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Patent code US10328053

Compile Data Set for Download or QSAR
Found 138 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bile acid transporter


(Homo sapiens (Human))
BDBM400025
PNG
((1aS,6aS)-N-(3-chloro-4-fluorophenyl)-5-(2-((3,3-d...)
Show SMILES CNC(=O)C1(CC(F)(F)C1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(Cl)c2)n2[C@H]3C[C@H]3Cc12
Show InChI InChI=1S/C24H22ClF3N4O4/c1-10-17(19(33)21(35)31-23(22(36)29-2)8-24(27,28)9-23)16-6-11-5-15(11)32(16)18(10)20(34)30-12-3-4-14(26)13(25)7-12/h3-4,7,11,15H,5-6,8-9H2,1-2H3,(H,29,36)(H,30,34)(H,31,35)/t11-,15-/m0/s1
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n/an/an/an/a 63.6n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400029
PNG
(N-(3-chloro-4-fluorophenyl)-7-(2-((3,3-difluoro-1-...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)C(=O)NC2(C)CS(=O)(=O)C2)c2CCCn2c1C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C26H26ClF3N4O6S/c1-13-18(17-4-3-7-34(17)19(13)21(36)31-14-5-6-16(28)15(27)8-14)20(35)22(37)32-25(9-26(29,30)10-25)23(38)33-24(2)11-41(39,40)12-24/h5-6,8H,3-4,7,9-12H2,1-2H3,(H,31,36)(H,32,37)(H,33,38)
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n/an/an/an/a 103n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400044
PNG
(US10328053, Compound 22)
Show SMILES CNC(=O)C1(CC(F)(F)C1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(Cl)c2)n2[C@H](C)CCc12
Show InChI InChI=1S/C24H24ClF3N4O4/c1-11-4-7-16-17(19(33)21(35)31-23(22(36)29-3)9-24(27,28)10-23)12(2)18(32(11)16)20(34)30-13-5-6-15(26)14(25)8-13/h5-6,8,11H,4,7,9-10H2,1-3H3,(H,29,36)(H,30,34)(H,31,35)/t11-/m1/s1
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n/an/an/an/a 37n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400050
PNG
(N-(3-chloro-4-fluorophenyl)-7-(2-((3,3-difluoro-1-...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)C(=O)N2CC3(C2)CN(C3)S(C)(=O)=O)c2CCCn2c1C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C28H29ClF3N5O6S/c1-15-20(19-4-3-7-37(19)21(15)23(39)33-16-5-6-18(30)17(29)8-16)22(38)24(40)34-27(9-28(31,32)10-27)25(41)35-11-26(12-35)13-36(14-26)44(2,42)43/h5-6,8H,3-4,7,9-14H2,1-2H3,(H,33,39)(H,34,40)
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n/an/an/an/a 112n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400063
PNG
((1aR,6aR)-N-(3-cyano-4-fluorophenyl)-5-(2-((3,3-di...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)c2c[nH]nn2)c2C[C@H]3C[C@H]3n2c1C(=O)Nc1ccc(F)c(c1)C#N
Show InChI InChI=1/C25H20F3N7O3/c1-11-19(21(36)23(38)32-24(9-25(27,28)10-24)18-8-30-34-33-18)17-6-12-5-16(12)35(17)20(11)22(37)31-14-2-3-15(26)13(4-14)7-29/h2-4,8,12,16H,5-6,9-10H2,1H3,(H,31,37)(H,32,38)(H,30,33,34)/t12-,16-/s2
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n/an/an/an/a 7.5n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400068
PNG
((S)-7-(2-((1-(1H-1,2,3-triazol-4-yl)cyclopropyl)am...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2c[nH]nn2)c2C[C@H](F)Cn2c1C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1/C22H19ClF2N6O3/c1-10-17(19(32)21(34)28-22(4-5-22)16-8-26-30-29-16)15-6-11(24)9-31(15)18(10)20(33)27-12-2-3-14(25)13(23)7-12/h2-3,7-8,11H,4-6,9H2,1H3,(H,27,33)(H,28,34)(H,26,29,30)/t11-/s2
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n/an/an/an/a 264n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400069
PNG
(7-(2-((3,3-difluoro-1-(methylcarbamoyl)cyclobutyl)...)
Show SMILES CNC(=O)C1(CC(F)(F)C1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)cc2)n2CCCc12
Show InChI InChI=1S/C23H23F3N4O4/c1-12-16(18(31)20(33)29-22(21(34)27-2)10-23(25,26)11-22)15-4-3-9-30(15)17(12)19(32)28-14-7-5-13(24)6-8-14/h5-8H,3-4,9-11H2,1-2H3,(H,27,34)(H,28,32)(H,29,33)
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n/an/an/an/a 56.3n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400076
PNG
((1aR,6aR)-5-(2-((1-(1,3,4-thiadiazol-2-yl)cyclopro...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2nncs2)c2C[C@H]3C[C@H]3n2c1C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C23H19ClFN5O3S/c1-10-17(19(31)21(33)28-23(4-5-23)22-29-26-9-34-22)16-7-11-6-15(11)30(16)18(10)20(32)27-12-2-3-14(25)13(24)8-12/h2-3,8-9,11,15H,4-7H2,1H3,(H,27,32)(H,28,33)/t11-,15-/m1/s1
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n/an/an/an/a 7.80n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400080
PNG
((1aR,6aR)-5-(2-((1-(1,3,4-thiadiazol-2-yl)cyclopro...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2nncs2)c2C[C@H]3C[C@H]3n2c1C(=O)Nc1ccc(F)c(c1)C#N
Show InChI InChI=1S/C24H19FN6O3S/c1-11-18(20(32)22(34)29-24(4-5-24)23-30-27-10-35-23)17-8-12-7-16(12)31(17)19(11)21(33)28-14-2-3-15(25)13(6-14)9-26/h2-3,6,10,12,16H,4-5,7-8H2,1H3,(H,28,33)(H,29,34)/t12-,16-/m1/s1
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n/an/an/an/a 27.3n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400085
PNG
((1aR,6aR)-5-(2-((1-(1H-1,2,3-triazol-4-yl)cyclopro...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2c[nH]nn2)c2C[C@H]3C[C@H]3n2c1C(=O)Nc1ccnc(C(F)F)c1F
Show InChI InChI=1/C23H20F3N7O3/c1-9-15(19(34)22(36)30-23(3-4-23)14-8-28-32-31-14)13-7-10-6-12(10)33(13)18(9)21(35)29-11-2-5-27-17(16(11)24)20(25)26/h2,5,8,10,12,20H,3-4,6-7H2,1H3,(H,30,36)(H,27,29,35)(H,28,31,32)/t10-,12-/s2
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n/an/an/an/a 71.1n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400087
PNG
(6-methyl-7-(2-((1-(5-methyl-1,3,4-oxadiazol-2-yl)c...)
Show SMILES Cc1nnc(o1)C1(CC1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2cc(F)c(F)c(F)c2)n2CCCc12
Show InChI InChI=1S/C23H20F3N5O4/c1-10-16(19(32)21(34)28-23(5-6-23)22-30-29-11(2)35-22)15-4-3-7-31(15)18(10)20(33)27-12-8-13(24)17(26)14(25)9-12/h8-9H,3-7H2,1-2H3,(H,27,33)(H,28,34)
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n/an/an/an/a 36.8n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400096
PNG
(7-(2-((1-(1H-1,2,3-triazol-4-yl)cyclopropyl)amino)...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2c[nH]nn2)c2CCCn2c1C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C22H21ClN6O3/c1-12-17(19(30)21(32)26-22(7-8-22)16-11-24-28-27-16)15-6-3-9-29(15)18(12)20(31)25-14-5-2-4-13(23)10-14/h2,4-5,10-11H,3,6-9H2,1H3,(H,25,31)(H,26,32)(H,24,27,28)
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n/an/an/an/a 42n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400098
PNG
(7-(2-((1-(1H-1,2,3-triazol-4-yl)cyclopropyl)amino)...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2c[nH]nn2)c2CCCn2c1C(=O)Nc1cc(F)cc(F)c1
Show InChI InChI=1S/C22H20F2N6O3/c1-11-17(19(31)21(33)27-22(4-5-22)16-10-25-29-28-16)15-3-2-6-30(15)18(11)20(32)26-14-8-12(23)7-13(24)9-14/h7-10H,2-6H2,1H3,(H,26,32)(H,27,33)(H,25,28,29)
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n/an/an/an/a 31.9n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400101
PNG
((1aR,6aR)-5-(2-((1-(1H-1,2,3-triazol-4-yl)cyclopro...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2c[nH]nn2)c2CC3C[C@H]3n2c1C(=O)Nc1ccc(F)c(c1)C#N
Show InChI InChI=1/C24H20FN7O3/c1-11-19(21(33)23(35)29-24(4-5-24)18-10-27-31-30-18)17-8-12-7-16(12)32(17)20(11)22(34)28-14-2-3-15(25)13(6-14)9-26/h2-3,6,10,12,16H,4-5,7-8H2,1H3,(H,28,34)(H,29,35)(H,27,30,31)/t12?,16-/s2
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n/an/an/an/a 47.8n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400115
PNG
(7-(2-((1-(1H-1,2,3-triazol-5-yl)cyclopropyl)amino)...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2cnn[nH]2)c2CCCn2c1C(=O)Nc1ccc(F)cc1F
Show InChI InChI=1S/C22H20F2N6O3/c1-11-17(19(31)21(33)27-22(6-7-22)16-10-25-29-28-16)15-3-2-8-30(15)18(11)20(32)26-14-5-4-12(23)9-13(14)24/h4-5,9-10H,2-3,6-8H2,1H3,(H,26,32)(H,27,33)(H,25,28,29)
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n/an/an/an/a 254n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400116
PNG
(N-(3-chloro-4-fluorophenyl)-7-(2-((1-ethynylcyclop...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)C#C)c2CCCn2c1C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C22H19ClFN3O3/c1-3-22(8-9-22)26-21(30)19(28)17-12(2)18(27-10-4-5-16(17)27)20(29)25-13-6-7-15(24)14(23)11-13/h1,6-7,11H,4-5,8-10H2,2H3,(H,25,29)(H,26,30)
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n/an/an/an/a 5.80n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400120
PNG
((1aR,6aR)-5-(2-((1-(1H-1,2,3-triazol-5-yl)cyclopro...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2cnn[nH]2)c2C[C@H]3C[C@H]3n2c1C(=O)Nc1ccc(F)cc1
Show InChI InChI=1/C23H21FN6O3/c1-11-18(20(31)22(33)27-23(6-7-23)17-10-25-29-28-17)16-9-12-8-15(12)30(16)19(11)21(32)26-14-4-2-13(24)3-5-14/h2-5,10,12,15H,6-9H2,1H3,(H,26,32)(H,27,33)(H,25,28,29)/t12-,15-/s2
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n/an/an/an/a 51.3n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400123
PNG
(7-(2-((1-(1H-1,2,3-triazol-4-yl)cyclopropyl)amino)...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2c[nH]nn2)c2CCCn2c1C(=O)Nc1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C22H20Cl2N6O3/c1-11-17(19(31)21(33)27-22(4-5-22)16-10-25-29-28-16)15-3-2-6-30(15)18(11)20(32)26-14-8-12(23)7-13(24)9-14/h7-10H,2-6H2,1H3,(H,26,32)(H,27,33)(H,25,28,29)
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n/an/an/an/a 112n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400133
PNG
(7-(2-((3,3-difluoro-1-(methylcarbamoyl)cyclobutyl)...)
Show SMILES CNC(=O)C1(CC(F)(F)C1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2cccc(c2)C(F)F)n2CCCc12
Show InChI InChI=1S/C24H24F4N4O4/c1-12-16(18(33)21(35)31-23(22(36)29-2)10-24(27,28)11-23)15-7-4-8-32(15)17(12)20(34)30-14-6-3-5-13(9-14)19(25)26/h3,5-6,9,19H,4,7-8,10-11H2,1-2H3,(H,29,36)(H,30,34)(H,31,35)
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n/an/an/an/a 49.9n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400136
PNG
(7-(2-((3,3-difluoro-1-(hydroxymethyl)cyclobutyl)am...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CO)CC(F)(F)C2)c2CCCn2c1C(=O)Nc1ccc(F)c(F)c1
Show InChI InChI=1S/C22H21F4N3O4/c1-11-16(18(31)20(33)28-21(10-30)8-22(25,26)9-21)15-3-2-6-29(15)17(11)19(32)27-12-4-5-13(23)14(24)7-12/h4-5,7,30H,2-3,6,8-10H2,1H3,(H,27,32)(H,28,33)
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n/an/an/an/a 26.1n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400142
PNG
(7-(2-((1-(1H-1,2,3-triazol-4-yl)cyclopropyl)amino)...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2c[nH]nn2)c2CCCn2c1C(=O)Nc1cc(F)cc(c1)C#N
Show InChI InChI=1S/C23H20FN7O3/c1-12-18(20(32)22(34)28-23(4-5-23)17-11-26-30-29-17)16-3-2-6-31(16)19(12)21(33)27-15-8-13(10-25)7-14(24)9-15/h7-9,11H,2-6H2,1H3,(H,27,33)(H,28,34)(H,26,29,30)
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n/an/an/an/a 166n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400151
PNG
((R)-N-(3,4-difluorophenyl)-6-methyl-7-(2-oxo-2-((1...)
Show SMILES Cc1c(C(=O)C(=O)NC(C)(C(N)=O)C(F)(F)F)c2CCCn2c1C(=O)Nc1ccc(F)c(F)c1
Show InChI InChI=1S/C21H19F5N4O4/c1-9-14(16(31)18(33)29-20(2,19(27)34)21(24,25)26)13-4-3-7-30(13)15(9)17(32)28-10-5-6-11(22)12(23)8-10/h5-6,8H,3-4,7H2,1-2H3,(H2,27,34)(H,28,32)(H,29,33)
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n/an/an/an/a 79.9n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400027
PNG
(7-(2-((1-(1H-1,2,3-Triazol-4-yl)cyclopropyl)amino)...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2c[nH]nn2)c2CCCn2c1C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C22H20ClFN6O3/c1-11-17(19(31)21(33)27-22(6-7-22)16-10-25-29-28-16)15-3-2-8-30(15)18(11)20(32)26-12-4-5-14(24)13(23)9-12/h4-5,9-10H,2-3,6-8H2,1H3,(H,26,32)(H,27,33)(H,25,28,29)
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n/an/an/an/a 11.1n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400033
PNG
(7-(2-((1-(1,3,4-thiadiazol-2-yl)cyclopropyl)amino)...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2nncs2)c2CCCn2c1C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C22H19ClFN5O3S/c1-11-16(18(30)20(32)27-22(6-7-22)21-28-25-10-33-21)15-3-2-8-29(15)17(11)19(31)26-12-4-5-14(24)13(23)9-12/h4-5,9-10H,2-3,6-8H2,1H3,(H,26,31)(H,27,32)
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n/an/an/an/a 5n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400047
PNG
(US10328053, Compound 25)
Show SMILES C[C@@H](NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(Cl)c2)n2[C@@H](C)CCc12)C(F)(F)F
Show InChI InChI=1S/C21H20ClF4N3O3/c1-9-4-7-15-16(18(30)20(32)27-11(3)21(24,25)26)10(2)17(29(9)15)19(31)28-12-5-6-14(23)13(22)8-12/h5-6,8-9,11H,4,7H2,1-3H3,(H,27,32)(H,28,31)/t9-,11+/m0/s1
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n/an/an/an/a 408n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400054
PNG
(7-(2-((3,3-difluoro-1-(1H-1,2,3-triazol-4-yl)cyclo...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)c2c[nH]nn2)c2CCCn2c1C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C23H21F3N6O3/c1-12-17(19(33)21(35)29-22(10-23(25,26)11-22)16-9-27-31-30-16)15-3-2-8-32(15)18(12)20(34)28-14-6-4-13(24)5-7-14/h4-7,9H,2-3,8,10-11H2,1H3,(H,28,34)(H,29,35)(H,27,30,31)
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n/an/an/an/a 8.5n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400057
PNG
(N-(3-cyano-4-fluorophenyl)-7-(2-((3,3-difluoro-1-(...)
Show SMILES CNC(=O)C1(CC(F)(F)C1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(c2)C#N)n2CCCc12
Show InChI InChI=1S/C24H22F3N5O4/c1-12-17(19(33)21(35)31-23(22(36)29-2)10-24(26,27)11-23)16-4-3-7-32(16)18(12)20(34)30-14-5-6-15(25)13(8-14)9-28/h5-6,8H,3-4,7,10-11H2,1-2H3,(H,29,36)(H,30,34)(H,31,35)
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n/an/an/an/a 109n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400061
PNG
((1aR,6aR)-N-(3-chloro-4-fluorophenyl)-5-(2-((3,3-d...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)c2c[nH]nn2)c2C[C@H]3C[C@H]3n2c1C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1/C24H20ClF3N6O3/c1-10-18(20(35)22(37)31-23(8-24(27,28)9-23)17-7-29-33-32-17)16-5-11-4-15(11)34(16)19(10)21(36)30-12-2-3-14(26)13(25)6-12/h2-3,6-7,11,15H,4-5,8-9H2,1H3,(H,30,36)(H,31,37)(H,29,32,33)/t11-,15-/s2
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n/an/an/an/a 2.10n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400075
PNG
(7-(2-((3,3-difluoro-1-(1H-1,2,3-triazol-4-yl)cyclo...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)c2c[nH]nn2)c2CCCn2c1C(=O)Nc1cc(F)c(F)c(F)c1
Show InChI InChI=1S/C23H19F5N6O3/c1-10-16(19(35)21(37)31-22(8-23(27,28)9-22)15-7-29-33-32-15)14-3-2-4-34(14)18(10)20(36)30-11-5-12(24)17(26)13(25)6-11/h5-7H,2-4,8-9H2,1H3,(H,30,36)(H,31,37)(H,29,32,33)
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n/an/an/an/a 3.20n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400082
PNG
(N-(3-chloro-4-fluorophenyl)-7-(2-((1-ethynyl-3,3-d...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)C#C)c2CCCn2c1C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C23H19ClF3N3O3/c1-3-22(10-23(26,27)11-22)29-21(33)19(31)17-12(2)18(30-8-4-5-16(17)30)20(32)28-13-6-7-15(25)14(24)9-13/h1,6-7,9H,4-5,8,10-11H2,2H3,(H,28,32)(H,29,33)
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n/an/an/an/a 1.80n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400084
PNG
((1aR,6aR)-5-(2-((1-(1,3,4-thiadiazol-2-yl)cyclopro...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2nncs2)c2C[C@H]3C[C@H]3n2c1C(=O)Nc1ccnc(c1)C(F)F
Show InChI InChI=1S/C23H20F2N6O3S/c1-10-16(18(32)21(34)29-23(3-4-23)22-30-27-9-35-22)15-7-11-6-14(11)31(15)17(10)20(33)28-12-2-5-26-13(8-12)19(24)25/h2,5,8-9,11,14,19H,3-4,6-7H2,1H3,(H,29,34)(H,26,28,33)/t11-,14-/m1/s1
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n/an/an/an/a 78.6n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400090
PNG
((1aR,6aR)-5-(2-((1-(1,3,4-thiadiazol-2-yl)cyclopro...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2nncs2)c2C[C@H]3C[C@H]3n2c1C(=O)Nc1ccnc(C(F)F)c1F
Show InChI InChI=1S/C23H19F3N6O3S/c1-9-14(18(33)21(35)30-23(3-4-23)22-31-28-8-36-22)13-7-10-6-12(10)32(13)17(9)20(34)29-11-2-5-27-16(15(11)24)19(25)26/h2,5,8,10,12,19H,3-4,6-7H2,1H3,(H,30,35)(H,27,29,34)/t10-,12-/m1/s1
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n/an/an/an/a 110n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400091
PNG
(7-(2-((1-(1H-1,2,3-triazol-4-yl)cyclopropyl)amino)...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2c[nH]nn2)c2CCCn2c1C(=O)Nc1cccc(F)c1
Show InChI InChI=1S/C22H21FN6O3/c1-12-17(19(30)21(32)26-22(7-8-22)16-11-24-28-27-16)15-6-3-9-29(15)18(12)20(31)25-14-5-2-4-13(23)10-14/h2,4-5,10-11H,3,6-9H2,1H3,(H,25,31)(H,26,32)(H,24,27,28)
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n/an/an/an/a 49.9n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400103
PNG
((1aR,6aR)-5-(2-(1-(1H-1,2,3triazol-4-yl)cyclopropy...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2c[nH]nn2)c2C[C@H]3C[C@H]3n2c1C(=O)Nc1ccc(F)c(F)c1
Show InChI InChI=1/C23H20F2N6O3/c1-10-18(20(32)22(34)28-23(4-5-23)17-9-26-30-29-17)16-7-11-6-15(11)31(16)19(10)21(33)27-12-2-3-13(24)14(25)8-12/h2-3,8-9,11,15H,4-7H2,1H3,(H,27,33)(H,28,34)(H,26,29,30)/t11-,15-/s2
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n/an/an/an/a 17.5n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400108
PNG
(7-(2-((1-(1H-1,2,3-triazol-5-yl)cyclopropyl)amino)...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2cnn[nH]2)c2CCCn2c1C(=O)Nc1cc(Cl)ccc1F
Show InChI InChI=1S/C22H20ClFN6O3/c1-11-17(19(31)21(33)27-22(6-7-22)16-10-25-29-28-16)15-3-2-8-30(15)18(11)20(32)26-14-9-12(23)4-5-13(14)24/h4-5,9-10H,2-3,6-8H2,1H3,(H,26,32)(H,27,33)(H,25,28,29)
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n/an/an/an/a 184n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400127
PNG
(7-(2-((3-carbamoylbicyclo[1.1.1]pentan-1-yl)amino)...)
Show SMILES Cc1c(C(=O)C(=O)NC23CC(C2)(C3)C(N)=O)c2CCCn2c1C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C23H22ClFN4O4/c1-11-16(18(30)20(32)28-23-8-22(9-23,10-23)21(26)33)15-3-2-6-29(15)17(11)19(31)27-12-4-5-14(25)13(24)7-12/h4-5,7H,2-3,6,8-10H2,1H3,(H2,26,33)(H,27,31)(H,28,32)
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n/an/an/an/a 124n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400130
PNG
(N-(3-chloro-4-fluorophenyl)-7-(2-((3-cyanobicyclo[...)
Show SMILES Cc1c(C(=O)C(=O)NC23CC(C2)(C3)C#N)c2CCCn2c1C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C23H20ClFN4O3/c1-12-17(19(30)21(32)28-23-8-22(9-23,10-23)11-26)16-3-2-6-29(16)18(12)20(31)27-13-4-5-15(25)14(24)7-13/h4-5,7H,2-3,6,8-10H2,1H3,(H,27,31)(H,28,32)
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n/an/an/an/a 29.9n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400147
PNG
(7-(2-((1-cyano-3,3-difluorocyclobutyl)amino)-2-oxo...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)C#N)c2CCCn2c1C(=O)Nc1ccc(F)c(F)c1
Show InChI InChI=1S/C22H18F4N4O3/c1-11-16(18(31)20(33)29-21(10-27)8-22(25,26)9-21)15-3-2-6-30(15)17(11)19(32)28-12-4-5-13(23)14(24)7-12/h4-5,7H,2-3,6,8-9H2,1H3,(H,28,32)(H,29,33)
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n/an/an/an/a 10.6n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400153
PNG
((R)-N-(3,4-difluorophenyl)-6-methyl-7-(2-oxo-2-((1...)
Show SMILES CNC(=O)C(C)(NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(F)c2)n2CCCc12)C(F)(F)F
Show InChI InChI=1S/C22H21F5N4O4/c1-10-15(17(32)19(34)30-21(2,20(35)28-3)22(25,26)27)14-5-4-8-31(14)16(10)18(33)29-11-6-7-12(23)13(24)9-11/h6-7,9H,4-5,8H2,1-3H3,(H,28,35)(H,29,33)(H,30,34)
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n/an/an/an/a 160n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400036
PNG
(N-(3-chloro-4-fluorophenyl)-7-(2-((3,3-difluoro-1-...)
Show SMILES CNC(=O)C1(CC(F)(F)C1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(Cl)c2)n2c1CCC2(C)C
Show InChI InChI=1S/C25H26ClF3N4O4/c1-12-17(19(34)21(36)32-24(22(37)30-4)10-25(28,29)11-24)16-7-8-23(2,3)33(16)18(12)20(35)31-13-5-6-15(27)14(26)9-13/h5-6,9H,7-8,10-11H2,1-4H3,(H,30,37)(H,31,35)(H,32,36)
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n/an/an/an/a 45.8n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400037
PNG
((R)-N-(3-chloro-4-fluorophenyl)-7-(2-((3,3-difluor...)
Show SMILES CNC(=O)C1(CC(F)(F)C1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(Cl)c2)n2C[C@H](O)Cc12
Show InChI InChI=1S/C23H22ClF3N4O5/c1-10-16(18(33)20(35)30-22(21(36)28-2)8-23(26,27)9-22)15-6-12(32)7-31(15)17(10)19(34)29-11-3-4-14(25)13(24)5-11/h3-5,12,32H,6-9H2,1-2H3,(H,28,36)(H,29,34)(H,30,35)/t12-/m1/s1
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n/an/an/an/a 456n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400039
PNG
(N-(3-chloro-4-fluorophenyl)-7-(2-((3,3-difluoro-1-...)
Show SMILES CNC(=O)C1(CC(F)(F)C1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(Cl)c2)n2C(C)CCc12
Show InChI InChI=1S/C24H24ClF3N4O4/c1-11-4-7-16-17(19(33)21(35)31-23(22(36)29-3)9-24(27,28)10-23)12(2)18(32(11)16)20(34)30-13-5-6-15(26)14(25)8-13/h5-6,8,11H,4,7,9-10H2,1-3H3,(H,29,36)(H,30,34)(H,31,35)
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n/an/an/an/a 33.2n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400052
PNG
((1aR,6aR)-N-(3-cyano-4-fluorophenyl)-5-(2-((3,3-di...)
Show SMILES CNC(=O)C1(CC(F)(F)C1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(c2)C#N)n2[C@@H]3C[C@@H]3Cc12
Show InChI InChI=1S/C25H22F3N5O4/c1-11-18(20(34)22(36)32-24(23(37)30-2)9-25(27,28)10-24)17-7-12-6-16(12)33(17)19(11)21(35)31-14-3-4-15(26)13(5-14)8-29/h3-5,12,16H,6-7,9-10H2,1-2H3,(H,30,37)(H,31,35)(H,32,36)/t12-,16-/m1/s1
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n/an/an/an/a 58.1n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400060
PNG
((1aR,6aR)-5-(2-((3,3-difluoro-1-(methylcarbamoyl)c...)
Show SMILES CNC(=O)C1(CC(F)(F)C1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2cc(F)c(F)c(F)c2)n2[C@@H]3C[C@@H]3Cc12
Show InChI InChI=1S/C24H21F5N4O4/c1-9-16(19(34)21(36)32-23(22(37)30-2)7-24(28,29)8-23)15-4-10-3-14(10)33(15)18(9)20(35)31-11-5-12(25)17(27)13(26)6-11/h5-6,10,14H,3-4,7-8H2,1-2H3,(H,30,37)(H,31,35)(H,32,36)/t10-,14-/m1/s1
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n/an/an/an/a 13n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400083
PNG
((1aR,6aR)-5-(2-((1-(1,3,4-thiadiazol-2-yl)cyclopro...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2nncs2)c2C[C@H]3C[C@H]3n2c1C(=O)Nc1ccc(F)c(F)c1
Show InChI InChI=1S/C23H19F2N5O3S/c1-10-17(19(31)21(33)28-23(4-5-23)22-29-26-9-34-22)16-7-11-6-15(11)30(16)18(10)20(32)27-12-2-3-13(24)14(25)8-12/h2-3,8-9,11,15H,4-7H2,1H3,(H,27,32)(H,28,33)/t11-,15-/m1/s1
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n/an/an/an/a 12.3n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400092
PNG
(7-(2-((1-(1H-1,2,3-triazol-4-yl)cyclopropyl)amino)...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2c[nH]nn2)c2CCCn2c1C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C22H21FN6O3/c1-12-17(19(30)21(32)26-22(8-9-22)16-11-24-28-27-16)15-3-2-10-29(15)18(12)20(31)25-14-6-4-13(23)5-7-14/h4-7,11H,2-3,8-10H2,1H3,(H,25,31)(H,26,32)(H,24,27,28)
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n/an/an/an/a 63.2n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400094
PNG
((1aR,6aR)-N-(3-cyano-4-fluorophenyl)-4-methyl-5-(2...)
Show SMILES Cc1c(C(=O)C(=O)NC2(C)CS(=O)(=O)C2)c2C[C@H]3C[C@H]3n2c1C(=O)Nc1ccc(F)c(c1)C#N
Show InChI InChI=1S/C23H21FN4O5S/c1-11-18(20(29)22(31)27-23(2)9-34(32,33)10-23)17-7-12-6-16(12)28(17)19(11)21(30)26-14-3-4-15(24)13(5-14)8-25/h3-5,12,16H,6-7,9-10H2,1-2H3,(H,26,30)(H,27,31)/t12-,16-/m1/s1
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n/an/an/an/a 69.8n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400099
PNG
(7-(2-((1-(1H-1,2,3-triazol-4-yl)cyclopropyl)amino)...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2c[nH]nn2)c2CCCn2c1C(=O)Nc1ccc(F)c(c1)C(F)F
Show InChI InChI=1S/C23H21F3N6O3/c1-11-17(19(33)22(35)29-23(6-7-23)16-10-27-31-30-16)15-3-2-8-32(15)18(11)21(34)28-12-4-5-14(24)13(9-12)20(25)26/h4-5,9-10,20H,2-3,6-8H2,1H3,(H,28,34)(H,29,35)(H,27,30,31)
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n/an/an/an/a 19n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400100
PNG
((1aR,6aR)-5-(2-((3,3-difluoro-1-(1H-1,2,3-triazol-...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)c2c[nH]nn2)c2C[C@H]3C[C@H]3n2c1C(=O)Nc1ccnc(c1)C(F)F
Show InChI InChI=1/C24H21F4N7O3/c1-10-17(19(36)22(38)32-23(8-24(27,28)9-23)16-7-30-34-33-16)15-5-11-4-14(11)35(15)18(10)21(37)31-12-2-3-29-13(6-12)20(25)26/h2-3,6-7,11,14,20H,4-5,8-9H2,1H3,(H,32,38)(H,29,31,37)(H,30,33,34)/t11-,14-/s2
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n/an/an/an/a 16.4n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400111
PNG
(7-(2-((3,3-difluoro-1-(1H-1,2,3-triazol-4-yl)cyclo...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)c2c[nH]nn2)c2CCCn2c1C(=O)Nc1ccc(F)c(c1)C(F)F
Show InChI InChI=1S/C24H21F5N6O3/c1-11-17(19(36)22(38)32-23(9-24(28,29)10-23)16-8-30-34-33-16)15-3-2-6-35(15)18(11)21(37)31-12-4-5-14(25)13(7-12)20(26)27/h4-5,7-8,20H,2-3,6,9-10H2,1H3,(H,31,37)(H,32,38)(H,30,33,34)
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n/an/an/an/a 2.90n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400125
PNG
(N-(3-chloro-4-fluorophenyl)-7-(2-((1,3-dihydroxy-2...)
Show SMILES Cc1c(C(=O)C(=O)NC(C)(CO)CO)c2CCCn2c1C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C21H23ClFN3O5/c1-11-16(18(29)20(31)25-21(2,9-27)10-28)15-4-3-7-26(15)17(11)19(30)24-12-5-6-14(23)13(22)8-12/h5-6,8,27-28H,3-4,7,9-10H2,1-2H3,(H,24,30)(H,25,31)
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n/an/an/an/a 96.4n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400141
PNG
(N-(3,4-difluorophenyl)-7-(2-((1-(dimethylcarbamoyl...)
Show SMILES CN(C)C(=O)C1(CC(F)(F)C1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(F)c2)n2CCCc12
Show InChI InChI=1S/C24H24F4N4O4/c1-12-17(19(33)21(35)30-23(22(36)31(2)3)10-24(27,28)11-23)16-5-4-8-32(16)18(12)20(34)29-13-6-7-14(25)15(26)9-13/h6-7,9H,4-5,8,10-11H2,1-3H3,(H,29,34)(H,30,35)
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n/an/an/an/a 23.1n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400150
PNG
((R)-7-(2-((3,3-difluoro-1-(1H-1,2,3-triazol-4-yl)c...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)c2c[nH]nn2)c2C[C@@H](F)Cn2c1C(=O)Nc1ccnc(C(F)F)c1F
Show InChI InChI=1/C23H19F6N7O3/c1-9-14(18(37)21(39)33-22(7-23(28,29)8-22)13-5-31-35-34-13)12-4-10(24)6-36(12)17(9)20(38)32-11-2-3-30-16(15(11)25)19(26)27/h2-3,5,10,19H,4,6-8H2,1H3,(H,33,39)(H,30,32,38)(H,31,34,35)/t10-/s2
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n/an/an/an/a 23.8n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400151
PNG
((R)-N-(3,4-difluorophenyl)-6-methyl-7-(2-oxo-2-((1...)
Show SMILES Cc1c(C(=O)C(=O)NC(C)(C(N)=O)C(F)(F)F)c2CCCn2c1C(=O)Nc1ccc(F)c(F)c1
Show InChI InChI=1S/C21H19F5N4O4/c1-9-14(16(31)18(33)29-20(2,19(27)34)21(24,25)26)13-4-3-7-30(13)15(9)17(32)28-10-5-6-11(22)12(23)8-10/h5-6,8H,3-4,7H2,1-2H3,(H2,27,34)(H,28,32)(H,29,33)
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n/an/an/an/a 70.1n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400157
PNG
(7-(2-((3,3-difluoro-1-(methylcarbamoyl)cyclobutyl)...)
Show SMILES CNC(=O)C1(CC(F)(F)C1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccnc(C(F)F)c2F)n2CCCc12
Show InChI InChI=1S/C23H22F5N5O4/c1-10-13(17(34)20(36)32-22(21(37)29-2)8-23(27,28)9-22)12-4-3-7-33(12)16(10)19(35)31-11-5-6-30-15(14(11)24)18(25)26/h5-6,18H,3-4,7-9H2,1-2H3,(H,29,37)(H,32,36)(H,30,31,35)
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n/an/an/an/a 103n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400024
PNG
(N-(3-chloro-4-fluorophenyl)-7-(2-((3,3-difluoro-1-...)
Show SMILES CNC(=O)C1(CC(F)(F)C1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(Cl)c2)n2CCCc12
Show InChI InChI=1S/C23H22ClF3N4O4/c1-11-16(18(32)20(34)30-22(21(35)28-2)9-23(26,27)10-22)15-4-3-7-31(15)17(11)19(33)29-12-5-6-14(25)13(24)8-12/h5-6,8H,3-4,7,9-10H2,1-2H3,(H,28,35)(H,29,33)(H,30,34)
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n/an/an/an/a 14.9n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400035
PNG
(N-(3-chloro-4-fluorophenyl)-7-(2-((3,3-difluoro-1-...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)C(=O)N2CC(F)C2)c2CCCn2c1C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C25H23ClF4N4O4/c1-12-18(17-3-2-6-34(17)19(12)21(36)31-14-4-5-16(28)15(26)7-14)20(35)22(37)32-24(10-25(29,30)11-24)23(38)33-8-13(27)9-33/h4-5,7,13H,2-3,6,8-11H2,1H3,(H,31,36)(H,32,37)
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n/an/an/an/a 8.80n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400046
PNG
(US10328053, Compound 24)
Show SMILES C[C@@H](NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(Cl)c2)n2[C@H](C)CCc12)C(F)(F)F
Show InChI InChI=1S/C21H20ClF4N3O3/c1-9-4-7-15-16(18(30)20(32)27-11(3)21(24,25)26)10(2)17(29(9)15)19(31)28-12-5-6-14(23)13(22)8-12/h5-6,8-9,11H,4,7H2,1-3H3,(H,27,32)(H,28,31)/t9-,11-/m1/s1
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n/an/an/an/a 43.7n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400053
PNG
(7-(2-((3,3-difluoro-1-(1H-1,2,3-triazol-4-yl)cyclo...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)c2c[nH]nn2)c2CCCn2c1C(=O)Nc1ccc(F)c(F)c1
Show InChI InChI=1S/C23H20F4N6O3/c1-11-17(19(34)21(36)30-22(9-23(26,27)10-22)16-8-28-32-31-16)15-3-2-6-33(15)18(11)20(35)29-12-4-5-13(24)14(25)7-12/h4-5,7-8H,2-3,6,9-10H2,1H3,(H,29,35)(H,30,36)(H,28,31,32)
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n/an/an/an/a 3.20n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400062
PNG
((1aR,6aR)-5-(2-((3,3-difluoro-1-(1H-1,2,3-triazol-...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)c2c[nH]nn2)c2C[C@H]3C[C@H]3n2c1C(=O)Nc1cc(F)c(F)c(F)c1
Show InChI InChI=1/C24H19F5N6O3/c1-9-17(20(36)22(38)32-23(7-24(28,29)8-23)16-6-30-34-33-16)15-3-10-2-14(10)35(15)19(9)21(37)31-11-4-12(25)18(27)13(26)5-11/h4-6,10,14H,2-3,7-8H2,1H3,(H,31,37)(H,32,38)(H,30,33,34)/t10-,14-/s2
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n/an/an/an/a 1.90n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400070
PNG
((R)-7-(2-((3,3-difluoro-1-(1H-1,2,3-triazol-4-yl)c...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)c2c[nH]nn2)c2C[C@@H](F)Cn2c1C(=O)Nc1ccc(F)cc1
Show InChI InChI=1/C23H20F4N6O3/c1-11-17(19(34)21(36)30-22(9-23(26,27)10-22)16-7-28-32-31-16)15-6-13(25)8-33(15)18(11)20(35)29-14-4-2-12(24)3-5-14/h2-5,7,13H,6,8-10H2,1H3,(H,29,35)(H,30,36)(H,28,31,32)/t13-/s2
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n/an/an/an/a 6.5n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400078
PNG
((1aR,6aR)-5-(2-((1-(1H-1,2,3-triazol-4-yl)cyclopro...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2c[nH]nn2)c2C[C@H]3C[C@H]3n2c1C(=O)Nc1ccnc(c1)C(F)F
Show InChI InChI=1/C23H21F2N7O3/c1-10-17(19(33)22(35)29-23(3-4-23)16-9-27-31-30-16)15-7-11-6-14(11)32(15)18(10)21(34)28-12-2-5-26-13(8-12)20(24)25/h2,5,8-9,11,14,20H,3-4,6-7H2,1H3,(H,29,35)(H,26,28,34)(H,27,30,31)/t11-,14-/s2
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n/an/an/an/a 87.1n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400089
PNG
(6-methyl-7-(2-oxo-2-((1-phenylcyclopropyl)amino)ac...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2ccccc2)c2CCCn2c1C(=O)Nc1cc(F)c(F)c(F)c1
Show InChI InChI=1S/C26H22F3N3O3/c1-14-20(23(33)25(35)31-26(9-10-26)15-6-3-2-4-7-15)19-8-5-11-32(19)22(14)24(34)30-16-12-17(27)21(29)18(28)13-16/h2-4,6-7,12-13H,5,8-11H2,1H3,(H,30,34)(H,31,35)
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n/an/an/an/a 6.5n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400110
PNG
(7-(2-((3-(1H-1,2,3-triazol-4-yl)oxetan-3-yl)amino)...)
Show SMILES Cc1c(C(=O)C(=O)NC2(COC2)c2c[nH]nn2)c2CCCn2c1C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C22H20ClFN6O4/c1-11-17(19(31)21(33)27-22(9-34-10-22)16-8-25-29-28-16)15-3-2-6-30(15)18(11)20(32)26-12-4-5-14(24)13(23)7-12/h4-5,7-8H,2-3,6,9-10H2,1H3,(H,26,32)(H,27,33)(H,25,28,29)
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n/an/an/an/a 8.70n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400114
PNG
(7-(2-((1-ethynylcyclopropyl)amino)-2-oxoacetyl)-6-...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)C#C)c2CCCn2c1C(=O)Nc1cc(F)c(F)c(F)c1
Show InChI InChI=1S/C22H18F3N3O3/c1-3-22(6-7-22)27-21(31)19(29)16-11(2)18(28-8-4-5-15(16)28)20(30)26-12-9-13(23)17(25)14(24)10-12/h1,9-10H,4-8H2,2H3,(H,26,30)(H,27,31)
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n/an/an/an/a 6.40n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400128
PNG
(7-(2-((1-(1H-1,2,3-triazol-4-yl)cyclopropyl)amino)...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2c[nH]nn2)c2CCCn2c1C(=O)Nc1cccc(Cl)c1F
Show InChI InChI=1S/C22H20ClFN6O3/c1-11-16(19(31)21(33)27-22(7-8-22)15-10-25-29-28-15)14-6-3-9-30(14)18(11)20(32)26-13-5-2-4-12(23)17(13)24/h2,4-5,10H,3,6-9H2,1H3,(H,26,32)(H,27,33)(H,25,28,29)
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n/an/an/an/a 146n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400129
PNG
(7-(2-((1-(1H-1,2,3-triazol-4-yl)cyclopropyl)amino)...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2c[nH]nn2)c2CCCn2c1C(=O)Nc1ccc(F)c(F)c1F
Show InChI InChI=1S/C22H19F3N6O3/c1-10-15(19(32)21(34)28-22(6-7-22)14-9-26-30-29-14)13-3-2-8-31(13)18(10)20(33)27-12-5-4-11(23)16(24)17(12)25/h4-5,9H,2-3,6-8H2,1H3,(H,27,33)(H,28,34)(H,26,29,30)
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n/an/an/an/a 154n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400135
PNG
(N-(3-chloro-4-fluorophenyl)-7-(2-((3,3-difluoro-1-...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CO)CC(F)(F)C2)c2CCCn2c1C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C22H21ClF3N3O4/c1-11-16(18(31)20(33)28-21(10-30)8-22(25,26)9-21)15-3-2-6-29(15)17(11)19(32)27-12-4-5-14(24)13(23)7-12/h4-5,7,30H,2-3,6,8-10H2,1H3,(H,27,32)(H,28,33)
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n/an/an/an/a 13.1n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400139
PNG
(7-(2-((1-carbamoyl-3,3-difluorocyclobutyl)amino)-2...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)C(N)=O)c2CCCn2c1C(=O)Nc1ccc(F)c(F)c1
Show InChI InChI=1S/C22H20F4N4O4/c1-10-15(17(31)19(33)29-21(20(27)34)8-22(25,26)9-21)14-3-2-6-30(14)16(10)18(32)28-11-4-5-12(23)13(24)7-11/h4-5,7H,2-3,6,8-9H2,1H3,(H2,27,34)(H,28,32)(H,29,33)
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n/an/an/an/a 14.4n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400145
PNG
(N-(3-chloro-4,5-difluorophenyl)-7-(2-((3,3-difluor...)
Show SMILES CNC(=O)C1(CC(F)(F)C1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2cc(F)c(F)c(Cl)c2)n2CCCc12
Show InChI InChI=1S/C23H21ClF4N4O4/c1-10-15(18(33)20(35)31-22(21(36)29-2)8-23(27,28)9-22)14-4-3-5-32(14)17(10)19(34)30-11-6-12(24)16(26)13(25)7-11/h6-7H,3-5,8-9H2,1-2H3,(H,29,36)(H,30,34)(H,31,35)
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n/an/an/an/a 20.4n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400149
PNG
((R)-N-(3,4-difluorophenyl)-6-methyl-7-(2-oxo-2-((1...)
Show SMILES Cc1c(C(=O)C(=O)NC(C)(CO)C(F)(F)F)c2CCCn2c1C(=O)Nc1ccc(F)c(F)c1
Show InChI InChI=1S/C21H20F5N3O4/c1-10-15(17(31)19(33)28-20(2,9-30)21(24,25)26)14-4-3-7-29(14)16(10)18(32)27-11-5-6-12(22)13(23)8-11/h5-6,8,30H,3-4,7,9H2,1-2H3,(H,27,32)(H,28,33)
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n/an/an/an/a 16.5n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400160
PNG
(N-(3,4-difluorophenyl)-6-methyl-7-(2-(((1s,3s)-3-m...)
Show SMILES Cc1c(C(=O)C(=O)N[C@]2(C)C[S@](=O)C2)c2CCCn2c1C(=O)Nc1ccc(F)c(F)c1
Show InChI InChI=1S/C21H21F2N3O4S/c1-11-16(18(27)20(29)25-21(2)9-31(30)10-21)15-4-3-7-26(15)17(11)19(28)24-12-5-6-13(22)14(23)8-12/h5-6,8H,3-4,7,9-10H2,1-2H3,(H,24,28)(H,25,29)/t21-,31+
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n/an/an/an/a 65.1n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400034
PNG
(N-(3-chloro-4-fluorophenyl)-7-(2-((1-(2,2-dioxido-...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)C(=O)N2CC3(C2)CS(=O)(=O)C3)c2CCCn2c1C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C27H26ClF3N4O6S/c1-14-19(18-3-2-6-35(18)20(14)22(37)32-15-4-5-17(29)16(28)7-15)21(36)23(38)33-26(8-27(30,31)9-26)24(39)34-10-25(11-34)12-42(40,41)13-25/h4-5,7H,2-3,6,8-13H2,1H3,(H,32,37)(H,33,38)
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n/an/an/an/a 252n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400038
PNG
((R)-N-(3-chloro-4-fluorophenyl)-3,3,6-trimethyl-7-...)
Show SMILES CC(NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(Cl)c2)n2c1CCC2(C)C)C(F)(F)F
Show InChI InChI=1S/C22H22ClF4N3O3/c1-10-16(18(31)20(33)28-11(2)22(25,26)27)15-7-8-21(3,4)30(15)17(10)19(32)29-12-5-6-14(24)13(23)9-12/h5-6,9,11H,7-8H2,1-4H3,(H,28,33)(H,29,32)
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n/an/an/an/a 64.5n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400048
PNG
(N-(3-chloro-4-fluorophenyl)-7-(2-((3,3-difluoro-1-...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2c[nH]nn2)c2CCCn2c1C(=O)Nc1cc(F)c(F)c(F)c1
Show InChI InChI=1S/C22H19F3N6O3/c1-10-16(19(32)21(34)28-22(4-5-22)15-9-26-30-29-15)14-3-2-6-31(14)18(10)20(33)27-11-7-12(23)17(25)13(24)8-11/h7-9H,2-6H2,1H3,(H,27,33)(H,28,34)(H,26,29,30)
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n/an/an/an/a 14.6n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400055
PNG
((1aS,6bR)-N-(3-chloro-4-fluorophenyl)-6-(2-((3,3-d...)
Show SMILES CNC(=O)C1(CC(F)(F)C1)NC(=O)C(=O)c1c(C)c(C(=O)OC)n2C[C@H]3C[C@H]3c12
Show InChI InChI=1S/C19H21F2N3O5/c1-8-11(13-10-4-9(10)5-24(13)12(8)16(27)29-3)14(25)15(26)23-18(17(28)22-2)6-19(20,21)7-18/h9-10H,4-7H2,1-3H3,(H,22,28)(H,23,26)/t9-,10-/m1/s1
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n/an/an/an/a 27.2n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400056
PNG
(US10328053, Compound 34)
Show SMILES CNC(=O)C1(CC(F)(F)C1)NC(=O)C(=O)c1c(C)c(C(=O)OC)n2C[C@@H]3C[C@@H]3c12
Show InChI InChI=1S/C19H21F2N3O5/c1-8-11(13-10-4-9(10)5-24(13)12(8)16(27)29-3)14(25)15(26)23-18(17(28)22-2)6-19(20,21)7-18/h9-10H,4-7H2,1-3H3,(H,22,28)(H,23,26)/t9-,10-/m0/s1
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n/an/an/an/a 202n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400073
PNG
(N-(3-chloro-4-fluorophenyl)-6-methyl-7-(2-((1-(5-m...)
Show SMILES Cc1nnc([nH]1)C1(CC1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(Cl)c2)n2CCCc12
Show InChI InChI=1S/C23H22ClFN6O3/c1-11-17(19(32)21(34)28-23(7-8-23)22-26-12(2)29-30-22)16-4-3-9-31(16)18(11)20(33)27-13-5-6-15(25)14(24)10-13/h5-6,10H,3-4,7-9H2,1-2H3,(H,27,33)(H,28,34)(H,26,29,30)
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n/an/an/an/a 75.9n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400074
PNG
((1aR,6aR)-5-(2-((1-(1H-1,2,3-triazol-4-yl)cyclopro...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2c[nH]nn2)c2C[C@H]3C[C@H]3n2c1C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1/C23H20ClFN6O3/c1-10-18(20(32)22(34)28-23(4-5-23)17-9-26-30-29-17)16-7-11-6-15(11)31(16)19(10)21(33)27-12-2-3-14(25)13(24)8-12/h2-3,8-9,11,15H,4-7H2,1H3,(H,27,33)(H,28,34)(H,26,29,30)/t11-,15-/s2
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n/an/an/an/a 7.70n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400105
PNG
(6-methyl-7-(2-((2-methyl-1-(methylamino)-1-oxoprop...)
Show SMILES CNC(=O)C(C)(C)NC(=O)C(=O)c1c(C)c(C(=O)Nc2cc(F)c(F)c(F)c2)n2CCCc12
Show InChI InChI=1S/C22H23F3N4O4/c1-10-15(18(30)20(32)28-22(2,3)21(33)26-4)14-6-5-7-29(14)17(10)19(31)27-11-8-12(23)16(25)13(24)9-11/h8-9H,5-7H2,1-4H3,(H,26,33)(H,27,31)(H,28,32)
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n/an/an/an/a 199n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400107
PNG
(7-(2-((1-(1H-1,2,3-triazol-5-yl)cyclopropyl)amino)...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2cnn[nH]2)c2CCCn2c1C(=O)Nc1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H21F3N6O4/c1-12-17(19(33)21(35)29-22(7-8-22)16-11-27-31-30-16)15-6-3-9-32(15)18(12)20(34)28-13-4-2-5-14(10-13)36-23(24,25)26/h2,4-5,10-11H,3,6-9H2,1H3,(H,28,34)(H,29,35)(H,27,30,31)
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n/an/an/an/a 294n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400117
PNG
((1aR,6aR)-5-(2-((3,3-difluoro-1-(methylcarbamoyl)c...)
Show SMILES CNC(=O)C1(CC(F)(F)C1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)cc2)n2[C@@H]3C[C@@H]3Cc12
Show InChI InChI=1S/C24H23F3N4O4/c1-11-17(19(32)21(34)30-23(22(35)28-2)9-24(26,27)10-23)16-8-12-7-15(12)31(16)18(11)20(33)29-14-5-3-13(25)4-6-14/h3-6,12,15H,7-10H2,1-2H3,(H,28,35)(H,29,33)(H,30,34)/t12-,15-/m1/s1
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n/an/an/an/a 33.7n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400121
PNG
((1aR,6aR)-5-(2-((3,3-difluoro-1-(1H-1,2,3-triazol-...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)c2cnn[nH]2)c2C[C@H]3C[C@H]3n2c1C(=O)Nc1ccc(F)cc1
Show InChI InChI=1/C24H21F3N6O3/c1-11-18(20(34)22(36)30-23(9-24(26,27)10-23)17-8-28-32-31-17)16-7-12-6-15(12)33(16)19(11)21(35)29-14-4-2-13(25)3-5-14/h2-5,8,12,15H,6-7,9-10H2,1H3,(H,29,35)(H,30,36)(H,28,31,32)/t12-,15-/s2
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n/an/an/an/a 3.70n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400126
PNG
(N-(3-chloro-4-fluorophenyl)-6-methyl-7-(2-((1-(met...)
Show SMILES CNC(=O)C1(CC1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(Cl)c2)n2CCCc12
Show InChI InChI=1S/C22H22ClFN4O4/c1-11-16(18(29)20(31)27-22(7-8-22)21(32)25-2)15-4-3-9-28(15)17(11)19(30)26-12-5-6-14(24)13(23)10-12/h5-6,10H,3-4,7-9H2,1-2H3,(H,25,32)(H,26,30)(H,27,31)
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n/an/an/an/a 170n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400132
PNG
(N-(3-(difluoromethyl)-4-fluorophenyl)-6-methyl-7-(...)
Show SMILES CNC(=O)C(C)(C)NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(c2)C(F)F)n2CCCc12
Show InChI InChI=1S/C23H25F3N4O4/c1-11-16(18(31)21(33)29-23(2,3)22(34)27-4)15-6-5-9-30(15)17(11)20(32)28-12-7-8-14(24)13(10-12)19(25)26/h7-8,10,19H,5-6,9H2,1-4H3,(H,27,34)(H,28,32)(H,29,33)
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n/an/an/an/a 156n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400138
PNG
(7-(2-((1-carbamoyl-3,3-difluorocyclobutyl)amino)-2...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)C(N)=O)c2CCCn2c1C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C22H20ClF3N4O4/c1-10-15(17(31)19(33)29-21(20(27)34)8-22(25,26)9-21)14-3-2-6-30(14)16(10)18(32)28-11-4-5-13(24)12(23)7-11/h4-5,7H,2-3,6,8-9H2,1H3,(H2,27,34)(H,28,32)(H,29,33)
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n/an/an/an/a 12.3n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400144
PNG
((S)-N-(3-chloro-4-fluorophenyl)-6-methyl-7-(2-((3-...)
Show SMILES CNC(=O)[C@@H](NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(Cl)c2)n2CCCc12)C(C)C
Show InChI InChI=1S/C23H26ClFN4O4/c1-11(2)18(21(31)26-4)28-23(33)20(30)17-12(3)19(29-9-5-6-16(17)29)22(32)27-13-7-8-15(25)14(24)10-13/h7-8,10-11,18H,5-6,9H2,1-4H3,(H,26,31)(H,27,32)(H,28,33)/t18-/m0/s1
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n/an/an/an/a 170n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400153
PNG
((R)-N-(3,4-difluorophenyl)-6-methyl-7-(2-oxo-2-((1...)
Show SMILES CNC(=O)C(C)(NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(F)c2)n2CCCc12)C(F)(F)F
Show InChI InChI=1S/C22H21F5N4O4/c1-10-15(17(32)19(34)30-21(2,20(35)28-3)22(25,26)27)14-5-4-8-31(14)16(10)18(33)29-11-6-7-12(23)13(24)9-11/h6-7,9H,4-5,8H2,1-3H3,(H,28,35)(H,29,33)(H,30,34)
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n/an/an/an/a 158n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400023
PNG
((R)-N-(3-chloro-4-fluorophenyl)-6-methyl-7-(2-oxo-...)
Show SMILES C[C@@H](NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(Cl)c2)n2CCCc12)C(F)(F)F
Show InChI InChI=1S/C20H18ClF4N3O3/c1-9-15(17(29)19(31)26-10(2)20(23,24)25)14-4-3-7-28(14)16(9)18(30)27-11-5-6-13(22)12(21)8-11/h5-6,8,10H,3-4,7H2,1-2H3,(H,26,31)(H,27,30)/t10-/m1/s1
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n/an/an/an/a 15.9n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400026
PNG
((1aR,6aR)-N-(3-chloro-4-fluorophenyl)-5-(2-((3,3-d...)
Show SMILES CNC(=O)C1(CC(F)(F)C1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(Cl)c2)n2[C@@H]3C[C@@H]3Cc12
Show InChI InChI=1S/C24H22ClF3N4O4/c1-10-17(19(33)21(35)31-23(22(36)29-2)8-24(27,28)9-23)16-6-11-5-15(11)32(16)18(10)20(34)30-12-3-4-14(26)13(25)7-12/h3-4,7,11,15H,5-6,8-9H2,1-2H3,(H,29,36)(H,30,34)(H,31,35)/t11-,15-/m1/s1
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n/an/an/an/a 8.80n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400029
PNG
(N-(3-chloro-4-fluorophenyl)-7-(2-((3,3-difluoro-1-...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)C(=O)NC2(C)CS(=O)(=O)C2)c2CCCn2c1C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C26H26ClF3N4O6S/c1-13-18(17-4-3-7-34(17)19(13)21(36)31-14-5-6-16(28)15(27)8-14)20(35)22(37)32-25(9-26(29,30)10-25)23(38)33-24(2)11-41(39,40)12-24/h5-6,8H,3-4,7,9-12H2,1-2H3,(H,31,36)(H,32,37)(H,33,38)
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n/an/an/an/a 72n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400040
PNG
(N-(3-cyano-4-fluorophenyl)-7-(2-((3,3-difluoro-1-(...)
Show SMILES CNC(=O)C1(CC(F)(F)C1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(c2)C#N)n2C(C)CCc12
Show InChI InChI=1S/C25H24F3N5O4/c1-12-4-7-17-18(20(34)22(36)32-24(23(37)30-3)10-25(27,28)11-24)13(2)19(33(12)17)21(35)31-15-5-6-16(26)14(8-15)9-29/h5-6,8,12H,4,7,10-11H2,1-3H3,(H,30,37)(H,31,35)(H,32,36)
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n/an/an/an/a 167n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400043
PNG
(N-(3-chloro-4-fluorophenyl)-6-methyl-7-(2-((3-meth...)
Show SMILES Cc1c(C(=O)C(=O)NC2(C)CS(=O)(=O)C2)c2CCCn2c1C(=O)Nc1ccc(F)c(c1)C#N
Show InChI InChI=1S/C22H21FN4O5S/c1-12-17(19(28)21(30)26-22(2)10-33(31,32)11-22)16-4-3-7-27(16)18(12)20(29)25-14-5-6-15(23)13(8-14)9-24/h5-6,8H,3-4,7,10-11H2,1-2H3,(H,25,29)(H,26,30)
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n/an/an/an/a 20.1n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400045
PNG
(US10328053, Compound 23)
Show SMILES CNC(=O)C1(CC(F)(F)C1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(Cl)c2)n2[C@@H](C)CCc12
Show InChI InChI=1S/C24H24ClF3N4O4/c1-11-4-7-16-17(19(33)21(35)31-23(22(36)29-3)9-24(27,28)10-23)12(2)18(32(11)16)20(34)30-13-5-6-15(26)14(25)8-13/h5-6,8,11H,4,7,9-10H2,1-3H3,(H,29,36)(H,30,34)(H,31,35)/t11-/m0/s1
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n/an/an/an/a 66n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400049
PNG
(N-(3-chloro-4-fluorophenyl)-7-(2-((3,3-difluoro-1-...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)C(=O)N2CC3(COC3)C2)c2CCCn2c1C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C27H26ClF3N4O5/c1-14-19(18-3-2-6-35(18)20(14)22(37)32-15-4-5-17(29)16(28)7-15)21(36)23(38)33-26(8-27(30,31)9-26)24(39)34-10-25(11-34)12-40-13-25/h4-5,7H,2-3,6,8-13H2,1H3,(H,32,37)(H,33,38)
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n/an/an/an/a 32.3n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400051
PNG
(N-(3-chloro-4-fluorophenyl)-7-(2-((3,3-difluoro-1-...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)c2c[nH]nn2)c2CCCn2c1C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C23H20ClF3N6O3/c1-11-17(19(34)21(36)30-22(9-23(26,27)10-22)16-8-28-32-31-16)15-3-2-6-33(15)18(11)20(35)29-12-4-5-14(25)13(24)7-12/h4-5,7-8H,2-3,6,9-10H2,1H3,(H,29,35)(H,30,36)(H,28,31,32)
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n/an/an/an/a 3.10n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400064
PNG
((1aR,6aR)-5-(2-((3,3-difluoro-1-(1H-1,2,3-triazol-...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)c2c[nH]nn2)c2C[C@H]3C[C@H]3n2c1C(=O)Nc1ccc(F)c(F)c1
Show InChI InChI=1/C24H20F4N6O3/c1-10-18(20(35)22(37)31-23(8-24(27,28)9-23)17-7-29-33-32-17)16-5-11-4-15(11)34(16)19(10)21(36)30-12-2-3-13(25)14(26)6-12/h2-3,6-7,11,15H,4-5,8-9H2,1H3,(H,30,36)(H,31,37)(H,29,32,33)/t11-,15-/s2
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n/an/an/an/a 2.10n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400065
PNG
(7-(2-((1-(1H-1,2,3-triazol-4-yl)cyclopropyl)amino)...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2c[nH]nn2)c2CCCn2c1C(=O)Nc1ccc(F)c(F)c1
Show InChI InChI=1S/C22H20F2N6O3/c1-11-17(19(31)21(33)27-22(6-7-22)16-10-25-29-28-16)15-3-2-8-30(15)18(11)20(32)26-12-4-5-13(23)14(24)9-12/h4-5,9-10H,2-3,6-8H2,1H3,(H,26,32)(H,27,33)(H,25,28,29)
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n/an/an/an/a 23.2n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400067
PNG
((R)-7-(2-((1-(1H-1,2,3-triazol-4-yl)cyclopropyl)am...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2c[nH]nn2)c2C[C@@H](F)Cn2c1C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1/C22H19ClF2N6O3/c1-10-17(19(32)21(34)28-22(4-5-22)16-8-26-30-29-16)15-6-11(24)9-31(15)18(10)20(33)27-12-2-3-14(25)13(23)7-12/h2-3,7-8,11H,4-6,9H2,1H3,(H,27,33)(H,28,34)(H,26,29,30)/t11-/s2
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n/an/an/an/a 9.10n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400071
PNG
((R)-7-(2-((3,3-difluoro-1-(methylcarbamoyl)cyclobu...)
Show SMILES CNC(=O)C1(CC(F)(F)C1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(F)c2)n2C[C@H](F)Cc12
Show InChI InChI=1S/C23H21F5N4O4/c1-10-16(18(33)20(35)31-22(21(36)29-2)8-23(27,28)9-22)15-5-11(24)7-32(15)17(10)19(34)30-12-3-4-13(25)14(26)6-12/h3-4,6,11H,5,7-9H2,1-2H3,(H,29,36)(H,30,34)(H,31,35)/t11-/m1/s1
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n/an/an/an/a 69.1n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400072
PNG
(N-(3-chloro-4-fluorophenyl)-6-methyl-7-(2-((1-(2-m...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2nnn(C)n2)c2CCCn2c1C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C22H21ClFN7O3/c1-11-16(18(32)20(34)26-22(7-8-22)21-27-29-30(2)28-21)15-4-3-9-31(15)17(11)19(33)25-12-5-6-14(24)13(23)10-12/h5-6,10H,3-4,7-9H2,1-2H3,(H,25,33)(H,26,34)
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n/an/an/an/a 53.7n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400086
PNG
(N-(3-chloro-4-fluorophenyl)-6-methyl-7-(2-((1-(5-m...)
Show SMILES Cc1nnc(o1)C1(CC1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(Cl)c2)n2CCCc12
Show InChI InChI=1S/C23H21ClFN5O4/c1-11-17(19(31)21(33)27-23(7-8-23)22-29-28-12(2)34-22)16-4-3-9-30(16)18(11)20(32)26-13-5-6-15(25)14(24)10-13/h5-6,10H,3-4,7-9H2,1-2H3,(H,26,32)(H,27,33)
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n/an/an/an/a 30.1n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400088
PNG
(N-(3-chloro-4-fluorophenyl)-6-methyl-7-(2-oxo-2-((...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2ccccc2)c2CCCn2c1C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C26H23ClFN3O3/c1-15-21(23(32)25(34)30-26(11-12-26)16-6-3-2-4-7-16)20-8-5-13-31(20)22(15)24(33)29-17-9-10-19(28)18(27)14-17/h2-4,6-7,9-10,14H,5,8,11-13H2,1H3,(H,29,33)(H,30,34)
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n/an/an/an/a 6.5n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400095
PNG
((1aR,6aR)-4-methyl-5-(2-((3-methyl-1,1-dioxidothie...)
Show SMILES Cc1c(C(=O)C(=O)NC2(C)CS(=O)(=O)C2)c2C[C@H]3C[C@H]3n2c1C(=O)Nc1cc(F)c(F)c(F)c1
Show InChI InChI=1S/C22H20F3N3O5S/c1-9-16(19(29)21(31)27-22(2)7-34(32,33)8-22)15-4-10-3-14(10)28(15)18(9)20(30)26-11-5-12(23)17(25)13(24)6-11/h5-6,10,14H,3-4,7-8H2,1-2H3,(H,26,30)(H,27,31)/t10-,14-/m1/s1
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n/an/an/an/a 15.8n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400102
PNG
((1aR,6aR)-5-(2-((3,3-difluoro-1-(1H-1,2,3-triazol-...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)c2c[nH]nn2)c2CC3C[C@H]3n2c1C(=O)Nc1ccnc(C(F)F)c1F
Show InChI InChI=1/C24H20F5N7O3/c1-9-15(19(37)22(39)33-23(7-24(28,29)8-23)14-6-31-35-34-14)13-5-10-4-12(10)36(13)18(9)21(38)32-11-2-3-30-17(16(11)25)20(26)27/h2-3,6,10,12,20H,4-5,7-8H2,1H3,(H,33,39)(H,30,32,38)(H,31,34,35)/t10?,12-/s2
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n/an/an/an/a 8.70n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400131
PNG
(7-(2-((3-cyanobicyclo[1.1.1]pentan-1-yl)amino)-2-o...)
Show SMILES Cc1c(C(=O)C(=O)NC23CC(C2)(C3)C#N)c2CCCn2c1C(=O)Nc1ccc(F)c(F)c1
Show InChI InChI=1S/C23H20F2N4O3/c1-12-17(19(30)21(32)28-23-8-22(9-23,10-23)11-26)16-3-2-6-29(16)18(12)20(31)27-13-4-5-14(24)15(25)7-13/h4-5,7H,2-3,6,8-10H2,1H3,(H,27,31)(H,28,32)
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n/an/an/an/a 45.1n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400134
PNG
(7-(2-((3,3-difluoro-1-(methylcarbamoyl)cyclobutyl)...)
Show SMILES CNC(=O)C1(CC(F)(F)C1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(c2)C(F)F)n2CCCc12
Show InChI InChI=1S/C24H23F5N4O4/c1-11-16(18(34)21(36)32-23(22(37)30-2)9-24(28,29)10-23)15-4-3-7-33(15)17(11)20(35)31-12-5-6-14(25)13(8-12)19(26)27/h5-6,8,19H,3-4,7,9-10H2,1-2H3,(H,30,37)(H,31,35)(H,32,36)
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n/an/an/an/a 24.2n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400143
PNG
(N-(3-chloro-2,4-difluorophenyl)-7-(2-((3,3-difluor...)
Show SMILES CNC(=O)C1(CC(F)(F)C1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(Cl)c2F)n2CCCc12
Show InChI InChI=1S/C23H21ClF4N4O4/c1-10-14(18(33)20(35)31-22(21(36)29-2)8-23(27,28)9-22)13-4-3-7-32(13)17(10)19(34)30-12-6-5-11(25)15(24)16(12)26/h5-6H,3-4,7-9H2,1-2H3,(H,29,36)(H,30,34)(H,31,35)
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n/an/an/an/a 32.3n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400148
PNG
((R)-N-(3-Chloro-4-fluorophenyl)-6-methyl-7-(2-oxo-...)
Show SMILES Cc1c(C(=O)C(=O)NC(C)(CO)C(F)(F)F)c2CCCn2c1C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C21H20ClF4N3O4/c1-10-15(17(31)19(33)28-20(2,9-30)21(24,25)26)14-4-3-7-29(14)16(10)18(32)27-11-5-6-13(23)12(22)8-11/h5-6,8,30H,3-4,7,9H2,1-2H3,(H,27,32)(H,28,33)
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n/an/an/an/a 8.30n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400156
PNG
(N-(3,4-difluorophenyl)-6-methyl-7-(2-((3-methyl-1-...)
Show SMILES Cc1c(C(=O)C(=O)NC2(C)CS(=O)C2)c2CCCn2c1C(=O)Nc1ccc(F)c(F)c1
Show InChI InChI=1S/C21H21F2N3O4S/c1-11-16(18(27)20(29)25-21(2)9-31(30)10-21)15-4-3-7-26(15)17(11)19(28)24-12-5-6-13(22)14(23)8-12/h5-6,8H,3-4,7,9-10H2,1-2H3,(H,24,28)(H,25,29)
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n/an/an/an/a 46.3n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM399986
PNG
(7-(2-(tert-Butylamino)-2-oxoacetyl)-6-chloro-N-(3-...)
Show SMILES CC(NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(Cl)c2)n2CCCc12)C(F)(F)F
Show InChI InChI=1S/C20H18ClF4N3O3/c1-9-15(17(29)19(31)26-10(2)20(23,24)25)14-4-3-7-28(14)16(9)18(30)27-11-5-6-13(22)12(21)8-11/h5-6,8,10H,3-4,7H2,1-2H3,(H,26,31)(H,27,30)
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n/an/an/an/a 27.1n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400031
PNG
(7-(2-((1-((2-oxa-6-azaspiro[3.3]heptan-6-yl)methyl...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CN3CC4(COC4)C3)CC(F)(F)C2)c2CCCn2c1C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C27H28ClF3N4O4/c1-15-20(19-3-2-6-35(19)21(15)23(37)32-16-4-5-18(29)17(28)7-16)22(36)24(38)33-26(8-27(30,31)9-26)12-34-10-25(11-34)13-39-14-25/h4-5,7H,2-3,6,8-14H2,1H3,(H,32,37)(H,33,38)
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n/an/an/an/a 56.1n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400058
PNG
(7-(2-((3,3-difluoro-1-(methylcarbamoyl)cyclobutyl)...)
Show SMILES CNC(=O)C1(CC(F)(F)C1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2cc(F)c(F)c(F)c2)n2CCCc12
Show InChI InChI=1S/C23H21F5N4O4/c1-10-15(18(33)20(35)31-22(21(36)29-2)8-23(27,28)9-22)14-4-3-5-32(14)17(10)19(34)30-11-6-12(24)16(26)13(25)7-11/h6-7H,3-5,8-9H2,1-2H3,(H,29,36)(H,30,34)(H,31,35)
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n/an/an/an/a 24n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400059
PNG
(N-(3-cyano-4-fluorophenyl)-7-(2-((3,3-difluoro-1-(...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)c2c[nH]nn2)c2CCCn2c1C(=O)Nc1ccc(F)c(c1)C#N
Show InChI InChI=1S/C24H20F3N7O3/c1-12-18(20(35)22(37)31-23(10-24(26,27)11-23)17-9-29-33-32-17)16-3-2-6-34(16)19(12)21(36)30-14-4-5-15(25)13(7-14)8-28/h4-5,7,9H,2-3,6,10-11H2,1H3,(H,30,36)(H,31,37)(H,29,32,33)
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n/an/an/an/a 5.60n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400077
PNG
(7-(2-((3,3-difluoro-1-(1H-1,2,3-triazol-4-yl)cyclo...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)c2c[nH]nn2)c2CCCn2c1C(=O)Nc1ccnc(c1)C(F)F
Show InChI InChI=1S/C23H21F4N7O3/c1-11-16(18(35)21(37)31-22(9-23(26,27)10-22)15-8-29-33-32-15)14-3-2-6-34(14)17(11)20(36)30-12-4-5-28-13(7-12)19(24)25/h4-5,7-8,19H,2-3,6,9-10H2,1H3,(H,31,37)(H,28,30,36)(H,29,32,33)
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n/an/an/an/a 54.3n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400097
PNG
(7-(2-((1-(1H-1,2,3-triazol-4-yl)cyclopropyl)amino)...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2c[nH]nn2)c2CCCn2c1C(=O)Nc1cccc(c1)C#N
Show InChI InChI=1S/C23H21N7O3/c1-13-18(20(31)22(33)27-23(7-8-23)17-12-25-29-28-17)16-6-3-9-30(16)19(13)21(32)26-15-5-2-4-14(10-15)11-24/h2,4-5,10,12H,3,6-9H2,1H3,(H,26,32)(H,27,33)(H,25,28,29)
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n/an/an/an/a 106n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400106
PNG
(7-(2-((1-(1H-1,2,3-triazol-5-yl)cyclopropyl)amino)...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2cnn[nH]2)c2CCCn2c1C(=O)Nc1ccc(F)c(Cl)c1F
Show InChI InChI=1S/C22H19ClF2N6O3/c1-10-15(19(32)21(34)28-22(6-7-22)14-9-26-30-29-14)13-3-2-8-31(13)18(10)20(33)27-12-5-4-11(24)16(23)17(12)25/h4-5,9H,2-3,6-8H2,1H3,(H,27,33)(H,28,34)(H,26,29,30)
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n/an/an/an/a 31n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400109
PNG
((1aR,6aR)-5-(2-((3-(1H-1,2,3-triazol-4-yl)oxetan-3...)
Show SMILES Cc1c(C(=O)C(=O)NC2(COC2)c2cn(COC(=O)C(C)(C)C)nn2)c2C[C@H]3C[C@H]3n2c1C(=O)Nc1ccc(F)c(F)c1
Show InChI InChI=1S/C29H30F2N6O6/c1-14-22(20-8-15-7-19(15)37(20)23(14)25(39)32-16-5-6-17(30)18(31)9-16)24(38)26(40)33-29(11-42-12-29)21-10-36(35-34-21)13-43-27(41)28(2,3)4/h5-6,9-10,15,19H,7-8,11-13H2,1-4H3,(H,32,39)(H,33,40)/t15-,19-/m1/s1
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n/an/an/an/a 12.5n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400112
PNG
(7-(2-((1-(1H-1,2,3-triazol-4-yl)cyclopropyl)amino)...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2c[nH]nn2)c2CCCn2c1C(=O)Nc1cc(F)c(F)cc1F
Show InChI InChI=1S/C22H19F3N6O3/c1-10-17(19(32)21(34)28-22(4-5-22)16-9-26-30-29-16)15-3-2-6-31(15)18(10)20(33)27-14-8-12(24)11(23)7-13(14)25/h7-9H,2-6H2,1H3,(H,27,33)(H,28,34)(H,26,29,30)
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n/an/an/an/a 183n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400113
PNG
(7-(2-((1-(1H-1,2,3-triazol-4-yl)cyclopropyl)amino)...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2c[nH]nn2)c2CCCn2c1C(=O)Nc1cc(Cl)c(F)cc1F
Show InChI InChI=1S/C22H19ClF2N6O3/c1-10-17(19(32)21(34)28-22(4-5-22)16-9-26-30-29-16)15-3-2-6-31(15)18(10)20(33)27-14-7-11(23)12(24)8-13(14)25/h7-9H,2-6H2,1H3,(H,27,33)(H,28,34)(H,26,29,30)
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n/an/an/an/a 91.1n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400118
PNG
((1aR,6aR)-5-(2-((3,3-difluoro-1-(methylcarbamoyl)c...)
Show SMILES CNC(=O)C1(CC(F)(F)C1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(F)c2)n2[C@@H]3C[C@@H]3Cc12
Show InChI InChI=1S/C24H22F4N4O4/c1-10-17(19(33)21(35)31-23(22(36)29-2)8-24(27,28)9-23)16-6-11-5-15(11)32(16)18(10)20(34)30-12-3-4-13(25)14(26)7-12/h3-4,7,11,15H,5-6,8-9H2,1-2H3,(H,29,36)(H,30,34)(H,31,35)/t11-,15-/m1/s1
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n/an/an/an/a 16.5n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400124
PNG
(7-(2-((1-(1H-1,2,3-triazol-4-yl)cyclopropyl)amino)...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2c[nH]nn2)c2CCCn2c1C(=O)Nc1cccc(c1)C(F)F
Show InChI InChI=1S/C23H22F2N6O3/c1-12-17(19(32)22(34)28-23(7-8-23)16-11-26-30-29-16)15-6-3-9-31(15)18(12)21(33)27-14-5-2-4-13(10-14)20(24)25/h2,4-5,10-11,20H,3,6-9H2,1H3,(H,27,33)(H,28,34)(H,26,29,30)
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n/an/an/an/a 40.8n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400140
PNG
(N-(3-chloro-4-fluorophenyl)-7-(2-((1-(dimethylcarb...)
Show SMILES CN(C)C(=O)C1(CC(F)(F)C1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(Cl)c2)n2CCCc12
Show InChI InChI=1S/C24H24ClF3N4O4/c1-12-17(19(33)21(35)30-23(22(36)31(2)3)10-24(27,28)11-23)16-5-4-8-32(16)18(12)20(34)29-13-6-7-15(26)14(25)9-13/h6-7,9H,4-5,8,10-11H2,1-3H3,(H,29,34)(H,30,35)
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n/an/an/an/a 11.9n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400155
PNG
(7-(2-((1-carbamoyl-3,3-difluorocyclobutyl)amino)-2...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)C(N)=O)c2CCCn2c1C(=O)Nc1cc(F)c(F)c(F)c1
Show InChI InChI=1S/C22H19F5N4O4/c1-9-14(17(32)19(34)30-21(20(28)35)7-22(26,27)8-21)13-3-2-4-31(13)16(9)18(33)29-10-5-11(23)15(25)12(24)6-10/h5-6H,2-4,7-8H2,1H3,(H2,28,35)(H,29,33)(H,30,34)
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n/an/an/an/a 12.2n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400158
PNG
((R)-N-(2-(difluoromethyl)-3-fluoropyridin-4-yl)-2-...)
Show SMILES Cc1c(C(=O)C(=O)NC2(COC2)C(F)(F)F)c2C[C@@H](F)Cn2c1C(=O)Nc1ccnc(C(F)F)c1F
Show InChI InChI=1S/C21H17F7N4O4/c1-8-12(16(33)19(35)31-20(6-36-7-20)21(26,27)28)11-4-9(22)5-32(11)15(8)18(34)30-10-2-3-29-14(13(10)23)17(24)25/h2-3,9,17H,4-7H2,1H3,(H,31,35)(H,29,30,34)/t9-/m1/s1
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n/an/an/an/a 74.3n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400028
PNG
(N-(3-chloro-4-fluorophenyl)-6-methyl-7-(2-oxo-2-((...)
Show SMILES Cc1c(C(=O)C(=O)NC2(COC2)C(F)(F)F)c2CCCn2c1C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C21H18ClF4N3O4/c1-10-15(17(30)19(32)28-20(8-33-9-20)21(24,25)26)14-3-2-6-29(14)16(10)18(31)27-11-4-5-13(23)12(22)7-11/h4-5,7H,2-3,6,8-9H2,1H3,(H,27,31)(H,28,32)
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n/an/an/an/a 5.80n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400032
PNG
(N-(3-chloro-4-fluorophenyl)-7-(2-((3,3-difluoro-1-...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)C(=O)N2CCC22COC2)c2CCCn2c1C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C27H26ClF3N4O5/c1-14-19(18-3-2-7-34(18)20(14)22(37)32-15-4-5-17(29)16(28)9-15)21(36)23(38)33-26(10-27(30,31)11-26)24(39)35-8-6-25(35)12-40-13-25/h4-5,9H,2-3,6-8,10-13H2,1H3,(H,32,37)(H,33,38)
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n/an/an/an/a 7.70n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400042
PNG
(N-(3-chloro-4-fluorophenyl)-3,6-dimethyl-7-(2-oxo-...)
Show SMILES C[C@@H](NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(Cl)c2)n2C(C)CCc12)C(F)(F)F
Show InChI InChI=1S/C21H20ClF4N3O3/c1-9-4-7-15-16(18(30)20(32)27-11(3)21(24,25)26)10(2)17(29(9)15)19(31)28-12-5-6-14(23)13(22)8-12/h5-6,8-9,11H,4,7H2,1-3H3,(H,27,32)(H,28,31)/t9?,11-/m1/s1
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n/an/an/an/a 49.4n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400066
PNG
(7-(2-((3,3-difluoro-1-(methylcarbamoyl)cyclobutyl)...)
Show SMILES CNC(=O)C1(CC(F)(F)C1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(F)c2)n2CCCc12
Show InChI InChI=1S/C23H22F4N4O4/c1-11-16(18(32)20(34)30-22(21(35)28-2)9-23(26,27)10-22)15-4-3-7-31(15)17(11)19(33)29-12-5-6-13(24)14(25)8-12/h5-6,8H,3-4,7,9-10H2,1-2H3,(H,28,35)(H,29,33)(H,30,34)
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n/an/an/an/a 31n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400079
PNG
((1aR,6aR)-5-(2-((1-(1,3,4-thiadiazol-2-yl)cyclopro...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2nncs2)c2C[C@H]3C[C@H]3n2c1C(=O)Nc1cc(F)c(F)c(F)c1
Show InChI InChI=1S/C23H18F3N5O3S/c1-9-16(19(32)21(34)29-23(2-3-23)22-30-27-8-35-22)15-5-10-4-14(10)31(15)18(9)20(33)28-11-6-12(24)17(26)13(25)7-11/h6-8,10,14H,2-5H2,1H3,(H,28,33)(H,29,34)/t10-,14-/m1/s1
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n/an/an/an/a 9.90n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400081
PNG
(7-(2-((3,3-difluoro-1-(1H-1,2,3-triazol-4-yl)cyclo...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)c2c[nH]nn2)c2CCCn2c1C(=O)Nc1ccnc(C(F)F)c1F
Show InChI InChI=1S/C23H20F5N7O3/c1-10-14(18(36)21(38)32-22(8-23(27,28)9-22)13-7-30-34-33-13)12-3-2-6-35(12)17(10)20(37)31-11-4-5-29-16(15(11)24)19(25)26/h4-5,7,19H,2-3,6,8-9H2,1H3,(H,32,38)(H,29,31,37)(H,30,33,34)
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n/an/an/an/a 23.8n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400093
PNG
((1aR,6aR)-N-(3-chloro-4-fluorophenyl)-4-methyl-5-(...)
Show SMILES Cc1c(C(=O)C(=O)NC2(C)CS(=O)(=O)C2)c2C[C@H]3C[C@H]3n2c1C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C22H21ClFN3O5S/c1-10-17(19(28)21(30)26-22(2)8-33(31,32)9-22)16-6-11-5-15(11)27(16)18(10)20(29)25-12-3-4-14(24)13(23)7-12/h3-4,7,11,15H,5-6,8-9H2,1-2H3,(H,25,29)(H,26,30)/t11-,15-/m1/s1
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US Patent
n/an/an/an/a 15.4n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400104
PNG
(N-(3-chloro-4-fluorophenyl)-6-methyl-7-(2-((2-meth...)
Show SMILES CNC(=O)C(C)(C)NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)c(Cl)c2)n2CCCc12
Show InChI InChI=1S/C22H24ClFN4O4/c1-11-16(18(29)20(31)27-22(2,3)21(32)25-4)15-6-5-9-28(15)17(11)19(30)26-12-7-8-14(24)13(23)10-12/h7-8,10H,5-6,9H2,1-4H3,(H,25,32)(H,26,30)(H,27,31)
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n/an/an/an/a 133n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400119
PNG
(N-(3-chloro-4-fluorophenyl)-6-methyl-7-(2-((1-(1-m...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2cn(C)nn2)c2CCCn2c1C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C23H22ClFN6O3/c1-12-18(20(32)22(34)27-23(7-8-23)17-11-30(2)29-28-17)16-4-3-9-31(16)19(12)21(33)26-13-5-6-15(25)14(24)10-13/h5-6,10-11H,3-4,7-9H2,1-2H3,(H,26,33)(H,27,34)
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n/an/an/an/a 30.6n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400122
PNG
(7-(2-((1-(1H-1,2,3-triazol-4-yl)cyclopropyl)amino)...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC2)c2c[nH]nn2)c2CCCn2c1C(=O)Nc1cc(F)cc(Cl)c1
Show InChI InChI=1S/C22H20ClFN6O3/c1-11-17(19(31)21(33)27-22(4-5-22)16-10-25-29-28-16)15-3-2-6-30(15)18(11)20(32)26-14-8-12(23)7-13(24)9-14/h7-10H,2-6H2,1H3,(H,26,32)(H,27,33)(H,25,28,29)
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n/an/an/an/a 29.8n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400137
PNG
((1aR,6aR)-N-(2-(difluoromethyl)pyridin-4-yl)-4-met...)
Show SMILES Cc1c(C(=O)C(=O)NC2(COC2)C(F)(F)F)c2C[C@H]3C[C@H]3n2c1C(=O)Nc1ccnc(c1)C(F)F
Show InChI InChI=1S/C22H19F5N4O4/c1-9-15(17(32)20(34)30-21(7-35-8-21)22(25,26)27)14-5-10-4-13(10)31(14)16(9)19(33)29-11-2-3-28-12(6-11)18(23)24/h2-3,6,10,13,18H,4-5,7-8H2,1H3,(H,30,34)(H,28,29,33)/t10-,13-/m1/s1
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n/an/an/an/a 25.8n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400146
PNG
(N-(3-chloro-4-fluorophenyl)-7-(2-((1-cyano-3,3-dif...)
Show SMILES Cc1c(C(=O)C(=O)NC2(CC(F)(F)C2)C#N)c2CCCn2c1C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C22H18ClF3N4O3/c1-11-16(18(31)20(33)29-21(10-27)8-22(25,26)9-21)15-3-2-6-30(15)17(11)19(32)28-12-4-5-14(24)13(23)7-12/h4-5,7H,2-3,6,8-9H2,1H3,(H,28,32)(H,29,33)
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n/an/an/an/a 10.4n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
Bile acid transporter


(Homo sapiens (Human))
BDBM400159
PNG
(N-(3,4-difluorophenyl)-6-methyl-7-(2-(((1r,3r)-3-m...)
Show SMILES Cc1c(C(=O)C(=O)N[C@@]2(C)C[S@](=O)C2)c2CCCn2c1C(=O)Nc1ccc(F)c(F)c1
Show InChI InChI=1S/C21H21F2N3O4S/c1-11-16(18(27)20(29)25-21(2)9-31(30)10-21)15-4-3-7-26(15)17(11)19(28)24-12-5-6-13(22)14(23)8-12/h5-6,8H,3-4,7,9-10H2,1-2H3,(H,24,28)(H,25,29)/t21-,31-
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n/an/an/an/a 30.6n/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...


US Patent US10328053 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%