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Patent code US10335399

Compile Data Set for Download or QSAR
Found 59 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403460
PNG
(US10335399, Example 2-5)
Show SMILES CC1(C)CCc2c(O1)nc(cc2-c1ccc(F)cc1F)C(N)=O
Show InChI InChI=1S/C17H16F2N2O2/c1-17(2)6-5-11-12(10-4-3-9(18)7-13(10)19)8-14(15(20)22)21-16(11)23-17/h3-4,7-8H,5-6H2,1-2H3,(H2,20,22)
PDB

UniProtKB/SwissProt

GoogleScholar
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PC sid
UniChem
US Patent
n/an/a 6n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403486
PNG
(US10335399, Example 3-9A)
Show SMILES C[C@@H]1Cc2c(O[C@@H]1COC(F)F)nc(cc2-c1ccc(F)cc1F)C(N)=O
Show InChI InChI=1S/C18H16F4N2O3/c1-8-4-12-11(10-3-2-9(19)5-13(10)20)6-14(16(23)25)24-17(12)27-15(8)7-26-18(21)22/h2-3,5-6,8,15,18H,4,7H2,1H3,(H2,23,25)/t8-,15-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403470
PNG
(US10335399, Example 3-1A)
Show SMILES NC(=O)c1cc(c2CC[C@H](COC(F)F)Oc2n1)-c1ccc(F)cc1F
Show InChI InChI=1S/C17H14F4N2O3/c18-8-1-3-10(13(19)5-8)12-6-14(15(22)24)23-16-11(12)4-2-9(26-16)7-25-17(20)21/h1,3,5-6,9,17H,2,4,7H2,(H2,22,24)/t9-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403464
PNG
(US10335399, Example 2-8A)
Show SMILES C[C@]1(COC(F)F)CCc2c(O1)nc(cc2-c1ccc(F)cc1F)C(N)=O
Show InChI InChI=1S/C18H16F4N2O3/c1-18(8-26-17(21)22)5-4-11-12(10-3-2-9(19)6-13(10)20)7-14(15(23)25)24-16(11)27-18/h2-3,6-7,17H,4-5,8H2,1H3,(H2,23,25)/t18-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403489
PNG
(US10335399, Example 3-9D)
Show SMILES C[C@H]1Cc2c(O[C@H]1COC(F)F)nc(cc2-c1ccc(F)cc1F)C(N)=O
Show InChI InChI=1S/C18H16F4N2O3/c1-8-4-12-11(10-3-2-9(19)5-13(10)20)6-14(16(23)25)24-17(12)27-15(8)7-26-18(21)22/h2-3,5-6,8,15,18H,4,7H2,1H3,(H2,23,25)/t8-,15-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 9n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403461
PNG
(US10335399, Example 2-6A)
Show SMILES C[C@H]1CCc2c(O1)nc(cc2-c1ccc(F)cc1F)C(N)=O
Show InChI InChI=1S/C16H14F2N2O2/c1-8-2-4-11-12(10-5-3-9(17)6-13(10)18)7-14(15(19)21)20-16(11)22-8/h3,5-8H,2,4H2,1H3,(H2,19,21)/t8-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403481
PNG
(US10335399, Example 3-6B)
Show SMILES NC(=O)c1cc(c2CC[C@@H](CF)Oc2n1)-c1ccc(F)cc1F
Show InChI InChI=1S/C16H13F3N2O2/c17-7-9-2-4-11-12(10-3-1-8(18)5-13(10)19)6-14(15(20)22)21-16(11)23-9/h1,3,5-6,9H,2,4,7H2,(H2,20,22)/t9-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403468
PNG
(US10335399, Example 2-9C)
Show SMILES C[C@H](OC(F)F)[C@H]1CCc2c(O1)nc(cc2-c1ccc(F)cc1F)C(N)=O
Show InChI InChI=1S/C18H16F4N2O3/c1-8(26-18(21)22)15-5-4-11-12(10-3-2-9(19)6-13(10)20)7-14(16(23)25)24-17(11)27-15/h2-3,6-8,15,18H,4-5H2,1H3,(H2,23,25)/t8-,15+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 11n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403441
PNG
((6R,9S)- or (6S,9R)- 4-(4-chloro-2- fluorophenyl)-...)
Show SMILES NC(=O)c1cc(c2[C@@H]3CC[C@@H](O3)c2n1)-c1ccc(Cl)cc1F
Show InChI InChI=1S/C16H12ClFN2O2/c17-7-1-2-8(10(18)5-7)9-6-11(16(19)21)20-15-13-4-3-12(22-13)14(9)15/h1-2,5-6,12-13H,3-4H2,(H2,19,21)/t12-,13+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 12n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403484
PNG
(US10335399, Example 3-8A)
Show SMILES NC(=O)c1cc(c2CC[C@H](CC(F)(F)F)Oc2n1)-c1ccc(F)cc1F
Show InChI InChI=1S/C17H13F5N2O2/c18-8-1-3-10(13(19)5-8)12-6-14(15(23)25)24-16-11(12)4-2-9(26-16)7-17(20,21)22/h1,3,5-6,9H,2,4,7H2,(H2,23,25)/t9-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 12n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403465
PNG
(US10335399, Example 2-8B)
Show SMILES C[C@@]1(COC(F)F)CCc2c(O1)nc(cc2-c1ccc(F)cc1F)C(N)=O
Show InChI InChI=1S/C18H16F4N2O3/c1-18(8-26-17(21)22)5-4-11-12(10-3-2-9(19)6-13(10)20)7-14(15(23)25)24-16(11)27-18/h2-3,6-7,17H,4-5,8H2,1H3,(H2,23,25)/t18-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 14n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403488
PNG
(US10335399, Example 3-9C)
Show SMILES C[C@@H]1Cc2c(O[C@H]1COC(F)F)nc(cc2-c1ccc(F)cc1F)C(N)=O
Show InChI InChI=1S/C18H16F4N2O3/c1-8-4-12-11(10-3-2-9(19)5-13(10)20)6-14(16(23)25)24-17(12)27-15(8)7-26-18(21)22/h2-3,5-6,8,15,18H,4,7H2,1H3,(H2,23,25)/t8-,15+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 15n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403453
PNG
(US10335399, Example 2-2B)
Show SMILES C[C@H]1Cc2c(O[C@@H]1CO)nc(cc2-c1ccc(F)cc1F)C(N)=O
Show InChI InChI=1S/C17H16F2N2O3/c1-8-4-12-11(10-3-2-9(18)5-13(10)19)6-14(16(20)23)21-17(12)24-15(8)7-22/h2-3,5-6,8,15,22H,4,7H2,1H3,(H2,20,23)/t8-,15+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 15n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403466
PNG
(US10335399, Example 2-9A)
Show SMILES C[C@H](OC(F)F)[C@@H]1CCc2c(O1)nc(cc2-c1ccc(F)cc1F)C(N)=O
Show InChI InChI=1S/C18H16F4N2O3/c1-8(26-18(21)22)15-5-4-11-12(10-3-2-9(19)6-13(10)20)7-14(16(23)25)24-17(11)27-15/h2-3,6-8,15,18H,4-5H2,1H3,(H2,23,25)/t8-,15-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 18n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403472
PNG
((S)- or (R)-2- ((difluoro- methoxy)methyl)- 5-(4- ...)
Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)c2CC[C@H](COC(F)F)Oc2n1
Show InChI InChI=1S/C17H15F3N2O3/c18-10-3-1-9(2-4-10)13-7-14(15(21)23)22-16-12(13)6-5-11(25-16)8-24-17(19)20/h1-4,7,11,17H,5-6,8H2,(H2,21,23)/t11-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 18n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403482
PNG
(US10335399, Example 3-7A)
Show SMILES NC(=O)c1cc(c2CC[C@@H](Oc2n1)C(F)F)-c1ccc(F)cc1F
Show InChI InChI=1S/C16H12F4N2O2/c17-7-1-2-8(11(18)5-7)10-6-12(15(21)23)22-16-9(10)3-4-13(24-16)14(19)20/h1-2,5-6,13-14H,3-4H2,(H2,21,23)/t13-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 18n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403487
PNG
(US10335399, Example 3-9B)
Show SMILES C[C@H]1Cc2c(O[C@@H]1COC(F)F)nc(cc2-c1ccc(F)cc1F)C(N)=O
Show InChI InChI=1S/C18H16F4N2O3/c1-8-4-12-11(10-3-2-9(19)5-13(10)20)6-14(16(23)25)24-17(12)27-15(8)7-26-18(21)22/h2-3,5-6,8,15,18H,4,7H2,1H3,(H2,23,25)/t8-,15+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 19n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403471
PNG
(US10335399, Example 3-1B)
Show SMILES NC(=O)c1cc(c2CC[C@@H](COC(F)F)Oc2n1)-c1ccc(F)cc1F
Show InChI InChI=1S/C17H14F4N2O3/c18-8-1-3-10(13(19)5-8)12-6-14(15(22)24)23-16-11(12)4-2-9(26-16)7-25-17(20)21/h1,3,5-6,9,17H,2,4,7H2,(H2,22,24)/t9-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 19n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403458
PNG
(US10335399, Example 2-4A)
Show SMILES CC(C)[C@H]1CCc2c(O1)nc(cc2-c1ccc(F)cc1F)C(N)=O
Show InChI InChI=1S/C18H18F2N2O2/c1-9(2)16-6-5-12-13(11-4-3-10(19)7-14(11)20)8-15(17(21)23)22-18(12)24-16/h3-4,7-9,16H,5-6H2,1-2H3,(H2,21,23)/t16-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403456
PNG
(US10335399, Example 2-3A)
Show SMILES NC(=O)c1cc(c2CC[C@@H](Oc2n1)C1CC1)-c1ccc(F)cc1F
Show InChI InChI=1S/C18H16F2N2O2/c19-10-3-4-11(14(20)7-10)13-8-15(17(21)23)22-18-12(13)5-6-16(24-18)9-1-2-9/h3-4,7-9,16H,1-2,5-6H2,(H2,21,23)/t16-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403439
PNG
(US10335399, Example 1-2B)
Show SMILES NC(=O)c1cc(c2C[C@H]3CC[C@H](O3)c2n1)-c1ccc(F)cc1F
Show InChI InChI=1S/C17H14F2N2O2/c18-8-1-3-10(13(19)5-8)11-7-14(17(20)22)21-16-12(11)6-9-2-4-15(16)23-9/h1,3,5,7,9,15H,2,4,6H2,(H2,20,22)/t9-,15+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 21n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403492
PNG
(US10335399, Example 4-2A)
Show SMILES NC(=O)c1cc(c2CC[C@H](CNCC(F)(F)F)Oc2n1)-c1ccc(F)cc1F
Show InChI InChI=1S/C18H16F5N3O2/c19-9-1-3-11(14(20)5-9)13-6-15(16(24)27)26-17-12(13)4-2-10(28-17)7-25-8-18(21,22)23/h1,3,5-6,10,25H,2,4,7-8H2,(H2,24,27)/t10-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 21n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403485
PNG
(US10335399, Example 3-8B)
Show SMILES NC(=O)c1cc(c2CC[C@@H](CC(F)(F)F)Oc2n1)-c1ccc(F)cc1F
Show InChI InChI=1S/C17H13F5N2O2/c18-8-1-3-10(13(19)5-8)12-6-14(15(23)25)24-16-11(12)4-2-9(26-16)7-17(20,21)22/h1,3,5-6,9H,2,4,7H2,(H2,23,25)/t9-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 24n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403490
PNG
(US10335399, Example 4-1A)
Show SMILES CN(C[C@H]1CCc2c(O1)nc(cc2-c1ccc(F)cc1F)C(N)=O)CC(F)(F)F
Show InChI InChI=1S/C19H18F5N3O2/c1-27(9-19(22,23)24)8-11-3-5-13-14(12-4-2-10(20)6-15(12)21)7-16(17(25)28)26-18(13)29-11/h2,4,6-7,11H,3,5,8-9H2,1H3,(H2,25,28)/t11-/m1/s1
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Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403463
PNG
(US10335399, Example 2-7)
Show SMILES CC1(C)COc2nc(cc(c2C1)-c1ccc(F)cc1F)C(N)=O
Show InChI InChI=1S/C17H16F2N2O2/c1-17(2)7-12-11(10-4-3-9(18)5-13(10)19)6-14(15(20)22)21-16(12)23-8-17/h3-6H,7-8H2,1-2H3,(H2,20,22)
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Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403462
PNG
(US10335399, Example 2-6B)
Show SMILES C[C@@H]1CCc2c(O1)nc(cc2-c1ccc(F)cc1F)C(N)=O
Show InChI InChI=1S/C16H14F2N2O2/c1-8-2-4-11-12(10-5-3-9(17)6-13(10)18)7-14(15(19)21)20-16(11)22-8/h3,5-8H,2,4H2,1H3,(H2,19,21)/t8-/m1/s1
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Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403478
PNG
(US10335399, Example 3-5A)
Show SMILES COC[C@H]1CCc2c(O1)nc(cc2-c1ccc(F)cc1F)C(N)=O
Show InChI InChI=1S/C17H16F2N2O3/c1-23-8-10-3-5-12-13(11-4-2-9(18)6-14(11)19)7-15(16(20)22)21-17(12)24-10/h2,4,6-7,10H,3,5,8H2,1H3,(H2,20,22)/t10-/m1/s1
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Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403479
PNG
(US10335399, Example 3-5B)
Show SMILES COC[C@@H]1CCc2c(O1)nc(cc2-c1ccc(F)cc1F)C(N)=O
Show InChI InChI=1S/C17H16F2N2O3/c1-23-8-10-3-5-12-13(11-4-2-9(18)6-14(11)19)7-15(16(20)22)21-17(12)24-10/h2,4,6-7,10H,3,5,8H2,1H3,(H2,20,22)/t10-/m0/s1
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Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403493
PNG
(US10335399, Example 4-2B)
Show SMILES NC(=O)c1cc(c2CC[C@@H](CNCC(F)(F)F)Oc2n1)-c1ccc(F)cc1F
Show InChI InChI=1S/C18H16F5N3O2/c19-9-1-3-11(14(20)5-9)13-6-15(16(24)27)26-17-12(13)4-2-10(28-17)7-25-8-18(21,22)23/h1,3,5-6,10,25H,2,4,7-8H2,(H2,24,27)/t10-/m0/s1
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Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403457
PNG
(US10335399, Example 2-3B)
Show SMILES NC(=O)c1cc(c2CC[C@H](Oc2n1)C1CC1)-c1ccc(F)cc1F
Show InChI InChI=1S/C18H16F2N2O2/c19-10-3-4-11(14(20)7-10)13-8-15(17(21)23)22-18-12(13)5-6-16(24-18)9-1-2-9/h3-4,7-9,16H,1-2,5-6H2,(H2,21,23)/t16-/m0/s1
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Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403454
PNG
(US10335399, Example 2-2C)
Show SMILES C[C@@H]1Cc2c(O[C@H]1CO)nc(cc2-c1ccc(F)cc1F)C(N)=O
Show InChI InChI=1S/C17H16F2N2O3/c1-8-4-12-11(10-3-2-9(18)5-13(10)19)6-14(16(20)23)21-17(12)24-15(8)7-22/h2-3,5-6,8,15,22H,4,7H2,1H3,(H2,20,23)/t8-,15+/m1/s1
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US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403450
PNG
(US10335399, Example 2-1A)
Show SMILES NC(=O)c1cc(c2CC[C@@H](CO)Oc2n1)-c1ccc(F)cc1F
Show InChI InChI=1S/C16H14F2N2O3/c17-8-1-3-10(13(18)5-8)12-6-14(15(19)22)20-16-11(12)4-2-9(7-21)23-16/h1,3,5-6,9,21H,2,4,7H2,(H2,19,22)/t9-/m0/s1
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US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403480
PNG
(US10335399, Example 3-6A)
Show SMILES NC(=O)c1cc(c2CC[C@H](CF)Oc2n1)-c1ccc(F)cc1F
Show InChI InChI=1S/C16H13F3N2O2/c17-7-9-2-4-11-12(10-3-1-8(18)5-13(10)19)6-14(15(20)22)21-16(11)23-9/h1,3,5-6,9H,2,4,7H2,(H2,20,22)/t9-/m1/s1
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Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403469
PNG
(US10335399, Example 2-9D)
Show SMILES C[C@@H](OC(F)F)[C@H]1CCc2c(O1)nc(cc2-c1ccc(F)cc1F)C(N)=O
Show InChI InChI=1S/C18H16F4N2O3/c1-8(26-18(21)22)15-5-4-11-12(10-3-2-9(19)6-13(10)20)7-14(16(23)25)24-17(11)27-15/h2-3,6-8,15,18H,4-5H2,1H3,(H2,23,25)/t8-,15-/m1/s1
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US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403440
PNG
((6S,9R)- or (6R,9S)- 4-(4-chloro-2- fluorophenyl)-...)
Show SMILES NC(=O)c1cc(c2[C@H]3CC[C@H](O3)c2n1)-c1ccc(Cl)cc1F
Show InChI InChI=1S/C16H12ClFN2O2/c17-7-1-2-8(10(18)5-7)9-6-11(16(19)21)20-15-13-4-3-12(22-13)14(9)15/h1-2,5-6,12-13H,3-4H2,(H2,19,21)/t12-,13+/m1/s1
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US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403459
PNG
(US10335399, Example 2-4B)
Show SMILES CC(C)[C@@H]1CCc2c(O1)nc(cc2-c1ccc(F)cc1F)C(N)=O
Show InChI InChI=1S/C18H18F2N2O2/c1-9(2)16-6-5-12-13(11-4-3-10(19)7-14(11)20)8-15(17(21)23)22-18(12)24-16/h3-4,7-9,16H,5-6H2,1-2H3,(H2,21,23)/t16-/m0/s1
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Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403491
PNG
(US10335399, Example 4-1B)
Show SMILES CN(C[C@@H]1CCc2c(O1)nc(cc2-c1ccc(F)cc1F)C(N)=O)CC(F)(F)F
Show InChI InChI=1S/C19H18F5N3O2/c1-27(9-19(22,23)24)8-11-3-5-13-14(12-4-2-10(20)6-15(12)21)7-16(17(25)28)26-18(13)29-11/h2,4,6-7,11H,3,5,8-9H2,1H3,(H2,25,28)/t11-/m0/s1
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Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403455
PNG
(US10335399, Example 2-2D)
Show SMILES C[C@H]1Cc2c(O[C@H]1CO)nc(cc2-c1ccc(F)cc1F)C(N)=O
Show InChI InChI=1S/C17H16F2N2O3/c1-8-4-12-11(10-3-2-9(18)5-13(10)19)6-14(16(20)23)21-17(12)24-15(8)7-22/h2-3,5-6,8,15,22H,4,7H2,1H3,(H2,20,23)/t8-,15-/m0/s1
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Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403473
PNG
((R)- or (S)-2- ((difluoro- methoxy)methyl)- 5-(4- ...)
Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)c2CC[C@@H](COC(F)F)Oc2n1
Show InChI InChI=1S/C17H15F3N2O3/c18-10-3-1-9(2-4-10)13-7-14(15(21)23)22-16-12(13)6-5-11(25-16)8-24-17(19)20/h1-4,7,11,17H,5-6,8H2,(H2,21,23)/t11-/m0/s1
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US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403483
PNG
(US10335399, Example 3-7B)
Show SMILES NC(=O)c1cc(c2CC[C@H](Oc2n1)C(F)F)-c1ccc(F)cc1F
Show InChI InChI=1S/C16H12F4N2O2/c17-7-1-2-8(11(18)5-7)10-6-12(15(21)23)22-16-9(10)3-4-13(24-16)14(19)20/h1-2,5-6,13-14H,3-4H2,(H2,21,23)/t13-/m0/s1
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US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403467
PNG
(US10335399, Example 2-9B)
Show SMILES C[C@@H](OC(F)F)[C@@H]1CCc2c(O1)nc(cc2-c1ccc(F)cc1F)C(N)=O
Show InChI InChI=1S/C18H16F4N2O3/c1-8(26-18(21)22)15-5-4-11-12(10-3-2-9(19)6-13(10)20)7-14(16(23)25)24-17(11)27-15/h2-3,6-8,15,18H,4-5H2,1H3,(H2,23,25)/t8-,15+/m1/s1
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US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403494
PNG
(US10335399, Example 5-1A)
Show SMILES NC(=O)c1cc(c2[C@H]3CC[C@H](O3)c2n1)-c1ccc(F)cc1F
Show InChI InChI=1S/C16H12F2N2O2/c17-7-1-2-8(10(18)5-7)9-6-11(16(19)21)20-15-13-4-3-12(22-13)14(9)15/h1-2,5-6,12-13H,3-4H2,(H2,19,21)/t12-,13+/m1/s1
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US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403449
PNG
(US10335399, Example 1-7B)
Show SMILES NC(=O)c1cc(c2C[C@@H]3CC[C@@H](O3)c2n1)-c1ncc(Cl)cc1F
Show InChI InChI=1S/C16H13ClFN3O2/c17-7-3-11(18)14(20-6-7)10-5-12(16(19)22)21-15-9(10)4-8-1-2-13(15)23-8/h3,5-6,8,13H,1-2,4H2,(H2,19,22)/t8-,13+/m0/s1
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US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403451
PNG
(US10335399, Example 2-1B)
Show SMILES NC(=O)c1cc(c2CC[C@H](CO)Oc2n1)-c1ccc(F)cc1F
Show InChI InChI=1S/C16H14F2N2O3/c17-8-1-3-10(13(18)5-8)12-6-14(15(19)22)20-16-11(12)4-2-9(7-21)23-16/h1,3,5-6,9,21H,2,4,7H2,(H2,19,22)/t9-/m1/s1
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US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403452
PNG
(US10335399, Example 2-2A)
Show SMILES C[C@@H]1Cc2c(O[C@@H]1CO)nc(cc2-c1ccc(F)cc1F)C(N)=O
Show InChI InChI=1S/C17H16F2N2O3/c1-8-4-12-11(10-3-2-9(18)5-13(10)19)6-14(16(20)23)21-17(12)24-15(8)7-22/h2-3,5-6,8,15,22H,4,7H2,1H3,(H2,20,23)/t8-,15-/m1/s1
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US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403476
PNG
((S)- or (R)-2- ((difluoro- methoxy)methyl)- 5-(1- ...)
Show SMILES NC(=O)c1cc(-c2cnn(c2)C(F)F)c2CC[C@H](COC(F)F)Oc2n1
Show InChI InChI=1S/C15H14F4N4O3/c16-14(17)23-5-7(4-21-23)10-3-11(12(20)24)22-13-9(10)2-1-8(26-13)6-25-15(18)19/h3-5,8,14-15H,1-2,6H2,(H2,20,24)/t8-/m1/s1
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US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403437
PNG
(US10335399, Example 1-1)
Show SMILES NC(=O)c1cc(c2CCOCc2n1)-c1ccc(F)cc1F
Show InChI InChI=1S/C15H12F2N2O2/c16-8-1-2-9(12(17)5-8)11-6-13(15(18)20)19-14-7-21-4-3-10(11)14/h1-2,5-6H,3-4,7H2,(H2,18,20)
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US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403445
PNG
((6S,9R)- or (6R,9S)- 4-(1- (difluoromethyl)- 1H-py...)
Show SMILES NC(=O)c1cc(-c2cnn(c2)C(F)F)c2C[C@@H]3CC[C@@H](O3)c2n1
Show InChI InChI=1S/C15H14F2N4O2/c16-15(17)21-6-7(5-19-21)9-4-11(14(18)22)20-13-10(9)3-8-1-2-12(13)23-8/h4-6,8,12,15H,1-3H2,(H2,18,22)/t8-,12+/m0/s1
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n/an/a 326n/an/an/an/an/an/a



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US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403438
PNG
(US10335399, Example 1-2A)
Show SMILES NC(=O)c1cc(c2C[C@@H]3CC[C@@H](O3)c2n1)-c1ccc(F)cc1F
Show InChI InChI=1S/C17H14F2N2O2/c18-8-1-3-10(13(19)5-8)11-7-14(17(20)22)21-16-12(11)6-9-2-4-15(16)23-9/h1,3,5,7,9,15H,2,4,6H2,(H2,20,22)/t9-,15+/m0/s1
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n/an/a 376n/an/an/an/an/an/a



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US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403495
PNG
(US10335399, Example 5-1B)
Show SMILES NC(=O)c1cc(c2[C@@H]3CC[C@@H](O3)c2n1)-c1ccc(F)cc1F
Show InChI InChI=1S/C16H12F2N2O2/c17-7-1-2-8(10(18)5-7)9-6-11(16(19)21)20-15-13-4-3-12(22-13)14(9)15/h1-2,5-6,12-13H,3-4H2,(H2,19,21)/t12-,13+/m0/s1
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n/an/a 500n/an/an/an/an/an/a



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US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403474
PNG
((S)- or (R)-2- ((difluoro- methoxy)methyl)- 5-(2- ...)
Show SMILES Cc1ncc(s1)-c1cc(nc2O[C@@H](COC(F)F)CCc12)C(N)=O
Show InChI InChI=1S/C15H15F2N3O3S/c1-7-19-5-12(24-7)10-4-11(13(18)21)20-14-9(10)3-2-8(23-14)6-22-15(16)17/h4-5,8,15H,2-3,6H2,1H3,(H2,18,21)/t8-/m1/s1
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n/an/a 536n/an/an/an/an/an/a



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US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403477
PNG
((R)- or (S)-2- ((difluoro- methoxy)methyl)- 5-(1- ...)
Show SMILES NC(=O)c1cc(-c2cnn(c2)C(F)F)c2CC[C@@H](COC(F)F)Oc2n1
Show InChI InChI=1S/C15H14F4N4O3/c16-14(17)23-5-7(4-21-23)10-3-11(12(20)24)22-13-9(10)2-1-8(26-13)6-25-15(18)19/h3-5,8,14-15H,1-2,6H2,(H2,20,24)/t8-/m0/s1
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n/an/a 1.49E+3n/an/an/an/an/an/a



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US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403443
PNG
((6S,9R)- or (6R,9S)- 4-(1-methyl-1H- pyrazol-4-yl)...)
Show SMILES Cn1cc(cn1)-c1cc(nc2[C@H]3CC[C@@H](Cc12)O3)C(N)=O
Show InChI InChI=1S/C15H16N4O2/c1-19-7-8(6-17-19)10-5-12(15(16)20)18-14-11(10)4-9-2-3-13(14)21-9/h5-7,9,13H,2-4H2,1H3,(H2,16,20)/t9-,13+/m0/s1
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n/an/a 1.77E+3n/an/an/an/an/an/a



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US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403447
PNG
(US10335399, Example 1-6B)
Show SMILES NC(=O)c1cc(c2C[C@@H]3CC[C@@H](O3)c2n1)-c1ncc(F)cc1F
Show InChI InChI=1S/C16H13F2N3O2/c17-7-3-11(18)14(20-6-7)10-5-12(16(19)22)21-15-9(10)4-8-1-2-13(15)23-8/h3,5-6,8,13H,1-2,4H2,(H2,19,22)/t8-,13+/m0/s1
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n/an/a 1.80E+3n/an/an/an/an/an/a



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US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403475
PNG
((R)- or (S)-2- ((difluoro- methoxy)methyl)- 5-(2- ...)
Show SMILES Cc1ncc(s1)-c1cc(nc2O[C@H](COC(F)F)CCc12)C(N)=O
Show InChI InChI=1S/C15H15F2N3O3S/c1-7-19-5-12(24-7)10-4-11(13(18)21)20-14-9(10)3-2-8(23-14)6-22-15(16)17/h4-5,8,15H,2-3,6H2,1H3,(H2,18,21)/t8-/m0/s1
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n/an/a 2.52E+3n/an/an/an/an/an/a



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US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403442
PNG
((6R,9S)- or (6S,9R)- 4-(1-methyl-1H- pyrazol-4-yl)...)
Show SMILES Cn1cc(cn1)-c1cc(nc2[C@@H]3CC[C@H](Cc12)O3)C(N)=O
Show InChI InChI=1S/C15H16N4O2/c1-19-7-8(6-17-19)10-5-12(15(16)20)18-14-11(10)4-9-2-3-13(14)21-9/h5-7,9,13H,2-4H2,1H3,(H2,16,20)/t9-,13+/m1/s1
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n/an/a>3.00E+3n/an/an/an/an/an/a



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US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403446
PNG
(US10335399, Example 1-6A)
Show SMILES NC(=O)c1cc(c2C[C@H]3CC[C@H](O3)c2n1)-c1ncc(F)cc1F
Show InChI InChI=1S/C16H13F2N3O2/c17-7-3-11(18)14(20-6-7)10-5-12(16(19)22)21-15-9(10)4-8-1-2-13(15)23-8/h3,5-6,8,13H,1-2,4H2,(H2,19,22)/t8-,13+/m1/s1
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US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403444
PNG
((6R,9S)- or (6S,9R)- 4-(1- (difluoromethyl)- 1H-py...)
Show SMILES NC(=O)c1cc(-c2cnn(c2)C(F)F)c2CC3CC[C@H](O3)c2n1
Show InChI InChI=1S/C15H14F2N4O2/c16-15(17)21-6-7(5-19-21)9-4-11(14(18)22)20-13-10(9)3-8-1-2-12(13)23-8/h4-6,8,12,15H,1-3H2,(H2,18,22)/t8?,12-/m0/s1
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n/an/a>3.00E+3n/an/an/an/an/an/a



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US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM403448
PNG
(US10335399, Example 1-7A)
Show SMILES NC(=O)c1cc(c2C[C@H]3CC[C@H](O3)c2n1)-c1ncc(Cl)cc1F
Show InChI InChI=1S/C16H13ClFN3O2/c17-7-3-11(18)14(20-6-7)10-5-12(16(19)22)21-15-9(10)4-8-1-2-13(15)23-8/h3,5-6,8,13H,1-2,4H2,(H2,19,22)/t8-,13+/m1/s1
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n/an/a>3.00E+3n/an/an/an/an/an/a



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US Patent


Assay Description
The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...


US Patent US10335399 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%