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Patent code US10323023

Compile Data Set for Download or QSAR
Found 19 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM399177
PNG
(US10323023, Compound TDI01180)
Show SMILES Clc1nnccc1NC(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C24H16ClN9O/c25-22-18(5-8-27-34-22)31-24(35)20-10-13-1-2-14(11-19(13)30-20)23-26-7-6-21(32-23)29-16-3-4-17-15(9-16)12-28-33-17/h1-12,30H,(H,28,33)(H,26,29,32)(H,27,31,35)
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US Patent
n/an/a 37n/an/an/an/an/an/a



Beijing Tide Pharmaceutical Co., Ltd.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10323023 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM399181
PNG
(US10323023, Compound TDI01201)
Show SMILES Cn1c(cc2ccc(cc12)-c1nccc(Nc2ccc3[nH]ncc3c2)n1)C(=O)Nc1ccnnc1
Show InChI InChI=1S/C25H19N9O/c1-34-21-12-16(3-2-15(21)11-22(34)25(35)31-19-6-9-27-28-14-19)24-26-8-7-23(32-24)30-18-4-5-20-17(10-18)13-29-33-20/h2-14H,1H3,(H,29,33)(H,26,30,32)(H,27,31,35)
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US Patent
n/an/a 48n/an/an/an/an/an/a



Beijing Tide Pharmaceutical Co., Ltd.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10323023 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM399127
PNG
(US10323023, Compound TDI01152)
Show SMILES O=C(Nc1ccnnc1)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C24H17N9O/c34-24(30-18-5-8-26-27-13-18)21-10-14-1-2-15(11-20(14)31-21)23-25-7-6-22(32-23)29-17-3-4-19-16(9-17)12-28-33-19/h1-13,31H,(H,28,33)(H,25,29,32)(H,26,30,34)
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US Patent
n/an/a 88n/an/an/an/an/an/a



Beijing Tide Pharmaceutical Co., Ltd.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10323023 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM399178
PNG
(US10323023, Compound TDI01181)
Show SMILES Clc1cnncc1NC(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C24H16ClN9O/c25-17-11-27-28-12-21(17)32-24(35)20-8-13-1-2-14(9-19(13)31-20)23-26-6-5-22(33-23)30-16-3-4-18-15(7-16)10-29-34-18/h1-12,31H,(H,29,34)(H,26,30,33)(H,27,32,35)
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US Patent
n/an/a 92n/an/an/an/an/an/a



Beijing Tide Pharmaceutical Co., Ltd.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10323023 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM399187
PNG
(US10323023, Compound TDI01251)
Show SMILES Cc1cc(Nc2ccc3[nH]ncc3c2)nc(n1)-c1ccc2cc([nH]c2c1)C(=O)Nc1ccnnc1
Show InChI InChI=1S/C25H19N9O/c1-14-8-23(30-18-4-5-20-17(9-18)12-28-34-20)33-24(29-14)16-3-2-15-10-22(32-21(15)11-16)25(35)31-19-6-7-26-27-13-19/h2-13,32H,1H3,(H,28,34)(H,26,31,35)(H,29,30,33)
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US Patent
n/an/a 101n/an/an/an/an/an/a



Beijing Tide Pharmaceutical Co., Ltd.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10323023 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM399188
PNG
(US10323023, Compound TDI01276)
Show SMILES Cc1c(Nc2ccnc(n2)-c2ccc3cc([nH]c3c2)C(=O)Nc2ccnnc2)ccc2[nH]ncc12
Show InChI InChI=1S/C25H19N9O/c1-14-18-13-29-34-20(18)5-4-19(14)32-23-7-8-26-24(33-23)16-3-2-15-10-22(31-21(15)11-16)25(35)30-17-6-9-27-28-12-17/h2-13,31H,1H3,(H,29,34)(H,26,32,33)(H,27,30,35)
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n/an/a 113n/an/an/an/an/an/a



Beijing Tide Pharmaceutical Co., Ltd.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10323023 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM399179
PNG
(US10323023, Compound TDI01188)
Show SMILES O=C(Nc1ccnnc1)c1cc2cc(ccc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C24H17N9O/c34-24(30-18-5-8-26-27-13-18)21-11-15-9-14(1-3-19(15)31-21)23-25-7-6-22(32-23)29-17-2-4-20-16(10-17)12-28-33-20/h1-13,31H,(H,28,33)(H,25,29,32)(H,26,30,34)
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Beijing Tide Pharmaceutical Co., Ltd.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10323023 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM399184
PNG
(US10323023, Compound TDI01236)
Show SMILES O=C(Nc1ccnnc1)c1ccc2ccc(cc2n1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C25H17N9O/c35-25(31-19-7-10-27-28-14-19)21-5-3-15-1-2-16(12-22(15)32-21)24-26-9-8-23(33-24)30-18-4-6-20-17(11-18)13-29-34-20/h1-14H,(H,29,34)(H,26,30,33)(H,27,31,35)
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Beijing Tide Pharmaceutical Co., Ltd.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10323023 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM399176
PNG
(US10323023, Compound TDI01178)
Show SMILES O=C(NCc1ccnnc1)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C25H19N9O/c35-25(27-12-15-5-8-28-29-13-15)22-10-16-1-2-17(11-21(16)32-22)24-26-7-6-23(33-24)31-19-3-4-20-18(9-19)14-30-34-20/h1-11,13-14,32H,12H2,(H,27,35)(H,30,34)(H,26,31,33)
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n/an/a 168n/an/an/an/an/an/a



Beijing Tide Pharmaceutical Co., Ltd.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10323023 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM399185
PNG
(US10323023, Compound TDI01237)
Show SMILES O=C(Nc1ccnnc1)N1Cc2ccc(cc2C1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C24H19N9O/c34-24(30-20-5-8-26-27-12-20)33-13-16-2-1-15(9-18(16)14-33)23-25-7-6-22(31-23)29-19-3-4-21-17(10-19)11-28-32-21/h1-12H,13-14H2,(H,28,32)(H,25,29,31)(H,26,30,34)
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n/an/a 171n/an/an/an/an/an/a



Beijing Tide Pharmaceutical Co., Ltd.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10323023 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM399175
PNG
(US10323023, Compound TDI01175)
Show SMILES O=C(Nc1ccnnc1)c1cc2ccc(cc2[nH]1)C1NC(Nc2ccc3[nH]ncc3c2)=c2sccc2=N1
Show InChI InChI=1/C26H19N9OS/c36-26(31-18-5-7-27-28-13-18)22-10-14-1-2-15(11-21(14)32-22)24-33-20-6-8-37-23(20)25(34-24)30-17-3-4-19-16(9-17)12-29-35-19/h1-13,24,30,32,34H,(H,29,35)(H,27,31,36)
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Beijing Tide Pharmaceutical Co., Ltd.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10323023 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM399186
PNG
(US10323023, Compound TDI01250)
Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1ccc2cc([nH]c2c1)C(=O)Nc1ccnnc1
Show InChI InChI=1S/C25H19N9O/c1-14-11-26-24(33-23(14)30-18-4-5-20-17(8-18)12-29-34-20)16-3-2-15-9-22(32-21(15)10-16)25(35)31-19-6-7-27-28-13-19/h2-13,32H,1H3,(H,29,34)(H,26,30,33)(H,27,31,35)
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Beijing Tide Pharmaceutical Co., Ltd.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10323023 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM399174
PNG
(US10323023, Compound TDI01167)
Show SMILES O=C(Nc1ccnnc1)c1cc2ccc(cc2[nH]1)-c1ncnc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C23H16N10O/c34-22(29-17-5-6-26-27-11-17)20-8-13-1-2-14(9-19(13)31-20)21-24-12-25-23(32-21)30-16-3-4-18-15(7-16)10-28-33-18/h1-12,31H,(H,28,33)(H,26,29,34)(H,24,25,30,32)
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n/an/a 223n/an/an/an/an/an/a



Beijing Tide Pharmaceutical Co., Ltd.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10323023 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM399180
PNG
(US10323023, Compound TDI01191)
Show SMILES O=C(Nc1ccnnc1)c1c[nH]c2ccc(cc12)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C24H17N9O/c34-24(31-17-5-8-27-28-12-17)19-13-26-21-3-1-14(10-18(19)21)23-25-7-6-22(32-23)30-16-2-4-20-15(9-16)11-29-33-20/h1-13,26H,(H,29,33)(H,25,30,32)(H,27,31,34)
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n/an/a 225n/an/an/an/an/an/a



Beijing Tide Pharmaceutical Co., Ltd.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10323023 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM398658
PNG
(US10323023, Compound TDI01116)
Show SMILES O=C(Nc1ccnnc1)c1cc2ccc(cc2s1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C24H16N8OS/c33-24(30-18-5-8-26-27-13-18)21-10-14-1-2-15(11-20(14)34-21)23-25-7-6-22(31-23)29-17-3-4-19-16(9-17)12-28-32-19/h1-13H,(H,28,32)(H,25,29,31)(H,26,30,33)
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Beijing Tide Pharmaceutical Co., Ltd.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10323023 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM399182
PNG
(US10323023, Compound TDI01213)
Show SMILES Fc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1ccc2cc([nH]c2c1)C(=O)Nc1ccnnc1
Show InChI InChI=1S/C24H16FN9O/c25-18-12-26-22(33-23(18)30-16-3-4-19-15(7-16)10-29-34-19)14-2-1-13-8-21(32-20(13)9-14)24(35)31-17-5-6-27-28-11-17/h1-12,32H,(H,29,34)(H,26,30,33)(H,27,31,35)
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Beijing Tide Pharmaceutical Co., Ltd.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10323023 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM399183
PNG
(US10323023, Compound TDI01232)
Show SMILES Cc1nc(nc(Nc2ccc3[nH]ncc3c2)c1C)-c1ccc2cc([nH]c2c1)C(=O)Nc1ccnnc1
Show InChI InChI=1S/C26H21N9O/c1-14-15(2)30-25(34-24(14)31-19-5-6-21-18(9-19)12-29-35-21)17-4-3-16-10-23(33-22(16)11-17)26(36)32-20-7-8-27-28-13-20/h3-13,33H,1-2H3,(H,29,35)(H,27,32,36)(H,30,31,34)
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Beijing Tide Pharmaceutical Co., Ltd.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10323023 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM399189
PNG
(US10323023, Compound TDI01347)
Show SMILES CN(C(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1)c1ccnnc1
Show InChI InChI=1S/C25H19N9O/c1-34(19-6-9-27-28-14-19)25(35)22-11-15-2-3-16(12-21(15)31-22)24-26-8-7-23(32-24)30-18-4-5-20-17(10-18)13-29-33-20/h2-14,31H,1H3,(H,29,33)(H,26,30,32)
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Beijing Tide Pharmaceutical Co., Ltd.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10323023 (2019)

More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM399173
PNG
(US10323023, Compound TDI01164)
Show SMILES O=C(Nc1ccnnc1)c1cc2ccc(cc2[nH]1)-c1nc(Nc2ccc3[nH]ncc3c2)cc2nccn12
Show InChI InChI=1S/C26H18N10O/c37-26(32-19-5-6-28-29-14-19)22-10-15-1-2-16(11-21(15)33-22)25-34-23(12-24-27-7-8-36(24)25)31-18-3-4-20-17(9-18)13-30-35-20/h1-14,31,33H,(H,30,35)(H,28,32,37)
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Beijing Tide Pharmaceutical Co., Ltd.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10323023 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%