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Patent code US10336733

Compile Data Set for Download or QSAR
Found 50 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406373
PNG
(2-((3,4-trans)-4-Hydroxy-3-(pyridin-2-ylmethyl)chr...)
Show SMILES CC(C)CS(=O)(=O)NC(=O)c1ccccc1-c1ccc2C(O)C(Cc3ccccn3)COc2c1
Show InChI InChI=1S/C26H28N2O5S/c1-17(2)16-34(31,32)28-26(30)22-9-4-3-8-21(22)18-10-11-23-24(14-18)33-15-19(25(23)29)13-20-7-5-6-12-27-20/h3-12,14,17,19,25,29H,13,15-16H2,1-2H3,(H,28,30)
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n/an/an/an/a 24n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406402
PNG
(2-(Rac-trans)-4-Hydroxy-3-((2-phenyloxazol-4-yl)me...)
Show SMILES CC(C)(C)S(=O)(=O)NC(=O)c1ccccc1-c1ccc2[C@@H](O)[C@H](Cc3coc(n3)-c3ccccc3)COc2c1
Show InChI InChI=1S/C30H30N2O6S/c1-30(2,3)39(35,36)32-28(34)24-12-8-7-11-23(24)20-13-14-25-26(16-20)37-17-21(27(25)33)15-22-18-38-29(31-22)19-9-5-4-6-10-19/h4-14,16,18,21,27,33H,15,17H2,1-3H3,(H,32,34)/t21-,27+/m1/s1
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n/an/an/an/a 75n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406381
PNG
(US10336733, Example 25)
Show SMILES CC1(CC1)S(=O)(=O)NC(=O)c1ccccc1-c1ccc2[C@H](O)[C@@H](Cc3cscn3)COc2c1
Show InChI InChI=1S/C24H24N2O5S2/c1-24(8-9-24)33(29,30)26-23(28)19-5-3-2-4-18(19)15-6-7-20-21(11-15)31-12-16(22(20)27)10-17-13-32-14-25-17/h2-7,11,13-14,16,22,27H,8-10,12H2,1H3,(H,26,28)/t16-,22+/m0/s1
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n/an/an/an/a 16n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406384
PNG
(2-(Rac-trans)-4-Hydroxy-3-((1-methyl-1H-pyrazol-5-...)
Show SMILES Cn1nccc1C[C@H]1COc2cc(ccc2[C@@H]1O)-c1ccccc1C(=O)NS(=O)(=O)C1(C)CC1
Show InChI InChI=1S/C25H27N3O5S/c1-25(10-11-25)34(31,32)27-24(30)20-6-4-3-5-19(20)16-7-8-21-22(14-16)33-15-17(23(21)29)13-18-9-12-26-28(18)2/h3-9,12,14,17,23,29H,10-11,13,15H2,1-2H3,(H,27,30)/t17-,23+/m0/s1
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n/an/an/an/a 360n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406398
PNG
(US10336733, Example 42)
Show SMILES O[C@@H]1[C@@H](Cc2ccc(cc2)-c2ccccc2)COc2cc(ccc12)-c1cc(F)ccc1C(=O)NS(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C30H23F4NO5S/c31-23-11-13-24(29(37)35-41(38,39)30(32,33)34)26(16-23)21-10-12-25-27(15-21)40-17-22(28(25)36)14-18-6-8-20(9-7-18)19-4-2-1-3-5-19/h1-13,15-16,22,28,36H,14,17H2,(H,35,37)/t22-,28+/m0/s1
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n/an/an/an/a 35n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406399
PNG
(US10336733, Example 43)
Show SMILES CC1(CC1)S(=O)(=O)NC(=O)c1ccccc1-c1ccc2[C@H](O)[C@@H](Cc3coc(n3)-c3ccccc3)COc2c1
Show InChI InChI=1S/C30H28N2O6S/c1-30(13-14-30)39(35,36)32-28(34)24-10-6-5-9-23(24)20-11-12-25-26(16-20)37-17-21(27(25)33)15-22-18-38-29(31-22)19-7-3-2-4-8-19/h2-12,16,18,21,27,33H,13-15,17H2,1H3,(H,32,34)/t21-,27+/m0/s1
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n/an/an/an/a 19n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406405
PNG
(US10336733, Example 49)
Show SMILES C[C@H](C1COc2cc(ccc2[C@H]1O)-c1ccccc1C(=O)NS(=O)(=O)C1(C)CC1)c1ccccn1
Show InChI InChI=1S/C27H28N2O5S/c1-17(23-9-5-6-14-28-23)22-16-34-24-15-18(10-11-21(24)25(22)30)19-7-3-4-8-20(19)26(31)29-35(32,33)27(2)12-13-27/h3-11,14-15,17,22,25,30H,12-13,16H2,1-2H3,(H,29,31)/t17-,22?,25-/m1/s1
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n/an/an/an/a 154n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406361
PNG
(N-(Cyclopropylsulfonyl)-2-((3R,4S or 3S,4R)-4-hydr...)
Show SMILES O[C@H]1[C@H](Cc2ccccn2)COc2cc(ccc12)-c1ccccc1C(=O)NS(=O)(=O)C1CC1
Show InChI InChI=1S/C25H24N2O5S/c28-24-17(13-18-5-3-4-12-26-18)15-32-23-14-16(8-11-22(23)24)20-6-1-2-7-21(20)25(29)27-33(30,31)19-9-10-19/h1-8,11-12,14,17,19,24,28H,9-10,13,15H2,(H,27,29)/t17-,24+/m1/s1
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n/an/an/an/a 2.17E+3n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406365
PNG
(4-Fluoro-2-((3S,4R or 3R,4S)-4-hydroxy-3-(pyridin-...)
Show SMILES CC1(CC1)S(=O)(=O)NC(=O)c1ccc(F)cc1-c1ccc2[C@H](O)[C@@H](Cc3ccccn3)COc2c1
Show InChI InChI=1S/C26H25FN2O5S/c1-26(9-10-26)35(32,33)29-25(31)20-8-6-18(27)14-22(20)16-5-7-21-23(13-16)34-15-17(24(21)30)12-19-4-2-3-11-28-19/h2-8,11,13-14,17,24,30H,9-10,12,15H2,1H3,(H,29,31)/t17-,24+/m0/s1
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n/an/an/an/a 4n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406371
PNG
(N-(Cyclopropylsulfonyl)-4-fluoro-2-((3R,4S or 3S,4...)
Show SMILES O[C@H]1[C@H](Cc2ccccn2)COc2cc(ccc12)-c1cc(F)ccc1C(=O)NS(=O)(=O)C1CC1
Show InChI InChI=1S/C25H23FN2O5S/c26-17-5-9-20(25(30)28-34(31,32)19-6-7-19)22(13-17)15-4-8-21-23(12-15)33-14-16(24(21)29)11-18-3-1-2-10-27-18/h1-5,8-10,12-13,16,19,24,29H,6-7,11,14H2,(H,28,30)/t16-,24+/m1/s1
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n/an/an/an/a 480n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406376
PNG
(2-((3,4-trans)-4-Hydroxy-3-(pyridin-2-ylmethyl)chr...)
Show SMILES CC(C)(C)CS(=O)(=O)NC(=O)c1ccccc1-c1ccc2C(O)C(Cc3ccccn3)COc2c1
Show InChI InChI=1S/C27H30N2O5S/c1-27(2,3)17-35(32,33)29-26(31)22-10-5-4-9-21(22)18-11-12-23-24(15-18)34-16-19(25(23)30)14-20-8-6-7-13-28-20/h4-13,15,19,25,30H,14,16-17H2,1-3H3,(H,29,31)
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n/an/an/an/a 44n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406385
PNG
(2-((Rac-trans)-4-Hydroxy-3-((5-methyl-1,3,4-thiadi...)
Show SMILES Cc1nnc(C[C@H]2COc3cc(ccc3[C@@H]2O)-c2ccccc2C(=O)NS(=O)(=O)C2(C)CC2)s1
Show InChI InChI=1S/C24H25N3O5S2/c1-14-25-26-21(33-14)12-16-13-32-20-11-15(7-8-19(20)22(16)28)17-5-3-4-6-18(17)23(29)27-34(30,31)24(2)9-10-24/h3-8,11,16,22,28H,9-10,12-13H2,1-2H3,(H,27,29)/t16-,22+/m0/s1
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n/an/an/an/a 740n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406391
PNG
(N-(tert-Butylsulfonyl)-2-((rac-trans)-4-hydroxy-3-...)
Show SMILES Cn1nccc1C[C@H]1COc2cc(ccc2[C@@H]1O)-c1ccccc1C(=O)NS(=O)(=O)C(C)(C)C
Show InChI InChI=1S/C25H29N3O5S/c1-25(2,3)34(31,32)27-24(30)20-8-6-5-7-19(20)16-9-10-21-22(14-16)33-15-17(23(21)29)13-18-11-12-26-28(18)4/h5-12,14,17,23,29H,13,15H2,1-4H3,(H,27,30)/t17-,23+/m0/s1
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n/an/an/an/a 95n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406396
PNG
(2-((Rac-trans)-3-([1,1′-Biphenyl]-4-ylmethyl...)
Show SMILES O[C@H]1[C@H](Cc2ccc(cc2)-c2ccccc2)COc2cc(ccc12)-c1cc(F)ccc1C(=O)NS(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C30H23F4NO5S/c31-23-11-13-24(29(37)35-41(38,39)30(32,33)34)26(16-23)21-10-12-25-27(15-21)40-17-22(28(25)36)14-18-6-8-20(9-7-18)19-4-2-1-3-5-19/h1-13,15-16,22,28,36H,14,17H2,(H,35,37)/t22-,28+/m1/s1
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n/an/an/an/a 9n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406396
PNG
(2-((Rac-trans)-3-([1,1′-Biphenyl]-4-ylmethyl...)
Show SMILES O[C@H]1[C@H](Cc2ccc(cc2)-c2ccccc2)COc2cc(ccc12)-c1cc(F)ccc1C(=O)NS(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C30H23F4NO5S/c31-23-11-13-24(29(37)35-41(38,39)30(32,33)34)26(16-23)21-10-12-25-27(15-21)40-17-22(28(25)36)14-18-6-8-20(9-7-18)19-4-2-1-3-5-19/h1-13,15-16,22,28,36H,14,17H2,(H,35,37)/t22-,28+/m1/s1
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n/an/an/an/a 11n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406364
PNG
(2-((3S,4R or 3R,4S)-4-Hydroxy-3-(pyridin-2-ylmethy...)
Show SMILES CC1(CC1)S(=O)(=O)NC(=O)c1ccccc1-c1ccc2[C@H](O)[C@@H](Cc3ccccn3)COc2c1
Show InChI InChI=1S/C26H26N2O5S/c1-26(11-12-26)34(31,32)28-25(30)21-8-3-2-7-20(21)17-9-10-22-23(15-17)33-16-18(24(22)29)14-19-6-4-5-13-27-19/h2-10,13,15,18,24,29H,11-12,14,16H2,1H3,(H,28,30)/t18-,24+/m0/s1
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n/an/an/an/a 22n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406369
PNG
(N-(tert-Butylsulfonyl)-4-fluoro-2-((3R,4S or 3S,4R...)
Show SMILES CC(C)S(=O)(=O)NC(=O)c1ccc(F)cc1-c1ccc2[C@@H](O)[C@H](Cc3ccccn3)COc2c1
Show InChI InChI=1S/C25H25FN2O5S/c1-15(2)34(31,32)28-25(30)20-9-7-18(26)13-22(20)16-6-8-21-23(12-16)33-14-17(24(21)29)11-19-5-3-4-10-27-19/h3-10,12-13,15,17,24,29H,11,14H2,1-2H3,(H,28,30)/t17-,24+/m1/s1
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n/an/an/an/a 441n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406372
PNG
(N-(Cyclopropylsulfonyl)-4-fluoro-2-((3S,4R or 3R,4...)
Show SMILES O[C@@H]1[C@@H](Cc2ccccn2)COc2cc(ccc12)-c1cc(F)ccc1C(=O)NS(=O)(=O)C1CC1
Show InChI InChI=1S/C25H23FN2O5S/c26-17-5-9-20(25(30)28-34(31,32)19-6-7-19)22(13-17)15-4-8-21-23(12-15)33-14-16(24(21)29)11-18-3-1-2-10-27-18/h1-5,8-10,12-13,16,19,24,29H,6-7,11,14H2,(H,28,30)/t16-,24+/m0/s1
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n/an/an/an/a 4n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406374
PNG
(N-((Cyclopropylmethyl)sulfonyl)-2-((3,4-trans)-4-h...)
Show SMILES OC1C(Cc2ccccn2)COc2cc(ccc12)-c1ccccc1C(=O)NS(=O)(=O)CC1CC1
Show InChI InChI=1S/C26H26N2O5S/c29-25-19(13-20-5-3-4-12-27-20)15-33-24-14-18(10-11-23(24)25)21-6-1-2-7-22(21)26(30)28-34(31,32)16-17-8-9-17/h1-7,10-12,14,17,19,25,29H,8-9,13,15-16H2,(H,28,30)
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n/an/an/an/a 23n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406379
PNG
(2-((3R,4S or 3S,4R)-3-Benzyl-4-hydroxychroman-7-yl...)
Show SMILES O[C@H]1[C@H](Cc2ccccc2)COc2cc(ccc12)-c1ccccc1C(=O)NS(=O)(=O)C1CC1
Show InChI InChI=1S/C26H25NO5S/c28-25-19(14-17-6-2-1-3-7-17)16-32-24-15-18(10-13-23(24)25)21-8-4-5-9-22(21)26(29)27-33(30,31)20-11-12-20/h1-10,13,15,19-20,25,28H,11-12,14,16H2,(H,27,29)/t19-,25+/m1/s1
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n/an/an/an/a 2.82E+3n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406389
PNG
(N-(tert-Butylsulfonyl)-2-((3R,4S or 3S,4R)-4-hydro...)
Show SMILES CC(C)(C)S(=O)(=O)NC(=O)c1ccccc1-c1ccc2[C@@H](O)[C@H](Cc3cscn3)COc2c1
Show InChI InChI=1S/C24H26N2O5S2/c1-24(2,3)33(29,30)26-23(28)19-7-5-4-6-18(19)15-8-9-20-21(11-15)31-12-16(22(20)27)10-17-13-32-14-25-17/h4-9,11,13-14,16,22,27H,10,12H2,1-3H3,(H,26,28)/t16-,22+/m1/s1
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n/an/an/an/a 808n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406394
PNG
(N-(tert-Butylsulfonyl)-2-((3R,4S or 3S,4R)-3-((1-e...)
Show SMILES CCn1nccc1C[C@@H]1COc2cc(ccc2[C@H]1O)-c1ccccc1C(=O)NS(=O)(=O)C(C)(C)C
Show InChI InChI=1S/C26H31N3O5S/c1-5-29-19(12-13-27-29)14-18-16-34-23-15-17(10-11-22(23)24(18)30)20-8-6-7-9-21(20)25(31)28-35(32,33)26(2,3)4/h6-13,15,18,24,30H,5,14,16H2,1-4H3,(H,28,31)/t18-,24+/m1/s1
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n/an/an/an/a 1.16E+3n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406400
PNG
(US10336733, Example 44)
Show SMILES CC1(CC1)S(=O)(=O)NC(=O)c1ccccc1-c1ccc2[C@@H](O)[C@H](Cc3coc(n3)-c3ccccc3)COc2c1
Show InChI InChI=1S/C30H28N2O6S/c1-30(13-14-30)39(35,36)32-28(34)24-10-6-5-9-23(24)20-11-12-25-26(16-20)37-17-21(27(25)33)15-22-18-38-29(31-22)19-7-3-2-4-8-19/h2-12,16,18,21,27,33H,13-15,17H2,1H3,(H,32,34)/t21-,27+/m1/s1
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n/an/an/an/a 60n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406357
PNG
(4-Fluoro-2-((3R,4S or 3S,4R)-4-hydroxy-3-(pyridin-...)
Show SMILES O[C@H]1[C@H](Cc2ccccn2)COc2cc(ccc12)-c1cc(F)ccc1C(=O)NS(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C23H18F4N2O5S/c24-15-5-7-17(22(31)29-35(32,33)23(25,26)27)19(11-15)13-4-6-18-20(10-13)34-12-14(21(18)30)9-16-3-1-2-8-28-16/h1-8,10-11,14,21,30H,9,12H2,(H,29,31)/t14-,21+/m1/s1
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n/an/an/an/a 650n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406358
PNG
(4-Fluoro-2-((3S,4R or 3R,4S)-4-hydroxy-3-(pyridin-...)
Show SMILES O[C@@H]1[C@@H](Cc2ccccn2)COc2cc(ccc12)-c1cc(F)ccc1C(=O)NS(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C23H18F4N2O5S/c24-15-5-7-17(22(31)29-35(32,33)23(25,26)27)19(11-15)13-4-6-18-20(10-13)34-12-14(21(18)30)9-16-3-1-2-8-28-16/h1-8,10-11,14,21,30H,9,12H2,(H,29,31)/t14-,21+/m0/s1
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n/an/an/an/a 6n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406359
PNG
(4-Fluoro-2-((3R,4S or 3S,4R)-4-hydroxy-3-(pyridin-...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(F)cc1-c1ccc2[C@@H](O)[C@H](Cc3ccccn3)COc2c1
Show InChI InChI=1S/C23H21FN2O5S/c1-32(29,30)26-23(28)18-8-6-16(24)12-20(18)14-5-7-19-21(11-14)31-13-15(22(19)27)10-17-4-2-3-9-25-17/h2-9,11-12,15,22,27H,10,13H2,1H3,(H,26,28)/t15-,22+/m1/s1
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n/an/an/an/a 1.72E+3n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406360
PNG
(4-Fluoro-2-((3S,4R or 3R,4S)-4-hydroxy-3-(pyridin-...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(F)cc1-c1ccc2[C@H](O)[C@@H](Cc3ccccn3)COc2c1
Show InChI InChI=1S/C23H21FN2O5S/c1-32(29,30)26-23(28)18-8-6-16(24)12-20(18)14-5-7-19-21(11-14)31-13-15(22(19)27)10-17-4-2-3-9-25-17/h2-9,11-12,15,22,27H,10,13H2,1H3,(H,26,28)/t15-,22+/m0/s1
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n/an/an/an/a 93n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406380
PNG
(2-((3S,4R or 3R,4S)-3-Benzyl-4-hydroxychroman-7-yl...)
Show SMILES O[C@@H]1[C@@H](Cc2ccccc2)COc2cc(ccc12)-c1ccccc1C(=O)NS(=O)(=O)C1CC1
Show InChI InChI=1S/C26H25NO5S/c28-25-19(14-17-6-2-1-3-7-17)16-32-24-15-18(10-13-23(24)25)21-8-4-5-9-22(21)26(29)27-33(30,31)20-11-12-20/h1-10,13,15,19-20,25,28H,11-12,14,16H2,(H,27,29)/t19-,25+/m0/s1
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n/an/an/an/a 17n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406386
PNG
(2-((Rac-trans)-3-((1-ethyl-1H-pyrazol-5-yl)methyl)...)
Show SMILES CCn1nccc1C[C@@H]1COc2cc(ccc2[C@H]1O)-c1ccccc1C(=O)NS(=O)(=O)C1(C)CC1
Show InChI InChI=1S/C26H29N3O5S/c1-3-29-19(10-13-27-29)14-18-16-34-23-15-17(8-9-22(23)24(18)30)20-6-4-5-7-21(20)25(31)28-35(32,33)26(2)11-12-26/h4-10,13,15,18,24,30H,3,11-12,14,16H2,1-2H3,(H,28,31)/t18-,24+/m1/s1
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n/an/an/an/a 538n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406392
PNG
(N-(tert-Butylsulfonyl)-2-((rac-trans)-3-((1-ethyl-...)
Show SMILES CCn1nccc1C[C@H]1COc2cc(ccc2[C@@H]1O)-c1ccccc1C(=O)NS(=O)(=O)C(C)(C)C
Show InChI InChI=1S/C26H31N3O5S/c1-5-29-19(12-13-27-29)14-18-16-34-23-15-17(10-11-22(23)24(18)30)20-8-6-7-9-21(20)25(31)28-35(32,33)26(2,3)4/h6-13,15,18,24,30H,5,14,16H2,1-4H3,(H,28,31)/t18-,24+/m0/s1
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n/an/an/an/a 81n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406392
PNG
(N-(tert-Butylsulfonyl)-2-((rac-trans)-3-((1-ethyl-...)
Show SMILES CCn1nccc1C[C@H]1COc2cc(ccc2[C@@H]1O)-c1ccccc1C(=O)NS(=O)(=O)C(C)(C)C
Show InChI InChI=1S/C26H31N3O5S/c1-5-29-19(12-13-27-29)14-18-16-34-23-15-17(10-11-22(23)24(18)30)20-8-6-7-9-21(20)25(31)28-35(32,33)26(2,3)4/h6-13,15,18,24,30H,5,14,16H2,1-4H3,(H,28,31)/t18-,24+/m0/s1
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n/an/an/an/a 36n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406401
PNG
(US10336733, Example 45)
Show SMILES CC1(CC1)S(=O)(=O)NC(=O)c1ccccc1-c1ccc2[C@H](O)[C@H](Cc3coc(n3)-c3ccccc3)COc2c1
Show InChI InChI=1S/C30H28N2O6S/c1-30(13-14-30)39(35,36)32-28(34)24-10-6-5-9-23(24)20-11-12-25-26(16-20)37-17-21(27(25)33)15-22-18-38-29(31-22)19-7-3-2-4-8-19/h2-12,16,18,21,27,33H,13-15,17H2,1H3,(H,32,34)/t21-,27-/m1/s1
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n/an/an/an/a 3n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406402
PNG
(2-(Rac-trans)-4-Hydroxy-3-((2-phenyloxazol-4-yl)me...)
Show SMILES CC(C)(C)S(=O)(=O)NC(=O)c1ccccc1-c1ccc2[C@@H](O)[C@H](Cc3coc(n3)-c3ccccc3)COc2c1
Show InChI InChI=1S/C30H30N2O6S/c1-30(2,3)39(35,36)32-28(34)24-12-8-7-11-23(24)20-13-14-25-26(16-20)37-17-21(27(25)33)15-22-18-38-29(31-22)19-9-5-4-6-10-19/h4-14,16,18,21,27,33H,15,17H2,1-3H3,(H,32,34)/t21-,27+/m1/s1
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n/an/an/an/a 15n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406406
PNG
(US10336733, Example 50)
Show SMILES C[C@@H](C1COc2cc(ccc2[C@H]1O)-c1ccccc1C(=O)NS(=O)(=O)C1(C)CC1)c1ccccn1
Show InChI InChI=1S/C27H28N2O5S/c1-17(23-9-5-6-14-28-23)22-16-34-24-15-18(10-11-21(24)25(22)30)19-7-3-4-8-20(19)26(31)29-35(32,33)27(2)12-13-27/h3-11,14-15,17,22,25,30H,12-13,16H2,1-2H3,(H,29,31)/t17-,22?,25+/m0/s1
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n/an/an/an/a 67n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406382
PNG
(US10336733, Example 26)
Show SMILES CC1(CC1)S(=O)(=O)NC(=O)c1ccccc1-c1ccc2[C@@H](O)[C@H](Cc3cscn3)COc2c1
Show InChI InChI=1S/C24H24N2O5S2/c1-24(8-9-24)33(29,30)26-23(28)19-5-3-2-4-18(19)15-6-7-20-21(11-15)31-12-16(22(20)27)10-17-13-32-14-25-17/h2-7,11,13-14,16,22,27H,8-10,12H2,1H3,(H,26,28)/t16-,22+/m1/s1
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n/an/an/an/a 770n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406388
PNG
(N-(tert-Butylsulfonyl)-2-((rac-trans)-4-hydroxy-3-...)
Show SMILES CC(C)(C)S(=O)(=O)NC(=O)c1ccccc1-c1ccc2[C@H](O)[C@@H](Cc3cscn3)COc2c1
Show InChI InChI=1S/C24H26N2O5S2/c1-24(2,3)33(29,30)26-23(28)19-7-5-4-6-18(19)15-8-9-20-21(11-15)31-12-16(22(20)27)10-17-13-32-14-25-17/h4-9,11,13-14,16,22,27H,10,12H2,1-3H3,(H,26,28)/t16-,22+/m0/s1
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n/an/an/an/a 11n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406363
PNG
(2-((3R,4S or 3S,4R)-4-Hydroxy-3-(pyridin-2-ylmethy...)
Show SMILES CC1(CC1)S(=O)(=O)NC(=O)c1ccccc1-c1ccc2[C@@H](O)[C@H](Cc3ccccn3)COc2c1
Show InChI InChI=1S/C26H26N2O5S/c1-26(11-12-26)34(31,32)28-25(30)21-8-3-2-7-20(21)17-9-10-22-23(15-17)33-16-18(24(22)29)14-19-6-4-5-13-27-19/h2-10,13,15,18,24,29H,11-12,14,16H2,1H3,(H,28,30)/t18-,24+/m1/s1
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n/an/an/an/a 1.27E+3n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406366
PNG
(4-Fluoro-2-((3R,4S or 3S,4R)-4-hydroxy-3-(pyridin-...)
Show SMILES CC1(CC1)S(=O)(=O)NC(=O)c1ccc(F)cc1-c1ccc2[C@@H](O)[C@H](Cc3ccccn3)COc2c1
Show InChI InChI=1S/C26H25FN2O5S/c1-26(9-10-26)35(32,33)29-25(31)20-8-6-18(27)14-22(20)16-5-7-21-23(13-16)34-15-17(24(21)30)12-19-4-2-3-11-28-19/h2-8,11,13-14,17,24,30H,9-10,12,15H2,1H3,(H,29,31)/t17-,24+/m1/s1
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n/an/an/an/a 870n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406367
PNG
(N-(tert-Butylsulfonyl)-2-((3R,4S or 3S,4R)-4-hydro...)
Show SMILES CC(C)(C)S(=O)(=O)NC(=O)c1ccccc1-c1ccc2[C@@H](O)[C@H](Cc3ccccn3)COc2c1
Show InChI InChI=1S/C26H28N2O5S/c1-26(2,3)34(31,32)28-25(30)21-10-5-4-9-20(21)17-11-12-22-23(15-17)33-16-18(24(22)29)14-19-8-6-7-13-27-19/h4-13,15,18,24,29H,14,16H2,1-3H3,(H,28,30)/t18-,24+/m1/s1
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n/an/an/an/a 144n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406383
PNG
(US10336733, Example 27)
Show SMILES CC1(CC1)S(=O)(=O)NC(=O)c1ccccc1-c1ccc2[C@H](O)[C@H](Cc3cscn3)COc2c1
Show InChI InChI=1S/C24H24N2O5S2/c1-24(8-9-24)33(29,30)26-23(28)19-5-3-2-4-18(19)15-6-7-20-21(11-15)31-12-16(22(20)27)10-17-13-32-14-25-17/h2-7,11,13-14,16,22,27H,8-10,12H2,1H3,(H,26,28)/t16-,22-/m1/s1
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n/an/an/an/a 26n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406368
PNG
(N-(tert-Butylsulfonyl)-2-((3S,4R or 3R,4S)-4-hydro...)
Show SMILES CC(C)(C)S(=O)(=O)NC(=O)c1ccccc1-c1ccc2[C@H](O)[C@@H](Cc3ccccn3)COc2c1
Show InChI InChI=1S/C26H28N2O5S/c1-26(2,3)34(31,32)28-25(30)21-10-5-4-9-20(21)17-11-12-22-23(15-17)33-16-18(24(22)29)14-19-8-6-7-13-27-19/h4-13,15,18,24,29H,14,16H2,1-3H3,(H,28,30)/t18-,24+/m0/s1
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n/an/an/an/a 17n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406370
PNG
(N-(tert-Butylsulfonyl)-4-fluoro-2-((3S,4R or 3R,4S...)
Show SMILES CC(C)(C)S(=O)(=O)NC(=O)c1ccc(F)cc1-c1ccc2[C@H](O)[C@@H](Cc3ccccn3)COc2c1
Show InChI InChI=1S/C26H27FN2O5S/c1-26(2,3)35(32,33)29-25(31)20-10-8-18(27)14-22(20)16-7-9-21-23(13-16)34-15-17(24(21)30)12-19-6-4-5-11-28-19/h4-11,13-14,17,24,30H,12,15H2,1-3H3,(H,29,31)/t17-,24+/m0/s1
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n/an/an/an/a 2n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406378
PNG
(2-((3S,4R or 3R,4S)-3-Benzyl-4-hydroxychroman-7-yl...)
Show SMILES CC1(CC1)S(=O)(=O)NC(=O)c1ccccc1-c1ccc2[C@H](O)[C@@H](Cc3ccccc3)COc2c1
Show InChI InChI=1S/C27H27NO5S/c1-27(13-14-27)34(31,32)28-26(30)22-10-6-5-9-21(22)19-11-12-23-24(16-19)33-17-20(25(23)29)15-18-7-3-2-4-8-18/h2-12,16,20,25,29H,13-15,17H2,1H3,(H,28,30)/t20-,25+/m0/s1
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n/an/an/an/a 15n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406387
PNG
(N-(tert-Butylsulfonyl)-2-((rac-trans)-4-hydroxy-3-...)
Show SMILES Cc1nnc(C[C@H]2COc3cc(ccc3[C@@H]2O)-c2ccccc2C(=O)NS(=O)(=O)C(C)(C)C)s1
Show InChI InChI=1S/C24H27N3O5S2/c1-14-25-26-21(33-14)12-16-13-32-20-11-15(9-10-19(20)22(16)28)17-7-5-6-8-18(17)23(29)27-34(30,31)24(2,3)4/h5-11,16,22,28H,12-13H2,1-4H3,(H,27,29)/t16-,22+/m0/s1
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n/an/an/an/a 556n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406388
PNG
(N-(tert-Butylsulfonyl)-2-((rac-trans)-4-hydroxy-3-...)
Show SMILES CC(C)(C)S(=O)(=O)NC(=O)c1ccccc1-c1ccc2[C@H](O)[C@@H](Cc3cscn3)COc2c1
Show InChI InChI=1S/C24H26N2O5S2/c1-24(2,3)33(29,30)26-23(28)19-7-5-4-6-18(19)15-8-9-20-21(11-15)31-12-16(22(20)27)10-17-13-32-14-25-17/h4-9,11,13-14,16,22,27H,10,12H2,1-3H3,(H,26,28)/t16-,22+/m0/s1
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n/an/an/an/a 9n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406395
PNG
(2-((Rac-cis)-3-([1,1′-Biphenyl]-4-ylmethyl)-...)
Show SMILES O[C@@H]1[C@H](Cc2ccc(cc2)-c2ccccc2)COc2cc(ccc12)-c1cc(F)ccc1C(=O)NS(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C30H23F4NO5S/c31-23-11-13-24(29(37)35-41(38,39)30(32,33)34)26(16-23)21-10-12-25-27(15-21)40-17-22(28(25)36)14-18-6-8-20(9-7-18)19-4-2-1-3-5-19/h1-13,15-16,22,28,36H,14,17H2,(H,35,37)/t22-,28-/m1/s1
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n/an/an/an/a 37n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406404
PNG
(N-(tert-Butylsulfonyl)-2-((3S,4R or 3R,4S)-4-hydro...)
Show SMILES CC(C)(C)S(=O)(=O)NC(=O)c1ccccc1-c1ccc2[C@H](O)[C@@H](Cc3coc(n3)-c3ccccc3)COc2c1
Show InChI InChI=1S/C30H30N2O6S/c1-30(2,3)39(35,36)32-28(34)24-12-8-7-11-23(24)20-13-14-25-26(16-20)37-17-21(27(25)33)15-22-18-38-29(31-22)19-9-5-4-6-10-19/h4-14,16,18,21,27,33H,15,17H2,1-3H3,(H,32,34)/t21-,27+/m0/s1
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n/an/an/an/a 5n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406362
PNG
(N-(Cyclopropylsulfonyl)-2-((3S,4R or 3R,4S)-4-hydr...)
Show SMILES O[C@@H]1[C@@H](Cc2ccccn2)COc2cc(ccc12)-c1ccccc1C(=O)NS(=O)(=O)C1CC1
Show InChI InChI=1S/C25H24N2O5S/c28-24-17(13-18-5-3-4-12-26-18)15-32-23-14-16(8-11-22(23)24)20-6-1-2-7-21(20)25(29)27-33(30,31)19-9-10-19/h1-8,11-12,14,17,19,24,28H,9-10,13,15H2,(H,27,29)/t17-,24+/m0/s1
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n/an/an/an/a 28n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406375
PNG
(N-(Cyclopentylsulfonyl)-2-((3,4-trans)-4-hydroxy-3...)
Show SMILES OC1C(Cc2ccccn2)COc2cc(ccc12)-c1ccccc1C(=O)NS(=O)(=O)C1CCCC1
Show InChI InChI=1S/C27H28N2O5S/c30-26-19(15-20-7-5-6-14-28-20)17-34-25-16-18(12-13-24(25)26)22-10-3-4-11-23(22)27(31)29-35(32,33)21-8-1-2-9-21/h3-7,10-14,16,19,21,26,30H,1-2,8-9,15,17H2,(H,29,31)
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n/an/an/an/a 48n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))		BDBM406377
PNG
(2-((3R,4S or 3S,4R)-3-Benzyl-4-hydroxychroman-7-yl...)
Show SMILES CC1(CC1)S(=O)(=O)NC(=O)c1ccccc1-c1ccc2[C@@H](O)[C@H](Cc3ccccc3)COc2c1
Show InChI InChI=1S/C27H27NO5S/c1-27(13-14-27)34(31,32)28-26(30)22-10-6-5-9-21(22)19-11-12-23-24(16-19)33-17-20(25(23)29)15-18-7-3-2-4-8-18/h2-12,16,20,25,29H,13-15,17H2,1H3,(H,28,30)/t20-,25+/m1/s1
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n/an/an/an/a 2.04E+3n/an/an/an/a



Merk Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to antagonize the human BLT1 receptor was determined using a kit to measure changes in intracellular cyclic AMP levels (cAMP...

US Patent US10336733 (2019)


BindingDB Entry DOI: 10.7270/Q2RX9FFC
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%