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Patent code US10336710

Compile Data Set for Download or QSAR
Found 12 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM403743
PNG
(US10336710, Example I3)
Show SMILES CC(C)(Sc1nc2cc(Br)ccc2n1-c1ccc(C#N)c2ccccc12)C(O)=O
Show InChI InChI=1S/C22H16BrN3O2S/c1-22(2,20(27)28)29-21-25-17-11-14(23)8-10-19(17)26(21)18-9-7-13(12-24)15-5-3-4-6-16(15)18/h3-11H,1-2H3,(H,27,28)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8.00E+3n/an/an/an/an/an/a



TBA

US Patent


Assay Description
A plasmid (EX-T4563-M03, GeneCopoeia) containing the full-length human URAT1 gene (SLC22A12) was transfected into Flp-InT-REx-293 cells to construct ...


US Patent US10336710 (2019)


BindingDB Entry DOI: 10.7270/Q2154FFC
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM403742
PNG
(US10336710, Example I2)
Show SMILES CC(C)(Sc1nc2ccccc2n1-c1ccc(C#N)c2ccccc12)C(O)=O
Show InChI InChI=1S/C22H17N3O2S/c1-22(2,20(26)27)28-21-24-17-9-5-6-10-19(17)25(21)18-12-11-14(13-23)15-7-3-4-8-16(15)18/h3-12H,1-2H3,(H,26,27)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8.00E+3n/an/an/an/an/an/a



TBA

US Patent


Assay Description
A plasmid (EX-T4563-M03, GeneCopoeia) containing the full-length human URAT1 gene (SLC22A12) was transfected into Flp-InT-REx-293 cells to construct ...


US Patent US10336710 (2019)


BindingDB Entry DOI: 10.7270/Q2154FFC
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM403744
PNG
(US10336710, Example I4)
Show SMILES CC(C)(Sc1nc2ccccc2n1-c1ccc(cc1)C#N)C(O)=O
Show InChI InChI=1S/C18H15N3O2S/c1-18(2,16(22)23)24-17-20-14-5-3-4-6-15(14)21(17)13-9-7-12(11-19)8-10-13/h3-10H,1-2H3,(H,22,23)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8.00E+3n/an/an/an/an/an/a



TBA

US Patent


Assay Description
A plasmid (EX-T4563-M03, GeneCopoeia) containing the full-length human URAT1 gene (SLC22A12) was transfected into Flp-InT-REx-293 cells to construct ...


US Patent US10336710 (2019)


BindingDB Entry DOI: 10.7270/Q2154FFC
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM403741
PNG
(US10336710, Example I1)
Show SMILES COc1ccc2n(c(SC(C)(C)C(O)=O)nc2c1)-c1ccc(C#N)c2ccccc12
Show InChI InChI=1S/C23H19N3O3S/c1-23(2,21(27)28)30-22-25-18-12-15(29-3)9-11-20(18)26(22)19-10-8-14(13-24)16-6-4-5-7-17(16)19/h4-12H,1-3H3,(H,27,28)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8.00E+3n/an/an/an/an/an/a



TBA

US Patent


Assay Description
A plasmid (EX-T4563-M03, GeneCopoeia) containing the full-length human URAT1 gene (SLC22A12) was transfected into Flp-InT-REx-293 cells to construct ...


US Patent US10336710 (2019)


BindingDB Entry DOI: 10.7270/Q2154FFC
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM403745
PNG
(US10336710, Example I5)
Show SMILES CC(C)(Sc1nc2ccccc2n1-c1ccc(C2CC2)c2ccccc12)C(O)=O
Show InChI InChI=1S/C24H22N2O2S/c1-24(2,22(27)28)29-23-25-19-9-5-6-10-21(19)26(23)20-14-13-16(15-11-12-15)17-7-3-4-8-18(17)20/h3-10,13-15H,11-12H2,1-2H3,(H,27,28)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.25E+4n/an/an/an/an/an/a



TBA

US Patent


Assay Description
A plasmid (EX-T4563-M03, GeneCopoeia) containing the full-length human URAT1 gene (SLC22A12) was transfected into Flp-InT-REx-293 cells to construct ...


US Patent US10336710 (2019)


BindingDB Entry DOI: 10.7270/Q2154FFC
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM403746
PNG
(US10336710, Example I6)
Show SMILES OC(=O)C(Sc1nc2ccccc2n1-c1ccc(C2CC2)c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H21ClN2O2S/c29-19-13-11-18(12-14-19)26(27(32)33)34-28-30-23-7-3-4-8-25(23)31(28)24-16-15-20(17-9-10-17)21-5-1-2-6-22(21)24/h1-8,11-17,26H,9-10H2,(H,32,33)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.25E+4n/an/an/an/an/an/a



TBA

US Patent


Assay Description
A plasmid (EX-T4563-M03, GeneCopoeia) containing the full-length human URAT1 gene (SLC22A12) was transfected into Flp-InT-REx-293 cells to construct ...


US Patent US10336710 (2019)


BindingDB Entry DOI: 10.7270/Q2154FFC
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM403751
PNG
(US10336710, Example I13)
Show SMILES CC(C)(Sc1nc2ccccc2n1-c1ccccc1F)C(O)=O
Show InChI InChI=1S/C17H15FN2O2S/c1-17(2,15(21)22)23-16-19-12-8-4-6-10-14(12)20(16)13-9-5-3-7-11(13)18/h3-10H,1-2H3,(H,21,22)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.25E+4n/an/an/an/an/an/a



TBA

US Patent


Assay Description
A plasmid (EX-T4563-M03, GeneCopoeia) containing the full-length human URAT1 gene (SLC22A12) was transfected into Flp-InT-REx-293 cells to construct ...


US Patent US10336710 (2019)


BindingDB Entry DOI: 10.7270/Q2154FFC
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM403749
PNG
(US10336710, Example I11)
Show SMILES CC(C)(Sc1nc2ccccc2n1-c1ccc(Br)cc1F)C(O)=O
Show InChI InChI=1S/C17H14BrFN2O2S/c1-17(2,15(22)23)24-16-20-12-5-3-4-6-14(12)21(16)13-8-7-10(18)9-11(13)19/h3-9H,1-2H3,(H,22,23)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.25E+4n/an/an/an/an/an/a



TBA

US Patent


Assay Description
A plasmid (EX-T4563-M03, GeneCopoeia) containing the full-length human URAT1 gene (SLC22A12) was transfected into Flp-InT-REx-293 cells to construct ...


US Patent US10336710 (2019)


BindingDB Entry DOI: 10.7270/Q2154FFC
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM403750
PNG
(US10336710, Example I12)
Show SMILES CC(C)(Sc1nc2ccccc2n1-c1ccc(Cl)cc1F)C(O)=O
Show InChI InChI=1S/C17H14ClFN2O2S/c1-17(2,15(22)23)24-16-20-12-5-3-4-6-14(12)21(16)13-8-7-10(18)9-11(13)19/h3-9H,1-2H3,(H,22,23)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.25E+4n/an/an/an/an/an/a



TBA

US Patent


Assay Description
A plasmid (EX-T4563-M03, GeneCopoeia) containing the full-length human URAT1 gene (SLC22A12) was transfected into Flp-InT-REx-293 cells to construct ...


US Patent US10336710 (2019)


BindingDB Entry DOI: 10.7270/Q2154FFC
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM403748
PNG
(US10336710, Example I8)
Show SMILES CC(C)(Sc1nc2ccccc2n1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C17H16N2O2S/c1-17(2,15(20)21)22-16-18-13-10-6-7-11-14(13)19(16)12-8-4-3-5-9-12/h3-11H,1-2H3,(H,20,21)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.50E+4n/an/an/an/an/an/a



TBA

US Patent


Assay Description
A plasmid (EX-T4563-M03, GeneCopoeia) containing the full-length human URAT1 gene (SLC22A12) was transfected into Flp-InT-REx-293 cells to construct ...


US Patent US10336710 (2019)


BindingDB Entry DOI: 10.7270/Q2154FFC
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM403747
PNG
(US10336710, Example I7)
Show SMILES CC(C)(Sc1nc2ccccc2n1-c1ccc(cc1F)[N+]([O-])=O)C(O)=O
Show InChI InChI=1S/C17H14FN3O4S/c1-17(2,15(22)23)26-16-19-12-5-3-4-6-14(12)20(16)13-8-7-10(21(24)25)9-11(13)18/h3-9H,1-2H3,(H,22,23)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.50E+4n/an/an/an/an/an/a



TBA

US Patent


Assay Description
A plasmid (EX-T4563-M03, GeneCopoeia) containing the full-length human URAT1 gene (SLC22A12) was transfected into Flp-InT-REx-293 cells to construct ...


US Patent US10336710 (2019)


BindingDB Entry DOI: 10.7270/Q2154FFC
More data for this
Ligand-Target Pair
Solute carrier family 22 member 12


(Homo sapiens (Human))
BDBM37953
PNG
(US10093631, Compound Lesinurad | US10336710, Lesin...)
Show SMILES OC(=O)CSc1nnc(Br)n1-c1ccc(C2CC2)c2ccccc12
Show InChI InChI=1S/C17H14BrN3O2S/c18-16-19-20-17(24-9-15(22)23)21(16)14-8-7-11(10-5-6-10)12-3-1-2-4-13(12)14/h1-4,7-8,10H,5-6,9H2,(H,22,23)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6.50E+4n/an/an/an/an/an/a



TBA

US Patent


Assay Description
A plasmid (EX-T4563-M03, GeneCopoeia) containing the full-length human URAT1 gene (SLC22A12) was transfected into Flp-InT-REx-293 cells to construct ...


US Patent US10336710 (2019)


BindingDB Entry DOI: 10.7270/Q2154FFC
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%