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Patent code US10336755

Compile Data Set for Download or QSAR
Found 23 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM406681
PNG
(1-(4-(7-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridi...)
Show SMILES C=CC(=O)N1CCN(CC1)c1cc2cn[nH]c2c(n1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C25H23N5O2/c1-2-23(31)30-14-12-29(13-15-30)22-16-19-17-26-28-25(19)24(27-22)18-8-10-21(11-9-18)32-20-6-4-3-5-7-20/h2-11,16-17H,1,12-15H2,(H,26,28)
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n/an/a<100n/an/an/an/an/an/a



Beijing Innocare Pharma Tech Co., Ltd.

US Patent


Assay Description
In vitro activity of BTK is measured by detecting ADP produced in a kinase reaction with an ADP-Glo™ kinase assay kit from Promega Company. In the ki...


US Patent US10336755 (2019)


BindingDB Entry DOI: 10.7270/Q20G3NH5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM406684
PNG
(1-(4-(7-(4-(pyridin-2-oxy)phenyl)-1H-pyrazazo[3,4-...)
Show SMILES CC(=O)Nc1c(C)cc(nc1-c1ccc(OC2CCCC2)cc1)C1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C27H33N3O3/c1-4-25(32)30-15-13-20(14-16-30)24-17-18(2)26(28-19(3)31)27(29-24)21-9-11-23(12-10-21)33-22-7-5-6-8-22/h4,9-12,17,20,22H,1,5-8,13-16H2,2-3H3,(H,28,31)
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Beijing Innocare Pharma Tech Co., Ltd.

US Patent


Assay Description
In vitro activity of BTK is measured by detecting ADP produced in a kinase reaction with an ADP-Glo™ kinase assay kit from Promega Company. In the ki...


US Patent US10336755 (2019)


BindingDB Entry DOI: 10.7270/Q20G3NH5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM406686
PNG
(1-(4-(7-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4...)
Show SMILES Fc1cc(Oc2ccccc2)ccc1-c1nc(cc2cn[nH]c12)C1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C26H23FN4O2/c1-2-24(32)31-12-10-17(11-13-31)23-14-18-16-28-30-25(18)26(29-23)21-9-8-20(15-22(21)27)33-19-6-4-3-5-7-19/h2-9,14-17H,1,10-13H2,(H,28,30)
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Beijing Innocare Pharma Tech Co., Ltd.

US Patent


Assay Description
In vitro activity of BTK is measured by detecting ADP produced in a kinase reaction with an ADP-Glo™ kinase assay kit from Promega Company. In the ki...


US Patent US10336755 (2019)


BindingDB Entry DOI: 10.7270/Q20G3NH5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM406685
PNG
(1-(4-(7-(4-(pyridin-2-oxy)phenyl)-1H-pyrazolo[3,4-...)
Show SMILES CC(=O)Nc1c(C)cc(nc1-c1ccc(Oc2ccccn2)cc1)C1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C27H28N4O3/c1-4-25(33)31-15-12-20(13-16-31)23-17-18(2)26(29-19(3)32)27(30-23)21-8-10-22(11-9-21)34-24-7-5-6-14-28-24/h4-11,14,17,20H,1,12-13,15-16H2,2-3H3,(H,29,32)
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n/an/a<100n/an/an/an/an/an/a



Beijing Innocare Pharma Tech Co., Ltd.

US Patent


Assay Description
In vitro activity of BTK is measured by detecting ADP produced in a kinase reaction with an ADP-Glo™ kinase assay kit from Promega Company. In the ki...


US Patent US10336755 (2019)


BindingDB Entry DOI: 10.7270/Q20G3NH5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM406672
PNG
((E)-4-(dimethylamino)-1-(3-(7-(4-phenoxyphenyl)-1H...)
Show SMILES CN(C)C\C=C\C(=O)N1CCCC(C1)c1cc2cn[nH]c2c(n1)-c1ccc(Oc2ccccc2)cc1
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n/an/a<100n/an/an/an/an/an/a



Beijing Innocare Pharma Tech Co., Ltd.

US Patent


Assay Description
In vitro activity of BTK is measured by detecting ADP produced in a kinase reaction with an ADP-Glo™ kinase assay kit from Promega Company. In the ki...


US Patent US10336755 (2019)


BindingDB Entry DOI: 10.7270/Q20G3NH5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM406695
PNG
(US10336755, Example 22b)
Show SMILES C=CC(=O)N1CC[C@H](C1)c1cc2cn[nH]c2c(n1)-c1ccc(Oc2ccccc2)cc1
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n/an/a<100n/an/an/an/an/an/a



Beijing Innocare Pharma Tech Co., Ltd.

US Patent


Assay Description
In vitro activity of BTK is measured by detecting ADP produced in a kinase reaction with an ADP-Glo™ kinase assay kit from Promega Company. In the ki...


US Patent US10336755 (2019)


BindingDB Entry DOI: 10.7270/Q20G3NH5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM406674
PNG
(1-(3-(7-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridi...)
Show SMILES C=CC(=O)N1CCC(C1)c1cc2cn[nH]c2c(n1)-c1ccc(Oc2ccccc2)cc1
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n/an/a<100n/an/an/an/an/an/a



Beijing Innocare Pharma Tech Co., Ltd.

US Patent


Assay Description
In vitro activity of BTK is measured by detecting ADP produced in a kinase reaction with an ADP-Glo™ kinase assay kit from Promega Company. In the ki...


US Patent US10336755 (2019)


BindingDB Entry DOI: 10.7270/Q20G3NH5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM406680
PNG
(N-(3-(7-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridi...)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cc2cn[nH]c2c(n1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C27H20N4O2/c1-2-25(32)29-21-8-6-7-19(15-21)24-16-20-17-28-31-27(20)26(30-24)18-11-13-23(14-12-18)33-22-9-4-3-5-10-22/h2-17H,1H2,(H,28,31)(H,29,32)
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Beijing Innocare Pharma Tech Co., Ltd.

US Patent


Assay Description
In vitro activity of BTK is measured by detecting ADP produced in a kinase reaction with an ADP-Glo™ kinase assay kit from Promega Company. In the ki...


US Patent US10336755 (2019)


BindingDB Entry DOI: 10.7270/Q20G3NH5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM406682
PNG
(N-(1-(7-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridi...)
Show SMILES C=CC(=O)NC1CCN(C1)c1cc2cn[nH]c2c(n1)-c1ccc(Oc2ccccc2)cc1
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n/an/a<100n/an/an/an/an/an/a



Beijing Innocare Pharma Tech Co., Ltd.

US Patent


Assay Description
In vitro activity of BTK is measured by detecting ADP produced in a kinase reaction with an ADP-Glo™ kinase assay kit from Promega Company. In the ki...


US Patent US10336755 (2019)


BindingDB Entry DOI: 10.7270/Q20G3NH5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM406673
PNG
(7-(4-phenoxyphenyl)-5-(1-(ethenylsulfonyl)piperidi...)
Show SMILES C=CS(=O)(=O)N1CCCC(C1)c1cc2cn[nH]c2c(n1)-c1ccc(Oc2ccccc2)cc1
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Beijing Innocare Pharma Tech Co., Ltd.

US Patent


Assay Description
In vitro activity of BTK is measured by detecting ADP produced in a kinase reaction with an ADP-Glo™ kinase assay kit from Promega Company. In the ki...


US Patent US10336755 (2019)


BindingDB Entry DOI: 10.7270/Q20G3NH5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM406690
PNG
(4-(5-(1-acryloylpyrrolidin-3-yl)-1H-pyrazolo[3,4-c...)
Show SMILES C=CC(=O)N1CCC(C1)c1cc2cn[nH]c2c(n1)-c1ccc(cc1)C(=O)Nc1ccccn1
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n/an/a<100n/an/an/an/an/an/a



Beijing Innocare Pharma Tech Co., Ltd.

US Patent


Assay Description
In vitro activity of BTK is measured by detecting ADP produced in a kinase reaction with an ADP-Glo™ kinase assay kit from Promega Company. In the ki...


US Patent US10336755 (2019)


BindingDB Entry DOI: 10.7270/Q20G3NH5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM406671
PNG
(1-(3-(7-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridi...)
Show SMILES C=CC(=O)N1CCCC(C1)c1cc2cn[nH]c2c(n1)-c1ccc(Oc2ccccc2)cc1
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Beijing Innocare Pharma Tech Co., Ltd.

US Patent


Assay Description
In vitro activity of BTK is measured by detecting ADP produced in a kinase reaction with an ADP-Glo™ kinase assay kit from Promega Company. In the ki...


US Patent US10336755 (2019)


BindingDB Entry DOI: 10.7270/Q20G3NH5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM406687
PNG
(1-(4-(7-(4-(3-fluorophenoxyl)phenyl)-1H-pyrazolo[3...)
Show SMILES Fc1cccc(Oc2ccc(cc2)-c2nc(cc3cn[nH]c23)C2CCN(CC2)C(=O)C=C)c1
Show InChI InChI=1S/C26H23FN4O2/c1-2-24(32)31-12-10-17(11-13-31)23-14-19-16-28-30-26(19)25(29-23)18-6-8-21(9-7-18)33-22-5-3-4-20(27)15-22/h2-9,14-17H,1,10-13H2,(H,28,30)
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Beijing Innocare Pharma Tech Co., Ltd.

US Patent


Assay Description
In vitro activity of BTK is measured by detecting ADP produced in a kinase reaction with an ADP-Glo™ kinase assay kit from Promega Company. In the ki...


US Patent US10336755 (2019)


BindingDB Entry DOI: 10.7270/Q20G3NH5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM406694
PNG
(US10336755, Example 22a)
Show SMILES C=CC(=O)N1CC[C@@H](C1)c1cc2cn[nH]c2c(n1)-c1ccc(Oc2ccccc2)cc1
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Beijing Innocare Pharma Tech Co., Ltd.

US Patent


Assay Description
In vitro activity of BTK is measured by detecting ADP produced in a kinase reaction with an ADP-Glo™ kinase assay kit from Promega Company. In the ki...


US Patent US10336755 (2019)


BindingDB Entry DOI: 10.7270/Q20G3NH5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM406692
PNG
(1-(3-(7-(4-phenoxyphenyl)-1H-indazol-5-yl)piperidi...)
Show SMILES C=CC(=O)N1CCCC(C1)c1cc(-c2ccc(Oc3ccccc3)cc2)c2[nH]ncc2c1
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Beijing Innocare Pharma Tech Co., Ltd.

US Patent


Assay Description
In vitro activity of BTK is measured by detecting ADP produced in a kinase reaction with an ADP-Glo™ kinase assay kit from Promega Company. In the ki...


US Patent US10336755 (2019)


BindingDB Entry DOI: 10.7270/Q20G3NH5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM406693
PNG
(1-(2-(7-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridi...)
Show SMILES C=CC(=O)N1CCCC1c1cc2cn[nH]c2c(n1)-c1ccc(Oc2ccccc2)cc1
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Beijing Innocare Pharma Tech Co., Ltd.

US Patent


Assay Description
In vitro activity of BTK is measured by detecting ADP produced in a kinase reaction with an ADP-Glo™ kinase assay kit from Promega Company. In the ki...


US Patent US10336755 (2019)


BindingDB Entry DOI: 10.7270/Q20G3NH5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM406675
PNG
(1-(4-(7-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridi...)
Show SMILES C=CC(=O)N1CCC(CC1)c1cc2cn[nH]c2c(n1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H24N4O2/c1-2-24(31)30-14-12-18(13-15-30)23-16-20-17-27-29-26(20)25(28-23)19-8-10-22(11-9-19)32-21-6-4-3-5-7-21/h2-11,16-18H,1,12-15H2,(H,27,29)
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Beijing Innocare Pharma Tech Co., Ltd.

US Patent


Assay Description
In vitro activity of BTK is measured by detecting ADP produced in a kinase reaction with an ADP-Glo™ kinase assay kit from Promega Company. In the ki...


US Patent US10336755 (2019)


BindingDB Entry DOI: 10.7270/Q20G3NH5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM406683
PNG
(1-(3-((7-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyrid...)
Show SMILES C=CC(=O)N1CCC(C1)Nc1cc2cn[nH]c2c(n1)-c1ccc(Oc2ccccc2)cc1
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Beijing Innocare Pharma Tech Co., Ltd.

US Patent


Assay Description
In vitro activity of BTK is measured by detecting ADP produced in a kinase reaction with an ADP-Glo™ kinase assay kit from Promega Company. In the ki...


US Patent US10336755 (2019)


BindingDB Entry DOI: 10.7270/Q20G3NH5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM406691
PNG
(4-(5-(1-(but-2-ynoyl)pyrrolidin-3-yl)-1H-pyrazolo[...)
Show SMILES CC#CC(=O)N1CCC(C1)c1cc2cn[nH]c2c(n1)-c1ccc(cc1)C(=O)Nc1ccccn1
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Beijing Innocare Pharma Tech Co., Ltd.

US Patent


Assay Description
In vitro activity of BTK is measured by detecting ADP produced in a kinase reaction with an ADP-Glo™ kinase assay kit from Promega Company. In the ki...


US Patent US10336755 (2019)


BindingDB Entry DOI: 10.7270/Q20G3NH5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM406670
PNG
(1-(3-(7-(4-(oxetan-3-oxy)phenyl)-1H-pyrazolo[3,4-c...)
Show SMILES C=CC(=O)N1CCCC(C1)c1cc2cn[nH]c2c(n1)-c1ccc(OC2COC2)cc1
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Beijing Innocare Pharma Tech Co., Ltd.

US Patent


Assay Description
In vitro activity of BTK is measured by detecting ADP produced in a kinase reaction with an ADP-Glo™ kinase assay kit from Promega Company. In the ki...


US Patent US10336755 (2019)


BindingDB Entry DOI: 10.7270/Q20G3NH5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM406689
PNG
(1-(3-(7-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridi...)
Show SMILES CC#CC(=O)N1CCCC(C1)c1cc2cn[nH]c2c(n1)-c1ccc(Oc2ccccc2)cc1
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Beijing Innocare Pharma Tech Co., Ltd.

US Patent


Assay Description
In vitro activity of BTK is measured by detecting ADP produced in a kinase reaction with an ADP-Glo™ kinase assay kit from Promega Company. In the ki...


US Patent US10336755 (2019)


BindingDB Entry DOI: 10.7270/Q20G3NH5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM406669
PNG
(1-(3-(7-(4-(morpholinomethyl)phenyl)-1H-pyrazolo[3...)
Show SMILES C=CC(=O)N1CCCC(C1)c1cc2cn[nH]c2c(n1)-c1ccc(CN2CCOCC2)cc1
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Beijing Innocare Pharma Tech Co., Ltd.

US Patent


Assay Description
In vitro activity of BTK is measured by detecting ADP produced in a kinase reaction with an ADP-Glo™ kinase assay kit from Promega Company. In the ki...


US Patent US10336755 (2019)


BindingDB Entry DOI: 10.7270/Q20G3NH5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM406688
PNG
(1-(4-(7-(4-(pyrrolidin-1-ylmethyl)phenyl)-1H-pyraz...)
Show SMILES C=CC(=O)N1CCC(CC1)c1cc2cn[nH]c2c(n1)-c1ccc(CN2CCCC2)cc1
Show InChI InChI=1S/C25H29N5O/c1-2-23(31)30-13-9-19(10-14-30)22-15-21-16-26-28-25(21)24(27-22)20-7-5-18(6-8-20)17-29-11-3-4-12-29/h2,5-8,15-16,19H,1,3-4,9-14,17H2,(H,26,28)
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US Patent
n/an/a>500n/an/an/an/an/an/a



Beijing Innocare Pharma Tech Co., Ltd.

US Patent


Assay Description
In vitro activity of BTK is measured by detecting ADP produced in a kinase reaction with an ADP-Glo™ kinase assay kit from Promega Company. In the ki...


US Patent US10336755 (2019)


BindingDB Entry DOI: 10.7270/Q20G3NH5
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%