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Patent code US10329307

Compile Data Set for Download or QSAR
Found 74 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403299
PNG
(US10329307, Example 46)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCCN3c3ccc(cc3)C#N)cc(OC)cc2o1
Show InChI InChI=1S/C27H25N5O4S/c1-33-20-11-23(35-16-19-5-3-4-10-31(19)18-8-6-17(14-28)7-9-18)21-13-25(36-24(21)12-20)22-15-32-26(29-22)37-27(30-32)34-2/h6-9,11-13,15,19H,3-5,10,16H2,1-2H3
MMDB

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n/an/a 240n/an/an/an/an/an/a



Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403270
PNG
(US10329307, Example 17)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCCN3c3ccc(OC)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H26N4O5S/c1-31-18-8-6-16(7-9-18)29-10-4-5-17(29)15-34-22-11-19(32-2)12-23-20(22)13-24(35-23)21-14-30-25(27-21)36-26(28-30)33-3/h6-9,11-14,17H,4-5,10,15H2,1-3H3/t17-/m0/s1
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n/an/a 290n/an/an/an/an/an/a



Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403298
PNG
(US10329307, Example 45)
Show SMILES CCOC(=O)c1ccc(cc1)N1CCCCC1COc1cc(OC)cc2oc(cc12)-c1cn2nc(OC)sc2n1
Show InChI InChI=1S/C29H30N4O6S/c1-4-37-27(34)18-8-10-19(11-9-18)32-12-6-5-7-20(32)17-38-24-13-21(35-2)14-25-22(24)15-26(39-25)23-16-33-28(30-23)40-29(31-33)36-3/h8-11,13-16,20H,4-7,12,17H2,1-3H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403263
PNG
(US10329307, Example 10)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@H]3CCCN3c3ccc(OC)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H26N4O5S/c1-31-18-8-6-16(7-9-18)29-10-4-5-17(29)15-34-22-11-19(32-2)12-23-20(22)13-24(35-23)21-14-30-25(27-21)36-26(28-30)33-3/h6-9,11-14,17H,4-5,10,15H2,1-3H3/t17-/m1/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403265
PNG
(US10329307, Example 12)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@H]3CCCN3c3ccc4OCOc4c3)cc(OC)cc2o1
Show InChI InChI=1S/C26H24N4O6S/c1-31-17-9-21(33-13-16-4-3-7-29(16)15-5-6-20-24(8-15)35-14-34-20)18-11-23(36-22(18)10-17)19-12-30-25(27-19)37-26(28-30)32-2/h5-6,8-12,16H,3-4,7,13-14H2,1-2H3/t16-/m1/s1
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n/an/a 420n/an/an/an/an/an/a



Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403254
PNG
(US10329307, Example 1)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@H]3CCCN3c3ccc(cc3)C#N)cc(OC)cc2o1
Show InChI InChI=1S/C26H23N5O4S/c1-32-19-10-22(34-15-18-4-3-9-30(18)17-7-5-16(13-27)6-8-17)20-12-24(35-23(20)11-19)21-14-31-25(28-21)36-26(29-31)33-2/h5-8,10-12,14,18H,3-4,9,15H2,1-2H3/t18-/m1/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403286
PNG
(US10329307, Example 33)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ccc(Cl)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H25ClN4O4S/c1-32-19-10-22(34-15-16-4-3-9-30(13-16)18-7-5-17(27)6-8-18)20-12-24(35-23(20)11-19)21-14-31-25(28-21)36-26(29-31)33-2/h5-8,10-12,14,16H,3-4,9,13,15H2,1-2H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403275
PNG
(US10329307, Example 22)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCCN3c3ccc(cc3)C(F)(F)F)cc(OC)cc2o1
Show InChI InChI=1S/C26H23F3N4O4S/c1-34-18-10-21(36-14-17-4-3-9-32(17)16-7-5-15(6-8-16)26(27,28)29)19-12-23(37-22(19)11-18)20-13-33-24(30-20)38-25(31-33)35-2/h5-8,10-13,17H,3-4,9,14H2,1-2H3/t17-/m0/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403272
PNG
(US10329307, Example 19)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCCN3c3cccc(OC)c3)cc(OC)cc2o1
Show InChI InChI=1S/C26H26N4O5S/c1-31-18-8-4-6-16(10-18)29-9-5-7-17(29)15-34-22-11-19(32-2)12-23-20(22)13-24(35-23)21-14-30-25(27-21)36-26(28-30)33-3/h4,6,8,10-14,17H,5,7,9,15H2,1-3H3/t17-/m0/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403271
PNG
(US10329307, Example 18)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCCN3c3ccc(F)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C25H23FN4O4S/c1-31-18-10-21(33-14-17-4-3-9-29(17)16-7-5-15(26)6-8-16)19-12-23(34-22(19)11-18)20-13-30-24(27-20)35-25(28-30)32-2/h5-8,10-13,17H,3-4,9,14H2,1-2H3/t17-/m0/s1
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n/an/a 470n/an/an/an/an/an/a



Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403296
PNG
(US10329307, Example 43)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3cc(ccn3)C#N)cc(OC)cc2o1
Show InChI InChI=1S/C26H24N6O4S/c1-33-18-9-21(35-15-17-4-3-7-31(13-17)24-8-16(12-27)5-6-28-24)19-11-23(36-22(19)10-18)20-14-32-25(29-20)37-26(30-32)34-2/h5-6,8-11,14,17H,3-4,7,13,15H2,1-2H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403269
PNG
(US10329307, Example 16)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCCN3c3ccc(cc3)C#N)cc(OC)cc2o1
Show InChI InChI=1S/C26H23N5O4S/c1-32-19-10-22(34-15-18-4-3-9-30(18)17-7-5-16(13-27)6-8-17)20-12-24(35-23(20)11-19)21-14-31-25(28-21)36-26(29-31)33-2/h5-8,10-12,14,18H,3-4,9,15H2,1-2H3/t18-/m0/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403292
PNG
(US10329307, Example 39)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ccc(cc3)C(F)(F)F)cc(OC)cc2o1
Show InChI InChI=1S/C27H25F3N4O4S/c1-35-19-10-22(20-12-24(38-23(20)11-19)21-14-34-25(31-21)39-26(32-34)36-2)37-15-16-4-3-9-33(13-16)18-7-5-17(6-8-18)27(28,29)30/h5-8,10-12,14,16H,3-4,9,13,15H2,1-2H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403291
PNG
(US10329307, Example 38)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ccc4OCOc4c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H26N4O6S/c1-32-18-9-22(19-11-24(37-23(19)10-18)20-13-31-26(28-20)38-27(29-31)33-2)34-14-16-4-3-7-30(12-16)17-5-6-21-25(8-17)36-15-35-21/h5-6,8-11,13,16H,3-4,7,12,14-15H2,1-2H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403274
PNG
(US10329307, Example 21)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCCN3c3ccc4OCOc4c3)cc(OC)cc2o1
Show InChI InChI=1S/C26H24N4O6S/c1-31-17-9-21(33-13-16-4-3-7-29(16)15-5-6-20-24(8-15)35-14-34-20)18-11-23(36-22(18)10-17)19-12-30-25(27-19)37-26(28-30)32-2/h5-6,8-12,16H,3-4,7,13-14H2,1-2H3/t16-/m0/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403266
PNG
(US10329307, Example 13)
Show SMILES CCOC(=O)c1ccc(cc1)N1CCC[C@@H]1COc1cc(OC)cc2oc(cc12)-c1cn2nc(OC)sc2n1
Show InChI InChI=1S/C28H28N4O6S/c1-4-36-26(33)17-7-9-18(10-8-17)31-11-5-6-19(31)16-37-23-12-20(34-2)13-24-21(23)14-25(38-24)22-15-32-27(29-22)39-28(30-32)35-3/h7-10,12-15,19H,4-6,11,16H2,1-3H3/t19-/m1/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403290
PNG
(US10329307, Example 37)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ncc(F)cc3F)cc(OC)cc2o1
Show InChI InChI=1S/C25H23F2N5O4S/c1-33-16-7-20(35-13-14-4-3-5-31(11-14)23-18(27)6-15(26)10-28-23)17-9-22(36-21(17)8-16)19-12-32-24(29-19)37-25(30-32)34-2/h6-10,12,14H,3-5,11,13H2,1-2H3
MMDB

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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403276
PNG
(US10329307, Example 23)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCCN3c3ccc(OC(F)(F)F)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H23F3N4O5S/c1-34-18-10-21(19-12-23(37-22(19)11-18)20-13-33-24(30-20)39-25(31-33)35-2)36-14-16-4-3-9-32(16)15-5-7-17(8-6-15)38-26(27,28)29/h5-8,10-13,16H,3-4,9,14H2,1-2H3/t16-/m0/s1
MMDB

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n/an/a 600n/an/an/an/an/an/a



Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403287
PNG
(US10329307, Example 34)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCCN(C3)c3ccc(Cl)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H25ClN4O4S/c1-32-19-10-22(34-15-16-4-3-9-30(13-16)18-7-5-17(27)6-8-18)20-12-24(35-23(20)11-19)21-14-31-25(28-21)36-26(29-31)33-2/h5-8,10-12,14,16H,3-4,9,13,15H2,1-2H3/t16-/m1/s1
MMDB

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n/an/a 700n/an/an/an/an/an/a



Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403273
PNG
(US10329307, Example 20)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCCN3c3ccc(OC)cn3)cc(OC)cc2o1
Show InChI InChI=1S/C25H25N5O5S/c1-31-16-6-7-23(26-12-16)29-8-4-5-15(29)14-34-20-9-17(32-2)10-21-18(20)11-22(35-21)19-13-30-24(27-19)36-25(28-30)33-3/h6-7,9-13,15H,4-5,8,14H2,1-3H3/t15-/m0/s1
MMDB

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403308
PNG
(US10329307, Example 55 | US10329307, Example 56 | ...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCCN3c3ccc(Cl)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H25ClN4O4S/c1-32-19-11-22(34-15-18-5-3-4-10-30(18)17-8-6-16(27)7-9-17)20-13-24(35-23(20)12-19)21-14-31-25(28-21)36-26(29-31)33-2/h6-9,11-14,18H,3-5,10,15H2,1-2H3
MMDB

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403308
PNG
(US10329307, Example 55 | US10329307, Example 56 | ...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCCN3c3ccc(Cl)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H25ClN4O4S/c1-32-19-11-22(34-15-18-5-3-4-10-30(18)17-8-6-16(27)7-9-17)20-13-24(35-23(20)12-19)21-14-31-25(28-21)36-26(29-31)33-2/h6-9,11-14,18H,3-5,10,15H2,1-2H3
MMDB

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Universite de Montreal

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403264
PNG
(US10329307, Example 11)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@H]3CCCN3c3ccc(F)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C25H23FN4O4S/c1-31-18-10-21(33-14-17-4-3-9-29(17)16-7-5-15(26)6-8-16)19-12-23(34-22(19)11-18)20-13-30-24(27-20)35-25(28-30)32-2/h5-8,10-13,17H,3-4,9,14H2,1-2H3/t17-/m1/s1
MMDB

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Universite de Montreal

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403297
PNG
(US10329307, Example 44)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCCN(C3)c3ccc(cn3)C#N)cc(OC)cc2o1
Show InChI InChI=1S/C26H24N6O4S/c1-33-18-8-21(35-15-17-4-3-7-31(13-17)24-6-5-16(11-27)12-28-24)19-10-23(36-22(19)9-18)20-14-32-25(29-20)37-26(30-32)34-2/h5-6,8-10,12,14,17H,3-4,7,13,15H2,1-2H3/t17-/m1/s1
MMDB

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403289
PNG
(US10329307, Example 36)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ccc(OC)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C27H28N4O5S/c1-32-19-8-6-18(7-9-19)30-10-4-5-17(14-30)16-35-23-11-20(33-2)12-24-21(23)13-25(36-24)22-15-31-26(28-22)37-27(29-31)34-3/h6-9,11-13,15,17H,4-5,10,14,16H2,1-3H3
MMDB

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403278
PNG
(US10329307, Example 25)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCN(C3)c3ccc(Cl)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C25H23ClN4O4S/c1-31-18-9-21(33-14-15-7-8-29(12-15)17-5-3-16(26)4-6-17)19-11-23(34-22(19)10-18)20-13-30-24(27-20)35-25(28-30)32-2/h3-6,9-11,13,15H,7-8,12,14H2,1-2H3/t15-/m1/s1
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Universite de Montreal

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403316
PNG
(US10329307, Example 63 | US10329307, Example 64 | ...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ccc(Cl)cn3)cc(OC)cc2o1
Show InChI InChI=1S/C25H24ClN5O4S/c1-32-17-8-20(34-14-15-4-3-7-30(12-15)23-6-5-16(26)11-27-23)18-10-22(35-21(18)9-17)19-13-31-24(28-19)36-25(29-31)33-2/h5-6,8-11,13,15H,3-4,7,12,14H2,1-2H3
MMDB

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403288
PNG
(US10329307, Example 35)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@H]3CCCN(C3)c3ccc(Cl)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H25ClN4O4S/c1-32-19-10-22(34-15-16-4-3-9-30(13-16)18-7-5-17(27)6-8-18)20-12-24(35-23(20)11-19)21-14-31-25(28-21)36-26(29-31)33-2/h5-8,10-12,14,16H,3-4,9,13,15H2,1-2H3/t16-/m0/s1
MMDB

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403283
PNG
(US10329307, Example 30)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@H]3CCCN(C3)c3ccc(cc3)C#N)cc(OC)cc2o1
Show InChI InChI=1S/C27H25N5O4S/c1-33-20-10-23(35-16-18-4-3-9-31(14-18)19-7-5-17(13-28)6-8-19)21-12-25(36-24(21)11-20)22-15-32-26(29-22)37-27(30-32)34-2/h5-8,10-12,15,18H,3-4,9,14,16H2,1-2H3/t18-/m0/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403316
PNG
(US10329307, Example 63 | US10329307, Example 64 | ...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ccc(Cl)cn3)cc(OC)cc2o1
Show InChI InChI=1S/C25H24ClN5O4S/c1-32-17-8-20(34-14-15-4-3-7-30(12-15)23-6-5-16(26)11-27-23)18-10-22(35-21(18)9-17)19-13-31-24(28-19)36-25(29-31)33-2/h5-6,8-11,13,15H,3-4,7,12,14H2,1-2H3
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403284
PNG
(US10329307, Example 31)
Show SMILES CCOC(=O)c1ccc(cc1)N1CCC[C@H](COc2cc(OC)cc3oc(cc23)-c2cn3nc(OC)sc3n2)C1
Show InChI InChI=1S/C29H30N4O6S/c1-4-37-27(34)19-7-9-20(10-8-19)32-11-5-6-18(15-32)17-38-24-12-21(35-2)13-25-22(24)14-26(39-25)23-16-33-28(30-23)40-29(31-33)36-3/h7-10,12-14,16,18H,4-6,11,15,17H2,1-3H3/t18-/m0/s1
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403308
PNG
(US10329307, Example 55 | US10329307, Example 56 | ...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCCN3c3ccc(Cl)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H25ClN4O4S/c1-32-19-11-22(34-15-18-5-3-4-10-30(18)17-8-6-16(27)7-9-17)20-13-24(35-23(20)12-19)21-14-31-25(28-21)36-26(29-31)33-2/h6-9,11-14,18H,3-5,10,15H2,1-2H3
MMDB

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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403262
PNG
(US10329307, Example 9)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@H]3CCCN3c3ccc(Cl)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C25H23ClN4O4S/c1-31-18-10-21(33-14-17-4-3-9-29(17)16-7-5-15(26)6-8-16)19-12-23(34-22(19)11-18)20-13-30-24(27-20)35-25(28-30)32-2/h5-8,10-13,17H,3-4,9,14H2,1-2H3/t17-/m1/s1
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Universite de Montreal

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403282
PNG
(US10329307, Example 29)
Show SMILES CCOC(=O)c1ccc(cc1)N1CCC[C@@H](COc2cc(OC)cc3oc(cc23)-c2cn3nc(OC)sc3n2)C1
Show InChI InChI=1S/C29H30N4O6S/c1-4-37-27(34)19-7-9-20(10-8-19)32-11-5-6-18(15-32)17-38-24-12-21(35-2)13-25-22(24)14-26(39-25)23-16-33-28(30-23)40-29(31-33)36-3/h7-10,12-14,16,18H,4-6,11,15,17H2,1-3H3/t18-/m1/s1
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Universite de Montreal

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403277
PNG
(US10329307, Example 24)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCCN3c3ccc(C)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H26N4O4S/c1-16-6-8-17(9-7-16)29-10-4-5-18(29)15-33-22-11-19(31-2)12-23-20(22)13-24(34-23)21-14-30-25(27-21)35-26(28-30)32-3/h6-9,11-14,18H,4-5,10,15H2,1-3H3/t18-/m0/s1
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Universite de Montreal

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403300
PNG
(US10329307, Example 47)
Show SMILES CCOC(=O)c1ccc(cc1)N1CCC(COc2cc(OC)cc3oc(cc23)-c2cn3nc(OC)sc3n2)CC1
Show InChI InChI=1S/C29H30N4O6S/c1-4-37-27(34)19-5-7-20(8-6-19)32-11-9-18(10-12-32)17-38-24-13-21(35-2)14-25-22(24)15-26(39-25)23-16-33-28(30-23)40-29(31-33)36-3/h5-8,13-16,18H,4,9-12,17H2,1-3H3
MMDB

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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403316
PNG
(US10329307, Example 63 | US10329307, Example 64 | ...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ccc(Cl)cn3)cc(OC)cc2o1
Show InChI InChI=1S/C25H24ClN5O4S/c1-32-17-8-20(34-14-15-4-3-7-30(12-15)23-6-5-16(26)11-27-23)18-10-22(35-21(18)9-17)19-13-31-24(28-19)36-25(29-31)33-2/h5-6,8-11,13,15H,3-4,7,12,14H2,1-2H3
MMDB

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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403305
PNG
(US10329307, Example 52)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@H]3CCCN(C3)c3ccc(F)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H25FN4O4S/c1-32-19-10-22(34-15-16-4-3-9-30(13-16)18-7-5-17(27)6-8-18)20-12-24(35-23(20)11-19)21-14-31-25(28-21)36-26(29-31)33-2/h5-8,10-12,14,16H,3-4,9,13,15H2,1-2H3/t16-/m0/s1
MMDB

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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403295
PNG
(US10329307, Example 42)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ccc(OC)cc3OC)cc(OC)cc2o1
Show InChI InChI=1S/C28H30N4O6S/c1-33-18-7-8-22(26(10-18)35-3)31-9-5-6-17(14-31)16-37-23-11-19(34-2)12-24-20(23)13-25(38-24)21-15-32-27(29-21)39-28(30-32)36-4/h7-8,10-13,15,17H,5-6,9,14,16H2,1-4H3
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Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403301
PNG
(US10329307, Example 48)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCN(CC3)c3ccc(cc3)C#N)cc(OC)cc2o1
Show InChI InChI=1S/C27H25N5O4S/c1-33-20-11-23(35-16-18-7-9-31(10-8-18)19-5-3-17(14-28)4-6-19)21-13-25(36-24(21)12-20)22-15-32-26(29-22)37-27(30-32)34-2/h3-6,11-13,15,18H,7-10,16H2,1-2H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403256
PNG
(US10329307, Example 3)
Show SMILES COc1ccc(cc1)N1CCN(CC1COc1cc(OC)cc2oc(cc12)-c1cn2nc(C)ccc2n1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C33H37N5O6/c1-21-7-12-31-34-27(19-38(31)35-21)30-17-26-28(15-25(41-6)16-29(26)43-30)42-20-23-18-36(32(39)44-33(2,3)4)13-14-37(23)22-8-10-24(40-5)11-9-22/h7-12,15-17,19,23H,13-14,18,20H2,1-6H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403312
PNG
(US10329307, Example 59)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@H]3CCCN(C3)C(=O)OCc3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C28H28N4O6S/c1-34-20-11-23(21-13-25(38-24(21)12-20)22-15-32-26(29-22)39-27(30-32)35-2)36-17-19-9-6-10-31(14-19)28(33)37-16-18-7-4-3-5-8-18/h3-5,7-8,11-13,15,19H,6,9-10,14,16-17H2,1-2H3/t19-/m0/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403324
PNG
(US10329307, Example 71)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ccc(NC(=O)C(F)(F)F)nc3)cc(OC)cc2o1
Show InChI InChI=1S/C27H25F3N6O5S/c1-38-17-8-20(18-10-22(41-21(18)9-17)19-13-36-25(32-19)42-26(34-36)39-2)40-14-15-4-3-7-35(12-15)16-5-6-23(31-11-16)33-24(37)27(28,29)30/h5-6,8-11,13,15H,3-4,7,12,14H2,1-2H3,(H,31,33,37)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403268
PNG
(US10329307, Example 15)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCCN3c3ccc(Cl)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C25H23ClN4O4S/c1-31-18-10-21(33-14-17-4-3-9-29(17)16-7-5-15(26)6-8-16)19-12-23(34-22(19)11-18)20-13-30-24(27-20)35-25(28-30)32-2/h5-8,10-13,17H,3-4,9,14H2,1-2H3/t17-/m0/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403293
PNG
(US10329307, Example 40)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ccc(cc3)C#N)cc(OC)cc2o1
Show InChI InChI=1S/C27H25N5O4S/c1-33-20-10-23(35-16-18-4-3-9-31(14-18)19-7-5-17(13-28)6-8-19)21-12-25(36-24(21)11-20)22-15-32-26(29-22)37-27(30-32)34-2/h5-8,10-12,15,18H,3-4,9,14,16H2,1-2H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403319
PNG
(US10329307, Example 66)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ncc(Br)cn3)cc(OC)cc2o1
Show InChI InChI=1S/C24H23BrN6O4S/c1-32-16-6-19(34-13-14-4-3-5-30(11-14)22-26-9-15(25)10-27-22)17-8-21(35-20(17)7-16)18-12-31-23(28-18)36-24(29-31)33-2/h6-10,12,14H,3-5,11,13H2,1-2H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403311
PNG
(US10329307, Example 58)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@H]3CCCN(Cc4ccc(Cl)cc4)C3)cc(OC)cc2o1
Show InChI InChI=1S/C27H27ClN4O4S/c1-33-20-10-23(35-16-18-4-3-9-31(14-18)13-17-5-7-19(28)8-6-17)21-12-25(36-24(21)11-20)22-15-32-26(29-22)37-27(30-32)34-2/h5-8,10-12,15,18H,3-4,9,13-14,16H2,1-2H3/t18-/m0/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403325
PNG
(US10329307, Example 72)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCCN(C3)c3ccc(F)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H25FN4O4S/c1-32-19-10-22(34-15-16-4-3-9-30(13-16)18-7-5-17(27)6-8-18)20-12-24(35-23(20)11-19)21-14-31-25(28-21)36-26(29-31)33-2/h5-8,10-12,14,16H,3-4,9,13,15H2,1-2H3/t16-/m1/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403279
PNG
(US10329307, Example 26)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCN(C3)c3ccc(OC)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H26N4O5S/c1-31-18-6-4-17(5-7-18)29-9-8-16(13-29)15-34-22-10-19(32-2)11-23-20(22)12-24(35-23)21-14-30-25(27-21)36-26(28-30)33-3/h4-7,10-12,14,16H,8-9,13,15H2,1-3H3/t16-/m1/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403307
PNG
(US10329307, Example 54)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@H]3CCCN(C3)c3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H26N4O4S/c1-31-19-11-22(33-16-17-7-6-10-29(14-17)18-8-4-3-5-9-18)20-13-24(34-23(20)12-19)21-15-30-25(27-21)35-26(28-30)32-2/h3-5,8-9,11-13,15,17H,6-7,10,14,16H2,1-2H3/t17-/m0/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403261
PNG
(US10329307, Example 8)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)S(=O)(=O)c3ccc(C)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C27H28N4O6S2/c1-17-6-8-20(9-7-17)39(32,33)30-10-4-5-18(14-30)16-36-23-11-19(34-2)12-24-21(23)13-25(37-24)22-15-31-26(28-22)38-27(29-31)35-3/h6-9,11-13,15,18H,4-5,10,14,16H2,1-3H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403314
PNG
(US10329307, Example 61)
Show SMILES CCOC(=O)c1cnc(s1)N1CCCC(COc2cc(OC)cc3oc(cc23)-c2cn3nc(OC)sc3n2)C1
Show InChI InChI=1S/C26H27N5O6S2/c1-4-35-23(32)22-11-27-24(38-22)30-7-5-6-15(12-30)14-36-19-8-16(33-2)9-20-17(19)10-21(37-20)18-13-31-25(28-18)39-26(29-31)34-3/h8-11,13,15H,4-7,12,14H2,1-3H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403306
PNG
(US10329307, Example 53)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCCN(C3)c3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H26N4O4S/c1-31-19-11-22(33-16-17-7-6-10-29(14-17)18-8-4-3-5-9-18)20-13-24(34-23(20)12-19)21-15-30-25(27-21)35-26(28-30)32-2/h3-5,8-9,11-13,15,17H,6-7,10,14,16H2,1-2H3/t17-/m1/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403281
PNG
(US10329307, Example 28)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@@H]3CCCN(C3)c3ccc(cc3)C#N)cc(OC)cc2o1
Show InChI InChI=1S/C27H25N5O4S/c1-33-20-10-23(35-16-18-4-3-9-31(14-18)19-7-5-17(13-28)6-8-19)21-12-25(36-24(21)11-20)22-15-32-26(29-22)37-27(30-32)34-2/h5-8,10-12,15,18H,3-4,9,14,16H2,1-2H3/t18-/m1/s1
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403315
PNG
(US10329307, Example 62)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ncc(Br)s3)cc(OC)cc2o1
Show InChI InChI=1S/C23H22BrN5O4S2/c1-30-14-6-17(32-12-13-4-3-5-28(10-13)21-25-9-20(24)34-21)15-8-19(33-18(15)7-14)16-11-29-22(26-16)35-23(27-29)31-2/h6-9,11,13H,3-5,10,12H2,1-2H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403321
PNG
(US10329307, Example 68)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ccc(NC(=O)OC(C)(C)C)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C31H35N5O6S/c1-31(2,3)42-29(37)32-20-8-10-21(11-9-20)35-12-6-7-19(16-35)18-40-25-13-22(38-4)14-26-23(25)15-27(41-26)24-17-36-28(33-24)43-30(34-36)39-5/h8-11,13-15,17,19H,6-7,12,16,18H2,1-5H3,(H,32,37)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403294
PNG
(US10329307, Example 41)
Show SMILES CCOC(=O)c1ccc(cc1)N1CCCC(COc2cc(OC)cc3oc(cc23)-c2cn3nc(OC)sc3n2)C1
Show InChI InChI=1S/C29H30N4O6S/c1-4-37-27(34)19-7-9-20(10-8-19)32-11-5-6-18(15-32)17-38-24-12-21(35-2)13-25-22(24)14-26(39-25)23-16-33-28(30-23)40-29(31-33)36-3/h7-10,12-14,16,18H,4-6,11,15,17H2,1-3H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403280
PNG
(US10329307, Example 27)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CN(C3)c3ccc(F)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C24H21FN4O4S/c1-30-17-7-20(32-13-14-10-28(11-14)16-5-3-15(25)4-6-16)18-9-22(33-21(18)8-17)19-12-29-23(26-19)34-24(27-29)31-2/h3-9,12,14H,10-11,13H2,1-2H3
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US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403313
PNG
(US10329307, Example 60)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3nncs3)cc(OC)cc2o1
Show InChI InChI=1S/C22H22N6O4S2/c1-29-14-6-17(31-11-13-4-3-5-27(9-13)21-25-23-12-33-21)15-8-19(32-18(15)7-14)16-10-28-20(24-16)34-22(26-28)30-2/h6-8,10,12-13H,3-5,9,11H2,1-2H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403302
PNG
(US10329307, Example 49)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCN(CC3)c3ccc(Cl)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H25ClN4O4S/c1-32-19-11-22(34-15-16-7-9-30(10-8-16)18-5-3-17(27)4-6-18)20-13-24(35-23(20)12-19)21-14-31-25(28-21)36-26(29-31)33-2/h3-6,11-14,16H,7-10,15H2,1-2H3
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n/an/a 2.70E+3n/an/an/an/an/an/a



Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403285
PNG
(US10329307, Example 32)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ccc(OC)cn3)cc(OC)cc2o1
Show InChI InChI=1S/C26H27N5O5S/c1-32-17-6-7-24(27-12-17)30-8-4-5-16(13-30)15-35-21-9-18(33-2)10-22-19(21)11-23(36-22)20-14-31-25(28-20)37-26(29-31)34-3/h6-7,9-12,14,16H,4-5,8,13,15H2,1-3H3
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n/an/a 2.80E+3n/an/an/an/an/an/a



Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403322
PNG
(US10329307, Example 69)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ccc(NC(=O)OC(C)(C)C)nc3)cc(OC)cc2o1
Show InChI InChI=1S/C30H34N6O6S/c1-30(2,3)42-28(37)33-26-9-8-19(14-31-26)35-10-6-7-18(15-35)17-40-23-11-20(38-4)12-24-21(23)13-25(41-24)22-16-36-27(32-22)43-29(34-36)39-5/h8-9,11-14,16,18H,6-7,10,15,17H2,1-5H3,(H,31,33,37)
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403320
PNG
(US10329307, Example 67)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCC(=O)N(C3)c3ccc(Cl)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H23ClN4O5S/c1-33-18-9-21(35-14-15-3-8-24(32)30(12-15)17-6-4-16(27)5-7-17)19-11-23(36-22(19)10-18)20-13-31-25(28-20)37-26(29-31)34-2/h4-7,9-11,13,15H,3,8,12,14H2,1-2H3
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n/an/a 3.30E+3n/an/an/an/an/an/a



Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403323
PNG
(US10329307, Example 70)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ccc(OCc4ccc(OC)cc4)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C34H34N4O6S/c1-39-25-10-6-22(7-11-25)20-42-26-12-8-24(9-13-26)37-14-4-5-23(18-37)21-43-30-15-27(40-2)16-31-28(30)17-32(44-31)29-19-38-33(35-29)45-34(36-38)41-3/h6-13,15-17,19,23H,4-5,14,18,20-21H2,1-3H3
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n/an/a 3.50E+3n/an/an/an/an/an/a



Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403303
PNG
(US10329307, Example 50)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCN(CC3)c3ccc(F)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H25FN4O4S/c1-32-19-11-22(34-15-16-7-9-30(10-8-16)18-5-3-17(27)4-6-18)20-13-24(35-23(20)12-19)21-14-31-25(28-21)36-26(29-31)33-2/h3-6,11-14,16H,7-10,15H2,1-2H3
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n/an/a 4.80E+3n/an/an/an/an/an/a



Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403304
PNG
(US10329307, Example 51)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCN(CC3)c3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H26N4O4S/c1-31-19-12-22(33-16-17-8-10-29(11-9-17)18-6-4-3-5-7-18)20-14-24(34-23(20)13-19)21-15-30-25(27-21)35-26(28-30)32-2/h3-7,12-15,17H,8-11,16H2,1-2H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403255
PNG
(US10329307, Example 2)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@H]3CCCN3C3CCOCC3)cc(OC)cc2o1
Show InChI InChI=1S/C24H28N4O5S/c1-29-17-10-20(32-14-16-4-3-7-27(16)15-5-8-31-9-6-15)18-12-22(33-21(18)11-17)19-13-28-23(25-19)34-24(26-28)30-2/h10-13,15-16H,3-9,14H2,1-2H3/t16-/m1/s1
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n/an/a 9.40E+3n/an/an/an/an/an/a



Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403267
PNG
(US10329307, Example 14)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OC[C@H]3CCC(=O)N3c3ccc(F)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C25H21FN4O5S/c1-32-17-9-20(34-13-16-7-8-23(31)30(16)15-5-3-14(26)4-6-15)18-11-22(35-21(18)10-17)19-12-29-24(27-19)36-25(28-29)33-2/h3-6,9-12,16H,7-8,13H2,1-2H3/t16-/m1/s1
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n/an/a 1.20E+4n/an/an/an/an/an/a



Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403259
PNG
(US10329307, Example 6)
Show SMILES COc1ccc(cc1)N1CCN(CC1COc1cc(OC)cc2oc(cc12)-c1cn2nc(C)ccc2n1)C(=O)C1CC1
Show InChI InChI=1S/C32H33N5O5/c1-20-4-11-31-33-27(18-37(31)34-20)30-16-26-28(14-25(40-3)15-29(26)42-30)41-19-23-17-35(32(38)21-5-6-21)12-13-36(23)22-7-9-24(39-2)10-8-22/h4,7-11,14-16,18,21,23H,5-6,12-13,17,19H2,1-3H3
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n/an/a 1.50E+4n/an/an/an/an/an/a



Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403260
PNG
(US10329307, Example 7)
Show SMILES COc1ccc(cc1)N1CCN(CC2CC2)CC1COc1cc(OC)cc2oc(cc12)-c1cn2nc(C)ccc2n1
Show InChI InChI=1S/C32H35N5O4/c1-21-4-11-32-33-28(19-37(32)34-21)31-16-27-29(14-26(39-3)15-30(27)41-31)40-20-24-18-35(17-22-5-6-22)12-13-36(24)23-7-9-25(38-2)10-8-23/h4,7-11,14-16,19,22,24H,5-6,12-13,17-18,20H2,1-3H3
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n/an/a 1.60E+4n/an/an/an/an/an/a



Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403258
PNG
(US10329307, Example 5)
Show SMILES COc1ccc(cc1)N1CCN(CC1COc1cc(OC)cc2oc(cc12)-c1cn2nc(C)ccc2n1)C(=O)c1ccccc1
Show InChI InChI=1S/C35H33N5O5/c1-23-9-14-34-36-30(21-40(34)37-23)33-19-29-31(17-28(43-3)18-32(29)45-33)44-22-26-20-38(35(41)24-7-5-4-6-8-24)15-16-39(26)25-10-12-27(42-2)13-11-25/h4-14,17-19,21,26H,15-16,20,22H2,1-3H3
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n/an/a 2.40E+4n/an/an/an/an/an/a



Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403327
PNG
(US10329307, Example 74)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)c3ccc(N)nc3)cc(OC)cc2o1
Show InChI InChI=1S/C25H26N6O4S/c1-32-17-8-20(34-14-15-4-3-7-30(12-15)16-5-6-23(26)27-11-16)18-10-22(35-21(18)9-17)19-13-31-24(28-19)36-25(29-31)33-2/h5-6,8-11,13,15H,3-4,7,12,14H2,1-2H3,(H2,26,27)
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n/an/a 2.80E+4n/an/an/an/an/an/a



Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403326
PNG
(US10329307, Example 73)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCC3CCCN(C3)C3CCOCC3)cc(OC)cc2o1
Show InChI InChI=1S/C25H30N4O5S/c1-30-18-10-21(33-15-16-4-3-7-28(13-16)17-5-8-32-9-6-17)19-12-23(34-22(19)11-18)20-14-29-24(26-20)35-25(27-29)31-2/h10-12,14,16-17H,3-9,13,15H2,1-2H3
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Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
PRKC apoptosis WT1 regulator protein


(Homo sapiens (Human))
BDBM403257
PNG
(US10329307, Example 4)
Show SMILES COc1ccc(cc1)N1CCNCC1COc1cc(OC)cc2oc(cc12)-c1cn2nc(C)ccc2n1
Show InChI InChI=1S/C28H29N5O4/c1-18-4-9-28-30-24(16-33(28)31-18)27-14-23-25(12-22(35-3)13-26(23)37-27)36-17-20-15-29-10-11-32(20)19-5-7-21(34-2)8-6-19/h4-9,12-14,16,20,29H,10-11,15,17H2,1-3H3
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n/an/a 4.60E+5n/an/an/an/an/an/a



Universite de Montreal

US Patent


Assay Description
FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism, agonism, and selectivity against PAR1. The activity of th...


US Patent US10329307 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%