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Patent code US10323038

Compile Data Set for Download or QSAR

Found 290 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM399862
PNG
(N-(1-(2-(2-chlorobenzyl)-2,8- diazaspiro[4.5]decan...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CCC2(CCN(Cc3ccccc3Cl)C2)CC1
Show InChI InChI=1S/C22H28ClN5O2/c1-17(29)25(2)19-13-24-28(15-19)21(30)27-11-8-22(9-12-27)7-10-26(16-22)14-18-5-3-4-6-20(18)23/h3-6,13,15H,7-12,14,16H2,1-2H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM399866
PNG
(N-methyl-N-(1-(4-(3-(pyrrolidin-1-yl)-5- (trifluor...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CCN(Cc2cc(cc(c2)C(F)(F)F)N2CCCC2)CC1
Show InChI InChI=1S/C23H29F3N6O2/c1-17(33)28(2)21-14-27-32(16-21)22(34)31-9-7-29(8-10-31)15-18-11-19(23(24,25)26)13-20(12-18)30-5-3-4-6-30/h11-14,16H,3-10,15H2,1-2H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM399875
PNG
(N-methyl-N-(1-(4-((3-methylbiphenyl-4 yl)methyl)pi...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CCN(Cc2ccc(cc2C)-c2ccccc2)CC1
Show InChI InChI=1S/C25H29N5O2/c1-19-15-22(21-7-5-4-6-8-21)9-10-23(19)17-28-11-13-29(14-12-28)25(32)30-18-24(16-26-30)27(3)20(2)31/h4-10,15-16,18H,11-14,17H2,1-3H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM399884
PNG
(N-methyl-N-(1-(4-(2- (trifluoromethyl)benzyl)piper...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CCN(Cc2ccccc2C(F)(F)F)CC1
Show InChI InChI=1S/C19H22F3N5O2/c1-14(28)24(2)16-11-23-27(13-16)18(29)26-9-7-25(8-10-26)12-15-5-3-4-6-17(15)19(20,21)22/h3-6,11,13H,7-10,12H2,1-2H3
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US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM399884
PNG
(N-methyl-N-(1-(4-(2- (trifluoromethyl)benzyl)piper...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CCN(Cc2ccccc2C(F)(F)F)CC1
Show InChI InChI=1S/C19H22F3N5O2/c1-14(28)24(2)16-11-23-27(13-16)18(29)26-9-7-25(8-10-26)12-15-5-3-4-6-17(15)19(20,21)22/h3-6,11,13H,7-10,12H2,1-2H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM399885
PNG
(N-(1-(4-(2-(pyrrolidin-1-yl)-4- (trifluoromethyl)b...)
Show SMILES CC(=O)Nc1cnn(c1)C(=O)N1CCN(Cc2ccc(cc2N2CCCC2)C(F)(F)F)CC1
Show InChI InChI=1S/C22H27F3N6O2/c1-16(32)27-19-13-26-31(15-19)21(33)30-10-8-28(9-11-30)14-17-4-5-18(22(23,24)25)12-20(17)29-6-2-3-7-29/h4-5,12-13,15H,2-3,6-11,14H2,1H3,(H,27,32)
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM399888
PNG
(N-(1-(4-((3-methoxy-[1,1'-biphenyl]-4- yl)methyl)p...)
Show SMILES COc1cc(ccc1CN1CCN(CC1)C(=O)n1cc(NS(C)(=O)=O)cn1)-c1ccccc1
Show InChI InChI=1S/C23H27N5O4S/c1-32-22-14-19(18-6-4-3-5-7-18)8-9-20(22)16-26-10-12-27(13-11-26)23(29)28-17-21(15-24-28)25-33(2,30)31/h3-9,14-15,17,25H,10-13,16H2,1-2H3
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US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM399897
PNG
(N-methyl-N-(1-(2-(3-phenoxybenzyl)- 2,7-diazaspiro...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CCC2(CN(Cc3cccc(Oc4ccccc4)c3)C2)CC1
Show InChI InChI=1S/C27H31N5O3/c1-21(33)29(2)23-16-28-32(18-23)26(34)31-13-11-27(12-14-31)19-30(20-27)17-22-7-6-10-25(15-22)35-24-8-4-3-5-9-24/h3-10,15-16,18H,11-14,17,19-20H2,1-2H3
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US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM399898
PNG
(N-methyl-N-(1-(7-(3-phenoxybenzyl)- 2,7-diazaspiro...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CCC2(CCN(Cc3cccc(Oc4ccccc4)c3)C2)C1
Show InChI InChI=1S/C27H31N5O3/c1-21(33)29(2)23-16-28-32(18-23)26(34)31-14-12-27(20-31)11-13-30(19-27)17-22-7-6-10-25(15-22)35-24-8-4-3-5-9-24/h3-10,15-16,18H,11-14,17,19-20H2,1-2H3
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US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM399900
PNG
(N-methyl-N-(1-(5-(3-(pyridin-2- yloxy)benzyl)octah...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CC2CN(Cc3cccc(Oc4ccccn4)c3)CC2C1
Show InChI InChI=1S/C25H28N6O3/c1-18(32)28(2)22-11-27-31(17-22)25(33)30-15-20-13-29(14-21(20)16-30)12-19-6-5-7-23(10-19)34-24-8-3-4-9-26-24/h3-11,17,20-21H,12-16H2,1-2H3
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US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM399901
PNG
(N-(1-(5-(3- (benzyloxy)benzyl)octahydropyrrolo[3,4...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CC2CN(Cc3cccc(OCc4ccccc4)c3)CC2C1
Show InChI InChI=1S/C27H31N5O3/c1-20(33)29(2)25-12-28-32(18-25)27(34)31-16-23-14-30(15-24(23)17-31)13-22-9-6-10-26(11-22)35-19-21-7-4-3-5-8-21/h3-12,18,23-24H,13-17,19H2,1-2H3
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US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM399903
PNG
(N-methyl-N-(1-(5-(4- phenoxybenzyl)octahydropyrrol...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CC2CN(Cc3ccc(Oc4ccccc4)cc3)CC2C1
Show InChI InChI=1S/C26H29N5O3/c1-19(32)28(2)23-12-27-31(18-23)26(33)30-16-21-14-29(15-22(21)17-30)13-20-8-10-25(11-9-20)34-24-6-4-3-5-7-24/h3-12,18,21-22H,13-17H2,1-2H3
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Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM399904
PNG
(N-(1-(5-((2,2- difluorobenzo[d][1,3]dioxol-5- yl)m...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CC2CN(Cc3ccc4OC(F)(F)Oc4c3)CC2C1
Show InChI InChI=1S/C21H23F2N5O4/c1-13(29)25(2)17-6-24-28(12-17)20(30)27-10-15-8-26(9-16(15)11-27)7-14-3-4-18-19(5-14)32-21(22,23)31-18/h3-6,12,15-16H,7-11H2,1-2H3
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US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM399907
PNG
(N-(1-(5-(4-(4- chlorophenoxy)benzyl)octahydropyrro...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CC2CN(Cc3ccc(Oc4ccc(Cl)cc4)cc3)CC2C1
Show InChI InChI=1S/C26H28ClN5O3/c1-18(33)29(2)23-11-28-32(17-23)26(34)31-15-20-13-30(14-21(20)16-31)12-19-3-7-24(8-4-19)35-25-9-5-22(27)6-10-25/h3-11,17,20-21H,12-16H2,1-2H3
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Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM399909
PNG
(N-(1-(5-(3-chloro-5-(8-oxa-2- azaspiro[4.5]decan-2...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CC2CN(Cc3cc(Cl)cc(c3)N3CCC4(C3)CCOCC4)CC2C1
Show InChI InChI=1S/C28H37ClN6O3/c1-20(36)31(2)26-12-30-35(18-26)27(37)34-16-22-14-32(15-23(22)17-34)13-21-9-24(29)11-25(10-21)33-6-3-28(19-33)4-7-38-8-5-28/h9-12,18,22-23H,3-8,13-17,19H2,1-2H3
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Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM399915
PNG
(N-(1-(2-(5-chloro-2- (trifluoromethyl)benzyl)-2,7-...)
Show SMILES CS(=O)(=O)Nc1cnn(c1)C(=O)N1CCC2(CN(Cc3cc(Cl)ccc3C(F)(F)F)C2)CC1
Show InChI InChI=1S/C20H23ClF3N5O3S/c1-33(31,32)26-16-9-25-29(11-16)18(30)28-6-4-19(5-7-28)12-27(13-19)10-14-8-15(21)2-3-17(14)20(22,23)24/h2-3,8-9,11,26H,4-7,10,12-13H2,1H3
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Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM399788
PNG
(N-(1-(5-(2-chloro-4- morpholinobenzyl)octahydropyr...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CC2CN(Cc3ccc(cc3Cl)N3CCOCC3)CC2C1
Show InChI InChI=1S/C24H31ClN6O3/c1-17(32)27(2)22-10-26-31(16-22)24(33)30-14-19-12-28(13-20(19)15-30)11-18-3-4-21(9-23(18)25)29-5-7-34-8-6-29/h3-4,9-10,16,19-20H,5-8,11-15H2,1-2H3
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Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM399797
PNG
(N-(1-(7-(2-chlorobenzyl)-2,7- diazaspiro[4.4]nonan...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CCC2(CCN(Cc3ccccc3Cl)C2)C1
Show InChI InChI=1S/C21H26ClN5O2/c1-16(28)24(2)18-11-23-27(13-18)20(29)26-10-8-21(15-26)7-9-25(14-21)12-17-5-3-4-6-19(17)22/h3-6,11,13H,7-10,12,14-15H2,1-2H3
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Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM399798
PNG
(N-(1-(7-(2,4-dichlorobenzyl)-2,7- diazaspiro[4.4]n...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CCC2(CCN(Cc3ccc(Cl)cc3Cl)C2)C1
Show InChI InChI=1S/C21H25Cl2N5O2/c1-15(29)25(2)18-10-24-28(12-18)20(30)27-8-6-21(14-27)5-7-26(13-21)11-16-3-4-17(22)9-19(16)23/h3-4,9-10,12H,5-8,11,13-14H2,1-2H3
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Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM399798
PNG
(N-(1-(7-(2,4-dichlorobenzyl)-2,7- diazaspiro[4.4]n...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CCC2(CCN(Cc3ccc(Cl)cc3Cl)C2)C1
Show InChI InChI=1S/C21H25Cl2N5O2/c1-15(29)25(2)18-10-24-28(12-18)20(30)27-8-6-21(14-27)5-7-26(13-21)11-16-3-4-17(22)9-19(16)23/h3-4,9-10,12H,5-8,11,13-14H2,1-2H3
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Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM399816
PNG
(N-methyl-N-(1-(5-(2- (trifluoromethyl)benzyl)octah...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CC2CN(Cc3ccccc3C(F)(F)F)CC2C1
Show InChI InChI=1S/C21H24F3N5O2/c1-14(30)26(2)18-7-25-29(13-18)20(31)28-11-16-9-27(10-17(16)12-28)8-15-5-3-4-6-19(15)21(22,23)24/h3-7,13,16-17H,8-12H2,1-2H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM399831
PNG
(N-methyl-N-(1-(5-(3- (trifluoromethyl)benzyl)octah...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CC2CN(Cc3cccc(c3)C(F)(F)F)CC2C1
Show InChI InChI=1S/C21H24F3N5O2/c1-14(30)26(2)19-7-25-29(13-19)20(31)28-11-16-9-27(10-17(16)12-28)8-15-4-3-5-18(6-15)21(22,23)24/h3-7,13,16-17H,8-12H2,1-2H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM399832
PNG
(N-(1-(5-(3-chloro-5-(tetrahydro-1H- furo[3,4-c]pyr...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CC2CN(Cc3cc(Cl)cc(c3)C3CC4COCC4C3)CC2C1
Show InChI InChI=1S/C27H34ClN5O3/c1-17(34)30(2)26-8-29-33(14-26)27(35)32-12-23-10-31(11-24(23)13-32)9-18-3-19(7-25(28)4-18)20-5-21-15-36-16-22(21)6-20/h3-4,7-8,14,20-24H,5-6,9-13,15-16H2,1-2H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM399848
PNG
(N-(1-(trans-5-((4- chlorobenzyl)(methyl)amino) oct...)
Show SMILES CN(Cc1ccc(Cl)cc1)[C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)n1cc(cn1)N(C)C(C)=O
Show InChI InChI=1S/C22H28ClN5O2/c1-15(29)26(3)21-10-24-28(14-21)22(30)27-12-17-8-20(9-18(17)13-27)25(2)11-16-4-6-19(23)7-5-16/h4-7,10,14,17-18,20H,8-9,11-13H2,1-3H3/t17-,18+,20+
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM399852
PNG
(N-(1-(cis-5-((5-chloro-2- (trifluoromethyl)benzyl)...)
Show SMILES CN(Cc1cc(Cl)ccc1C(F)(F)F)[C@H]1C[C@H]2CN(C[C@H]2C1)C(=O)n1cc(cn1)N(C)C(C)=O
Show InChI InChI=1S/C23H27ClF3N5O2/c1-14(33)30(3)20-9-28-32(13-20)22(34)31-11-15-7-19(8-16(15)12-31)29(2)10-17-6-18(24)4-5-21(17)23(25,26)27/h4-6,9,13,15-16,19H,7-8,10-12H2,1-3H3/t15-,16+,19-
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US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM399852
PNG
(N-(1-(cis-5-((5-chloro-2- (trifluoromethyl)benzyl)...)
Show SMILES CN(Cc1cc(Cl)ccc1C(F)(F)F)[C@H]1C[C@H]2CN(C[C@H]2C1)C(=O)n1cc(cn1)N(C)C(C)=O
Show InChI InChI=1S/C23H27ClF3N5O2/c1-14(33)30(3)20-9-28-32(13-20)22(34)31-11-15-7-19(8-16(15)12-31)29(2)10-17-6-18(24)4-5-21(17)23(25,26)27/h4-6,9,13,15-16,19H,7-8,10-12H2,1-3H3/t15-,16+,19-
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM399872
PNG
(N-(1-(4-(3,4-dichlorobenzyl)piperazine- 1-carbonyl...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CCN(Cc2ccc(Cl)c(Cl)c2)CC1
Show InChI InChI=1S/C18H21Cl2N5O2/c1-13(26)22(2)15-10-21-25(12-15)18(27)24-7-5-23(6-8-24)11-14-3-4-16(19)17(20)9-14/h3-4,9-10,12H,5-8,11H2,1-2H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM399880
PNG
(N-methyl-N-(1-(4-(3- methylbenzyl)piperazine-1-car...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CCN(Cc2cccc(C)c2)CC1
Show InChI InChI=1S/C19H25N5O2/c1-15-5-4-6-17(11-15)13-22-7-9-23(10-8-22)19(26)24-14-18(12-20-24)21(3)16(2)25/h4-6,11-12,14H,7-10,13H2,1-3H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM399882
PNG
(N-methyl-N-(1-(4-(3- (trifluoromethyl)benzyl)piper...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CCN(Cc2cccc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C19H22F3N5O2/c1-14(28)24(2)17-11-23-27(13-17)18(29)26-8-6-25(7-9-26)12-15-4-3-5-16(10-15)19(20,21)22/h3-5,10-11,13H,6-9,12H2,1-2H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM399910
PNG
(N-(1-(5-(4- (benzyloxy)benzyl)octahydropyrrolo[3,4...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CC2CN(Cc3ccc(OCc4ccccc4)cc3)CC2C1
Show InChI InChI=1S/C27H31N5O3/c1-20(33)29(2)25-12-28-32(18-25)27(34)31-16-23-14-30(15-24(23)17-31)13-21-8-10-26(11-9-21)35-19-22-6-4-3-5-7-22/h3-12,18,23-24H,13-17,19H2,1-2H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM399795
PNG
(N-methyl-N-(1-(2-(2- (trifluoromethyl)benzyl)-2,7-...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CCC2(CN(Cc3ccccc3C(F)(F)F)C2)CC1
Show InChI InChI=1S/C22H26F3N5O2/c1-16(31)27(2)18-11-26-30(13-18)20(32)29-9-7-21(8-10-29)14-28(15-21)12-17-5-3-4-6-19(17)22(23,24)25/h3-6,11,13H,7-10,12,14-15H2,1-2H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM399800
PNG
(N-(1-(7-(2-chloro-4-methylbenzyl)-2,7- diazaspiro[...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CCC2(CCN(Cc3ccc(C)cc3Cl)C2)C1
Show InChI InChI=1S/C22H28ClN5O2/c1-16-4-5-18(20(23)10-16)12-26-8-6-22(14-26)7-9-27(15-22)21(30)28-13-19(11-24-28)25(3)17(2)29/h4-5,10-11,13H,6-9,12,14-15H2,1-3H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM399805
PNG
(N-methyl-N-(1-(7-(3- (trifluoromethyl)benzyl)-2,7-...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CCC2(CCN(Cc3cccc(c3)C(F)(F)F)C2)C1
Show InChI InChI=1S/C22H26F3N5O2/c1-16(31)27(2)19-11-26-30(13-19)20(32)29-9-7-21(15-29)6-8-28(14-21)12-17-4-3-5-18(10-17)22(23,24)25/h3-5,10-11,13H,6-9,12,14-15H2,1-2H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM399817
PNG
(N-(1-(5-(4-chloro-3- (trifluoromethyl)benzyl)octah...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CC2CN(Cc3ccc(Cl)c(c3)C(F)(F)F)CC2C1
Show InChI InChI=1S/C21H23ClF3N5O2/c1-13(31)27(2)17-6-26-30(12-17)20(32)29-10-15-8-28(9-16(15)11-29)7-14-3-4-19(22)18(5-14)21(23,24)25/h3-6,12,15-16H,7-11H2,1-2H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM399824
PNG
(N-(1-(5-(3-chloro-5-(pyrrolidin-1- yl)benzyl)octah...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CC2CN(Cc3cc(Cl)cc(c3)N3CCCC3)CC2C1
Show InChI InChI=1S/C24H31ClN6O2/c1-17(32)27(2)23-10-26-31(16-23)24(33)30-14-19-12-28(13-20(19)15-30)11-18-7-21(25)9-22(8-18)29-5-3-4-6-29/h7-10,16,19-20H,3-6,11-15H2,1-2H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM399824
PNG
(N-(1-(5-(3-chloro-5-(pyrrolidin-1- yl)benzyl)octah...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CC2CN(Cc3cc(Cl)cc(c3)N3CCCC3)CC2C1
Show InChI InChI=1S/C24H31ClN6O2/c1-17(32)27(2)23-10-26-31(16-23)24(33)30-14-19-12-28(13-20(19)15-30)11-18-7-21(25)9-22(8-18)29-5-3-4-6-29/h7-10,16,19-20H,3-6,11-15H2,1-2H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM399825
PNG
(N-(1-(5-(2,6- dichlorobenzyl)octahydropyrrolo[3,4-...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CC2CN(Cc3c(Cl)cccc3Cl)CC2C1
Show InChI InChI=1S/C20H23Cl2N5O2/c1-13(28)24(2)16-6-23-27(11-16)20(29)26-9-14-7-25(8-15(14)10-26)12-17-18(21)4-3-5-19(17)22/h3-6,11,14-15H,7-10,12H2,1-2H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM399875
PNG
(N-methyl-N-(1-(4-((3-methylbiphenyl-4 yl)methyl)pi...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CCN(Cc2ccc(cc2C)-c2ccccc2)CC1
Show InChI InChI=1S/C25H29N5O2/c1-19-15-22(21-7-5-4-6-8-21)9-10-23(19)17-28-11-13-29(14-12-28)25(32)30-18-24(16-26-30)27(3)20(2)31/h4-10,15-16,18H,11-14,17H2,1-3H3
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US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM399882
PNG
(N-methyl-N-(1-(4-(3- (trifluoromethyl)benzyl)piper...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CCN(Cc2cccc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C19H22F3N5O2/c1-14(28)24(2)17-11-23-27(13-17)18(29)26-8-6-25(7-9-26)12-15-4-3-5-16(10-15)19(20,21)22/h3-5,10-11,13H,6-9,12H2,1-2H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM399890
PNG
(N-methyl-N-(1-(5-((3-methyl-[1,1'- biphenyl]-4- yl...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CC2CN(Cc3ccc(cc3C)-c3ccccc3)CC2C1
Show InChI InChI=1S/C27H31N5O2/c1-19-11-22(21-7-5-4-6-8-21)9-10-23(19)13-30-14-24-16-31(17-25(24)15-30)27(34)32-18-26(12-28-32)29(3)20(2)33/h4-12,18,24-25H,13-17H2,1-3H3
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ABIDE THERAPEUTICS, INC.

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Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM399891
PNG
(N-methyl-N-(1-(2-((3-methyl-[1,1- biphenyl]-4-yl)m...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CCC2(CN(Cc3ccc(cc3C)-c3ccccc3)C2)CC1
Show InChI InChI=1S/C28H33N5O2/c1-21-15-24(23-7-5-4-6-8-23)9-10-25(21)17-31-19-28(20-31)11-13-32(14-12-28)27(35)33-18-26(16-29-33)30(3)22(2)34/h4-10,15-16,18H,11-14,17,19-20H2,1-3H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM399906
PNG
(N-(1-(5-(3-(3- chlorophenoxy)benzyl)octahydropyrro...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CC2CN(Cc3cccc(Oc4cccc(Cl)c4)c3)CC2C1
Show InChI InChI=1S/C26H28ClN5O3/c1-18(33)29(2)23-11-28-32(17-23)26(34)31-15-20-13-30(14-21(20)16-31)12-19-5-3-7-24(9-19)35-25-8-4-6-22(27)10-25/h3-11,17,20-21H,12-16H2,1-2H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM399908
PNG
(N-methyl-N-(1-(5-(2,4,5- trifluorobenzyl)octahydro...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CC2CN(Cc3cc(F)c(F)cc3F)CC2C1
Show InChI InChI=1S/C20H22F3N5O2/c1-12(29)25(2)16-5-24-28(11-16)20(30)27-9-14-7-26(8-15(14)10-27)6-13-3-18(22)19(23)4-17(13)21/h3-5,11,14-15H,6-10H2,1-2H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM399912
PNG
(N-(1-(7-(2-chloro-4-(pyrimidin-4- yl)benzyl)-2,7-d...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CCC2(CCN(Cc3ccc(cc3Cl)-c3ccncn3)C2)C1
Show InChI InChI=1S/C25H28ClN7O2/c1-18(34)30(2)21-12-29-33(14-21)24(35)32-10-7-25(16-32)6-9-31(15-25)13-20-4-3-19(11-22(20)26)23-5-8-27-17-28-23/h3-5,8,11-12,14,17H,6-7,9-10,13,15-16H2,1-2H3
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n/an/a<100n/an/an/an/an/an/a



ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM399915
PNG
(N-(1-(2-(5-chloro-2- (trifluoromethyl)benzyl)-2,7-...)
Show SMILES CS(=O)(=O)Nc1cnn(c1)C(=O)N1CCC2(CN(Cc3cc(Cl)ccc3C(F)(F)F)C2)CC1
Show InChI InChI=1S/C20H23ClF3N5O3S/c1-33(31,32)26-16-9-25-29(11-16)18(30)28-6-4-19(5-7-28)12-27(13-19)10-14-8-15(21)2-3-17(14)20(22,23)24/h2-3,8-9,11,26H,4-7,10,12-13H2,1H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM399918
PNG
(N-(1-(4-(5-chloro-2- (trifluoromethyl)benzyl)piper...)
Show SMILES CS(=O)(=O)Nc1cnn(c1)C(=O)N1CCN(Cc2cc(Cl)ccc2C(F)(F)F)CC1
Show InChI InChI=1S/C17H19ClF3N5O3S/c1-30(28,29)23-14-9-22-26(11-14)16(27)25-6-4-24(5-7-25)10-12-8-13(18)2-3-15(12)17(19,20)21/h2-3,8-9,11,23H,4-7,10H2,1H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM399920
PNG
(N-(1-(4-(4-(oxazol-2-yl)-2- (trifluoromethyl)benzy...)
Show SMILES CS(=O)(=O)Nc1cnn(c1)C(=O)N1CCN(Cc2ccc(cc2C(F)(F)F)-c2ncco2)CC1
Show InChI InChI=1S/C20H21F3N6O4S/c1-34(31,32)26-16-11-25-29(13-16)19(30)28-7-5-27(6-8-28)12-15-3-2-14(18-24-4-9-33-18)10-17(15)20(21,22)23/h2-4,9-11,13,26H,5-8,12H2,1H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM399840
PNG
(N-methyl-N-(1-(5-(4-morpholino-2- (trifluoromethyl...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CC2CN(Cc3ccc(cc3C(F)(F)F)N3CCOCC3)CC2C1
Show InChI InChI=1S/C25H31F3N6O3/c1-17(35)30(2)22-10-29-34(16-22)24(36)33-14-19-12-31(13-20(19)15-33)11-18-3-4-21(9-23(18)25(26,27)28)32-5-7-37-8-6-32/h3-4,9-10,16,19-20H,5-8,11-15H2,1-2H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Mus musculus (mouse))
BDBM399877
PNG
(N-(1-(4-(2-chloro-4- morpholinobenzyl)piperazine-1...)
Show SMILES CN(C(C)=O)c1cnn(c1)C(=O)N1CCN(Cc2ccc(cc2Cl)N2CCOCC2)CC1
Show InChI InChI=1S/C22H29ClN6O3/c1-17(30)25(2)20-14-24-29(16-20)22(31)28-7-5-26(6-8-28)15-18-3-4-19(13-21(18)23)27-9-11-32-12-10-27/h3-4,13-14,16H,5-12,15H2,1-2H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Mus musculus (mouse))
BDBM399889
PNG
(N-(1-(4-((3-chloro-[1,1'-biphenyl]-4- yl)methyl)pi...)
Show SMILES CS(=O)(=O)Nc1cnn(c1)C(=O)N1CCN(Cc2ccc(cc2Cl)-c2ccccc2)CC1
Show InChI InChI=1S/C22H24ClN5O3S/c1-32(30,31)25-20-14-24-28(16-20)22(29)27-11-9-26(10-12-27)15-19-8-7-18(13-21(19)23)17-5-3-2-4-6-17/h2-8,13-14,16,25H,9-12,15H2,1H3
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ABIDE THERAPEUTICS, INC.

US Patent


Assay Description
Proteomes (mouse brain membrane fraction or cell lysates for mouse assays; human prefrontal cortex or cell membrane fractions for human assays) (50 &...


US Patent US10323038 (2019)

More data for this
Ligand-Target Pair
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