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Patent code US10336724

Compile Data Set for Download or QSAR
Found 38 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM406232
PNG
(6-(naphthalen-1-ylmethyl)-3-oxo-2,3-dihydropyridaz...)
Show SMILES O=C(Oc1cc(Cc2cccc3ccccc23)n[nH]c1=O)c1cc(CCc2ccccc2)n[nH]1
Show InChI InChI=1S/C27H22N4O3/c32-26-25(17-22(29-31-26)15-20-11-6-10-19-9-4-5-12-23(19)20)34-27(33)24-16-21(28-30-24)14-13-18-7-2-1-3-8-18/h1-12,16-17H,13-15H2,(H,28,30)(H,31,32)
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n/an/a 55n/an/an/an/an/an/a



SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The pkDAAO (porcine kidney DAAO) activity was measured by using D-Proine as a substrate to produce hydrogen peroxide (H2O2). The produced H2O2 would ...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM406235
PNG
(6-(naphthalen-1-ylmethyl)-3-oxo-2,3-dihydropyridaz...)
Show SMILES O=C(Oc1cc(Cc2cccc3ccccc23)n[nH]c1=O)c1cc(Cc2ccccc2)n[nH]1
Show InChI InChI=1S/C26H20N4O3/c31-25-24(33-26(32)23-15-20(27-29-23)13-17-7-2-1-3-8-17)16-21(28-30-25)14-19-11-6-10-18-9-4-5-12-22(18)19/h1-12,15-16H,13-14H2,(H,27,29)(H,30,31)
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n/an/a 55n/an/an/an/an/an/a



SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The pkDAAO (porcine kidney DAAO) activity was measured by using D-Proine as a substrate to produce hydrogen peroxide (H2O2). The produced H2O2 would ...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM406234
PNG
(6-(naphthalen-1-ylmethyl)-3-oxo-2,3-dihydropyridaz...)
Show SMILES Fc1ccc(CCc2cc([nH]n2)C(=O)Oc2cc(Cc3cccc4ccccc34)n[nH]c2=O)cc1
Show InChI InChI=1S/C27H21FN4O3/c28-20-11-8-17(9-12-20)10-13-21-15-24(31-29-21)27(34)35-25-16-22(30-32-26(25)33)14-19-6-3-5-18-4-1-2-7-23(18)19/h1-9,11-12,15-16H,10,13-14H2,(H,29,31)(H,32,33)
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SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The pkDAAO (porcine kidney DAAO) activity was measured by using D-Proine as a substrate to produce hydrogen peroxide (H2O2). The produced H2O2 would ...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM406239
PNG
(US10336724, Compound Table 1.19)
Show SMILES O=C(Oc1cc(Cc2ccc3ccccc3c2)n[nH]c1=O)c1cc(CCc2ccccc2)n[nH]1
Show InChI InChI=1S/C27H22N4O3/c32-26-25(17-23(29-31-26)15-19-10-12-20-8-4-5-9-21(20)14-19)34-27(33)24-16-22(28-30-24)13-11-18-6-2-1-3-7-18/h1-10,12,14,16-17H,11,13,15H2,(H,28,30)(H,31,32)
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n/an/a 55n/an/an/an/an/an/a



SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The pkDAAO (porcine kidney DAAO) activity was measured by using D-Proine as a substrate to produce hydrogen peroxide (H2O2). The produced H2O2 would ...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM406236
PNG
(US10336724, Compound Table 1.16)
Show SMILES Clc1ccccc1CCc1cc([nH]n1)C(=O)Oc1cc(Cc2cccc3ccccc23)n[nH]c1=O
Show InChI InChI=1S/C27H21ClN4O3/c28-23-11-4-2-7-18(23)12-13-20-15-24(31-29-20)27(34)35-25-16-21(30-32-26(25)33)14-19-9-5-8-17-6-1-3-10-22(17)19/h1-11,15-16H,12-14H2,(H,29,31)(H,32,33)
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SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The pkDAAO (porcine kidney DAAO) activity was measured by using D-Proine as a substrate to produce hydrogen peroxide (H2O2). The produced H2O2 would ...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM406233
PNG
(6-(naphthalen-1-ylmethyl)-3-oxo-2,3-dihydropyridaz...)
Show SMILES Clc1cccc(CCc2cc([nH]n2)C(=O)Oc2cc(Cc3cccc4ccccc34)n[nH]c2=O)c1
Show InChI InChI=1S/C27H21ClN4O3/c28-20-9-3-5-17(13-20)11-12-21-15-24(31-29-21)27(34)35-25-16-22(30-32-26(25)33)14-19-8-4-7-18-6-1-2-10-23(18)19/h1-10,13,15-16H,11-12,14H2,(H,29,31)(H,32,33)
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SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The pkDAAO (porcine kidney DAAO) activity was measured by using D-Proine as a substrate to produce hydrogen peroxide (H2O2). The produced H2O2 would ...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM406238
PNG
(US10336724, Compound Table 1.18)
Show SMILES O=C(Oc1cc(CCc2cccc3ccccc23)n[nH]c1=O)c1cc(CCc2ccccc2)n[nH]1
Show InChI InChI=1S/C28H24N4O3/c33-27-26(35-28(34)25-17-22(29-31-25)15-13-19-7-2-1-3-8-19)18-23(30-32-27)16-14-21-11-6-10-20-9-4-5-12-24(20)21/h1-12,17-18H,13-16H2,(H,29,31)(H,32,33)
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n/an/a 55n/an/an/an/an/an/a



SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The pkDAAO (porcine kidney DAAO) activity was measured by using D-Proine as a substrate to produce hydrogen peroxide (H2O2). The produced H2O2 would ...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM406237
PNG
(US10336724, Compound Table 1.17)
Show SMILES Clc1ccc(CCc2cc([nH]n2)C(=O)Oc2cc(CCc3cccc4ccccc34)n[nH]c2=O)cc1
Show InChI InChI=1S/C28H23ClN4O3/c29-21-12-8-18(9-13-21)10-14-22-16-25(32-30-22)28(35)36-26-17-23(31-33-27(26)34)15-11-20-6-3-5-19-4-1-2-7-24(19)20/h1-9,12-13,16-17H,10-11,14-15H2,(H,30,32)(H,33,34)
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SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The pkDAAO (porcine kidney DAAO) activity was measured by using D-Proine as a substrate to produce hydrogen peroxide (H2O2). The produced H2O2 would ...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM406233
PNG
(6-(naphthalen-1-ylmethyl)-3-oxo-2,3-dihydropyridaz...)
Show SMILES Clc1cccc(CCc2cc([nH]n2)C(=O)Oc2cc(Cc3cccc4ccccc34)n[nH]c2=O)c1
Show InChI InChI=1S/C27H21ClN4O3/c28-20-9-3-5-17(13-20)11-12-21-15-24(31-29-21)27(34)35-25-16-22(30-32-26(25)33)14-19-8-4-7-18-6-1-2-10-23(18)19/h1-10,13,15-16H,11-12,14H2,(H,29,31)(H,32,33)
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n/an/a 300n/an/an/an/an/an/a



SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The hDAAO (human DAAO) activity was measured by using D-serine as a substrate to produce H2O2. The produced H2O2 would be oxidized by peroxidase, and...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM406238
PNG
(US10336724, Compound Table 1.18)
Show SMILES O=C(Oc1cc(CCc2cccc3ccccc23)n[nH]c1=O)c1cc(CCc2ccccc2)n[nH]1
Show InChI InChI=1S/C28H24N4O3/c33-27-26(35-28(34)25-17-22(29-31-25)15-13-19-7-2-1-3-8-19)18-23(30-32-27)16-14-21-11-6-10-20-9-4-5-12-24(20)21/h1-12,17-18H,13-16H2,(H,29,31)(H,32,33)
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SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The hDAAO (human DAAO) activity was measured by using D-serine as a substrate to produce H2O2. The produced H2O2 would be oxidized by peroxidase, and...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM406237
PNG
(US10336724, Compound Table 1.17)
Show SMILES Clc1ccc(CCc2cc([nH]n2)C(=O)Oc2cc(CCc3cccc4ccccc34)n[nH]c2=O)cc1
Show InChI InChI=1S/C28H23ClN4O3/c29-21-12-8-18(9-13-21)10-14-22-16-25(32-30-22)28(35)36-26-17-23(31-33-27(26)34)15-11-20-6-3-5-19-4-1-2-7-24(19)20/h1-9,12-13,16-17H,10-11,14-15H2,(H,30,32)(H,33,34)
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SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The hDAAO (human DAAO) activity was measured by using D-serine as a substrate to produce H2O2. The produced H2O2 would be oxidized by peroxidase, and...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM406234
PNG
(6-(naphthalen-1-ylmethyl)-3-oxo-2,3-dihydropyridaz...)
Show SMILES Fc1ccc(CCc2cc([nH]n2)C(=O)Oc2cc(Cc3cccc4ccccc34)n[nH]c2=O)cc1
Show InChI InChI=1S/C27H21FN4O3/c28-20-11-8-17(9-12-20)10-13-21-15-24(31-29-21)27(34)35-25-16-22(30-32-26(25)33)14-19-6-3-5-18-4-1-2-7-23(18)19/h1-9,11-12,15-16H,10,13-14H2,(H,29,31)(H,32,33)
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SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The hDAAO (human DAAO) activity was measured by using D-serine as a substrate to produce H2O2. The produced H2O2 would be oxidized by peroxidase, and...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM406222
PNG
(5-chloro-2-oxo-1,2-dihydroquinolin-3-yl 4-(4-chlor...)
Show SMILES Clc1ccc(CCc2c[nH]c(c2)C(=O)Oc2cc3c(Cl)cccc3[nH]c2=O)cc1
Show InChI InChI=1S/C22H16Cl2N2O3/c23-15-8-6-13(7-9-15)4-5-14-10-19(25-12-14)22(28)29-20-11-16-17(24)2-1-3-18(16)26-21(20)27/h1-3,6-12,25H,4-5H2,(H,26,27)
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SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The hDAAO (human DAAO) activity was measured by using D-serine as a substrate to produce H2O2. The produced H2O2 would be oxidized by peroxidase, and...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM406239
PNG
(US10336724, Compound Table 1.19)
Show SMILES O=C(Oc1cc(Cc2ccc3ccccc3c2)n[nH]c1=O)c1cc(CCc2ccccc2)n[nH]1
Show InChI InChI=1S/C27H22N4O3/c32-26-25(17-23(29-31-26)15-19-10-12-20-8-4-5-9-21(20)14-19)34-27(33)24-16-22(28-30-24)13-11-18-6-2-1-3-7-18/h1-10,12,14,16-17H,11,13,15H2,(H,28,30)(H,31,32)
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SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The hDAAO (human DAAO) activity was measured by using D-serine as a substrate to produce H2O2. The produced H2O2 would be oxidized by peroxidase, and...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM406228
PNG
(5-chloro-2-oxo-1,2-dihydroquinolin-3-yl 3-(4-chlor...)
Show SMILES Clc1ccc(CCc2cc([nH]n2)C(=O)Oc2cc3c(Cl)cccc3[nH]c2=O)cc1
Show InChI InChI=1S/C21H15Cl2N3O3/c22-13-7-4-12(5-8-13)6-9-14-10-18(26-25-14)21(28)29-19-11-15-16(23)2-1-3-17(15)24-20(19)27/h1-5,7-8,10-11H,6,9H2,(H,24,27)(H,25,26)
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SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The pkDAAO (porcine kidney DAAO) activity was measured by using D-Proine as a substrate to produce hydrogen peroxide (H2O2). The produced H2O2 would ...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM406224
PNG
(5-chloro-2-oxo-1,2-dihydroquinolin-3-yl 3-phenethy...)
Show SMILES Clc1cccc2[nH]c(=O)c(OC(=O)c3cc(CCc4ccccc4)n[nH]3)cc12
Show InChI InChI=1S/C21H16ClN3O3/c22-16-7-4-8-17-15(16)12-19(20(26)23-17)28-21(27)18-11-14(24-25-18)10-9-13-5-2-1-3-6-13/h1-8,11-12H,9-10H2,(H,23,26)(H,24,25)
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SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The hDAAO (human DAAO) activity was measured by using D-serine as a substrate to produce H2O2. The produced H2O2 would be oxidized by peroxidase, and...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM406236
PNG
(US10336724, Compound Table 1.16)
Show SMILES Clc1ccccc1CCc1cc([nH]n1)C(=O)Oc1cc(Cc2cccc3ccccc23)n[nH]c1=O
Show InChI InChI=1S/C27H21ClN4O3/c28-23-11-4-2-7-18(23)12-13-20-15-24(31-29-20)27(34)35-25-16-21(30-32-26(25)33)14-19-9-5-8-17-6-1-3-10-22(17)19/h1-11,15-16H,12-14H2,(H,29,31)(H,32,33)
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SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The hDAAO (human DAAO) activity was measured by using D-serine as a substrate to produce H2O2. The produced H2O2 would be oxidized by peroxidase, and...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM406224
PNG
(5-chloro-2-oxo-1,2-dihydroquinolin-3-yl 3-phenethy...)
Show SMILES Clc1cccc2[nH]c(=O)c(OC(=O)c3cc(CCc4ccccc4)n[nH]3)cc12
Show InChI InChI=1S/C21H16ClN3O3/c22-16-7-4-8-17-15(16)12-19(20(26)23-17)28-21(27)18-11-14(24-25-18)10-9-13-5-2-1-3-6-13/h1-8,11-12H,9-10H2,(H,23,26)(H,24,25)
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SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The pkDAAO (porcine kidney DAAO) activity was measured by using D-Proine as a substrate to produce hydrogen peroxide (H2O2). The produced H2O2 would ...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM406223
PNG
(5-chloro-2-oxo-1,2-dihydroquinolin-3-yl 4-phenethy...)
Show SMILES Clc1cccc2[nH]c(=O)c(OC(=O)c3cc(CCc4ccccc4)c[nH]3)cc12
Show InChI InChI=1S/C22H17ClN2O3/c23-17-7-4-8-18-16(17)12-20(21(26)25-18)28-22(27)19-11-15(13-24-19)10-9-14-5-2-1-3-6-14/h1-8,11-13,24H,9-10H2,(H,25,26)
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n/an/a 550n/an/an/an/an/an/a



SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The hDAAO (human DAAO) activity was measured by using D-serine as a substrate to produce H2O2. The produced H2O2 would be oxidized by peroxidase, and...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM406229
PNG
(5-(((3,4-dichlorophenyl) thio) methyl)-2-oxo-1,2-d...)
Show SMILES Clc1ccc(SCc2c[nH]c(=O)c(OC(=O)c3cc(CCc4ccccc4)n[nH]3)c2)cc1Cl
Show InChI InChI=1S/C24H19Cl2N3O3S/c25-19-9-8-18(12-20(19)26)33-14-16-10-22(23(30)27-13-16)32-24(31)21-11-17(28-29-21)7-6-15-4-2-1-3-5-15/h1-5,8-13H,6-7,14H2,(H,27,30)(H,28,29)
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SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The pkDAAO (porcine kidney DAAO) activity was measured by using D-Proine as a substrate to produce hydrogen peroxide (H2O2). The produced H2O2 would ...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM406232
PNG
(6-(naphthalen-1-ylmethyl)-3-oxo-2,3-dihydropyridaz...)
Show SMILES O=C(Oc1cc(Cc2cccc3ccccc23)n[nH]c1=O)c1cc(CCc2ccccc2)n[nH]1
Show InChI InChI=1S/C27H22N4O3/c32-26-25(17-22(29-31-26)15-20-11-6-10-19-9-4-5-12-23(19)20)34-27(33)24-16-21(28-30-24)14-13-18-7-2-1-3-8-18/h1-12,16-17H,13-15H2,(H,28,30)(H,31,32)
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SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The hDAAO (human DAAO) activity was measured by using D-serine as a substrate to produce H2O2. The produced H2O2 would be oxidized by peroxidase, and...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM406235
PNG
(6-(naphthalen-1-ylmethyl)-3-oxo-2,3-dihydropyridaz...)
Show SMILES O=C(Oc1cc(Cc2cccc3ccccc23)n[nH]c1=O)c1cc(Cc2ccccc2)n[nH]1
Show InChI InChI=1S/C26H20N4O3/c31-25-24(33-26(32)23-15-20(27-29-23)13-17-7-2-1-3-8-17)16-21(28-30-25)14-19-11-6-10-18-9-4-5-12-22(18)19/h1-12,15-16H,13-14H2,(H,27,29)(H,30,31)
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SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The hDAAO (human DAAO) activity was measured by using D-serine as a substrate to produce H2O2. The produced H2O2 would be oxidized by peroxidase, and...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM406228
PNG
(5-chloro-2-oxo-1,2-dihydroquinolin-3-yl 3-(4-chlor...)
Show SMILES Clc1ccc(CCc2cc([nH]n2)C(=O)Oc2cc3c(Cl)cccc3[nH]c2=O)cc1
Show InChI InChI=1S/C21H15Cl2N3O3/c22-13-7-4-12(5-8-13)6-9-14-10-18(26-25-14)21(28)29-19-11-15-16(23)2-1-3-17(15)24-20(19)27/h1-5,7-8,10-11H,6,9H2,(H,24,27)(H,25,26)
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SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The hDAAO (human DAAO) activity was measured by using D-serine as a substrate to produce H2O2. The produced H2O2 would be oxidized by peroxidase, and...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM406231
PNG
(6-(3,5-difluorophenethyl)-3-oxo-2,3-dihydropyridaz...)
Show SMILES Fc1cc(F)cc(CCc2cc(OC(=O)c3cc(CCc4ccc(Cl)cc4)c[nH]3)c(=O)[nH]n2)c1
Show InChI InChI=1S/C25H20ClF2N3O3/c26-18-6-3-15(4-7-18)1-2-17-11-22(29-14-17)25(33)34-23-13-21(30-31-24(23)32)8-5-16-9-19(27)12-20(28)10-16/h3-4,6-7,9-14,29H,1-2,5,8H2,(H,31,32)
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SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The hDAAO (human DAAO) activity was measured by using D-serine as a substrate to produce H2O2. The produced H2O2 would be oxidized by peroxidase, and...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM406229
PNG
(5-(((3,4-dichlorophenyl) thio) methyl)-2-oxo-1,2-d...)
Show SMILES Clc1ccc(SCc2c[nH]c(=O)c(OC(=O)c3cc(CCc4ccccc4)n[nH]3)c2)cc1Cl
Show InChI InChI=1S/C24H19Cl2N3O3S/c25-19-9-8-18(12-20(19)26)33-14-16-10-22(23(30)27-13-16)32-24(31)21-11-17(28-29-21)7-6-15-4-2-1-3-5-15/h1-5,8-13H,6-7,14H2,(H,27,30)(H,28,29)
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SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The hDAAO (human DAAO) activity was measured by using D-serine as a substrate to produce H2O2. The produced H2O2 would be oxidized by peroxidase, and...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM406223
PNG
(5-chloro-2-oxo-1,2-dihydroquinolin-3-yl 4-phenethy...)
Show SMILES Clc1cccc2[nH]c(=O)c(OC(=O)c3cc(CCc4ccccc4)c[nH]3)cc12
Show InChI InChI=1S/C22H17ClN2O3/c23-17-7-4-8-18-16(17)12-20(21(26)25-18)28-22(27)19-11-15(13-24-19)10-9-14-5-2-1-3-6-14/h1-8,11-13,24H,9-10H2,(H,25,26)
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SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The pkDAAO (porcine kidney DAAO) activity was measured by using D-Proine as a substrate to produce hydrogen peroxide (H2O2). The produced H2O2 would ...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM406220
PNG
(6-(hydroxymethyl)-4-oxo-4H-pyran-3-yl 4H-furo[3,2-...)
Show SMILES OCc1cc(=O)c(OC(=O)c2cc3occc3[nH]2)co1
Show InChI InChI=1S/C13H9NO6/c15-5-7-3-10(16)12(6-19-7)20-13(17)9-4-11-8(14-9)1-2-18-11/h1-4,6,14-15H,5H2
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SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The hDAAO (human DAAO) activity was measured by using D-serine as a substrate to produce H2O2. The produced H2O2 would be oxidized by peroxidase, and...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM406230
PNG
(5-(((3,4-dichlorophenyl) thio) methyl)-2-oxo-1,2-d...)
Show SMILES Clc1ccc(SCc2c[nH]c(=O)c(OC(=O)c3cc(CCc4ccccc4)c[nH]3)c2)cc1Cl
Show InChI InChI=1S/C25H20Cl2N2O3S/c26-20-9-8-19(12-21(20)27)33-15-18-11-23(24(30)29-14-18)32-25(31)22-10-17(13-28-22)7-6-16-4-2-1-3-5-16/h1-5,8-14,28H,6-7,15H2,(H,29,30)
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SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The hDAAO (human DAAO) activity was measured by using D-serine as a substrate to produce H2O2. The produced H2O2 would be oxidized by peroxidase, and...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM406230
PNG
(5-(((3,4-dichlorophenyl) thio) methyl)-2-oxo-1,2-d...)
Show SMILES Clc1ccc(SCc2c[nH]c(=O)c(OC(=O)c3cc(CCc4ccccc4)c[nH]3)c2)cc1Cl
Show InChI InChI=1S/C25H20Cl2N2O3S/c26-20-9-8-19(12-21(20)27)33-15-18-11-23(24(30)29-14-18)32-25(31)22-10-17(13-28-22)7-6-16-4-2-1-3-5-16/h1-5,8-14,28H,6-7,15H2,(H,29,30)
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SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The pkDAAO (porcine kidney DAAO) activity was measured by using D-Proine as a substrate to produce hydrogen peroxide (H2O2). The produced H2O2 would ...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM406222
PNG
(5-chloro-2-oxo-1,2-dihydroquinolin-3-yl 4-(4-chlor...)
Show SMILES Clc1ccc(CCc2c[nH]c(c2)C(=O)Oc2cc3c(Cl)cccc3[nH]c2=O)cc1
Show InChI InChI=1S/C22H16Cl2N2O3/c23-15-8-6-13(7-9-15)4-5-14-10-19(25-12-14)22(28)29-20-11-16-17(24)2-1-3-18(16)26-21(20)27/h1-3,6-12,25H,4-5H2,(H,26,27)
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SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The pkDAAO (porcine kidney DAAO) activity was measured by using D-Proine as a substrate to produce hydrogen peroxide (H2O2). The produced H2O2 would ...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM406221
PNG
(6-(((4-chlorophenyl) thio) methyl)-4-oxo-4H-pyran-...)
Show SMILES Clc1ccc(CCc2c[nH]c(c2)C(=O)Oc2coc(CSc3ccc(Cl)cc3)cc2=O)cc1
Show InChI InChI=1S/C25H19Cl2NO4S/c26-18-5-3-16(4-6-18)1-2-17-11-22(28-13-17)25(30)32-24-14-31-20(12-23(24)29)15-33-21-9-7-19(27)8-10-21/h3-14,28H,1-2,15H2
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SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The hDAAO (human DAAO) activity was measured by using D-serine as a substrate to produce H2O2. The produced H2O2 would be oxidized by peroxidase, and...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM406231
PNG
(6-(3,5-difluorophenethyl)-3-oxo-2,3-dihydropyridaz...)
Show SMILES Fc1cc(F)cc(CCc2cc(OC(=O)c3cc(CCc4ccc(Cl)cc4)c[nH]3)c(=O)[nH]n2)c1
Show InChI InChI=1S/C25H20ClF2N3O3/c26-18-6-3-15(4-7-18)1-2-17-11-22(29-14-17)25(33)34-23-13-21(30-31-24(23)32)8-5-16-9-19(27)12-20(28)10-16/h3-4,6-7,9-14,29H,1-2,5,8H2,(H,31,32)
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SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The pkDAAO (porcine kidney DAAO) activity was measured by using D-Proine as a substrate to produce hydrogen peroxide (H2O2). The produced H2O2 would ...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM406221
PNG
(6-(((4-chlorophenyl) thio) methyl)-4-oxo-4H-pyran-...)
Show SMILES Clc1ccc(CCc2c[nH]c(c2)C(=O)Oc2coc(CSc3ccc(Cl)cc3)cc2=O)cc1
Show InChI InChI=1S/C25H19Cl2NO4S/c26-18-5-3-16(4-6-18)1-2-17-11-22(28-13-17)25(30)32-24-14-31-20(12-23(24)29)15-33-21-9-7-19(27)8-10-21/h3-14,28H,1-2,15H2
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SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The pkDAAO (porcine kidney DAAO) activity was measured by using D-Proine as a substrate to produce hydrogen peroxide (H2O2). The produced H2O2 would ...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM406219
PNG
(US10336724, Compound 5)
Show SMILES OCc1cc(=O)c(OC(=O)c2cc(CCc3ccc(Cl)cc3)c[nH]2)co1
Show InChI InChI=1S/C19H16ClNO5/c20-14-5-3-12(4-6-14)1-2-13-7-16(21-9-13)19(24)26-18-11-25-15(10-22)8-17(18)23/h3-9,11,21-22H,1-2,10H2
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SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The pkDAAO (porcine kidney DAAO) activity was measured by using D-Proine as a substrate to produce hydrogen peroxide (H2O2). The produced H2O2 would ...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM406219
PNG
(US10336724, Compound 5)
Show SMILES OCc1cc(=O)c(OC(=O)c2cc(CCc3ccc(Cl)cc3)c[nH]2)co1
Show InChI InChI=1S/C19H16ClNO5/c20-14-5-3-12(4-6-14)1-2-13-7-16(21-9-13)19(24)26-18-11-25-15(10-22)8-17(18)23/h3-9,11,21-22H,1-2,10H2
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SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The hDAAO (human DAAO) activity was measured by using D-serine as a substrate to produce H2O2. The produced H2O2 would be oxidized by peroxidase, and...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM406220
PNG
(6-(hydroxymethyl)-4-oxo-4H-pyran-3-yl 4H-furo[3,2-...)
Show SMILES OCc1cc(=O)c(OC(=O)c2cc3occc3[nH]2)co1
Show InChI InChI=1S/C13H9NO6/c15-5-7-3-10(16)12(6-19-7)20-13(17)9-4-11-8(14-9)1-2-18-11/h1-4,6,14-15H,5H2
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SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The pkDAAO (porcine kidney DAAO) activity was measured by using D-Proine as a substrate to produce hydrogen peroxide (H2O2). The produced H2O2 would ...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM406218
PNG
(6-(hydroxymethyl)-4-oxo-4H-pyran-3-yl 1H-pyrrole-2...)
Show SMILES OCc1cc(=O)c(OC(=O)c2ccc[nH]2)co1
Show InChI InChI=1S/C11H9NO5/c13-5-7-4-9(14)10(6-16-7)17-11(15)8-2-1-3-12-8/h1-4,6,12-13H,5H2
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n/an/a 3.00E+5n/an/an/an/an/an/a



SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The hDAAO (human DAAO) activity was measured by using D-serine as a substrate to produce H2O2. The produced H2O2 would be oxidized by peroxidase, and...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM406218
PNG
(6-(hydroxymethyl)-4-oxo-4H-pyran-3-yl 1H-pyrrole-2...)
Show SMILES OCc1cc(=O)c(OC(=O)c2ccc[nH]2)co1
Show InChI InChI=1S/C11H9NO5/c13-5-7-4-9(14)10(6-16-7)17-11(15)8-2-1-3-12-8/h1-4,6,12-13H,5H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.00E+7n/an/an/an/an/an/a



SyneuRx International (Taiwan) Corp.

US Patent


Assay Description
The pkDAAO (porcine kidney DAAO) activity was measured by using D-Proine as a substrate to produce hydrogen peroxide (H2O2). The produced H2O2 would ...


US Patent US10336724 (2019)


BindingDB Entry DOI: 10.7270/Q290264F
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%