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Patent code US10329307

Compile Data Set for Download or QSAR
Found 74 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403299
PNG
(US10329307, Example 46)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCCN3c3ccc(cc3)C#N)cc(OC)cc2o1
Show InChI InChI=1S/C27H25N5O4S/c1-33-20-11-23(35-16-19-5-3-4-10-31(19)18-8-6-17(14-28)7-9-18)21-13-25(36-24(21)12-20)22-15-32-26(29-22)37-27(30-32)34-2/h6-9,11-13,15,19H,3-5,10,16H2,1-2H3
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n/an/a 240n/an/an/an/an/an/a



Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403270
PNG
(US10329307, Example 17)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCCN3c3ccc(OC)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H26N4O5S/c1-31-18-8-6-16(7-9-18)29-10-4-5-17(29)15-34-22-11-19(32-2)12-23-20(22)13-24(35-23)21-14-30-25(27-21)36-26(28-30)33-3/h6-9,11-14,17H,4-5,10,15H2,1-3H3/t17-/m0/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403298
PNG
(US10329307, Example 45)
Show SMILES CCOC(=O)c1ccc(cc1)N1CCCCC1COc1cc(OC)cc2oc(cc12)-c1cn2nc(OC)sc2n1
Show InChI InChI=1S/C29H30N4O6S/c1-4-37-27(34)18-8-10-19(11-9-18)32-12-6-5-7-20(32)17-38-24-13-21(35-2)14-25-22(24)15-26(39-25)23-16-33-28(30-23)40-29(31-33)36-3/h8-11,13-16,20H,4-7,12,17H2,1-3H3
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Universite de Montreal

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403263
PNG
(US10329307, Example 10)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@H]3CCCN3c3ccc(OC)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H26N4O5S/c1-31-18-8-6-16(7-9-18)29-10-4-5-17(29)15-34-22-11-19(32-2)12-23-20(22)13-24(35-23)21-14-30-25(27-21)36-26(28-30)33-3/h6-9,11-14,17H,4-5,10,15H2,1-3H3/t17-/m1/s1
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Universite de Montreal

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403265
PNG
(US10329307, Example 12)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@H]3CCCN3c3ccc4OCOc4c3)cc(OC)cc2o1
Show InChI InChI=1S/C26H24N4O6S/c1-31-17-9-21(33-13-16-4-3-7-29(16)15-5-6-20-24(8-15)35-14-34-20)18-11-23(36-22(18)10-17)19-12-30-25(27-19)37-26(28-30)32-2/h5-6,8-12,16H,3-4,7,13-14H2,1-2H3/t16-/m1/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403254
PNG
(US10329307, Example 1)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@H]3CCCN3c3ccc(cc3)C#N)cc(OC)cc2o1
Show InChI InChI=1S/C26H23N5O4S/c1-32-19-10-22(34-15-18-4-3-9-30(18)17-7-5-16(13-27)6-8-17)20-12-24(35-23(20)11-19)21-14-31-25(28-21)36-26(29-31)33-2/h5-8,10-12,14,18H,3-4,9,15H2,1-2H3/t18-/m1/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403286
PNG
(US10329307, Example 33)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ccc(Cl)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H25ClN4O4S/c1-32-19-10-22(34-15-16-4-3-9-30(13-16)18-7-5-17(27)6-8-18)20-12-24(35-23(20)11-19)21-14-31-25(28-21)36-26(29-31)33-2/h5-8,10-12,14,16H,3-4,9,13,15H2,1-2H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403275
PNG
(US10329307, Example 22)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCCN3c3ccc(cc3)C(F)(F)F)cc(OC)cc2o1
Show InChI InChI=1S/C26H23F3N4O4S/c1-34-18-10-21(36-14-17-4-3-9-32(17)16-7-5-15(6-8-16)26(27,28)29)19-12-23(37-22(19)11-18)20-13-33-24(30-20)38-25(31-33)35-2/h5-8,10-13,17H,3-4,9,14H2,1-2H3/t17-/m0/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403272
PNG
(US10329307, Example 19)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCCN3c3cccc(OC)c3)cc(OC)cc2o1
Show InChI InChI=1S/C26H26N4O5S/c1-31-18-8-4-6-16(10-18)29-9-5-7-17(29)15-34-22-11-19(32-2)12-23-20(22)13-24(35-23)21-14-30-25(27-21)36-26(28-30)33-3/h4,6,8,10-14,17H,5,7,9,15H2,1-3H3/t17-/m0/s1
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Universite de Montreal

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403271
PNG
(US10329307, Example 18)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCCN3c3ccc(F)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C25H23FN4O4S/c1-31-18-10-21(33-14-17-4-3-9-29(17)16-7-5-15(26)6-8-16)19-12-23(34-22(19)11-18)20-13-30-24(27-20)35-25(28-30)32-2/h5-8,10-13,17H,3-4,9,14H2,1-2H3/t17-/m0/s1
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Universite de Montreal

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403296
PNG
(US10329307, Example 43)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3cc(ccn3)C#N)cc(OC)cc2o1
Show InChI InChI=1S/C26H24N6O4S/c1-33-18-9-21(35-15-17-4-3-7-31(13-17)24-8-16(12-27)5-6-28-24)19-11-23(36-22(19)10-18)20-14-32-25(29-20)37-26(30-32)34-2/h5-6,8-11,14,17H,3-4,7,13,15H2,1-2H3
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Universite de Montreal

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403269
PNG
(US10329307, Example 16)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCCN3c3ccc(cc3)C#N)cc(OC)cc2o1
Show InChI InChI=1S/C26H23N5O4S/c1-32-19-10-22(34-15-18-4-3-9-30(18)17-7-5-16(13-27)6-8-17)20-12-24(35-23(20)11-19)21-14-31-25(28-21)36-26(29-31)33-2/h5-8,10-12,14,18H,3-4,9,15H2,1-2H3/t18-/m0/s1
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Universite de Montreal

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403292
PNG
(US10329307, Example 39)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ccc(cc3)C(F)(F)F)cc(OC)cc2o1
Show InChI InChI=1S/C27H25F3N4O4S/c1-35-19-10-22(20-12-24(38-23(20)11-19)21-14-34-25(31-21)39-26(32-34)36-2)37-15-16-4-3-9-33(13-16)18-7-5-17(6-8-18)27(28,29)30/h5-8,10-12,14,16H,3-4,9,13,15H2,1-2H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403291
PNG
(US10329307, Example 38)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ccc4OCOc4c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H26N4O6S/c1-32-18-9-22(19-11-24(37-23(19)10-18)20-13-31-26(28-20)38-27(29-31)33-2)34-14-16-4-3-7-30(12-16)17-5-6-21-25(8-17)36-15-35-21/h5-6,8-11,13,16H,3-4,7,12,14-15H2,1-2H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403274
PNG
(US10329307, Example 21)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCCN3c3ccc4OCOc4c3)cc(OC)cc2o1
Show InChI InChI=1S/C26H24N4O6S/c1-31-17-9-21(33-13-16-4-3-7-29(16)15-5-6-20-24(8-15)35-14-34-20)18-11-23(36-22(18)10-17)19-12-30-25(27-19)37-26(28-30)32-2/h5-6,8-12,16H,3-4,7,13-14H2,1-2H3/t16-/m0/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403266
PNG
(US10329307, Example 13)
Show SMILES CCOC(=O)c1ccc(cc1)N1CCC[C@@H]1COc1cc(OC)cc2oc(cc12)-c1cn2nc(OC)sc2n1
Show InChI InChI=1S/C28H28N4O6S/c1-4-36-26(33)17-7-9-18(10-8-17)31-11-5-6-19(31)16-37-23-12-20(34-2)13-24-21(23)14-25(38-24)22-15-32-27(29-22)39-28(30-32)35-3/h7-10,12-15,19H,4-6,11,16H2,1-3H3/t19-/m1/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403290
PNG
(US10329307, Example 37)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ncc(F)cc3F)cc(OC)cc2o1
Show InChI InChI=1S/C25H23F2N5O4S/c1-33-16-7-20(35-13-14-4-3-5-31(11-14)23-18(27)6-15(26)10-28-23)17-9-22(36-21(17)8-16)19-12-32-24(29-19)37-25(30-32)34-2/h6-10,12,14H,3-5,11,13H2,1-2H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403276
PNG
(US10329307, Example 23)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCCN3c3ccc(OC(F)(F)F)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H23F3N4O5S/c1-34-18-10-21(19-12-23(37-22(19)11-18)20-13-33-24(30-20)39-25(31-33)35-2)36-14-16-4-3-9-32(16)15-5-7-17(8-6-15)38-26(27,28)29/h5-8,10-13,16H,3-4,9,14H2,1-2H3/t16-/m0/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403287
PNG
(US10329307, Example 34)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCCN(C3)c3ccc(Cl)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H25ClN4O4S/c1-32-19-10-22(34-15-16-4-3-9-30(13-16)18-7-5-17(27)6-8-18)20-12-24(35-23(20)11-19)21-14-31-25(28-21)36-26(29-31)33-2/h5-8,10-12,14,16H,3-4,9,13,15H2,1-2H3/t16-/m1/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403273
PNG
(US10329307, Example 20)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCCN3c3ccc(OC)cn3)cc(OC)cc2o1
Show InChI InChI=1S/C25H25N5O5S/c1-31-16-6-7-23(26-12-16)29-8-4-5-15(29)14-34-20-9-17(32-2)10-21-18(20)11-22(35-21)19-13-30-24(27-19)36-25(28-30)33-3/h6-7,9-13,15H,4-5,8,14H2,1-3H3/t15-/m0/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403308
PNG
(US10329307, Example 55 | US10329307, Example 56 | ...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCCN3c3ccc(Cl)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H25ClN4O4S/c1-32-19-11-22(34-15-18-5-3-4-10-30(18)17-8-6-16(27)7-9-17)20-13-24(35-23(20)12-19)21-14-31-25(28-21)36-26(29-31)33-2/h6-9,11-14,18H,3-5,10,15H2,1-2H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403308
PNG
(US10329307, Example 55 | US10329307, Example 56 | ...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCCN3c3ccc(Cl)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H25ClN4O4S/c1-32-19-11-22(34-15-18-5-3-4-10-30(18)17-8-6-16(27)7-9-17)20-13-24(35-23(20)12-19)21-14-31-25(28-21)36-26(29-31)33-2/h6-9,11-14,18H,3-5,10,15H2,1-2H3
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403264
PNG
(US10329307, Example 11)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@H]3CCCN3c3ccc(F)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C25H23FN4O4S/c1-31-18-10-21(33-14-17-4-3-9-29(17)16-7-5-15(26)6-8-16)19-12-23(34-22(19)11-18)20-13-30-24(27-20)35-25(28-30)32-2/h5-8,10-13,17H,3-4,9,14H2,1-2H3/t17-/m1/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403297
PNG
(US10329307, Example 44)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCCN(C3)c3ccc(cn3)C#N)cc(OC)cc2o1
Show InChI InChI=1S/C26H24N6O4S/c1-33-18-8-21(35-15-17-4-3-7-31(13-17)24-6-5-16(11-27)12-28-24)19-10-23(36-22(19)9-18)20-14-32-25(29-20)37-26(30-32)34-2/h5-6,8-10,12,14,17H,3-4,7,13,15H2,1-2H3/t17-/m1/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403289
PNG
(US10329307, Example 36)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ccc(OC)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C27H28N4O5S/c1-32-19-8-6-18(7-9-19)30-10-4-5-17(14-30)16-35-23-11-20(33-2)12-24-21(23)13-25(36-24)22-15-31-26(28-22)37-27(29-31)34-3/h6-9,11-13,15,17H,4-5,10,14,16H2,1-3H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403278
PNG
(US10329307, Example 25)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCN(C3)c3ccc(Cl)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C25H23ClN4O4S/c1-31-18-9-21(33-14-15-7-8-29(12-15)17-5-3-16(26)4-6-17)19-11-23(34-22(19)10-18)20-13-30-24(27-20)35-25(28-30)32-2/h3-6,9-11,13,15H,7-8,12,14H2,1-2H3/t15-/m1/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403316
PNG
(US10329307, Example 63 | US10329307, Example 64 | ...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ccc(Cl)cn3)cc(OC)cc2o1
Show InChI InChI=1S/C25H24ClN5O4S/c1-32-17-8-20(34-14-15-4-3-7-30(12-15)23-6-5-16(26)11-27-23)18-10-22(35-21(18)9-17)19-13-31-24(28-19)36-25(29-31)33-2/h5-6,8-11,13,15H,3-4,7,12,14H2,1-2H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403288
PNG
(US10329307, Example 35)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@H]3CCCN(C3)c3ccc(Cl)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H25ClN4O4S/c1-32-19-10-22(34-15-16-4-3-9-30(13-16)18-7-5-17(27)6-8-18)20-12-24(35-23(20)11-19)21-14-31-25(28-21)36-26(29-31)33-2/h5-8,10-12,14,16H,3-4,9,13,15H2,1-2H3/t16-/m0/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403283
PNG
(US10329307, Example 30)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@H]3CCCN(C3)c3ccc(cc3)C#N)cc(OC)cc2o1
Show InChI InChI=1S/C27H25N5O4S/c1-33-20-10-23(35-16-18-4-3-9-31(14-18)19-7-5-17(13-28)6-8-19)21-12-25(36-24(21)11-20)22-15-32-26(29-22)37-27(30-32)34-2/h5-8,10-12,15,18H,3-4,9,14,16H2,1-2H3/t18-/m0/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403316
PNG
(US10329307, Example 63 | US10329307, Example 64 | ...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ccc(Cl)cn3)cc(OC)cc2o1
Show InChI InChI=1S/C25H24ClN5O4S/c1-32-17-8-20(34-14-15-4-3-7-30(12-15)23-6-5-16(26)11-27-23)18-10-22(35-21(18)9-17)19-13-31-24(28-19)36-25(29-31)33-2/h5-6,8-11,13,15H,3-4,7,12,14H2,1-2H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403284
PNG
(US10329307, Example 31)
Show SMILES CCOC(=O)c1ccc(cc1)N1CCC[C@H](COc2cc(OC)cc3oc(cc23)-c2cn3nc(OC)sc3n2)C1
Show InChI InChI=1S/C29H30N4O6S/c1-4-37-27(34)19-7-9-20(10-8-19)32-11-5-6-18(15-32)17-38-24-12-21(35-2)13-25-22(24)14-26(39-25)23-16-33-28(30-23)40-29(31-33)36-3/h7-10,12-14,16,18H,4-6,11,15,17H2,1-3H3/t18-/m0/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403308
PNG
(US10329307, Example 55 | US10329307, Example 56 | ...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCCN3c3ccc(Cl)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H25ClN4O4S/c1-32-19-11-22(34-15-18-5-3-4-10-30(18)17-8-6-16(27)7-9-17)20-13-24(35-23(20)12-19)21-14-31-25(28-21)36-26(29-31)33-2/h6-9,11-14,18H,3-5,10,15H2,1-2H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403262
PNG
(US10329307, Example 9)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@H]3CCCN3c3ccc(Cl)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C25H23ClN4O4S/c1-31-18-10-21(33-14-17-4-3-9-29(17)16-7-5-15(26)6-8-16)19-12-23(34-22(19)11-18)20-13-30-24(27-20)35-25(28-30)32-2/h5-8,10-13,17H,3-4,9,14H2,1-2H3/t17-/m1/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403282
PNG
(US10329307, Example 29)
Show SMILES CCOC(=O)c1ccc(cc1)N1CCC[C@@H](COc2cc(OC)cc3oc(cc23)-c2cn3nc(OC)sc3n2)C1
Show InChI InChI=1S/C29H30N4O6S/c1-4-37-27(34)19-7-9-20(10-8-19)32-11-5-6-18(15-32)17-38-24-12-21(35-2)13-25-22(24)14-26(39-25)23-16-33-28(30-23)40-29(31-33)36-3/h7-10,12-14,16,18H,4-6,11,15,17H2,1-3H3/t18-/m1/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403277
PNG
(US10329307, Example 24)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCCN3c3ccc(C)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H26N4O4S/c1-16-6-8-17(9-7-16)29-10-4-5-18(29)15-33-22-11-19(31-2)12-23-20(22)13-24(34-23)21-14-30-25(27-21)35-26(28-30)32-3/h6-9,11-14,18H,4-5,10,15H2,1-3H3/t18-/m0/s1
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403300
PNG
(US10329307, Example 47)
Show SMILES CCOC(=O)c1ccc(cc1)N1CCC(COc2cc(OC)cc3oc(cc23)-c2cn3nc(OC)sc3n2)CC1
Show InChI InChI=1S/C29H30N4O6S/c1-4-37-27(34)19-5-7-20(8-6-19)32-11-9-18(10-12-32)17-38-24-13-21(35-2)14-25-22(24)15-26(39-25)23-16-33-28(30-23)40-29(31-33)36-3/h5-8,13-16,18H,4,9-12,17H2,1-3H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403316
PNG
(US10329307, Example 63 | US10329307, Example 64 | ...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ccc(Cl)cn3)cc(OC)cc2o1
Show InChI InChI=1S/C25H24ClN5O4S/c1-32-17-8-20(34-14-15-4-3-7-30(12-15)23-6-5-16(26)11-27-23)18-10-22(35-21(18)9-17)19-13-31-24(28-19)36-25(29-31)33-2/h5-6,8-11,13,15H,3-4,7,12,14H2,1-2H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403305
PNG
(US10329307, Example 52)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@H]3CCCN(C3)c3ccc(F)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H25FN4O4S/c1-32-19-10-22(34-15-16-4-3-9-30(13-16)18-7-5-17(27)6-8-18)20-12-24(35-23(20)11-19)21-14-31-25(28-21)36-26(29-31)33-2/h5-8,10-12,14,16H,3-4,9,13,15H2,1-2H3/t16-/m0/s1
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403295
PNG
(US10329307, Example 42)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ccc(OC)cc3OC)cc(OC)cc2o1
Show InChI InChI=1S/C28H30N4O6S/c1-33-18-7-8-22(26(10-18)35-3)31-9-5-6-17(14-31)16-37-23-11-19(34-2)12-24-20(23)13-25(38-24)21-15-32-27(29-21)39-28(30-32)36-4/h7-8,10-13,15,17H,5-6,9,14,16H2,1-4H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403301
PNG
(US10329307, Example 48)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCN(CC3)c3ccc(cc3)C#N)cc(OC)cc2o1
Show InChI InChI=1S/C27H25N5O4S/c1-33-20-11-23(35-16-18-7-9-31(10-8-18)19-5-3-17(14-28)4-6-19)21-13-25(36-24(21)12-20)22-15-32-26(29-22)37-27(30-32)34-2/h3-6,11-13,15,18H,7-10,16H2,1-2H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403256
PNG
(US10329307, Example 3)
Show SMILES COc1ccc(cc1)N1CCN(CC1COc1cc(OC)cc2oc(cc12)-c1cn2nc(C)ccc2n1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C33H37N5O6/c1-21-7-12-31-34-27(19-38(31)35-21)30-17-26-28(15-25(41-6)16-29(26)43-30)42-20-23-18-36(32(39)44-33(2,3)4)13-14-37(23)22-8-10-24(40-5)11-9-22/h7-12,15-17,19,23H,13-14,18,20H2,1-6H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403312
PNG
(US10329307, Example 59)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@H]3CCCN(C3)C(=O)OCc3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C28H28N4O6S/c1-34-20-11-23(21-13-25(38-24(21)12-20)22-15-32-26(29-22)39-27(30-32)35-2)36-17-19-9-6-10-31(14-19)28(33)37-16-18-7-4-3-5-8-18/h3-5,7-8,11-13,15,19H,6,9-10,14,16-17H2,1-2H3/t19-/m0/s1
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403324
PNG
(US10329307, Example 71)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ccc(NC(=O)C(F)(F)F)nc3)cc(OC)cc2o1
Show InChI InChI=1S/C27H25F3N6O5S/c1-38-17-8-20(18-10-22(41-21(18)9-17)19-13-36-25(32-19)42-26(34-36)39-2)40-14-15-4-3-7-35(12-15)16-5-6-23(31-11-16)33-24(37)27(28,29)30/h5-6,8-11,13,15H,3-4,7,12,14H2,1-2H3,(H,31,33,37)
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403268
PNG
(US10329307, Example 15)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCCN3c3ccc(Cl)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C25H23ClN4O4S/c1-31-18-10-21(33-14-17-4-3-9-29(17)16-7-5-15(26)6-8-16)19-12-23(34-22(19)11-18)20-13-30-24(27-20)35-25(28-30)32-2/h5-8,10-13,17H,3-4,9,14H2,1-2H3/t17-/m0/s1
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403293
PNG
(US10329307, Example 40)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ccc(cc3)C#N)cc(OC)cc2o1
Show InChI InChI=1S/C27H25N5O4S/c1-33-20-10-23(35-16-18-4-3-9-31(14-18)19-7-5-17(13-28)6-8-19)21-12-25(36-24(21)11-20)22-15-32-26(29-22)37-27(30-32)34-2/h5-8,10-12,15,18H,3-4,9,14,16H2,1-2H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403319
PNG
(US10329307, Example 66)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ncc(Br)cn3)cc(OC)cc2o1
Show InChI InChI=1S/C24H23BrN6O4S/c1-32-16-6-19(34-13-14-4-3-5-30(11-14)22-26-9-15(25)10-27-22)17-8-21(35-20(17)7-16)18-12-31-23(28-18)36-24(29-31)33-2/h6-10,12,14H,3-5,11,13H2,1-2H3
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Universite de Montreal

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403311
PNG
(US10329307, Example 58)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@H]3CCCN(Cc4ccc(Cl)cc4)C3)cc(OC)cc2o1
Show InChI InChI=1S/C27H27ClN4O4S/c1-33-20-10-23(35-16-18-4-3-9-31(14-18)13-17-5-7-19(28)8-6-17)21-12-25(36-24(21)11-20)22-15-32-26(29-22)37-27(30-32)34-2/h5-8,10-12,15,18H,3-4,9,13-14,16H2,1-2H3/t18-/m0/s1
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403325
PNG
(US10329307, Example 72)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCCN(C3)c3ccc(F)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H25FN4O4S/c1-32-19-10-22(34-15-16-4-3-9-30(13-16)18-7-5-17(27)6-8-18)20-12-24(35-23(20)11-19)21-14-31-25(28-21)36-26(29-31)33-2/h5-8,10-12,14,16H,3-4,9,13,15H2,1-2H3/t16-/m1/s1
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403279
PNG
(US10329307, Example 26)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCN(C3)c3ccc(OC)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H26N4O5S/c1-31-18-6-4-17(5-7-18)29-9-8-16(13-29)15-34-22-10-19(32-2)11-23-20(22)12-24(35-23)21-14-30-25(27-21)36-26(28-30)33-3/h4-7,10-12,14,16H,8-9,13,15H2,1-3H3/t16-/m1/s1
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403307
PNG
(US10329307, Example 54)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@H]3CCCN(C3)c3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H26N4O4S/c1-31-19-11-22(33-16-17-7-6-10-29(14-17)18-8-4-3-5-9-18)20-13-24(34-23(20)12-19)21-15-30-25(27-21)35-26(28-30)32-2/h3-5,8-9,11-13,15,17H,6-7,10,14,16H2,1-2H3/t17-/m0/s1
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403261
PNG
(US10329307, Example 8)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)S(=O)(=O)c3ccc(C)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C27H28N4O6S2/c1-17-6-8-20(9-7-17)39(32,33)30-10-4-5-18(14-30)16-36-23-11-19(34-2)12-24-21(23)13-25(37-24)22-15-31-26(28-22)38-27(29-31)35-3/h6-9,11-13,15,18H,4-5,10,14,16H2,1-3H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403314
PNG
(US10329307, Example 61)
Show SMILES CCOC(=O)c1cnc(s1)N1CCCC(COc2cc(OC)cc3oc(cc23)-c2cn3nc(OC)sc3n2)C1
Show InChI InChI=1S/C26H27N5O6S2/c1-4-35-23(32)22-11-27-24(38-22)30-7-5-6-15(12-30)14-36-19-8-16(33-2)9-20-17(19)10-21(37-20)18-13-31-25(28-18)39-26(29-31)34-3/h8-11,13,15H,4-7,12,14H2,1-3H3
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403306
PNG
(US10329307, Example 53)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCCN(C3)c3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H26N4O4S/c1-31-19-11-22(33-16-17-7-6-10-29(14-17)18-8-4-3-5-9-18)20-13-24(34-23(20)12-19)21-15-30-25(27-21)35-26(28-30)32-2/h3-5,8-9,11-13,15,17H,6-7,10,14,16H2,1-2H3/t17-/m1/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403281
PNG
(US10329307, Example 28)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCCN(C3)c3ccc(cc3)C#N)cc(OC)cc2o1
Show InChI InChI=1S/C27H25N5O4S/c1-33-20-10-23(35-16-18-4-3-9-31(14-18)19-7-5-17(13-28)6-8-19)21-12-25(36-24(21)11-20)22-15-32-26(29-22)37-27(30-32)34-2/h5-8,10-12,15,18H,3-4,9,14,16H2,1-2H3/t18-/m1/s1
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403315
PNG
(US10329307, Example 62)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ncc(Br)s3)cc(OC)cc2o1
Show InChI InChI=1S/C23H22BrN5O4S2/c1-30-14-6-17(32-12-13-4-3-5-28(10-13)21-25-9-20(24)34-21)15-8-19(33-18(15)7-14)16-11-29-22(26-16)35-23(27-29)31-2/h6-9,11,13H,3-5,10,12H2,1-2H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403321
PNG
(US10329307, Example 68)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ccc(NC(=O)OC(C)(C)C)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C31H35N5O6S/c1-31(2,3)42-29(37)32-20-8-10-21(11-9-20)35-12-6-7-19(16-35)18-40-25-13-22(38-4)14-26-23(25)15-27(41-26)24-17-36-28(33-24)43-30(34-36)39-5/h8-11,13-15,17,19H,6-7,12,16,18H2,1-5H3,(H,32,37)
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403294
PNG
(US10329307, Example 41)
Show SMILES CCOC(=O)c1ccc(cc1)N1CCCC(COc2cc(OC)cc3oc(cc23)-c2cn3nc(OC)sc3n2)C1
Show InChI InChI=1S/C29H30N4O6S/c1-4-37-27(34)19-7-9-20(10-8-19)32-11-5-6-18(15-32)17-38-24-12-21(35-2)13-25-22(24)14-26(39-25)23-16-33-28(30-23)40-29(31-33)36-3/h7-10,12-14,16,18H,4-6,11,15,17H2,1-3H3
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UniChem
US Patent
n/an/a 2.10E+3n/an/an/an/an/an/a



Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403280
PNG
(US10329307, Example 27)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CN(C3)c3ccc(F)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C24H21FN4O4S/c1-30-17-7-20(32-13-14-10-28(11-14)16-5-3-15(25)4-6-16)18-9-22(33-21(18)8-17)19-12-29-23(26-19)34-24(27-29)31-2/h3-9,12,14H,10-11,13H2,1-2H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403313
PNG
(US10329307, Example 60)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3nncs3)cc(OC)cc2o1
Show InChI InChI=1S/C22H22N6O4S2/c1-29-14-6-17(31-11-13-4-3-5-27(9-13)21-25-23-12-33-21)15-8-19(32-18(15)7-14)16-10-28-20(24-16)34-22(26-28)30-2/h6-8,10,12-13H,3-5,9,11H2,1-2H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403302
PNG
(US10329307, Example 49)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCN(CC3)c3ccc(Cl)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H25ClN4O4S/c1-32-19-11-22(34-15-16-7-9-30(10-8-16)18-5-3-17(27)4-6-18)20-13-24(35-23(20)12-19)21-14-31-25(28-21)36-26(29-31)33-2/h3-6,11-14,16H,7-10,15H2,1-2H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403285
PNG
(US10329307, Example 32)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ccc(OC)cn3)cc(OC)cc2o1
Show InChI InChI=1S/C26H27N5O5S/c1-32-17-6-7-24(27-12-17)30-8-4-5-16(13-30)15-35-21-9-18(33-2)10-22-19(21)11-23(36-22)20-14-31-25(28-20)37-26(29-31)34-3/h6-7,9-12,14,16H,4-5,8,13,15H2,1-3H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403322
PNG
(US10329307, Example 69)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ccc(NC(=O)OC(C)(C)C)nc3)cc(OC)cc2o1
Show InChI InChI=1S/C30H34N6O6S/c1-30(2,3)42-28(37)33-26-9-8-19(14-31-26)35-10-6-7-18(15-35)17-40-23-11-20(38-4)12-24-21(23)13-25(41-24)22-16-36-27(32-22)43-29(34-36)39-5/h8-9,11-14,16,18H,6-7,10,15,17H2,1-5H3,(H,31,33,37)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403320
PNG
(US10329307, Example 67)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCC(=O)N(C3)c3ccc(Cl)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H23ClN4O5S/c1-33-18-9-21(35-14-15-3-8-24(32)30(12-15)17-6-4-16(27)5-7-17)19-11-23(36-22(19)10-18)20-13-31-25(28-20)37-26(29-31)34-2/h4-7,9-11,13,15H,3,8,12,14H2,1-2H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403323
PNG
(US10329307, Example 70)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ccc(OCc4ccc(OC)cc4)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C34H34N4O6S/c1-39-25-10-6-22(7-11-25)20-42-26-12-8-24(9-13-26)37-14-4-5-23(18-37)21-43-30-15-27(40-2)16-31-28(30)17-32(44-31)29-19-38-33(35-29)45-34(36-38)41-3/h6-13,15-17,19,23H,4-5,14,18,20-21H2,1-3H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403303
PNG
(US10329307, Example 50)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCN(CC3)c3ccc(F)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H25FN4O4S/c1-32-19-11-22(34-15-16-7-9-30(10-8-16)18-5-3-17(27)4-6-18)20-13-24(35-23(20)12-19)21-14-31-25(28-21)36-26(29-31)33-2/h3-6,11-14,16H,7-10,15H2,1-2H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403304
PNG
(US10329307, Example 51)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCN(CC3)c3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H26N4O4S/c1-31-19-12-22(33-16-17-8-10-29(11-9-17)18-6-4-3-5-7-18)20-14-24(34-23(20)13-19)21-15-30-25(27-21)35-26(28-30)32-2/h3-7,12-15,17H,8-11,16H2,1-2H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403255
PNG
(US10329307, Example 2)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@H]3CCCN3C3CCOCC3)cc(OC)cc2o1
Show InChI InChI=1S/C24H28N4O5S/c1-29-17-10-20(32-14-16-4-3-7-27(16)15-5-8-31-9-6-15)18-12-22(33-21(18)11-17)19-13-28-23(25-19)34-24(26-28)30-2/h10-13,15-16H,3-9,14H2,1-2H3/t16-/m1/s1
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n/an/a 9.40E+3n/an/an/an/an/an/a



Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403267
PNG
(US10329307, Example 14)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@H]3CCC(=O)N3c3ccc(F)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C25H21FN4O5S/c1-32-17-9-20(34-13-16-7-8-23(31)30(16)15-5-3-14(26)4-6-15)18-11-22(35-21(18)10-17)19-12-29-24(27-19)36-25(28-29)33-2/h3-6,9-12,16H,7-8,13H2,1-2H3/t16-/m1/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403259
PNG
(US10329307, Example 6)
Show SMILES COc1ccc(cc1)N1CCN(CC1COc1cc(OC)cc2oc(cc12)-c1cn2nc(C)ccc2n1)C(=O)C1CC1
Show InChI InChI=1S/C32H33N5O5/c1-20-4-11-31-33-27(18-37(31)34-20)30-16-26-28(14-25(40-3)15-29(26)42-30)41-19-23-17-35(32(38)21-5-6-21)12-13-36(23)22-7-9-24(39-2)10-8-22/h4,7-11,14-16,18,21,23H,5-6,12-13,17,19H2,1-3H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403260
PNG
(US10329307, Example 7)
Show SMILES COc1ccc(cc1)N1CCN(CC2CC2)CC1COc1cc(OC)cc2oc(cc12)-c1cn2nc(C)ccc2n1
Show InChI InChI=1S/C32H35N5O4/c1-21-4-11-32-33-28(19-37(32)34-21)31-16-27-29(14-26(39-3)15-30(27)41-31)40-20-24-18-35(17-22-5-6-22)12-13-36(24)23-7-9-25(38-2)10-8-23/h4,7-11,14-16,19,22,24H,5-6,12-13,17-18,20H2,1-3H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403258
PNG
(US10329307, Example 5)
Show SMILES COc1ccc(cc1)N1CCN(CC1COc1cc(OC)cc2oc(cc12)-c1cn2nc(C)ccc2n1)C(=O)c1ccccc1
Show InChI InChI=1S/C35H33N5O5/c1-23-9-14-34-36-30(21-40(34)37-23)33-19-29-31(17-28(43-3)18-32(29)45-33)44-22-26-20-38(35(41)24-7-5-4-6-8-24)15-16-39(26)25-10-12-27(42-2)13-11-25/h4-14,17-19,21,26H,15-16,20,22H2,1-3H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403327
PNG
(US10329307, Example 74)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ccc(N)nc3)cc(OC)cc2o1
Show InChI InChI=1S/C25H26N6O4S/c1-32-17-8-20(34-14-15-4-3-7-30(12-15)16-5-6-23(26)27-11-16)18-10-22(35-21(18)9-17)19-13-31-24(28-19)36-25(29-31)33-2/h5-6,8-11,13,15H,3-4,7,12,14H2,1-2H3,(H2,26,27)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403326
PNG
(US10329307, Example 73)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)C3CCOCC3)cc(OC)cc2o1
Show InChI InChI=1S/C25H30N4O5S/c1-30-18-10-21(33-15-16-4-3-7-28(13-16)17-5-8-32-9-6-17)19-12-23(34-22(19)11-18)20-14-29-24(26-20)35-25(27-29)31-2/h10-12,14,16-17H,3-9,13,15H2,1-2H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))		BDBM403257
PNG
(US10329307, Example 4)
Show SMILES COc1ccc(cc1)N1CCNCC1COc1cc(OC)cc2oc(cc12)-c1cn2nc(C)ccc2n1
Show InChI InChI=1S/C28H29N5O4/c1-18-4-9-28-30-24(16-33(28)31-18)27-14-23-25(12-22(35-3)13-26(23)37-27)36-17-20-15-29-10-11-32(20)19-5-7-21(34-2)8-6-19/h4-9,12-14,16,20,29H,10-11,15,17H2,1-3H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...

US Patent US10329307 (2019)


BindingDB Entry DOI: 10.7270/Q26975XD
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%