BindingDB logo
myBDB logout

Patent code US10323019

Compile Data Set for Download or QSAR
Found 18 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM398506
PNG
((2R)-1,1,1-Trifluoro-3-({cis-4-[(1-methyl-4-{[1-(p...)
Show SMILES Cn1cnc2c(Nc3ccn(n3)-c3ccccn3)cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)(F)F)cc12
Show InChI InChI=1S/C25H28F3N7O2/c1-34-15-31-24-19(32-22-9-11-35(33-22)23-4-2-3-10-29-23)12-18(13-20(24)34)37-17-7-5-16(6-8-17)30-14-21(36)25(26,27)28/h2-4,9-13,15-17,21,30,36H,5-8,14H2,1H3,(H,32,33)/t16-,17+,21-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.49n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...

US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM398504
PNG
((2R)-1,1,1-Trifluoro-3-[(cis-1-methyl-4-{[1-methyl...)
Show SMILES Cn1cnc2c(Nc3cc[nH]n3)cc(O[C@H]3CCC(C)(CC3)NC[C@@H](O)C(F)(F)F)cc12
Show InChI InChI=1/C21H27F3N6O2/c1-20(26-11-17(31)21(22,23)24)6-3-13(4-7-20)32-14-9-15(28-18-5-8-27-29-18)19-16(10-14)30(2)12-25-19/h5,8-10,12-13,17,26,31H,3-4,6-7,11H2,1-2H3,(H2,27,28,29)/t13-,17-,20?/s2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.91n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...

US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM398501
PNG
((2R)-1,1,1-Trifluoro-3-({cis-4-[(4-{[1-(3-methoxyp...)
Show SMILES COCCCn1nc(Nc2cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)(F)F)cc3n(C)cnc23)cc1C
Show InChI InChI=1S/C25H35F3N6O3/c1-16-11-23(32-34(16)9-4-10-36-3)31-20-12-19(13-21-24(20)30-15-33(21)2)37-18-7-5-17(6-8-18)29-14-22(35)25(26,27)28/h11-13,15,17-18,22,29,35H,4-10,14H2,1-3H3,(H,31,32)/t17-,18+,22-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.25n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...

US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM398502
PNG
((2R)-1,1,1-Trifluoro-3-{[cis-4-({4-[(5-methoxy-1-m...)
Show SMILES COc1cc(Nc2cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)(F)F)cc3n(C)cnc23)nn1C
Show InChI InChI=1S/C22H29F3N6O3/c1-30-12-27-21-16(28-19-10-20(33-3)31(2)29-19)8-15(9-17(21)30)34-14-6-4-13(5-7-14)26-11-18(32)22(23,24)25/h8-10,12-14,18,26,32H,4-7,11H2,1-3H3,(H,28,29)/t13-,14+,18-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.25n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...

US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM398505
PNG
((2R)-3-{[cis-4-({4-[(1,5-Dimethyl-1H-pyrazol-3-yl)...)
Show SMILES Cc1cc(Nc2cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)F)cc3n(C)cnc23)nn1C
Show InChI InChI=1S/C22H30F2N6O2/c1-13-8-20(28-30(13)3)27-17-9-16(10-18-21(17)26-12-29(18)2)32-15-6-4-14(5-7-15)25-11-19(31)22(23)24/h8-10,12,14-15,19,22,25,31H,4-7,11H2,1-3H3,(H,27,28)/t14-,15+,19-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.35n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...

US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM398503
PNG
((2R)-3-{[(cis-4-({4-[(Ethyl-5-methyl-1H-pyrazol-3-...)
Show SMILES CCn1nc(Nc2cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)(F)F)cc3n(C)cnc23)cc1C
Show InChI InChI=1S/C23H31F3N6O2/c1-4-32-14(2)9-21(30-32)29-18-10-17(11-19-22(18)28-13-31(19)3)34-16-7-5-15(6-8-16)27-12-20(33)23(24,25)26/h9-11,13,15-16,20,27,33H,4-8,12H2,1-3H3,(H,29,30)/t15-,16+,20-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.43n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...

US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM398506
PNG
((2R)-1,1,1-Trifluoro-3-({cis-4-[(1-methyl-4-{[1-(p...)
Show SMILES Cn1cnc2c(Nc3ccn(n3)-c3ccccn3)cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)(F)F)cc12
Show InChI InChI=1S/C25H28F3N7O2/c1-34-15-31-24-19(32-22-9-11-35(33-22)23-4-2-3-10-29-23)12-18(13-20(24)34)37-17-7-5-16(6-8-17)30-14-21(36)25(26,27)28/h2-4,9-13,15-17,21,30,36H,5-8,14H2,1H3,(H,32,33)/t16-,17+,21-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 220n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...

US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM398504
PNG
((2R)-1,1,1-Trifluoro-3-[(cis-1-methyl-4-{[1-methyl...)
Show SMILES Cn1cnc2c(Nc3cc[nH]n3)cc(O[C@H]3CCC(C)(CC3)NC[C@@H](O)C(F)(F)F)cc12
Show InChI InChI=1/C21H27F3N6O2/c1-20(26-11-17(31)21(22,23)24)6-3-13(4-7-20)32-14-9-15(28-18-5-8-27-29-18)19-16(10-14)30(2)12-25-19/h5,8-10,12-13,17,26,31H,3-4,6-7,11H2,1-2H3,(H2,27,28,29)/t13-,17-,20?/s2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 239n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...

US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
JAK3/JAK1


(Homo sapiens (Human))		BDBM398506
PNG
((2R)-1,1,1-Trifluoro-3-({cis-4-[(1-methyl-4-{[1-(p...)
Show SMILES Cn1cnc2c(Nc3ccn(n3)-c3ccccn3)cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)(F)F)cc12
Show InChI InChI=1S/C25H28F3N7O2/c1-34-15-31-24-19(32-22-9-11-35(33-22)23-4-2-3-10-29-23)12-18(13-20(24)34)37-17-7-5-16(6-8-17)30-14-21(36)25(26,27)28/h2-4,9-13,15-17,21,30,36H,5-8,14H2,1H3,(H,32,33)/t16-,17+,21-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 660n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...

US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM398505
PNG
((2R)-3-{[cis-4-({4-[(1,5-Dimethyl-1H-pyrazol-3-yl)...)
Show SMILES Cc1cc(Nc2cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)F)cc3n(C)cnc23)nn1C
Show InChI InChI=1S/C22H30F2N6O2/c1-13-8-20(28-30(13)3)27-17-9-16(10-18-21(17)26-12-29(18)2)32-15-6-4-14(5-7-15)25-11-19(31)22(23)24/h8-10,12,14-15,19,22,25,31H,4-7,11H2,1-3H3,(H,27,28)/t14-,15+,19-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 767n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...

US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM398502
PNG
((2R)-1,1,1-Trifluoro-3-{[cis-4-({4-[(5-methoxy-1-m...)
Show SMILES COc1cc(Nc2cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)(F)F)cc3n(C)cnc23)nn1C
Show InChI InChI=1S/C22H29F3N6O3/c1-30-12-27-21-16(28-19-10-20(33-3)31(2)29-19)8-15(9-17(21)30)34-14-6-4-13(5-7-14)26-11-18(32)22(23,24)25/h8-10,12-14,18,26,32H,4-7,11H2,1-3H3,(H,28,29)/t13-,14+,18-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 768n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...

US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM398503
PNG
((2R)-3-{[(cis-4-({4-[(Ethyl-5-methyl-1H-pyrazol-3-...)
Show SMILES CCn1nc(Nc2cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)(F)F)cc3n(C)cnc23)cc1C
Show InChI InChI=1S/C23H31F3N6O2/c1-4-32-14(2)9-21(30-32)29-18-10-17(11-19-22(18)28-13-31(19)3)34-16-7-5-15(6-8-16)27-12-20(33)23(24,25)26/h9-11,13,15-16,20,27,33H,4-8,12H2,1-3H3,(H,29,30)/t15-,16+,20-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 901n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...

US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
JAK3/JAK1


(Homo sapiens (Human))		BDBM398504
PNG
((2R)-1,1,1-Trifluoro-3-[(cis-1-methyl-4-{[1-methyl...)
Show SMILES Cn1cnc2c(Nc3cc[nH]n3)cc(O[C@H]3CCC(C)(CC3)NC[C@@H](O)C(F)(F)F)cc12
Show InChI InChI=1/C21H27F3N6O2/c1-20(26-11-17(31)21(22,23)24)6-3-13(4-7-20)32-14-9-15(28-18-5-8-27-29-18)19-16(10-14)30(2)12-25-19/h5,8-10,12-13,17,26,31H,3-4,6-7,11H2,1-2H3,(H2,27,28,29)/t13-,17-,20?/s2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.17E+3n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...

US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM398501
PNG
((2R)-1,1,1-Trifluoro-3-({cis-4-[(4-{[1-(3-methoxyp...)
Show SMILES COCCCn1nc(Nc2cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)(F)F)cc3n(C)cnc23)cc1C
Show InChI InChI=1S/C25H35F3N6O3/c1-16-11-23(32-34(16)9-4-10-36-3)31-20-12-19(13-21-24(20)30-15-33(21)2)37-18-7-5-17(6-8-18)29-14-22(35)25(26,27)28/h11-13,15,17-18,22,29,35H,4-10,14H2,1-3H3,(H,31,32)/t17-,18+,22-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20E+3n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...

US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
JAK3/JAK1


(Homo sapiens (Human))		BDBM398505
PNG
((2R)-3-{[cis-4-({4-[(1,5-Dimethyl-1H-pyrazol-3-yl)...)
Show SMILES Cc1cc(Nc2cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)F)cc3n(C)cnc23)nn1C
Show InChI InChI=1S/C22H30F2N6O2/c1-13-8-20(28-30(13)3)27-17-9-16(10-18-21(17)26-12-29(18)2)32-15-6-4-14(5-7-15)25-11-19(31)22(23)24/h8-10,12,14-15,19,22,25,31H,4-7,11H2,1-3H3,(H,27,28)/t14-,15+,19-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.14E+3n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...

US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
JAK3/JAK1


(Homo sapiens (Human))		BDBM398502
PNG
((2R)-1,1,1-Trifluoro-3-{[cis-4-({4-[(5-methoxy-1-m...)
Show SMILES COc1cc(Nc2cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)(F)F)cc3n(C)cnc23)nn1C
Show InChI InChI=1S/C22H29F3N6O3/c1-30-12-27-21-16(28-19-10-20(33-3)31(2)29-19)8-15(9-17(21)30)34-14-6-4-13(5-7-14)26-11-18(32)22(23,24)25/h8-10,12-14,18,26,32H,4-7,11H2,1-3H3,(H,28,29)/t13-,14+,18-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.54E+3n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...

US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
JAK3/JAK1


(Homo sapiens (Human))		BDBM398501
PNG
((2R)-1,1,1-Trifluoro-3-({cis-4-[(4-{[1-(3-methoxyp...)
Show SMILES COCCCn1nc(Nc2cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)(F)F)cc3n(C)cnc23)cc1C
Show InChI InChI=1S/C25H35F3N6O3/c1-16-11-23(32-34(16)9-4-10-36-3)31-20-12-19(13-21-24(20)30-15-33(21)2)37-18-7-5-17(6-8-18)29-14-22(35)25(26,27)28/h11-13,15,17-18,22,29,35H,4-10,14H2,1-3H3,(H,31,32)/t17-,18+,22-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.72E+3n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...

US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
JAK3/JAK1


(Homo sapiens (Human))		BDBM398503
PNG
((2R)-3-{[(cis-4-({4-[(Ethyl-5-methyl-1H-pyrazol-3-...)
Show SMILES CCn1nc(Nc2cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)(F)F)cc3n(C)cnc23)cc1C
Show InChI InChI=1S/C23H31F3N6O2/c1-4-32-14(2)9-21(30-32)29-18-10-17(11-19-22(18)28-13-31(19)3)34-16-7-5-15(6-8-16)27-12-20(33)23(24,25)26/h9-11,13,15-16,20,27,33H,4-8,12H2,1-3H3,(H,29,30)/t15-,16+,20-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.16E+3n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...

US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%