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Patent code US10336739

Compile Data Set for Download or QSAR

Found 253 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Apelin receptor


(Homo sapiens (Human))
BDBM406458
PNG
(6-butyl-5-(2,6- dimethoxyphenyl)- 3-{5-[(3-methyl-...)
Show SMILES CCCCc1nc(O)c(-c2nnc(Cc3cc(C)no3)o2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C24H26N4O6/c1-5-6-8-15-19(20-16(31-3)9-7-10-17(20)32-4)22(29)21(23(30)25-15)24-27-26-18(33-24)12-14-11-13(2)28-34-14/h7,9-11H,5-6,8,12H2,1-4H3,(H2,25,29,30)
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n/an/an/an/a 5.5n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406472
PNG
(6-butyl-5-(2,6- dimethoxyphenyl)- 3-{5-[4- (triflu...)
Show SMILES CCCCc1nc(O)c(-c2nnc(COc3ccc(cc3)C(F)(F)F)o2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C27H26F3N3O6/c1-4-5-7-17-21(22-18(36-2)8-6-9-19(22)37-3)24(34)23(25(35)31-17)26-33-32-20(39-26)14-38-16-12-10-15(11-13-16)27(28,29)30/h6,8-13H,4-5,7,14H2,1-3H3,(H2,31,34,35)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406474
PNG
(6-butyl-3-[5- (cyclohexylmethyl)- 1,3,4-oxadiazol-...)
Show SMILES CCCCc1nc(O)c(-c2nnc(CC3CCCCC3)o2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C26H33N3O5/c1-4-5-12-17-21(22-18(32-2)13-9-14-19(22)33-3)24(30)23(25(31)27-17)26-29-28-20(34-26)15-16-10-7-6-8-11-16/h9,13-14,16H,4-8,10-12,15H2,1-3H3,(H2,27,30,31)
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n/an/an/an/a 5.5n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406494
PNG
(6-butyl-3-{5-[(4- chlorophenyl) methyl]-1,3,4- oxa...)
Show SMILES CCCCc1nc(O)c(-c2nnc(Cc3ccc(Cl)cc3)o2)c(O)c1-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C24H20Cl3N3O3/c1-2-3-7-17-20(19-15(26)5-4-6-16(19)27)22(31)21(23(32)28-17)24-30-29-18(33-24)12-13-8-10-14(25)11-9-13/h4-6,8-11H,2-3,7,12H2,1H3,(H2,28,31,32)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406501
PNG
(6-cyclopropyl-5- (2,6- dimethoxyphenyl) 3-{5-[(2-m...)
Show SMILES COc1cccc(OC)c1-c1c(O)c(-c2nnc(Cc3csc(C)n3)o2)c(O)nc1C1CC1
Show InChI InChI=1S/C23H22N4O5S/c1-11-24-13(10-33-11)9-16-26-27-23(32-16)19-21(28)18(20(12-7-8-12)25-22(19)29)17-14(30-2)5-4-6-15(17)31-3/h4-6,10,12H,7-9H2,1-3H3,(H2,25,28,29)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406520
PNG
(1-({5-[6-butyl-5- (2,6- dimethoxyphenyl)- 2,4- dih...)
Show SMILES CCCCc1nc(O)c(-c2nnc(Cn3ccccc3=O)o2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C25H26N4O6/c1-4-5-9-15-20(21-16(33-2)10-8-11-17(21)34-3)23(31)22(24(32)26-15)25-28-27-18(35-25)14-29-13-7-6-12-19(29)30/h6-8,10-13H,4-5,9,14H2,1-3H3,(H2,26,31,32)
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n/an/an/an/a 5.5n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406523
PNG
(4-({5-[6-butyl-5- (2,6- dimethoxyphenyl)- 2,4- dih...)
Show SMILES CCCCc1nc(O)c(-c2nnc(CN3CCOCC3=O)o2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C24H28N4O7/c1-4-5-7-14-19(20-15(32-2)8-6-9-16(20)33-3)22(30)21(23(31)25-14)24-27-26-17(35-24)12-28-10-11-34-13-18(28)29/h6,8-9H,4-5,7,10-13H2,1-3H3,(H2,25,30,31)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406532
PNG
(5-(2,6- dimethoxyphenyl)- 6-(ethoxymethyl)- 3-{5-[...)
Show SMILES CCOCc1nc(O)c(-c2nnc(Cc3ccc(C)c(F)c3)o2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C26H26FN3O6/c1-5-35-13-17-21(22-18(33-3)7-6-8-19(22)34-4)24(31)23(25(32)28-17)26-30-29-20(36-26)12-15-10-9-14(2)16(27)11-15/h6-11H,5,12-13H2,1-4H3,(H2,28,31,32)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406546
PNG
(6-butyl-3-{5-[(3,4- difluorophenyl) methyl]-1,3,4-...)
Show SMILES CCCCc1nc(O)c(-c2nnc(Cc3ccc(F)c(F)c3)o2)c(O)c1-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C25H20F5N3O4/c1-2-3-7-18-20(14-5-4-6-15(12-14)37-25(28,29)30)22(34)21(23(35)31-18)24-33-32-19(36-24)11-13-8-9-16(26)17(27)10-13/h4-6,8-10,12H,2-3,7,11H2,1H3,(H2,31,34,35)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406552
PNG
(3-(2-butyl-5-{5- [(3,4- difluorophenyl) methyl]-1,...)
Show SMILES CCCCc1nc(O)c(-c2nnc(Cc3ccc(F)c(F)c3)o2)c(O)c1-c1cccc(COC)c1
Show InChI InChI=1S/C26H25F2N3O4/c1-3-4-8-20-22(17-7-5-6-16(11-17)14-34-2)24(32)23(25(33)29-20)26-31-30-21(35-26)13-15-9-10-18(27)19(28)12-15/h5-7,9-12H,3-4,8,13-14H2,1-2H3,(H2,29,32,33)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406558
PNG
(6-butyl-4-hydroxy- 3-{5-[(2-methyl- 1,3-thiazol-4-...)
Show SMILES CCCCc1[nH]c(=O)c(-c2nnc(Cc3csc(C)n3)o2)c(O)c1-c1cccc(c1)N1CCCC1
Show InChI InChI=1S/C26H29N5O3S/c1-3-4-10-20-22(17-8-7-9-19(13-17)31-11-5-6-12-31)24(32)23(25(33)28-20)26-30-29-21(34-26)14-18-15-35-16(2)27-18/h7-9,13,15H,3-6,10-12,14H2,1-2H3,(H2,28,32,33)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406562
PNG
(N-({5-[6-butyl-5- (2,6- dimethoxyphenyl)- 2,4- dih...)
Show SMILES CCCCc1nc(O)c(-c2nnc(CN(C)C(=O)c3ccncc3)o2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C27H29N5O6/c1-5-6-8-17-21(22-18(36-3)9-7-10-19(22)37-4)24(33)23(25(34)29-17)26-31-30-20(38-26)15-32(2)27(35)16-11-13-28-14-12-16/h7,9-14H,5-6,8,15H2,1-4H3,(H2,29,33,34)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406563
PNG
(N-({5-[6-butyl-5- (2,6- dimethoxyphenyl)- 2,4- dih...)
Show SMILES CCCCc1nc(O)c(-c2nnc(CNC(=O)c3cccnc3)o2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C26H27N5O6/c1-4-5-9-16-20(21-17(35-2)10-6-11-18(21)36-3)23(32)22(25(34)29-16)26-31-30-19(37-26)14-28-24(33)15-8-7-12-27-13-15/h6-8,10-13H,4-5,9,14H2,1-3H3,(H,28,33)(H2,29,32,34)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406572
PNG
(N-({5-[6-butyl-5- (2,6- dimethoxyphenyl)- 2,4- dih...)
Show SMILES CCCCc1nc(O)c(-c2nnc(CN(C)C(=O)C(C)(C)C)o2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C26H34N4O6/c1-8-9-11-15-19(20-16(34-6)12-10-13-17(20)35-7)22(31)21(23(32)27-15)24-29-28-18(36-24)14-30(5)25(33)26(2,3)4/h10,12-13H,8-9,11,14H2,1-7H3,(H2,27,31,32)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406573
PNG
(3-[5- (aminomethyl)- 1,3,4-oxadiazol-2- yl]-6-buty...)
Show SMILES CCCCc1nc(O)c(-c2nnc(CN)o2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C20H24N4O5/c1-4-5-7-11-15(16-12(27-2)8-6-9-13(16)28-3)18(25)17(19(26)22-11)20-24-23-14(10-21)29-20/h6,8-9H,4-5,7,10,21H2,1-3H3,(H2,22,25,26)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406574
PNG
(N-({5-[6-butyl-5- (2,6- dimethoxyphenyl)- 2,4- dih...)
Show SMILES CCCCc1nc(O)c(-c2nnc(CNC(=O)c3ccccc3)o2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C27H28N4O6/c1-4-5-12-17-21(22-18(35-2)13-9-14-19(22)36-3)24(32)23(26(34)29-17)27-31-30-20(37-27)15-28-25(33)16-10-7-6-8-11-16/h6-11,13-14H,4-5,12,15H2,1-3H3,(H,28,33)(H2,29,32,34)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406579
PNG
(N-({5-[6-butyl-5- (2,6- dimethoxyphenyl)- 2,4- dih...)
Show SMILES CCCCc1nc(O)c(-c2nnc(CNC(=O)C(F)(F)F)o2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C22H23F3N4O6/c1-4-5-7-11-15(16-12(33-2)8-6-9-13(16)34-3)18(30)17(19(31)27-11)20-29-28-14(35-20)10-26-21(32)22(23,24)25/h6,8-9H,4-5,7,10H2,1-3H3,(H,26,32)(H2,27,30,31)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406582
PNG
(2-{5-[6-butyl-5-(2,6- dimethoxyphenyl)- 2,4- dihyd...)
Show SMILES CCCCc1nc(O)c(-c2nnc(CC(N)=O)o2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C21H24N4O6/c1-4-5-7-11-16(17-12(29-2)8-6-9-13(17)30-3)19(27)18(20(28)23-11)21-25-24-15(31-21)10-14(22)26/h6,8-9H,4-5,7,10H2,1-3H3,(H2,22,26)(H2,23,27,28)
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n/an/an/an/a 55n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406612
PNG
(3-{5-[(4- chlorophenyl) methyl]-1,3,4- oxadiazol- ...)
Show SMILES CCOCc1nc(O)c(-c2nnc(Cc3ccc(Cl)cc3)o2)c(O)c1-c1c(OC)cc(F)cc1OC
Show InChI InChI=1S/C25H23ClFN3O6/c1-4-35-12-16-20(21-17(33-2)10-15(27)11-18(21)34-3)23(31)22(24(32)28-16)25-30-29-19(36-25)9-13-5-7-14(26)8-6-13/h5-8,10-11H,4,9,12H2,1-3H3,(H2,28,31,32)
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n/an/an/an/a 5.5n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406625
PNG
(3-{5-[(5-chloro-3- fluoropyridin-2- yl)methyl]-1,3...)
Show SMILES CCOCc1nc(O)c(-c2nnc(Cc3ncc(Cl)cc3F)o2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C24H22ClFN4O6/c1-4-35-11-15-19(20-16(33-2)6-5-7-17(20)34-3)22(31)21(23(32)28-15)24-30-29-18(36-24)9-14-13(26)8-12(25)10-27-14/h5-8,10H,4,9,11H2,1-3H3,(H2,28,31,32)
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n/an/an/an/a 5.5n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406419
PNG
(6-butyl-3-[5-(2- chlorophenyl)- 1,3,4-oxadiazol-2-...)
Show SMILES CCCCc1nc(O)c(-c2nnc(o2)-c2ccccc2Cl)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C25H24ClN3O5/c1-4-5-11-16-19(20-17(32-2)12-8-13-18(20)33-3)22(30)21(23(31)27-16)25-29-28-24(34-25)14-9-6-7-10-15(14)26/h6-10,12-13H,4-5,11H2,1-3H3,(H2,27,30,31)
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n/an/an/an/a 200n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406421
PNG
(6-butyl-5-(2,6- dimethoxyphenyl)- 3-[5-(1- phenylc...)
Show SMILES CCCCc1nc(O)c(-c2nnc(o2)C2(CC2)c2ccccc2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C28H29N3O5/c1-4-5-12-18-21(22-19(34-2)13-9-14-20(22)35-3)24(32)23(25(33)29-18)26-30-31-27(36-26)28(15-16-28)17-10-7-6-8-11-17/h6-11,13-14H,4-5,12,15-16H2,1-3H3,(H2,29,32,33)
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n/an/an/an/a 55n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406425
PNG
(3-(5-benzyl-1,3,4- oxadiazol-2-yl)-6- (but-3-en-1-...)
Show SMILES COc1cccc(OC)c1-c1c(CCC=C)nc(O)c(-c2nnc(Cc3ccccc3)o2)c1O
Show InChI InChI=1S/C26H25N3O5/c1-4-5-12-17-21(22-18(32-2)13-9-14-19(22)33-3)24(30)23(25(31)27-17)26-29-28-20(34-26)15-16-10-7-6-8-11-16/h4,6-11,13-14H,1,5,12,15H2,2-3H3,(H2,27,30,31)
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n/an/an/an/a 55n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406435
PNG
(6-butyl-5-(2,6- dimethoxyphenyl)- 3-{5-[2-(5-pheny...)
Show SMILES CCCCc1nc(O)c(-c2nnc(CCc3ncc(o3)-c3ccccc3)o2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C30H30N4O6/c1-4-5-12-19-25(26-20(37-2)13-9-14-21(26)38-3)28(35)27(29(36)32-19)30-34-33-24(40-30)16-15-23-31-17-22(39-23)18-10-7-6-8-11-18/h6-11,13-14,17H,4-5,12,15-16H2,1-3H3,(H2,32,35,36)
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n/an/an/an/a 55n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406438
PNG
(6-butyl-3-{5-[2-(4- chlorophenyl) propan-2-yl]-1,3...)
Show SMILES CCCCc1nc(O)c(-c2nnc(o2)C(C)(C)c2ccc(Cl)cc2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C28H30ClN3O5/c1-6-7-9-18-21(22-19(35-4)10-8-11-20(22)36-5)24(33)23(25(34)30-18)26-31-32-27(37-26)28(2,3)16-12-14-17(29)15-13-16/h8,10-15H,6-7,9H2,1-5H3,(H2,30,33,34)
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n/an/an/an/a 5.5n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406439
PNG
(6-butyl-5-(2,6- dimethoxyphenyl)- 3-{5-[(4- fluoro...)
Show SMILES CCCCc1nc(O)c(-c2nnc(Cc3ccc(F)cc3)o2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C26H26FN3O5/c1-4-5-7-17-21(22-18(33-2)8-6-9-19(22)34-3)24(31)23(25(32)28-17)26-30-29-20(35-26)14-15-10-12-16(27)13-11-15/h6,8-13H,4-5,7,14H2,1-3H3,(H2,28,31,32)
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n/an/an/an/a 5.5n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406450
PNG
(6-butyl-5-(2,6- dimethoxyphenyl)- 3-[5-(1H-indazol...)
Show SMILES CCCCc1nc(O)c(-c2nnc(Cc3n[nH]c4ccccc34)o2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C27H27N5O5/c1-4-5-10-17-22(23-19(35-2)12-8-13-20(23)36-3)25(33)24(26(34)28-17)27-32-31-21(37-27)14-18-15-9-6-7-11-16(15)29-30-18/h6-9,11-13H,4-5,10,14H2,1-3H3,(H,29,30)(H2,28,33,34)
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n/an/an/an/a 5.5n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406453
PNG
(6-butyl-5-(2,6- dimethoxyphenyl)- 3-{5-[(2-phenyl-...)
Show SMILES CCCCc1nc(O)c(-c2nnc(Cc3csc(n3)-c3ccccc3)o2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C29H28N4O5S/c1-4-5-12-19-23(24-20(36-2)13-9-14-21(24)37-3)26(34)25(27(35)31-19)28-33-32-22(38-28)15-18-16-39-29(30-18)17-10-7-6-8-11-17/h6-11,13-14,16H,4-5,12,15H2,1-3H3,(H2,31,34,35)
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n/an/an/an/a 5.5n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406464
PNG
(6-butyl-5-(2,6- dimethoxyphenyl)- 3-(5-{[3-fluoro-...)
Show SMILES CCCCc1nc(O)c(-c2nnc(Cc3cc(F)cc(c3)C(F)(F)F)o2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C27H25F4N3O5/c1-4-5-7-17-21(22-18(37-2)8-6-9-19(22)38-3)24(35)23(25(36)32-17)26-34-33-20(39-26)12-14-10-15(27(29,30)31)13-16(28)11-14/h6,8-11,13H,4-5,7,12H2,1-3H3,(H2,32,35,36)
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n/an/an/an/a 55n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406470
PNG
(6-butyl-5-(2,6- dimethoxyphenyl)- 3-{5-[(2-methyl-...)
Show SMILES CCCCc1nc(O)c(-c2nnc(Cc3nnn(C)n3)o2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C22H25N7O5/c1-5-6-8-12-17(18-13(32-3)9-7-10-14(18)33-4)20(30)19(21(31)23-12)22-26-25-16(34-22)11-15-24-28-29(2)27-15/h7,9-10H,5-6,8,11H2,1-4H3,(H2,23,30,31)
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n/an/an/an/a 5.5n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406473
PNG
(6-butyl-5-(2,6- dimethoxyphenyl)- 3-{5-[(5-phenyl-...)
Show SMILES CCCCc1nc(O)c(-c2nnc(Cc3nnc([nH]3)-c3ccccc3)o2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C28H28N6O5/c1-4-5-12-17-22(23-18(37-2)13-9-14-19(23)38-3)25(35)24(27(36)29-17)28-34-32-21(39-28)15-20-30-26(33-31-20)16-10-7-6-8-11-16/h6-11,13-14H,4-5,12,15H2,1-3H3,(H2,29,35,36)(H,30,31,33)
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n/an/an/an/a 5.5n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406491
PNG
(6-butyl-5-(2,6- dimethoxyphenyl)- 3-{5-[(5-methyl-...)
Show SMILES CCCCc1nc(O)c(-c2nnc(Cc3nc(sc3C)-c3ccccc3)o2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C30H30N4O5S/c1-5-6-13-19-24(25-21(37-3)14-10-15-22(25)38-4)27(35)26(28(36)31-19)29-34-33-23(39-29)16-20-17(2)40-30(32-20)18-11-8-7-9-12-18/h7-12,14-15H,5-6,13,16H2,1-4H3,(H2,31,35,36)
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n/an/an/an/a 5.5n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406492
PNG
(6-butyl-3-{5-[2- (3,4- dichlorophenyl) ethyl]-1,3,...)
Show SMILES CCCCc1nc(O)c(-c2nnc(CCc3ccc(Cl)c(Cl)c3)o2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C27H27Cl2N3O5/c1-4-5-7-18-22(23-19(35-2)8-6-9-20(23)36-3)25(33)24(26(34)30-18)27-32-31-21(37-27)13-11-15-10-12-16(28)17(29)14-15/h6,8-10,12,14H,4-5,7,11,13H2,1-3H3,(H2,30,33,34)
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n/an/an/an/a 55n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406496
PNG
(3-[5-(1,2- benzoxazol-3- ylmethyl)-1,3,4- oxadiazo...)
Show SMILES CCCCc1nc(O)c(-c2nnc(Cc3noc4ccccc34)o2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C27H26N4O6/c1-4-5-10-16-22(23-19(34-2)12-8-13-20(23)35-3)25(32)24(26(33)28-16)27-30-29-21(36-27)14-17-15-9-6-7-11-18(15)37-31-17/h6-9,11-13H,4-5,10,14H2,1-3H3,(H2,28,32,33)
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n/an/an/an/a 5.5n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406500
PNG
(3-{5-[(4- chlorophenyl) methyl]-1,3,4- oxadiazol-2...)
Show SMILES COc1cccc(OC)c1-c1c(O)c(-c2nnc(Cc3ccc(Cl)cc3)o2)c(O)nc1C1CC1
Show InChI InChI=1S/C25H22ClN3O5/c1-32-16-4-3-5-17(33-2)19(16)20-22(14-8-9-14)27-24(31)21(23(20)30)25-29-28-18(34-25)12-13-6-10-15(26)11-7-13/h3-7,10-11,14H,8-9,12H2,1-2H3,(H2,27,30,31)
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n/an/an/an/a 55n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406514
PNG
(3-{5-[(3-benzyl- 1,2,4-oxadiazol-5- yl)methyl]-1,3...)
Show SMILES CCCCc1nc(O)c(-c2nnc(Cc3nc(Cc4ccccc4)no3)o2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C29H29N5O6/c1-4-5-12-18-24(25-19(37-2)13-9-14-20(25)38-3)27(35)26(28(36)30-18)29-33-32-23(39-29)16-22-31-21(34-40-22)15-17-10-7-6-8-11-17/h6-11,13-14H,4-5,12,15-16H2,1-3H3,(H2,30,35,36)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406517
PNG
(6-butyl-5-(2,6- dimethoxyphenyl)- 3-{5-[(3-phenyl-...)
Show SMILES CCCCc1nc(O)c(-c2nnc(Cc3nc(no3)-c3ccccc3)o2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C28H27N5O6/c1-4-5-12-17-22(23-18(36-2)13-9-14-19(23)37-3)25(34)24(27(35)29-17)28-32-31-21(38-28)15-20-30-26(33-39-20)16-10-7-6-8-11-16/h6-11,13-14H,4-5,12,15H2,1-3H3,(H2,29,34,35)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406533
PNG
(3-{5-[(5- chloropyridin-2- yl)methyl]-1,3,4- oxadi...)
Show SMILES CCOCc1nc(O)c(-c2nnc(Cc3ccc(Cl)cn3)o2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C24H23ClN4O6/c1-4-34-12-15-19(20-16(32-2)6-5-7-17(20)33-3)22(30)21(23(31)27-15)24-29-28-18(35-24)10-14-9-8-13(25)11-26-14/h5-9,11H,4,10,12H2,1-3H3,(H2,27,30,31)
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n/an/an/an/a 5.5n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406556
PNG
(6-butyl-4-hydroxy- 5-(3- methoxyphenyl)-3- {5-[(2-...)
Show SMILES CCCCc1[nH]c(=O)c(-c2nnc(Cc3csc(C)n3)o2)c(O)c1-c1cccc(c1)C(C)C
Show InChI InChI=1S/C25H28N4O3S/c1-5-6-10-19-21(17-9-7-8-16(11-17)14(2)3)23(30)22(24(31)27-19)25-29-28-20(32-25)12-18-13-33-15(4)26-18/h7-9,11,13-14H,5-6,10,12H2,1-4H3,(H2,27,30,31)
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n/an/an/an/a 5.5n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406557
PNG
(6-butyl-4-hydroxy- 5-[3- (hydroxymethyl) phenyl]-3...)
Show SMILES CCCCc1[nH]c(=O)c(-c2nnc(Cc3csc(C)n3)o2)c(O)c1-c1cccc(c1)C1CC1
Show InChI InChI=1S/C25H26N4O3S/c1-3-4-8-19-21(17-7-5-6-16(11-17)15-9-10-15)23(30)22(24(31)27-19)25-29-28-20(32-25)12-18-13-33-14(2)26-18/h5-7,11,13,15H,3-4,8-10,12H2,1-2H3,(H2,27,30,31)
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n/an/an/an/a 55n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406565
PNG
(N-({5-[6-butyl-5- (2,6- dimethoxyphenyl)- 2,4- dih...)
Show SMILES CCCCc1nc(O)c(-c2nnc(CNC(=O)c3cccc(Cl)c3)o2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C27H27ClN4O6/c1-4-5-10-17-21(22-18(36-2)11-7-12-19(22)37-3)24(33)23(26(35)30-17)27-32-31-20(38-27)14-29-25(34)15-8-6-9-16(28)13-15/h6-9,11-13H,4-5,10,14H2,1-3H3,(H,29,34)(H2,30,33,35)
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n/an/an/an/a 5.5n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406577
PNG
(N-({5-[6-butyl-5- (2,6- dimethoxyphenyl)- 2,4- dih...)
Show SMILES CCCCc1nc(O)c(-c2nnc(CNC(=O)CC(C)C)o2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C25H32N4O6/c1-6-7-9-15-20(21-16(33-4)10-8-11-17(21)34-5)23(31)22(24(32)27-15)25-29-28-19(35-25)13-26-18(30)12-14(2)3/h8,10-11,14H,6-7,9,12-13H2,1-5H3,(H,26,30)(H2,27,31,32)
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n/an/an/an/a 5.5n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406586
PNG
(4-(2-{5-[6-butyl-5- (2,6- dimethoxyphenyl)- 2,4- d...)
Show SMILES CCCCc1nc(O)c(-c2nnc(CC(=O)N3CCNC(=O)C3)o2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C25H29N5O7/c1-4-5-7-14-20(21-15(35-2)8-6-9-16(21)36-3)23(33)22(24(34)27-14)25-29-28-18(37-25)12-19(32)30-11-10-26-17(31)13-30/h6,8-9H,4-5,7,10-13H2,1-3H3,(H,26,31)(H2,27,33,34)
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n/an/an/an/a 5.5n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406600
PNG
(2-{5-[6-butyl-5- (2,6- dimethoxyphenyl)- 2,4- dihy...)
Show SMILES CCCCCNC(=O)Cc1nnc(o1)-c1c(O)nc(CCCC)c(c1O)-c1c(OC)cccc1OC
Show InChI InChI=1S/C26H34N4O6/c1-5-7-9-14-27-19(31)15-20-29-30-26(36-20)23-24(32)21(16(11-8-6-2)28-25(23)33)22-17(34-3)12-10-13-18(22)35-4/h10,12-13H,5-9,11,14-15H2,1-4H3,(H,27,31)(H2,28,32,33)
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n/an/an/an/a 55n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406613
PNG
(1-({5-[6- (ethoxymethyl)-5- (4-fluoro-2,6- dimetho...)
Show SMILES CCOCc1nc(O)c(-c2nnc(CN3CCCC3=O)o2)c(O)c1-c1c(OC)cc(F)cc1OC
Show InChI InChI=1S/C23H25FN4O7/c1-4-34-11-13-18(19-14(32-2)8-12(24)9-15(19)33-3)21(30)20(22(31)25-13)23-27-26-16(35-23)10-28-7-5-6-17(28)29/h8-9H,4-7,10-11H2,1-3H3,(H2,25,30,31)
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n/an/an/an/a 55n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406619
PNG
(5-(2,6- dimethoxyphenyl)- 6-(ethoxymethyl)- 3-(5- ...)
Show SMILES CCOCc1nc(O)c(-c2nnc(Cc3noc4cccnc34)o2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C25H23N5O7/c1-4-35-12-14-19(20-15(33-2)7-5-8-16(20)34-3)23(31)21(24(32)27-14)25-29-28-18(36-25)11-13-22-17(37-30-13)9-6-10-26-22/h5-10H,4,11-12H2,1-3H3,(H2,27,31,32)
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n/an/an/an/a 5.5n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406620
PNG
(3-{5-[(5- chloropyridin-2- yl)methyl]-1,3,4- thiad...)
Show SMILES CCOCc1nc(O)c(-c2nnc(Cc3ccc(Cl)cn3)s2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C24H23ClN4O5S/c1-4-34-12-15-19(20-16(32-2)6-5-7-17(20)33-3)22(30)21(23(31)27-15)24-29-28-18(35-24)10-14-9-8-13(25)11-26-14/h5-9,11H,4,10,12H2,1-3H3,(H2,27,30,31)
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n/an/an/an/a 5.5n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406621
PNG
(3-{5-[(5- chloropyridin-2- yl)methyl]-1,3,4- thiad...)
Show SMILES COc1cccc(OC)c1-c1c(O)c(-c2nnc(Cc3ccc(Cl)cn3)s2)c(O)nc1C1CCCC1
Show InChI InChI=1S/C26H25ClN4O4S/c1-34-17-8-5-9-18(35-2)20(17)21-23(14-6-3-4-7-14)29-25(33)22(24(21)32)26-31-30-19(36-26)12-16-11-10-15(27)13-28-16/h5,8-11,13-14H,3-4,6-7,12H2,1-2H3,(H2,29,32,33)
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n/an/an/an/a 55n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406623
PNG
(N-({5-[5-(2,6- dimethoxyphenyl)- 6-(ethoxymethyl)-...)
Show SMILES CCOCc1nc(O)c(-c2nnc(CNC(=O)c3ccccn3)s2)c(O)c1-c1c(OC)cccc1OC
Show InChI InChI=1S/C25H25N5O6S/c1-4-36-13-15-19(20-16(34-2)9-7-10-17(20)35-3)22(31)21(24(33)28-15)25-30-29-18(37-25)12-27-23(32)14-8-5-6-11-26-14/h5-11H,4,12-13H2,1-3H3,(H,27,32)(H2,28,31,33)
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n/an/an/an/a 55n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM406627
PNG
(3-{5-[(4- chlorophenyl) methyl]- 1,3,4-oxadiazol- ...)
Show SMILES COc1cccc(OC)c1-c1c(O)c(-c2nnc(Cc3ccc(Cl)cc3)o2)c(O)nc1C1CCCC1
Show InChI InChI=1S/C27H26ClN3O5/c1-34-18-8-5-9-19(35-2)21(18)22-24(16-6-3-4-7-16)29-26(33)23(25(22)32)27-31-30-20(36-27)14-15-10-12-17(28)13-11-15/h5,8-13,16H,3-4,6-7,14H2,1-2H3,(H2,29,32,33)
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n/an/an/an/a 5.5n/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ...


US Patent US10336739 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NFD
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%