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Patent code US10323042

Compile Data Set for Download or QSAR

Found 246 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))		BDBM399979
PNG
(US10323042, Example 58)
Show SMILES Fc1cc(-c2c3OCC(F)(F)Cn3nc2C(=O)NC2CC2)c(F)cc1Cl
Show InChI InChI=1S/C16H12ClF4N3O2/c17-9-4-10(18)8(3-11(9)19)12-13(14(25)22-7-1-2-7)23-24-5-16(20,21)6-26-15(12)24/h3-4,7H,1-2,5-6H2,(H,22,25)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))		BDBM399978
PNG
(US10323042, Example 57)
Show SMILES Cc1cc(Cl)c(F)cc1-c1c(nn2C[C@H](F)COc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H16ClF2N3O2/c1-8-4-12(18)13(20)5-11(8)14-15(16(24)21-10-2-3-10)22-23-6-9(19)7-25-17(14)23/h4-5,9-10H,2-3,6-7H2,1H3,(H,21,24)/t9-/m0/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.86n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))		BDBM399927
PNG
((6S)-3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropyl...)
Show SMILES F[C@@H]1COc2c(c(nn2C1)C(=O)NC1CC1)-c1cc(F)c(Cl)cc1F
Show InChI InChI=1S/C16H13ClF3N3O2/c17-10-4-11(19)9(3-12(10)20)13-14(15(24)21-8-1-2-8)22-23-5-7(18)6-25-16(13)23/h3-4,7-8H,1-2,5-6H2,(H,21,24)/t7-/m0/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))		BDBM399928
PNG
(3-(4-Chloro-2-methylphenyl)-N-cyclopropyl-6,6-difl...)
Show SMILES Cc1cc(Cl)ccc1-c1c2OCC(F)(F)Cn2nc1C(=O)NC1CC1
Show InChI InChI=1S/C17H16ClF2N3O2/c1-9-6-10(18)2-5-12(9)13-14(15(24)21-11-3-4-11)22-23-7-17(19,20)8-25-16(13)23/h2,5-6,11H,3-4,7-8H2,1H3,(H,21,24)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.29n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))		BDBM399973
PNG
(US10323042, Example 53A | US10323042, Example 53B)
Show SMILES Cc1cc(C#N)c(F)cc1-c1c(nn2C[C@H](F)COc12)C(=O)NC1CC1
Show InChI InChI=1S/C18H16F2N4O2/c1-9-4-10(6-21)14(20)5-13(9)15-16(17(25)22-12-2-3-12)23-24-7-11(19)8-26-18(15)24/h4-5,11-12H,2-3,7-8H2,1H3,(H,22,25)/t11-/m0/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.35n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM399978
PNG
(US10323042, Example 57)
Show SMILES Cc1cc(Cl)c(F)cc1-c1c(nn2C[C@H](F)COc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H16ClF2N3O2/c1-8-4-12(18)13(20)5-11(8)14-15(16(24)21-10-2-3-10)22-23-6-9(19)7-25-17(14)23/h4-5,9-10H,2-3,6-7H2,1H3,(H,21,24)/t9-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.66n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))		BDBM399973
PNG
(US10323042, Example 53A | US10323042, Example 53B)
Show SMILES Cc1cc(C#N)c(F)cc1-c1c(nn2C[C@H](F)COc12)C(=O)NC1CC1
Show InChI InChI=1S/C18H16F2N4O2/c1-9-4-10(6-21)14(20)5-13(9)15-16(17(25)22-12-2-3-12)23-24-7-11(19)8-26-18(15)24/h4-5,11-12H,2-3,7-8H2,1H3,(H,22,25)/t11-/m0/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.45n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM399927
PNG
((6S)-3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropyl...)
Show SMILES F[C@@H]1COc2c(c(nn2C1)C(=O)NC1CC1)-c1cc(F)c(Cl)cc1F
Show InChI InChI=1S/C16H13ClF3N3O2/c17-10-4-11(19)9(3-12(10)20)13-14(15(24)21-8-1-2-8)22-23-5-7(18)6-25-16(13)23/h3-4,7-8H,1-2,5-6H2,(H,21,24)/t7-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.51n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM399979
PNG
(US10323042, Example 58)
Show SMILES Fc1cc(-c2c3OCC(F)(F)Cn3nc2C(=O)NC2CC2)c(F)cc1Cl
Show InChI InChI=1S/C16H12ClF4N3O2/c17-9-4-10(18)8(3-11(9)19)12-13(14(25)22-7-1-2-7)23-24-5-16(20,21)6-26-15(12)24/h3-4,7H,1-2,5-6H2,(H,22,25)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8.52n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM399973
PNG
(US10323042, Example 53A | US10323042, Example 53B)
Show SMILES Cc1cc(C#N)c(F)cc1-c1c(nn2C[C@H](F)COc12)C(=O)NC1CC1
Show InChI InChI=1S/C18H16F2N4O2/c1-9-4-10(6-21)14(20)5-13(9)15-16(17(25)22-12-2-3-12)23-24-7-11(19)8-26-18(15)24/h4-5,11-12H,2-3,7-8H2,1H3,(H,22,25)/t11-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10.6n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))		BDBM399937
PNG
(US10323042, Example 17)
Show SMILES Cc1cc(Cl)c(F)cc1-c1c2OCCCn2nc1C(=O)NC1CC1
Show InChI InChI=1S/C17H17ClFN3O2/c1-9-7-12(18)13(19)8-11(9)14-15(16(23)20-10-3-4-10)21-22-5-2-6-24-17(14)22/h7-8,10H,2-6H2,1H3,(H,20,23)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 11n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))		BDBM399971
PNG
(US10323042, Example 51)
Show SMILES Cc1cc(C#N)c(F)cc1-c1c(nn2CC(F)COc12)C(=O)NC1CC1
Show InChI InChI=1S/C18H16F2N4O2/c1-9-4-10(6-21)14(20)5-13(9)15-16(17(25)22-12-2-3-12)23-24-7-11(19)8-26-18(15)24/h4-5,11-12H,2-3,7-8H2,1H3,(H,22,25)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 12n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))		BDBM399968
PNG
(US10323042, Example 48)
Show SMILES Cc1cc(Cl)c(F)cc1-c1c2OCCCn2nc1C(=O)N1CCC1
Show InChI InChI=1S/C17H17ClFN3O2/c1-10-8-12(18)13(19)9-11(10)14-15(16(23)21-4-2-5-21)20-22-6-3-7-24-17(14)22/h8-9H,2-7H2,1H3
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 12.1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))		BDBM399969
PNG
(US10323042, Example 49)
Show SMILES Fc1cc(cc(F)c1Cl)-c1c2OCCCn2nc1C(=O)N1CCC1
Show InChI InChI=1S/C16H14ClF2N3O2/c17-13-10(18)7-9(8-11(13)19)12-14(15(23)21-3-1-4-21)20-22-5-2-6-24-16(12)22/h7-8H,1-6H2
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 13.3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))		BDBM399926
PNG
((6S)-3-(4-Chloro-2-methylphenyl)-N-cyclopropyl-6-f...)
Show SMILES Cc1cc(Cl)ccc1-c1c(nn2C[C@H](F)COc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H17ClFN3O2/c1-9-6-10(18)2-5-13(9)14-15(16(23)20-12-3-4-12)21-22-7-11(19)8-24-17(14)22/h2,5-6,11-12H,3-4,7-8H2,1H3,(H,20,23)/t11-/m0/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 14.4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))		BDBM399967
PNG
(US10323042, Example 47)
Show SMILES Fc1cc(cc(F)c1Cl)-c1c2OCCCn2nc1C(=O)NC1CC1
Show InChI InChI=1S/C16H14ClF2N3O2/c17-13-10(18)6-8(7-11(13)19)12-14(15(23)20-9-2-3-9)21-22-4-1-5-24-16(12)22/h6-7,9H,1-5H2,(H,20,23)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 15.7n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (Human))		BDBM399979
PNG
(US10323042, Example 58)
Show SMILES Fc1cc(-c2c3OCC(F)(F)Cn3nc2C(=O)NC2CC2)c(F)cc1Cl
Show InChI InChI=1S/C16H12ClF4N3O2/c17-9-4-10(18)8(3-11(9)19)12-13(14(25)22-7-1-2-7)23-24-5-16(20,21)6-26-15(12)24/h3-4,7H,1-2,5-6H2,(H,22,25)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 16.4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))		BDBM399960
PNG
(US10323042, Example 40)
Show SMILES FC1COc2c(c(nn2C1)C(=O)NC1CC1)-c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C16H14ClF2N3O2/c17-11-4-1-8(5-12(11)19)13-14(15(23)20-10-2-3-10)21-22-6-9(18)7-24-16(13)22/h1,4-5,9-10H,2-3,6-7H2,(H,20,23)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 19.7n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))		BDBM399964
PNG
(US10323042, Example 44)
Show SMILES Cc1cc(Cl)ccc1-c1c(nn2CC(F)COc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H17ClFN3O2/c1-9-6-10(18)2-5-13(9)14-15(16(23)20-12-3-4-12)21-22-7-11(19)8-24-17(14)22/h2,5-6,11-12H,3-4,7-8H2,1H3,(H,20,23)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 20.6n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM399937
PNG
(US10323042, Example 17)
Show SMILES Cc1cc(Cl)c(F)cc1-c1c2OCCCn2nc1C(=O)NC1CC1
Show InChI InChI=1S/C17H17ClFN3O2/c1-9-7-12(18)13(19)8-11(9)14-15(16(23)20-10-3-4-10)21-22-5-2-6-24-17(14)22/h7-8,10H,2-6H2,1H3,(H,20,23)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 21.3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))		BDBM399938
PNG
(US10323042, Example 18)
Show SMILES Cc1cc(C#N)c(F)cc1-c1c2OCCCn2nc1C(=O)N1CCC1
Show InChI InChI=1S/C18H17FN4O2/c1-11-8-12(10-20)14(19)9-13(11)15-16(17(24)22-4-2-5-22)21-23-6-3-7-25-18(15)23/h8-9H,2-7H2,1H3
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 23.8n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))		BDBM399975
PNG
(US10323042, Example 54)
Show SMILES F[C@@H]1COc2c(c(nn2C1)C(=O)NC1CC1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C16H15ClFN3O2/c17-10-3-1-9(2-4-10)13-14(15(22)19-12-5-6-12)20-21-7-11(18)8-23-16(13)21/h1-4,11-12H,5-8H2,(H,19,22)/t11-/m0/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 25.3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))		BDBM399958
PNG
(US10323042, Example 38)
Show SMILES CCNC(=O)c1nn2CCCOc2c1-c1cc(F)c(Cl)cc1C
Show InChI InChI=1S/C16H17ClFN3O2/c1-3-19-15(22)14-13(16-21(20-14)5-4-6-23-16)10-8-12(18)11(17)7-9(10)2/h7-8H,3-6H2,1-2H3,(H,19,22)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 26.2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM399971
PNG
(US10323042, Example 51)
Show SMILES Cc1cc(C#N)c(F)cc1-c1c(nn2CC(F)COc12)C(=O)NC1CC1
Show InChI InChI=1S/C18H16F2N4O2/c1-9-4-10(6-21)14(20)5-13(9)15-16(17(25)22-12-2-3-12)23-24-7-11(19)8-26-18(15)24/h4-5,11-12H,2-3,7-8H2,1H3,(H,22,25)
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n/an/a 26.7n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM399923
PNG
(Azetidin-1-yl[3-(4-chloro-2,5-difluorophenyl)-6,7-...)
Show SMILES Fc1cc(-c2c3OCCCn3nc2C(=O)N2CCC2)c(F)cc1Cl
Show InChI InChI=1S/C16H14ClF2N3O2/c17-10-8-11(18)9(7-12(10)19)13-14(15(23)21-3-1-4-21)20-22-5-2-6-24-16(13)22/h7-8H,1-6H2
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n/an/a 27.6n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM399928
PNG
(3-(4-Chloro-2-methylphenyl)-N-cyclopropyl-6,6-difl...)
Show SMILES Cc1cc(Cl)ccc1-c1c2OCC(F)(F)Cn2nc1C(=O)NC1CC1
Show InChI InChI=1S/C17H16ClF2N3O2/c1-9-6-10(18)2-5-12(9)13-14(15(24)21-11-3-4-11)22-23-7-17(19,20)8-25-16(13)23/h2,5-6,11H,3-4,7-8H2,1H3,(H,21,24)
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n/an/a 28.2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (Human))		BDBM399978
PNG
(US10323042, Example 57)
Show SMILES Cc1cc(Cl)c(F)cc1-c1c(nn2C[C@H](F)COc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H16ClF2N3O2/c1-8-4-12(18)13(20)5-11(8)14-15(16(24)21-10-2-3-10)22-23-6-9(19)7-25-17(14)23/h4-5,9-10H,2-3,6-7H2,1H3,(H,21,24)/t9-/m0/s1
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n/an/a 28.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM399973
PNG
(US10323042, Example 53A | US10323042, Example 53B)
Show SMILES Cc1cc(C#N)c(F)cc1-c1c(nn2C[C@H](F)COc12)C(=O)NC1CC1
Show InChI InChI=1S/C18H16F2N4O2/c1-9-4-10(6-21)14(20)5-13(9)15-16(17(25)22-12-2-3-12)23-24-7-11(19)8-26-18(15)24/h4-5,11-12H,2-3,7-8H2,1H3,(H,22,25)/t11-/m0/s1
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n/an/a 29.2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (Human))		BDBM399927
PNG
((6S)-3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropyl...)
Show SMILES F[C@@H]1COc2c(c(nn2C1)C(=O)NC1CC1)-c1cc(F)c(Cl)cc1F
Show InChI InChI=1S/C16H13ClF3N3O2/c17-10-4-11(19)9(3-12(10)20)13-14(15(24)21-8-1-2-8)22-23-5-7(18)6-25-16(13)23/h3-4,7-8H,1-2,5-6H2,(H,21,24)/t7-/m0/s1
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n/an/a 31.4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))		BDBM399923
PNG
(Azetidin-1-yl[3-(4-chloro-2,5-difluorophenyl)-6,7-...)
Show SMILES Fc1cc(-c2c3OCCCn3nc2C(=O)N2CCC2)c(F)cc1Cl
Show InChI InChI=1S/C16H14ClF2N3O2/c17-10-8-11(18)9(7-12(10)19)13-14(15(23)21-3-1-4-21)20-22-5-2-6-24-16(13)22/h7-8H,1-6H2
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n/an/a 31.9n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))		BDBM399939
PNG
(US10323042, Example 19)
Show SMILES FC1(F)COc2c(c(nn2C1)C(=O)NC1CC1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C16H14ClF2N3O2/c17-10-3-1-9(2-4-10)12-13(14(23)20-11-5-6-11)21-22-7-16(18,19)8-24-15(12)22/h1-4,11H,5-8H2,(H,20,23)
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Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))		BDBM399925
PNG
(3-(4-Cyano-5-fluoro-2-methylphenyl)-N-cyclopropyl-...)
Show SMILES Cc1cc(C#N)c(F)cc1-c1c(nn2CCCOc12)C(=O)NC1CC1
Show InChI InChI=1S/C18H17FN4O2/c1-10-7-11(9-20)14(19)8-13(10)15-16(17(24)21-12-3-4-12)22-23-5-2-6-25-18(15)23/h7-8,12H,2-6H2,1H3,(H,21,24)
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Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))		BDBM399936
PNG
(US10323042, Example 16)
Show SMILES Fc1cc(-c2c3OCCCn3nc2C(=O)NC2CC2)c(F)cc1Cl
Show InChI InChI=1S/C16H14ClF2N3O2/c17-10-7-11(18)9(6-12(10)19)13-14(15(23)20-8-2-3-8)21-22-4-1-5-24-16(13)22/h6-8H,1-5H2,(H,20,23)
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n/an/a 36.7n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM399934
PNG
(US10323042, Example 14)
Show SMILES Clc1ccc(cc1Cl)-c1c(nn2CCCOc12)C(=O)N1CCC1
Show InChI InChI=1S/C16H15Cl2N3O2/c17-11-4-3-10(9-12(11)18)13-14(15(22)20-5-1-6-20)19-21-7-2-8-23-16(13)21/h3-4,9H,1-2,5-8H2
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n/an/a 37.1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))		BDBM399963
PNG
(US10323042, Example 43)
Show SMILES FC1COc2c(c(nn2C1)C(=O)NC1CC1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C16H15ClFN3O2/c17-10-3-1-9(2-4-10)13-14(15(22)19-12-5-6-12)20-21-7-11(18)8-23-16(13)21/h1-4,11-12H,5-8H2,(H,19,22)
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n/an/a 38n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))		BDBM399970
PNG
(US10323042, Example 50)
Show SMILES Fc1cc(-c2c3OCCCn3nc2C(=O)N2CCC2)c(F)cc1C#N
Show InChI InChI=1S/C17H14F2N4O2/c18-12-8-11(13(19)7-10(12)9-20)14-15(16(24)22-3-1-4-22)21-23-5-2-6-25-17(14)23/h7-8H,1-6H2
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n/an/a 40.8n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM399938
PNG
(US10323042, Example 18)
Show SMILES Cc1cc(C#N)c(F)cc1-c1c2OCCCn2nc1C(=O)N1CCC1
Show InChI InChI=1S/C18H17FN4O2/c1-11-8-12(10-20)14(19)9-13(11)15-16(17(24)22-4-2-5-22)21-23-6-3-7-25-18(15)23/h8-9H,2-7H2,1H3
PDB

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n/an/a 40.9n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))		BDBM399959
PNG
(US10323042, Example 39)
Show SMILES CCNC(=O)c1nn2CCCOc2c1-c1cc(F)c(Cl)cc1F
Show InChI InChI=1S/C15H14ClF2N3O2/c1-2-19-14(22)13-12(15-21(20-13)4-3-5-23-15)8-6-11(18)9(16)7-10(8)17/h6-7H,2-5H2,1H3,(H,19,22)
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Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM399926
PNG
((6S)-3-(4-Chloro-2-methylphenyl)-N-cyclopropyl-6-f...)
Show SMILES Cc1cc(Cl)ccc1-c1c(nn2C[C@H](F)COc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H17ClFN3O2/c1-9-6-10(18)2-5-13(9)14-15(16(23)20-12-3-4-12)21-22-7-11(19)8-24-17(14)22/h2,5-6,11-12H,3-4,7-8H2,1H3,(H,20,23)/t11-/m0/s1
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n/an/a 44.3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (Human))		BDBM399967
PNG
(US10323042, Example 47)
Show SMILES Fc1cc(cc(F)c1Cl)-c1c2OCCCn2nc1C(=O)NC1CC1
Show InChI InChI=1S/C16H14ClF2N3O2/c17-13-10(18)6-8(7-11(13)19)12-14(15(23)20-9-2-3-9)21-22-4-1-5-24-16(12)22/h6-7,9H,1-5H2,(H,20,23)
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n/an/a 45.8n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM399936
PNG
(US10323042, Example 16)
Show SMILES Fc1cc(-c2c3OCCCn3nc2C(=O)NC2CC2)c(F)cc1Cl
Show InChI InChI=1S/C16H14ClF2N3O2/c17-10-7-11(18)9(6-12(10)19)13-14(15(23)20-8-2-3-8)21-22-4-1-5-24-16(13)22/h6-8H,1-5H2,(H,20,23)
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n/an/a 46n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (Human))		BDBM399952
PNG
(US10323042, Example 32)
Show SMILES Clc1cccc(c1)-c1c(nn2CCCOc12)C(=O)N1CCC1
Show InChI InChI=1S/C16H16ClN3O2/c17-12-5-1-4-11(10-12)13-14(15(21)19-6-2-7-19)18-20-8-3-9-22-16(13)20/h1,4-5,10H,2-3,6-9H2
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Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))		BDBM399933
PNG
(US10323042, Example 13)
Show SMILES Fc1cc(ccc1Cl)-c1c2OCCCn2nc1C(=O)NC1CC1
Show InChI InChI=1S/C16H15ClFN3O2/c17-11-5-2-9(8-12(11)18)13-14(15(22)19-10-3-4-10)20-21-6-1-7-23-16(13)21/h2,5,8,10H,1,3-4,6-7H2,(H,19,22)
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Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM399960
PNG
(US10323042, Example 40)
Show SMILES FC1COc2c(c(nn2C1)C(=O)NC1CC1)-c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C16H14ClF2N3O2/c17-11-4-1-8(5-12(11)19)13-14(15(23)20-10-2-3-10)21-22-6-9(18)7-24-16(13)22/h1,4-5,9-10H,2-3,6-7H2,(H,20,23)
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Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM399964
PNG
(US10323042, Example 44)
Show SMILES Cc1cc(Cl)ccc1-c1c(nn2CC(F)COc12)C(=O)NC1CC1
Show InChI InChI=1S/C17H17ClFN3O2/c1-9-6-10(18)2-5-13(9)14-15(16(23)20-12-3-4-12)21-22-7-11(19)8-24-17(14)22/h2,5-6,11-12H,3-4,7-8H2,1H3,(H,20,23)
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n/an/a 55.6n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))		BDBM399956
PNG
(US10323042, Example 36)
Show SMILES CCNC(=O)c1nn2CCCOc2c1-c1cc(F)c(cc1C)C#N
Show InChI InChI=1S/C17H17FN4O2/c1-3-20-16(23)15-14(17-22(21-15)5-4-6-24-17)12-8-13(18)11(9-19)7-10(12)2/h7-8H,3-6H2,1-2H3,(H,20,23)
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n/an/a 56n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM399933
PNG
(US10323042, Example 13)
Show SMILES Fc1cc(ccc1Cl)-c1c2OCCCn2nc1C(=O)NC1CC1
Show InChI InChI=1S/C16H15ClFN3O2/c17-11-5-2-9(8-12(11)18)13-14(15(22)19-10-3-4-10)20-21-6-1-7-23-16(13)21/h2,5,8,10H,1,3-4,6-7H2,(H,19,22)
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Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM399935
PNG
(US10323042, Example 15)
Show SMILES Fc1cc(ccc1Cl)-c1c2OCCCn2nc1C(=O)N1CCC1
Show InChI InChI=1S/C16H15ClFN3O2/c17-11-4-3-10(9-12(11)18)13-14(15(22)20-5-1-6-20)19-21-7-2-8-23-16(13)21/h3-4,9H,1-2,5-8H2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 57.8n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform 1


(Homo sapiens (Human))		BDBM399968
PNG
(US10323042, Example 48)
Show SMILES Cc1cc(Cl)c(F)cc1-c1c2OCCCn2nc1C(=O)N1CCC1
Show InChI InChI=1S/C17H17ClFN3O2/c1-10-8-12(18)13(19)9-11(10)14-15(16(23)21-4-2-5-21)20-22-6-3-7-24-17(14)22/h8-9H,2-7H2,1H3
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 63.8n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3


(Homo sapiens (Human))		BDBM399965
PNG
(US10323042, Example 45)
Show SMILES Fc1ccc(cc1Cl)-c1c2OCCCn2nc1C(=O)NC1CC1
Show InChI InChI=1S/C16H15ClFN3O2/c17-11-8-9(2-5-12(11)18)13-14(15(22)19-10-3-4-10)20-21-6-1-7-23-16(13)21/h2,5,8,10H,1,3-4,6-7H2,(H,19,22)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 64n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...

US Patent US10323042 (2019)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%