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Patent code US10336741

Compile Data Set for Download or QSAR
Found 56 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Coagulation factor XI


(Homo sapiens (Human))
BDBM294112
PNG
(US10336741, Example 99 | US9585881, Example 99 | m...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)C1CCN(CC1)C(N)=N)N1CCN(CC1)S(C)(=O)=O
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n/an/a 1.20n/an/an/an/an/an/a



Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM238259
PNG
(US10336741, Example 71 | US9394250, 71 | US9585881...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)C1CCN(CC1)C(N)=N)C1CCN(CC1)S(C)(=O)=O
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM238268
PNG
(US10336741, Example 98 | US9394250, 98 | US9585881...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)[C@@H]1C[C@@H](CN1C(=O)C1CCN(CC1)C(N)=N)N1CCN(CC1)S(C)(=O)=O
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM238252
PNG
(US10336741, Example 20 | US9394250, 20 | US9585881...)
Show SMILES CS(=O)(=O)N1CCN(CC1)[C@H]1C[C@H](N(C1)C(=O)c1ccc(cc1)C(N)=N)C(=O)Nc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H30N6O6S/c1-38(36,37)30-12-10-29(11-13-30)20-14-21(23(32)28-19-8-6-18(7-9-19)25(34)35)31(15-20)24(33)17-4-2-16(3-5-17)22(26)27/h2-9,20-21H,10-15H2,1H3,(H3,26,27)(H,28,32)(H,34,35)/t20-,21-/m0/s1
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM406677
PNG
(US10336741, Example 96)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)C1CC[C@H](CN)CC1)C1CCN(CC1)S(C)(=O)=O
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM238260
PNG
(US10336741, Example 73 | US9394250, 73 | US9585881...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)[C@@H]1C[C@@H](CN1C(=O)c1ccc(cc1)C(N)=N)C1CCN(CC1)S(C)(=O)=O
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n/an/a 4.40n/an/an/an/an/an/a



Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM238265
PNG
(US10336741, Example 94 | US9394250, 94 | US9585881...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1)C1CCN(CC1)S(C)(=O)=O
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n/an/a 5.40n/an/an/an/an/an/a



Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM238263
PNG
(US10336741, Example 88 | US9394250, 88 | US9585881...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)N1CCN(CC1)C(N)=N)C1CCN(CC1)S(C)(=O)=O
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM238261
PNG
(US10336741, Example 79 | US9394250, 79 | US9585881...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)c1ccc(NC(N)=N)cc1)C1CCN(CC1)S(C)(=O)=O
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n/an/a 6.5n/an/an/an/an/an/a



Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM238268
PNG
(US10336741, Example 98 | US9394250, 98 | US9585881...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)[C@@H]1C[C@@H](CN1C(=O)C1CCN(CC1)C(N)=N)N1CCN(CC1)S(C)(=O)=O
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM238269
PNG
(US10336741, Example 111 | US9394250, 111)
Show SMILES CS(=O)(=O)N1CCC(CC1)[C@H]1C[C@H](N(C1)C(=O)c1ccc(cc1)C(N)=N)C(=O)Nc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C26H31N5O6S/c1-38(36,37)30-12-10-16(11-13-30)20-14-22(24(32)29-21-8-6-19(7-9-21)26(34)35)31(15-20)25(33)18-4-2-17(3-5-18)23(27)28/h2-9,16,20,22H,10-15H2,1H3,(H3,27,28)(H,29,32)(H,34,35)/t20-,22-/m0/s1
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM294104
PNG
(US10336741, Example 86 | US9585881, Example 86 | m...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)[C@H]1CC[C@@H](CC1)[C@H](C)N)C1CCN(CC1)S(C)(=O)=O
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM238255
PNG
(US10336741, Example 43 | US9394250, 43 | US9585881...)
Show SMILES Clc1ccc(c(\C=C\C(=O)N2C[C@H](C[C@H]2C(=O)Nc2ccc3nn[nH]c3c2)N2CCOCC2)c1)-n1cnnn1
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM238253
PNG
(US10336741, Example 37 | US9394250, 37 | US9585881...)
Show SMILES OC(=O)c1ccc(NC(=O)[C@@H]2C[C@@H](CN2C(=O)\C=C\c2cc(Cl)ccc2-n2cnnn2)N2CCOCC2)cc1
Show InChI InChI=1S/C26H26ClN7O5/c27-19-4-7-22(34-16-28-30-31-34)18(13-19)3-8-24(35)33-15-21(32-9-11-39-12-10-32)14-23(33)25(36)29-20-5-1-17(2-6-20)26(37)38/h1-8,13,16,21,23H,9-12,14-15H2,(H,29,36)(H,37,38)/b8-3+/t21-,23-/m0/s1
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM238256
PNG
(US10336741, Example 55 | US9394250, 55 | US9585881...)
Show SMILES NC[C@H]1CC[C@@H](CC1)C(=O)N1C[C@H](C[C@H]1C(=O)Nc1ccc(cc1)C(O)=O)N1CCN(CC1)S(=O)(=O)C1CC1
Show InChI InChI=1S/C27H39N5O6S/c28-16-18-1-3-19(4-2-18)26(34)32-17-22(30-11-13-31(14-12-30)39(37,38)23-9-10-23)15-24(32)25(33)29-21-7-5-20(6-8-21)27(35)36/h5-8,18-19,22-24H,1-4,9-17,28H2,(H,29,33)(H,35,36)/t18-,19-,22-,24-/m0/s1
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM238251
PNG
(US10336741, Example 9 | US9394250, 9 | US9585881, ...)
Show SMILES CS(=O)(=O)N1CCN(CC1)[C@H]1C[C@H](N(C1)C(=O)C1CCN(CC1)C(N)=N)C(=O)Nc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H35N7O6S/c1-38(36,37)30-12-10-28(11-13-30)19-14-20(21(32)27-18-4-2-17(3-5-18)23(34)35)31(15-19)22(33)16-6-8-29(9-7-16)24(25)26/h2-5,16,19-20H,6-15H2,1H3,(H3,25,26)(H,27,32)(H,34,35)/t19-,20-/m0/s1
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM238264
PNG
(US10336741, Example 93 | US9394250, 93 | US9585881...)
Show SMILES Cn1cc(Cl)c2c(F)c(ccc12)C(=O)N1C[C@H](C[C@H]1C(=O)Nc1ccc(cc1)C(O)=O)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C28H30ClFN4O6S/c1-32-15-21(29)24-22(32)8-7-20(25(24)30)27(36)34-14-18(16-9-11-33(12-10-16)41(2,39)40)13-23(34)26(35)31-19-5-3-17(4-6-19)28(37)38/h3-8,15-16,18,23H,9-14H2,1-2H3,(H,31,35)(H,37,38)/t18-,23-/m0/s1
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM238257
PNG
(US10336741, Example 57 | US9394250, 57 | US9585881...)
Show SMILES C[C@H]1CN(CCN1S(N)(=O)=O)[C@H]1C[C@H](N(C1)C(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C26H30ClN9O4S/c1-18-15-33(11-12-36(18)41(28,39)40)22-14-24(26(38)30-21-5-3-2-4-6-21)34(16-22)25(37)10-7-19-13-20(27)8-9-23(19)35-17-29-31-32-35/h2-10,13,17-18,22,24H,11-12,14-16H2,1H3,(H,30,38)(H2,28,39,40)/b10-7+/t18-,22-,24-/m0/s1
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n/an/a 27n/an/an/an/an/an/a



Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Coagulation factor XI


(Homo sapiens (Human))
BDBM406666
PNG
(US10336741, Example 39)
Show SMILES Clc1ccc(c(\C=C\C(=O)C2C[C@H](C[C@H]2C(=O)Nc2ccccc2)N2CCN(CC2)S(=O)(=O)c2ccccc2)c1)-n1cnnn1
Show InChI InChI=1S/C32H32ClN7O4S/c33-24-12-13-30(40-22-34-36-37-40)23(19-24)11-14-31(41)28-20-26(21-29(28)32(42)35-25-7-3-1-4-8-25)38-15-17-39(18-16-38)45(43,44)27-9-5-2-6-10-27/h1-14,19,22,26,28-29H,15-18,20-21H2,(H,35,42)/b14-11+/t26-,28?,29-/m1/s1
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n/an/a 78n/an/an/an/an/an/a



Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM238265
PNG
(US10336741, Example 94 | US9394250, 94 | US9585881...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1)C1CCN(CC1)S(C)(=O)=O
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n/an/a>3.30E+4n/an/an/an/an/an/a



Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM238265
PNG
(US10336741, Example 94 | US9394250, 94 | US9585881...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1)C1CCN(CC1)S(C)(=O)=O
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM238260
PNG
(US10336741, Example 73 | US9394250, 73 | US9585881...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)[C@@H]1C[C@@H](CN1C(=O)c1ccc(cc1)C(N)=N)C1CCN(CC1)S(C)(=O)=O
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n/an/a 3.70E+4n/an/an/an/an/an/a



Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM238261
PNG
(US10336741, Example 79 | US9394250, 79 | US9585881...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)c1ccc(NC(N)=N)cc1)C1CCN(CC1)S(C)(=O)=O
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n/an/a 4.00E+4n/an/an/an/an/an/a



Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM238263
PNG
(US10336741, Example 88 | US9394250, 88 | US9585881...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)N1CCN(CC1)C(N)=N)C1CCN(CC1)S(C)(=O)=O
PDB

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n/an/a 5.70E+4n/an/an/an/an/an/a



Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM294112
PNG
(US10336741, Example 99 | US9585881, Example 99 | m...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)C1CCN(CC1)C(N)=N)N1CCN(CC1)S(C)(=O)=O
PDB

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n/an/a 8.40E+4n/an/an/an/an/an/a



Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM238259
PNG
(US10336741, Example 71 | US9394250, 71 | US9585881...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)C1CCN(CC1)C(N)=N)C1CCN(CC1)S(C)(=O)=O
PDB

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n/an/a 9.40E+4n/an/an/an/an/an/a



Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM406677
PNG
(US10336741, Example 96)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)C1CC[C@H](CN)CC1)C1CCN(CC1)S(C)(=O)=O
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM238268
PNG
(US10336741, Example 98 | US9394250, 98 | US9585881...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)[C@@H]1C[C@@H](CN1C(=O)C1CCN(CC1)C(N)=N)N1CCN(CC1)S(C)(=O)=O
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM238259
PNG
(US10336741, Example 71 | US9394250, 71 | US9585881...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)C1CCN(CC1)C(N)=N)C1CCN(CC1)S(C)(=O)=O
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM238268
PNG
(US10336741, Example 98 | US9394250, 98 | US9585881...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)[C@@H]1C[C@@H](CN1C(=O)C1CCN(CC1)C(N)=N)N1CCN(CC1)S(C)(=O)=O
PDB

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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM238251
PNG
(US10336741, Example 9 | US9394250, 9 | US9585881, ...)
Show SMILES CS(=O)(=O)N1CCN(CC1)[C@H]1C[C@H](N(C1)C(=O)C1CCN(CC1)C(N)=N)C(=O)Nc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H35N7O6S/c1-38(36,37)30-12-10-28(11-13-30)19-14-20(21(32)27-18-4-2-17(3-5-18)23(34)35)31(15-19)22(33)16-6-8-29(9-7-16)24(25)26/h2-5,16,19-20H,6-15H2,1H3,(H3,25,26)(H,27,32)(H,34,35)/t19-,20-/m0/s1
PDB

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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM238255
PNG
(US10336741, Example 43 | US9394250, 43 | US9585881...)
Show SMILES Clc1ccc(c(\C=C\C(=O)N2C[C@H](C[C@H]2C(=O)Nc2ccc3nn[nH]c3c2)N2CCOCC2)c1)-n1cnnn1
PDB

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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM238269
PNG
(US10336741, Example 111 | US9394250, 111)
Show SMILES CS(=O)(=O)N1CCC(CC1)[C@H]1C[C@H](N(C1)C(=O)c1ccc(cc1)C(N)=N)C(=O)Nc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C26H31N5O6S/c1-38(36,37)30-12-10-16(11-13-30)20-14-22(24(32)29-21-8-6-19(7-9-21)26(34)35)31(15-20)25(33)18-4-2-17(3-5-18)23(27)28/h2-9,16,20,22H,10-15H2,1H3,(H3,27,28)(H,29,32)(H,34,35)/t20-,22-/m0/s1
PDB

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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM238251
PNG
(US10336741, Example 9 | US9394250, 9 | US9585881, ...)
Show SMILES CS(=O)(=O)N1CCN(CC1)[C@H]1C[C@H](N(C1)C(=O)C1CCN(CC1)C(N)=N)C(=O)Nc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H35N7O6S/c1-38(36,37)30-12-10-28(11-13-30)19-14-20(21(32)27-18-4-2-17(3-5-18)23(34)35)31(15-19)22(33)16-6-8-29(9-7-16)24(25)26/h2-5,16,19-20H,6-15H2,1H3,(H3,25,26)(H,27,32)(H,34,35)/t19-,20-/m0/s1
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM238260
PNG
(US10336741, Example 73 | US9394250, 73 | US9585881...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)[C@@H]1C[C@@H](CN1C(=O)c1ccc(cc1)C(N)=N)C1CCN(CC1)S(C)(=O)=O
PDB
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM406677
PNG
(US10336741, Example 96)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)C1CC[C@H](CN)CC1)C1CCN(CC1)S(C)(=O)=O
PDB

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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM238257
PNG
(US10336741, Example 57 | US9394250, 57 | US9585881...)
Show SMILES C[C@H]1CN(CCN1S(N)(=O)=O)[C@H]1C[C@H](N(C1)C(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C26H30ClN9O4S/c1-18-15-33(11-12-36(18)41(28,39)40)22-14-24(26(38)30-21-5-3-2-4-6-21)34(16-22)25(37)10-7-19-13-20(27)8-9-23(19)35-17-29-31-32-35/h2-10,13,17-18,22,24H,11-12,14-16H2,1H3,(H,30,38)(H2,28,39,40)/b10-7+/t18-,22-,24-/m0/s1
PDB
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM238264
PNG
(US10336741, Example 93 | US9394250, 93 | US9585881...)
Show SMILES Cn1cc(Cl)c2c(F)c(ccc12)C(=O)N1C[C@H](C[C@H]1C(=O)Nc1ccc(cc1)C(O)=O)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C28H30ClFN4O6S/c1-32-15-21(29)24-22(32)8-7-20(25(24)30)27(36)34-14-18(16-9-11-33(12-10-16)41(2,39)40)13-23(34)26(35)31-19-5-3-17(4-6-19)28(37)38/h3-8,15-16,18,23H,9-14H2,1-2H3,(H,31,35)(H,37,38)/t18-,23-/m0/s1
PDB

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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM238253
PNG
(US10336741, Example 37 | US9394250, 37 | US9585881...)
Show SMILES OC(=O)c1ccc(NC(=O)[C@@H]2C[C@@H](CN2C(=O)\C=C\c2cc(Cl)ccc2-n2cnnn2)N2CCOCC2)cc1
Show InChI InChI=1S/C26H26ClN7O5/c27-19-4-7-22(34-16-28-30-31-34)18(13-19)3-8-24(35)33-15-21(32-9-11-39-12-10-32)14-23(33)25(36)29-20-5-1-17(2-6-20)26(37)38/h1-8,13,16,21,23H,9-12,14-15H2,(H,29,36)(H,37,38)/b8-3+/t21-,23-/m0/s1
PDB

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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM238253
PNG
(US10336741, Example 37 | US9394250, 37 | US9585881...)
Show SMILES OC(=O)c1ccc(NC(=O)[C@@H]2C[C@@H](CN2C(=O)\C=C\c2cc(Cl)ccc2-n2cnnn2)N2CCOCC2)cc1
Show InChI InChI=1S/C26H26ClN7O5/c27-19-4-7-22(34-16-28-30-31-34)18(13-19)3-8-24(35)33-15-21(32-9-11-39-12-10-32)14-23(33)25(36)29-20-5-1-17(2-6-20)26(37)38/h1-8,13,16,21,23H,9-12,14-15H2,(H,29,36)(H,37,38)/b8-3+/t21-,23-/m0/s1
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM238255
PNG
(US10336741, Example 43 | US9394250, 43 | US9585881...)
Show SMILES Clc1ccc(c(\C=C\C(=O)N2C[C@H](C[C@H]2C(=O)Nc2ccc3nn[nH]c3c2)N2CCOCC2)c1)-n1cnnn1
PDB
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM294112
PNG
(US10336741, Example 99 | US9585881, Example 99 | m...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)C1CCN(CC1)C(N)=N)N1CCN(CC1)S(C)(=O)=O
PDB
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM238252
PNG
(US10336741, Example 20 | US9394250, 20 | US9585881...)
Show SMILES CS(=O)(=O)N1CCN(CC1)[C@H]1C[C@H](N(C1)C(=O)c1ccc(cc1)C(N)=N)C(=O)Nc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H30N6O6S/c1-38(36,37)30-12-10-29(11-13-30)20-14-21(23(32)28-19-8-6-18(7-9-19)25(34)35)31(15-20)24(33)17-4-2-16(3-5-17)22(26)27/h2-9,20-21H,10-15H2,1H3,(H3,26,27)(H,28,32)(H,34,35)/t20-,21-/m0/s1
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM406666
PNG
(US10336741, Example 39)
Show SMILES Clc1ccc(c(\C=C\C(=O)C2C[C@H](C[C@H]2C(=O)Nc2ccccc2)N2CCN(CC2)S(=O)(=O)c2ccccc2)c1)-n1cnnn1
Show InChI InChI=1S/C32H32ClN7O4S/c33-24-12-13-30(40-22-34-36-37-40)23(19-24)11-14-31(41)28-20-26(21-29(28)32(42)35-25-7-3-1-4-8-25)38-15-17-39(18-16-38)45(43,44)27-9-5-2-6-10-27/h1-14,19,22,26,28-29H,15-18,20-21H2,(H,35,42)/b14-11+/t26-,28?,29-/m1/s1
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM238263
PNG
(US10336741, Example 88 | US9394250, 88 | US9585881...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)N1CCN(CC1)C(N)=N)C1CCN(CC1)S(C)(=O)=O
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM294104
PNG
(US10336741, Example 86 | US9585881, Example 86 | m...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)[C@H]1CC[C@@H](CC1)[C@H](C)N)C1CCN(CC1)S(C)(=O)=O
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n/an/a>1.00E+5n/an/an/an/an/an/a



Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM294104
PNG
(US10336741, Example 86 | US9585881, Example 86 | m...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)[C@H]1CC[C@@H](CC1)[C@H](C)N)C1CCN(CC1)S(C)(=O)=O
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n/an/a>1.00E+5n/an/an/an/an/an/a



Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM238256
PNG
(US10336741, Example 55 | US9394250, 55 | US9585881...)
Show SMILES NC[C@H]1CC[C@@H](CC1)C(=O)N1C[C@H](C[C@H]1C(=O)Nc1ccc(cc1)C(O)=O)N1CCN(CC1)S(=O)(=O)C1CC1
Show InChI InChI=1S/C27H39N5O6S/c28-16-18-1-3-19(4-2-18)26(34)32-17-22(30-11-13-31(14-12-30)39(37,38)23-9-10-23)15-24(32)25(33)29-21-7-5-20(6-8-21)27(35)36/h5-8,18-19,22-24H,1-4,9-17,28H2,(H,29,33)(H,35,36)/t18-,19-,22-,24-/m0/s1
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM238257
PNG
(US10336741, Example 57 | US9394250, 57 | US9585881...)
Show SMILES C[C@H]1CN(CCN1S(N)(=O)=O)[C@H]1C[C@H](N(C1)C(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C26H30ClN9O4S/c1-18-15-33(11-12-36(18)41(28,39)40)22-14-24(26(38)30-21-5-3-2-4-6-21)34(16-22)25(37)10-7-19-13-20(27)8-9-23(19)35-17-29-31-32-35/h2-10,13,17-18,22,24H,11-12,14-16H2,1H3,(H,30,38)(H2,28,39,40)/b10-7+/t18-,22-,24-/m0/s1
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM238268
PNG
(US10336741, Example 98 | US9394250, 98 | US9585881...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)[C@@H]1C[C@@H](CN1C(=O)C1CCN(CC1)C(N)=N)N1CCN(CC1)S(C)(=O)=O
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM238256
PNG
(US10336741, Example 55 | US9394250, 55 | US9585881...)
Show SMILES NC[C@H]1CC[C@@H](CC1)C(=O)N1C[C@H](C[C@H]1C(=O)Nc1ccc(cc1)C(O)=O)N1CCN(CC1)S(=O)(=O)C1CC1
Show InChI InChI=1S/C27H39N5O6S/c28-16-18-1-3-19(4-2-18)26(34)32-17-22(30-11-13-31(14-12-30)39(37,38)23-9-10-23)15-24(32)25(33)29-21-7-5-20(6-8-21)27(35)36/h5-8,18-19,22-24H,1-4,9-17,28H2,(H,29,33)(H,35,36)/t18-,19-,22-,24-/m0/s1
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM238252
PNG
(US10336741, Example 20 | US9394250, 20 | US9585881...)
Show SMILES CS(=O)(=O)N1CCN(CC1)[C@H]1C[C@H](N(C1)C(=O)c1ccc(cc1)C(N)=N)C(=O)Nc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H30N6O6S/c1-38(36,37)30-12-10-29(11-13-30)20-14-21(23(32)28-19-8-6-18(7-9-19)25(34)35)31(15-20)24(33)17-4-2-16(3-5-17)22(26)27/h2-9,20-21H,10-15H2,1H3,(H3,26,27)(H,28,32)(H,34,35)/t20-,21-/m0/s1
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM238268
PNG
(US10336741, Example 98 | US9394250, 98 | US9585881...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)[C@@H]1C[C@@H](CN1C(=O)C1CCN(CC1)C(N)=N)N1CCN(CC1)S(C)(=O)=O
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM238261
PNG
(US10336741, Example 79 | US9394250, 79 | US9585881...)
Show SMILES COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)c1ccc(NC(N)=N)cc1)C1CCN(CC1)S(C)(=O)=O
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM406666
PNG
(US10336741, Example 39)
Show SMILES Clc1ccc(c(\C=C\C(=O)C2C[C@H](C[C@H]2C(=O)Nc2ccccc2)N2CCN(CC2)S(=O)(=O)c2ccccc2)c1)-n1cnnn1
Show InChI InChI=1S/C32H32ClN7O4S/c33-24-12-13-30(40-22-34-36-37-40)23(19-24)11-14-31(41)28-20-26(21-29(28)32(42)35-25-7-3-1-4-8-25)38-15-17-39(18-16-38)45(43,44)27-9-5-2-6-10-27/h1-14,19,22,26,28-29H,15-18,20-21H2,(H,35,42)/b14-11+/t26-,28?,29-/m1/s1
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Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM238264
PNG
(US10336741, Example 93 | US9394250, 93 | US9585881...)
Show SMILES Cn1cc(Cl)c2c(F)c(ccc12)C(=O)N1C[C@H](C[C@H]1C(=O)Nc1ccc(cc1)C(O)=O)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C28H30ClFN4O6S/c1-32-15-21(29)24-22(32)8-7-20(25(24)30)27(36)34-14-18(16-9-11-33(12-10-16)41(2,39)40)13-23(34)26(35)31-19-5-3-17(4-6-19)28(37)38/h3-8,15-16,18,23H,9-14H2,1-2H3,(H,31,35)(H,37,38)/t18-,23-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Ono Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibitory activities of compounds of the present invention against factor XIa, Xa, XIIa, IXa, VIIa, plasma kallikrein or thrombin were evaluated usi...


US Patent US10336741 (2019)


BindingDB Entry DOI: 10.7270/Q2CR5WQP
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%