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Patent code US10323060

Compile Data Set for Download or QSAR
Found 37 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bile acid receptor


(Homo sapiens (Human))
BDBM379113
PNG
(US10266560, Example CDCA | US10323060, Example CDC...)
Show SMILES C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)CC4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
Show InChI InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15?,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM400021
PNG
(US10323060, Example 34)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)CC4CC4c4ccc(cc4)C(O)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C34H50O4/c1-5-24-29-18-23(35)12-14-34(29,4)28-13-15-33(3)26(10-11-27(33)30(28)31(24)36)19(2)16-22-17-25(22)20-6-8-21(9-7-20)32(37)38/h6-9,19,22-31,35-36H,5,10-18H2,1-4H3,(H,37,38)/t19-,22?,23-,24-,25?,26-,27+,28+,29+,30+,31-,33-,34-/m1/s1
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n/an/an/an/a 5.50E+3n/an/an/an/a



Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM399997
PNG
(US10323060, Example 10)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)CC4CC4c4ccccc4C(O)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C34H50O4/c1-5-22-29-18-21(35)12-14-34(29,4)28-13-15-33(3)26(10-11-27(33)30(28)31(22)36)19(2)16-20-17-25(20)23-8-6-7-9-24(23)32(37)38/h6-9,19-22,25-31,35-36H,5,10-18H2,1-4H3,(H,37,38)/t19-,20?,21-,22-,25?,26-,27+,28+,29+,30+,31-,33-,34-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM399990
PNG
(US10323060, Example 3)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)CCCc4ccccc4C(O)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C33H50O4/c1-5-23-28-19-22(34)15-17-33(28,4)27-16-18-32(3)25(13-14-26(32)29(27)30(23)35)20(2)9-8-11-21-10-6-7-12-24(21)31(36)37/h6-7,10,12,20,22-23,25-30,34-35H,5,8-9,11,13-19H2,1-4H3,(H,36,37)/t20-,22-,23-,25-,26+,27+,28+,29+,30-,32-,33-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM400000
PNG
(US10323060, Example 13)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)C\C=C\c4ccc(C(O)=O)c(O)c4)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C33H48O5/c1-5-22-27-18-21(34)13-15-33(27,4)26-14-16-32(3)24(11-12-25(32)29(26)30(22)36)19(2)7-6-8-20-9-10-23(31(37)38)28(35)17-20/h6,8-10,17,19,21-22,24-27,29-30,34-36H,5,7,11-16,18H2,1-4H3,(H,37,38)/b8-6+/t19-,21-,22-,24-,25+,26+,27+,29+,30-,32-,33-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM400008
PNG
(US10323060, Example 21)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)C\C=C\c4cccc(c4)C(=O)OC)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C34H50O4/c1-6-25-29-20-24(35)15-17-34(29,4)28-16-18-33(3)26(13-14-27(33)30(28)31(25)36)21(2)9-7-10-22-11-8-12-23(19-22)32(37)38-5/h7-8,10-12,19,21,24-31,35-36H,6,9,13-18,20H2,1-5H3/b10-7+/t21-,24-,25-,26-,27+,28+,29+,30+,31-,33-,34-/m1/s1
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n/an/an/an/a 5.50E+3n/an/an/an/a



Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM400014
PNG
(US10323060, Example 27)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)C\C=C\c4cnccc4C(=O)OC)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C33H49NO4/c1-6-23-28-18-22(35)12-15-33(28,4)27-13-16-32(3)25(10-11-26(32)29(27)30(23)36)20(2)8-7-9-21-19-34-17-14-24(21)31(37)38-5/h7,9,14,17,19-20,22-23,25-30,35-36H,6,8,10-13,15-16,18H2,1-5H3/b9-7+/t20-,22-,23-,25-,26+,27+,28+,29+,30-,32-,33-/m1/s1
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n/an/an/an/a 5.50E+3n/an/an/an/a



Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM400017
PNG
(US10323060, Example 30)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)C\C=C\c4ccccc4-c4nnn[nH]4)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM400022
PNG
(US10323060, Example 35)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)CCOc4ccc(F)cc4C(O)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C32H47FO5/c1-5-21-26-17-20(34)10-13-32(26,4)25-11-14-31(3)23(7-8-24(31)28(25)29(21)35)18(2)12-15-38-27-9-6-19(33)16-22(27)30(36)37/h6,9,16,18,20-21,23-26,28-29,34-35H,5,7-8,10-15,17H2,1-4H3,(H,36,37)/t18-,20-,21-,23-,24+,25+,26+,28+,29-,31-,32-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM399992
PNG
(US10323060, Example 5)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)CCCc4cc(F)c(O)c(F)c4)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C32H48F2O3/c1-5-21-25-17-20(35)11-13-32(25,4)24-12-14-31(3)22(9-10-23(31)28(24)29(21)36)18(2)7-6-8-19-15-26(33)30(37)27(34)16-19/h15-16,18,20-25,28-29,35-37H,5-14,17H2,1-4H3/t18-,20-,21-,22-,23+,24+,25+,28+,29-,31-,32-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM399998
PNG
(US10323060, Example 11)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)CCOc4ccccc4C(O)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C32H48O5/c1-5-21-26-18-20(33)12-15-32(26,4)25-13-16-31(3)23(10-11-24(31)28(25)29(21)34)19(2)14-17-37-27-9-7-6-8-22(27)30(35)36/h6-9,19-21,23-26,28-29,33-34H,5,10-18H2,1-4H3,(H,35,36)/t19-,20-,21-,23-,24+,25+,26+,28+,29-,31-,32-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM400001
PNG
(US10323060, Example 14)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)CCCc4ccc(C(O)=O)c(O)c4)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C33H50O5/c1-5-22-27-18-21(34)13-15-33(27,4)26-14-16-32(3)24(11-12-25(32)29(26)30(22)36)19(2)7-6-8-20-9-10-23(31(37)38)28(35)17-20/h9-10,17,19,21-22,24-27,29-30,34-36H,5-8,11-16,18H2,1-4H3,(H,37,38)/t19-,21-,22-,24-,25+,26+,27+,29+,30-,32-,33-/m1/s1
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n/an/an/an/a 5.50E+3n/an/an/an/a



Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM400010
PNG
(US10323060, Example 23)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)CCCc4cccc(c4)C(O)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C33H50O4/c1-5-24-28-19-23(34)14-16-33(28,4)27-15-17-32(3)25(12-13-26(32)29(27)30(24)35)20(2)8-6-9-21-10-7-11-22(18-21)31(36)37/h7,10-11,18,20,23-30,34-35H,5-6,8-9,12-17,19H2,1-4H3,(H,36,37)/t20-,23-,24-,25-,26+,27+,28+,29+,30-,32-,33-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM400012
PNG
(US10323060, Example 25)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)C\C=C\c4ccc(F)cc4C(O)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C33H47FO4/c1-5-23-28-18-22(35)13-15-33(28,4)27-14-16-32(3)25(11-12-26(32)29(27)30(23)36)19(2)7-6-8-20-9-10-21(34)17-24(20)31(37)38/h6,8-10,17,19,22-23,25-30,35-36H,5,7,11-16,18H2,1-4H3,(H,37,38)/b8-6+/t19-,22-,23-,25-,26+,27+,28+,29+,30-,32-,33-/m1/s1
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n/an/an/an/a<100n/an/an/an/a



Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM399988
PNG
(US10323060, Example 1 | US10323060, Example 2)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)C\C=C\c4ccccc4C(=O)OC)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C34H50O4/c1-6-24-29-20-23(35)16-18-34(29,4)28-17-19-33(3)26(14-15-27(33)30(28)31(24)36)21(2)10-9-12-22-11-7-8-13-25(22)32(37)38-5/h7-9,11-13,21,23-24,26-31,35-36H,6,10,14-20H2,1-5H3/b12-9+/t21-,23-,24-,26-,27+,28+,29+,30+,31-,33-,34-/m1/s1
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n/an/an/an/a<100n/an/an/an/a



Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM400003
PNG
(US10323060, Example 16)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)C\C=C\c4ccc(cc4)C(C)C(O)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C35H52O4/c1-6-26-30-20-25(36)16-18-35(30,5)29-17-19-34(4)27(14-15-28(34)31(29)32(26)37)21(2)8-7-9-23-10-12-24(13-11-23)22(3)33(38)39/h7,9-13,21-22,25-32,36-37H,6,8,14-20H2,1-5H3,(H,38,39)/b9-7+/t21-,22?,25-,26-,27-,28+,29+,30+,31+,32-,34-,35-/m1/s1
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n/an/an/an/a 5.50E+3n/an/an/an/a



Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM400005
PNG
(US10323060, Example 18)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)C\C=C\c4ccc(cc4)C(=O)OC)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C34H50O4/c1-6-25-29-20-24(35)16-18-34(29,4)28-17-19-33(3)26(14-15-27(33)30(28)31(25)36)21(2)8-7-9-22-10-12-23(13-11-22)32(37)38-5/h7,9-13,21,24-31,35-36H,6,8,14-20H2,1-5H3/b9-7+/t21-,24-,25-,26-,27+,28+,29+,30+,31-,33-,34-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM400009
PNG
(US10323060, Example 22)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)C\C=C\c4cccc(c4)C(O)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C33H48O4/c1-5-24-28-19-23(34)14-16-33(28,4)27-15-17-32(3)25(12-13-26(32)29(27)30(24)35)20(2)8-6-9-21-10-7-11-22(18-21)31(36)37/h6-7,9-11,18,20,23-30,34-35H,5,8,12-17,19H2,1-4H3,(H,36,37)/b9-6+/t20-,23-,24-,25-,26+,27+,28+,29+,30-,32-,33-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM400019
PNG
(US10323060, Example 32)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)Cc4nc5cccc(C(O)=O)c5[nH]4)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM399987
PNG
(US10323060, Example 6 | US10323060, Example 6-ECDC...)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)Cc4nc5c(cccc5o4)C(=O)OC)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C33H47NO5/c1-6-20-25-17-19(35)12-14-33(25,4)24-13-15-32(3)22(10-11-23(32)28(24)30(20)36)18(2)16-27-34-29-21(31(37)38-5)8-7-9-26(29)39-27/h7-9,18-20,22-25,28,30,35-36H,6,10-17H2,1-5H3/t18-,19-,20-,22-,23+,24+,25+,28+,30-,32-,33-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM399995
PNG
(US10323060, Example 8)
Show SMILES CCOC(=O)Cc1nnn(CCC[C@@H](C)[C@H]2CC[C@H]3[C@@H]4[C@H](O)[C@H](CC)[C@@H]5C[C@H](O)CC[C@]5(C)[C@H]4CC[C@]23C)n1
Show InChI InChI=1S/C31H52N4O4/c1-6-21-25-17-20(36)12-14-31(25,5)24-13-15-30(4)22(10-11-23(30)28(24)29(21)38)19(3)9-8-16-35-33-26(32-34-35)18-27(37)39-7-2/h19-25,28-29,36,38H,6-18H2,1-5H3/t19-,20-,21-,22-,23+,24+,25+,28+,29-,30-,31-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM399996
PNG
(US10323060, Example 9)
Show SMILES CCOC(=O)Cc1nnnn1CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3[C@H](O)[C@H](CC)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
Show InChI InChI=1S/C31H52N4O4/c1-6-21-25-17-20(36)12-14-31(25,5)24-13-15-30(4)22(10-11-23(30)28(24)29(21)38)19(3)9-8-16-35-26(32-33-34-35)18-27(37)39-7-2/h19-25,28-29,36,38H,6-18H2,1-5H3/t19-,20-,21-,22-,23+,24+,25+,28+,29-,30-,31-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM400007
PNG
(US10323060, Example 20)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)CCCc4ccc(cc4)C(O)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C33H50O4/c1-5-24-28-19-23(34)15-17-33(28,4)27-16-18-32(3)25(13-14-26(32)29(27)30(24)35)20(2)7-6-8-21-9-11-22(12-10-21)31(36)37/h9-12,20,23-30,34-35H,5-8,13-19H2,1-4H3,(H,36,37)/t20-,23-,24-,25-,26+,27+,28+,29+,30-,32-,33-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM400015
PNG
(US10323060, Example 28)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)C\C=C\c4cnccc4C(O)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C32H47NO4/c1-5-22-27-17-21(34)11-14-32(27,4)26-12-15-31(3)24(9-10-25(31)28(26)29(22)35)19(2)7-6-8-20-18-33-16-13-23(20)30(36)37/h6,8,13,16,18-19,21-22,24-29,34-35H,5,7,9-12,14-15,17H2,1-4H3,(H,36,37)/b8-6+/t19-,21-,22-,24-,25+,26+,27+,28+,29-,31-,32-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM399987
PNG
(US10323060, Example 6 | US10323060, Example 6-ECDC...)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)Cc4nc5c(cccc5o4)C(=O)OC)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C33H47NO5/c1-6-20-25-17-19(35)12-14-33(25,4)24-13-15-32(3)22(10-11-23(32)28(24)30(20)36)18(2)16-27-34-29-21(31(37)38-5)8-7-9-26(29)39-27/h7-9,18-20,22-25,28,30,35-36H,6,10-17H2,1-5H3/t18-,19-,20-,22-,23+,24+,25+,28+,30-,32-,33-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM400004
PNG
(US10323060, Example 17)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)CCCc4ccc(cc4)C(C)C(O)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C35H54O4/c1-6-26-30-20-25(36)16-18-35(30,5)29-17-19-34(4)27(14-15-28(34)31(29)32(26)37)21(2)8-7-9-23-10-12-24(13-11-23)22(3)33(38)39/h10-13,21-22,25-32,36-37H,6-9,14-20H2,1-5H3,(H,38,39)/t21-,22?,25-,26-,27-,28+,29+,30+,31+,32-,34-,35-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM400011
PNG
(US10323060, Example 24)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)C\C=C\c4ccc(cc4)-c4nnn[nH]4)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM400016
PNG
(US10323060, Example 29)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)C\C=C\c4ccccc4C#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C33H47NO2/c1-5-25-29-19-24(35)15-17-33(29,4)28-16-18-32(3)26(13-14-27(32)30(28)31(25)36)21(2)9-8-12-22-10-6-7-11-23(22)20-34/h6-8,10-12,21,24-31,35-36H,5,9,13-19H2,1-4H3/b12-8+/t21-,24-,25-,26-,27+,28+,29+,30+,31-,32-,33-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM400018
PNG
(US10323060, Example 31)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)Cc4nc5cccc(C(=O)OC)c5[nH]4)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM399991
PNG
(US10323060, Example 4)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)CC=Cc4cc(F)c(O)c(F)c4)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C32H46F2O3/c1-5-21-25-17-20(35)11-13-32(25,4)24-12-14-31(3)22(9-10-23(31)28(24)29(21)36)18(2)7-6-8-19-15-26(33)30(37)27(34)16-19/h6,8,15-16,18,20-25,28-29,35-37H,5,7,9-14,17H2,1-4H3/t18-,20-,21-,22-,23+,24+,25+,28+,29-,31-,32-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM400006
PNG
(US10323060, Example 19)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)C\C=C\c4ccc(cc4)C(O)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C33H48O4/c1-5-24-28-19-23(34)15-17-33(28,4)27-16-18-32(3)25(13-14-26(32)29(27)30(24)35)20(2)7-6-8-21-9-11-22(12-10-21)31(36)37/h6,8-12,20,23-30,34-35H,5,7,13-19H2,1-4H3,(H,36,37)/b8-6+/t20-,23-,24-,25-,26+,27+,28+,29+,30-,32-,33-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM399988
PNG
(US10323060, Example 1 | US10323060, Example 2)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)C\C=C\c4ccccc4C(=O)OC)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C34H50O4/c1-6-24-29-20-23(35)16-18-34(29,4)28-17-19-33(3)26(14-15-27(33)30(28)31(24)36)21(2)10-9-12-22-11-7-8-13-25(22)32(37)38-5/h7-9,11-13,21,23-24,26-31,35-36H,6,10,14-20H2,1-5H3/b12-9+/t21-,23-,24-,26-,27+,28+,29+,30+,31-,33-,34-/m1/s1
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Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM399999
PNG
(US10323060, Example 12)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)C\C=C\c4ccc(C(=O)OC)c(O)c4)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C34H50O5/c1-6-23-28-19-22(35)14-16-34(28,4)27-15-17-33(3)25(12-13-26(33)30(27)31(23)37)20(2)8-7-9-21-10-11-24(29(36)18-21)32(38)39-5/h7,9-11,18,20,22-23,25-28,30-31,35-37H,6,8,12-17,19H2,1-5H3/b9-7+/t20-,22-,23-,25-,26+,27+,28+,30+,31-,33-,34-/m1/s1
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n/an/an/an/a 5.50E+3n/an/an/an/a



Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM400002
PNG
(US10323060, Example 15)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)C\C=C\c4ccc(cc4)C(C)C(=O)OC)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C36H54O4/c1-7-27-31-21-26(37)17-19-36(31,5)30-18-20-35(4)28(15-16-29(35)32(30)33(27)38)22(2)9-8-10-24-11-13-25(14-12-24)23(3)34(39)40-6/h8,10-14,22-23,26-33,37-38H,7,9,15-21H2,1-6H3/b10-8+/t22-,23?,26-,27-,28-,29+,30+,31+,32+,33-,35-,36-/m1/s1
PDB
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US Patent
n/an/an/an/a 5.50E+3n/an/an/an/a



Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM400013
PNG
(US10323060, Example 26)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)CCCc4ccc(F)cc4C(O)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C33H49FO4/c1-5-23-28-18-22(35)13-15-33(28,4)27-14-16-32(3)25(11-12-26(32)29(27)30(23)36)19(2)7-6-8-20-9-10-21(34)17-24(20)31(37)38/h9-10,17,19,22-23,25-30,35-36H,5-8,11-16,18H2,1-4H3,(H,37,38)/t19-,22-,23-,25-,26+,27+,28+,29+,30-,32-,33-/m1/s1
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US Patent
n/an/an/an/a 550n/an/an/an/a



Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM400020
PNG
(US10323060, Example 33)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)CC4CC4c4cccc(c4)C(O)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C34H50O4/c1-5-24-29-18-23(35)11-13-34(29,4)28-12-14-33(3)26(9-10-27(33)30(28)31(24)36)19(2)15-22-17-25(22)20-7-6-8-21(16-20)32(37)38/h6-8,16,19,22-31,35-36H,5,9-15,17-18H2,1-4H3,(H,37,38)/t19-,22?,23-,24-,25?,26-,27+,28+,29+,30+,31-,33-,34-/m1/s1
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US Patent
n/an/an/an/a 5.50E+3n/an/an/an/a



Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))
BDBM399987
PNG
(US10323060, Example 6 | US10323060, Example 6-ECDC...)
Show SMILES CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)Cc4nc5c(cccc5o4)C(=O)OC)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
Show InChI InChI=1S/C33H47NO5/c1-6-20-25-17-19(35)12-14-33(25,4)24-13-15-32(3)22(10-11-23(32)28(24)30(20)36)18(2)16-27-34-29-21(31(37)38-5)8-7-9-26(29)39-27/h7-9,18-20,22-25,28,30,35-36H,6,10-17H2,1-5H3/t18-,19-,20-,22-,23+,24+,25+,28+,30-,32-,33-/m1/s1
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US Patent
n/an/an/an/a 550n/an/an/an/a



Enanta Pharmaceuticals Inc

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR. FXR Reporter Assay kit...


US Patent US10323060 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1G0R
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%