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Patent code US10328054

Compile Data Set for Download or QSAR
Found 69 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400162
PNG
(Procedure for Preparation of 1-ethynyl-3-azabicycl...)
Show SMILES Fc1ccc(cc1)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C18H15FN2/c19-15-4-6-17(7-5-15)21-12-14-11-18(14,13-21)9-8-16-3-1-2-10-20-16/h1-7,10,14H,11-13H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400196
PNG
(US10328054, Example Compound 34)
Show SMILES Clc1cccc(c1)S(=O)(=O)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C18H15ClN2O2S/c19-15-4-3-6-17(10-15)24(22,23)21-12-14-11-18(14,13-21)8-7-16-5-1-2-9-20-16/h1-6,9-10,14H,11-13H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400200
PNG
(US10328054, Example Compound 41)
Show SMILES Fc1cccc(c1)C(=O)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C19H15FN2O/c20-16-5-3-4-14(10-16)18(23)22-12-15-11-19(15,13-22)8-7-17-6-1-2-9-21-17/h1-6,9-10,15H,11-13H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400216
PNG
(US10328054, Example Compound 69)
Show SMILES Cc1nc(cs1)C#CC12CC1CN(C2)C(=O)C(C)(C)C
Show InChI InChI=1S/C16H20N2OS/c1-11-17-13(9-20-11)5-6-16-7-12(16)8-18(10-16)14(19)15(2,3)4/h9,12H,7-8,10H2,1-4H3
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400218
PNG
(US10328054, Example Compound 58)
Show SMILES CCCNC(=O)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C16H19N3O/c1-2-8-18-15(20)19-11-13-10-16(13,12-19)7-6-14-5-3-4-9-17-14/h3-5,9,13H,2,8,10-12H2,1H3,(H,18,20)
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400224
PNG
(US10328054, Example Compound 11)
Show SMILES Fc1cc(cc(c1)N1CC2CC2(C1)C#Cc1cccnn1)C#N
Show InChI InChI=1S/C18H13FN4/c19-15-6-13(10-20)7-17(8-15)23-11-14-9-18(14,12-23)4-3-16-2-1-5-21-22-16/h1-2,5-8,14H,9,11-12H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400183
PNG
(US10328054, Example Compound 38)
Show SMILES N#Cc1cccc(n1)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C18H14N4/c19-11-16-5-3-6-17(21-16)22-12-14-10-18(14,13-22)8-7-15-4-1-2-9-20-15/h1-6,9,14H,10,12-13H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400191
PNG
(US10328054, Example Compound 29)
Show SMILES O=C(Cc1ccccc1)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C20H18N2O/c23-19(12-16-6-2-1-3-7-16)22-14-17-13-20(17,15-22)10-9-18-8-4-5-11-21-18/h1-8,11,17H,12-15H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400202
PNG
(US10328054, Example Compound 44)
Show SMILES Cc1cccc(n1)C#CC12CC1CN(C2)C(=O)c1cccc(F)c1
Show InChI InChI=1S/C20H17FN2O/c1-14-4-2-7-18(22-14)8-9-20-11-16(20)12-23(13-20)19(24)15-5-3-6-17(21)10-15/h2-7,10,16H,11-13H2,1H3
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400205
PNG
(US10328054, Example Compound 52)
Show SMILES CC(C)(C)C(=O)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C17H20N2O/c1-16(2,3)15(20)19-11-13-10-17(13,12-19)8-7-14-6-4-5-9-18-14/h4-6,9,13H,10-12H2,1-3H3
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400161
PNG
(Preparation of tert-butyl 1-ethynyl-3-azabicyclo[3...)
Show SMILES Fc1cc(cc(c1)N1CC2CC2(C1)C#Cc1ccccn1)C#N
Show InChI InChI=1S/C19H14FN3/c20-16-7-14(11-21)8-18(9-16)23-12-15-10-19(15,13-23)5-4-17-3-1-2-6-22-17/h1-3,6-9,15H,10,12-13H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400177
PNG
(US10328054, Example Compound 62)
Show SMILES N#Cc1cccc(c1)N1CC2CC2(C1)C#Cc1ncccn1
Show InChI InChI=1S/C18H14N4/c19-11-14-3-1-4-16(9-14)22-12-15-10-18(15,13-22)6-5-17-20-7-2-8-21-17/h1-4,7-9,15H,10,12-13H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400180
PNG
(US10328054, Example Compound 23)
Show SMILES N#Cc1ccnc(c1)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C18H14N4/c19-11-14-5-8-21-17(9-14)22-12-15-10-18(15,13-22)6-4-16-3-1-2-7-20-16/h1-3,5,7-9,15H,10,12-13H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400185
PNG
(US10328054, Example Compound 50)
Show SMILES N#Cc1cncc(c1)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C18H14N4/c19-9-14-7-17(11-20-10-14)22-12-15-8-18(15,13-22)5-4-16-3-1-2-6-21-16/h1-3,6-7,10-11,15H,8,12-13H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400193
PNG
(US10328054, Example Compound 31)
Show SMILES CCCCC(=O)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C17H20N2O/c1-2-3-7-16(20)19-12-14-11-17(14,13-19)9-8-15-6-4-5-10-18-15/h4-6,10,14H,2-3,7,11-13H2,1H3
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400195
PNG
(US10328054, Example Compound 33)
Show SMILES Clc1ccc(cc1)C(=O)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C19H15ClN2O/c20-16-6-4-14(5-7-16)18(23)22-12-15-11-19(15,13-22)9-8-17-3-1-2-10-21-17/h1-7,10,15H,11-13H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400204
PNG
(US10328054, Example Compound 51)
Show SMILES O=C(C1CCCC1)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C18H20N2O/c21-17(14-5-1-2-6-14)20-12-15-11-18(15,13-20)9-8-16-7-3-4-10-19-16/h3-4,7,10,14-15H,1-2,5-6,11-13H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400211
PNG
(US10328054, Example Compound 64)
Show SMILES CC(C)C(=O)N1CC2CC2(C1)C#Cc1cccc(C)n1
Show InChI InChI=1S/C17H20N2O/c1-12(2)16(20)19-10-14-9-17(14,11-19)8-7-15-6-4-5-13(3)18-15/h4-6,12,14H,9-11H2,1-3H3
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400225
PNG
(US10328054, Example Compound 12)
Show SMILES Fc1cc(cc(c1)N1CC2CC2(C1)C#Cc1ccnc(Cl)c1)C#N
Show InChI InChI=1S/C19H13ClFN3/c20-18-7-13(2-4-23-18)1-3-19-9-15(19)11-24(12-19)17-6-14(10-22)5-16(21)8-17/h2,4-8,15H,9,11-12H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400164
PNG
(US10328054, Example Compound 10)
Show SMILES C1C2CN(CC12C#Cc1ccccn1)c1ccccc1
Show InChI InChI=1S/C18H16N2/c1-2-7-17(8-3-1)20-13-15-12-18(15,14-20)10-9-16-6-4-5-11-19-16/h1-8,11,15H,12-14H2
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Hua Medicine (Shanghai) Ltd.

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Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400165
PNG
(US10328054, Example Compound 16)
Show SMILES Fc1ccccc1N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C18H15FN2/c19-16-6-1-2-7-17(16)21-12-14-11-18(14,13-21)9-8-15-5-3-4-10-20-15/h1-7,10,14H,11-13H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400172
PNG
(US10328054, Example Compound 40)
Show SMILES N#Cc1cccc(c1)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C19H15N3/c20-12-15-4-3-6-18(10-15)22-13-16-11-19(16,14-22)8-7-17-5-1-2-9-21-17/h1-6,9-10,16H,11,13-14H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400173
PNG
(US10328054, Example Compound 45)
Show SMILES Fc1cc(F)cc(c1)N1CC2CC2(C1)C#Cc1ncccn1
Show InChI InChI=1S/C17H13F2N3/c18-13-6-14(19)8-15(7-13)22-10-12-9-17(12,11-22)3-2-16-20-4-1-5-21-16/h1,4-8,12H,9-11H2
PDB
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400179
PNG
(US10328054, Example Compound 6)
Show SMILES Fc1ccc(nc1)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C17H14FN3/c18-14-4-5-16(20-10-14)21-11-13-9-17(13,12-21)7-6-15-3-1-2-8-19-15/h1-5,8,10,13H,9,11-12H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400184
PNG
(US10328054, Example Compound 43)
Show SMILES Cc1cccc(n1)C#CC12CC1CN(C2)c1cncc(F)c1
Show InChI InChI=1S/C18H16FN3/c1-13-3-2-4-16(21-13)5-6-18-8-14(18)11-22(12-18)17-7-15(19)9-20-10-17/h2-4,7,9-10,14H,8,11-12H2,1H3
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400189
PNG
(US10328054, Example Compound 27)
Show SMILES O=C(N1CC2CC2(C1)C#Cc1ccccn1)c1ccccn1
Show InChI InChI=1S/C18H15N3O/c22-17(16-6-2-4-10-20-16)21-12-14-11-18(14,13-21)8-7-15-5-1-3-9-19-15/h1-6,9-10,14H,11-13H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400190
PNG
(US10328054, Example Compound 28)
Show SMILES O=C(N1CC2CC2(C1)C#Cc1ccccn1)c1ccccc1
Show InChI InChI=1S/C19H16N2O/c22-18(15-6-2-1-3-7-15)21-13-16-12-19(16,14-21)10-9-17-8-4-5-11-20-17/h1-8,11,16H,12-14H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400194
PNG
(US10328054, Example Compound 32)
Show SMILES O=C(CCc1ccccc1)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C21H20N2O/c24-20(10-9-17-6-2-1-3-7-17)23-15-18-14-21(18,16-23)12-11-19-8-4-5-13-22-19/h1-8,13,18H,9-10,14-16H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400198
PNG
(US10328054, Example Compound 36)
Show SMILES Clc1ccccc1S(=O)(=O)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C18H15ClN2O2S/c19-16-6-1-2-7-17(16)24(22,23)21-12-14-11-18(14,13-21)9-8-15-5-3-4-10-20-15/h1-7,10,14H,11-13H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400199
PNG
(US10328054, Example Compound 37)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C19H18N2O2S/c1-15-5-7-18(8-6-15)24(22,23)21-13-16-12-19(16,14-21)10-9-17-4-2-3-11-20-17/h2-8,11,16H,12-14H2,1H3
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400207
PNG
(US10328054, Example Compound 54)
Show SMILES Clc1cncc(c1)C(=O)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C18H14ClN3O/c19-15-7-13(9-20-10-15)17(23)22-11-14-8-18(14,12-22)5-4-16-3-1-2-6-21-16/h1-3,6-7,9-10,14H,8,11-12H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400214
PNG
(US10328054, Example Compound 67)
Show SMILES CCCCC(=O)N1CC2CC2(C1)C#Cc1csc(C)n1
Show InChI InChI=1S/C16H20N2OS/c1-3-4-5-15(19)18-9-13-8-16(13,11-18)7-6-14-10-20-12(2)17-14/h10,13H,3-5,8-9,11H2,1-2H3
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400219
PNG
(US10328054, Example Compound 59)
Show SMILES O=C(N1CCCC1)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C17H19N3O/c21-16(19-9-3-4-10-19)20-12-14-11-17(14,13-20)7-6-15-5-1-2-8-18-15/h1-2,5,8,14H,3-4,9-13H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400221
PNG
(US10328054, Example Compound 7)
Show SMILES Fc1cc(cc(c1)N1CC2CC2(C1)C#Cc1cnccn1)C#N
Show InChI InChI=1S/C18H13FN4/c19-15-5-13(9-20)6-17(7-15)23-11-14-8-18(14,12-23)2-1-16-10-21-3-4-22-16/h3-7,10,14H,8,11-12H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400229
PNG
(US10328054, Example Compound 39)
Show SMILES Cc1nc(cs1)C#CC12CC1CN(C2)c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C18H14FN3S/c1-12-21-16(10-23-12)2-3-18-7-14(18)9-22(11-18)17-5-13(8-20)4-15(19)6-17/h4-6,10,14H,7,9,11H2,1H3
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400166
PNG
(US10328054, Example Compound 17)
Show SMILES Clc1ccccc1N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C18H15ClN2/c19-16-6-1-2-7-17(16)21-12-14-11-18(14,13-21)9-8-15-5-3-4-10-20-15/h1-7,10,14H,11-13H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400174
PNG
(US10328054, Example Compound 46)
Show SMILES Fc1cccc(c1)N1CC2CC2(C1)C#Cc1ncccn1
Show InChI InChI=1S/C17H14FN3/c18-14-3-1-4-15(9-14)21-11-13-10-17(13,12-21)6-5-16-19-7-2-8-20-16/h1-4,7-9,13H,10-12H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400186
PNG
(US10328054, Example Compound 63)
Show SMILES Fc1cncc(c1)N1CC2CC2(C1)C#Cc1ncccn1
Show InChI InChI=1S/C16H13FN4/c17-13-6-14(9-18-8-13)21-10-12-7-16(12,11-21)3-2-15-19-4-1-5-20-15/h1,4-6,8-9,12H,7,10-11H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400187
PNG
(US10328054, Example Compound 5)
Show SMILES O=S(=O)(N1CC2CC2(C1)C#Cc1ccccn1)c1ccccc1
Show InChI InChI=1S/C18H16N2O2S/c21-23(22,17-7-2-1-3-8-17)20-13-15-12-18(15,14-20)10-9-16-6-4-5-11-19-16/h1-8,11,15H,12-14H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400192
PNG
(US10328054, Example Compound 30)
Show SMILES Clc1ccccc1C(=O)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C19H15ClN2O/c20-17-7-2-1-6-16(17)18(23)22-12-14-11-19(14,13-22)9-8-15-5-3-4-10-21-15/h1-7,10,14H,11-13H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400228
PNG
(US10328054, Example Compound 15)
Show SMILES COc1cccc(n1)C#CC12CC1CN(C2)c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C20H16FN3O/c1-25-19-4-2-3-17(23-19)5-6-20-10-15(20)12-24(13-20)18-8-14(11-22)7-16(21)9-18/h2-4,7-9,15H,10,12-13H2,1H3
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400175
PNG
(US10328054, Example Compound 47)
Show SMILES Cc1nc(cs1)C#CC12CC1CN(C2)c1cccc(c1)C#N
Show InChI InChI=1S/C18H15N3S/c1-13-20-16(11-22-13)5-6-18-8-15(18)10-21(12-18)17-4-2-3-14(7-17)9-19/h2-4,7,11,15H,8,10,12H2,1H3
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400178
PNG
(Preparation of 1-(pyridin-2-ylethynyl)-3-azabicycl...)
Show SMILES Fc1cncc(c1)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C17H14FN3/c18-14-7-16(10-19-9-14)21-11-13-8-17(13,12-21)5-4-15-3-1-2-6-20-15/h1-3,6-7,9-10,13H,8,11-12H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400188
PNG
(US10328054, Example Compound 26)
Show SMILES Clc1cccc(c1)C(=O)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C19H15ClN2O/c20-16-5-3-4-14(10-16)18(23)22-12-15-11-19(15,13-22)8-7-17-6-1-2-9-21-17/h1-6,9-10,15H,11-13H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400197
PNG
(US10328054, Example Compound 35)
Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C18H15ClN2O2S/c19-15-4-6-17(7-5-15)24(22,23)21-12-14-11-18(14,13-21)9-8-16-3-1-2-10-20-16/h1-7,10,14H,11-13H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400206
PNG
(US10328054, Example Compound 53)
Show SMILES COC(=O)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C14H14N2O2/c1-18-13(17)16-9-11-8-14(11,10-16)6-5-12-4-2-3-7-15-12/h2-4,7,11H,8-10H2,1H3
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400209
PNG
(US10328054, Example Compound 56)
Show SMILES Clc1ccc(cn1)C(=O)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C18H14ClN3O/c19-16-5-4-13(10-21-16)17(23)22-11-14-9-18(14,12-22)7-6-15-3-1-2-8-20-15/h1-5,8,10,14H,9,11-12H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400213
PNG
(US10328054, Example Compound 66)
Show SMILES Cc1nc(cs1)C#CC12CC1CN(C2)C(=O)c1ccccc1
Show InChI InChI=1S/C18H16N2OS/c1-13-19-16(11-22-13)7-8-18-9-15(18)10-20(12-18)17(21)14-5-3-2-4-6-14/h2-6,11,15H,9-10,12H2,1H3
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400167
PNG
(US10328054, Example Compound 18)
Show SMILES Clc1cccc(c1)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C18H15ClN2/c19-15-4-3-6-17(10-15)21-12-14-11-18(14,13-21)8-7-16-5-1-2-9-20-16/h1-6,9-10,14H,11-13H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400212
PNG
(US10328054, Example Compound 65)
Show SMILES CC(C)C(=O)N1CC2CC2(C1)C#Cc1cccc(Cl)n1
Show InChI InChI=1S/C16H17ClN2O/c1-11(2)15(20)19-9-12-8-16(12,10-19)7-6-13-4-3-5-14(17)18-13/h3-5,11-12H,8-10H2,1-2H3
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400220
PNG
(US10328054, Example Compound 60)
Show SMILES FC(F)(F)CNC(=O)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C15H14F3N3O/c16-15(17,18)9-20-13(22)21-8-11-7-14(11,10-21)5-4-12-3-1-2-6-19-12/h1-3,6,11H,7-10H2,(H,20,22)
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400222
PNG
(US10328054, Example Compound 8)
Show SMILES Fc1cc(cc(c1)N1CC2CC2(C1)C#Cc1ncccn1)C#N
Show InChI InChI=1S/C18H13FN4/c19-15-6-13(10-20)7-16(8-15)23-11-14-9-18(14,12-23)3-2-17-21-4-1-5-22-17/h1,4-8,14H,9,11-12H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400226
PNG
(US10328054, Example Compound 13)
Show SMILES Cc1cccc(n1)C#CC12CC1CN(C2)c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C20H16FN3/c1-14-3-2-4-18(23-14)5-6-20-10-16(20)12-24(13-20)19-8-15(11-22)7-17(21)9-19/h2-4,7-9,16H,10,12-13H2,1H3
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400169
PNG
(US10328054, Example Compound 20)
Show SMILES Fc1cc(Cl)cc(c1)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C18H14ClFN2/c19-14-7-15(20)9-17(8-14)22-11-13-10-18(13,12-22)5-4-16-3-1-2-6-21-16/h1-3,6-9,13H,10-12H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400176
PNG
(US10328054, Example Compound 48)
Show SMILES Cc1nc(cs1)C#CC12CC1CN(C2)c1cncc(F)c1
Show InChI InChI=1S/C16H14FN3S/c1-11-19-14(9-21-11)2-3-16-5-12(16)8-20(10-16)15-4-13(17)6-18-7-15/h4,6-7,9,12H,5,8,10H2,1H3
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400201
PNG
(US10328054, Example Compound 42)
Show SMILES Fc1ccccc1S(=O)(=O)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C18H15FN2O2S/c19-16-6-1-2-7-17(16)24(22,23)21-12-14-11-18(14,13-21)9-8-15-5-3-4-10-20-15/h1-7,10,14H,11-13H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400203
PNG
(US10328054, Example Compound 49)
Show SMILES Cc1nc(cs1)C#CC12CC1CN(C2)C(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C18H15ClN2OS/c1-12-20-16(10-23-12)5-6-18-8-14(18)9-21(11-18)17(22)13-3-2-4-15(19)7-13/h2-4,7,10,14H,8-9,11H2,1H3
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400208
PNG
(US10328054, Example Compound 55)
Show SMILES Clc1ccnc(c1)C(=O)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C18H14ClN3O/c19-14-5-8-21-16(9-14)17(23)22-11-13-10-18(13,12-22)6-4-15-3-1-2-7-20-15/h1-3,5,7-9,13H,10-12H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400215
PNG
(US10328054, Example Compound 68)
Show SMILES CC(C)C(=O)N1CC2CC2(C1)C#Cc1csc(C)n1
Show InChI InChI=1S/C15H18N2OS/c1-10(2)14(18)17-7-12-6-15(12,9-17)5-4-13-8-19-11(3)16-13/h8,10,12H,6-7,9H2,1-3H3
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400227
PNG
(US10328054, Example Compound 14)
Show SMILES Fc1cc(cc(c1)N1CC2CC2(C1)C#Cc1cccc(Cl)n1)C#N
Show InChI InChI=1S/C19H13ClFN3/c20-18-3-1-2-16(23-18)4-5-19-9-14(19)11-24(12-19)17-7-13(10-22)6-15(21)8-17/h1-3,6-8,14H,9,11-12H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400168
PNG
(US10328054, Example Compound 19)
Show SMILES Clc1ccc(cc1)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C18H15ClN2/c19-15-4-6-17(7-5-15)21-12-14-11-18(14,13-21)9-8-16-3-1-2-10-20-16/h1-7,10,14H,11-13H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400210
PNG
(US10328054, Example Compound 61)
Show SMILES Clc1cccc(c1)C(=O)N1CC2CC2(C1)C#Cc1ncccn1
Show InChI InChI=1S/C18H14ClN3O/c19-15-4-1-3-13(9-15)17(23)22-11-14-10-18(14,12-22)6-5-16-20-7-2-8-21-16/h1-4,7-9,14H,10-12H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400171
PNG
(US10328054, Example Compound 22)
Show SMILES Fc1cc(ccc1Cl)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C18H14ClFN2/c19-16-5-4-15(9-17(16)20)22-11-13-10-18(13,12-22)7-6-14-3-1-2-8-21-14/h1-5,8-9,13H,10-12H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400170
PNG
(US10328054, Example Compound 21)
Show SMILES Fc1cc(Cl)ccc1N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C18H14ClFN2/c19-14-4-5-17(16(20)9-14)22-11-13-10-18(13,12-22)7-6-15-3-1-2-8-21-15/h1-5,8-9,13H,10-12H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400217
PNG
(US10328054, Example Compound 57)
Show SMILES O=C(Nc1ccccc1)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C19H17N3O/c23-18(21-17-7-2-1-3-8-17)22-13-15-12-19(15,14-22)10-9-16-6-4-5-11-20-16/h1-8,11,15H,12-14H2,(H,21,23)
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400223
PNG
(US10328054, Example Compound 9)
Show SMILES Cc1cccnc1C#CC12CC1CN(C2)c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C20H16FN3/c1-14-3-2-6-23-19(14)4-5-20-10-16(20)12-24(13-20)18-8-15(11-22)7-17(21)9-18/h2-3,6-9,16H,10,12-13H2,1H3
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400163
PNG
(Preparation of 3-(1-ethynyl-3-azabicyclo[3.1.0]hex...)
Show SMILES FC(F)(F)Oc1ccc(cc1)N1CC2CC2(C1)C#Cc1ccccn1
Show InChI InChI=1S/C19H15F3N2O/c20-19(21,22)25-17-6-4-16(5-7-17)24-12-14-11-18(14,13-24)9-8-15-3-1-2-10-23-15/h1-7,10,14H,11-13H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400181
PNG
(US10328054, Example Compound 24)
Show SMILES C1C2CN(CC12C#Cc1ccccn1)c1ccc2[nH]ccc2n1
Show InChI InChI=1/C19H16N4/c1-2-9-20-15(3-1)6-8-19-11-14(19)12-23(13-19)18-5-4-16-17(22-18)7-10-21-16/h1-5,7,9-10,14,21H,11-13H2
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM400182
PNG
(US10328054, Example Compound 25)
Show SMILES C1C2CN(CC12C#Cc1ccccn1)c1ccc2[nH]cnc2c1
Show InChI InChI=1/C19H16N4/c1-2-8-20-15(3-1)6-7-19-10-14(19)11-23(12-19)16-4-5-17-18(9-16)22-13-21-17/h1-5,8-9,13-14H,10-12H2,(H,21,22)
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Hua Medicine (Shanghai) Ltd.

US Patent


Assay Description
For functional assays, HEK293 cells stably expressing recombinant rat mGluR5 were seeded in 384-well plates and dye loaded using Fluo-8. Cells were t...


US Patent US10328054 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%