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Patent code US10329299

Compile Data Set for Download or QSAR

Found 436 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50192886
PNG
(CHEMBL3946030 | US10329299, Compound 70 | US106752...)
Show SMILES C\C=C\c1cccc2cc([C@H](C)NC(=O)c3c(N)nn4cccnc34)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1S/C27H24N6O2/c1-3-9-18-10-7-11-19-16-21(33(27(35)22(18)19)20-12-5-4-6-13-20)17(2)30-26(34)23-24(28)31-32-15-8-14-29-25(23)32/h3-17H,1-2H3,(H2,28,31)(H,30,34)/b9-3+/t17-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM402921
PNG
(US10329299, Compound 71)
Show SMILES COc1cnc(C(=O)N[C@@H](C)c2cc3cccc(C#Cc4cnn(C)c4)c3c(=O)n2-c2ccccc2)c(N)n1
Show InChI InChI=1S/C29H25N7O3/c1-18(33-28(37)26-27(30)34-24(39-3)16-31-26)23-14-21-9-7-8-20(13-12-19-15-32-35(2)17-19)25(21)29(38)36(23)22-10-5-4-6-11-22/h4-11,14-18H,1-3H3,(H2,30,34)(H,33,37)/t18-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM342526
PNG
(US10329299, Compound 77 | US10675286, Compound 77 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3ccc(C)nc3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C32H23N7O2/c1-20-12-13-22(19-35-20)14-15-23-8-6-9-24-18-26(39(32(41)27(23)24)25-10-4-3-5-11-25)21(2)36-31(40)28-29(33)37-38-17-7-16-34-30(28)38/h3-13,16-19,21H,1-2H3,(H,36,40)/t21-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342539
PNG
(US10329299, Compound 90 | US10675286, Compound 90 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(NC(=O)c3cnn(C)c3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C29H23N9O3/c1-17(33-28(40)24-25(30)35-37-13-7-12-31-26(24)37)22-14-18-8-6-11-21(34-27(39)19-15-32-36(2)16-19)23(18)29(41)38(22)20-9-4-3-5-10-20/h3-17H,1-2H3,(H,33,40)(H,34,39)/t17-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342542
PNG
(US10329299, Compound 93 | US10675286, Compound 93 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2c(=O)n1-c1cccc(F)c1
Show InChI InChI=1S/C30H21FN8O2/c1-18(35-29(40)26-27(32)36-38-13-5-12-33-28(26)38)24-14-21-7-3-6-20(11-10-19-16-34-37(2)17-19)25(21)30(41)39(24)23-9-4-8-22(31)15-23/h3-9,12-18H,1-2H3,(H,35,40)/t18-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM340015
PNG
(US10329299, Compound 7 | US10675286, Compound 7 | ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cncn3C)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C30H22N8O2/c1-19(34-29(39)26-27(31)35-37-15-7-14-33-28(26)37)24-16-21-9-6-8-20(12-13-23-17-32-18-36(23)2)25(21)30(40)38(24)22-10-4-3-5-11-22/h3-11,14-19H,1-2H3,(H,34,39)/t19-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM340015
PNG
(US10329299, Compound 7 | US10675286, Compound 7 | ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cncn3C)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C30H22N8O2/c1-19(34-29(39)26-27(31)35-37-15-7-14-33-28(26)37)24-16-21-9-6-8-20(12-13-23-17-32-18-36(23)2)25(21)30(40)38(24)22-10-4-3-5-11-22/h3-11,14-19H,1-2H3,(H,34,39)/t19-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM340016
PNG
(US10329299, Compound 8 | US10675286, Compound 8 | ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#CC(C)(C)N)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C29H25N7O2/c1-18(33-27(37)24-25(30)34-35-16-8-15-32-26(24)35)22-17-20-10-7-9-19(13-14-29(2,3)31)23(20)28(38)36(22)21-11-5-4-6-12-21/h4-12,15-18H,31H2,1-3H3,(H,33,37)/t18-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM340017
PNG
(US10329299, Compound 9 | US10675286, Compound 9 | ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#CC3CC3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C29H22N6O2/c1-18(32-28(36)25-26(30)33-34-16-6-15-31-27(25)34)23-17-21-8-5-7-20(14-13-19-11-12-19)24(21)29(37)35(23)22-9-3-2-4-10-22/h2-10,15-19H,11-12H2,1H3,(H,32,36)/t18-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM340021
PNG
(US10329299, Compound 13 | US10675286, Compound 13 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#CCO)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C27H20N6O3/c1-17(30-26(35)23-24(28)31-32-14-7-13-29-25(23)32)21-16-19-9-5-8-18(10-6-15-34)22(19)27(36)33(21)20-11-3-2-4-12-20/h2-5,7-9,11-14,16-17,34H,15H2,1H3,(H,30,35)/t17-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM340024
PNG
(US10329299, Compound 16 | US10675286, Compound 16 ...)
Show SMILES C[C@H](O)C#Cc1cccc2cc([C@H](C)NC(=O)c3c(N)nn4cccnc34)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1S/C28H22N6O3/c1-17(35)12-13-19-8-6-9-20-16-22(34(28(37)23(19)20)21-10-4-3-5-11-21)18(2)31-27(36)24-25(29)32-33-15-7-14-30-26(24)33/h3-11,14-18,35H,1-2H3,(H,31,36)/t17-,18-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50192895
PNG
(CHEMBL3928146 | US10329299, Compound 17 | US106752...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cccnc3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C31H23N7O2/c1-20(35-30(39)27-28(32)36-37-17-7-16-34-29(27)37)25-18-23-10-5-9-22(14-13-21-8-6-15-33-19-21)26(23)31(40)38(25)24-11-3-2-4-12-24/h2-12,15-20H,1H3,(H2,32,36)(H,35,39)/t20-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM342556
PNG
(US10329299, Compound 107 | US10675286, Compound 10...)
Show SMILES Cn1cc(cn1)C#Cc1cccc2cc(CNC(=O)c3c(N)nn4cccnc34)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1S/C29H22N8O2/c1-35-18-19(16-33-35)11-12-20-7-5-8-21-15-23(37(29(39)24(20)21)22-9-3-2-4-10-22)17-32-28(38)25-26(30)34-36-14-6-13-31-27(25)36/h2-10,13-16,18H,17H2,1H3,(H2,30,34)(H,32,38)
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM342558
PNG
(US10329299, Compound 109 | US10675286, Compound 10...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(N)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C24H19N7O2/c1-14(28-23(32)20-21(26)29-30-12-6-11-27-22(20)30)18-13-15-7-5-10-17(25)19(15)24(33)31(18)16-8-3-2-4-9-16/h2-14H,25H2,1H3,(H,28,32)/t14-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM340026
PNG
(US10329299, Compound 18 | US10675286, Compound 18 ...)
Show SMILES COc1ncc(cn1)C#Cc1cccc2cc([C@H](C)NC(=O)c3c(N)nn4cccnc34)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1S/C31H22N8O3/c1-19(36-29(40)26-27(32)37-38-15-7-14-33-28(26)38)24-16-22-9-6-8-21(13-12-20-17-34-31(42-2)35-18-20)25(22)30(41)39(24)23-10-4-3-5-11-23/h3-11,14-19H,1-2H3,(H,36,40)/t19-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM340028
PNG
(US10329299, Compound 20 | US10675286, Compound 20 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3ccc(=O)n(C)c3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C32H23N7O3/c1-20(35-31(41)28-29(33)36-38-17-7-16-34-30(28)38)25-18-23-9-6-8-22(14-12-21-13-15-26(40)37(2)19-21)27(23)32(42)39(25)24-10-4-3-5-11-24/h3-11,13,15-20H,1-2H3,(H,35,41)/t20-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50192880
PNG
(CHEMBL3984425 | US10329299, Compound 21 | US106752...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C30H24N8O2/c1-19(34-29(39)26-27(31)35-37-15-7-14-32-28(26)37)24-16-22-9-6-8-21(13-12-20-17-33-36(2)18-20)25(22)30(40)38(24)23-10-4-3-5-11-23/h3-11,14-19H,1-2H3,(H2,31,35)(H,34,39)/t19-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342452
PNG
(US10329299, Compound 23 | US10675286, Compound 23 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cncn3C)c2c(=O)n1C1CC1
Show InChI InChI=1S/C27H22N8O2/c1-16(31-26(36)23-24(28)32-34-12-4-11-30-25(23)34)21-13-18-6-3-5-17(7-8-20-14-29-15-33(20)2)22(18)27(37)35(21)19-9-10-19/h3-6,11-16,19H,9-10H2,1-2H3,(H,31,36)/t16-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM342452
PNG
(US10329299, Compound 23 | US10675286, Compound 23 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cncn3C)c2c(=O)n1C1CC1
Show InChI InChI=1S/C27H22N8O2/c1-16(31-26(36)23-24(28)32-34-12-4-11-30-25(23)34)21-13-18-6-3-5-17(7-8-20-14-29-15-33(20)2)22(18)27(37)35(21)19-9-10-19/h3-6,11-16,19H,9-10H2,1-2H3,(H,31,36)/t16-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM342454
PNG
(US10329299, Compound 25 | US10675286, Compound 25 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2c(=O)n1C1CC1
Show InChI InChI=1S/C27H22N8O2/c1-16(31-26(36)23-24(28)32-34-12-4-11-29-25(23)34)21-13-19-6-3-5-18(8-7-17-14-30-33(2)15-17)22(19)27(37)35(21)20-9-10-20/h3-6,11-16,20H,9-10H2,1-2H3,(H,31,36)/t16-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342458
PNG
(US10329299, Compound 27 | US10675286, Compound 27 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#CC3CCOCC3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C31H26N6O3/c1-20(34-30(38)27-28(32)35-36-16-6-15-33-29(27)36)25-19-23-8-5-7-22(12-11-21-13-17-40-18-14-21)26(23)31(39)37(25)24-9-3-2-4-10-24/h2-10,15-16,19-21H,13-14,17-18H2,1H3,(H,34,38)/t20-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM342459
PNG
(US10329299, Compound 28 | US10675286, Compound 28 ...)
Show SMILES COc1cc(ccn1)C#Cc1cccc2cc([C@H](C)NC(=O)c3c(N)nn4cccnc34)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1S/C32H23N7O3/c1-20(36-31(40)28-29(33)37-38-17-7-15-35-30(28)38)25-19-23-9-6-8-22(13-12-21-14-16-34-26(18-21)42-2)27(23)32(41)39(25)24-10-4-3-5-11-24/h3-11,14-20H,1-2H3,(H,36,40)/t20-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM342460
PNG
(US10329299, Compound 29 | US10675286, Compound 29 ...)
Show SMILES C[C@H](NC(=O)c1nccnc1N)c1cc2cccc(C#Cc3cnn(C)c3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C28H21N7O2/c1-18(33-27(36)25-26(29)31-14-13-30-25)23-15-21-8-6-7-20(12-11-19-16-32-34(2)17-19)24(21)28(37)35(23)22-9-4-3-5-10-22/h3-10,13-18H,1-2H3,(H,33,36)/t18-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342465
PNG
(US10329299, Compound 34 | US10675286, Compound 34 ...)
Show SMILES CCOC(OCC)C#Cc1cccc2cc([C@H](C)NC(=O)c3c(N)nn4cccnc34)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1S/C31H30N6O4/c1-4-40-25(41-5-2)16-15-21-11-9-12-22-19-24(37(31(39)26(21)22)23-13-7-6-8-14-23)20(3)34-30(38)27-28(32)35-36-18-10-17-33-29(27)36/h6-14,17-20,25H,4-5H2,1-3H3,(H2,32,35)(H,34,38)/t20-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM342466
PNG
(US10329299, Compound 35 | US10675286, Compound 35 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3C)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C31H24N8O2/c1-19(35-30(40)27-28(32)36-38-16-8-15-33-29(27)38)25-17-22-10-7-9-21(13-14-23-18-34-37(3)20(23)2)26(22)31(41)39(25)24-11-5-4-6-12-24/h4-12,15-19H,1-3H3,(H,35,40)/t19-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342467
PNG
(US10329299, Compound 36 | US10675286, Compound 36 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#CC=O)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C27H18N6O3/c1-17(30-26(35)23-24(28)31-32-14-7-13-29-25(23)32)21-16-19-9-5-8-18(10-6-15-34)22(19)27(36)33(21)20-11-3-2-4-12-20/h2-5,7-9,11-17H,1H3,(H,30,35)/t17-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM342470
PNG
(US10329299, Compound 39 | US10675286, Compound 39 ...)
Show SMILES C[C@H](NC(=O)c1cnn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C30H23N7O2/c1-20(34-29(38)25-18-33-36-15-7-14-31-28(25)36)26-16-23-9-6-8-22(13-12-21-17-32-35(2)19-21)27(23)30(39)37(26)24-10-4-3-5-11-24/h3-11,14-20H,1-2H3,(H,34,38)/t20-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342470
PNG
(US10329299, Compound 39 | US10675286, Compound 39 ...)
Show SMILES C[C@H](NC(=O)c1cnn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C30H23N7O2/c1-20(34-29(38)25-18-33-36-15-7-14-31-28(25)36)26-16-23-9-6-8-22(13-12-21-17-32-35(2)19-21)27(23)30(39)37(26)24-10-4-3-5-11-24/h3-11,14-20H,1-2H3,(H,34,38)/t20-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342471
PNG
(US10329299, Compound 63 | US10675286, Compound 40 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3csc(C)n3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C30H21N7O2S/c1-18(33-29(38)26-27(31)35-36-15-7-14-32-28(26)36)24-16-21-9-6-8-20(12-13-22-17-40-19(2)34-22)25(21)30(39)37(24)23-10-4-3-5-11-23/h3-11,14-18H,1-2H3,(H,33,38)/t18-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342476
PNG
(US10329299, Compound 44 | US10675286, Compound 44 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2c(=O)[nH]1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM342477
PNG
(US10329299, Compound 45 | US10675286, Compound 45 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1nc2cccc(C#C)c2c(=O)n1-c1ccc(F)c(F)c1
Show InChI InChI=1S/C25H15F2N7O2/c1-3-14-6-4-7-18-19(14)25(36)34(15-8-9-16(26)17(27)12-15)22(31-18)13(2)30-24(35)20-21(28)32-33-11-5-10-29-23(20)33/h1,4-13H,2H3,(H,30,35)/t13-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342478
PNG
(US10329299, Compound 46 | US10675286, Compound 46 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1nc2cccc(C#C)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C25H17N7O2/c1-3-16-9-7-12-18-19(16)25(34)32(17-10-5-4-6-11-17)22(29-18)15(2)28-24(33)20-21(26)30-31-14-8-13-27-23(20)31/h1,4-15H,2H3,(H,28,33)/t15-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM342480
PNG
(US10329299, Compound 48 | US10675286, Compound 48 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1nc2cccc(C#C)c2c(=O)n1C
Show InChI InChI=1S/C20H15N7O2/c1-4-12-7-5-8-13-14(12)20(29)26(3)17(24-13)11(2)23-19(28)15-16(21)25-27-10-6-9-22-18(15)27/h1,5-11H,2-3H3,(H,23,28)/t11-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM342481
PNG
(US10329299, Compound 49 | US10675286, Compound 49 ...)
Show SMILES C[C@H](NC(=O)c1nccnc1N)c1nc2cccc(C#C)c2c(=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C23H15FN6O2/c1-3-14-5-4-6-17-18(14)23(32)30(16-9-7-15(24)8-10-16)21(29-17)13(2)28-22(31)19-20(25)27-12-11-26-19/h1,4-13H,2H3,(H,28,31)/t13-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM342489
PNG
(US10329299, Compound 56 | US10675286, Compound 56 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#CCN3CCN(C)CC3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C32H30N8O2/c1-22(35-31(41)28-29(33)36-39-16-8-14-34-30(28)39)26-21-24-10-6-9-23(11-7-15-38-19-17-37(2)18-20-38)27(24)32(42)40(26)25-12-4-3-5-13-25/h3-6,8-10,12-14,16,21-22H,15,17-20H2,1-2H3,(H,35,41)/t22-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM342496
PNG
(US10329299, Compound 62 | US10675286, Compound 62 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#CC3(O)CN4CCC3CC4)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C33H29N7O3/c1-21(36-31(41)28-29(34)37-39-16-6-15-35-30(28)39)26-19-23-8-5-7-22(11-14-33(43)20-38-17-12-24(33)13-18-38)27(23)32(42)40(26)25-9-3-2-4-10-25/h2-10,15-16,19,21,24,43H,12-13,17-18,20H2,1H3,(H,36,41)/t21-,33?/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM342471
PNG
(US10329299, Compound 63 | US10675286, Compound 40 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3csc(C)n3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C30H21N7O2S/c1-18(33-29(38)26-27(31)35-36-15-7-14-32-28(26)36)24-16-21-9-6-8-20(12-13-22-17-40-19(2)34-22)25(21)30(39)37(24)23-10-4-3-5-11-23/h3-11,14-18H,1-2H3,(H,33,38)/t18-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342516
PNG
(US10329299, Compound 67 | US10675286, Compound 67 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cccnc3C)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C32H23N7O2/c1-20-22(11-7-16-34-20)14-15-23-9-6-10-24-19-26(39(32(41)27(23)24)25-12-4-3-5-13-25)21(2)36-31(40)28-29(33)37-38-18-8-17-35-30(28)38/h3-13,16-19,21H,1-2H3,(H,36,40)/t21-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50192886
PNG
(CHEMBL3946030 | US10329299, Compound 70 | US106752...)
Show SMILES C\C=C\c1cccc2cc([C@H](C)NC(=O)c3c(N)nn4cccnc34)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1S/C27H24N6O2/c1-3-9-18-10-7-11-19-16-21(33(27(35)22(18)19)20-12-5-4-6-13-20)17(2)30-26(34)23-24(28)31-32-15-8-14-29-25(23)32/h3-17H,1-2H3,(H2,28,31)(H,30,34)/b9-3+/t17-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342524
PNG
(US10329299, Compound 75 | US10675286, Compound 75 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3scnc3C)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C30H21N7O2S/c1-18(34-29(38)26-27(31)35-36-15-7-14-32-28(26)36)23-16-21-9-6-8-20(12-13-24-19(2)33-17-40-24)25(21)30(39)37(23)22-10-4-3-5-11-22/h3-11,14-18H,1-2H3,(H,34,38)/t18-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342526
PNG
(US10329299, Compound 77 | US10675286, Compound 77 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3ccc(C)nc3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C32H23N7O2/c1-20-12-13-22(19-35-20)14-15-23-8-6-9-24-18-26(39(32(41)27(23)24)25-10-4-3-5-11-25)21(2)36-31(40)28-29(33)37-38-17-7-16-34-30(28)38/h3-13,16-19,21H,1-2H3,(H,36,40)/t21-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342527
PNG
(US10329299, Compound 78 | US10675286, Compound 78 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3ncsc3C)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C30H21N7O2S/c1-18(34-29(38)26-27(31)35-36-15-7-14-32-28(26)36)24-16-21-9-6-8-20(12-13-23-19(2)40-17-33-23)25(21)30(39)37(24)22-10-4-3-5-11-22/h3-11,14-18H,1-2H3,(H,34,38)/t18-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM342527
PNG
(US10329299, Compound 78 | US10675286, Compound 78 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3ncsc3C)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C30H21N7O2S/c1-18(34-29(38)26-27(31)35-36-15-7-14-32-28(26)36)24-16-21-9-6-8-20(12-13-23-19(2)40-17-33-23)25(21)30(39)37(24)22-10-4-3-5-11-22/h3-11,14-18H,1-2H3,(H,34,38)/t18-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM342528
PNG
(US10329299, Compound 79 | US10675286, Compound 79 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3sc(C)nc3C)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C31H23N7O2S/c1-18(35-30(39)27-28(32)36-37-16-8-15-33-29(27)37)24-17-22-10-7-9-21(13-14-25-19(2)34-20(3)41-25)26(22)31(40)38(24)23-11-5-4-6-12-23/h4-12,15-18H,1-3H3,(H,35,39)/t18-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM342532
PNG
(US10329299, Compound 83 | US10675286, Compound 83 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#CC3CCN(CC3)S(C)(=O)=O)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C32H29N7O4S/c1-21(35-31(40)28-29(33)36-38-17-7-16-34-30(28)38)26-20-24-9-6-8-23(13-12-22-14-18-37(19-15-22)44(2,42)43)27(24)32(41)39(26)25-10-4-3-5-11-25/h3-11,16-17,20-22H,14-15,18-19H2,1-2H3,(H,35,40)/t21-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM342532
PNG
(US10329299, Compound 83 | US10675286, Compound 83 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#CC3CCN(CC3)S(C)(=O)=O)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C32H29N7O4S/c1-21(35-31(40)28-29(33)36-38-17-7-16-34-30(28)38)26-20-24-9-6-8-23(13-12-22-14-18-37(19-15-22)44(2,42)43)27(24)32(41)39(26)25-10-4-3-5-11-25/h3-11,16-17,20-22H,14-15,18-19H2,1-2H3,(H,35,40)/t21-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM342533
PNG
(US10329299, Compound 84 | US10675286, Compound 84 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#CC3CCOC3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C30H24N6O3/c1-19(33-29(37)26-27(31)34-35-15-6-14-32-28(26)35)24-17-22-8-5-7-21(12-11-20-13-16-39-18-20)25(22)30(38)36(24)23-9-3-2-4-10-23/h2-10,14-15,17,19-20H,13,16,18H2,1H3,(H,33,37)/t19-,20?/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM339971
PNG
(US10329299, Compound 1 | US10675286, Compound 1 | ...)
Show SMILES CC#Cc1cccc2nc([C@H](C)NC(=O)c3c(N)nn4cccnc34)n(-c3ccccc3)c(=O)c12
Show InChI InChI=1S/C26H19N7O2/c1-3-9-17-10-7-13-19-20(17)26(35)33(18-11-5-4-6-12-18)23(30-19)16(2)29-25(34)21-22(27)31-32-15-8-14-28-24(21)32/h4-8,10-16H,1-2H3,(H,29,34)/t16-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM342536
PNG
(US10329299, Compound 87 | US10675286, Compound 87 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(\C=C\c3ccccc3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C32H24N6O2/c1-21(35-31(39)28-29(33)36-37-19-9-18-34-30(28)37)26-20-24-13-8-12-23(17-16-22-10-4-2-5-11-22)27(24)32(40)38(26)25-14-6-3-7-15-25/h2-21H,1H3,(H,35,39)/b17-16+/t21-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM342536
PNG
(US10329299, Compound 87 | US10675286, Compound 87 ...)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(\C=C\c3ccccc3)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C32H24N6O2/c1-21(35-31(39)28-29(33)36-37-19-9-18-34-30(28)37)26-20-24-13-8-12-23(17-16-22-10-4-2-5-11-22)27(24)32(40)38(26)25-14-6-3-7-15-25/h2-21H,1H3,(H,35,39)/b17-16+/t21-/m0/s1
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Infinity Pharmaceuticals Inc

US Patent


Assay Description
A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec...


US Patent US10329299 (2019)


BindingDB Entry DOI: 10.7270/Q2KK9F5S
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 436 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%