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Patent code US10329299

Compile Data Set for Download or QSAR

Found 436 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342482
PNG
(US10329299, Compound 50 | US9775844, Compound 50)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1nc2cccc(C#C)c2c(=O)n1-c1ccc(F)cc1
Show InChI InChI=1/C25H18FN7O2/c1-3-15-6-4-7-18-19(15)25(35)33(17-10-8-16(26)9-11-17)22(30-18)14(2)29-24(34)20-21(27)31-32-13-5-12-28-23(20)32/h1,4-14H,2H3,(H2,27,31)(H,29,34)/t14-/s2
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n/an/a 2.00E+3n/an/an/an/an/an/a



Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50192885
PNG
(CHEMBL3923629 | US10329299, Compound 54 | US977584...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cscn3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C29H21N7O2S/c1-18(33-28(37)25-26(30)34-35-14-6-13-31-27(25)35)23-15-20-8-5-7-19(11-12-21-16-39-17-32-21)24(20)29(38)36(23)22-9-3-2-4-10-22/h2-10,13-18H,1H3,(H2,30,34)(H,33,37)/t18-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM342489
PNG
(US10329299, Compound 56 | US9775844, Compound 56)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#CCN3CCN(C)CC3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C32H32N8O2/c1-22(35-31(41)28-29(33)36-39-16-8-14-34-30(28)39)26-21-24-10-6-9-23(11-7-15-38-19-17-37(2)18-20-38)27(24)32(42)40(26)25-12-4-3-5-13-25/h3-6,8-10,12-14,16,21-22H,15,17-20H2,1-2H3,(H2,33,36)(H,35,41)/t22-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342494
PNG
(US10329299, Compound 60 | US9775844, Compound 60)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3nc(C)cs3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C30H23N7O2S/c1-18-17-40-24(33-18)13-12-20-8-6-9-21-16-23(37(30(39)25(20)21)22-10-4-3-5-11-22)19(2)34-29(38)26-27(31)35-36-15-7-14-32-28(26)36/h3-11,14-17,19H,1-2H3,(H2,31,35)(H,34,38)/t19-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342496
PNG
(US10329299, Compound 62 | US9775844, Compound 62)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#CC3(O)CN4CCC3CC4)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C33H31N7O3/c1-21(36-31(41)28-29(34)37-39-16-6-15-35-30(28)39)26-19-23-8-5-7-22(11-14-33(43)20-38-17-12-24(33)13-18-38)27(23)32(42)40(26)25-9-3-2-4-10-25/h2-10,15-16,19,21,24,43H,12-13,17-18,20H2,1H3,(H2,34,37)(H,36,41)/t21-,33?/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342471
PNG
(US10329299, Compound 63 | US9775844, Compound 40)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3csc(C)n3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C30H23N7O2S/c1-18(33-29(38)26-27(31)35-36-15-7-14-32-28(26)36)24-16-21-9-6-8-20(12-13-22-17-40-19(2)34-22)25(21)30(39)37(24)23-10-4-3-5-11-23/h3-11,14-18H,1-2H3,(H2,31,35)(H,33,38)/t18-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342501
PNG
(US10329299, Compound 66 | US9775844, Compound 66)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cocn3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C29H21N7O3/c1-18(33-28(37)25-26(30)34-35-14-6-13-31-27(25)35)23-15-20-8-5-7-19(11-12-21-16-39-17-32-21)24(20)29(38)36(23)22-9-3-2-4-10-22/h2-10,13-18H,1H3,(H2,30,34)(H,33,37)/t18-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM342539
PNG
(US10329299, Compound 90 | US9775844, Compound 90)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(NC(=O)c3cnn(C)c3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C29H25N9O3/c1-17(33-28(40)24-25(30)35-37-13-7-12-31-26(24)37)22-14-18-8-6-11-21(34-27(39)19-15-32-36(2)16-19)23(18)29(41)38(22)20-9-4-3-5-10-20/h3-17H,1-2H3,(H2,30,35)(H,33,40)(H,34,39)/t17-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342541
PNG
(US10329299, Compound 92 | US9775844, Compound 92)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(CC(=O)c3cn[nH]c3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C29H24N8O3/c1-17(34-28(39)25-26(30)35-36-12-6-11-31-27(25)36)22-13-18-7-5-8-19(14-23(38)20-15-32-33-16-20)24(18)29(40)37(22)21-9-3-2-4-10-21/h2-13,15-17H,14H2,1H3,(H2,30,35)(H,32,33)(H,34,39)/t17-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50192892
PNG
(CHEMBL3966879 | US10329299, Compound 5 | US9775844...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3ccccc3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C32H24N6O2/c1-21(35-31(39)28-29(33)36-37-19-9-18-34-30(28)37)26-20-24-13-8-12-23(17-16-22-10-4-2-5-11-22)27(24)32(40)38(26)25-14-6-3-7-15-25/h2-15,18-21H,1H3,(H2,33,36)(H,35,39)/t21-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50192892
PNG
(CHEMBL3966879 | US10329299, Compound 5 | US9775844...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3ccccc3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C32H24N6O2/c1-21(35-31(39)28-29(33)36-37-19-9-18-34-30(28)37)26-20-24-13-8-12-23(17-16-22-10-4-2-5-11-22)27(24)32(40)38(26)25-14-6-3-7-15-25/h2-15,18-21H,1H3,(H2,33,36)(H,35,39)/t21-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM340014
PNG
(US10329299, Compound 6 | US9775844, Compound 6)
Show SMILES COc1ccc(cn1)C#Cc1cccc2cc([C@H](C)NC(=O)c3c(N)nn4cccnc34)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C32H25N7O3/c1-20(36-31(40)28-29(33)37-38-17-7-16-34-30(28)38)25-18-23-9-6-8-22(14-12-21-13-15-26(42-2)35-19-21)27(23)32(41)39(25)24-10-4-3-5-11-24/h3-11,13,15-20H,1-2H3,(H2,33,37)(H,36,40)/t20-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM340015
PNG
(US10329299, Compound 7 | US9775844, Compound 7)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cncn3C)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C30H24N8O2/c1-19(34-29(39)26-27(31)35-37-15-7-14-33-28(26)37)24-16-21-9-6-8-20(12-13-23-17-32-18-36(23)2)25(21)30(40)38(24)22-10-4-3-5-11-22/h3-11,14-19H,1-2H3,(H2,31,35)(H,34,39)/t19-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM340016
PNG
(US10329299, Compound 8 | US9775844, Compound 8)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#CC(C)(C)N)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C29H27N7O2/c1-18(33-27(37)24-25(30)34-35-16-8-15-32-26(24)35)22-17-20-10-7-9-19(13-14-29(2,3)31)23(20)28(38)36(22)21-11-5-4-6-12-21/h4-12,15-18H,31H2,1-3H3,(H2,30,34)(H,33,37)/t18-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM342544
PNG
(US10329299, Compound 95 | US9775844, Compound 95)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2c(=O)n1-c1cccc(C)c1
Show InChI InChI=1/C31H26N8O2/c1-19-7-4-10-24(15-19)39-25(20(2)35-30(40)27-28(32)36-38-14-6-13-33-29(27)38)16-23-9-5-8-22(26(23)31(39)41)12-11-21-17-34-37(3)18-21/h4-10,13-18,20H,1-3H3,(H2,32,36)(H,35,40)/t20-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM342549
PNG
(US10329299, Compound 100 | US9775844, Compound 100)
Show SMILES CNS(=O)(=O)CCn1c(cc2cccc(C#Cc3cnn(C)c3)c2c1=O)[C@H](C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1/C27H27N9O4S/c1-17(32-26(37)23-24(28)33-36-11-5-10-30-25(23)36)21-14-20-7-4-6-19(9-8-18-15-31-34(3)16-18)22(20)27(38)35(21)12-13-41(39,40)29-2/h4-7,10-11,14-17,29H,12-13H2,1-3H3,(H2,28,33)(H,32,37)/t17-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342549
PNG
(US10329299, Compound 100 | US9775844, Compound 100)
Show SMILES CNS(=O)(=O)CCn1c(cc2cccc(C#Cc3cnn(C)c3)c2c1=O)[C@H](C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1/C27H27N9O4S/c1-17(32-26(37)23-24(28)33-36-11-5-10-30-25(23)36)21-14-20-7-4-6-19(9-8-18-15-31-34(3)16-18)22(20)27(38)35(21)12-13-41(39,40)29-2/h4-7,10-11,14-17,29H,12-13H2,1-3H3,(H2,28,33)(H,32,37)/t17-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM340018
PNG
(US10329299, Compound 10 | US9775844, Compound 10)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#CCN3CCOCC3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C31H29N7O3/c1-21(34-30(39)27-28(32)35-37-15-7-13-33-29(27)37)25-20-23-9-5-8-22(10-6-14-36-16-18-41-19-17-36)26(23)31(40)38(25)24-11-3-2-4-12-24/h2-5,7-9,11-13,15,20-21H,14,16-19H2,1H3,(H2,32,35)(H,34,39)/t21-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM340019
PNG
(US10329299, Compound 11 | US9775844, Compound 11)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#CC(C)(C)O)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C29H26N6O3/c1-18(32-27(36)24-25(30)33-34-16-8-15-31-26(24)34)22-17-20-10-7-9-19(13-14-29(2,3)38)23(20)28(37)35(22)21-11-5-4-6-12-21/h4-12,15-18,38H,1-3H3,(H2,30,33)(H,32,36)/t18-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM340021
PNG
(US10329299, Compound 13 | US9775844, Compound 13)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#CCO)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C27H22N6O3/c1-17(30-26(35)23-24(28)31-32-14-7-13-29-25(23)32)21-16-19-9-5-8-18(10-6-15-34)22(19)27(36)33(21)20-11-3-2-4-12-20/h2-5,7-9,11-14,16-17,34H,15H2,1H3,(H2,28,31)(H,30,35)/t17-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM340023
PNG
(US10329299, Compound 15 | US9775844, Compound 15)
Show SMILES C[C@@H](O)C#Cc1cccc2cc([C@H](C)NC(=O)c3c(N)nn4cccnc34)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C28H24N6O3/c1-17(35)12-13-19-8-6-9-20-16-22(34(28(37)23(19)20)21-10-4-3-5-11-21)18(2)31-27(36)24-25(29)32-33-15-7-14-30-26(24)33/h3-11,14-18,35H,1-2H3,(H2,29,32)(H,31,36)/t17-,18+/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM340024
PNG
(US10329299, Compound 16 | US9775844, Compound 16)
Show SMILES C[C@H](O)C#Cc1cccc2cc([C@H](C)NC(=O)c3c(N)nn4cccnc34)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1/C28H24N6O3/c1-17(35)12-13-19-8-6-9-20-16-22(34(28(37)23(19)20)21-10-4-3-5-11-21)18(2)31-27(36)24-25(29)32-33-15-7-14-30-26(24)33/h3-11,14-18,35H,1-2H3,(H2,29,32)(H,31,36)/t17-,18-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM342553
PNG
(US10329299, Compound 104 | US9775844, Compound 104)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2c(=O)n1CCS(=O)(=O)N(C)C
Show InChI InChI=1/C28H29N9O4S/c1-18(32-27(38)24-25(29)33-37-12-6-11-30-26(24)37)22-15-21-8-5-7-20(10-9-19-16-31-35(4)17-19)23(21)28(39)36(22)13-14-42(40,41)34(2)3/h5-8,11-12,15-18H,13-14H2,1-4H3,(H2,29,33)(H,32,38)/t18-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM342554
PNG
(US10329299, Compound 105 | US9775844, Compound 105)
Show SMILES CC[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C31H26N8O2/c1-3-24(35-30(40)27-28(32)36-38-16-8-15-33-29(27)38)25-17-22-10-7-9-21(14-13-20-18-34-37(2)19-20)26(22)31(41)39(25)23-11-5-4-6-12-23/h4-12,15-19,24H,3H2,1-2H3,(H2,32,36)(H,35,40)/t24-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM340027
PNG
(US10329299, Compound 19 | US9775844, Compound 19)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cn(C)nc3C)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C31H26N8O2/c1-19-23(18-37(3)35-19)14-13-21-9-7-10-22-17-25(39(31(41)26(21)22)24-11-5-4-6-12-24)20(2)34-30(40)27-28(32)36-38-16-8-15-33-29(27)38/h4-12,15-18,20H,1-3H3,(H2,32,36)(H,34,40)/t20-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342453
PNG
(US10329299, Compound 24 | US9775844, Compound 24)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#CC3CC3)c2c(=O)n1C1CC1
Show InChI InChI=1/C26H24N6O2/c1-15(29-25(33)22-23(27)30-31-13-3-12-28-24(22)31)20-14-18-5-2-4-17(9-8-16-6-7-16)21(18)26(34)32(20)19-10-11-19/h2-5,12-16,19H,6-7,10-11H2,1H3,(H2,27,30)(H,29,33)/t15-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM50192894
PNG
(CHEMBL3893430 | US10329299, Compound 32 | US977584...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3ccccn3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C31H23N7O2/c1-20(35-30(39)27-28(32)36-37-18-8-17-34-29(27)37)25-19-22-10-7-9-21(14-15-23-11-5-6-16-33-23)26(22)31(40)38(25)24-12-3-2-4-13-24/h2-13,16-20H,1H3,(H2,32,36)(H,35,39)/t20-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM342464
PNG
(US10329299, Compound 33 | US9775844, Compound 33)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3ccc(=O)[nH]c3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C31H23N7O3/c1-19(35-30(40)27-28(32)36-37-16-6-15-33-29(27)37)24-17-22-8-5-7-21(13-11-20-12-14-25(39)34-18-20)26(22)31(41)38(24)23-9-3-2-4-10-23/h2-10,12,14-19H,1H3,(H2,32,36)(H,34,39)(H,35,40)/t19-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM342467
PNG
(US10329299, Compound 36 | US9775844, Compound 36)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#CC=O)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C27H20N6O3/c1-17(30-26(35)23-24(28)31-32-14-7-13-29-25(23)32)21-16-19-9-5-8-18(10-6-15-34)22(19)27(36)33(21)20-11-3-2-4-12-20/h2-5,7-9,11-17H,1H3,(H2,28,31)(H,30,35)/t17-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM342469
PNG
(US10329299, Compound 38 | US9775844, Compound 38)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnc(C)n3C)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C31H26N8O2/c1-19(35-30(40)27-28(32)36-38-16-8-15-33-29(27)38)25-17-22-10-7-9-21(13-14-24-18-34-20(2)37(24)3)26(22)31(41)39(25)23-11-5-4-6-12-23/h4-12,15-19H,1-3H3,(H2,32,36)(H,35,40)/t19-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM342470
PNG
(US10329299, Compound 39 | US9775844, Compound 39)
Show SMILES C[C@H](NC(=O)c1cnn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C30H23N7O2/c1-20(34-29(38)25-18-33-36-15-7-14-31-28(25)36)26-16-23-9-6-8-22(13-12-21-17-32-35(2)19-21)27(23)30(39)37(26)24-10-4-3-5-11-24/h3-11,14-20H,1-2H3,(H,34,38)/t20-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM402893
PNG
(US10329299, Compound 43)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3ccn[nH]3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C29H22N8O2/c1-18(33-28(38)25-26(30)35-36-16-6-14-31-27(25)36)23-17-20-8-5-7-19(11-12-21-13-15-32-34-21)24(20)29(39)37(23)22-9-3-2-4-10-22/h2-10,13-18H,1H3,(H2,30,35)(H,32,34)(H,33,38)/t18-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM342476
PNG
(US10329299, Compound 44 | US9775844, Compound 44)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2c(=O)[nH]1
Show InChI InChI=1/C24H20N8O2/c1-14(28-24(34)20-21(25)30-32-10-4-9-26-22(20)32)18-11-17-6-3-5-16(19(17)23(33)29-18)8-7-15-12-27-31(2)13-15/h3-6,9-14H,1-2H3,(H2,25,30)(H,28,34)(H,29,33)/t14-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM342476
PNG
(US10329299, Compound 44 | US9775844, Compound 44)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2c(=O)[nH]1
Show InChI InChI=1/C24H20N8O2/c1-14(28-24(34)20-21(25)30-32-10-4-9-26-22(20)32)18-11-17-6-3-5-16(19(17)23(33)29-18)8-7-15-12-27-31(2)13-15/h3-6,9-14H,1-2H3,(H2,25,30)(H,28,34)(H,29,33)/t14-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM342485
PNG
(US10329299, Compound 52 | US9775844, Compound 52)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(\C=C\c3cnn(C)c3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C30H26N8O2/c1-19(34-29(39)26-27(31)35-37-15-7-14-32-28(26)37)24-16-22-9-6-8-21(13-12-20-17-33-36(2)18-20)25(22)30(40)38(24)23-10-4-3-5-11-23/h3-19H,1-2H3,(H2,31,35)(H,34,39)/b13-12+/t19-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342486
PNG
(US10329299, Compound 53 | US9775844, Compound 53)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(\C=C/c3cnn(C)c3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C30H26N8O2/c1-19(34-29(39)26-27(31)35-37-15-7-14-32-28(26)37)24-16-22-9-6-8-21(13-12-20-17-33-36(2)18-20)25(22)30(40)38(24)23-10-4-3-5-11-23/h3-19H,1-2H3,(H2,31,35)(H,34,39)/b13-12-/t19-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM342486
PNG
(US10329299, Compound 53 | US9775844, Compound 53)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(\C=C/c3cnn(C)c3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C30H26N8O2/c1-19(34-29(39)26-27(31)35-37-15-7-14-32-28(26)37)24-16-22-9-6-8-21(13-12-20-17-33-36(2)18-20)25(22)30(40)38(24)23-10-4-3-5-11-23/h3-19H,1-2H3,(H2,31,35)(H,34,39)/b13-12-/t19-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM342490
PNG
(US10329299, Compound 57 | US9775844, Compound 57)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#CCN(C)C)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C29H27N7O2/c1-19(32-28(37)25-26(30)33-35-17-9-15-31-27(25)35)23-18-21-11-7-10-20(12-8-16-34(2)3)24(21)29(38)36(23)22-13-5-4-6-14-22/h4-7,9-11,13-15,17-19H,16H2,1-3H3,(H2,30,33)(H,32,37)/t19-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM342492
PNG
(US10329299, Compound 58 | US9775844, Compound 58)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#CC(F)(F)F)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C27H19F3N6O2/c1-16(33-25(37)22-23(31)34-35-14-6-13-32-24(22)35)20-15-18-8-5-7-17(11-12-27(28,29)30)21(18)26(38)36(20)19-9-3-2-4-10-19/h2-10,13-16H,1H3,(H2,31,34)(H,33,37)/t16-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM50192908
PNG
(CHEMBL3895629 | US10329299, Compound 59 | US977584...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3nccs3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C29H21N7O2S/c1-18(33-28(37)25-26(30)34-35-15-6-13-32-27(25)35)22-17-20-8-5-7-19(11-12-23-31-14-16-39-23)24(20)29(38)36(22)21-9-3-2-4-10-21/h2-10,13-18H,1H3,(H2,30,34)(H,33,37)/t18-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50192908
PNG
(CHEMBL3895629 | US10329299, Compound 59 | US977584...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3nccs3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C29H21N7O2S/c1-18(33-28(37)25-26(30)34-35-15-6-13-32-27(25)35)22-17-20-8-5-7-19(11-12-23-31-14-16-39-23)24(20)29(38)36(22)21-9-3-2-4-10-21/h2-10,13-18H,1H3,(H2,30,34)(H,33,37)/t18-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM342501
PNG
(US10329299, Compound 66 | US9775844, Compound 66)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cocn3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C29H21N7O3/c1-18(33-28(37)25-26(30)34-35-14-6-13-31-27(25)35)23-15-20-8-5-7-19(11-12-21-16-39-17-32-21)24(20)29(38)36(23)22-9-3-2-4-10-22/h2-10,13-18H,1H3,(H2,30,34)(H,33,37)/t18-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM342516
PNG
(US10329299, Compound 67 | US9775844, Compound 67)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cccnc3C)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C32H25N7O2/c1-20-22(11-7-16-34-20)14-15-23-9-6-10-24-19-26(39(32(41)27(23)24)25-12-4-3-5-13-25)21(2)36-31(40)28-29(33)37-38-18-8-17-35-30(28)38/h3-13,16-19,21H,1-2H3,(H2,33,37)(H,36,40)/t21-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM342516
PNG
(US10329299, Compound 67 | US9775844, Compound 67)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cccnc3C)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C32H25N7O2/c1-20-22(11-7-16-34-20)14-15-23-9-6-10-24-19-26(39(32(41)27(23)24)25-12-4-3-5-13-25)21(2)36-31(40)28-29(33)37-38-18-8-17-35-30(28)38/h3-13,16-19,21H,1-2H3,(H2,33,37)(H,36,40)/t21-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM342517
PNG
(US10329299, Compound 68 | US9775844, Compound 68)
Show SMILES C[C@H](NC(=O)c1ncc(C)nc1N)c1cc2cccc(C#Cc3cnn(C)c3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C29H25N7O2/c1-18-15-31-26(27(30)33-18)28(37)34-19(2)24-14-22-9-7-8-21(13-12-20-16-32-35(3)17-20)25(22)29(38)36(24)23-10-5-4-6-11-23/h4-11,14-17,19H,1-3H3,(H2,30,33)(H,34,37)/t19-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM402921
PNG
(US10329299, Compound 71)
Show SMILES COc1cnc(C(=O)N[C@@H](C)c2cc3cccc(C#Cc4cnn(C)c4)c3c(=O)n2-c2ccccc2)c(N)n1
Show InChI InChI=1S/C29H25N7O3/c1-18(33-28(37)26-27(30)34-24(39-3)16-31-26)23-14-21-9-7-8-20(13-12-19-15-32-35(2)17-19)25(21)29(38)36(23)22-10-5-4-6-11-22/h4-11,14-18H,1-3H3,(H2,30,34)(H,33,37)/t18-/m0/s1
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial


(Homo sapiens (Human))
BDBM342524
PNG
(US10329299, Compound 75 | US9775844, Compound 75)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3scnc3C)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C30H23N7O2S/c1-18(34-29(38)26-27(31)35-36-15-7-14-32-28(26)36)23-16-21-9-6-8-20(12-13-24-19(2)33-17-40-24)25(21)30(39)37(23)22-10-4-3-5-11-22/h3-11,14-18H,1-2H3,(H2,31,35)(H,34,38)/t18-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM342526
PNG
(US10329299, Compound 77 | US9775844, Compound 77)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3ccc(C)nc3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C32H25N7O2/c1-20-12-13-22(19-35-20)14-15-23-8-6-9-24-18-26(39(32(41)27(23)24)25-10-4-3-5-11-25)21(2)36-31(40)28-29(33)37-38-17-7-16-34-30(28)38/h3-13,16-19,21H,1-2H3,(H2,33,37)(H,36,40)/t21-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM342531
PNG
(US10329299, Compound 82 | US9775844, Compound 82)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#CC3CCN(CC3)C(C)=O)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C33H31N7O3/c1-21(36-32(42)29-30(34)37-39-17-7-16-35-31(29)39)27-20-25-9-6-8-24(13-12-23-14-18-38(19-15-23)22(2)41)28(25)33(43)40(27)26-10-4-3-5-11-26/h3-11,16-17,20-21,23H,14-15,18-19H2,1-2H3,(H2,34,37)(H,36,42)/t21-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342534
PNG
(US10329299, Compound 85 | US9775844, Compound 85)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#CC3CCN(C)CC3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1/C32H31N7O2/c1-21(35-31(40)28-29(33)36-38-17-7-16-34-30(28)38)26-20-24-9-6-8-23(13-12-22-14-18-37(2)19-15-22)27(24)32(41)39(26)25-10-4-3-5-11-25/h3-11,16-17,20-22H,14-15,18-19H2,1-2H3,(H2,33,36)(H,35,40)/t21-/s2
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Infinity Pharmaceuticals, Inc.

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%