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Patent code US10329295

Compile Data Set for Download or QSAR
Found 163 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402846
PNG
(N-[3-(difluoromethyl)-1- methyl-1H-pyrazol-4-yl]- ...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@H]4CNC[C@@H](F)C4)nn23)c(n1)C(F)F
Show InChI InChI=1S/C17H19F3N8O/c1-27-8-12(14(25-27)15(19)20)24-16(29)13-3-2-11-7-22-17(26-28(11)13)23-10-4-9(18)5-21-6-10/h2-3,7-10,15,21H,4-6H2,1H3,(H,23,26)(H,24,29)/t9-,10+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402851
PNG
(N-[3-(difluoromethyl)-1- methyl-1H-pyrazol-4-yl]- ...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CNC[C@@H](F)C4)nn23)c(n1)C(F)F
Show InChI InChI=1S/C17H19F3N8O/c1-27-8-12(14(25-27)15(19)20)24-16(29)13-3-2-11-7-22-17(26-28(11)13)23-10-4-9(18)5-21-6-10/h2-3,7-10,15,21H,4-6H2,1H3,(H,23,26)(H,24,29)/t9-,10-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402809
PNG
(2-(3,8- diazabicyclo[3.2.1]oct-8- yl)-N-[3-(difluo...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2C3CCC2CNC3)c(n1)C(F)F
Show InChI InChI=1S/C18H20F2N8O/c1-26-9-13(15(24-26)16(19)20)23-17(29)14-5-4-12-8-22-18(25-28(12)14)27-10-2-3-11(27)7-21-6-10/h4-5,8-11,16,21H,2-3,6-7H2,1H3,(H,23,29)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402843
PNG
(2-[(3R,5R)-3-amino-5- fluoropiperidin-1-yl]-N-[3- ...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2C[C@H](N)C[C@@H](F)C2)c(n1)C(F)F
Show InChI InChI=1S/C17H19F3N8O/c1-26-8-12(14(24-26)15(19)20)23-16(29)13-3-2-11-5-22-17(25-28(11)13)27-6-9(18)4-10(21)7-27/h2-3,5,8-10,15H,4,6-7,21H2,1H3,(H,23,29)/t9-,10-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402695
PNG
(2-[(3R)-3-aminopiperidin- 1-yl]-N-[3- (difluoromet...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2CCC[C@@H](N)C2)c(n1)C(F)F
Show InChI InChI=1S/C17H20F2N8O/c1-25-9-12(14(23-25)15(18)19)22-16(28)13-5-4-11-7-21-17(24-27(11)13)26-6-2-3-10(20)8-26/h4-5,7,9-10,15H,2-3,6,8,20H2,1H3,(H,22,28)/t10-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402850
PNG
(2-[(3R,5S)-3-amino-5- fluoropiperidin-1-yl]-N-[3- ...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2C[C@H](N)C[C@H](F)C2)c(n1)C(F)F
Show InChI InChI=1S/C17H19F3N8O/c1-26-8-12(14(24-26)15(19)20)23-16(29)13-3-2-11-5-22-17(25-28(11)13)27-6-9(18)4-10(21)7-27/h2-3,5,8-10,15H,4,6-7,21H2,1H3,(H,23,29)/t9-,10+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50130662
PNG
(CHEMBL3634511 | US10329295, Example 90)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCCNC4)nn23)c(n1)C(F)F
Show InChI InChI=1/C18H22F2N8O/c1-27-10-13(15(25-27)16(19)20)24-17(29)14-6-5-12-9-22-18(26-28(12)14)23-11-4-2-3-7-21-8-11/h5-6,9-11,16,21H,2-4,7-8H2,1H3,(H,23,26)(H,24,29)/t11-/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402838
PNG
(2-[(3S,5R)-3-amino-5- fluoropiperidin-1-yl]-N-[3- ...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2C[C@@H](N)C[C@@H](F)C2)c(n1)C(F)F
Show InChI InChI=1S/C17H19F3N8O/c1-26-8-12(14(24-26)15(19)20)23-16(29)13-3-2-11-5-22-17(25-28(11)13)27-6-9(18)4-10(21)7-27/h2-3,5,8-10,15H,4,6-7,21H2,1H3,(H,23,29)/t9-,10+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402844
PNG
(2-[(3S,5S)-3-amino-5- fluoropiperidin-1-yl]-N-[3- ...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2C[C@@H](N)C[C@H](F)C2)c(n1)C(F)F
Show InChI InChI=1S/C17H19F3N8O/c1-26-8-12(14(24-26)15(19)20)23-16(29)13-3-2-11-5-22-17(25-28(11)13)27-6-9(18)4-10(21)7-27/h2-3,5,8-10,15H,4,6-7,21H2,1H3,(H,23,29)/t9-,10-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402812
PNG
(N-(3-cyano-1-methyl-1H- pyrazol-4-yl)-2-[(3R)- pip...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCNC4)nn23)c(n1)C#N
Show InChI InChI=1S/C17H19N9O/c1-25-10-14(13(7-18)23-25)22-16(27)15-5-4-12-9-20-17(24-26(12)15)21-11-3-2-6-19-8-11/h4-5,9-11,19H,2-3,6,8H2,1H3,(H,21,24)(H,22,27)/t11-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402836
PNG
(2-[(3R,5R)-3-amino-5- fluoropiperidin-1-yl]-N-[1- ...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2C[C@H](N)C[C@@H](F)C2)c(n1)C(F)(F)F
Show InChI InChI=1S/C17H18F4N8O/c1-27-8-12(14(25-27)17(19,20)21)24-15(30)13-3-2-11-5-23-16(26-29(11)13)28-6-9(18)4-10(22)7-28/h2-3,5,8-10H,4,6-7,22H2,1H3,(H,24,30)/t9-,10-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402486
PNG
(2-[(3R)-3-aminopiperidin- 1-yl]-N-[1-methyl-3- (tr...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2CCC[C@@H](N)C2)c(n1)C(F)(F)F
Show InChI InChI=1S/C17H19F3N8O/c1-26-9-12(14(24-26)17(18,19)20)23-15(29)13-5-4-11-7-22-16(25-28(11)13)27-6-2-3-10(21)8-27/h4-5,7,9-10H,2-3,6,8,21H2,1H3,(H,23,29)/t10-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50130690
PNG
(CHEMBL3634507 | US10329295, Example 16)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCNC4)nn23)c(n1)C(F)F
Show InChI InChI=1/C17H20F2N8O/c1-26-9-12(14(24-26)15(18)19)23-16(28)13-5-4-11-8-21-17(25-27(11)13)22-10-3-2-6-20-7-10/h4-5,8-10,15,20H,2-3,6-7H2,1H3,(H,22,25)(H,23,28)/t10-/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50130666
PNG
(CHEMBL3634513 | US10329295, Example 25)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCC[C@@H]4N)nn23)c(Cl)n1
Show InChI InChI=1/C17H21ClN8O/c1-25-9-13(15(18)23-25)21-16(27)14-7-6-10-8-20-17(24-26(10)14)22-12-5-3-2-4-11(12)19/h6-9,11-12H,2-5,19H2,1H3,(H,21,27)(H,22,24)/t11-,12+/s2
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US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402759
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(3-bromo-...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCC[C@@H]4N)nn23)c(Br)n1
Show InChI InChI=1S/C17H21BrN8O/c1-25-9-13(15(18)23-25)21-16(27)14-7-6-10-8-20-17(24-26(10)14)22-12-5-3-2-4-11(12)19/h6-9,11-12H,2-5,19H2,1H3,(H,21,27)(H,22,24)/t11-,12+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402811
PNG
(2-[(3S)-3-aminopiperidin- 1-yl]-N-(3-cyano-1- meth...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2CCC[C@H](N)C2)c(n1)C#N
Show InChI InChI=1S/C17H19N9O/c1-24-10-14(13(7-18)22-24)21-16(27)15-5-4-12-8-20-17(23-26(12)15)25-6-2-3-11(19)9-25/h4-5,8,10-11H,2-3,6,9,19H2,1H3,(H,21,27)/t11-/m0/s1
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Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402784
PNG
(2-[(3S)- or (3R)-azepan-3- ylamino]-N-[3- (difluor...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@H]4CCCCNC4)nn23)c(n1)C(F)F
Show InChI InChI=1S/C18H22F2N8O/c1-27-10-13(15(25-27)16(19)20)24-17(29)14-6-5-12-9-22-18(26-28(12)14)23-11-4-2-3-7-21-8-11/h5-6,9-11,16,21H,2-4,7-8H2,1H3,(H,23,26)(H,24,29)/t11-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402696
PNG
(2-(azepan-3-ylamino)-N- [3-(difluoromethyl)-1- met...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(NC4CCCCNC4)nn23)c(n1)C(F)F
Show InChI InChI=1S/C18H22F2N8O/c1-27-10-13(15(25-27)16(19)20)24-17(29)14-6-5-12-9-22-18(26-28(12)14)23-11-4-2-3-7-21-8-11/h5-6,9-11,16,21H,2-4,7-8H2,1H3,(H,23,26)(H,24,29)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402852
PNG
(N-[3-(difluoromethyl)-1- methyl-1H-pyrazol-4-yl]- ...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@H]4CNC[C@H](F)C4)nn23)c(n1)C(F)F
Show InChI InChI=1S/C17H19F3N8O/c1-27-8-12(14(25-27)15(19)20)24-16(29)13-3-2-11-7-22-17(26-28(11)13)23-10-4-9(18)5-21-6-10/h2-3,7-10,15,21H,4-6H2,1H3,(H,23,26)(H,24,29)/t9-,10-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402813
PNG
(2-[(3R)-3-aminopiperidin- 1-yl]-N-(3-cyano-1- meth...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2CCC[C@@H](N)C2)c(n1)C#N
Show InChI InChI=1S/C17H19N9O/c1-24-10-14(13(7-18)22-24)21-16(27)15-5-4-12-8-20-17(23-26(12)15)25-6-2-3-11(19)9-25/h4-5,8,10-11H,2-3,6,9,19H2,1H3,(H,21,27)/t11-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50130669
PNG
(CHEMBL3634614 | US10329295, Example 35)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCC[C@@H]4N)nn23)c(n1)C#N
Show InChI InChI=1/C18H21N9O/c1-26-10-15(14(8-19)24-26)22-17(28)16-7-6-11-9-21-18(25-27(11)16)23-13-5-3-2-4-12(13)20/h6-7,9-10,12-13H,2-5,20H2,1H3,(H,22,28)(H,23,25)/t12-,13+/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402698
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(2-cyanot...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc2ccc(C(=O)Nc3ccsc3C#N)n2n1
Show InChI InChI=1S/C18H19N7OS/c19-9-16-14(7-8-27-16)22-17(26)15-6-5-11-10-21-18(24-25(11)15)23-13-4-2-1-3-12(13)20/h5-8,10,12-13H,1-4,20H2,(H,22,26)(H,23,24)/t12-,13+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402776
PNG
(2-(3,8- diazabicyclo[3.2.1]oct-3- yl)-N-[3-[difluo...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2CC3CCC(C2)N3)c(n1)C(F)F
Show InChI InChI=1S/C18H20F2N8O/c1-26-9-13(15(24-26)16(19)20)23-17(29)14-5-4-12-6-21-18(25-28(12)14)27-7-10-2-3-11(8-27)22-10/h4-6,9-11,16,22H,2-3,7-8H2,1H3,(H,23,29)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50130676
PNG
(CHEMBL3634378 | US10329295, Example 2)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCC[C@@H]4N)nn23)c(n1)C(F)(F)F
Show InChI InChI=1/C18H21F3N8O/c1-28-9-13(15(26-28)18(19,20)21)24-16(30)14-7-6-10-8-23-17(27-29(10)14)25-12-5-3-2-4-11(12)22/h6-9,11-12H,2-5,22H2,1H3,(H,24,30)(H,25,27)/t11-,12+/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402800
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(4-chloro...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc2ccc(C(=O)Nc3cscc3Cl)n2n1
Show InChI InChI=1S/C17H19ClN6OS/c18-11-8-26-9-14(11)21-16(25)15-6-5-10-7-20-17(23-24(10)15)22-13-4-2-1-3-12(13)19/h5-9,12-13H,1-4,19H2,(H,21,25)(H,22,23)/t12-,13+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50130686
PNG
(CHEMBL3634503 | US10329295, Example 5)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCNC4)nn23)c(n1)C(F)(F)F
Show InChI InChI=1/C17H19F3N8O/c1-27-9-12(14(25-27)17(18,19)20)24-15(29)13-5-4-11-8-22-16(26-28(11)13)23-10-3-2-6-21-7-10/h4-5,8-10,21H,2-3,6-7H2,1H3,(H,23,26)(H,24,29)/t10-/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402697
PNG
(2-(5,8-diazaspiro[2.6]non- 5-yl)-N-[3- (difluorome...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2CCNCC3(CC3)C2)c(n1)C(F)F
Show InChI InChI=1S/C19H22F2N8O/c1-27-9-13(15(25-27)16(20)21)24-17(30)14-3-2-12-8-23-18(26-29(12)14)28-7-6-22-10-19(11-28)4-5-19/h2-3,8-9,16,22H,4-7,10-11H2,1H3,(H,24,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402807
PNG
(2-[(1S,5R)- or (1R,5S)-3,6- diazabicyclo[3.2.1]oct...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2C[C@H]3C[C@@H]2CNC3)c(n1)C(F)F
Show InChI InChI=1S/C18H20F2N8O/c1-26-9-13(15(24-26)16(19)20)23-17(29)14-3-2-11-7-22-18(25-28(11)14)27-8-10-4-12(27)6-21-5-10/h2-3,7,9-10,12,16,21H,4-6,8H2,1H3,(H,23,29)/t10-,12+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402352
PNG
(N-[1-methyl-3- (trifluoromethyl)-1H- pyrazol-4-yl]...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2CCNCC2)c(n1)C(F)(F)F
Show InChI InChI=1S/C16H17F3N8O/c1-25-9-11(13(23-25)16(17,18)19)22-14(28)12-3-2-10-8-21-15(24-27(10)12)26-6-4-20-5-7-26/h2-3,8-9,20H,4-7H2,1H3,(H,22,28)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402826
PNG
(2-{[(1S,2R)- or (1R,2S)-2- amino-4,4- difluorocycl...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCC(F)(F)C[C@@H]4N)nn23)c(n1)C(F)F
Show InChI InChI=1S/C18H20F4N8O/c1-29-8-12(14(27-29)15(19)20)25-16(31)13-3-2-9-7-24-17(28-30(9)13)26-11-4-5-18(21,22)6-10(11)23/h2-3,7-8,10-11,15H,4-6,23H2,1H3,(H,25,31)(H,26,28)/t10-,11+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402723
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(2-chloro...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc2ccc(C(=O)Nc3ccsc3Cl)n2n1
Show InChI InChI=1S/C17H19ClN6OS/c18-15-13(7-8-26-15)21-16(25)14-6-5-10-9-20-17(23-24(10)14)22-12-4-2-1-3-11(12)19/h5-9,11-12H,1-4,19H2,(H,21,25)(H,22,23)/t11-,12+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50130683
PNG
(CHEMBL3634501 | US10329295, Example 140)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CC(F)(F)CC[C@@H]4N)nn23)c(n1)C(F)F
Show InChI InChI=1/C18H20F4N8O/c1-29-8-12(14(27-29)15(19)20)25-16(31)13-3-2-9-7-24-17(28-30(9)13)26-11-6-18(21,22)5-4-10(11)23/h2-3,7-8,10-11,15H,4-6,23H2,1H3,(H,25,31)(H,26,28)/t10-,11+/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402832
PNG
(N-(4-cyanothiophen-3-yl)- 2-[(3R)-piperidin-3- yla...)
Show SMILES O=C(Nc1cscc1C#N)c1ccc2cnc(N[C@@H]3CCCNC3)nn12
Show InChI InChI=1S/C17H17N7OS/c18-6-11-9-26-10-14(11)22-16(25)15-4-3-13-8-20-17(23-24(13)15)21-12-2-1-5-19-7-12/h3-4,8-10,12,19H,1-2,5,7H2,(H,21,23)(H,22,25)/t12-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402733
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(2- chlor...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc2ccc(C(=O)Nc3ccccc3Cl)n2n1
Show InChI InChI=1S/C19H21ClN6O/c20-13-5-1-3-7-15(13)23-18(27)17-10-9-12-11-22-19(25-26(12)17)24-16-8-4-2-6-14(16)21/h1,3,5,7,9-11,14,16H,2,4,6,8,21H2,(H,23,27)(H,24,25)/t14-,16+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402819
PNG
(2-{[(1S,2R)- or (1R,2S)-2- amino-5,5- difluorocycl...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CC(F)(F)CC[C@@H]4N)nn23)c(n1)C(F)(F)F
Show InChI InChI=1S/C18H19F5N8O/c1-30-8-12(14(28-30)18(21,22)23)26-15(32)13-3-2-9-7-25-16(29-31(9)13)27-11-6-17(19,20)5-4-10(11)24/h2-3,7-8,10-11H,4-6,24H2,1H3,(H,26,32)(H,27,29)/t10-,11+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402765
PNG
(2-[(3S)- or (3R)-azepan-3- ylamino]-N-[1-methyl-3-...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCCNC4)nn23)c(n1)C(F)(F)F
Show InChI InChI=1S/C18H21F3N8O/c1-28-10-13(15(26-28)18(19,20)21)25-16(30)14-6-5-12-9-23-17(27-29(12)14)24-11-4-2-3-7-22-8-11/h5-6,9-11,22H,2-4,7-8H2,1H3,(H,24,27)(H,25,30)/t11-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402517
PNG
(2-(azepan-3-ylamino)-N- [1-methyl-3- (trifluoromet...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(NC4CCCCNC4)nn23)c(n1)C(F)(F)F
Show InChI InChI=1S/C18H21F3N8O/c1-28-10-13(15(26-28)18(19,20)21)25-16(30)14-6-5-12-9-23-17(27-29(12)14)24-11-4-2-3-7-22-8-11/h5-6,9-11,22H,2-4,7-8H2,1H3,(H,24,27)(H,25,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402848
PNG
(2-{[(3S,5S)-5- fluoropiperidin-3- yl]amino}-N-[1-m...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CNC[C@@H](F)C4)nn23)c(n1)C(F)(F)F
Show InChI InChI=1S/C17H18F4N8O/c1-28-8-12(14(26-28)17(19,20)21)25-15(30)13-3-2-11-7-23-16(27-29(11)13)24-10-4-9(18)5-22-6-10/h2-3,7-10,22H,4-6H2,1H3,(H,24,27)(H,25,30)/t9-,10-/m0/s1
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Merck Sharp & Dohme Corp.

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Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402833
PNG
(N-(2-cyanothiophen-3-yl)- 2-[(3R)-piperidin-3- yla...)
Show SMILES O=C(Nc1ccsc1C#N)c1ccc2cnc(N[C@@H]3CCCNC3)nn12
Show InChI InChI=1S/C17H17N7OS/c18-8-15-13(5-7-26-15)22-16(25)14-4-3-12-10-20-17(23-24(12)14)21-11-2-1-6-19-9-11/h3-5,7,10-11,19H,1-2,6,9H2,(H,21,23)(H,22,25)/t11-/m1/s1
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Merck Sharp & Dohme Corp.

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Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402588
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(4-cyanot...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc2ccc(C(=O)Nc3cscc3C#N)n2n1
Show InChI InChI=1S/C18H19N7OS/c19-7-11-9-27-10-15(11)22-17(26)16-6-5-12-8-21-18(24-25(12)16)23-14-4-2-1-3-13(14)20/h5-6,8-10,13-14H,1-4,20H2,(H,22,26)(H,23,24)/t13-,14+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402735
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-[4- (difl...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc2ccc(C(=O)Nc3cscc3C(F)F)n2n1
Show InChI InChI=1S/C18H20F2N6OS/c19-16(20)11-8-28-9-14(11)23-17(27)15-6-5-10-7-22-18(25-26(10)15)24-13-4-2-1-3-12(13)21/h5-9,12-13,16H,1-4,21H2,(H,23,27)(H,24,25)/t12-,13+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402676
PNG
(N-[3-(difluoromethyl)-1- methyl-1H-pyrazol-4-yl]- ...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCC[C@@H]4O)nn23)c(n1)C(F)F
Show InChI InChI=1S/C18H21F2N7O2/c1-26-9-12(15(24-26)16(19)20)22-17(29)13-7-6-10-8-21-18(25-27(10)13)23-11-4-2-3-5-14(11)28/h6-9,11,14,16,28H,2-5H2,1H3,(H,22,29)(H,23,25)/t11-,14+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402789
PNG
(2-(3,8- diazabicyclo[3.2.1]oct-8- yl)-N-[1-methyl-...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2C3CCC2CNC3)c(n1)C(F)(F)F
Show InChI InChI=1S/C18H19F3N8O/c1-27-9-13(15(25-27)18(19,20)21)24-16(30)14-5-4-12-8-23-17(26-29(12)14)28-10-2-3-11(28)7-22-6-10/h4-5,8-11,22H,2-3,6-7H2,1H3,(H,24,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402762
PNG
(2-[(3S)- or (3R)-azepan-3- ylamino]-N-[1-methyl-3-...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@H]4CCCCNC4)nn23)c(n1)C(F)(F)F
Show InChI InChI=1S/C18H21F3N8O/c1-28-10-13(15(26-28)18(19,20)21)25-16(30)14-6-5-12-9-23-17(27-29(12)14)24-11-4-2-3-7-22-8-11/h5-6,9-11,22H,2-4,7-8H2,1H3,(H,24,27)(H,25,30)/t11-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402603
PNG
(2-(1,4-diazepan-1-yl)-N- [3-(difluoromethyl)-1- me...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2CCCNCC2)c(n1)C(F)F
Show InChI InChI=1S/C17H20F2N8O/c1-25-10-12(14(23-25)15(18)19)22-16(28)13-4-3-11-9-21-17(24-27(11)13)26-7-2-5-20-6-8-26/h3-4,9-10,15,20H,2,5-8H2,1H3,(H,22,28)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402599
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(4-bromot...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc2ccc(C(=O)Nc3cscc3Br)n2n1
Show InChI InChI=1S/C17H19BrN6OS/c18-11-8-26-9-14(11)21-16(25)15-6-5-10-7-20-17(23-24(10)15)22-13-4-2-1-3-12(13)19/h5-9,12-13H,1-4,19H2,(H,21,25)(H,22,23)/t12-,13+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402731
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(2-bromot...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc2ccc(C(=O)Nc3ccsc3Br)n2n1
Show InChI InChI=1S/C17H19BrN6OS/c18-15-13(7-8-26-15)21-16(25)14-6-5-10-9-20-17(23-24(10)14)22-12-4-2-1-3-11(12)19/h5-9,11-12H,1-4,19H2,(H,21,25)(H,22,23)/t11-,12+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402842
PNG
(N-[3-(difluoromethyl)-1- methyl-1H-pyrazol-4-yl]- ...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CNC[C@H](F)C4)nn23)c(n1)C(F)F
Show InChI InChI=1S/C17H19F3N8O/c1-27-8-12(14(25-27)15(19)20)24-16(29)13-3-2-11-7-22-17(26-28(11)13)23-10-4-9(18)5-21-6-10/h2-3,7-10,15,21H,4-6H2,1H3,(H,23,26)(H,24,29)/t9-,10+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402839
PNG
(2-[(3S)-3-aminopiperidin- 1-yl]-N-(2-cyanothiophen...)
Show SMILES N[C@H]1CCCN(C1)c1ncc2ccc(C(=O)Nc3ccsc3C#N)n2n1
Show InChI InChI=1S/C17H17N7OS/c18-8-15-13(5-7-26-15)21-16(25)14-4-3-12-9-20-17(22-24(12)14)23-6-1-2-11(19)10-23/h3-5,7,9,11H,1-2,6,10,19H2,(H,21,25)/t11-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402514
PNG
(2-(5,8-diazaspiro[2.6]non- 5-yl)-N-[1-methyl-3- (t...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2CCNCC3(CC3)C2)c(n1)C(F)(F)F
Show InChI InChI=1S/C19H21F3N8O/c1-28-9-13(15(26-28)19(20,21)22)25-16(31)14-3-2-12-8-24-17(27-30(12)14)29-7-6-23-10-18(11-29)4-5-18/h2-3,8-9,23H,4-7,10-11H2,1H3,(H,25,31)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402722
PNG
(2-(2,5- diazabicyclo[2.2.2]oct-2- yl)-N-[3-(difluo...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2CC3CCC2CN3)c(n1)C(F)F
Show InChI InChI=1S/C18H20F2N8O/c1-26-9-13(15(24-26)16(19)20)23-17(29)14-5-4-12-7-22-18(25-28(12)14)27-8-10-2-3-11(27)6-21-10/h4-5,7,9-11,16,21H,2-3,6,8H2,1H3,(H,23,29)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402753
PNG
(2-[(3S)- or (3R)-azepan-3- ylamino]-N-(2- cyanophe...)
Show SMILES O=C(Nc1ccccc1C#N)c1ccc2cnc(N[C@H]3CCCCNC3)nn12
Show InChI InChI=1S/C20H21N7O/c21-11-14-5-1-2-7-17(14)25-19(28)18-9-8-16-13-23-20(26-27(16)18)24-15-6-3-4-10-22-12-15/h1-2,5,7-9,13,15,22H,3-4,6,10,12H2,(H,24,26)(H,25,28)/t15-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402830
PNG
(2-[(3S)-3-aminopiperidin- 1-yl]-N-(4-cyanothiophen...)
Show SMILES N[C@H]1CCCN(C1)c1ncc2ccc(C(=O)Nc3cscc3C#N)n2n1
Show InChI InChI=1S/C17H17N7OS/c18-6-11-9-26-10-14(11)21-16(25)15-4-3-13-7-20-17(22-24(13)15)23-5-1-2-12(19)8-23/h3-4,7,9-10,12H,1-2,5,8,19H2,(H,21,25)/t12-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402847
PNG
(2-{[(3R,5S)-5- fluoropiperidin-3- yl]amino}-N-[1-m...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@H]4CNC[C@@H](F)C4)nn23)c(n1)C(F)(F)F
Show InChI InChI=1S/C17H18F4N8O/c1-28-8-12(14(26-28)17(19,20)21)25-15(30)13-3-2-11-7-23-16(27-29(11)13)24-10-4-9(18)5-22-6-10/h2-3,7-10,22H,4-6H2,1H3,(H,24,27)(H,25,30)/t9-,10+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402837
PNG
(2-[(3S,5S)-3-amino-5- fluoropiperidin-1-yl]-N-[1- ...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2C[C@@H](N)C[C@H](F)C2)c(n1)C(F)(F)F
Show InChI InChI=1S/C17H18F4N8O/c1-27-8-12(14(25-27)17(19,20)21)24-15(30)13-3-2-11-5-23-16(26-29(11)13)28-6-9(18)4-10(22)7-28/h2-3,5,8-10H,4,6-7,22H2,1H3,(H,24,30)/t9-,10-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402794
PNG
(2-[(1S,5S)- or (1R,5R)-3,6- diazabicyclo[3.2.1]oct...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2C[C@@H]3CN[C@@H](C3)C2)c(n1)C(F)F
Show InChI InChI=1S/C18H20F2N8O/c1-26-9-13(15(24-26)16(19)20)23-17(29)14-3-2-12-6-22-18(25-28(12)14)27-7-10-4-11(8-27)21-5-10/h2-3,6,9-11,16,21H,4-5,7-8H2,1H3,(H,23,29)/t10-,11-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402743
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(2- cyano...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc2ccc(C(=O)Nc3ccccc3C#N)n2n1
Show InChI InChI=1S/C20H21N7O/c21-11-13-5-1-3-7-16(13)24-19(28)18-10-9-14-12-23-20(26-27(14)18)25-17-8-4-2-6-15(17)22/h1,3,5,7,9-10,12,15,17H,2,4,6,8,22H2,(H,24,28)(H,25,26)/t15-,17+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402725
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(2- bromo...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc2ccc(C(=O)Nc3ccccc3Br)n2n1
Show InChI InChI=1S/C19H21BrN6O/c20-13-5-1-3-7-15(13)23-18(27)17-10-9-12-11-22-19(25-26(12)17)24-16-8-4-2-6-14(16)21/h1,3,5,7,9-11,14,16H,2,4,6,8,21H2,(H,23,27)(H,24,25)/t14-,16+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402802
PNG
(N-(3-cyano-1-methyl-1H- pyrazol-4-yl)-2-(3,8- diaz...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2C3CCC2CNC3)c(n1)C#N
Show InChI InChI=1S/C18H19N9O/c1-25-10-15(14(6-19)23-25)22-17(28)16-5-4-13-9-21-18(24-27(13)16)26-11-2-3-12(26)8-20-7-11/h4-5,9-12,20H,2-3,7-8H2,1H3,(H,22,28)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402808
PNG
(2-[(1S,5R)- or (1R,5S)-3,6- diazabicyclo[3.2.1]oct...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2C[C@@H]3C[C@H]2CNC3)c(n1)C(F)F
Show InChI InChI=1S/C18H20F2N8O/c1-26-9-13(15(24-26)16(19)20)23-17(29)14-3-2-11-7-22-18(25-28(11)14)27-8-10-4-12(27)6-21-5-10/h2-3,7,9-10,12,16,21H,4-6,8H2,1H3,(H,23,29)/t10-,12+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402815
PNG
(2-{[(1S,2R)- or (1R,2S)-2- amino-5,5- difluorocycl...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@H]4CC(F)(F)CC[C@H]4N)nn23)c(n1)C(F)(F)F
Show InChI InChI=1S/C18H19F5N8O/c1-30-8-12(14(28-30)18(21,22)23)26-15(32)13-3-2-9-7-25-16(29-31(9)13)27-11-6-17(19,20)5-4-10(11)24/h2-3,7-8,10-11H,4-6,24H2,1H3,(H,26,32)(H,27,29)/t10-,11+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402849
PNG
(2-{[(3R,5R)-5- fluoropiperidin-3- yl]amino}-N-[1-m...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@H]4CNC[C@H](F)C4)nn23)c(n1)C(F)(F)F
Show InChI InChI=1S/C17H18F4N8O/c1-28-8-12(14(26-28)17(19,20)21)25-15(30)13-3-2-11-7-23-16(27-29(11)13)24-10-4-9(18)5-22-6-10/h2-3,7-10,22H,4-6H2,1H3,(H,24,27)(H,25,30)/t9-,10-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402831
PNG
(2-[(3R)-3-aminopiperidin- 1-yl]-N-(4-cyanothiophen...)
Show SMILES N[C@@H]1CCCN(C1)c1ncc2ccc(C(=O)Nc3cscc3C#N)n2n1
Show InChI InChI=1S/C17H17N7OS/c18-6-11-9-26-10-14(11)21-16(25)15-4-3-13-7-20-17(22-24(13)15)23-5-1-2-12(19)8-23/h3-4,7,9-10,12H,1-2,5,8,19H2,(H,21,25)/t12-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402835
PNG
(2-[(3S,5R)-3-amino-5- fluoropiperidin-1-yl]-N-[1- ...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2C[C@@H](N)C[C@@H](F)C2)c(n1)C(F)(F)F
Show InChI InChI=1S/C17H18F4N8O/c1-27-8-12(14(25-27)17(19,20)21)24-15(30)13-3-2-11-5-23-16(26-29(11)13)28-6-9(18)4-10(22)7-28/h2-3,5,8-10H,4,6-7,22H2,1H3,(H,24,30)/t9-,10+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402810
PNG
(N-(3-cyano-1-methyl-1H- pyrazol-4-yl)-2-{[(1R,2S)-...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCC[C@@H]4O)nn23)c(n1)C#N
Show InChI InChI=1S/C18H20N8O2/c1-25-10-14(13(8-19)23-25)21-17(28)15-7-6-11-9-20-18(24-26(11)15)22-12-4-2-3-5-16(12)27/h6-7,9-10,12,16,27H,2-5H2,1H3,(H,21,28)(H,22,24)/t12-,16+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402745
PNG
(N-(2-cyanophenyl)-2- [(3R)-piperidin-3- ylamino]py...)
Show SMILES O=C(Nc1ccccc1C#N)c1ccc2cnc(N[C@@H]3CCCNC3)nn12
Show InChI InChI=1S/C19H19N7O/c20-10-13-4-1-2-6-16(13)24-18(27)17-8-7-15-12-22-19(25-26(15)17)23-14-5-3-9-21-11-14/h1-2,4,6-8,12,14,21H,3,5,9,11H2,(H,23,25)(H,24,27)/t14-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402763
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-[1-methyl...)
Show SMILES Cn1ncc(NC(=O)c2ccc3cnc(N[C@@H]4CCCC[C@@H]4N)nn23)c1C(F)(F)F
Show InChI InChI=1S/C18H21F3N8O/c1-28-15(18(19,20)21)13(9-24-28)25-16(30)14-7-6-10-8-23-17(27-29(10)14)26-12-5-3-2-4-11(12)22/h6-9,11-12H,2-5,22H2,1H3,(H,25,30)(H,26,27)/t11-,12+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402828
PNG
(2-[(3R)-3-aminopiperidin- 1-yl]-N-(2-cyanothiophen...)
Show SMILES N[C@@H]1CCCN(C1)c1ncc2ccc(C(=O)Nc3ccsc3C#N)n2n1
Show InChI InChI=1S/C17H17N7OS/c18-8-15-13(5-7-26-15)21-16(25)14-4-3-12-9-20-17(22-24(12)14)23-6-1-2-11(19)10-23/h3-5,7,9,11H,1-2,6,10,19H2,(H,21,25)/t11-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402766
PNG
(2-[(3S)- or (3R)-azepan-3- ylamino]-N-(2- cyanophe...)
Show SMILES O=C(Nc1ccccc1C#N)c1ccc2cnc(N[C@@H]3CCCCNC3)nn12
Show InChI InChI=1S/C20H21N7O/c21-11-14-5-1-2-7-17(14)25-19(28)18-9-8-16-13-23-20(26-27(16)18)24-15-6-3-4-10-22-12-15/h1-2,5,7-9,13,15,22H,3-4,6,10,12H2,(H,24,26)(H,25,28)/t15-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402795
PNG
(2-[(1S,5S)- or (1R,5R)-3,6- diazabicyclo[3.2.1]oct...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2C[C@H]3CN[C@H](C3)C2)c(n1)C(F)F
Show InChI InChI=1S/C18H20F2N8O/c1-26-9-13(15(24-26)16(19)20)23-17(29)14-3-2-12-6-22-18(25-28(12)14)27-7-10-4-11(8-27)21-5-10/h2-3,6,9-11,16,21H,4-5,7-8H2,1H3,(H,23,29)/t10-,11-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402775
PNG
(2-(3,8- diazabicyclo[3.2.1]oct-3- yl)-N-[1-methyl-...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2CC3CCC(C2)N3)c(n1)C(F)(F)F
Show InChI InChI=1S/C18H19F3N8O/c1-27-9-13(15(25-27)18(19,20)21)24-16(30)14-5-4-12-6-22-17(26-29(12)14)28-7-10-2-3-11(8-28)23-10/h4-6,9-11,23H,2-3,7-8H2,1H3,(H,24,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402855
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(1-methyl...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCC[C@@H]4N)nn23)cn1
Show InChI InChI=1S/C17H22N8O/c1-24-10-11(8-20-24)21-16(26)15-7-6-12-9-19-17(23-25(12)15)22-14-5-3-2-4-13(14)18/h6-10,13-14H,2-5,18H2,1H3,(H,21,26)(H,22,23)/t13-,14+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402856
PNG
(2-[(1S,4S)- or (1R,4R)- 2,5- diazabicyclo[2.2.2]oc...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2C[C@@H]3CC[C@H]2CN3)c(n1)C(F)(F)F
Show InChI InChI=1S/C18H19F3N8O/c1-27-9-13(15(25-27)18(19,20)21)24-16(30)14-5-4-12-7-23-17(26-29(12)14)28-8-10-2-3-11(28)6-22-10/h4-5,7,9-11,22H,2-3,6,8H2,1H3,(H,24,30)/t10-,11-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402760
PNG
(N-(3-bromo-1-methyl-1H- pyrazol-4-yl)-2-(1,4- diaz...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2CCCNCC2)c(Br)n1
Show InChI InChI=1S/C16H19BrN8O/c1-23-10-12(14(17)21-23)20-15(26)13-4-3-11-9-19-16(22-25(11)13)24-7-2-5-18-6-8-24/h3-4,9-10,18H,2,5-8H2,1H3,(H,20,26)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402805
PNG
(2-[(1S,5R)- or (1R,5S)-3,6- diazabicyclo[3.2.1]oct...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2C[C@H]3C[C@@H]2CNC3)c(n1)C(F)(F)F
Show InChI InChI=1S/C18H19F3N8O/c1-27-9-13(15(25-27)18(19,20)21)24-16(30)14-3-2-11-7-23-17(26-29(11)14)28-8-10-4-12(28)6-22-5-10/h2-3,7,9-10,12,22H,4-6,8H2,1H3,(H,24,30)/t10-,12+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402816
PNG
(2-{[(1S,2R)- or (1R,2S)-2- amino-4,4- difluorocycl...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@H]4CCC(F)(F)C[C@H]4N)nn23)c(n1)C(F)(F)F
Show InChI InChI=1S/C18H19F5N8O/c1-30-8-12(14(28-30)18(21,22)23)26-15(32)13-3-2-9-7-25-16(29-31(9)13)27-11-4-5-17(19,20)6-10(11)24/h2-3,7-8,10-11H,4-6,24H2,1H3,(H,26,32)(H,27,29)/t10-,11+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402785
PNG
(2-{[(1R,2R)-2-amino-3,3- difluorocyclohexyl]amino}...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCC(F)(F)[C@@H]4N)nn23)c(n1)C(F)F
Show InChI InChI=1S/C18H20F4N8O/c1-29-8-11(13(27-29)15(19)20)25-16(31)12-5-4-9-7-24-17(28-30(9)12)26-10-3-2-6-18(21,22)14(10)23/h4-5,7-8,10,14-15H,2-3,6,23H2,1H3,(H,25,31)(H,26,28)/t10-,14-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402841
PNG
(2-{[(3S,5R)-5- fluoropiperidin-3- yl]amino}-N-[1-m...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CNC[C@H](F)C4)nn23)c(n1)C(F)(F)F
Show InChI InChI=1S/C17H18F4N8O/c1-28-8-12(14(26-28)17(19,20)21)25-15(30)13-3-2-11-7-23-16(27-29(11)13)24-10-4-9(18)5-22-6-10/h2-3,7-10,22H,4-6H2,1H3,(H,24,27)(H,25,30)/t9-,10+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402781
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-[2- (trif...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc2ccc(C(=O)Nc3ccsc3C(F)(F)F)n2n1
Show InChI InChI=1S/C18H19F3N6OS/c19-18(20,21)15-13(7-8-29-15)24-16(28)14-6-5-10-9-23-17(26-27(10)14)25-12-4-2-1-3-11(12)22/h5-9,11-12H,1-4,22H2,(H,24,28)(H,25,26)/t11-,12+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402719
PNG
(N-(3-chloro-1-methyl-1H- pyrazol-4-yl)-2-(1,4- dia...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2CCCNCC2)c(Cl)n1
Show InChI InChI=1S/C16H19ClN8O/c1-23-10-12(14(17)21-23)20-15(26)13-4-3-11-9-19-16(22-25(11)13)24-7-2-5-18-6-8-24/h3-4,9-10,18H,2,5-8H2,1H3,(H,20,26)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402774
PNG
(2-[(1S,4S)- or (1R,4R)-2,5- diazabicyclo[2.2.2]oct...)
Show SMILES FC(F)c1cscc1NC(=O)c1ccc2cnc(nn12)N1C[C@H]2CC[C@@H]1CN2
Show InChI InChI=1S/C18H18F2N6OS/c19-16(20)13-8-28-9-14(13)23-17(27)15-4-3-12-6-22-18(24-26(12)15)25-7-10-1-2-11(25)5-21-10/h3-4,6,8-11,16,21H,1-2,5,7H2,(H,23,27)/t10-,11-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402792
PNG
(2-[(1S,5S)- or (1R,5R)-3,6- diazabicyclo[3.2.1]oct...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2C[C@@H]3CN[C@@H](C3)C2)c(n1)C(F)(F)F
Show InChI InChI=1S/C18H19F3N8O/c1-27-9-13(15(25-27)18(19,20)21)24-16(30)14-3-2-12-6-23-17(26-29(12)14)28-7-10-4-11(8-28)22-5-10/h2-3,6,9-11,22H,4-5,7-8H2,1H3,(H,24,30)/t10-,11-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402857
PNG
(2-[(1S,4S)- or (1R,4R)- 2,5- diazabicyclo[2.2.2]oc...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2C[C@H]3CC[C@@H]2CN3)c(n1)C(F)(F)F
Show InChI InChI=1S/C18H19F3N8O/c1-27-9-13(15(25-27)18(19,20)21)24-16(30)14-5-4-12-7-23-17(26-29(12)14)28-8-10-2-3-11(28)6-22-10/h4-5,7,9-11,22H,2-3,6,8H2,1H3,(H,24,30)/t10-,11-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402739
PNG
(N-(3-cyano-1-methyl-1H- pyrazol-4-yl)-2-[(1S,4S)- ...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2C[C@@H]3CC[C@H]2CN3)c(n1)C#N
Show InChI InChI=1S/C18H19N9O/c1-25-10-15(14(6-19)23-25)22-17(28)16-5-4-13-8-21-18(24-27(13)16)26-9-11-2-3-12(26)7-20-11/h4-5,8,10-12,20H,2-3,7,9H2,1H3,(H,22,28)/t11-,12-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402352
PNG
(N-[1-methyl-3- (trifluoromethyl)-1H- pyrazol-4-yl]...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2CCNCC2)c(n1)C(F)(F)F
Show InChI InChI=1S/C16H17F3N8O/c1-25-9-11(13(23-25)16(17,18)19)22-14(28)12-3-2-10-8-21-15(24-27(10)12)26-6-4-20-5-7-26/h2-3,8-9,20H,4-7H2,1H3,(H,22,28)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402738
PNG
(N-(3-chloro-1-methyl-1H- pyrazol-4-yl)-2-[(1S,4S)-...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2C[C@H]3CC[C@@H]2CN3)c(Cl)n1
Show InChI InChI=1S/C17H19ClN8O/c1-24-9-13(15(18)22-24)21-16(27)14-5-4-12-7-20-17(23-26(12)14)25-8-10-2-3-11(25)6-19-10/h4-5,7,9-11,19H,2-3,6,8H2,1H3,(H,21,27)/t10-,11-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402803
PNG
(N-(3-cyano-1-methyl-1H- pyrazol-4-yl)-2-[(1S,5S)- ...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2C[C@@H]3CN[C@@H](C3)C2)c(n1)C#N
Show InChI InChI=1S/C18H19N9O/c1-25-10-15(14(5-19)23-25)22-17(28)16-3-2-13-7-21-18(24-27(13)16)26-8-11-4-12(9-26)20-6-11/h2-3,7,10-12,20H,4,6,8-9H2,1H3,(H,22,28)/t11-,12-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402791
PNG
(2-{[(1R,2R)-2-amino-3,3- difluorocyclohexyl]amino}...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCC(F)(F)[C@@H]4N)nn23)c(n1)C#N
Show InChI InChI=1S/C18H19F2N9O/c1-28-9-13(12(7-21)26-28)24-16(30)14-5-4-10-8-23-17(27-29(10)14)25-11-3-2-6-18(19,20)15(11)22/h4-5,8-9,11,15H,2-3,6,22H2,1H3,(H,24,30)(H,25,27)/t11-,15-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402749
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-[2- (difl...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc2ccc(C(=O)Nc3ccccc3C(F)F)n2n1
Show InChI InChI=1S/C20H22F2N6O/c21-18(22)13-5-1-3-7-15(13)25-19(29)17-10-9-12-11-24-20(27-28(12)17)26-16-8-4-2-6-14(16)23/h1,3,5,7,9-11,14,16,18H,2,4,6,8,23H2,(H,25,29)(H,26,27)/t14-,16+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402734
PNG
(2-(1,4-diazepan-1-yl)-N-[4- (difluoromethyl)thioph...)
Show SMILES FC(F)c1cscc1NC(=O)c1ccc2cnc(nn12)N1CCCNCC1
Show InChI InChI=1S/C17H18F2N6OS/c18-15(19)12-9-27-10-13(12)22-16(26)14-3-2-11-8-21-17(23-25(11)14)24-6-1-4-20-5-7-24/h2-3,8-10,15,20H,1,4-7H2,(H,22,26)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402756
PNG
(N-(3-bromo-1-methyl-1H- pyrazol-4-yl)-2-[(1S,4S)- ...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2C[C@@H]3CC[C@H]2CN3)c(Br)n1
Show InChI InChI=1S/C17H19BrN8O/c1-24-9-13(15(18)22-24)21-16(27)14-5-4-12-7-20-17(23-26(12)14)25-8-10-2-3-11(25)6-19-10/h4-5,7,9-11,19H,2-3,6,8H2,1H3,(H,21,27)/t10-,11-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402463
PNG
(2-(1,4-diazepan-1-yl)-N- [1-methyl-3- (trifluorome...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2CCCNCC2)c(n1)C(F)(F)F
Show InChI InChI=1S/C17H19F3N8O/c1-26-10-12(14(24-26)17(18,19)20)23-15(29)13-4-3-11-9-22-16(25-28(11)13)27-7-2-5-21-6-8-27/h3-4,9-10,21H,2,5-8H2,1H3,(H,23,29)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402801
PNG
(N-(3-cyano-1-methyl-1H- pyrazol-4-yl)-2-(3,8- diaz...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2CC3CCC(C2)N3)c(n1)C#N
Show InChI InChI=1S/C18H19N9O/c1-25-10-15(14(6-19)23-25)22-17(28)16-5-4-13-7-20-18(24-27(13)16)26-8-11-2-3-12(9-26)21-11/h4-5,7,10-12,21H,2-3,8-9H2,1H3,(H,22,28)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402840
PNG
(2-{[(1R,2R)-2-amino-3,3- difluorocyclohexyl]amino}...)
Show SMILES N[C@@H]1[C@@H](CCCC1(F)F)Nc1ncc2ccc(C(=O)Nc3cscc3C#N)n2n1
Show InChI InChI=1S/C18H17F2N7OS/c19-18(20)5-1-2-12(15(18)22)25-17-23-7-11-3-4-14(27(11)26-17)16(28)24-13-9-29-8-10(13)6-21/h3-4,7-9,12,15H,1-2,5,22H2,(H,24,28)(H,25,26)/t12-,15-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402757
PNG
(N-(3-bromo-1-methyl-1H- pyrazol-4-yl)-2-[(1S,4S)- ...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2C[C@H]3CC[C@@H]2CN3)c(Br)n1
Show InChI InChI=1S/C17H19BrN8O/c1-24-9-13(15(18)22-24)21-16(27)14-5-4-12-7-20-17(23-26(12)14)25-8-10-2-3-11(25)6-19-10/h4-5,7,9-11,19H,2-3,6,8H2,1H3,(H,21,27)/t10-,11-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402737
PNG
(N-(3-chloro-1-methyl-1H- pyrazol-4-yl)-2-[(1S,4S)-...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2C[C@@H]3CC[C@H]2CN3)c(Cl)n1
Show InChI InChI=1S/C17H19ClN8O/c1-24-9-13(15(18)22-24)21-16(27)14-5-4-12-7-20-17(23-26(12)14)25-8-10-2-3-11(25)6-19-10/h4-5,7,9-11,19H,2-3,6,8H2,1H3,(H,21,27)/t10-,11-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402806
PNG
(2-[(1S,5R)- or (1R,5S)-3,6- diazabicyclo[3.2.1]oct...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2C[C@@H]3C[C@H]2CNC3)c(n1)C(F)(F)F
Show InChI InChI=1S/C18H19F3N8O/c1-27-9-13(15(25-27)18(19,20)21)24-16(30)14-3-2-11-7-23-17(26-29(11)14)28-8-10-4-12(28)6-22-5-10/h2-3,7,9-10,12,22H,4-6,8H2,1H3,(H,24,30)/t10-,12+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402744
PNG
(2-[(3R)-3-aminopiperidin- 1-yl]-N-(2- cyanophenyl)...)
Show SMILES N[C@@H]1CCCN(C1)c1ncc2ccc(C(=O)Nc3ccccc3C#N)n2n1
Show InChI InChI=1S/C19H19N7O/c20-10-13-4-1-2-6-16(13)23-18(27)17-8-7-15-11-22-19(24-26(15)17)25-9-3-5-14(21)12-25/h1-2,4,6-8,11,14H,3,5,9,12,21H2,(H,23,27)/t14-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402773
PNG
(2-[(1S,4S)- or (1R,4R)-2,5- diazabicyclo[2.2.2]oct...)
Show SMILES FC(F)c1cscc1NC(=O)c1ccc2cnc(nn12)N1C[C@@H]2CC[C@H]1CN2
Show InChI InChI=1S/C18H18F2N6OS/c19-16(20)13-8-28-9-14(13)23-17(27)15-4-3-12-6-22-18(24-26(12)15)25-7-10-1-2-11(25)5-21-10/h3-4,6,8-11,16,21H,1-2,5,7H2,(H,23,27)/t10-,11-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402821
PNG
(N-(3-cyano-1-methyl-1H- pyrazol-4-yl)-2-[(1R,5S)- ...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2C[C@@H]3C[C@H]2CNC3)c(n1)C#N
Show InChI InChI=1S/C18H19N9O/c1-25-10-15(14(5-19)23-25)22-17(28)16-3-2-12-8-21-18(24-27(12)16)26-9-11-4-13(26)7-20-6-11/h2-3,8,10-11,13,20H,4,6-7,9H2,1H3,(H,22,28)/t11-,13+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402853
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-[1-(2- hy...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc2ccc(C(=O)Nc3cnn(CCO)c3)n2n1
Show InChI InChI=1S/C18H24N8O2/c19-14-3-1-2-4-15(14)23-18-20-10-13-5-6-16(26(13)24-18)17(28)22-12-9-21-25(11-12)7-8-27/h5-6,9-11,14-15,27H,1-4,7-8,19H2,(H,22,28)(H,23,24)/t14-,15+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402799
PNG
(N-(4-chlorothiophen-3-yl)- 2-[(1S,4S)- or (1R,4R)-...)
Show SMILES Clc1cscc1NC(=O)c1ccc2cnc(nn12)N1C[C@H]2CC[C@@H]1CN2
Show InChI InChI=1S/C17H17ClN6OS/c18-13-8-26-9-14(13)21-16(25)15-4-3-12-6-20-17(22-24(12)15)23-7-10-1-2-11(23)5-19-10/h3-4,6,8-11,19H,1-2,5,7H2,(H,21,25)/t10-,11-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402761
PNG
(2-[(1S,4S)- or (1R,4R)-2,5- diazabicyclo[2.2.2]oct...)
Show SMILES FC(F)(F)c1ccccc1NC(=O)c1ccc2cnc(nn12)N1C[C@H]2CC[C@@H]1CN2
Show InChI InChI=1S/C20H19F3N6O/c21-20(22,23)15-3-1-2-4-16(15)26-18(30)17-8-7-14-10-25-19(27-29(14)17)28-11-12-5-6-13(28)9-24-12/h1-4,7-8,10,12-13,24H,5-6,9,11H2,(H,26,30)/t12-,13-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402732
PNG
(N-(2-chlorophenyl)-2-(1,4- diazepan-1-yl)pyrrolo[2...)
Show SMILES Clc1ccccc1NC(=O)c1ccc2cnc(nn12)N1CCCNCC1
Show InChI InChI=1S/C18H19ClN6O/c19-14-4-1-2-5-15(14)22-17(26)16-7-6-13-12-21-18(23-25(13)16)24-10-3-8-20-9-11-24/h1-2,4-7,12,20H,3,8-11H2,(H,22,26)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402772
PNG
(2-{[(1R,2R)-2-amino-3,3- difluorocyclohexyl]amino}...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCC(F)(F)[C@@H]4N)nn23)c(Cl)n1
Show InChI InChI=1S/C17H19ClF2N8O/c1-27-8-11(14(18)25-27)23-15(29)12-5-4-9-7-22-16(26-28(9)12)24-10-3-2-6-17(19,20)13(10)21/h4-5,7-8,10,13H,2-3,6,21H2,1H3,(H,23,29)(H,24,26)/t10-,13-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402740
PNG
(N-(3-cyano-1-methyl-1H- pyrazol-4-yl)-2-[(1S,4S)- ...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2C[C@H]3CC[C@@H]2CN3)c(n1)C#N
Show InChI InChI=1S/C18H19N9O/c1-25-10-15(14(6-19)23-25)22-17(28)16-5-4-13-8-21-18(24-27(13)16)26-9-11-2-3-12(26)7-20-11/h4-5,8,10-12,20H,2-3,7,9H2,1H3,(H,22,28)/t11-,12-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402511
PNG
(2-{[(1R,2R)-2-amino-3,3- difluorocyclohexyl]amino}...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCC(F)(F)[C@@H]4N)nn23)c(n1)C(F)(F)F
Show InChI InChI=1S/C18H19F5N8O/c1-30-8-11(14(28-30)18(21,22)23)26-15(32)12-5-4-9-7-25-16(29-31(9)12)27-10-3-2-6-17(19,20)13(10)24/h4-5,7-8,10,13H,2-3,6,24H2,1H3,(H,26,32)(H,27,29)/t10-,13-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402793
PNG
(2-[(1S,5S)- or (1R,5R)-3,6- diazabicyclo[3.2.1]oct...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2C[C@H]3CN[C@H](C3)C2)c(n1)C(F)(F)F
Show InChI InChI=1S/C18H19F3N8O/c1-27-9-13(15(25-27)18(19,20)21)24-16(30)14-3-2-12-6-23-17(26-29(12)14)28-7-10-4-11(8-28)22-5-10/h2-3,6,9-11,22H,4-5,7-8H2,1H3,(H,24,30)/t10-,11-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402786
PNG
(2-{[(1R,2R)-2-amino-3,3- difluorocyclohexyl]amino}...)
Show SMILES N[C@@H]1[C@@H](CCCC1(F)F)Nc1ncc2ccc(C(=O)Nc3cscc3C(F)F)n2n1
Show InChI InChI=1S/C18H18F4N6OS/c19-15(20)10-7-30-8-12(10)25-16(29)13-4-3-9-6-24-17(27-28(9)13)26-11-2-1-5-18(21,22)14(11)23/h3-4,6-8,11,14-15H,1-2,5,23H2,(H,25,29)(H,26,27)/t11-,14-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402854
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-[1-(2- me...)
Show SMILES COCCn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCC[C@@H]4N)nn23)cn1
Show InChI InChI=1S/C19H26N8O2/c1-29-9-8-26-12-13(10-22-26)23-18(28)17-7-6-14-11-21-19(25-27(14)17)24-16-5-3-2-4-15(16)20/h6-7,10-12,15-16H,2-5,8-9,20H2,1H3,(H,23,28)(H,24,25)/t15-,16+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402350
PNG
(2-{[(1R,2S)-2- hydroxycyclohexyl]amino}- N-[1-meth...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCC[C@@H]4O)nn23)c(n1)C(F)(F)F
Show InChI InChI=1S/C18H20F3N7O2/c1-27-9-12(15(25-27)18(19,20)21)23-16(30)13-7-6-10-8-22-17(26-28(10)13)24-11-4-2-3-5-14(11)29/h6-9,11,14,29H,2-5H2,1H3,(H,23,30)(H,24,26)/t11-,14+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402727
PNG
(N-(3-cyano-1-methyl-1H- pyrazol-4-yl)-2-(1,4- diaz...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2CCCNCC2)c(n1)C#N
Show InChI InChI=1S/C17H19N9O/c1-24-11-14(13(9-18)22-24)21-16(27)15-4-3-12-10-20-17(23-26(12)15)25-7-2-5-19-6-8-25/h3-4,10-11,19H,2,5-8H2,1H3,(H,21,27)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402575
PNG
(N-(4-cyanothiophen-3-yl)- 2-(1,4-diazepan-1- yl)py...)
Show SMILES O=C(Nc1cscc1C#N)c1ccc2cnc(nn12)N1CCCNCC1
Show InChI InChI=1S/C17H17N7OS/c18-8-12-10-26-11-14(12)21-16(25)15-3-2-13-9-20-17(22-24(13)15)23-6-1-4-19-5-7-23/h2-3,9-11,19H,1,4-7H2,(H,21,25)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402798
PNG
(N-(4-chlorothiophen-3-yl)- 2-[(1S,4S)- or (1R,4R)-...)
Show SMILES Clc1cscc1NC(=O)c1ccc2cnc(nn12)N1C[C@@H]2CC[C@H]1CN2
Show InChI InChI=1S/C17H17ClN6OS/c18-13-8-26-9-14(13)21-16(25)15-4-3-12-6-20-17(22-24(12)15)23-7-10-1-2-11(23)5-19-10/h3-4,6,8-11,19H,1-2,5,7H2,(H,21,25)/t10-,11-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402782
PNG
(2-{[(1R,2R)-2-amino-3,3- difluorocyclohexyl]amino}...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCC(F)(F)[C@@H]4N)nn23)c(Br)n1
Show InChI InChI=1S/C17H19BrF2N8O/c1-27-8-11(14(18)25-27)23-15(29)12-5-4-9-7-22-16(26-28(9)12)24-10-3-2-6-17(19,20)13(10)21/h4-5,7-8,10,13H,2-3,6,21H2,1H3,(H,23,29)(H,24,26)/t10-,13-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402804
PNG
(N-(3-cyano-1-methyl-1H- pyrazol-4-yl)-2-[(1S,5S)- ...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2C[C@H]3CN[C@H](C3)C2)c(n1)C#N
Show InChI InChI=1S/C18H19N9O/c1-25-10-15(14(5-19)23-25)22-17(28)16-3-2-13-7-21-18(24-27(13)16)26-8-11-4-12(9-26)20-6-11/h2-3,7,10-12,20H,4,6,8-9H2,1H3,(H,22,28)/t11-,12-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402720
PNG
(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-[2- (trif...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc2ccc(C(=O)Nc3ccccc3C(F)(F)F)n2n1
Show InChI InChI=1S/C20H21F3N6O/c21-20(22,23)13-5-1-3-7-15(13)26-18(30)17-10-9-12-11-25-19(28-29(12)17)27-16-8-4-2-6-14(16)24/h1,3,5,7,9-11,14,16H,2,4,6,8,24H2,(H,26,30)(H,27,28)/t14-,16+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402834
PNG
(N-(2-cyanothiophen-3-yl)- 2-{[(1R,2S)-2- hydroxycy...)
Show SMILES O[C@H]1CCCC[C@H]1Nc1ncc2ccc(C(=O)Nc3ccsc3C#N)n2n1
Show InChI InChI=1S/C18H18N6O2S/c19-9-16-13(7-8-27-16)21-17(26)14-6-5-11-10-20-18(23-24(11)14)22-12-3-1-2-4-15(12)25/h5-8,10,12,15,25H,1-4H2,(H,21,26)(H,22,23)/t12-,15+/m1/s1
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US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402700
PNG
(N-(2-cyanothiophen-3-yl)- 2-(2,5- diazabicyclo[2.2...)
Show SMILES O=C(Nc1ccsc1C#N)c1ccc2cnc(nn12)N1CC2CCC1CN2
Show InChI InChI=1S/C18H17N7OS/c19-7-16-14(5-6-27-16)22-17(26)15-4-3-13-9-21-18(23-25(13)15)24-10-11-1-2-12(24)8-20-11/h3-6,9,11-12,20H,1-2,8,10H2,(H,22,26)
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n/an/a 399n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402729
PNG
(N-(4-cyanothiophen-3-yl)- 2-(2,5- diazabicyclo[2.2...)
Show SMILES O=C(Nc1cscc1C#N)c1ccc2cnc(nn12)N1CC2CCC1CN2
Show InChI InChI=1S/C18H17N7OS/c19-5-11-9-27-10-15(11)22-17(26)16-4-3-14-7-21-18(23-25(14)16)24-8-12-1-2-13(24)6-20-12/h3-4,7,9-10,12-13,20H,1-2,6,8H2,(H,22,26)
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n/an/a 426n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402748
PNG
(N-(2-chlorophenyl)-2- [(1S,4S)- or (1R,4R)-2,5- di...)
Show SMILES Clc1ccccc1NC(=O)c1ccc2cnc(nn12)N1C[C@H]2CC[C@@H]1CN2
Show InChI InChI=1S/C19H19ClN6O/c20-15-3-1-2-4-16(15)23-18(27)17-8-7-14-10-22-19(24-26(14)17)25-11-12-5-6-13(25)9-21-12/h1-4,7-8,10,12-13,21H,5-6,9,11H2,(H,23,27)/t12-,13-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402820
PNG
(2-{[(1S,2R)- or (1R,2S)-2- amino-4,4- difluorocycl...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCC(F)(F)C[C@@H]4N)nn23)c(n1)C(F)(F)F
Show InChI InChI=1S/C18H19F5N8O/c1-30-8-12(14(28-30)18(21,22)23)26-15(32)13-3-2-9-7-25-16(29-31(9)13)27-11-4-5-17(19,20)6-10(11)24/h2-3,7-8,10-11H,4-6,24H2,1H3,(H,26,32)(H,27,29)/t10-,11+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402764
PNG
(N-(2-cyanophenyl)-2- {[(1R,2S)-2- hydroxycyclohexy...)
Show SMILES O[C@H]1CCCC[C@H]1Nc1ncc2ccc(C(=O)Nc3ccccc3C#N)n2n1
Show InChI InChI=1S/C20H20N6O2/c21-11-13-5-1-2-6-15(13)23-19(28)17-10-9-14-12-22-20(25-26(14)17)24-16-7-3-4-8-18(16)27/h1-2,5-6,9-10,12,16,18,27H,3-4,7-8H2,(H,23,28)(H,24,25)/t16-,18+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402818
PNG
(2-{[(1S,2R)- or (1R,2S)-2- amino-5,5- difluorocycl...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@H]4CC(F)(F)CC[C@H]4N)nn23)c(n1)C(F)F
Show InChI InChI=1S/C18H20F4N8O/c1-29-8-12(14(27-29)15(19)20)25-16(31)13-3-2-9-7-24-17(28-30(9)13)26-11-6-18(21,22)5-4-10(11)23/h2-3,7-8,10-11,15H,4-6,23H2,1H3,(H,25,31)(H,26,28)/t10-,11+/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402713
PNG
(N-(4-bromothiophen-3- yl)-2-(2,5- diazabicyclo[2.2...)
Show SMILES Brc1cscc1NC(=O)c1ccc2cnc(nn12)N1CC2CCC1CN2
Show InChI InChI=1S/C17H17BrN6OS/c18-13-8-26-9-14(13)21-16(25)15-4-3-12-6-20-17(22-24(12)15)23-7-10-1-2-11(23)5-19-10/h3-4,6,8-11,19H,1-2,5,7H2,(H,21,25)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402747
PNG
(N-(2-chlorothiophen-3-yl)- 2-[(1S,4S)- or (1R,4R)-...)
Show SMILES Clc1sccc1NC(=O)c1ccc2cnc(nn12)N1C[C@H]2CC[C@@H]1CN2
Show InChI InChI=1S/C17H17ClN6OS/c18-15-13(5-6-26-15)21-16(25)14-4-3-12-8-20-17(22-24(12)14)23-9-10-1-2-11(23)7-19-10/h3-6,8,10-11,19H,1-2,7,9H2,(H,21,25)/t10-,11-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402767
PNG
(N-(2-cyanophenyl)-2- [(1S,4S)- or (1R,4R)-2,5- dia...)
Show SMILES O=C(Nc1ccccc1C#N)c1ccc2cnc(nn12)N1C[C@@H]2CC[C@H]1CN2
Show InChI InChI=1S/C20H19N7O/c21-9-13-3-1-2-4-17(13)24-19(28)18-8-7-16-11-23-20(25-27(16)18)26-12-14-5-6-15(26)10-22-14/h1-4,7-8,11,14-15,22H,5-6,10,12H2,(H,24,28)/t14-,15-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402823
PNG
(2-{[(1R,2R)-2-amino-3,3- difluorocyclohexyl]amino}...)
Show SMILES N[C@@H]1[C@@H](CCCC1(F)F)Nc1ncc2ccc(C(=O)Nc3ccccc3C#N)n2n1
Show InChI InChI=1S/C20H19F2N7O/c21-20(22)9-3-6-15(17(20)24)27-19-25-11-13-7-8-16(29(13)28-19)18(30)26-14-5-2-1-4-12(14)10-23/h1-2,4-5,7-8,11,15,17H,3,6,9,24H2,(H,26,30)(H,27,28)/t15-,17-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402724
PNG
(N-(2-chlorothiophen-3-yl)- 2-(1,4-diazepan-1- yl)p...)
Show SMILES Clc1sccc1NC(=O)c1ccc2cnc(nn12)N1CCCNCC1
Show InChI InChI=1S/C16H17ClN6OS/c17-14-12(4-9-25-14)20-15(24)13-3-2-11-10-19-16(21-23(11)13)22-7-1-5-18-6-8-22/h2-4,9-10,18H,1,5-8H2,(H,20,24)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402822
PNG
(N-(3-cyano-1-methyl-1H- pyrazol-4-yl)-2-[(1R,5S)- ...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2C[C@H]3C[C@@H]2CNC3)c(n1)C#N
Show InChI InChI=1S/C18H19N9O/c1-25-10-15(14(5-19)23-25)22-17(28)16-3-2-12-8-21-18(24-27(12)16)26-9-11-4-13(26)7-20-6-11/h2-3,8,10-11,13,20H,4,6-7,9H2,1H3,(H,22,28)/t11-,13+/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402755
PNG
(2-[(1S,4S)- or (1R,4R)-2,5- diazabicyclo[2.2.2]oct...)
Show SMILES FC(F)c1ccccc1NC(=O)c1ccc2cnc(nn12)N1C[C@H]2CC[C@@H]1CN2
Show InChI InChI=1S/C20H20F2N6O/c21-18(22)15-3-1-2-4-16(15)25-19(29)17-8-7-14-10-24-20(26-28(14)17)27-11-12-5-6-13(27)9-23-12/h1-4,7-8,10,12-13,18,23H,5-6,9,11H2,(H,25,29)/t12-,13-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402769
PNG
(N-(2-cyanophenyl)-2-(5,8- diazaspiro[2.6]non-5- yl...)
Show SMILES O=C(Nc1ccccc1C#N)c1ccc2cnc(nn12)N1CCNCC2(CC2)C1
Show InChI InChI=1S/C21H21N7O/c22-11-15-3-1-2-4-17(15)25-19(29)18-6-5-16-12-24-20(26-28(16)18)27-10-9-23-13-21(14-27)7-8-21/h1-6,12,23H,7-10,13-14H2,(H,25,29)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402845
PNG
(2-{[(1R,2R)-2-amino-3,3- difluorocyclohexyl]amino}...)
Show SMILES N[C@@H]1[C@@H](CCCC1(F)F)Nc1ncc2ccc(C(=O)Nc3ccsc3C#N)n2n1
Show InChI InChI=1S/C18H17F2N7OS/c19-18(20)6-1-2-12(15(18)22)25-17-23-9-10-3-4-13(27(10)26-17)16(28)24-11-5-7-29-14(11)8-21/h3-5,7,9,12,15H,1-2,6,22H2,(H,24,28)(H,25,26)/t12-,15-/m1/s1
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n/an/a 1.04E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402736
PNG
(N-(2-cyanothiophen-3-yl)- 2-(1,4-diazepan-1- yl)py...)
Show SMILES O=C(Nc1ccsc1C#N)c1ccc2cnc(nn12)N1CCCNCC1
Show InChI InChI=1S/C17H17N7OS/c18-10-15-13(4-9-26-15)21-16(25)14-3-2-12-11-20-17(22-24(12)14)23-7-1-5-19-6-8-23/h2-4,9,11,19H,1,5-8H2,(H,21,25)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402814
PNG
(2-{[(1R,2R)-2-amino-3,3- difluorocyclohexyl]amino}...)
Show SMILES N[C@@H]1[C@@H](CCCC1(F)F)Nc1ncc2ccc(C(=O)Nc3cscc3Cl)n2n1
Show InChI InChI=1S/C17H17ClF2N6OS/c18-10-7-28-8-12(10)23-15(27)13-4-3-9-6-22-16(25-26(9)13)24-11-2-1-5-17(19,20)14(11)21/h3-4,6-8,11,14H,1-2,5,21H2,(H,23,27)(H,24,25)/t11-,14-/m1/s1
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n/an/a 1.27E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402780
PNG
(2-[(1S,4S)- or (1R,4R)-2,5- diazabicyclo[2.2.2]oct...)
Show SMILES FC(F)(F)c1sccc1NC(=O)c1ccc2cnc(nn12)N1C[C@H]2CC[C@@H]1CN2
Show InChI InChI=1S/C18H17F3N6OS/c19-18(20,21)15-13(5-6-29-15)24-16(28)14-4-3-12-8-23-17(25-27(12)14)26-9-10-1-2-11(26)7-22-10/h3-6,8,10-11,22H,1-2,7,9H2,(H,24,28)/t10-,11-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402771
PNG
(2-[(1S,4S)- or (1R,4R)-2,5- diazabicyclo[2.2.2]oct...)
Show SMILES FC(F)(F)c1ccccc1NC(=O)c1ccc2cnc(nn12)N1C[C@@H]2CC[C@H]1CN2
Show InChI InChI=1S/C20H19F3N6O/c21-20(22,23)15-3-1-2-4-16(15)26-18(30)17-8-7-14-10-25-19(27-29(14)17)28-11-12-5-6-13(28)9-24-12/h1-4,7-8,10,12-13,24H,5-6,9,11H2,(H,26,30)/t12-,13-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402829
PNG
(N-(4-cyanothiophen-3-yl)- 2-{[(1R,2S)-2- hydroxycy...)
Show SMILES O[C@H]1CCCC[C@H]1Nc1ncc2ccc(C(=O)Nc3cscc3C#N)n2n1
Show InChI InChI=1S/C18H18N6O2S/c19-7-11-9-27-10-14(11)21-17(26)15-6-5-12-8-20-18(23-24(12)15)22-13-3-1-2-4-16(13)25/h5-6,8-10,13,16,25H,1-4H2,(H,21,26)(H,22,23)/t13-,16+/m1/s1
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n/an/a 1.59E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402825
PNG
(2-{[(1R,2R)-2-amino-3,3- difluorocyclohexyl]amino}...)
Show SMILES N[C@@H]1[C@@H](CCCC1(F)F)Nc1ncc2ccc(C(=O)Nc3ccccc3Cl)n2n1
Show InChI InChI=1S/C19H19ClF2N6O/c20-12-4-1-2-5-13(12)25-17(29)15-8-7-11-10-24-18(27-28(11)15)26-14-6-3-9-19(21,22)16(14)23/h1-2,4-5,7-8,10,14,16H,3,6,9,23H2,(H,25,29)(H,26,27)/t14-,16-/m1/s1
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n/an/a 1.64E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402746
PNG
(N-(2-chlorothiophen-3-yl)- 2-[(1S,4S)- or (1R,4R)-...)
Show SMILES Clc1sccc1NC(=O)c1ccc2cnc(nn12)N1C[C@@H]2CC[C@H]1CN2
Show InChI InChI=1S/C17H17ClN6OS/c18-15-13(5-6-26-15)21-16(25)14-4-3-12-8-20-17(22-24(12)14)23-9-10-1-2-11(23)7-19-10/h3-6,8,10-11,19H,1-2,7,9H2,(H,21,25)/t10-,11-/m0/s1
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n/an/a 1.64E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402741
PNG
(N-(2-bromothiophen-3- yl)-2-[(1S,4S)- or (1R,4R)- ...)
Show SMILES Brc1sccc1NC(=O)c1ccc2cnc(nn12)N1C[C@@H]2CC[C@H]1CN2
Show InChI InChI=1S/C17H17BrN6OS/c18-15-13(5-6-26-15)21-16(25)14-4-3-12-8-20-17(22-24(12)14)23-9-10-1-2-11(23)7-19-10/h3-6,8,10-11,19H,1-2,7,9H2,(H,21,25)/t10-,11-/m0/s1
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n/an/a 1.65E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402730
PNG
(N-(2-bromothiophen-3- yl)-2-(1,4-diazepan-1- yl)py...)
Show SMILES Brc1sccc1NC(=O)c1ccc2cnc(nn12)N1CCCNCC1
Show InChI InChI=1S/C16H17BrN6OS/c17-14-12(4-9-25-14)20-15(24)13-3-2-11-10-19-16(21-23(11)13)22-7-1-5-18-6-8-22/h2-4,9-10,18H,1,5-8H2,(H,20,24)
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n/an/a 1.67E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402703
PNG
(N-(4-bromothiophen-3- yl)-2-(1,4-diazepan-1- yl)py...)
Show SMILES Brc1cscc1NC(=O)c1ccc2cnc(nn12)N1CCCNCC1
Show InChI InChI=1S/C16H17BrN6OS/c17-12-9-25-10-13(12)20-15(24)14-3-2-11-8-19-16(21-23(11)14)22-6-1-4-18-5-7-22/h2-3,8-10,18H,1,4-7H2,(H,20,24)
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n/an/a 1.68E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402751
PNG
(N-(2-cyanophenyl)-2- piperazin-1-ylpyrrolo[2,1- f]...)
Show SMILES O=C(Nc1ccccc1C#N)c1ccc2cnc(nn12)N1CCNCC1
Show InChI InChI=1S/C18H17N7O/c19-11-13-3-1-2-4-15(13)22-17(26)16-6-5-14-12-21-18(23-25(14)16)24-9-7-20-8-10-24/h1-6,12,20H,7-10H2,(H,22,26)
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n/an/a 1.91E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402790
PNG
(2-{[(1R,2R)-2-amino-3,3- difluorocyclohexyl]amino}...)
Show SMILES N[C@@H]1[C@@H](CCCC1(F)F)Nc1ncc2ccc(C(=O)Nc3ccsc3Cl)n2n1
Show InChI InChI=1S/C17H17ClF2N6OS/c18-14-11(5-7-28-14)23-15(27)12-4-3-9-8-22-16(25-26(9)12)24-10-2-1-6-17(19,20)13(10)21/h3-5,7-8,10,13H,1-2,6,21H2,(H,23,27)(H,24,25)/t10-,13-/m1/s1
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n/an/a 1.91E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402742
PNG
(N-(2-bromothiophen-3- yl)-2-[(1S,4S)- or (1R,4R)- ...)
Show SMILES Brc1sccc1NC(=O)c1ccc2cnc(nn12)N1C[C@H]2CC[C@@H]1CN2
Show InChI InChI=1S/C17H17BrN6OS/c18-15-13(5-6-26-15)21-16(25)14-4-3-12-8-20-17(22-24(12)14)23-9-10-1-2-11(23)7-19-10/h3-6,8,10-11,19H,1-2,7,9H2,(H,21,25)/t10-,11-/m1/s1
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n/an/a 1.93E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402770
PNG
(N-(2-bromophenyl)-2- [(1S,4S)- or (1R,4R)-2,5- dia...)
Show SMILES Brc1ccccc1NC(=O)c1ccc2cnc(nn12)N1C[C@H]2CC[C@@H]1CN2
Show InChI InChI=1S/C19H19BrN6O/c20-15-3-1-2-4-16(15)23-18(27)17-8-7-14-10-22-19(24-26(14)17)25-11-12-5-6-13(25)9-21-12/h1-4,7-8,10,12-13,21H,5-6,9,11H2,(H,23,27)/t12-,13-/m1/s1
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n/an/a 1.96E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402758
PNG
(N-(2-chlorophenyl)-2- [(1S,4S)- or (1R,4R)-2,5- di...)
Show SMILES Clc1ccccc1NC(=O)c1ccc2cnc(nn12)N1C[C@@H]2CC[C@H]1CN2
Show InChI InChI=1S/C19H19ClN6O/c20-15-3-1-2-4-16(15)23-18(27)17-8-7-14-10-22-19(24-26(14)17)25-11-12-5-6-13(25)9-21-12/h1-4,7-8,10,12-13,21H,5-6,9,11H2,(H,23,27)/t12-,13-/m0/s1
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n/an/a 2.06E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402824
PNG
(2-{[(1R,2R)-2-amino-3,3- difluorocyclohexyl]amino}...)
Show SMILES N[C@@H]1[C@@H](CCCC1(F)F)Nc1ncc2ccc(C(=O)Nc3ccccc3C(F)(F)F)n2n1
Show InChI InChI=1S/C20H19F5N6O/c21-19(22)9-3-6-14(16(19)26)29-18-27-10-11-7-8-15(31(11)30-18)17(32)28-13-5-2-1-4-12(13)20(23,24)25/h1-2,4-5,7-8,10,14,16H,3,6,9,26H2,(H,28,32)(H,29,30)/t14-,16-/m1/s1
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n/an/a 2.19E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402779
PNG
(2-[(1S,4S)- or (1R,4R)-2,5- diazabicyclo[2.2.2]oct...)
Show SMILES FC(F)(F)c1sccc1NC(=O)c1ccc2cnc(nn12)N1C[C@@H]2CC[C@H]1CN2
Show InChI InChI=1S/C18H17F3N6OS/c19-18(20,21)15-13(5-6-29-15)24-16(28)14-4-3-12-8-23-17(25-27(12)14)26-9-10-1-2-11(26)7-22-10/h3-6,8,10-11,22H,1-2,7,9H2,(H,24,28)/t10-,11-/m0/s1
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n/an/a 2.27E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402778
PNG
(2-(1,4-diazepan-1-yl)-N- [2- (trifluoromethyl)thio...)
Show SMILES FC(F)(F)c1sccc1NC(=O)c1ccc2cnc(nn12)N1CCCNCC1
Show InChI InChI=1S/C17H17F3N6OS/c18-17(19,20)14-12(4-9-28-14)23-15(27)13-3-2-11-10-22-16(24-26(11)13)25-7-1-5-21-6-8-25/h2-4,9-10,21H,1,5-8H2,(H,23,27)
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n/an/a 2.64E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402817
PNG
(2-{[(1S,2R)- or (1R,2S)-2- amino-4,4- difluorocycl...)
Show SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@H]4CCC(F)(F)C[C@H]4N)nn23)c(n1)C(F)F
Show InChI InChI=1S/C18H20F4N8O/c1-29-8-12(14(27-29)15(19)20)25-16(31)13-3-2-9-7-24-17(28-30(9)13)26-11-4-5-18(21,22)6-10(11)23/h2-3,7-8,10-11,15H,4-6,23H2,1H3,(H,25,31)(H,26,28)/t10-,11+/m1/s1
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n/an/a 3.65E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402721
PNG
(2-(1,4-diazepan-1-yl)-N- [2- (trifluoromethyl)phen...)
Show SMILES FC(F)(F)c1ccccc1NC(=O)c1ccc2cnc(nn12)N1CCCNCC1
Show InChI InChI=1S/C19H19F3N6O/c20-19(21,22)14-4-1-2-5-15(14)25-17(29)16-7-6-13-12-24-18(26-28(13)16)27-10-3-8-23-9-11-27/h1-2,4-7,12,23H,3,8-11H2,(H,25,29)
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n/an/a 3.98E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402768
PNG
(N-(2-cyanophenyl)-2- [(1S,4S)- or (1R,4R)-2,5- dia...)
Show SMILES O=C(Nc1ccccc1C#N)c1ccc2cnc(nn12)N1C[C@H]2CC[C@@H]1CN2
Show InChI InChI=1S/C20H19N7O/c21-9-13-3-1-2-4-17(13)24-19(28)18-8-7-16-11-23-20(25-27(16)18)26-12-14-5-6-15(26)10-22-14/h1-4,7-8,11,14-15,22H,5-6,10,12H2,(H,24,28)/t14-,15-/m1/s1
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n/an/a 4.00E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402787
PNG
(2-{[(1R,2R)-2-amino-3,3- difluorocyclohexyl]amino}...)
Show SMILES N[C@@H]1[C@@H](CCCC1(F)F)Nc1ncc2ccc(C(=O)Nc3ccsc3Br)n2n1
Show InChI InChI=1S/C17H17BrF2N6OS/c18-14-11(5-7-28-14)23-15(27)12-4-3-9-8-22-16(25-26(9)12)24-10-2-1-6-17(19,20)13(10)21/h3-5,7-8,10,13H,1-2,6,21H2,(H,23,27)(H,24,25)/t10-,13-/m1/s1
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n/an/a 4.15E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402752
PNG
(N-(2-cyanophenyl)-2-(1,4- diazepan-1-yl)pyrrolo[2,...)
Show SMILES O=C(Nc1ccccc1C#N)c1ccc2cnc(nn12)N1CCCNCC1
Show InChI InChI=1S/C19H19N7O/c20-12-14-4-1-2-5-16(14)23-18(27)17-7-6-15-13-22-19(24-26(15)17)25-10-3-8-21-9-11-25/h1-2,4-7,13,21H,3,8-11H2,(H,23,27)
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n/an/a 4.27E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402788
PNG
(2-{[(1R,2R)-2-amino-3,3- difluorocyclohexyl]amino}...)
Show SMILES N[C@@H]1[C@@H](CCCC1(F)F)Nc1ncc2ccc(C(=O)Nc3ccsc3C(F)(F)F)n2n1
Show InChI InChI=1S/C18H17F5N6OS/c19-17(20)6-1-2-10(13(17)24)27-16-25-8-9-3-4-12(29(9)28-16)15(30)26-11-5-7-31-14(11)18(21,22)23/h3-5,7-8,10,13H,1-2,6,24H2,(H,26,30)(H,27,28)/t10-,13-/m1/s1
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n/an/a 4.70E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402796
PNG
(N-(4-chlorothiophen-3-yl)- 2-(1,4-diazepan-1- yl)p...)
Show SMILES Clc1cscc1NC(=O)c1ccc2cnc(nn12)N1CCCNCC1
Show InChI InChI=1S/C16H17ClN6OS/c17-12-9-25-10-13(12)20-15(24)14-3-2-11-8-19-16(21-23(11)14)22-6-1-4-18-5-7-22/h2-3,8-10,18H,1,4-7H2,(H,20,24)
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n/an/a 4.82E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402726
PNG
(N-(2-bromophenyl)-2- (1,4-diazepan-1- yl)pyrrolo[2...)
Show SMILES Brc1ccccc1NC(=O)c1ccc2cnc(nn12)N1CCCNCC1
Show InChI InChI=1S/C18H19BrN6O/c19-14-4-1-2-5-15(14)22-17(26)16-7-6-13-12-21-18(23-25(13)16)24-10-3-8-20-9-11-24/h1-2,4-7,12,20H,3,8-11H2,(H,22,26)
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US Patent
n/an/a 5.35E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402797
PNG
(2-{[(1R,2R)-2-amino-3,3- difluorocyclohexyl]amino}...)
Show SMILES N[C@@H]1[C@@H](CCCC1(F)F)Nc1ncc2ccc(C(=O)Nc3ccccc3Br)n2n1
Show InChI InChI=1S/C19H19BrF2N6O/c20-12-4-1-2-5-13(12)25-17(29)15-8-7-11-10-24-18(27-28(11)15)26-14-6-3-9-19(21,22)16(14)23/h1-2,4-5,7-8,10,14,16H,3,6,9,23H2,(H,25,29)(H,26,27)/t14-,16-/m1/s1
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n/an/a 5.81E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402750
PNG
(2-(1,4-diazepan-1-yl)-N- [2- (difluoromethyl)pheny...)
Show SMILES FC(F)c1ccccc1NC(=O)c1ccc2cnc(nn12)N1CCCNCC1
Show InChI InChI=1S/C19H20F2N6O/c20-17(21)14-4-1-2-5-15(14)24-18(28)16-7-6-13-12-23-19(25-27(13)16)26-10-3-8-22-9-11-26/h1-2,4-7,12,17,22H,3,8-11H2,(H,24,28)
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n/an/a 6.57E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402777
PNG
(N-(2-bromophenyl)-2- [(1S,4S)- or (1R,4R)-2,5- dia...)
Show SMILES Brc1ccccc1NC(=O)c1ccc2cnc(nn12)N1C[C@@H]2CC[C@H]1CN2
Show InChI InChI=1S/C19H19BrN6O/c20-15-3-1-2-4-16(15)23-18(27)17-8-7-14-10-22-19(24-26(14)17)25-11-12-5-6-13(25)9-21-12/h1-4,7-8,10,12-13,21H,5-6,9,11H2,(H,23,27)/t12-,13-/m0/s1
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n/an/a 7.81E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM402754
PNG
(2-[(1S,4S)- or (1R,4R)-2,5- diazabicyclo[2.2.2]oct...)
Show SMILES FC(F)c1ccccc1NC(=O)c1ccc2cnc(nn12)N1C[C@@H]2CC[C@H]1CN2
Show InChI InChI=1S/C20H20F2N6O/c21-18(22)15-3-1-2-4-16(15)25-19(29)17-8-7-14-10-24-20(26-28(14)17)27-11-12-5-6-13(27)9-23-12/h1-4,7-8,10,12-13,18,23H,5-6,9,11H2,(H,25,29)/t12-,13-/m0/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US10329295 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%