BindingDB logo
myBDB logout

Patent code US10329286

Compile Data Set for Download or QSAR
Found 11 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
M1H (aa 187-462)


(Homo sapiens (Human))
BDBM402333
PNG
(6-(3-(2-chloro-4-((5- cyclopropyl-3-(2,6- dichloro...)
Show SMILES OC1(CN(C1)c1ccc(OC=O)c(n1)C(F)(F)F)c1ccc(OCc2c(onc2-c2c(Cl)cccc2Cl)C2CC2)cc1Cl
Show InChI InChI=1S/C29H21Cl3F3N3O5/c30-19-2-1-3-20(31)24(19)25-17(26(43-37-25)15-4-5-15)11-41-16-6-7-18(21(32)10-16)28(40)12-38(13-28)23-9-8-22(42-14-39)27(36-23)29(33,34)35/h1-3,6-10,14-15,40H,4-5,11-13H2
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.10n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR was performed as follow...


US Patent US10329286 (2019)

More data for this
Ligand-Target Pair
M1H (aa 187-462)


(Homo sapiens (Human))
BDBM402334
PNG
(6-(3-(2-chloro-4-((5- cyclopropyl-3-(2,6- dichloro...)
Show SMILES Cc1cc(ncc1OC=O)N1CC(O)(C1)c1ccc(OCc2c(onc2-c2c(Cl)cccc2Cl)C2CC2)cc1Cl
Show InChI InChI=1S/C29H24Cl3N3O5/c1-16-9-25(33-11-24(16)39-15-36)35-13-29(37,14-35)20-8-7-18(10-23(20)32)38-12-19-27(34-40-28(19)17-5-6-17)26-21(30)3-2-4-22(26)31/h2-4,7-11,15,17,37H,5-6,12-14H2,1H3
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 8.5n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR was performed as follow...


US Patent US10329286 (2019)

More data for this
Ligand-Target Pair
M1H (aa 187-462)


(Homo sapiens (Human))
BDBM402336
PNG
(6-(3-(2-chloro-4-((5- cyclopropyl-3-(2,6- dimethox...)
Show SMILES COc1cccc(OC)c1-c1noc(C2CC2)c1COc1ccc(c(Cl)c1)C1(O)CN(C1)c1ncc(cc1F)C(O)=O
Show InChI InChI=1S/C30H27ClFN3O7/c1-39-23-4-3-5-24(40-2)25(23)26-19(27(42-34-26)16-6-7-16)13-41-18-8-9-20(21(31)11-18)30(38)14-35(15-30)28-22(32)10-17(12-33-28)29(36)37/h3-5,8-12,16,38H,6-7,13-15H2,1-2H3,(H,36,37)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 15n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR was performed as follow...


US Patent US10329286 (2019)

More data for this
Ligand-Target Pair
M1H (aa 187-462)


(Homo sapiens (Human))
BDBM402341
PNG
(6-(3-(2-chloro-4-((4- cyclopropyl-1-(2,6- dichloro...)
Show SMILES OC(=O)c1cnc(N2CC(O)(C2)c2ccc(OCc3c(cnn3-c3c(Cl)cccc3Cl)C3CC3)cc2Cl)c(F)c1
Show InChI InChI=1S/C28H22Cl3FN4O4/c29-20-2-1-3-21(30)25(20)36-24(18(11-34-36)15-4-5-15)12-40-17-6-7-19(22(31)9-17)28(39)13-35(14-28)26-23(32)8-16(10-33-26)27(37)38/h1-3,6-11,15,39H,4-5,12-14H2,(H,37,38)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.80n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR was performed as follow...


US Patent US10329286 (2019)

More data for this
Ligand-Target Pair
M1H (aa 187-462)


(Homo sapiens (Human))
BDBM402305
PNG
(6-(3-(2-chloro-4-((5- cyclopropyl-3-(3,5- dichloro...)
Show SMILES OC(=O)c1ccc(nc1)N1CC(O)(C1)c1ccc(OCc2c(onc2-c2c(Cl)cncc2Cl)C2CC2)cc1Cl
Show InChI InChI=1S/C27H21Cl3N4O5/c28-19-7-16(4-5-18(19)27(37)12-34(13-27)22-6-3-15(8-32-22)26(35)36)38-11-17-24(33-39-25(17)14-1-2-14)23-20(29)9-31-10-21(23)30/h3-10,14,37H,1-2,11-13H2,(H,35,36)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 6.10n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR was performed as follow...


US Patent US10329286 (2019)

More data for this
Ligand-Target Pair
M1H (aa 187-462)


(Homo sapiens (Human))
BDBM402321
PNG
(6-(3-(2-chloro-4-((5- cyclopropyl-3-(2,6- dichloro...)
Show SMILES OC1(CN(C1)c1ccc(OC=O)cn1)c1ccc(OCc2c(onc2-c2c(Cl)cccc2Cl)C2CC2)cc1Cl
Show InChI InChI=1S/C28H22Cl3N3O5/c29-21-2-1-3-22(30)25(21)26-19(27(39-33-26)16-4-5-16)12-37-17-6-8-20(23(31)10-17)28(36)13-34(14-28)24-9-7-18(11-32-24)38-15-35/h1-3,6-11,15-16,36H,4-5,12-14H2
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.60n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR was performed as follow...


US Patent US10329286 (2019)

More data for this
Ligand-Target Pair
M1H (aa 187-462)


(Homo sapiens (Human))
BDBM402327
PNG
(6-(3-(2-chloro-4-((5- cyclopropyl-3-(2,6- dichloro...)
Show SMILES Cc1cc(OC=O)cnc1N1CC(O)(C1)c1ccc(OCc2c(onc2-c2c(Cl)cccc2Cl)C2CC2)cc1Cl
Show InChI InChI=1S/C29H24Cl3N3O5/c1-16-9-19(39-15-36)11-33-28(16)35-13-29(37,14-35)21-8-7-18(10-24(21)32)38-12-20-26(34-40-27(20)17-5-6-17)25-22(30)3-2-4-23(25)31/h2-4,7-11,15,17,37H,5-6,12-14H2,1H3
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.90n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR was performed as follow...


US Patent US10329286 (2019)

More data for this
Ligand-Target Pair
M1H (aa 187-462)


(Homo sapiens (Human))
BDBM402332
PNG
(6-(3-(2-chloro-4-((5- cyclopropyl-3-(2,6- dichloro...)
Show SMILES OC1(CN(C1)c1ncc(OC=O)cc1F)c1ccc(OCc2c(onc2-c2c(Cl)cccc2Cl)C2CC2)cc1Cl
Show InChI InChI=1S/C28H21Cl3FN3O5/c29-20-2-1-3-21(30)24(20)25-18(26(40-34-25)15-4-5-15)11-38-16-6-7-19(22(31)8-16)28(37)12-35(13-28)27-23(32)9-17(10-33-27)39-14-36/h1-3,6-10,14-15,37H,4-5,11-13H2
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 4.80n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR was performed as follow...


US Patent US10329286 (2019)

More data for this
Ligand-Target Pair
M1H (aa 187-462)


(Homo sapiens (Human))
BDBM402337
PNG
(6-(3-(2-chloro-4-((5- cyclopropyl-3-(2,6-dichloro-...)
Show SMILES Cc1cc(Cl)c(-c2noc(C3CC3)c2COc2ccc(c(Cl)c2)C2(O)CN(C2)c2ncc(cc2F)C(O)=O)c(Cl)c1
Show InChI InChI=1S/C29H23Cl3FN3O5/c1-14-6-21(31)24(22(32)7-14)25-18(26(41-35-25)15-2-3-15)11-40-17-4-5-19(20(30)9-17)29(39)12-36(13-29)27-23(33)8-16(10-34-27)28(37)38/h4-10,15,39H,2-3,11-13H2,1H3,(H,37,38)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 57n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR was performed as follow...


US Patent US10329286 (2019)

More data for this
Ligand-Target Pair
M1H (aa 187-462)


(Homo sapiens (Human))
BDBM402340
PNG
(6-(3-(2-chloro-4-((5- cyclopropyl-3-(3,5- dichloro...)
Show SMILES OC(=O)c1cnc(N2CC(O)(C2)c2ccc(OCc3c(onc3-c3c(Cl)cncc3Cl)C3CC3)cc2Cl)c(F)c1
Show InChI InChI=1S/C27H20Cl3FN4O5/c28-18-6-15(3-4-17(18)27(38)11-35(12-27)25-21(31)5-14(7-33-25)26(36)37)39-10-16-23(34-40-24(16)13-1-2-13)22-19(29)8-32-9-20(22)30/h3-9,13,38H,1-2,10-12H2,(H,36,37)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.40n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR was performed as follow...


US Patent US10329286 (2019)

More data for this
Ligand-Target Pair
M1H (aa 187-462)


(Homo sapiens (Human))
BDBM402326
PNG
(6-(3-(2-chloro-4-((5- cyclopropyl-3-(2,6- dichloro...)
Show SMILES Cc1nc(ccc1OC=O)N1CC(O)(C1)c1ccc(OCc2c(onc2-c2c(Cl)cccc2Cl)C2CC2)cc1Cl
Show InChI InChI=1S/C29H24Cl3N3O5/c1-16-24(39-15-36)9-10-25(33-16)35-13-29(37,14-35)20-8-7-18(11-23(20)32)38-12-19-27(34-40-28(19)17-5-6-17)26-21(30)3-2-4-22(26)31/h2-4,7-11,15,17,37H,5-6,12-14H2,1H3
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 4.40n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR was performed as follow...


US Patent US10329286 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%