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Patent code US10323028

Compile Data Set for Download or QSAR
Found 67 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416667
PNG
((2R)-2-Methoxy-2-[3-methoxy-5-(trifluoromethoxy)ph...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cc(OC)cc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H22F3N7O4S/c1-33-14-8-12(9-15(10-14)35-21(22,23)24)17(34-2)18(32)27-20-30-29-19(36-20)26-13-5-7-31(11-13)16-4-3-6-25-28-16/h3-4,6,8-10,13,17H,5,7,11H2,1-2H3,(H,26,29)(H,27,30,32)/t13-,17-/m1/s1
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n/an/a 6.11n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416666
PNG
((2S)-2-Methoxy-2-[3-methoxy-5-(trifluoromethoxy)ph...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cc(OC)cc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H22F3N7O4S/c1-33-14-8-12(9-15(10-14)35-21(22,23)24)17(34-2)18(32)27-20-30-29-19(36-20)26-13-5-7-31(11-13)16-4-3-6-25-28-16/h3-4,6,8-10,13,17H,5,7,11H2,1-2H3,(H,26,29)(H,27,30,32)/t13-,17+/m1/s1
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n/an/a 6.35n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416686
PNG
((2S)-2-(3,5-Dimethoxyphenyl)-2-methoxy-N-[5-[[(3R)...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C21H25N7O4S/c1-30-15-9-13(10-16(11-15)31-2)18(32-3)19(29)24-21-27-26-20(33-21)23-14-6-8-28(12-14)17-5-4-7-22-25-17/h4-5,7,9-11,14,18H,6,8,12H2,1-3H3,(H,23,26)(H,24,27,29)/t14-,18+/m1/s1
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n/an/a 20n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416690
PNG
(2-(3,5-dimethoxyphenyl)-2-methoxy-N-[5-[[(3R)-1-py...)
Show SMILES COC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C21H25N7O4S/c1-30-15-9-13(10-16(11-15)31-2)18(32-3)19(29)24-21-27-26-20(33-21)23-14-6-8-28(12-14)17-5-4-7-22-25-17/h4-5,7,9-11,14,18H,6,8,12H2,1-3H3,(H,23,26)(H,24,27,29)/t14-,18?/m1/s1
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n/an/a 20n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416638
PNG
((2S)-2-[3-(3-Fluoroazetidin-1-yl)phenyl]-2-methoxy...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)N1CC(F)C1
Show InChI InChI=1S/C22H25FN8O2S/c1-33-19(14-4-2-5-17(10-14)31-11-15(23)12-31)20(32)26-22-29-28-21(34-22)25-16-7-9-30(13-16)18-6-3-8-24-27-18/h2-6,8,10,15-16,19H,7,9,11-13H2,1H3,(H,25,28)(H,26,29,32)/t16-,19+/m1/s1
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n/an/a 20.6n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416680
PNG
((2S)-2-Methoxy-2-[3-(oxetan-3-yl)phenyl]-N-[5-[[(3...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)C1COC1
Show InChI InChI=1S/C22H25N7O3S/c1-31-19(15-5-2-4-14(10-15)16-12-32-13-16)20(30)25-22-28-27-21(33-22)24-17-7-9-29(11-17)18-6-3-8-23-26-18/h2-6,8,10,16-17,19H,7,9,11-13H2,1H3,(H,24,27)(H,25,28,30)/t17-,19+/m1/s1
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n/an/a 22.6n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416693
PNG
(2-(3,5-dimethoxyphenyl)-N-[5-[[(3R)-1-(6-fluoropyr...)
Show SMILES COC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(F)nn2)s1)c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C21H24FN7O4S/c1-31-14-8-12(9-15(10-14)32-2)18(33-3)19(30)24-21-28-27-20(34-21)23-13-6-7-29(11-13)17-5-4-16(22)25-26-17/h4-5,8-10,13,18H,6-7,11H2,1-3H3,(H,23,27)(H,24,28,30)/t13-,18?/m1/s1
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n/an/a 23.5n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416676
PNG
((2S)-2-(3,5-Dimethoxyphenyl)-2-methoxy-N-[5-[[(3R)...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C20H24N8O4S/c1-30-14-8-12(9-15(10-14)31-2)16(32-3)17(29)24-20-27-26-19(33-20)23-13-4-7-28(11-13)18-21-5-6-22-25-18/h5-6,8-10,13,16H,4,7,11H2,1-3H3,(H,23,26)(H,24,27,29)/t13-,16+/m1/s1
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n/an/a 25.2n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416654
PNG
((2S)-2-(3,5-Dimethoxyphenyl)-2-ethoxy-N-[5-[[(3R)-...)
Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C22H27N7O4S/c1-4-33-19(14-10-16(31-2)12-17(11-14)32-3)20(30)25-22-28-27-21(34-22)24-15-7-9-29(13-15)18-6-5-8-23-26-18/h5-6,8,10-12,15,19H,4,7,9,13H2,1-3H3,(H,24,27)(H,25,28,30)/t15-,19+/m1/s1
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n/an/a 28n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416652
PNG
((2R)-3-Methoxy-2-(3-methoxyphenyl)-N-[5-[[(3R)-1-p...)
Show SMILES COC[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC)c1
Show InChI InChI=1S/C21H25N7O3S/c1-30-13-17(14-5-3-6-16(11-14)31-2)19(29)24-21-27-26-20(32-21)23-15-8-10-28(12-15)18-7-4-9-22-25-18/h3-7,9,11,15,17H,8,10,12-13H2,1-2H3,(H,23,26)(H,24,27,29)/t15-,17+/m1/s1
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n/an/a 28.8n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416643
PNG
((2S)-2-Methoxy-2-[3-(3-methoxyazetidin-1-yl)phenyl...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)N1CC(C1)OC
Show InChI InChI=1S/C23H28N8O3S/c1-33-18-13-31(14-18)17-6-3-5-15(11-17)20(34-2)21(32)26-23-29-28-22(35-23)25-16-8-10-30(12-16)19-7-4-9-24-27-19/h3-7,9,11,16,18,20H,8,10,12-14H2,1-2H3,(H,25,28)(H,26,29,32)/t16-,20+/m1/s1
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n/an/a 30.8n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416664
PNG
((2S)-2-[3-(3-Fluoroazetidin-1-yl)-5-methoxy-phenyl...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cc(OC)cc(c1)N1CC(F)C1
Show InChI InChI=1S/C23H27FN8O3S/c1-34-18-9-14(8-17(10-18)32-11-15(24)12-32)20(35-2)21(33)27-23-30-29-22(36-23)26-16-5-7-31(13-16)19-4-3-6-25-28-19/h3-4,6,8-10,15-16,20H,5,7,11-13H2,1-2H3,(H,26,29)(H,27,30,33)/t16-,20-/m1/s1
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n/an/a 34.9n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416682
PNG
((2S)-2-Ethoxy-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolid...)
Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H22F3N7O3S/c1-2-33-17(13-5-3-6-15(11-13)34-21(22,23)24)18(32)27-20-30-29-19(35-20)26-14-8-10-31(12-14)16-7-4-9-25-28-16/h3-7,9,11,14,17H,2,8,10,12H2,1H3,(H,26,29)(H,27,30,32)/t14-,17+/m1/s1
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n/an/a 40.1n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416650
PNG
((2S)-2-(3,5-Dimethoxyphenyl)-2-methoxy-N-[5-[[(3R)...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C22H27N7O4S/c1-13-5-6-18(26-25-13)29-8-7-15(12-29)23-21-27-28-22(34-21)24-20(30)19(33-4)14-9-16(31-2)11-17(10-14)32-3/h5-6,9-11,15,19H,7-8,12H2,1-4H3,(H,23,27)(H,24,28,30)/t15-,19+/m1/s1
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n/an/a 42.3n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416668
PNG
((2S)-2-Methoxy-2-[3-(3-methoxyazetidin-1-yl)phenyl...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1cccc(c1)N1CC(C1)OC
Show InChI InChI=1S/C24H30N8O3S/c1-15-7-8-20(28-27-15)31-10-9-17(12-31)25-23-29-30-24(36-23)26-22(33)21(35-3)16-5-4-6-18(11-16)32-13-19(14-32)34-2/h4-8,11,17,19,21H,9-10,12-14H2,1-3H3,(H,25,29)(H,26,30,33)/t17-,21+/m1/s1
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n/an/a 43.8n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416708
PNG
(2-[3-(3,3-difluoroazetidin-1-yl)phenyl]-N-[5-[[(3R...)
Show SMILES COC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(F)nn2)s1)c1cccc(c1)N1CC(F)(F)C1
Show InChI InChI=1S/C22H23F3N8O2S/c1-35-18(13-3-2-4-15(9-13)33-11-22(24,25)12-33)19(34)27-21-31-30-20(36-21)26-14-7-8-32(10-14)17-6-5-16(23)28-29-17/h2-6,9,14,18H,7-8,10-12H2,1H3,(H,26,30)(H,27,31,34)/t14-,18?/m1/s1
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n/an/a 46.7n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416687
PNG
((2R)-2-(3,5-Dimethoxyphenyl)-2-methoxy-N-[5-[[(3R)...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C21H25N7O4S/c1-30-15-9-13(10-16(11-15)31-2)18(32-3)19(29)24-21-27-26-20(33-21)23-14-6-8-28(12-14)17-5-4-7-22-25-17/h4-5,7,9-11,14,18H,6,8,12H2,1-3H3,(H,23,26)(H,24,27,29)/t14-,18-/m1/s1
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n/an/a 48.2n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416690
PNG
(2-(3,5-dimethoxyphenyl)-2-methoxy-N-[5-[[(3R)-1-py...)
Show SMILES COC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C21H25N7O4S/c1-30-15-9-13(10-16(11-15)31-2)18(32-3)19(29)24-21-27-26-20(33-21)23-14-6-8-28(12-14)17-5-4-7-22-25-17/h4-5,7,9-11,14,18H,6,8,12H2,1-3H3,(H,23,26)(H,24,27,29)/t14-,18?/m1/s1
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n/an/a 48.2n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416690
PNG
(2-(3,5-dimethoxyphenyl)-2-methoxy-N-[5-[[(3R)-1-py...)
Show SMILES COC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C21H25N7O4S/c1-30-15-9-13(10-16(11-15)31-2)18(32-3)19(29)24-21-27-26-20(33-21)23-14-6-8-28(12-14)17-5-4-7-22-25-17/h4-5,7,9-11,14,18H,6,8,12H2,1-3H3,(H,23,26)(H,24,27,29)/t14-,18?/m1/s1
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n/an/a 48.2n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416678
PNG
((2S)-[3-(Difluoromethoxy)phenyl]-2-ethoxy-N-[5-[[(...)
Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C21H23F2N7O3S/c1-2-32-17(13-5-3-6-15(11-13)33-19(22)23)18(31)26-21-29-28-20(34-21)25-14-8-10-30(12-14)16-7-4-9-24-27-16/h3-7,9,11,14,17,19H,2,8,10,12H2,1H3,(H,25,28)(H,26,29,31)/t14-,17+/m1/s1
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n/an/a 50.4n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416696
PNG
(2-[3-(3,3-difluoroazetidin-1-yl)phenyl]-2-ethoxy-N...)
Show SMILES CCOC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)N1CC(F)(F)C1
Show InChI InChI=1S/C23H26F2N8O2S/c1-2-35-19(15-5-3-6-17(11-15)33-13-23(24,25)14-33)20(34)28-22-31-30-21(36-22)27-16-8-10-32(12-16)18-7-4-9-26-29-18/h3-7,9,11,16,19H,2,8,10,12-14H2,1H3,(H,27,30)(H,28,31,34)/t16-,19?/m1/s1
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n/an/a 51.1n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416691
PNG
(2-methoxy-2-[3-(oxetan-3-yl)phenyl]-N-[5-[[(3R)-1-...)
Show SMILES COC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(c1)C1COC1
Show InChI InChI=1S/C21H24N8O3S/c1-31-17(14-4-2-3-13(9-14)15-11-32-12-15)18(30)25-21-28-27-20(33-21)24-16-5-8-29(10-16)19-22-6-7-23-26-19/h2-4,6-7,9,15-17H,5,8,10-12H2,1H3,(H,24,27)(H,25,28,30)/t16-,17?/m1/s1
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n/an/a 52.6n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416661
PNG
((2S)-N-[5-[[(3R)-1-(6-Fluoropyridazin-3-yl)pyrroli...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(F)nn2)s1)c1cccc(c1)N1CC(C1)OC
Show InChI InChI=1S/C23H27FN8O3S/c1-34-17-12-32(13-17)16-5-3-4-14(10-16)20(35-2)21(33)26-23-30-29-22(36-23)25-15-8-9-31(11-15)19-7-6-18(24)27-28-19/h3-7,10,15,17,20H,8-9,11-13H2,1-2H3,(H,25,29)(H,26,30,33)/t15-,20+/m1/s1
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n/an/a 59.1n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416651
PNG
((2R)-2-(3,5-Dimethoxyphenyl)-2-methoxy-N-[5-[[(3R)...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C22H27N7O4S/c1-13-5-6-18(26-25-13)29-8-7-15(12-29)23-21-27-28-22(34-21)24-20(30)19(33-4)14-9-16(31-2)11-17(10-14)32-3/h5-6,9-11,15,19H,7-8,12H2,1-4H3,(H,23,27)(H,24,28,30)/t15-,19-/m1/s1
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n/an/a 59.6n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416685
PNG
((2R)-2-[4-Fluoro-3-(trifluoromethoxy)phenyl]-2-met...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)c(OC(F)(F)F)c1
Show InChI InChI=1S/C20H19F4N7O3S/c1-33-16(11-4-5-13(21)14(9-11)34-20(22,23)24)17(32)27-19-30-29-18(35-19)26-12-6-8-31(10-12)15-3-2-7-25-28-15/h2-5,7,9,12,16H,6,8,10H2,1H3,(H,26,29)(H,27,30,32)/t12-,16-/m1/s1
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n/an/a 64.1n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416657
PNG
((2S)-2-[4-Fluoro-3-(3-fluoroazetidin-1-yl)phenyl]-...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)c(c1)N1CC(F)C1
Show InChI InChI=1S/C22H24F2N8O2S/c1-34-19(13-4-5-16(24)17(9-13)32-10-14(23)11-32)20(33)27-22-30-29-21(35-22)26-15-6-8-31(12-15)18-3-2-7-25-28-18/h2-5,7,9,14-15,19H,6,8,10-12H2,1H3,(H,26,29)(H,27,30,33)/t15-,19+/m1/s1
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n/an/a 64.9n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416688
PNG
((2S)-2-ethoxy-2-[3-(3-methoxyazetidin-1-yl)phenyl]...)
Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)N1CC(C1)OC
Show InChI InChI=1S/C24H30N8O3S/c1-3-35-21(16-6-4-7-18(12-16)32-14-19(15-32)34-2)22(33)27-24-30-29-23(36-24)26-17-9-11-31(13-17)20-8-5-10-25-28-20/h4-8,10,12,17,19,21H,3,9,11,13-15H2,1-2H3,(H,26,29)(H,27,30,33)/t17-,21+/m1/s1
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n/an/a 68.5n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416700
PNG
(2-ethoxy-2-[3-(3-methoxyazetidin-1-yl)phenyl]-N-[5...)
Show SMILES CCOC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)N1CC(C1)OC
Show InChI InChI=1S/C24H30N8O3S/c1-3-35-21(16-6-4-7-18(12-16)32-14-19(15-32)34-2)22(33)27-24-30-29-23(36-24)26-17-9-11-31(13-17)20-8-5-10-25-28-20/h4-8,10,12,17,19,21H,3,9,11,13-15H2,1-2H3,(H,26,29)(H,27,30,33)/t17-,21?/m1/s1
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n/an/a 68.5n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416684
PNG
((2S)-2-[4-Fluoro-3-(trifluoromethoxy)phenyl]-2-met...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)c(OC(F)(F)F)c1
Show InChI InChI=1S/C20H19F4N7O3S/c1-33-16(11-4-5-13(21)14(9-11)34-20(22,23)24)17(32)27-19-30-29-18(35-19)26-12-6-8-31(10-12)15-3-2-7-25-28-15/h2-5,7,9,12,16H,6,8,10H2,1H3,(H,26,29)(H,27,30,32)/t12-,16+/m1/s1
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n/an/a 69.3n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416644
PNG
((2R)-2-Methoxy-2-[3-(3-methoxyazetidin-1-yl)phenyl...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)N1CC(C1)OC
Show InChI InChI=1S/C23H28N8O3S/c1-33-18-13-31(14-18)17-6-3-5-15(11-17)20(34-2)21(32)26-23-29-28-22(35-23)25-16-8-10-30(12-16)19-7-4-9-24-27-19/h3-7,9,11,16,18,20H,8,10,12-14H2,1-2H3,(H,25,28)(H,26,29,32)/t16-,20-/m1/s1
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n/an/a 72.1n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416664
PNG
((2S)-2-[3-(3-Fluoroazetidin-1-yl)-5-methoxy-phenyl...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cc(OC)cc(c1)N1CC(F)C1
Show InChI InChI=1S/C23H27FN8O3S/c1-34-18-9-14(8-17(10-18)32-11-15(24)12-32)20(35-2)21(33)27-23-30-29-22(36-23)26-16-5-7-31(13-16)19-4-3-6-25-28-19/h3-4,6,8-10,15-16,20H,5,7,11-13H2,1-2H3,(H,26,29)(H,27,30,33)/t16-,20-/m1/s1
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n/an/a 72.2n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416639
PNG
((2R)-2-[3-(3-Fluoroazetidin-1-yl)phenyl]-2-methoxy...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)N1CC(F)C1
Show InChI InChI=1S/C22H25FN8O2S/c1-33-19(14-4-2-5-17(10-14)31-11-15(23)12-31)20(32)26-22-29-28-21(34-22)25-16-7-9-30(13-16)18-6-3-8-24-27-18/h2-6,8,10,15-16,19H,7,9,11-13H2,1H3,(H,25,28)(H,26,29,32)/t16-,19-/m1/s1
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n/an/a 72.6n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416670
PNG
((2S)-2-Methoxy-2-[3-(3-methoxyazetidin-1-yl)phenyl...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(c1)N1CC(C1)OC
Show InChI InChI=1S/C22H27N9O3S/c1-33-17-12-31(13-17)16-5-3-4-14(10-16)18(34-2)19(32)26-22-29-28-21(35-22)25-15-6-9-30(11-15)20-23-7-8-24-27-20/h3-5,7-8,10,15,17-18H,6,9,11-13H2,1-2H3,(H,25,28)(H,26,29,32)/t15-,18+/m1/s1
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n/an/a 75.1n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416702
PNG
(2-[3-(3-fluoroazetidin-1-yl)phenyl]-2-methoxy-N-[5...)
Show SMILES COC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1cccc(c1)N1CC(F)C1
Show InChI InChI=1S/C23H27FN8O2S/c1-14-6-7-19(28-27-14)31-9-8-17(13-31)25-22-29-30-23(35-22)26-21(33)20(34-2)15-4-3-5-18(10-15)32-11-16(24)12-32/h3-7,10,16-17,20H,8-9,11-13H2,1-2H3,(H,25,29)(H,26,30,33)/t17-,20?/m1/s1
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n/an/a 77n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416674
PNG
((2S)-2-[3-(3-Fluoroazetidin-1-yl)phenyl]-2-methoxy...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(c1)N1CC(F)C1
Show InChI InChI=1S/C21H24FN9O2S/c1-33-17(13-3-2-4-16(9-13)31-10-14(22)11-31)18(32)26-21-29-28-20(34-21)25-15-5-8-30(12-15)19-23-6-7-24-27-19/h2-4,6-7,9,14-15,17H,5,8,10-12H2,1H3,(H,25,28)(H,26,29,32)/t15-,17+/m1/s1
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n/an/a 77.6n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416641
PNG
((2S)-2-[3-(3,3-Difluoroazetidin-1-yl)phenyl]-2-met...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)N1CC(F)(F)C1
Show InChI InChI=1S/C22H24F2N8O2S/c1-34-18(14-4-2-5-16(10-14)32-12-22(23,24)13-32)19(33)27-21-30-29-20(35-21)26-15-7-9-31(11-15)17-6-3-8-25-28-17/h2-6,8,10,15,18H,7,9,11-13H2,1H3,(H,26,29)(H,27,30,33)/t15-,18+/m1/s1
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n/an/a 87.2n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416672
PNG
((2S)-2-[3-(3,3-Difluoroazetidin-1-yl)phenyl]-2-met...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(c1)N1CC(F)(F)C1
Show InChI InChI=1S/C21H23F2N9O2S/c1-34-16(13-3-2-4-15(9-13)32-11-21(22,23)12-32)17(33)27-20-30-29-19(35-20)26-14-5-8-31(10-14)18-24-6-7-25-28-18/h2-4,6-7,9,14,16H,5,8,10-12H2,1H3,(H,26,29)(H,27,30,33)/t14-,16+/m1/s1
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n/an/a 91.5n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416683
PNG
((2R)-2-Ethoxy-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolid...)
Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H22F3N7O3S/c1-2-33-17(13-5-3-6-15(11-13)34-21(22,23)24)18(32)27-20-30-29-19(35-20)26-14-8-10-31(12-14)16-7-4-9-25-28-16/h3-7,9,11,14,17H,2,8,10,12H2,1H3,(H,26,29)(H,27,30,32)/t14-,17-/m1/s1
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n/an/a 96.1n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416698
PNG
(2-ethoxy-2-[3-(3-fluoroazetidin-1-yl)phenyl]-N-[5-...)
Show SMILES CCOC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)N1CC(F)C1
Show InChI InChI=1S/C23H27FN8O2S/c1-2-34-20(15-5-3-6-18(11-15)32-12-16(24)13-32)21(33)27-23-30-29-22(35-23)26-17-8-10-31(14-17)19-7-4-9-25-28-19/h3-7,9,11,16-17,20H,2,8,10,12-14H2,1H3,(H,26,29)(H,27,30,33)/t17-,20?/m1/s1
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n/an/a 96.8n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416642
PNG
((2R)-2-[3-(3,3-Difluoroazetidin-1-yl)phenyl]-2-met...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)N1CC(F)(F)C1
Show InChI InChI=1S/C22H24F2N8O2S/c1-34-18(14-4-2-5-16(10-14)32-12-22(23,24)13-32)19(33)27-21-30-29-20(35-21)26-15-7-9-31(11-15)17-6-3-8-25-28-17/h2-6,8,10,15,18H,7,9,11-13H2,1H3,(H,26,29)(H,27,30,33)/t15-,18-/m1/s1
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n/an/a 121n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416681
PNG
((2R)-2-Methoxy-2-[3-(oxetan-3-yl)phenyl]-N-[5-[[(3...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)C1COC1
Show InChI InChI=1S/C22H25N7O3S/c1-31-19(15-5-2-4-14(10-15)16-12-32-13-16)20(30)25-22-28-27-21(33-22)24-17-7-9-29(11-17)18-6-3-8-23-26-18/h2-6,8,10,16-17,19H,7,9,11-13H2,1H3,(H,24,27)(H,25,28,30)/t17-,19-/m1/s1
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n/an/a 129n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416706
PNG
(2-[3-(3,3-difluoroazetidin-1-yl)phenyl]-2-methoxy-...)
Show SMILES COC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1cccc(c1)N1CC(F)(F)C1
Show InChI InChI=1S/C23H26F2N8O2S/c1-14-6-7-18(29-28-14)32-9-8-16(11-32)26-21-30-31-22(36-21)27-20(34)19(35-2)15-4-3-5-17(10-15)33-12-23(24,25)13-33/h3-7,10,16,19H,8-9,11-13H2,1-2H3,(H,26,30)(H,27,31,34)/t16-,19?/m1/s1
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n/an/a 130n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416653
PNG
((2R)-3-Methoxy-2-(3-methoxyphenyl)-N-[5-[[(3R)-1-p...)
Show SMILES COC[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC)c1
Show InChI InChI=1S/C21H25N7O3S/c1-30-13-17(14-5-3-6-16(11-14)31-2)19(29)24-21-27-26-20(32-21)23-15-8-10-28(12-15)18-7-4-9-22-25-18/h3-7,9,11,15,17H,8,10,12-13H2,1-2H3,(H,23,26)(H,24,27,29)/t15-,17-/m1/s1
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n/an/a 130n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416689
PNG
((2R)-2-ethoxy-2-[3-(3-methoxyazetidin-1-yl)phenyl]...)
Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)N1CC(C1)OC
Show InChI InChI=1S/C24H30N8O3S/c1-3-35-21(16-6-4-7-18(12-16)32-14-19(15-32)34-2)22(33)27-24-30-29-23(36-24)26-17-9-11-31(13-17)20-8-5-10-25-28-20/h4-8,10,12,17,19,21H,3,9,11,13-15H2,1-2H3,(H,26,29)(H,27,30,33)/t17-,21-/m1/s1
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n/an/a 131n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416700
PNG
(2-ethoxy-2-[3-(3-methoxyazetidin-1-yl)phenyl]-N-[5...)
Show SMILES CCOC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)N1CC(C1)OC
Show InChI InChI=1S/C24H30N8O3S/c1-3-35-21(16-6-4-7-18(12-16)32-14-19(15-32)34-2)22(33)27-24-30-29-23(36-24)26-17-9-11-31(13-17)20-8-5-10-25-28-20/h4-8,10,12,17,19,21H,3,9,11,13-15H2,1-2H3,(H,26,29)(H,27,30,33)/t17-,21?/m1/s1
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n/an/a 131n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416713
PNG
((2R)-3-Methoxy-N-[5-[[(3R)-1-(6-methylpyridazin-3-...)
Show SMILES COC[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1ccccc1
Show InChI InChI=1S/C21H25N7O2S/c1-14-8-9-18(25-24-14)28-11-10-16(12-28)22-20-26-27-21(31-20)23-19(29)17(13-30-2)15-6-4-3-5-7-15/h3-9,16-17H,10-13H2,1-2H3,(H,22,26)(H,23,27,29)/t16-,17-/m1/s1
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n/an/a 146n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416704
PNG
(2-[3-(3,3-difluoroazetidin-1-yl)-4-fluoro-phenyl]-...)
Show SMILES COC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)c(c1)N1CC(F)(F)C1
Show InChI InChI=1S/C22H23F3N8O2S/c1-35-18(13-4-5-15(23)16(9-13)33-11-22(24,25)12-33)19(34)28-21-31-30-20(36-21)27-14-6-8-32(10-14)17-3-2-7-26-29-17/h2-5,7,9,14,18H,6,8,10-12H2,1H3,(H,27,30)(H,28,31,34)/t14-,18?/m1/s1
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n/an/a 147n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416694
PNG
(2-[3-(3-fluoroazetidin-1-yl)phenyl]-N-[5-[[(3R)-1-...)
Show SMILES COC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(F)nn2)s1)c1cccc(c1)N1CC(F)C1
Show InChI InChI=1S/C22H24F2N8O2S/c1-34-19(13-3-2-4-16(9-13)32-10-14(23)11-32)20(33)26-22-30-29-21(35-22)25-15-7-8-31(12-15)18-6-5-17(24)27-28-18/h2-6,9,14-15,19H,7-8,10-12H2,1H3,(H,25,29)(H,26,30,33)/t15-,19?/m1/s1
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n/an/a 149n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416679
PNG
((2R)-[3-(Difluoromethoxy)phenyl]-2-ethoxy-N-[5-[[(...)
Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C21H23F2N7O3S/c1-2-32-17(13-5-3-6-15(11-13)33-19(22)23)18(31)26-21-29-28-20(34-21)25-14-8-10-30(12-14)16-7-4-9-24-27-16/h3-7,9,11,14,17,19H,2,8,10,12H2,1H3,(H,25,28)(H,26,29,31)/t14-,17-/m1/s1
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n/an/a 157n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416698
PNG
(2-ethoxy-2-[3-(3-fluoroazetidin-1-yl)phenyl]-N-[5-...)
Show SMILES CCOC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)N1CC(F)C1
Show InChI InChI=1S/C23H27FN8O2S/c1-2-34-20(15-5-3-6-18(11-15)32-12-16(24)13-32)21(33)27-23-30-29-22(35-23)26-17-8-10-31(14-17)19-7-4-9-25-28-19/h3-7,9,11,16-17,20H,2,8,10,12-14H2,1H3,(H,26,29)(H,27,30,33)/t17-,20?/m1/s1
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n/an/a 188n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416658
PNG
((2R)-2-[4-Fluoro-3-(3-fluoroazetidin-1-yl)phenyl]-...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)c(c1)N1CC(F)C1
Show InChI InChI=1S/C22H24F2N8O2S/c1-34-19(13-4-5-16(24)17(9-13)32-10-14(23)11-32)20(33)27-22-30-29-21(35-22)26-15-6-8-31(12-15)18-3-2-7-25-28-18/h2-5,7,9,14-15,19H,6,8,10-12H2,1H3,(H,26,29)(H,27,30,33)/t15-,19-/m1/s1
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n/an/a 190n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416704
PNG
(2-[3-(3,3-difluoroazetidin-1-yl)-4-fluoro-phenyl]-...)
Show SMILES COC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)c(c1)N1CC(F)(F)C1
Show InChI InChI=1S/C22H23F3N8O2S/c1-35-18(13-4-5-15(23)16(9-13)33-11-22(24,25)12-33)19(34)28-21-31-30-20(36-21)27-14-6-8-32(10-14)17-3-2-7-26-29-17/h2-5,7,9,14,18H,6,8,10-12H2,1H3,(H,27,30)(H,28,31,34)/t14-,18?/m1/s1
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n/an/a 190n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416656
PNG
((2R)-2-[4-Fluoro-3-(3-methoxyazetidin-1-yl)phenyl]...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccc(F)c(c1)N1CC(C1)OC
Show InChI InChI=1S/C23H27FN8O3S/c1-34-16-12-32(13-16)18-10-14(5-6-17(18)24)20(35-2)21(33)27-23-30-29-22(36-23)26-15-7-9-31(11-15)19-4-3-8-25-28-19/h3-6,8,10,15-16,20H,7,9,11-13H2,1-2H3,(H,26,29)(H,27,30,33)/t15-,20-/m1/s1
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n/an/a 192n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416694
PNG
(2-[3-(3-fluoroazetidin-1-yl)phenyl]-N-[5-[[(3R)-1-...)
Show SMILES COC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(F)nn2)s1)c1cccc(c1)N1CC(F)C1
Show InChI InChI=1S/C22H24F2N8O2S/c1-34-19(13-3-2-4-16(9-13)32-10-14(23)11-32)20(33)26-22-30-29-21(35-22)25-15-7-8-31(12-15)18-6-5-17(24)27-28-18/h2-6,9,14-15,19H,7-8,10-12H2,1H3,(H,25,29)(H,26,30,33)/t15-,19?/m1/s1
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n/an/a 195n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416708
PNG
(2-[3-(3,3-difluoroazetidin-1-yl)phenyl]-N-[5-[[(3R...)
Show SMILES COC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(F)nn2)s1)c1cccc(c1)N1CC(F)(F)C1
Show InChI InChI=1S/C22H23F3N8O2S/c1-35-18(13-3-2-4-15(9-13)33-11-22(24,25)12-33)19(34)27-21-31-30-20(36-21)26-14-7-8-32(10-14)17-6-5-16(23)28-29-17/h2-6,9,14,18H,7-8,10-12H2,1H3,(H,26,30)(H,27,31,34)/t14-,18?/m1/s1
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n/an/a 206n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416655
PNG
((2R)-2-(3,5-Dimethoxyphenyl)-2-ethoxy-N-[5-[[(3R)-...)
Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C22H27N7O4S/c1-4-33-19(14-10-16(31-2)12-17(11-14)32-3)20(30)25-22-28-27-21(34-22)24-15-7-9-29(13-15)18-6-5-8-23-26-18/h5-6,8,10-12,15,19H,4,7,9,13H2,1-3H3,(H,24,27)(H,25,28,30)/t15-,19-/m1/s1
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n/an/a 213n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416706
PNG
(2-[3-(3,3-difluoroazetidin-1-yl)phenyl]-2-methoxy-...)
Show SMILES COC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1cccc(c1)N1CC(F)(F)C1
Show InChI InChI=1S/C23H26F2N8O2S/c1-14-6-7-18(29-28-14)32-9-8-16(11-32)26-21-30-31-22(36-21)27-20(34)19(35-2)15-4-3-5-17(10-15)33-12-23(24,25)13-33/h3-7,10,16,19H,8-9,11-13H2,1-2H3,(H,26,30)(H,27,31,34)/t16-,19?/m1/s1
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n/an/a 311n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416663
PNG
((2R)-N-[5-[[(3R)-1-(6-Fluoropyridazin-3-yl)pyrroli...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(F)nn2)s1)c1cccc(c1)N1CC(C1)OC
Show InChI InChI=1S/C23H27FN8O3S/c1-34-17-12-32(13-17)16-5-3-4-14(10-16)20(35-2)21(33)26-23-30-29-22(36-23)25-15-8-9-31(11-15)19-7-6-18(24)27-28-19/h3-7,10,15,17,20H,8-9,11-13H2,1-2H3,(H,25,29)(H,26,30,33)/t15-,20-/m1/s1
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n/an/a 519n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416702
PNG
(2-[3-(3-fluoroazetidin-1-yl)phenyl]-2-methoxy-N-[5...)
Show SMILES COC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1cccc(c1)N1CC(F)C1
Show InChI InChI=1S/C23H27FN8O2S/c1-14-6-7-19(28-27-14)31-9-8-17(13-31)25-22-29-30-23(35-22)26-21(33)20(34-2)15-4-3-5-18(10-15)32-11-16(24)12-32/h3-7,10,16-17,20H,8-9,11-13H2,1-2H3,(H,25,29)(H,26,30,33)/t17-,20?/m1/s1
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n/an/a 612n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416673
PNG
((2R)-2-[3-(3,3-Difluoroazetidin-1-yl)phenyl]-2-met...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(c1)N1CC(F)(F)C1
Show InChI InChI=1S/C21H23F2N9O2S/c1-34-16(13-3-2-4-15(9-13)32-11-21(22,23)12-32)17(33)27-20-30-29-19(35-20)26-14-5-8-31(10-14)18-24-6-7-25-28-18/h2-4,6-7,9,14,16H,5,8,10-12H2,1H3,(H,26,29)(H,27,30,33)/t14-,16-/m1/s1
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n/an/a 660n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416677
PNG
((2R)-2-(3,5-Dimethoxyphenyl)-2-methoxy-N-[5-[[(3R)...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C20H24N8O4S/c1-30-14-8-12(9-15(10-14)31-2)16(32-3)17(29)24-20-27-26-19(33-20)23-13-4-7-28(11-13)18-21-5-6-22-25-18/h5-6,8-10,13,16H,4,7,11H2,1-3H3,(H,23,26)(H,24,27,29)/t13-,16-/m1/s1
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n/an/a 689n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416669
PNG
((2R)-2-Methoxy-2-[3-(3-methoxyazetidin-1-yl)phenyl...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1cccc(c1)N1CC(C1)OC
Show InChI InChI=1S/C24H30N8O3S/c1-15-7-8-20(28-27-15)31-10-9-17(12-31)25-23-29-30-24(36-23)26-22(33)21(35-3)16-5-4-6-18(11-16)32-13-19(14-32)34-2/h4-8,11,17,19,21H,9-10,12-14H2,1-3H3,(H,25,29)(H,26,30,33)/t17-,21-/m1/s1
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n/an/a 971n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416675
PNG
((2R)-2-[3-(3-Fluoroazetidin-1-yl)phenyl]-2-methoxy...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(c1)N1CC(F)C1
Show InChI InChI=1S/C21H24FN9O2S/c1-33-17(13-3-2-4-16(9-13)31-10-14(22)11-31)18(32)26-21-29-28-20(34-21)25-15-5-8-30(12-15)19-23-6-7-24-27-19/h2-4,6-7,9,14-15,17H,5,8,10-12H2,1H3,(H,25,28)(H,26,29,32)/t15-,17-/m1/s1
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n/an/a 1.31E+3n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416696
PNG
(2-[3-(3,3-difluoroazetidin-1-yl)phenyl]-2-ethoxy-N...)
Show SMILES CCOC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1cccc(c1)N1CC(F)(F)C1
Show InChI InChI=1S/C23H26F2N8O2S/c1-2-35-19(15-5-3-6-17(11-15)33-13-23(24,25)14-33)20(34)28-22-31-30-21(36-22)27-16-8-10-32(12-16)18-7-4-9-26-29-18/h3-7,9,11,16,19H,2,8,10,12-14H2,1H3,(H,27,30)(H,28,31,34)/t16-,19?/m1/s1
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n/an/a 1.37E+3n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416671
PNG
((2R)-2-Methoxy-2-[3-(3-methoxyazetidin-1-yl)phenyl...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(c1)N1CC(C1)OC
Show InChI InChI=1S/C22H27N9O3S/c1-33-17-12-31(13-17)16-5-3-4-14(10-16)18(34-2)19(32)26-22-29-28-21(35-22)25-15-6-9-30(11-15)20-23-7-8-24-27-20/h3-5,7-8,10,15,17-18H,6,9,11-13H2,1-2H3,(H,25,28)(H,26,29,32)/t15-,18-/m1/s1
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n/an/a 1.42E+3n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416712
PNG
((2S)-3-Methoxy-N-[5-[[(3R)-1-(6-methylpyridazin-3-...)
Show SMILES COC[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1ccccc1
Show InChI InChI=1S/C21H25N7O2S/c1-14-8-9-18(25-24-14)28-11-10-16(12-28)22-20-26-27-21(31-20)23-19(29)17(13-30-2)15-6-4-3-5-7-15/h3-9,16-17H,10-13H2,1-2H3,(H,22,26)(H,23,27,29)/t16-,17+/m1/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))
BDBM416691
PNG
(2-methoxy-2-[3-(oxetan-3-yl)phenyl]-N-[5-[[(3R)-1-...)
Show SMILES COC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2nccnn2)s1)c1cccc(c1)C1COC1
Show InChI InChI=1S/C21H24N8O3S/c1-31-17(14-4-2-3-13(9-14)15-11-32-12-15)18(30)25-21-28-27-20(33-21)24-16-5-8-29(10-16)19-22-6-7-23-26-19/h2-4,6-7,9,15-17H,5,8,10-12H2,1H3,(H,24,27)(H,25,28,30)/t16-,17?/m1/s1
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n/an/a 1.84E+3n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US10323028 (2019)


BindingDB Entry DOI: 10.7270/Q20R9RTG
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%