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Patent code US10329282

Compile Data Set for Download or QSAR
Found 123 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402404
PNG
(US10329282, Compound TDI01433)
Show SMILES FC(F)(F)C1CN(C1)C(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-13-36(14-19)25(37)22-9-16-1-2-17(10-21(16)34-22)24-30-8-7-23(35-24)33-20-5-3-15(4-6-20)18-11-31-32-12-18/h1-12,19,34H,13-14H2,(H,31,32)(H,30,33,35)
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UniChem
US Patent
n/an/a 13n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402322
PNG
(US10329282, Compound TDI01153)
Show SMILES O=C(Nc1ccncc1)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C25H18N8O/c34-25(30-18-5-8-26-9-6-18)22-12-15-1-2-16(13-21(15)31-22)24-27-10-7-23(32-24)29-19-3-4-20-17(11-19)14-28-33-20/h1-14,31H,(H,28,33)(H,26,30,34)(H,27,29,32)
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PC sid
UniChem
US Patent
n/an/a 16n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402391
PNG
(US10329282, Compound TDI01398)
Show SMILES O=C(N1CC(C1)C#N)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C26H20N8O/c27-11-16-14-34(15-16)26(35)23-9-18-1-2-19(10-22(18)32-23)25-28-8-7-24(33-25)31-21-5-3-17(4-6-21)20-12-29-30-13-20/h1-10,12-13,16,32H,14-15H2,(H,29,30)(H,28,31,33)
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PC sid
UniChem
US Patent
n/an/a 16n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402367
PNG
(US10329282, Compound TDI01318)
Show SMILES CN1CCC(CC1)N1CCCC(C1)NC(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1/C31H35N9O/c1-39-13-9-25(10-14-39)40-12-2-3-24(19-40)35-31(41)28-16-20-4-5-21(17-27(20)36-28)30-32-11-8-29(37-30)34-23-6-7-26-22(15-23)18-33-38-26/h4-8,11,15-18,24-25,36H,2-3,9-10,12-14,19H2,1H3,(H,33,38)(H,35,41)(H,32,34,37)
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PC sid
UniChem
US Patent
n/an/a 18n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402298
PNG
(US10329282, Compound TDI01108)
Show SMILES CC(C)NC(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C23H21N7O/c1-13(2)26-23(31)20-10-14-3-4-15(11-19(14)28-20)22-24-8-7-21(29-22)27-17-5-6-18-16(9-17)12-25-30-18/h3-13,28H,1-2H3,(H,25,30)(H,26,31)(H,24,27,29)
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PC sid
UniChem
US Patent
n/an/a 22n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402339
PNG
(US10329282, Compound TDI01200)
Show SMILES CC(C)(C)OC(=O)n1cc(NC(=O)c2cc3ccc(cc3[nH]2)-c2nccc(Nc3ccc4[nH]ncc4c3)n2)cn1
Show InChI InChI=1S/C28H25N9O3/c1-28(2,3)40-27(39)37-15-20(14-31-37)33-26(38)23-11-16-4-5-17(12-22(16)34-23)25-29-9-8-24(35-25)32-19-6-7-21-18(10-19)13-30-36-21/h4-15,34H,1-3H3,(H,30,36)(H,33,38)(H,29,32,35)
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PC sid
UniChem
US Patent
n/an/a 23n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402323
PNG
(US10329282, Compound TDI01156)
Show SMILES O=C(Nc1cnoc1)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C23H16N8O2/c32-23(28-17-11-26-33-12-17)20-8-13-1-2-14(9-19(13)29-20)22-24-6-5-21(30-22)27-16-3-4-18-15(7-16)10-25-31-18/h1-12,29H,(H,25,31)(H,28,32)(H,24,27,30)
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PC sid
UniChem
US Patent
n/an/a 25n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402411
PNG
(US10329282, Compound TDI01847B)
Show SMILES Clc1cnccc1N1CCC(CC1)NC(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C32H28ClN9O/c33-26-19-34-11-7-29(26)42-13-9-25(10-14-42)39-32(43)28-15-21-1-2-22(16-27(21)40-28)31-35-12-8-30(41-31)38-24-5-3-20(4-6-24)23-17-36-37-18-23/h1-8,11-12,15-19,25,40H,9-10,13-14H2,(H,36,37)(H,39,43)(H,35,38,41)
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PC sid
UniChem
US Patent
n/an/a 26n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402330
PNG
(US10329282, Compound TDI01176)
Show SMILES CC(CO)NC(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1/C23H21N7O2/c1-13(12-31)26-23(32)20-9-14-2-3-15(10-19(14)28-20)22-24-7-6-21(29-22)27-17-4-5-18-16(8-17)11-25-30-18/h2-11,13,28,31H,12H2,1H3,(H,25,30)(H,26,32)(H,24,27,29)
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PC sid
UniChem
US Patent
n/an/a 28n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402406
PNG
(US10329282, Compound TDI01435)
Show SMILES FC(F)C1CN(C1)C(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C26H21F2N7O/c27-24(28)19-13-35(14-19)26(36)22-9-16-1-2-17(10-21(16)33-22)25-29-8-7-23(34-25)32-20-5-3-15(4-6-20)18-11-30-31-12-18/h1-12,19,24,33H,13-14H2,(H,30,31)(H,29,32,34)
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PC sid
UniChem
US Patent
n/an/a 28n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402338
PNG
(US10329282, Compound TDI01199)
Show SMILES O=C(Nc1cn[nH]c1)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C23H17N9O/c33-23(29-17-11-25-26-12-17)20-8-13-1-2-14(9-19(13)30-20)22-24-6-5-21(31-22)28-16-3-4-18-15(7-16)10-27-32-18/h1-12,30H,(H,25,26)(H,27,32)(H,29,33)(H,24,28,31)
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PC sid
UniChem
US Patent
n/an/a 30n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402357
PNG
(US10329282, Compound TDI01291)
Show SMILES O=C(NC1CCOCC1)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C25H23N7O2/c33-25(29-18-6-9-34-10-7-18)22-12-15-1-2-16(13-21(15)30-22)24-26-8-5-23(31-24)28-19-3-4-20-17(11-19)14-27-32-20/h1-5,8,11-14,18,30H,6-7,9-10H2,(H,27,32)(H,29,33)(H,26,28,31)
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PC sid
UniChem
US Patent
n/an/a 32n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402310
PNG
(US10329282, Compound TDI01130)
Show SMILES COC(=O)c1ccc(NC(=O)c2cc3ccc(cc3[nH]2)-c2nccc(Nc3ccc4[nH]ncc4c3)n2)cc1
Show InChI InChI=1S/C28H21N7O3/c1-38-28(37)16-4-6-20(7-5-16)32-27(36)24-13-17-2-3-18(14-23(17)33-24)26-29-11-10-25(34-26)31-21-8-9-22-19(12-21)15-30-35-22/h2-15,33H,1H3,(H,30,35)(H,32,36)(H,29,31,34)
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PC sid
UniChem
US Patent
n/an/a 33n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402405
PNG
(US10329282, Compound TDI01434)
Show SMILES FC1(F)CN(C1)C(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C25H19F2N7O/c26-25(27)13-34(14-25)24(35)21-9-16-1-2-17(10-20(16)32-21)23-28-8-7-22(33-23)31-19-5-3-15(4-6-19)18-11-29-30-12-18/h1-12,32H,13-14H2,(H,29,30)(H,28,31,33)
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PC sid
UniChem
US Patent
n/an/a 34n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM399177
PNG
(US10323023, Compound TDI01180)
Show SMILES Clc1nnccc1NC(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C24H16ClN9O/c25-22-18(5-8-27-34-22)31-24(35)20-10-13-1-2-14(11-19(13)30-20)23-26-7-6-21(32-23)29-16-3-4-17-15(9-16)12-28-33-17/h1-12,30H,(H,28,33)(H,26,29,32)(H,27,31,35)
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PC cid
PC sid
UniChem
US Patent
n/an/a 37n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402303
PNG
(US10329282, Compound TDI01113)
Show SMILES O=C(NC1CCOC1)c1cc2ccc(cc2s1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1/C24H20N6O2S/c31-24(28-18-6-8-32-13-18)21-10-14-1-2-15(11-20(14)33-21)23-25-7-5-22(29-23)27-17-3-4-19-16(9-17)12-26-30-19/h1-5,7,9-12,18H,6,8,13H2,(H,26,30)(H,28,31)(H,25,27,29)
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PC sid
UniChem
US Patent
n/an/a 42n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402320
PNG
(US10329282, Compound TDI01151)
Show SMILES O=C(NC1CC1)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C23H19N7O/c31-23(27-16-3-4-16)20-10-13-1-2-14(11-19(13)28-20)22-24-8-7-21(29-22)26-17-5-6-18-15(9-17)12-25-30-18/h1-2,5-12,16,28H,3-4H2,(H,25,30)(H,27,31)(H,24,26,29)
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PC sid
UniChem
US Patent
n/an/a 45n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402356
PNG
(US10329282, Compound TDI01290)
Show SMILES Clc1cnccc1NC(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C25H17ClN8O/c26-18-13-27-7-5-20(18)32-25(35)22-10-14-1-2-15(11-21(14)31-22)24-28-8-6-23(33-24)30-17-3-4-19-16(9-17)12-29-34-19/h1-13,31H,(H,29,34)(H,27,32,35)(H,28,30,33)
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PC sid
UniChem
US Patent
n/an/a 46n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402335
PNG
(US10329282, Compound TDI01182)
Show SMILES O=C(Nc1ccc2[nH]ncc2c1)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C27H19N9O/c37-27(32-20-4-6-22-18(10-20)14-30-36-22)24-11-15-1-2-16(12-23(15)33-24)26-28-8-7-25(34-26)31-19-3-5-21-17(9-19)13-29-35-21/h1-14,33H,(H,29,35)(H,30,36)(H,32,37)(H,28,31,34)
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PC cid
PC sid
UniChem
US Patent
n/an/a 46n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM399181
PNG
(US10323023, Compound TDI01201)
Show SMILES Cn1c(cc2ccc(cc12)-c1nccc(Nc2ccc3[nH]ncc3c2)n1)C(=O)Nc1ccnnc1
Show InChI InChI=1S/C25H19N9O/c1-34-21-12-16(3-2-15(21)11-22(34)25(35)31-19-6-9-27-28-14-19)24-26-8-7-23(32-24)30-18-4-5-20-17(10-18)13-29-33-20/h2-14H,1H3,(H,29,33)(H,26,30,32)(H,27,31,35)
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PC cid
PC sid
UniChem
US Patent
n/an/a 48n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402382
PNG
(US10329282, Compound TDI01355)
Show SMILES CN(CC(F)(F)F)C(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C25H20F3N7O/c1-35(14-25(26,27)28)24(36)21-10-16-2-3-17(11-20(16)33-21)23-29-9-8-22(34-23)32-19-6-4-15(5-7-19)18-12-30-31-13-18/h2-13,33H,14H2,1H3,(H,30,31)(H,29,32,34)
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n/an/a 54n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402324
PNG
(US10329282, Compound TDI01160)
Show SMILES O=C(Nc1cnccn1)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C24H17N9O/c34-24(32-22-13-25-7-8-26-22)20-10-14-1-2-15(11-19(14)30-20)23-27-6-5-21(31-23)29-17-3-4-18-16(9-17)12-28-33-18/h1-13,30H,(H,28,33)(H,26,32,34)(H,27,29,31)
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n/an/a 54n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402312
PNG
(US10329282, Compound TDI01134)
Show SMILES Cn1cc(NC(=O)c2cc3ccc(cc3[nH]2)-c2nccc(Nc3ccc4[nH]ncc4c3)n2)cn1
Show InChI InChI=1S/C24H19N9O/c1-33-13-18(12-27-33)29-24(34)21-9-14-2-3-15(10-20(14)30-21)23-25-7-6-22(31-23)28-17-4-5-19-16(8-17)11-26-32-19/h2-13,30H,1H3,(H,26,32)(H,29,34)(H,25,28,31)
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n/an/a 62n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402351
PNG
(US10329282, Compound TDI01258)
Show SMILES O=C(Nc1cnc2[nH]ccc2c1)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C27H19N9O/c37-27(33-20-9-17-5-7-28-25(17)30-14-20)23-11-15-1-2-16(12-22(15)34-23)26-29-8-6-24(35-26)32-19-3-4-21-18(10-19)13-31-36-21/h1-14,34H,(H,28,30)(H,31,36)(H,33,37)(H,29,32,35)
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n/an/a 62n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402328
PNG
(US10329282, Compound TDI01171)
Show SMILES O=C(Nc1cccnc1)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C25H18N8O/c34-25(30-19-2-1-8-26-14-19)22-11-15-3-4-16(12-21(15)31-22)24-27-9-7-23(32-24)29-18-5-6-20-17(10-18)13-28-33-20/h1-14,31H,(H,28,33)(H,30,34)(H,27,29,32)
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n/an/a 63n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402314
PNG
(US10329282, Compound TDI01136)
Show SMILES CC(C)NC(=O)c1cc2ccc(cc2s1)-c1nc(Nc2ccc3[nH]ncc3c2)c2sccc2n1
Show InChI InChI=1S/C25H20N6OS2/c1-13(2)27-25(32)21-10-14-3-4-15(11-20(14)34-21)23-29-19-7-8-33-22(19)24(30-23)28-17-5-6-18-16(9-17)12-26-31-18/h3-13H,1-2H3,(H,26,31)(H,27,32)(H,28,29,30)
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n/an/a 66n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402296
PNG
(US10329282, Compound TDI01104)
Show SMILES CC(C)NC(=O)c1cc2ccc(cc2s1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C23H20N6OS/c1-13(2)26-23(30)20-10-14-3-4-15(11-19(14)31-20)22-24-8-7-21(28-22)27-17-5-6-18-16(9-17)12-25-29-18/h3-13H,1-2H3,(H,25,29)(H,26,30)(H,24,27,28)
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n/an/a 71n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402331
PNG
(US10329282, Compound TDI01177)
Show SMILES O=C(Nc1ccc(cc1)-c1cn[nH]c1)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C29H21N9O/c39-29(35-22-5-3-17(4-6-22)21-15-31-32-16-21)26-12-18-1-2-19(13-25(18)36-26)28-30-10-9-27(37-28)34-23-7-8-24-20(11-23)14-33-38-24/h1-16,36H,(H,31,32)(H,33,38)(H,35,39)(H,30,34,37)
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n/an/a 71n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402318
PNG
(US10329282, Compound TDI01143)
Show SMILES CC(C)NC(=O)c1cc2ccc(cc2[nH]1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cc[nH]c2n1
Show InChI InChI=1S/C25H22N8O/c1-13(2)28-25(34)21-10-14-3-4-15(11-20(14)30-21)22-31-23-18(7-8-26-23)24(32-22)29-17-5-6-19-16(9-17)12-27-33-19/h3-13,30H,1-2H3,(H,27,33)(H,28,34)(H2,26,29,31,32)
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n/an/a 72n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402355
PNG
(US10329282, Compound TDI01289)
Show SMILES CN(C)c1cnccc1NC(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C27H23N9O/c1-36(2)24-15-28-9-7-21(24)33-27(37)23-12-16-3-4-17(13-22(16)32-23)26-29-10-8-25(34-26)31-19-5-6-20-18(11-19)14-30-35-20/h3-15,32H,1-2H3,(H,30,35)(H,28,33,37)(H,29,31,34)
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n/an/a 72n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402363
PNG
(US10329282, Compound TDI01312)
Show SMILES CC(C)NC(=O)N1Cc2ccc(cc2C1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C23H23N7O/c1-14(2)26-23(31)30-12-16-4-3-15(9-18(16)13-30)22-24-8-7-21(28-22)27-19-5-6-20-17(10-19)11-25-29-20/h3-11,14H,12-13H2,1-2H3,(H,25,29)(H,26,31)(H,24,27,28)
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n/an/a 73n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402316
PNG
(US10329282, Compound TDI01141)
Show SMILES CC(C)NC(=O)c1cc2ccc(cc2[nH]1)-c1nc(Nc2ccc3[nH]ncc3c2)c2sccc2n1
Show InChI InChI=1S/C25H21N7OS/c1-13(2)27-25(33)21-10-14-3-4-15(11-20(14)29-21)23-30-19-7-8-34-22(19)24(31-23)28-17-5-6-18-16(9-17)12-26-32-18/h3-13,29H,1-2H3,(H,26,32)(H,27,33)(H,28,30,31)
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n/an/a 73n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402409
PNG
(US10329282, Compound TDI01829B)
Show SMILES O=C(Nc1ccncc1C#N)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C28H19N9O/c29-13-20-14-30-9-7-23(20)36-28(38)25-11-18-1-2-19(12-24(18)35-25)27-31-10-8-26(37-27)34-22-5-3-17(4-6-22)21-15-32-33-16-21/h1-12,14-16,35H,(H,32,33)(H,30,36,38)(H,31,34,37)
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n/an/a 82n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402365
PNG
(US10329282, Compound TDI01316)
Show SMILES CN1CCC(CC1)n1cc(NC(=O)c2cc3ccc(cc3[nH]2)-c2nccc(Nc3ccc4[nH]ncc4c3)n2)cn1
Show InChI InChI=1S/C29H28N10O/c1-38-10-7-23(8-11-38)39-17-22(16-32-39)34-29(40)26-13-18-2-3-19(14-25(18)35-26)28-30-9-6-27(36-28)33-21-4-5-24-20(12-21)15-31-37-24/h2-6,9,12-17,23,35H,7-8,10-11H2,1H3,(H,31,37)(H,34,40)(H,30,33,36)
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n/an/a 87n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM399127
PNG
(US10323023, Compound TDI01152)
Show SMILES O=C(Nc1ccnnc1)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C24H17N9O/c34-24(30-18-5-8-26-27-13-18)21-10-14-1-2-15(11-20(14)31-21)23-25-7-6-22(32-23)29-17-3-4-19-16(9-17)12-28-33-19/h1-13,31H,(H,28,33)(H,25,29,32)(H,26,30,34)
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n/an/a 88n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402343
PNG
(US10329282, Compound TDI01221)
Show SMILES CN(C)c1ccc(NC(=O)c2cc3ccc(cc3[nH]2)-c2nccc(Nc3ccc4[nH]ncc4c3)n2)cn1
Show InChI InChI=1S/C27H23N9O/c1-36(2)25-8-6-20(15-29-25)32-27(37)23-12-16-3-4-17(13-22(16)33-23)26-28-10-9-24(34-26)31-19-5-7-21-18(11-19)14-30-35-21/h3-15,33H,1-2H3,(H,30,35)(H,32,37)(H,28,31,34)
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BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM399178
PNG
(US10323023, Compound TDI01181)
Show SMILES Clc1cnncc1NC(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C24H16ClN9O/c25-17-11-27-28-12-21(17)32-24(35)20-8-13-1-2-14(9-19(13)31-20)23-26-6-5-22(33-23)30-16-3-4-18-15(7-16)10-29-34-18/h1-12,31H,(H,29,34)(H,26,30,33)(H,27,32,35)
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BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402353
PNG
(US10329282, Compound TDI01280)
Show SMILES CC(C)NC(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C25H23N7O/c1-15(2)29-25(33)22-11-17-3-4-18(12-21(17)31-22)24-26-10-9-23(32-24)30-20-7-5-16(6-8-20)19-13-27-28-14-19/h3-15,31H,1-2H3,(H,27,28)(H,29,33)(H,26,30,32)
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n/an/a 94n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402378
PNG
(US10329282, Compound TDI01344)
Show SMILES CN(C1COC1)C(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C26H23N7O2/c1-33(21-14-35-15-21)26(34)23-10-17-2-3-18(11-22(17)31-23)25-27-9-8-24(32-25)30-20-6-4-16(5-7-20)19-12-28-29-13-19/h2-13,21,31H,14-15H2,1H3,(H,28,29)(H,27,30,32)
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BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402410
PNG
(US10329282, Compound TDI01829C)
Show SMILES Ic1cnccc1NC(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C27H19IN8O/c28-21-15-29-9-7-22(21)35-27(37)24-11-17-1-2-18(12-23(17)34-24)26-30-10-8-25(36-26)33-20-5-3-16(4-6-20)19-13-31-32-14-19/h1-15,34H,(H,31,32)(H,29,35,37)(H,30,33,36)
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BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402301
PNG
(US10329282, Compound TDI01111)
Show SMILES O=C(NC1CC1)c1cc2ccc(cc2s1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C23H18N6OS/c30-23(27-16-3-4-16)20-10-13-1-2-14(11-19(13)31-20)22-24-8-7-21(28-22)26-17-5-6-18-15(9-17)12-25-29-18/h1-2,5-12,16H,3-4H2,(H,25,29)(H,27,30)(H,24,26,28)
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n/an/a 100n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402308
PNG
(US10329282, Compound TDI01127)
Show SMILES CC(C)NC(=O)c1ccc2cc([nH]c2c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C23H21N7O/c1-13(2)26-23(31)15-4-3-14-10-20(28-19(14)11-15)22-24-8-7-21(29-22)27-17-5-6-18-16(9-17)12-25-30-18/h3-13,28H,1-2H3,(H,25,30)(H,26,31)(H,24,27,29)
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n/an/a 100n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402319
PNG
(US10329282, Compound TDI01149)
Show SMILES CC(C)NC(=O)c1cc2ccc(cc2[nH]1)-c1nc(Nc2ccc3[nH]ncc3c2)c2scnc2n1
Show InChI InChI=1S/C24H20N8OS/c1-12(2)27-24(33)19-8-13-3-4-14(9-18(13)29-19)21-30-22-20(34-11-25-22)23(31-21)28-16-5-6-17-15(7-16)10-26-32-17/h3-12,29H,1-2H3,(H,26,32)(H,27,33)(H,28,30,31)
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n/an/a 100n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402369
PNG
(US10329282, Compound TDI01324)
Show SMILES O=C(NC1CC1)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C25H21N7O/c33-25(30-20-7-8-20)22-11-16-1-2-17(12-21(16)31-22)24-26-10-9-23(32-24)29-19-5-3-15(4-6-19)18-13-27-28-14-18/h1-6,9-14,20,31H,7-8H2,(H,27,28)(H,30,33)(H,26,29,32)
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n/an/a 101n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM399187
PNG
(US10323023, Compound TDI01251)
Show SMILES Cc1cc(Nc2ccc3[nH]ncc3c2)nc(n1)-c1ccc2cc([nH]c2c1)C(=O)Nc1ccnnc1
Show InChI InChI=1S/C25H19N9O/c1-14-8-23(30-18-4-5-20-17(9-18)12-28-34-20)33-24(29-14)16-3-2-15-10-22(32-21(15)11-16)25(35)31-19-6-7-26-27-13-19/h2-13,32H,1H3,(H,28,34)(H,26,31,35)(H,29,30,33)
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n/an/a 101n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402311
PNG
(US10329282, Compound TDI01131)
Show SMILES CN1CCN(CC1)c1ccc(NC(=O)c2cc3ccc(cc3[nH]2)-c2nccc(Nc3ccc4[nH]ncc4c3)n2)cc1
Show InChI InChI=1S/C31H29N9O/c1-39-12-14-40(15-13-39)25-7-4-23(5-8-25)35-31(41)28-17-20-2-3-21(18-27(20)36-28)30-32-11-10-29(37-30)34-24-6-9-26-22(16-24)19-33-38-26/h2-11,16-19,36H,12-15H2,1H3,(H,33,38)(H,35,41)(H,32,34,37)
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n/an/a 101n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402383
PNG
(US10329282, Compound TDI01363)
Show SMILES O=C(Nc1ccncc1)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C27H20N8O/c36-27(33-22-7-10-28-11-8-22)24-13-18-1-2-19(14-23(18)34-24)26-29-12-9-25(35-26)32-21-5-3-17(4-6-21)20-15-30-31-16-20/h1-16,34H,(H,30,31)(H,28,33,36)(H,29,32,35)
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n/an/a 104n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402392
PNG
(US10329282, Compound TDI01344-2A)
Show SMILES CN(C(CO)CO)C(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C26H25N7O3/c1-33(21(14-34)15-35)26(36)23-10-17-2-3-18(11-22(17)31-23)25-27-9-8-24(32-25)30-20-6-4-16(5-7-20)19-12-28-29-13-19/h2-13,21,31,34-35H,14-15H2,1H3,(H,28,29)(H,27,30,32)
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n/an/a 107n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402344
PNG
(US10329282, Compound TDI01230)
Show SMILES CN1CCN(CC(=O)n2ccc3ccc(cc23)-c2nccc(Nc3ccc4[nH]ncc4c3)n2)CC1
Show InChI InChI=1S/C26H26N8O/c1-32-10-12-33(13-11-32)17-25(35)34-9-7-18-2-3-19(15-23(18)34)26-27-8-6-24(30-26)29-21-4-5-22-20(14-21)16-28-31-22/h2-9,14-16H,10-13,17H2,1H3,(H,28,31)(H,27,29,30)
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n/an/a 109n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402315
PNG
(US10329282, Compound TDI01140)
Show SMILES CC(NC(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1)c1ccccc1
Show InChI InChI=1/C28H23N7O/c1-17(18-5-3-2-4-6-18)31-28(36)25-14-19-7-8-20(15-24(19)33-25)27-29-12-11-26(34-27)32-22-9-10-23-21(13-22)16-30-35-23/h2-17,33H,1H3,(H,30,35)(H,31,36)(H,29,32,34)
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n/an/a 109n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402386
PNG
(US10329282, Compound TDI01370)
Show SMILES CC(C)NC(=O)c1cc2ccc(cc2[nH]1)-c1nc(Nc2ccc(cc2)-c2cn[nH]c2)c2sccc2n1
Show InChI InChI=1S/C27H23N7OS/c1-15(2)30-27(35)23-11-17-3-4-18(12-22(17)32-23)25-33-21-9-10-36-24(21)26(34-25)31-20-7-5-16(6-8-20)19-13-28-29-14-19/h3-15,32H,1-2H3,(H,28,29)(H,30,35)(H,31,33,34)
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n/an/a 109n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402294
PNG
(US10329282, Compound TDI01102)
Show SMILES CC(C)NC(=O)c1cc2ccc(cc2o1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C23H20N6O2/c1-13(2)26-23(30)20-10-14-3-4-15(11-19(14)31-20)22-24-8-7-21(28-22)27-17-5-6-18-16(9-17)12-25-29-18/h3-13H,1-2H3,(H,25,29)(H,26,30)(H,24,27,28)
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n/an/a 110n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402297
PNG
(US10329282, Compound TDI01106)
Show SMILES CC(C)NC(=O)c1ccc2cc(sc2c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C23H20N6OS/c1-13(2)26-23(30)15-4-3-14-10-20(31-19(14)11-15)22-24-8-7-21(28-22)27-17-5-6-18-16(9-17)12-25-29-18/h3-13H,1-2H3,(H,25,29)(H,26,30)(H,24,27,28)
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n/an/a 112n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402366
PNG
(US10329282, Compound TDI01317)
Show SMILES CN1CCC(CC1)N1CCC(CC1)NC(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C31H35N9O/c1-39-12-9-25(10-13-39)40-14-7-23(8-15-40)35-31(41)28-17-20-2-3-21(18-27(20)36-28)30-32-11-6-29(37-30)34-24-4-5-26-22(16-24)19-33-38-26/h2-6,11,16-19,23,25,36H,7-10,12-15H2,1H3,(H,33,38)(H,35,41)(H,32,34,37)
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n/an/a 112n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM399188
PNG
(US10323023, Compound TDI01276)
Show SMILES Cc1c(Nc2ccnc(n2)-c2ccc3cc([nH]c3c2)C(=O)Nc2ccnnc2)ccc2[nH]ncc12
Show InChI InChI=1S/C25H19N9O/c1-14-18-13-29-34-20(18)5-4-19(14)32-23-7-8-26-24(33-23)16-3-2-15-10-22(31-21(15)11-16)25(35)30-17-6-9-27-28-12-17/h2-13,31H,1H3,(H,29,34)(H,26,32,33)(H,27,30,35)
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n/an/a 113n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402375
PNG
(US10329282, Compound TDI01338)
Show SMILES O=C(NC1CCOCC1)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C27H25N7O2/c35-27(32-22-8-11-36-12-9-22)24-13-18-1-2-19(14-23(18)33-24)26-28-10-7-25(34-26)31-21-5-3-17(4-6-21)20-15-29-30-16-20/h1-7,10,13-16,22,33H,8-9,11-12H2,(H,29,30)(H,32,35)(H,28,31,34)
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n/an/a 115n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402403
PNG
(US10329282, Compound TDI01430)
Show SMILES CN(CC#N)C(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C25H20N8O/c1-33(11-9-26)25(34)22-12-17-2-3-18(13-21(17)31-22)24-27-10-8-23(32-24)30-20-6-4-16(5-7-20)19-14-28-29-15-19/h2-8,10,12-15,31H,11H2,1H3,(H,28,29)(H,27,30,32)
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n/an/a 116n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402354
PNG
(US10329282, Compound TDI01285)
Show SMILES CC(C)NC(=O)c1c[nH]c2ccc(cc12)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C23H21N7O/c1-13(2)27-23(31)18-12-25-20-5-3-14(10-17(18)20)22-24-8-7-21(29-22)28-16-4-6-19-15(9-16)11-26-30-19/h3-13,25H,1-2H3,(H,26,30)(H,27,31)(H,24,28,29)
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n/an/a 116n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402401
PNG
(US10329282, Compound TDI01425)
Show SMILES O=C(N1CCC2(CCNCC2)CC1)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C31H32N8O/c40-30(39-15-10-31(11-16-39)8-13-32-14-9-31)27-17-22-1-2-23(18-26(22)37-27)29-33-12-7-28(38-29)36-25-5-3-21(4-6-25)24-19-34-35-20-24/h1-7,12,17-20,32,37H,8-11,13-16H2,(H,34,35)(H,33,36,38)
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n/an/a 119n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402390
PNG
(US10329282, Compound TDI01397)
Show SMILES O=C(Nc1cccnc1)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C27H20N8O/c36-27(33-22-2-1-10-28-16-22)24-12-18-3-4-19(13-23(18)34-24)26-29-11-9-25(35-26)32-21-7-5-17(6-8-21)20-14-30-31-15-20/h1-16,34H,(H,30,31)(H,33,36)(H,29,32,35)
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BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402374
PNG
(US10329282, Compound TDI01337)
Show SMILES O=C(NC1CCOC1)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1/C26H23N7O2/c34-26(31-21-8-10-35-15-21)23-11-17-1-2-18(12-22(17)32-23)25-27-9-7-24(33-25)30-20-5-3-16(4-6-20)19-13-28-29-14-19/h1-7,9,11-14,21,32H,8,10,15H2,(H,28,29)(H,31,34)(H,27,30,33)
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n/an/a 121n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402313
PNG
(US10329282, Compound TDI01135)
Show SMILES CC(C)NC(=O)c1cc2ccc(cc2s1)-c1nc(Nc2ccc3[nH]ncc3c2)c2occc2n1
Show InChI InChI=1S/C25H20N6O2S/c1-13(2)27-25(32)21-10-14-3-4-15(11-20(14)34-21)23-29-19-7-8-33-22(19)24(30-23)28-17-5-6-18-16(9-17)12-26-31-18/h3-13H,1-2H3,(H,26,31)(H,27,32)(H,28,29,30)
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n/an/a 123n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM399179
PNG
(US10323023, Compound TDI01188)
Show SMILES O=C(Nc1ccnnc1)c1cc2cc(ccc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C24H17N9O/c34-24(30-18-5-8-26-27-13-18)21-11-15-9-14(1-3-19(15)31-21)23-25-7-6-22(32-23)29-17-2-4-20-16(10-17)12-28-33-20/h1-13,31H,(H,28,33)(H,25,29,32)(H,26,30,34)
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n/an/a 123n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402364
PNG
(US10329282, Compound TDI01315)
Show SMILES COc1ccc(NC(=O)c2cc3ccc(cc3[nH]2)-c2nccc(Nc3ccc4[nH]ncc4c3)n2)cn1
Show InChI InChI=1S/C26H20N8O2/c1-36-24-7-5-19(14-28-24)31-26(35)22-11-15-2-3-16(12-21(15)32-22)25-27-9-8-23(33-25)30-18-4-6-20-17(10-18)13-29-34-20/h2-14,32H,1H3,(H,29,34)(H,31,35)(H,27,30,33)
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n/an/a 126n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402348
PNG
(US10329282, Compound TDI01247)
Show SMILES O=C(Nc1nncs1)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C22H15N9OS/c32-21(29-22-31-25-11-33-22)18-8-12-1-2-13(9-17(12)27-18)20-23-6-5-19(28-20)26-15-3-4-16-14(7-15)10-24-30-16/h1-11,27H,(H,24,30)(H,23,26,28)(H,29,31,32)
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n/an/a 134n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM399184
PNG
(US10323023, Compound TDI01236)
Show SMILES O=C(Nc1ccnnc1)c1ccc2ccc(cc2n1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C25H17N9O/c35-25(31-19-7-10-27-28-14-19)21-5-3-15-1-2-16(12-22(15)32-21)24-26-9-8-23(33-24)30-18-4-6-20-17(11-18)13-29-34-20/h1-14H,(H,29,34)(H,26,30,33)(H,27,31,35)
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n/an/a 135n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402400
PNG
(US10329282, Compound TDI01424)
Show SMILES O=C(NC1CCC1)c1cc2ccc(cc2[nH]1)-c1nc(Nc2ccc(cc2)-c2cn[nH]c2)c2sccc2n1
Show InChI InChI=1S/C28H23N7OS/c36-28(32-20-2-1-3-20)24-12-17-4-5-18(13-23(17)33-24)26-34-22-10-11-37-25(22)27(35-26)31-21-8-6-16(7-9-21)19-14-29-30-15-19/h4-15,20,33H,1-3H2,(H,29,30)(H,32,36)(H,31,34,35)
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n/an/a 138n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402416
PNG
(US10329282, Compound TDI01856)
Show SMILES C[C@@H](CN)NC(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1/C25H24N8O/c1-15(12-26)30-25(34)22-10-17-2-3-18(11-21(17)32-22)24-27-9-8-23(33-24)31-20-6-4-16(5-7-20)19-13-28-29-14-19/h2-11,13-15,32H,12,26H2,1H3,(H,28,29)(H,30,34)(H,27,31,33)/t15-/s2
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n/an/a 141n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402309
PNG
(US10329282, Compound TDI01128)
Show SMILES CC(C)NC(=O)c1cc2ccc(cc2[nH]1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1
Show InChI InChI=1S/C27H23N7O/c1-15(2)29-27(35)24-12-16-7-8-17(13-23(16)31-24)25-32-22-6-4-3-5-20(22)26(33-25)30-19-9-10-21-18(11-19)14-28-34-21/h3-15,31H,1-2H3,(H,28,34)(H,29,35)(H,30,32,33)
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n/an/a 145n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402415
PNG
(US10329282, Compound TDI01855)
Show SMILES C[C@H](CN)NC(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1/C25H24N8O/c1-15(12-26)30-25(34)22-10-17-2-3-18(11-21(17)32-22)24-27-9-8-23(33-24)31-20-6-4-16(5-7-20)19-13-28-29-14-19/h2-11,13-15,32H,12,26H2,1H3,(H,28,29)(H,30,34)(H,27,31,33)/t15-/s2
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n/an/a 147n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402376
PNG
(US10329282, Compound TDI01339)
Show SMILES CN1CCC(C1)NC(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1/C27H26N8O/c1-35-11-9-22(16-35)32-27(36)24-12-18-2-3-19(13-23(18)33-24)26-28-10-8-25(34-26)31-21-6-4-17(5-7-21)20-14-29-30-15-20/h2-8,10,12-15,22,33H,9,11,16H2,1H3,(H,29,30)(H,32,36)(H,28,31,34)
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n/an/a 147n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402304
PNG
(US10329282, Compound TDI01114)
Show SMILES CN1CCC(CC1)NC(=O)c1cc2ccc(cc2s1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C26H25N7OS/c1-33-10-7-19(8-11-33)30-26(34)23-13-16-2-3-17(14-22(16)35-23)25-27-9-6-24(31-25)29-20-4-5-21-18(12-20)15-28-32-21/h2-6,9,12-15,19H,7-8,10-11H2,1H3,(H,28,32)(H,30,34)(H,27,29,31)
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n/an/a 157n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402295
PNG
(US10329282, Compound TDI01103)
Show SMILES CC(C)NC(=O)C1COc2ccc(cc2O1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1/C23H22N6O3/c1-13(2)26-23(30)20-12-31-18-6-3-14(10-19(18)32-20)22-24-8-7-21(28-22)27-16-4-5-17-15(9-16)11-25-29-17/h3-11,13,20H,12H2,1-2H3,(H,25,29)(H,26,30)(H,24,27,28)
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n/an/a 167n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM399176
PNG
(US10323023, Compound TDI01178)
Show SMILES O=C(NCc1ccnnc1)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C25H19N9O/c35-25(27-12-15-5-8-28-29-13-15)22-10-16-1-2-17(11-21(16)32-22)24-26-7-6-23(33-24)31-19-3-4-20-18(9-19)14-30-34-20/h1-11,13-14,32H,12H2,(H,27,35)(H,30,34)(H,26,31,33)
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n/an/a 168n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM399185
PNG
(US10323023, Compound TDI01237)
Show SMILES O=C(Nc1ccnnc1)N1Cc2ccc(cc2C1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C24H19N9O/c34-24(30-20-5-8-26-27-12-20)33-13-16-2-1-15(9-18(16)14-33)23-25-7-6-22(31-23)29-19-3-4-21-17(10-19)11-28-32-21/h1-12H,13-14H2,(H,28,32)(H,25,29,31)(H,26,30,34)
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n/an/a 171n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402302
PNG
(US10329282, Compound TDI01112)
Show SMILES O=C(NC1CCCCC1)c1cc2ccc(cc2s1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C26H24N6OS/c33-26(30-19-4-2-1-3-5-19)23-13-16-6-7-17(14-22(16)34-23)25-27-11-10-24(31-25)29-20-8-9-21-18(12-20)15-28-32-21/h6-15,19H,1-5H2,(H,28,32)(H,30,33)(H,27,29,31)
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n/an/a 185n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402329
PNG
(US10329282, Compound TDI01175)
Show SMILES O=C(Nc1ccnnc1)c1cc2ccc(cc2[nH]1)-c1nc(Nc2ccc3[nH]ncc3c2)c2sccc2n1
Show InChI InChI=1S/C26H17N9OS/c36-26(31-18-5-7-27-28-13-18)22-10-14-1-2-15(11-21(14)32-22)24-33-20-6-8-37-23(20)25(34-24)30-17-3-4-19-16(9-17)12-29-35-19/h1-13,32H,(H,29,35)(H,27,31,36)(H,30,33,34)
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n/an/a 197n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM399186
PNG
(US10323023, Compound TDI01250)
Show SMILES Cc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1ccc2cc([nH]c2c1)C(=O)Nc1ccnnc1
Show InChI InChI=1S/C25H19N9O/c1-14-11-26-24(33-23(14)30-18-4-5-20-17(8-18)12-29-34-20)16-3-2-15-9-22(32-21(15)10-16)25(35)31-19-6-7-27-28-13-19/h2-13,32H,1H3,(H,29,34)(H,26,30,33)(H,27,31,35)
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n/an/a 208n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402325
PNG
(US10329282, Compound TDI01161)
Show SMILES O=C(Nc1ccncn1)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C24H17N9O/c34-24(32-21-5-7-25-13-27-21)20-10-14-1-2-15(11-19(14)30-20)23-26-8-6-22(31-23)29-17-3-4-18-16(9-17)12-28-33-18/h1-13,30H,(H,28,33)(H,26,29,31)(H,25,27,32,34)
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n/an/a 210n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402412
PNG
(US10329282, Compound TDI01849B)
Show SMILES C[C@@H](NC(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1)c1ccncc1
Show InChI InChI=1/C29H24N8O/c1-18(19-8-11-30-12-9-19)34-29(38)26-14-21-2-3-22(15-25(21)36-26)28-31-13-10-27(37-28)35-24-6-4-20(5-7-24)23-16-32-33-17-23/h2-18,36H,1H3,(H,32,33)(H,34,38)(H,31,35,37)/t18-/s2
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n/an/a 210n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402360
PNG
(US10329282, Compound TDI01296)
Show SMILES CNC(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C23H19N7O/c1-24-23(31)20-10-15-2-3-16(11-19(15)29-20)22-25-9-8-21(30-22)28-18-6-4-14(5-7-18)17-12-26-27-13-17/h2-13,29H,1H3,(H,24,31)(H,26,27)(H,25,28,30)
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n/an/a 211n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402307
PNG
(US10329282, Compound TDI01122)
Show SMILES CC(C)NC(=O)c1cc2ccc(cc2s1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccn(CCN(C)C)c2n1
Show InChI InChI=1S/C29H30N8OS/c1-17(2)31-29(38)25-14-18-5-6-19(15-24(18)39-25)26-33-27(32-21-7-8-23-20(13-21)16-30-35-23)22-9-10-37(28(22)34-26)12-11-36(3)4/h5-10,13-17H,11-12H2,1-4H3,(H,30,35)(H,31,38)(H,32,33,34)
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n/an/a 219n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM399174
PNG
(US10323023, Compound TDI01167)
Show SMILES O=C(Nc1ccnnc1)c1cc2ccc(cc2[nH]1)-c1ncnc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C23H16N10O/c34-22(29-17-5-6-26-27-11-17)20-8-13-1-2-14(9-19(13)31-20)21-24-12-25-23(32-21)30-16-3-4-18-15(7-16)10-28-33-18/h1-12,31H,(H,28,33)(H,26,29,34)(H,24,25,30,32)
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n/an/a 223n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM399180
PNG
(US10323023, Compound TDI01191)
Show SMILES O=C(Nc1ccnnc1)c1c[nH]c2ccc(cc12)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C24H17N9O/c34-24(31-17-5-8-27-28-12-17)19-13-26-21-3-1-14(10-18(19)21)23-25-7-6-22(32-23)30-16-2-4-20-15(9-16)11-29-33-20/h1-13,26H,(H,29,33)(H,25,30,32)(H,27,31,34)
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n/an/a 225n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402317
PNG
(US10329282, Compound TDI01142)
Show SMILES CC(C)NC(=O)c1cc2ccc(cc2[nH]1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccsc2n1
Show InChI InChI=1S/C25H21N7OS/c1-13(2)27-24(33)21-10-14-3-4-15(11-20(14)29-21)22-30-23(18-7-8-34-25(18)31-22)28-17-5-6-19-16(9-17)12-26-32-19/h3-13,29H,1-2H3,(H,26,32)(H,27,33)(H,28,30,31)
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n/an/a 225n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM398658
PNG
(US10323023, Compound TDI01116)
Show SMILES O=C(Nc1ccnnc1)c1cc2ccc(cc2s1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C24H16N8OS/c33-24(30-18-5-8-26-27-13-18)21-10-14-1-2-15(11-20(14)34-21)23-25-7-6-22(31-23)29-17-3-4-19-16(9-17)12-28-32-19/h1-13H,(H,28,32)(H,25,29,31)(H,26,30,33)
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n/an/a 236n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402358
PNG
(US10329282, Compound TDI01292)
Show SMILES CC(C)NC(=O)C1Cc2ccc(cc2N1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1/C23H23N7O/c1-13(2)26-23(31)20-10-14-3-4-15(11-19(14)28-20)22-24-8-7-21(29-22)27-17-5-6-18-16(9-17)12-25-30-18/h3-9,11-13,20,28H,10H2,1-2H3,(H,25,30)(H,26,31)(H,24,27,29)
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n/an/a 242n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402381
PNG
(US10329282, Compound TDI01354)
Show SMILES Clc1cnccc1NC(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C27H19ClN8O/c28-21-15-29-9-7-22(21)35-27(37)24-11-17-1-2-18(12-23(17)34-24)26-30-10-8-25(36-26)33-20-5-3-16(4-6-20)19-13-31-32-14-19/h1-15,34H,(H,31,32)(H,29,35,37)(H,30,33,36)
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n/an/a 254n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM399182
PNG
(US10323023, Compound TDI01213)
Show SMILES Fc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1ccc2cc([nH]c2c1)C(=O)Nc1ccnnc1
Show InChI InChI=1S/C24H16FN9O/c25-18-12-26-22(33-23(18)30-16-3-4-19-15(7-16)10-29-34-19)14-2-1-13-8-21(32-20(13)9-14)24(35)31-17-5-6-27-28-11-17/h1-12,32H,(H,29,34)(H,26,30,33)(H,27,31,35)
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n/an/a 255n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402373
PNG
(US10329282, Compound TDI01332)
Show SMILES CCN(CC)C(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C26H25N7O/c1-3-33(4-2)26(34)23-13-18-5-6-19(14-22(18)31-23)25-27-12-11-24(32-25)30-21-9-7-17(8-10-21)20-15-28-29-16-20/h5-16,31H,3-4H2,1-2H3,(H,28,29)(H,27,30,32)
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n/an/a 257n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402394
PNG
(US10329282, Compound TDI01411)
Show SMILES CCNC(=O)N1Cc2ccc(cc2C1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C24H23N7O/c1-2-25-24(32)31-14-18-4-3-17(11-19(18)15-31)23-26-10-9-22(30-23)29-21-7-5-16(6-8-21)20-12-27-28-13-20/h3-13H,2,14-15H2,1H3,(H,25,32)(H,27,28)(H,26,29,30)
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n/an/a 258n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402389
PNG
(US10329282, Compound TDI01393)
Show SMILES O=C(Nc1ccncc1)c1cc2ccc(cc2s1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C27H19N7OS/c35-27(33-22-7-10-28-11-8-22)24-13-18-1-2-19(14-23(18)36-24)26-29-12-9-25(34-26)32-21-5-3-17(4-6-21)20-15-30-31-16-20/h1-16H,(H,30,31)(H,28,33,35)(H,29,32,34)
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BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402384
PNG
(US10329282, Compound TDI01366)
Show SMILES CN(C)C(=O)N1Cc2ccc(cc2C1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C24H23N7O/c1-30(2)24(32)31-14-18-4-3-17(11-19(18)15-31)23-25-10-9-22(29-23)28-21-7-5-16(6-8-21)20-12-26-27-13-20/h3-13H,14-15H2,1-2H3,(H,26,27)(H,25,28,29)
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n/an/a 260n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402372
PNG
(US10329282, Compound TDI01331)
Show SMILES O=C(N1CCOCC1)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C26H23N7O2/c34-26(33-9-11-35-12-10-33)23-13-18-1-2-19(14-22(18)31-23)25-27-8-7-24(32-25)30-21-5-3-17(4-6-21)20-15-28-29-16-20/h1-8,13-16,31H,9-12H2,(H,28,29)(H,27,30,32)
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n/an/a 260n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402395
PNG
(US10329282, Compound TDI01415)
Show SMILES CCN(CCO)C(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C26H25N7O2/c1-2-33(11-12-34)26(35)23-13-18-3-4-19(14-22(18)31-23)25-27-10-9-24(32-25)30-21-7-5-17(6-8-21)20-15-28-29-16-20/h3-10,13-16,31,34H,2,11-12H2,1H3,(H,28,29)(H,27,30,32)
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n/an/a 262n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402399
PNG
(US10329282, Compound TDI01423)
Show SMILES O=C(NC1CCOC1)c1cc2ccc(cc2[nH]1)-c1nc(Nc2ccc(cc2)-c2cn[nH]c2)c2sccc2n1
Show InChI InChI=1/C28H23N7O2S/c36-28(32-21-7-9-37-15-21)24-11-17-1-2-18(12-23(17)33-24)26-34-22-8-10-38-25(22)27(35-26)31-20-5-3-16(4-6-20)19-13-29-30-14-19/h1-6,8,10-14,21,33H,7,9,15H2,(H,29,30)(H,32,36)(H,31,34,35)
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n/an/a 264n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402385
PNG
(US10329282, Compound TDI01369)
Show SMILES O=C(N1CC2(CNC2)C1)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C27H24N8O/c36-26(35-15-27(16-35)13-28-14-27)23-9-18-1-2-19(10-22(18)33-23)25-29-8-7-24(34-25)32-21-5-3-17(4-6-21)20-11-30-31-12-20/h1-12,28,33H,13-16H2,(H,30,31)(H,29,32,34)
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n/an/a 266n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402396
PNG
(US10329282, Compound TDI01418)
Show SMILES CN(C1CC(O)C1)C(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C27H25N7O2/c1-34(21-12-22(35)13-21)27(36)24-10-17-2-3-18(11-23(17)32-24)26-28-9-8-25(33-26)31-20-6-4-16(5-7-20)19-14-29-30-15-19/h2-11,14-15,21-22,32,35H,12-13H2,1H3,(H,29,30)(H,28,31,33)
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n/an/a 272n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402414
PNG
(US10329282, Compound TDI01853)
Show SMILES OC[C@@H]1COCCN1C(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1/C27H25N7O3/c35-15-22-16-37-10-9-34(22)27(36)24-11-18-1-2-19(12-23(18)32-24)26-28-8-7-25(33-26)31-21-5-3-17(4-6-21)20-13-29-30-14-20/h1-8,11-14,22,32,35H,9-10,15-16H2,(H,29,30)(H,28,31,33)/t22-/s2
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BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402398
PNG
(US10329282, Compound TDI01421)
Show SMILES CN(C(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1)c1ccncc1
Show InChI InChI=1S/C28H22N8O/c1-36(23-8-11-29-12-9-23)28(37)25-14-19-2-3-20(15-24(19)34-25)27-30-13-10-26(35-27)33-22-6-4-18(5-7-22)21-16-31-32-17-21/h2-17,34H,1H3,(H,31,32)(H,30,33,35)
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n/an/a 289n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM399183
PNG
(US10323023, Compound TDI01232)
Show SMILES Cc1nc(nc(Nc2ccc3[nH]ncc3c2)c1C)-c1ccc2cc([nH]c2c1)C(=O)Nc1ccnnc1
Show InChI InChI=1S/C26H21N9O/c1-14-15(2)30-25(34-24(14)31-19-5-6-21-18(9-19)12-29-35-21)17-4-3-16-10-23(33-22(16)11-17)26(36)32-20-7-8-27-28-13-20/h3-13,33H,1-2H3,(H,29,35)(H,27,32,36)(H,30,31,34)
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BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402407
PNG
(US10329282, Compound TDI01442)
Show SMILES CN(CCC#N)C(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C26H22N8O/c1-34(12-2-10-27)26(35)23-13-18-3-4-19(14-22(18)32-23)25-28-11-9-24(33-25)31-21-7-5-17(6-8-21)20-15-29-30-16-20/h3-9,11,13-16,32H,2,12H2,1H3,(H,29,30)(H,28,31,33)
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n/an/a 305n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402379
PNG
(US10329282, Compound TDI01345)
Show SMILES CN(C1CCNC1)C(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1/C27H26N8O/c1-35(22-8-10-28-16-22)27(36)24-12-18-2-3-19(13-23(18)33-24)26-29-11-9-25(34-26)32-21-6-4-17(5-7-21)20-14-30-31-15-20/h2-7,9,11-15,22,28,33H,8,10,16H2,1H3,(H,30,31)(H,29,32,34)
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n/an/a 333n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402408
PNG
(US10329282, Compound TDI01823)
Show SMILES CCN(CC)C(=O)c1cc2ccc(cc2[nH]1)-c1ncc(OC)c(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C27H27N7O2/c1-4-34(5-2)27(35)23-12-18-6-7-19(13-22(18)32-23)25-28-16-24(36-3)26(33-25)31-21-10-8-17(9-11-21)20-14-29-30-15-20/h6-16,32H,4-5H2,1-3H3,(H,29,30)(H,28,31,33)
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n/an/a 336n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402388
PNG
(US10329282, Compound TDI01381)
Show SMILES CN(C1CCOCC1)C(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C28H27N7O2/c1-35(23-9-12-37-13-10-23)28(36)25-14-19-2-3-20(15-24(19)33-25)27-29-11-8-26(34-27)32-22-6-4-18(5-7-22)21-16-30-31-17-21/h2-8,11,14-17,23,33H,9-10,12-13H2,1H3,(H,30,31)(H,29,32,34)
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n/an/a 341n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402359
PNG
(US10329282, Compound TDI01294)
Show SMILES CN(C)C(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C24H21N7O/c1-31(2)24(32)21-11-16-3-4-17(12-20(16)29-21)23-25-10-9-22(30-23)28-19-7-5-15(6-8-19)18-13-26-27-14-18/h3-14,29H,1-2H3,(H,26,27)(H,25,28,30)
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n/an/a 352n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM399189
PNG
(US10323023, Compound TDI01347)
Show SMILES CN(C(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1)c1ccnnc1
Show InChI InChI=1S/C25H19N9O/c1-34(19-6-9-27-28-14-19)25(35)22-11-15-2-3-16(12-21(15)31-22)24-26-8-7-23(32-24)30-18-4-5-20-17(10-18)13-29-33-20/h2-14,31H,1H3,(H,29,33)(H,26,30,32)
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n/an/a 356n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402402
PNG
(US10329282, Compound TDI01426)
Show SMILES CN(CC(F)(F)F)C(=O)c1cc2ccc(cc2[nH]1)-c1ncc(F)c(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C25H19F4N7O/c1-36(13-25(27,28)29)24(37)21-8-15-2-3-16(9-20(15)34-21)22-30-12-19(26)23(35-22)33-18-6-4-14(5-7-18)17-10-31-32-11-17/h2-12,34H,13H2,1H3,(H,31,32)(H,30,33,35)
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n/an/a 365n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402342
PNG
(US10329282, Compound TDI01215)
Show SMILES O=C(Nc1ccccc1)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C26H19N7O/c34-26(30-19-4-2-1-3-5-19)23-13-16-6-7-17(14-22(16)31-23)25-27-11-10-24(32-25)29-20-8-9-21-18(12-20)15-28-33-21/h1-15,31H,(H,28,33)(H,30,34)(H,27,29,32)
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n/an/a 382n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402393
PNG
(US10329282, Compound TDI01408)
Show SMILES CCNC(=O)c1cc2cc(ccc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C24H21N7O/c1-2-25-24(32)21-12-17-11-16(5-8-20(17)30-21)23-26-10-9-22(31-23)29-19-6-3-15(4-7-19)18-13-27-28-14-18/h3-14,30H,2H2,1H3,(H,25,32)(H,27,28)(H,26,29,31)
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n/an/a 400n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402368
PNG
(US10329282, Compound TDI01320)
Show SMILES CN1CCC2(CC1)CCN(CC2)C(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C30H32N8O/c1-37-12-7-30(8-13-37)9-14-38(15-10-30)29(39)26-17-20-2-3-21(18-25(20)34-26)28-31-11-6-27(35-28)33-23-4-5-24-22(16-23)19-32-36-24/h2-6,11,16-19,34H,7-10,12-15H2,1H3,(H,32,36)(H,31,33,35)
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n/an/a 410n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402387
PNG
(US10329282, Compound TDI01379)
Show SMILES CNC(=O)c1cc2ccc(cc2[nH]1)-c1nc(Nc2ccc(cc2)-c2cn[nH]c2)c2sccc2n1
Show InChI InChI=1S/C25H19N7OS/c1-26-25(33)21-10-15-2-3-16(11-20(15)30-21)23-31-19-8-9-34-22(19)24(32-23)29-18-6-4-14(5-7-18)17-12-27-28-13-17/h2-13,30H,1H3,(H,26,33)(H,27,28)(H,29,31,32)
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n/an/a 411n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402300
PNG
(US10329282, Compound TDI01110)
Show SMILES CN(C)C(=O)c1cc2ccc(cc2s1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C22H18N6OS/c1-28(2)22(29)19-10-13-3-4-14(11-18(13)30-19)21-23-8-7-20(26-21)25-16-5-6-17-15(9-16)12-24-27-17/h3-12H,1-2H3,(H,24,27)(H,23,25,26)
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n/an/a 422n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402377
PNG
(US10329282, Compound TDI01343)
Show SMILES CN1CCN(CC1)C(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C27H26N8O/c1-34-10-12-35(13-11-34)27(36)24-14-19-2-3-20(15-23(19)32-24)26-28-9-8-25(33-26)31-22-6-4-18(5-7-22)21-16-29-30-17-21/h2-9,14-17,32H,10-13H2,1H3,(H,29,30)(H,28,31,33)
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n/an/a 436n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM399173
PNG
(US10323023, Compound TDI01164)
Show SMILES O=C(Nc1ccnnc1)c1cc2ccc(cc2[nH]1)-c1nc(Nc2ccc3[nH]ncc3c2)cc2nccn12
Show InChI InChI=1S/C26H18N10O/c37-26(32-19-5-6-28-29-14-19)22-10-15-1-2-16(11-21(15)33-22)25-34-23(12-24-27-7-8-36(24)25)31-18-3-4-20-17(9-18)13-30-35-20/h1-14,31,33H,(H,30,35)(H,28,32,37)
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n/an/a 438n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402299
PNG
(US10329282, Compound TDI01109)
Show SMILES CNC(=O)c1cc2ccc(cc2s1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C21H16N6OS/c1-22-21(28)18-9-12-2-3-13(10-17(12)29-18)20-23-7-6-19(26-20)25-15-4-5-16-14(8-15)11-24-27-16/h2-11H,1H3,(H,22,28)(H,24,27)(H,23,25,26)
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BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402361
PNG
(US10329282, Compound TDI01299)
Show SMILES CC(C)OC(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C25H22N6O2/c1-15(2)33-25(32)22-11-17-3-4-18(12-21(17)30-22)24-26-10-9-23(31-24)29-20-7-5-16(6-8-20)19-13-27-28-14-19/h3-15,30H,1-2H3,(H,27,28)(H,26,29,31)
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BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402362
PNG
(US10329282, Compound TDI01311)
Show SMILES O=C(Nc1ccccn1)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C25H18N8O/c34-25(32-22-3-1-2-9-26-22)21-12-15-4-5-16(13-20(15)30-21)24-27-10-8-23(31-24)29-18-6-7-19-17(11-18)14-28-33-19/h1-14,30H,(H,28,33)(H,26,32,34)(H,27,29,31)
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n/an/a 465n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402306
PNG
(US10329282, Compound TDI01121)
Show SMILES CC(C)NC(=O)c1cc2ccc(cc2s1)-c1nc(Nc2ccc3[nH]ncc3c2)cc(OCCN(C)C)n1
Show InChI InChI=1S/C27H29N7O2S/c1-16(2)29-27(35)23-12-17-5-6-18(13-22(17)37-23)26-31-24(14-25(32-26)36-10-9-34(3)4)30-20-7-8-21-19(11-20)15-28-33-21/h5-8,11-16H,9-10H2,1-4H3,(H,28,33)(H,29,35)(H,30,31,32)
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n/an/a 470n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402370
PNG
(US10329282, Compound TDI01327)
Show SMILES CC(C)NC(=O)c1ccc2ccc(cc2n1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1
Show InChI InChI=1S/C24H21N7O/c1-14(2)27-24(32)20-7-5-15-3-4-16(12-21(15)29-20)23-25-10-9-22(30-23)28-18-6-8-19-17(11-18)13-26-31-19/h3-14H,1-2H3,(H,26,31)(H,27,32)(H,25,28,30)
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n/an/a 472n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402371
PNG
(US10329282, Compound TDI01330)
Show SMILES O=C(N1CCC1)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C25H21N7O/c33-25(32-10-1-11-32)22-12-17-2-3-18(13-21(17)30-22)24-26-9-8-23(31-24)29-20-6-4-16(5-7-20)19-14-27-28-15-19/h2-9,12-15,30H,1,10-11H2,(H,27,28)(H,26,29,31)
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BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402397
PNG
(US10329282, Compound TDI01420)
Show SMILES CN(C1CCC1)C(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1S/C27H25N7O/c1-34(22-3-2-4-22)27(35)24-13-18-5-6-19(14-23(18)32-24)26-28-12-11-25(33-26)31-21-9-7-17(8-10-21)20-15-29-30-16-20/h5-16,22,32H,2-4H2,1H3,(H,29,30)(H,28,31,33)
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n/an/a 477n/an/an/an/an/an/a



BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
ROCK2 (aa 1-119)


(Homo sapiens (Human))
BDBM402413
PNG
(US10329282, Compound TDI01852)
Show SMILES OC[C@H]1CN(CCO1)C(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Show InChI InChI=1/C27H25N7O3/c35-16-22-15-34(9-10-37-22)27(36)24-11-18-1-2-19(12-23(18)32-24)26-28-8-7-25(33-26)31-21-5-3-17(4-6-21)20-13-29-30-14-20/h1-8,11-14,22,32,35H,9-10,15-16H2,(H,29,30)(H,28,31,33)/t22-/s2
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BEIJING TIDE PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...


US Patent US10329282 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%