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Patent code US10323019

Compile Data Set for Download or QSAR
Found 18 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM398506
PNG
((2R)-1,1,1-Trifluoro-3-({cis-4-[(1-methyl-4-{[1-(p...)
Show SMILES Cn1cnc2c(Nc3ccn(n3)-c3ccccn3)cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)(F)F)cc12
Show InChI InChI=1S/C25H28F3N7O2/c1-34-15-31-24-19(32-22-9-11-35(33-22)23-4-2-3-10-29-23)12-18(13-20(24)34)37-17-7-5-16(6-8-17)30-14-21(36)25(26,27)28/h2-4,9-13,15-17,21,30,36H,5-8,14H2,1H3,(H,32,33)/t16-,17+,21-/m1/s1
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n/an/a 1.49n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...


US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM398504
PNG
((2R)-1,1,1-Trifluoro-3-[(cis-1-methyl-4-{[1-methyl...)
Show SMILES Cn1cnc2c(Nc3cc[nH]n3)cc(O[C@H]3CCC(C)(CC3)NC[C@@H](O)C(F)(F)F)cc12
Show InChI InChI=1/C21H27F3N6O2/c1-20(26-11-17(31)21(22,23)24)6-3-13(4-7-20)32-14-9-15(28-18-5-8-27-29-18)19-16(10-14)30(2)12-25-19/h5,8-10,12-13,17,26,31H,3-4,6-7,11H2,1-2H3,(H2,27,28,29)/t13-,17-,20?/s2
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n/an/a 1.91n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...


US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM398501
PNG
((2R)-1,1,1-Trifluoro-3-({cis-4-[(4-{[1-(3-methoxyp...)
Show SMILES COCCCn1nc(Nc2cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)(F)F)cc3n(C)cnc23)cc1C
Show InChI InChI=1S/C25H35F3N6O3/c1-16-11-23(32-34(16)9-4-10-36-3)31-20-12-19(13-21-24(20)30-15-33(21)2)37-18-7-5-17(6-8-18)29-14-22(35)25(26,27)28/h11-13,15,17-18,22,29,35H,4-10,14H2,1-3H3,(H,31,32)/t17-,18+,22-/m1/s1
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n/an/a 3.25n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...


US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM398502
PNG
((2R)-1,1,1-Trifluoro-3-{[cis-4-({4-[(5-methoxy-1-m...)
Show SMILES COc1cc(Nc2cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)(F)F)cc3n(C)cnc23)nn1C
Show InChI InChI=1S/C22H29F3N6O3/c1-30-12-27-21-16(28-19-10-20(33-3)31(2)29-19)8-15(9-17(21)30)34-14-6-4-13(5-7-14)26-11-18(32)22(23,24)25/h8-10,12-14,18,26,32H,4-7,11H2,1-3H3,(H,28,29)/t13-,14+,18-/m1/s1
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n/an/a 5.25n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...


US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM398505
PNG
((2R)-3-{[cis-4-({4-[(1,5-Dimethyl-1H-pyrazol-3-yl)...)
Show SMILES Cc1cc(Nc2cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)F)cc3n(C)cnc23)nn1C
Show InChI InChI=1S/C22H30F2N6O2/c1-13-8-20(28-30(13)3)27-17-9-16(10-18-21(17)26-12-29(18)2)32-15-6-4-14(5-7-15)25-11-19(31)22(23)24/h8-10,12,14-15,19,22,25,31H,4-7,11H2,1-3H3,(H,27,28)/t14-,15+,19-/m1/s1
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n/an/a 5.35n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...


US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM398503
PNG
((2R)-3-{[(cis-4-({4-[(Ethyl-5-methyl-1H-pyrazol-3-...)
Show SMILES CCn1nc(Nc2cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)(F)F)cc3n(C)cnc23)cc1C
Show InChI InChI=1S/C23H31F3N6O2/c1-4-32-14(2)9-21(30-32)29-18-10-17(11-19-22(18)28-13-31(19)3)34-16-7-5-15(6-8-16)27-12-20(33)23(24,25)26/h9-11,13,15-16,20,27,33H,4-8,12H2,1-3H3,(H,29,30)/t15-,16+,20-/m1/s1
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n/an/a 5.43n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...


US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM398506
PNG
((2R)-1,1,1-Trifluoro-3-({cis-4-[(1-methyl-4-{[1-(p...)
Show SMILES Cn1cnc2c(Nc3ccn(n3)-c3ccccn3)cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)(F)F)cc12
Show InChI InChI=1S/C25H28F3N7O2/c1-34-15-31-24-19(32-22-9-11-35(33-22)23-4-2-3-10-29-23)12-18(13-20(24)34)37-17-7-5-16(6-8-17)30-14-21(36)25(26,27)28/h2-4,9-13,15-17,21,30,36H,5-8,14H2,1H3,(H,32,33)/t16-,17+,21-/m1/s1
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n/an/a 220n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...


US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM398504
PNG
((2R)-1,1,1-Trifluoro-3-[(cis-1-methyl-4-{[1-methyl...)
Show SMILES Cn1cnc2c(Nc3cc[nH]n3)cc(O[C@H]3CCC(C)(CC3)NC[C@@H](O)C(F)(F)F)cc12
Show InChI InChI=1/C21H27F3N6O2/c1-20(26-11-17(31)21(22,23)24)6-3-13(4-7-20)32-14-9-15(28-18-5-8-27-29-18)19-16(10-14)30(2)12-25-19/h5,8-10,12-13,17,26,31H,3-4,6-7,11H2,1-2H3,(H2,27,28,29)/t13-,17-,20?/s2
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n/an/a 239n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...


US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
JAK3/JAK1


(Homo sapiens (Human))
BDBM398506
PNG
((2R)-1,1,1-Trifluoro-3-({cis-4-[(1-methyl-4-{[1-(p...)
Show SMILES Cn1cnc2c(Nc3ccn(n3)-c3ccccn3)cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)(F)F)cc12
Show InChI InChI=1S/C25H28F3N7O2/c1-34-15-31-24-19(32-22-9-11-35(33-22)23-4-2-3-10-29-23)12-18(13-20(24)34)37-17-7-5-16(6-8-17)30-14-21(36)25(26,27)28/h2-4,9-13,15-17,21,30,36H,5-8,14H2,1H3,(H,32,33)/t16-,17+,21-/m1/s1
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n/an/a 660n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...


US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM398505
PNG
((2R)-3-{[cis-4-({4-[(1,5-Dimethyl-1H-pyrazol-3-yl)...)
Show SMILES Cc1cc(Nc2cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)F)cc3n(C)cnc23)nn1C
Show InChI InChI=1S/C22H30F2N6O2/c1-13-8-20(28-30(13)3)27-17-9-16(10-18-21(17)26-12-29(18)2)32-15-6-4-14(5-7-15)25-11-19(31)22(23)24/h8-10,12,14-15,19,22,25,31H,4-7,11H2,1-3H3,(H,27,28)/t14-,15+,19-/m1/s1
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Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...


US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM398502
PNG
((2R)-1,1,1-Trifluoro-3-{[cis-4-({4-[(5-methoxy-1-m...)
Show SMILES COc1cc(Nc2cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)(F)F)cc3n(C)cnc23)nn1C
Show InChI InChI=1S/C22H29F3N6O3/c1-30-12-27-21-16(28-19-10-20(33-3)31(2)29-19)8-15(9-17(21)30)34-14-6-4-13(5-7-14)26-11-18(32)22(23,24)25/h8-10,12-14,18,26,32H,4-7,11H2,1-3H3,(H,28,29)/t13-,14+,18-/m1/s1
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Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...


US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM398503
PNG
((2R)-3-{[(cis-4-({4-[(Ethyl-5-methyl-1H-pyrazol-3-...)
Show SMILES CCn1nc(Nc2cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)(F)F)cc3n(C)cnc23)cc1C
Show InChI InChI=1S/C23H31F3N6O2/c1-4-32-14(2)9-21(30-32)29-18-10-17(11-19-22(18)28-13-31(19)3)34-16-7-5-15(6-8-16)27-12-20(33)23(24,25)26/h9-11,13,15-16,20,27,33H,4-8,12H2,1-3H3,(H,29,30)/t15-,16+,20-/m1/s1
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n/an/a 901n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...


US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
JAK3/JAK1


(Homo sapiens (Human))
BDBM398504
PNG
((2R)-1,1,1-Trifluoro-3-[(cis-1-methyl-4-{[1-methyl...)
Show SMILES Cn1cnc2c(Nc3cc[nH]n3)cc(O[C@H]3CCC(C)(CC3)NC[C@@H](O)C(F)(F)F)cc12
Show InChI InChI=1/C21H27F3N6O2/c1-20(26-11-17(31)21(22,23)24)6-3-13(4-7-20)32-14-9-15(28-18-5-8-27-29-18)19-16(10-14)30(2)12-25-19/h5,8-10,12-13,17,26,31H,3-4,6-7,11H2,1-2H3,(H2,27,28,29)/t13-,17-,20?/s2
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n/an/a 1.17E+3n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...


US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM398501
PNG
((2R)-1,1,1-Trifluoro-3-({cis-4-[(4-{[1-(3-methoxyp...)
Show SMILES COCCCn1nc(Nc2cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)(F)F)cc3n(C)cnc23)cc1C
Show InChI InChI=1S/C25H35F3N6O3/c1-16-11-23(32-34(16)9-4-10-36-3)31-20-12-19(13-21-24(20)30-15-33(21)2)37-18-7-5-17(6-8-18)29-14-22(35)25(26,27)28/h11-13,15,17-18,22,29,35H,4-10,14H2,1-3H3,(H,31,32)/t17-,18+,22-/m1/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...


US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
JAK3/JAK1


(Homo sapiens (Human))
BDBM398505
PNG
((2R)-3-{[cis-4-({4-[(1,5-Dimethyl-1H-pyrazol-3-yl)...)
Show SMILES Cc1cc(Nc2cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)F)cc3n(C)cnc23)nn1C
Show InChI InChI=1S/C22H30F2N6O2/c1-13-8-20(28-30(13)3)27-17-9-16(10-18-21(17)26-12-29(18)2)32-15-6-4-14(5-7-15)25-11-19(31)22(23)24/h8-10,12,14-15,19,22,25,31H,4-7,11H2,1-3H3,(H,27,28)/t14-,15+,19-/m1/s1
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n/an/a 2.14E+3n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...


US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
JAK3/JAK1


(Homo sapiens (Human))
BDBM398502
PNG
((2R)-1,1,1-Trifluoro-3-{[cis-4-({4-[(5-methoxy-1-m...)
Show SMILES COc1cc(Nc2cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)(F)F)cc3n(C)cnc23)nn1C
Show InChI InChI=1S/C22H29F3N6O3/c1-30-12-27-21-16(28-19-10-20(33-3)31(2)29-19)8-15(9-17(21)30)34-14-6-4-13(5-7-14)26-11-18(32)22(23,24)25/h8-10,12-14,18,26,32H,4-7,11H2,1-3H3,(H,28,29)/t13-,14+,18-/m1/s1
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n/an/a 2.54E+3n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...


US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
JAK3/JAK1


(Homo sapiens (Human))
BDBM398501
PNG
((2R)-1,1,1-Trifluoro-3-({cis-4-[(4-{[1-(3-methoxyp...)
Show SMILES COCCCn1nc(Nc2cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)(F)F)cc3n(C)cnc23)cc1C
Show InChI InChI=1S/C25H35F3N6O3/c1-16-11-23(32-34(16)9-4-10-36-3)31-20-12-19(13-21-24(20)30-15-33(21)2)37-18-7-5-17(6-8-18)29-14-22(35)25(26,27)28/h11-13,15,17-18,22,29,35H,4-10,14H2,1-3H3,(H,31,32)/t17-,18+,22-/m1/s1
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n/an/a 3.72E+3n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...


US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
JAK3/JAK1


(Homo sapiens (Human))
BDBM398503
PNG
((2R)-3-{[(cis-4-({4-[(Ethyl-5-methyl-1H-pyrazol-3-...)
Show SMILES CCn1nc(Nc2cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)(F)F)cc3n(C)cnc23)cc1C
Show InChI InChI=1S/C23H31F3N6O2/c1-4-32-14(2)9-21(30-32)29-18-10-17(11-19-22(18)28-13-31(19)3)34-16-7-5-15(6-8-16)27-12-20(33)23(24,25)26/h9-11,13,15-16,20,27,33H,4-8,12H2,1-3H3,(H,29,30)/t15-,16+,20-/m1/s1
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n/an/a 6.16E+3n/an/an/an/an/an/a



Eli Lilly and Company

US Patent


Assay Description
The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...


US Patent US10323019 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%