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Patent code US10323022

Compile Data Set for Download or QSAR

Found 648 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398794
PNG
(US10323022, Example 271)
Show SMILES Cc1c(OC[C@H]2COC(C)(C)O2)nn(c1NC(=O)N[C@H]1CN(CC(F)(F)F)C[C@@H]1c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C29H34F3N5O4/c1-19-25(37(21-12-8-5-9-13-21)35-26(19)39-16-22-17-40-28(2,3)41-22)34-27(38)33-24-15-36(18-29(30,31)32)14-23(24)20-10-6-4-7-11-20/h4-13,22-24H,14-18H2,1-3H3,(H2,33,34,38)/t22-,23+,24-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398800
PNG
(US10323022, Example 277)
Show SMILES COC[C@H](N1C[C@@H](NC(=O)Nc2c(C)c(OC[C@H](C)O)nn2-c2ccccc2)[C@@H](C1)c1ccc(F)c(F)c1)C(F)(F)F
Show InChI InChI=1S/C28H32F5N5O4/c1-16(39)14-42-26-17(2)25(38(36-26)19-7-5-4-6-8-19)35-27(40)34-23-13-37(24(15-41-3)28(31,32)33)12-20(23)18-9-10-21(29)22(30)11-18/h4-11,16,20,23-24,39H,12-15H2,1-3H3,(H2,34,35,40)/t16-,20-,23+,24-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398804
PNG
(1-((3S,4R)-4-(3,5- difluorophenyl)-1-(2- methoxyet...)
Show SMILES COCCCc1nn(c(NC(=O)N[C@@H]2CN(CCOC)C[C@H]2c2cc(F)cc(F)c2)c1C)-c1ccccc1
Show InChI InChI=1S/C28H35F2N5O3/c1-19-25(10-7-12-37-2)33-35(23-8-5-4-6-9-23)27(19)32-28(36)31-26-18-34(11-13-38-3)17-24(26)20-14-21(29)16-22(30)15-20/h4-6,8-9,14-16,24,26H,7,10-13,17-18H2,1-3H3,(H2,31,32,36)/t24-,26+/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398810
PNG
(1-((3S,4R)-4-(4-fluorophenyl)- 1-(2-methoxyethyl)p...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(CCO)nn2-c2ccccc2)[C@@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C26H32FN5O3/c1-18-23(12-14-33)30-32(21-6-4-3-5-7-21)25(18)29-26(34)28-24-17-31(13-15-35-2)16-22(24)19-8-10-20(27)11-9-19/h3-11,22,24,33H,12-17H2,1-2H3,(H2,28,29,34)/t22-,24+/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398827
PNG
(1-(trans-4-(3-chloro-4- fluorophenyl)-1-(2- methox...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2ccn(C)c(=O)c2)C(C1)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C30H32ClFN6O3/c1-19-28(21-11-12-36(2)27(39)16-21)35-38(22-7-5-4-6-8-22)29(19)34-30(40)33-26-18-37(13-14-41-3)17-23(26)20-9-10-25(32)24(31)15-20/h4-12,15-16,23,26H,13-14,17-18H2,1-3H3,(H2,33,34,40)/t23?,26-/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398854
PNG
(1-((3S,4R)-4-(4- fluorophenyl)-1-(2- methoxyethyl)...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2ccccc2)[C@@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C30H32FN5O2/c1-21-28(23-9-5-3-6-10-23)34-36(25-11-7-4-8-12-25)29(21)33-30(37)32-27-20-35(17-18-38-2)19-26(27)22-13-15-24(31)16-14-22/h3-16,26-27H,17-20H2,1-2H3,(H2,32,33,37)/t26-,27+/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398858
PNG
(1-(3-ethoxy-4-methyl-1- phenyl-1H-pyrazol-5-yl)-3-...)
Show SMILES CCOc1nn(c(NC(=O)N[C@@H]2CN(CCOC)CC2c2cccc(c2)C(F)(F)F)c1C)-c1ccccc1
Show InChI InChI=1S/C27H32F3N5O3/c1-4-38-25-18(2)24(35(33-25)21-11-6-5-7-12-21)32-26(36)31-23-17-34(13-14-37-3)16-22(23)19-9-8-10-20(15-19)27(28,29)30/h5-12,15,22-23H,4,13-14,16-17H2,1-3H3,(H2,31,32,36)/t22?,23-/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398868
PNG
(1-(1',4-dimethyl-1-phenyl- 1H,1'H-[3,4'-bipyrazol]...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnn(C)c2)C(C1)c1ccc(F)cn1
Show InChI InChI=1S/C27H31FN8O2/c1-18-25(19-13-30-34(2)15-19)33-36(21-7-5-4-6-8-21)26(18)32-27(37)31-24-17-35(11-12-38-3)16-22(24)23-10-9-20(28)14-29-23/h4-10,13-15,22,24H,11-12,16-17H2,1-3H3,(H2,31,32,37)/t22?,24-/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398870
PNG
(1-((3S,4R)-4-(3,4- difluorophenyl)-1-(2- methoxyet...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2ncn(C)n2)[C@@H](C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C27H30F2N8O2/c1-17-24(25-30-16-35(2)34-25)33-37(19-7-5-4-6-8-19)26(17)32-27(38)31-23-15-36(11-12-39-3)14-20(23)18-9-10-21(28)22(29)13-18/h4-10,13,16,20,23H,11-12,14-15H2,1-3H3,(H2,31,32,38)/t20-,23+/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398891
PNG
(1-((3S,4R)-4-(4-fluorophenyl)- 1-(2-methoxyethyl)p...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(OC[C@H](C)O)nn2-c2ccccc2)[C@@H](C1)c1ccc(F)cc1
Show InChI InChI=1S/C27H34FN5O4/c1-18(34)17-37-26-19(2)25(33(31-26)22-7-5-4-6-8-22)30-27(35)29-24-16-32(13-14-36-3)15-23(24)20-9-11-21(28)12-10-20/h4-12,18,23-24,34H,13-17H2,1-3H3,(H2,29,30,35)/t18-,23-,24+/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398895
PNG
(1-(4-chloro-3-((R)-2- hydroxypropoxy)-1-phenyl- 1H...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(Cl)c(OC[C@@H](C)O)nn2-c2ccccc2)[C@@H](C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C26H30ClF2N5O4/c1-16(35)15-38-25-23(27)24(34(32-25)18-6-4-3-5-7-18)31-26(36)30-22-14-33(10-11-37-2)13-19(22)17-8-9-20(28)21(29)12-17/h3-9,12,16,19,22,35H,10-11,13-15H2,1-2H3,(H2,30,31,36)/t16-,19+,22-/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398953
PNG
(1-(4-bromo-3-methyl-1-phenyl- 1H-pyrazol-5-yl)-3-(...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(Br)c(C)nn2-c2ccccc2)[C@@H](C1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C24H26BrF2N5O2/c1-15-22(25)23(32(30-15)19-6-4-3-5-7-19)29-24(33)28-21-14-31(8-9-34-2)13-20(21)16-10-17(26)12-18(27)11-16/h3-7,10-12,20-21H,8-9,13-14H2,1-2H3,(H2,28,29,33)/t20-,21+/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398958
PNG
(1-(4-bromo-1,3-diphenyl-1H- pyrazol-5-yl)-3-(trans...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(Br)c(nn2-c2ccccc2)-c2ccccc2)[C@@H](C1)c1cncc(F)c1
Show InChI InChI=1S/C28H28BrFN6O2/c1-38-13-12-35-17-23(20-14-21(30)16-31-15-20)24(18-35)32-28(37)33-27-25(29)26(19-8-4-2-5-9-19)34-36(27)22-10-6-3-7-11-22/h2-11,14-16,23-24H,12-13,17-18H2,1H3,(H2,32,33,37)/t23-,24+/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398974
PNG
(US10323022, Example 451)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)[C@H]2C[C@H](O)C2)[C@@H](C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C28H33F2N5O3/c1-17-26(19-12-21(36)13-19)33-35(20-6-4-3-5-7-20)27(17)32-28(37)31-25-16-34(10-11-38-2)15-22(25)18-8-9-23(29)24(30)14-18/h3-9,14,19,21-22,25,36H,10-13,15-16H2,1-2H3,(H2,31,32,37)/t19-,21-,22-,25+/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398982
PNG
(US10323022, Example 459)
Show SMILES CNC(=O)c1nn(c(NC(=O)N[C@@H]2CN(CCOC)C[C@H]2c2ccc(F)c(F)c2)c1C)-c1ccccc1
Show InChI InChI=1S/C26H30F2N6O3/c1-16-23(25(35)29-2)32-34(18-7-5-4-6-8-18)24(16)31-26(36)30-22-15-33(11-12-37-3)14-19(22)17-9-10-20(27)21(28)13-17/h4-10,13,19,22H,11-12,14-15H2,1-3H3,(H,29,35)(H2,30,31,36)/t19-,22+/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM399012
PNG
(1-((3S,4R)-4-(3,4-difluorophenyl)- 1-(2-methoxyeth...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cncc(F)c2)[C@@H](C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C29H29F3N6O2/c1-18-27(20-12-21(30)15-33-14-20)36-38(22-6-4-3-5-7-22)28(18)35-29(39)34-26-17-37(10-11-40-2)16-23(26)19-8-9-24(31)25(32)13-19/h3-9,12-15,23,26H,10-11,16-17H2,1-2H3,(H2,34,35,39)/t23-,26+/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM399021
PNG
(US10323022, Example 498)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnn(c2)C(OCC(F)(F)F)C(F)(F)F)[C@@H](C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C31H31F8N7O3/c1-18-26(20-13-40-45(14-20)28(31(37,38)39)49-17-30(34,35)36)43-46(21-6-4-3-5-7-21)27(18)42-29(47)41-25-16-44(10-11-48-2)15-22(25)19-8-9-23(32)24(33)12-19/h3-9,12-14,22,25,28H,10-11,15-17H2,1-2H3,(H2,41,42,47)/t22-,25+,28?/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM399045
PNG
(US10323022, Example 522)
Show SMILES Cc1c(NC(=O)N[C@H]2CN(CC(F)(F)F)C[C@@H]2c2ccccc2)n(nc1-c1cnc(N)nc1)-c1ccccc1
Show InChI InChI=1S/C27H27F3N8O/c1-17-23(19-12-32-25(31)33-13-19)36-38(20-10-6-3-7-11-20)24(17)35-26(39)34-22-15-37(16-27(28,29)30)14-21(22)18-8-4-2-5-9-18/h2-13,21-22H,14-16H2,1H3,(H2,31,32,33)(H2,34,35,39)/t21-,22+/m1/s1
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n/an/a<100n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM399046
PNG
(US10323022, Example 523)
Show SMILES CCn1cc(cn1)-c1nn(c(NC(=O)N[C@@H]2CN(CCOC)C[C@H]2c2ccc(F)c(F)c2)c1C)-c1ccccc1
Show InChI InChI=1S/C29H33F2N7O2/c1-4-37-16-21(15-32-37)27-19(2)28(38(35-27)22-8-6-5-7-9-22)34-29(39)33-26-18-36(12-13-40-3)17-23(26)20-10-11-24(30)25(31)14-20/h5-11,14-16,23,26H,4,12-13,17-18H2,1-3H3,(H2,33,34,39)/t23-,26+/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM399050
PNG
(US10323022, Example 527)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc(nc2)N(C)C)[C@@H](C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C30H34F2N8O2/c1-19-27(21-15-33-29(34-16-21)38(2)3)37-40(22-8-6-5-7-9-22)28(19)36-30(41)35-26-18-39(12-13-42-4)17-23(26)20-10-11-24(31)25(32)14-20/h5-11,14-16,23,26H,12-13,17-18H2,1-4H3,(H2,35,36,41)/t23-,26+/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM399060
PNG
(US10323022, Example 537)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(OC[C@H](C)O)nn2-c2ccccc2)[C@@H](C1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C27H33F2N5O4/c1-17(35)16-38-26-18(2)25(34(32-26)22-7-5-4-6-8-22)31-27(36)30-24-15-33(9-10-37-3)14-23(24)19-11-20(28)13-21(29)12-19/h4-8,11-13,17,23-24,35H,9-10,14-16H2,1-3H3,(H2,30,31,36)/t17-,23-,24+/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM399069
PNG
(US10323022, Example 546)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(OCCN3CCN(CC3)C(C)=O)nn2-c2ccccc2)[C@@H](C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C32H41F2N7O4/c1-22-30(36-32(43)35-29-21-39(15-17-44-3)20-26(29)24-9-10-27(33)28(34)19-24)41(25-7-5-4-6-8-25)37-31(22)45-18-16-38-11-13-40(14-12-38)23(2)42/h4-10,19,26,29H,11-18,20-21H2,1-3H3,(H2,35,36,43)/t26-,29+/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM399077
PNG
(US10323022, Example 554)
Show SMILES CNC(=O)c1nn(c(NC(=O)N[C@@H]2CN(CCOC)C[C@H]2c2ccc(F)c(F)c2)c1Br)-c1ccccc1
Show InChI InChI=1S/C25H27BrF2N6O3/c1-29-24(35)22-21(26)23(34(32-22)16-6-4-3-5-7-16)31-25(36)30-20-14-33(10-11-37-2)13-17(20)15-8-9-18(27)19(28)12-15/h3-9,12,17,20H,10-11,13-14H2,1-2H3,(H,29,35)(H2,30,31,36)/t17-,20+/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM399141
PNG
(US10323022, Example 618)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C#N)c(=O)[nH]n2-c2ccccc2)[C@@H](C1)c1ccc(F)c(F)c1
Show InChI InChI=1/C24H24F2N6O3/c1-35-10-9-31-13-18(15-7-8-19(25)20(26)11-15)21(14-31)28-24(34)29-22-17(12-27)23(33)30-32(22)16-5-3-2-4-6-16/h2-8,11,18,21H,9-10,13-14H2,1H3,(H,30,33)(H2,28,29,34)/t18-,21+/s2
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM399160
PNG
(1-((3S,4R)-4-(3,4- difluorophenyl)-1-(2- methoxyet...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2cnn3ccccc23)[C@@H](C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C21H23F2N5O2/c1-30-9-8-27-12-15(14-5-6-16(22)17(23)10-14)19(13-27)26-21(29)25-18-11-24-28-7-3-2-4-20(18)28/h2-7,10-11,15,19H,8-9,12-13H2,1H3,(H2,25,26,29)/t15-,19+/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM399161
PNG
(1-((3S,4R)-4-(3,4- difluorophenyl)-1-(2- methoxyet...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)n(nc2-c2ccccc2)-c2cnccn2)[C@@H](C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C28H29F2N7O2/c1-18-26(27(19-6-4-3-5-7-19)35-37(18)25-15-31-10-11-32-25)34-28(38)33-24-17-36(12-13-39-2)16-21(24)20-8-9-22(29)23(30)14-20/h3-11,14-15,21,24H,12-13,16-17H2,1-2H3,(H2,33,34,38)/t21-,24+/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM399163
PNG
(1-((3S,4R)-4-(3,5- difluorophenyl)-1-(2- methoxyet...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)n(C)nc2-c2ccccc2)[C@@H](C1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C25H29F2N5O2/c1-16-23(24(30-31(16)2)17-7-5-4-6-8-17)29-25(33)28-22-15-32(9-10-34-3)14-21(22)18-11-19(26)13-20(27)12-18/h4-8,11-13,21-22H,9-10,14-15H2,1-3H3,(H2,28,29,33)/t21-,22+/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM399168
PNG
(1-((3S,4R)-4-(3,4- difluorophenyl)-1-(2- methoxyet...)
Show SMILES CCn1nc(C)c(NC(=O)N[C@@H]2CN(CCOC)C[C@H]2c2ccc(F)c(F)c2)c1-c1ccccc1
Show InChI InChI=1S/C26H31F2N5O2/c1-4-33-25(18-8-6-5-7-9-18)24(17(2)31-33)30-26(34)29-23-16-32(12-13-35-3)15-20(23)19-10-11-21(27)22(28)14-19/h5-11,14,20,23H,4,12-13,15-16H2,1-3H3,(H2,29,30,34)/t20-,23+/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398530
PNG
(1-(3-cyclopropyl-1-phenyl- 1H-pyrazol-5-yl)-3-(tra...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2cc(nn2-c2ccccc2)C2CC2)[C@@H](C1)c1ccccc1
Show InChI InChI=1S/C26H31N5O2/c1-33-15-14-30-17-22(19-8-4-2-5-9-19)24(18-30)27-26(32)28-25-16-23(20-12-13-20)29-31(25)21-10-6-3-7-11-21/h2-11,16,20,22,24H,12-15,17-18H2,1H3,(H2,27,28,32)/t22-,24+/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398581
PNG
(1-(3-(4-cyanophenyl)-1- methyl-1H-pyrazol-5-yl)- 3...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2cc(nn2C)-c2ccc(cc2)C#N)[C@@H](C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C25H26F2N6O2/c1-32-24(12-22(31-32)17-5-3-16(13-28)4-6-17)30-25(34)29-23-15-33(9-10-35-2)14-19(23)18-7-8-20(26)21(27)11-18/h3-8,11-12,19,23H,9-10,14-15H2,1-2H3,(H2,29,30,34)/t19-,23+/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398593
PNG
(1-((3S,4R)-4-(3,4- difluorophenyl)-1-(2- methoxyet...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2cc(nn2-c2ccccc2)-c2cnn(C)c2)[C@@H](C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C27H29F2N7O2/c1-34-15-19(14-30-34)24-13-26(36(33-24)20-6-4-3-5-7-20)32-27(37)31-25-17-35(10-11-38-2)16-21(25)18-8-9-22(28)23(29)12-18/h3-9,12-15,21,25H,10-11,16-17H2,1-2H3,(H2,31,32,37)/t21-,25+/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398597
PNG
(1-((3S,4R)-4-(3,4- difluorophenyl)-1-(2- methoxyet...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(OC[C@@H]3COC(C)(C)O3)nn2-c2ccccc2)[C@@H](C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C30H37F2N5O5/c1-19-27(37(21-8-6-5-7-9-21)35-28(19)40-17-22-18-41-30(2,3)42-22)34-29(38)33-26-16-36(12-13-39-4)15-23(26)20-10-11-24(31)25(32)14-20/h5-11,14,22-23,26H,12-13,15-18H2,1-4H3,(H2,33,34,38)/t22-,23+,26-/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398539
PNG
(1-(3,4-dimethyl-1-phenyl- 1H-pyrazol-5-yl)-3-(tran...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(C)nn2-c2ccccc2)[C@@H](C1)c1ccccc1
Show InChI InChI=1S/C25H31N5O2/c1-18-19(2)28-30(21-12-8-5-9-13-21)24(18)27-25(31)26-23-17-29(14-15-32-3)16-22(23)20-10-6-4-7-11-20/h4-13,22-23H,14-17H2,1-3H3,(H2,26,27,31)/t22-,23+/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398610
PNG
(1-((3S,4R)-4-(3,5-difluoro- phenyl)-1-(2-methoxyet...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c3COCc3nn2-c2ccccc2)[C@@H](C1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C25H27F2N5O3/c1-34-8-7-31-12-20(16-9-17(26)11-18(27)10-16)22(13-31)28-25(33)29-24-21-14-35-15-23(21)30-32(24)19-5-3-2-4-6-19/h2-6,9-11,20,22H,7-8,12-15H2,1H3,(H2,28,29,33)/t20-,22+/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398616
PNG
(1-((3S,4R)-4-(3,4-difluoro- phenyl)-1-(2-methoxyet...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2cc(nn2C)-c2ccccc2)[C@@H](C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C24H27F2N5O2/c1-30-23(13-21(29-30)16-6-4-3-5-7-16)28-24(32)27-22-15-31(10-11-33-2)14-18(22)17-8-9-19(25)20(26)12-17/h3-9,12-13,18,22H,10-11,14-15H2,1-2H3,(H2,27,28,32)/t18-,22+/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398618
PNG
(1-((3S,4R)-1-(2-methoxy- ethyl)-4-phenylpyrrolidin...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c3CS(=O)Cc3nn2-c2ccccc2)[C@@H](C1)c1ccccc1
Show InChI InChI=1S/C25H29N5O3S/c1-33-13-12-29-14-20(18-8-4-2-5-9-18)22(15-29)26-25(31)27-24-21-16-34(32)17-23(21)28-30(24)19-10-6-3-7-11-19/h2-11,20,22H,12-17H2,1H3,(H2,26,27,31)/t20-,22+,34?/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398619
PNG
(1-((3S,4R)-1-(2-methoxy- ethyl)-4-phenylpyrrolidin...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2cc(nn2C)-c2ccncc2)[C@@H](C1)c1ccccc1
Show InChI InChI=1S/C23H28N6O2/c1-28-22(14-20(27-28)18-8-10-24-11-9-18)26-23(30)25-21-16-29(12-13-31-2)15-19(21)17-6-4-3-5-7-17/h3-11,14,19,21H,12-13,15-16H2,1-2H3,(H2,25,26,30)/t19-,21+/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398626
PNG
(1-((3S,4R)-4-(3,4- difluorophenyl)-1-(2- methoxyet...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2cc(nn2C)-c2cccc(C)c2)[C@@H](C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C25H29F2N5O2/c1-16-5-4-6-18(11-16)22-13-24(31(2)30-22)29-25(33)28-23-15-32(9-10-34-3)14-19(23)17-7-8-20(26)21(27)12-17/h4-8,11-13,19,23H,9-10,14-15H2,1-3H3,(H2,28,29,33)/t19-,23+/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398634
PNG
(1-((3S,4R)-4-(2,4- difluorophenyl)-1-(2- methoxyet...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2cc(nn2C)-c2ccccc2)[C@@H](C1)c1ccc(F)cc1F
Show InChI InChI=1S/C24H27F2N5O2/c1-30-23(13-21(29-30)16-6-4-3-5-7-16)28-24(32)27-22-15-31(10-11-33-2)14-19(22)18-9-8-17(25)12-20(18)26/h3-9,12-13,19,22H,10-11,14-15H2,1-2H3,(H2,27,28,32)/t19-,22+/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398639
PNG
(1-((3S,4R)-4-(3-fluoro- phenyl)-1-(2-methoxy- ethy...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c3CCCc3nn2-c2ccccc2)[C@@H](C1)c1cccc(F)c1
Show InChI InChI=1S/C26H30FN5O2/c1-34-14-13-31-16-22(18-7-5-8-19(27)15-18)24(17-31)28-26(33)29-25-21-11-6-12-23(21)30-32(25)20-9-3-2-4-10-20/h2-5,7-10,15,22,24H,6,11-14,16-17H2,1H3,(H2,28,29,33)/t22-,24+/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398644
PNG
(US10323022, Example 121 | methyl 4-(5-(3-((3S,4R)-...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2cc(nn2C)-c2ccc(cc2)C(=O)OC)[C@@H](C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C26H29F2N5O4/c1-32-24(13-22(31-32)16-4-6-17(7-5-16)25(34)37-3)30-26(35)29-23-15-33(10-11-36-2)14-19(23)18-8-9-20(27)21(28)12-18/h4-9,12-13,19,23H,10-11,14-15H2,1-3H3,(H2,29,30,35)/t19-,23+/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM50232542
PNG
(CHEMBL4090531 | US10323022, Example 135)
Show SMILES CCOc1nn(c(NC(=O)N[C@@H]2CN(CCOC)C[C@H]2c2ccc(F)c(F)c2)c1C)-c1ccccc1
Show InChI InChI=1/C26H31F2N5O3/c1-4-36-25-17(2)24(33(31-25)19-8-6-5-7-9-19)30-26(34)29-23-16-32(12-13-35-3)15-20(23)18-10-11-21(27)22(28)14-18/h5-11,14,20,23H,4,12-13,15-16H2,1-3H3,(H2,29,30,34)/t20-,23+/s2
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n/an/a<100n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398664
PNG
(1-(3-(cyanomethoxy)- 4-methyl-1-phenyl-1H- pyrazol...)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c(C)c(OCC#N)nn2-c2ccccc2)[C@@H](C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C26H28F2N6O3/c1-17-24(34(19-6-4-3-5-7-19)32-25(17)37-12-10-29)31-26(35)30-23-16-33(11-13-36-2)15-20(23)18-8-9-21(27)22(28)14-18/h3-9,14,20,23H,11-13,15-16H2,1-2H3,(H2,30,31,35)/t20-,23+/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398674
PNG
(US10323022, Example 151)
Show SMILES COCCN1C[C@@H](NC(=O)Nc2c3CCCc3nn2-c2ccncc2)[C@@H](C1)c1ccccc1
Show InChI InChI=1S/C25H30N6O2/c1-33-15-14-30-16-21(18-6-3-2-4-7-18)23(17-30)27-25(32)28-24-20-8-5-9-22(20)29-31(24)19-10-12-26-13-11-19/h2-4,6-7,10-13,21,23H,5,8-9,14-17H2,1H3,(H2,27,28,32)/t21-,23+/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398733
PNG
(US10323022, Example 210)
Show SMILES Fc1ccc(cc1)C1CN(CC(F)(F)F)C[C@H]1NC(=O)Nc1c2CCCc2nn1-c1ccccc1
Show InChI InChI=1S/C25H25F4N5O/c26-17-11-9-16(10-12-17)20-13-33(15-25(27,28)29)14-22(20)30-24(35)31-23-19-7-4-8-21(19)32-34(23)18-5-2-1-3-6-18/h1-3,5-6,9-12,20,22H,4,7-8,13-15H2,(H2,30,31,35)/t20?,22-/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398748
PNG
(1-((3S,4R)-4-(3,4- difluorophenyl)-1-(1H-pyrazol- ...)
Show SMILES COCCCc1nn(c(NC(=O)N[C@@H]2CN(C[C@H]2c2ccc(F)c(F)c2)c2cn[nH]c2)c1C)-c1ccccc1
Show InChI InChI=1/C28H31F2N7O2/c1-18-25(9-6-12-39-2)35-37(20-7-4-3-5-8-20)27(18)34-28(38)33-26-17-36(21-14-31-32-15-21)16-22(26)19-10-11-23(29)24(30)13-19/h3-5,7-8,10-11,13-15,22,26H,6,9,12,16-17H2,1-2H3,(H,31,32)(H2,33,34,38)/t22-,26+/s2
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398778
PNG
(US10323022, Example 255)
Show SMILES CCOc1nn(c(NC(=O)N[C@@H]2CN(C[C@H]2c2ccc(F)c(F)c2)C(C)COC)c1C)-c1ccccc1
Show InChI InChI=1S/C27H33F2N5O3/c1-5-37-26-18(3)25(34(32-26)20-9-7-6-8-10-20)31-27(35)30-24-15-33(17(2)16-36-4)14-21(24)19-11-12-22(28)23(29)13-19/h6-13,17,21,24H,5,14-16H2,1-4H3,(H2,30,31,35)/t17?,21-,24+/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398786
PNG
(US10323022, Example 263)
Show SMILES CCOc1nn(c(NC(=O)N[C@@H]2CN(C[C@H]2c2ccc(F)c(F)c2)C(CO)COC)c1C)-c1ccccc1
Show InChI InChI=1S/C27H33F2N5O4/c1-4-38-26-17(2)25(34(32-26)19-8-6-5-7-9-19)31-27(36)30-24-14-33(20(15-35)16-37-3)13-21(24)18-10-11-22(28)23(29)12-18/h5-12,20-21,24,35H,4,13-16H2,1-3H3,(H2,30,31,36)/t20?,21-,24+/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398787
PNG
(US10323022, Example 264)
Show SMILES COCC(CO)N1C[C@@H](NC(=O)Nc2c(Cl)c(nn2-c2ccccc2)-c2cnn(C)c2)[C@@H](C1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C28H30ClF2N7O3/c1-36-12-18(11-32-36)26-25(29)27(38(35-26)19-6-4-3-5-7-19)34-28(40)33-24-14-37(20(15-39)16-41-2)13-21(24)17-8-9-22(30)23(31)10-17/h3-12,20-21,24,39H,13-16H2,1-2H3,(H2,33,34,40)/t20?,21-,24+/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM398792
PNG
(US10323022, Example 269)
Show SMILES Cc1c(NC(=O)N[C@H]2CN(CC(F)(F)F)C[C@@H]2c2ccccc2)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C27H28F3N7O/c1-18-24(20-13-31-35(2)14-20)34-37(21-11-7-4-8-12-21)25(18)33-26(38)32-23-16-36(17-27(28,29)30)15-22(23)19-9-5-3-6-10-19/h3-14,22-23H,15-17H2,1-2H3,(H2,32,33,38)/t22-,23+/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (TrkA from Invitrogen Corp.) and test compound ...


US Patent US10323022 (2019)

More data for this
Ligand-Target Pair
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