ccn2ncnc2c1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H20FN5O2/c1-2-33-23-13-21(17-3-6-19(26)7-4-17)30-22-12-18(5-8-20(22)23)25(32)27-14-16-9-10-31-24(11-16)28-15-29-31/h3-13,15H,2,14H2,1H3,(H,27,32)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398464
PNG
(US10323018, Compound I-193)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCc1nc2cnccc2[nH]1)-c1ccc(OC)nc1
Show InChI InChI=1S/C25H22N6O3/c1-3-34-22-11-19(16-5-7-24(33-2)27-12-16)29-20-10-15(4-6-17(20)22)25(32)28-14-23-30-18-8-9-26-13-21(18)31-23/h4-13H,3,14H2,1-2H3,(H,28,32)(H,30,31)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398467
PNG
(US10323018, Compound I-196)
Show SMILES COc1cc(ccn1)-c1nc(nc2cc(ccc12)C(=O)NCCCc1ncc[nH]1)-c1ccc(F)cc1
Show InChI InChI=1S/C27H23FN6O2/c1-36-24-16-18(10-12-31-24)25-21-9-6-19(27(35)32-11-2-3-23-29-13-14-30-23)15-22(21)33-26(34-25)17-4-7-20(28)8-5-17/h4-10,12-16H,2-3,11H2,1H3,(H,29,30)(H,32,35)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398469
PNG
(US10323018, Compound I-198)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCCCc1nnc[nH]1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H22ClN5O2/c1-2-31-21-13-19(15-5-8-17(24)9-6-15)28-20-12-16(7-10-18(20)21)23(30)25-11-3-4-22-26-14-27-29-22/h5-10,12-14H,2-4,11H2,1H3,(H,25,30)(H,26,27,29)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398495
PNG
(US10323018, Compound I-224)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCCCc1cncn1C)-c1ccc(F)cc1
Show InChI InChI=1S/C25H25FN4O2/c1-3-32-24-14-22(17-6-9-19(26)10-7-17)29-23-13-18(8-11-21(23)24)25(31)28-12-4-5-20-15-27-16-30(20)2/h6-11,13-16H,3-5,12H2,1-2H3,(H,28,31)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398498
PNG
(US10323018, Compound I-227)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCCCc1ccc(C)nc1)-c1ccc(F)cc1
Show InChI InChI=1S/C27H26FN3O2/c1-3-33-26-16-24(20-8-11-22(28)12-9-20)31-25-15-21(10-13-23(25)26)27(32)29-14-4-5-19-7-6-18(2)30-17-19/h6-13,15-17H,3-5,14H2,1-2H3,(H,29,32)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398299
PNG
(US10323018, Compound I-28)
Show SMILES CCOc1nc(nc2cc(ccc12)C(=O)NCc1ccc2nccn2c1)-c1ccc(Cl)s1
Show InChI InChI=1S/C23H18ClN5O2S/c1-2-31-23-16-5-4-15(11-17(16)27-21(28-23)18-6-7-19(24)32-18)22(30)26-12-14-3-8-20-25-9-10-29(20)13-14/h3-11,13H,2,12H2,1H3,(H,26,30)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398321
PNG
(US10323018, Compound I-50 | US10323018, Compound I...)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCC1CC1c1ncc[nH]1)-c1ccc(F)cc1
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398331
PNG
(US10323018, Compound I-60)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NC1CC(C1)c1ncc[nH]1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H23FN4O2/c1-2-32-23-14-21(15-3-6-18(26)7-4-15)30-22-13-16(5-8-20(22)23)25(31)29-19-11-17(12-19)24-27-9-10-28-24/h3-10,13-14,17,19H,2,11-12H2,1H3,(H,27,28)(H,29,31)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398344
PNG
(US10323018, Compound I-73)
Show SMILES CCOc1c(F)c(nc2cc(ccc12)C(=O)NCCCc1cnn[nH]1)-c1ccc(F)cc1
Show InChI InChI=1S/C23H21F2N5O2/c1-2-32-22-18-10-7-15(23(31)26-11-3-4-17-13-27-30-29-17)12-19(18)28-21(20(22)25)14-5-8-16(24)9-6-14/h5-10,12-13H,2-4,11H2,1H3,(H,26,31)(H,27,29,30)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398381
PNG
(US10323018, Compound I-110)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCCCc1cnn[nH]1)-c1ccc(C)nc1
Show InChI InChI=1S/C23H24N6O2/c1-3-31-22-12-20(17-7-6-15(2)25-13-17)27-21-11-16(8-9-19(21)22)23(30)24-10-4-5-18-14-26-29-28-18/h6-9,11-14H,3-5,10H2,1-2H3,(H,24,30)(H,26,28,29)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398449
PNG
(US10323018, Compound I-178)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCc1nc2cnccc2n1C)-c1ccc(F)cc1
Show InChI InChI=1S/C26H22FN5O2/c1-3-34-24-13-20(16-4-7-18(27)8-5-16)30-21-12-17(6-9-19(21)24)26(33)29-15-25-31-22-14-28-11-10-23(22)32(25)2/h4-14H,3,15H2,1-2H3,(H,29,33)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398465
PNG
(US10323018, Compound I-194)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCc1nc2cnccc2[nH]1)-c1ccnc(OC)c1
Show InChI InChI=1S/C25H22N6O3/c1-3-34-22-12-19(15-6-9-27-24(11-15)33-2)29-20-10-16(4-5-17(20)22)25(32)28-14-23-30-18-7-8-26-13-21(18)31-23/h4-13H,3,14H2,1-2H3,(H,28,32)(H,30,31)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398275
PNG
(US10323018, Compound I-9)
Show SMILES CCCc1nc(nc2cc(ccc12)C(=O)NCc1nc2ccncc2[nH]1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H21ClN6O/c1-2-3-19-18-9-6-16(12-21(18)32-24(31-19)15-4-7-17(26)8-5-15)25(33)28-14-23-29-20-10-11-27-13-22(20)30-23/h4-13H,2-3,14H2,1H3,(H,28,33)(H,29,30)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398276
PNG
(US10323018, Compound I-10)
Show SMILES COc1nc(nc2cc(ccc12)C(=O)NCCCc1ncc[nH]1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H20ClN5O2/c1-30-22-17-9-6-15(21(29)26-10-2-3-19-24-11-12-25-19)13-18(17)27-20(28-22)14-4-7-16(23)8-5-14/h4-9,11-13H,2-3,10H2,1H3,(H,24,25)(H,26,29)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398303
PNG
(US10323018, Compound I-32)
Show SMILES CCOc1nc(nc2cc(ccc12)C(=O)NCCCc1ncc[nH]1)-c1ccc(F)cc1
Show InChI InChI=1S/C23H22FN5O2/c1-2-31-23-18-10-7-16(22(30)27-11-3-4-20-25-12-13-26-20)14-19(18)28-21(29-23)15-5-8-17(24)9-6-15/h5-10,12-14H,2-4,11H2,1H3,(H,25,26)(H,27,30)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398307
PNG
(US10323018, Compound I-36)
Show SMILES CC(C)Oc1nc(nc2cc(ccc12)C(=O)NCCCc1ncc[nH]1)-c1ccc(F)cc1
Show InChI InChI=1S/C24H24FN5O2/c1-15(2)32-24-19-10-7-17(23(31)28-11-3-4-21-26-12-13-27-21)14-20(19)29-22(30-24)16-5-8-18(25)9-6-16/h5-10,12-15H,3-4,11H2,1-2H3,(H,26,27)(H,28,31)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398314
PNG
(US10323018, Compound I-43)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCCCn1cccn1)-c1ccc(F)cc1
Show InChI InChI=1S/C24H23FN4O2/c1-2-31-23-16-21(17-5-8-19(25)9-6-17)28-22-15-18(7-10-20(22)23)24(30)26-11-3-13-29-14-4-12-27-29/h4-10,12,14-16H,2-3,11,13H2,1H3,(H,26,30)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398325
PNG
(US10323018, Compound I-54)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCc1nc2ccccc2[nH]1)-c1ccc(F)cc1
Show InChI InChI=1S/C26H21FN4O2/c1-2-33-24-14-22(16-7-10-18(27)11-8-16)29-23-13-17(9-12-19(23)24)26(32)28-15-25-30-20-5-3-4-6-21(20)31-25/h3-14H,2,15H2,1H3,(H,28,32)(H,30,31)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398341
PNG
(US10323018, Compound I-70)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCc1ccn2ncnc2c1)-c1ccnc(OC)c1
Show InChI InChI=1S/C25H22N6O3/c1-3-34-22-13-20(17-6-8-26-24(12-17)33-2)30-21-11-18(4-5-19(21)22)25(32)27-14-16-7-9-31-23(10-16)28-15-29-31/h4-13,15H,3,14H2,1-2H3,(H,27,32)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398356
PNG
(US10323018, Compound I-85)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCc1ccn2ncnc2c1)-c1ccc(F)cc1OC
Show InChI InChI=1S/C26H22FN5O3/c1-3-35-24-13-22(19-7-5-18(27)12-23(19)34-2)31-21-11-17(4-6-20(21)24)26(33)28-14-16-8-9-32-25(10-16)29-15-30-32/h4-13,15H,3,14H2,1-2H3,(H,28,33)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398386
PNG
(US10323018, Compound I-115)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCCCc1cnn[nH]1)-c1ccc(F)cc1
Show InChI InChI=1S/C23H22FN5O2/c1-2-31-22-13-20(15-5-8-17(24)9-6-15)27-21-12-16(7-10-19(21)22)23(30)25-11-3-4-18-14-26-29-28-18/h5-10,12-14H,2-4,11H2,1H3,(H,25,30)(H,26,28,29)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398396
PNG
(US10323018, Compound I-125)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCCCc1nnc[nH]1)-c1ccc(Cl)s1
Show InChI InChI=1S/C21H20ClN5O2S/c1-2-29-17-11-16(18-7-8-19(22)30-18)26-15-10-13(5-6-14(15)17)21(28)23-9-3-4-20-24-12-25-27-20/h5-8,10-12H,2-4,9H2,1H3,(H,23,28)(H,24,25,27)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398404
PNG
(US10323018, Compound I-133)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCCCc1n[nH]nc1C)-c1ccc(F)cc1
Show InChI InChI=1S/C24H24FN5O2/c1-3-32-23-14-21(16-6-9-18(25)10-7-16)27-22-13-17(8-11-19(22)23)24(31)26-12-4-5-20-15(2)28-30-29-20/h6-11,13-14H,3-5,12H2,1-2H3,(H,26,31)(H,28,29,30)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398475
PNG
(US10323018, Compound I-204)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCCCc1cc[nH]n1)-c1ccc(F)cc1
Show InChI InChI=1S/C24H23FN4O2/c1-2-31-23-15-21(16-5-8-18(25)9-6-16)28-22-14-17(7-10-20(22)23)24(30)26-12-3-4-19-11-13-27-29-19/h5-11,13-15H,2-4,12H2,1H3,(H,26,30)(H,27,29)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398357
PNG
(US10323018, Compound I-86)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCc1ccn2ncnc2c1)-c1ccnc(C)c1
Show InChI InChI=1S/C25H22N6O2/c1-3-33-23-13-21(18-6-8-26-16(2)10-18)30-22-12-19(4-5-20(22)23)25(32)27-14-17-7-9-31-24(11-17)28-15-29-31/h4-13,15H,3,14H2,1-2H3,(H,27,32)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398407
PNG
(US10323018, Compound I-136)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCCCc1nnc[nH]1)-c1cc(C)nc(OC)c1
Show InChI InChI=1S/C24H26N6O3/c1-4-33-21-13-19(17-10-15(2)28-23(12-17)32-3)29-20-11-16(7-8-18(20)21)24(31)25-9-5-6-22-26-14-27-30-22/h7-8,10-14H,4-6,9H2,1-3H3,(H,25,31)(H,26,27,30)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398419
PNG
(US10323018, Compound I-148)
Show SMILES Fc1ccc(cc1)-c1cc(-n2ccnc2)c2ccc(cc2n1)C(=O)NCCCc1nnc[nH]1
Show InChI InChI=1S/C24H20FN7O/c25-18-6-3-16(4-7-18)20-13-22(32-11-10-26-15-32)19-8-5-17(12-21(19)30-20)24(33)27-9-1-2-23-28-14-29-31-23/h3-8,10-15H,1-2,9H2,(H,27,33)(H,28,29,31)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398435
PNG
(US10323018, Compound I-164)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCCCc1nnc[nH]1)-c1cc(OC)ncc1Cl
Show InChI InChI=1S/C23H23ClN6O3/c1-3-33-20-11-19(16-10-22(32-2)26-12-17(16)24)29-18-9-14(6-7-15(18)20)23(31)25-8-4-5-21-27-13-28-30-21/h6-7,9-13H,3-5,8H2,1-2H3,(H,25,31)(H,27,28,30)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398458
PNG
(US10323018, Compound I-187)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCc1nc2cnccc2[nH]1)-c1cc(F)ccc1OC
Show InChI InChI=1S/C26H22FN5O3/c1-3-35-24-12-21(18-11-16(27)5-7-23(18)34-2)30-20-10-15(4-6-17(20)24)26(33)29-14-25-31-19-8-9-28-13-22(19)32-25/h4-13H,3,14H2,1-2H3,(H,29,33)(H,31,32)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398463
PNG
(US10323018, Compound I-192)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCc1nc2ccncc2[nH]1)-c1cccnc1OC
Show InChI InChI=1S/C25H22N6O3/c1-3-34-22-12-20(17-5-4-9-27-25(17)33-2)29-19-11-15(6-7-16(19)22)24(32)28-14-23-30-18-8-10-26-13-21(18)31-23/h4-13H,3,14H2,1-2H3,(H,28,32)(H,30,31)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398499
PNG
(US10323018, Compound I-228)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCCCc1cncnc1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H23FN4O2/c1-2-32-24-13-22(18-5-8-20(26)9-6-18)30-23-12-19(7-10-21(23)24)25(31)29-11-3-4-17-14-27-16-28-15-17/h5-10,12-16H,2-4,11H2,1H3,(H,29,31)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398267
PNG
(US10323018, Compound I-4)
Show SMILES CCCc1nc(nc2cc(ccc12)C(=O)NCCCc1ncc[nH]1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H24ClN5O/c1-2-4-20-19-11-8-17(24(31)28-12-3-5-22-26-13-14-27-22)15-21(19)30-23(29-20)16-6-9-18(25)10-7-16/h6-11,13-15H,2-5,12H2,1H3,(H,26,27)(H,28,31)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398280
PNG
(US10323018, Compound I-14)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCc1nc2cnccc2[nH]1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H20FN5O2/c1-2-33-23-12-20(15-3-6-17(26)7-4-15)29-21-11-16(5-8-18(21)23)25(32)28-14-24-30-19-9-10-27-13-22(19)31-24/h3-13H,2,14H2,1H3,(H,28,32)(H,30,31)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398282
PNG
(US10323018, Compound I-16)
Show SMILES CCCc1nc(nc2cc(ccc12)C(=O)NCCCc1ncc[nH]1)-c1ccc(F)cc1
Show InChI InChI=1S/C24H24FN5O/c1-2-4-20-19-11-8-17(24(31)28-12-3-5-22-26-13-14-27-22)15-21(19)30-23(29-20)16-6-9-18(25)10-7-16/h6-11,13-15H,2-5,12H2,1H3,(H,26,27)(H,28,31)
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Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10323018 (2019)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%