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Patent code US10336761

Compile Data Set for Download or QSAR

Found 682 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
TGF-beta receptor type II


(Homo sapiens (Human))
BDBM406800
PNG
(4-{[2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4...)
Show SMILES NC(=O)c1cnccc1Nc1nc(nn2cccc12)-c1ccccn1
Show InChI InChI=1S/C17H13N7O/c18-15(25)11-10-19-8-6-12(11)21-17-14-5-3-9-24(14)23-16(22-17)13-4-1-2-7-20-13/h1-10H,(H2,18,25)(H,19,21,22,23)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406730
PNG
(N-[4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2...)
Show SMILES CC(=O)Nc1cc(Nc2nc(nn3cccc23)-c2cccc(n2)C(F)F)ccn1
Show InChI InChI=1S/C19H15F2N7O/c1-11(29)23-16-10-12(7-8-22-16)24-19-15-6-3-9-28(15)27-18(26-19)14-5-2-4-13(25-14)17(20)21/h2-10,17H,1H3,(H2,22,23,24,26,27,29)
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n/an/a 0.190n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406730
PNG
(N-[4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2...)
Show SMILES CC(=O)Nc1cc(Nc2nc(nn3cccc23)-c2cccc(n2)C(F)F)ccn1
Show InChI InChI=1S/C19H15F2N7O/c1-11(29)23-16-10-12(7-8-22-16)24-19-15-6-3-9-28(15)27-18(26-19)14-5-2-4-13(25-14)17(20)21/h2-10,17H,1H3,(H2,22,23,24,26,27,29)
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n/an/a 0.190n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406951
PNG
(1-({[2-(5-fluoropyridin-2-yl)-4-[(3-fluoropyridin-...)
Show SMILES CC(C)(O)CNCc1ccn2nc(nc(Nc3ccncc3F)c12)-c1ccc(F)cn1
Show InChI InChI=1S/C21H21F2N7O/c1-21(2,31)12-25-9-13-6-8-30-18(13)20(27-16-5-7-24-11-15(16)23)28-19(29-30)17-4-3-14(22)10-26-17/h3-8,10-11,25,31H,9,12H2,1-2H3,(H,24,27,28,29)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM407012
PNG
((3-{[({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-...)
Show SMILES OCC1(CNCc2ccn3nc(nc(Nc4ccncc4F)c23)-c2ccccn2)COC1
Show InChI InChI=1S/C22H22FN7O2/c23-16-10-24-7-4-17(16)27-21-19-15(9-25-11-22(12-31)13-32-14-22)5-8-30(19)29-20(28-21)18-3-1-2-6-26-18/h1-8,10,25,31H,9,11-14H2,(H,24,27,28,29)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406793
PNG
(N-{5-[(4,4-difluoropiperidin-1-yl)methyl]-2-(6-met...)
Show SMILES Cc1cccc(n1)-c1nc(Nc2ccncc2F)c2c(CN3CCC(F)(F)CC3)ccn2n1
Show InChI InChI=1S/C23H22F3N7/c1-15-3-2-4-19(28-15)21-30-22(29-18-5-9-27-13-17(18)24)20-16(6-10-33(20)31-21)14-32-11-7-23(25,26)8-12-32/h2-6,9-10,13H,7-8,11-12,14H2,1H3,(H,27,29,30,31)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM407009
PNG
(N-(4-{[5-(morpholin-4-ylmethyl)-2-(pyridin-2-yl)py...)
Show SMILES CC(=O)Nc1cc(Nc2nc(nn3ccc(CN4CCOCC4)c23)-c2ccccn2)ccn1
Show InChI InChI=1S/C23H24N8O2/c1-16(32)26-20-14-18(5-8-25-20)27-23-21-17(15-30-10-12-33-13-11-30)6-9-31(21)29-22(28-23)19-4-2-3-7-24-19/h2-9,14H,10-13,15H2,1H3,(H2,25,26,27,28,29,32)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406957
PNG
(3-fluoro-N-(5-{[(1-methylcyclobutyl)amino]methyl}-...)
Show SMILES CC1(CNCc2ccn3nc(nc(Nc4ccncc4F)c23)-c2ccccn2)CCC1
Show InChI InChI=1S/C23H24FN7/c1-23(8-4-9-23)15-26-13-16-7-12-31-20(16)22(28-18-6-11-25-14-17(18)24)29-21(30-31)19-5-2-3-10-27-19/h2-3,5-7,10-12,14,26H,4,8-9,13,15H2,1H3,(H,25,28,29,30)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM407043
PNG
(2-[(3R)-3-hydroxypyrrolidin-1-yl]-N-[4-({2-[6-(tri...)
Show SMILES O[C@@H]1CCN(CC(=O)Nc2cc(Nc3nc(nn4cccc34)-c3cccc(n3)C(F)(F)F)ccn2)C1
Show InChI InChI=1S/C23H21F3N8O2/c24-23(25,26)18-5-1-3-16(29-18)21-31-22(17-4-2-9-34(17)32-21)28-14-6-8-27-19(11-14)30-20(36)13-33-10-7-15(35)12-33/h1-6,8-9,11,15,35H,7,10,12-13H2,(H2,27,28,30,31,32,36)/t15-/m1/s1
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM407051
PNG
(N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[...)
Show SMILES FC(F)(F)c1cccc(n1)-c1nc(Nc2ccnc(NC(=O)C3CC3)c2)c2cccn2n1
Show InChI InChI=1S/C21H16F3N7O/c22-21(23,24)16-5-1-3-14(27-16)18-29-19(15-4-2-10-31(15)30-18)26-13-8-9-25-17(11-13)28-20(32)12-6-7-12/h1-5,8-12H,6-7H2,(H2,25,26,28,29,30,32)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406787
PNG
(3-chloro-N-[2-(6-fluoropyridin-2-yl)pyrrolo[2,1-f]...)
Show SMILES Fc1cccc(n1)-c1nc(Nc2ccncc2Cl)c2cccn2n1
Show InChI InChI=1S/C16H10ClFN6/c17-10-9-19-7-6-11(10)21-16-13-4-2-8-24(13)23-15(22-16)12-3-1-5-14(18)20-12/h1-9H,(H,19,21,22,23)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM407010
PNG
(N-(5-{[(2H-1,3-benzodioxol-5-ylmethyl)amino]methyl...)
Show SMILES Fc1cnccc1Nc1nc(nn2ccc(CNCc3ccc4OCOc4c3)c12)-c1ccccn1
Show InChI InChI=1S/C25H20FN7O2/c26-18-14-27-9-6-19(18)30-25-23-17(13-28-12-16-4-5-21-22(11-16)35-15-34-21)7-10-33(23)32-24(31-25)20-3-1-2-8-29-20/h1-11,14,28H,12-13,15H2,(H,27,30,31,32)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406741
PNG
(N-[4-({5-[(4,4-difluoropiperidin-1-yl)methyl]-2-(p...)
Show SMILES CC(=O)Nc1cc(Nc2nc(nn3ccc(CN4CCC(F)(F)CC4)c23)-c2ccccn2)ccn1
Show InChI InChI=1S/C24H24F2N8O/c1-16(35)29-20-14-18(5-10-28-20)30-23-21-17(15-33-12-7-24(25,26)8-13-33)6-11-34(21)32-22(31-23)19-4-2-3-9-27-19/h2-6,9-11,14H,7-8,12-13,15H2,1H3,(H2,28,29,30,31,32,35)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406783
PNG
(N-{2-[6-(difluoromethyl)-5-fluoropyridin-2-yl]pyrr...)
Show SMILES FC(F)c1nc(ccc1F)-c1nc(Nc2ccncc2F)c2cccn2n1
Show InChI InChI=1S/C17H10F4N6/c18-9-3-4-12(23-14(9)15(20)21)16-25-17(13-2-1-7-27(13)26-16)24-11-5-6-22-8-10(11)19/h1-8,15H,(H,22,24,25,26)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406991
PNG
(3-[4-({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-...)
Show SMILES Oc1cccc(c1)N1CCN(Cc2ccn3nc(nc(Nc4ccncc4F)c23)-c2ccccn2)CC1
Show InChI InChI=1S/C27H25FN8O/c28-22-17-29-10-7-23(22)31-27-25-19(8-11-36(25)33-26(32-27)24-6-1-2-9-30-24)18-34-12-14-35(15-13-34)20-4-3-5-21(37)16-20/h1-11,16-17,37H,12-15,18H2,(H,29,31,32,33)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406968
PNG
((3S)-1-({4-[(3-fluoropyridin-4-yl)amino]-2-(6-meth...)
Show SMILES Cc1cccc(n1)-c1nc(Nc2ccncc2F)c2c(CN3CC[C@H](O)C3)ccn2n1
Show InChI InChI=1S/C22H22FN7O/c1-14-3-2-4-19(25-14)21-27-22(26-18-5-8-24-11-17(18)23)20-15(6-10-30(20)28-21)12-29-9-7-16(31)13-29/h2-6,8,10-11,16,31H,7,9,12-13H2,1H3,(H,24,26,27,28)/t16-/m0/s1
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406990
PNG
(4-[({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2-...)
Show SMILES CC(O)CCNCc1ccn2nc(nc(Nc3ccncc3F)c12)-c1ccccn1
Show InChI InChI=1S/C21H22FN7O/c1-14(30)5-9-23-12-15-7-11-29-19(15)21(26-17-6-10-24-13-16(17)22)27-20(28-29)18-4-2-3-8-25-18/h2-4,6-8,10-11,13-14,23,30H,5,9,12H2,1H3,(H,24,26,27,28)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM407017
PNG
(3-fluoro-N-[2-(pyridin-2-yl)-5-({[2-(pyridin-2-yl)...)
Show SMILES CC(C)(NCc1ccn2nc(nc(Nc3ccncc3F)c12)-c1ccccn1)c1ccccn1
Show InChI InChI=1S/C25H23FN8/c1-25(2,21-8-4-6-12-29-21)30-15-17-10-14-34-22(17)24(31-19-9-13-27-16-18(19)26)32-23(33-34)20-7-3-5-11-28-20/h3-14,16,30H,15H2,1-2H3,(H,27,31,32,33)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406959
PNG
(1-({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2-y...)
Show SMILES OC1CCN(Cc2ccn3nc(nc(Nc4ccncc4F)c23)-c2ccccn2)CC1
Show InChI InChI=1S/C22H22FN7O/c23-17-13-24-9-4-18(17)26-22-20-15(14-29-10-6-16(31)7-11-29)5-12-30(20)28-21(27-22)19-3-1-2-8-25-19/h1-5,8-9,12-13,16,31H,6-7,10-11,14H2,(H,24,26,27,28)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406967
PNG
((3S)-1-({2-[6-(difluoromethyl)pyridin-2-yl]-4-[(3-...)
Show SMILES O[C@H]1CCN(Cc2ccn3nc(nc(Nc4ccncc4F)c23)-c2cccc(n2)C(F)F)C1
Show InChI InChI=1S/C22H20F3N7O/c23-15-10-26-7-4-16(15)28-22-19-13(11-31-8-6-14(33)12-31)5-9-32(19)30-21(29-22)18-3-1-2-17(27-18)20(24)25/h1-5,7,9-10,14,20,33H,6,8,11-12H2,(H,26,28,29,30)/t14-/m0/s1
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n/an/a 0.590n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406721
PNG
(3-chloro-N-[2-(5-fluoropyridin-2-yl)pyrrolo[2,1-f]...)
Show SMILES Fc1ccc(nc1)-c1nc(Nc2ccncc2Cl)c2cccn2n1
Show InChI InChI=1S/C16H10ClFN6/c17-11-9-19-6-5-12(11)21-16-14-2-1-7-24(14)23-15(22-16)13-4-3-10(18)8-20-13/h1-9H,(H,19,21,22,23)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM407046
PNG
(2-[(2-hydroxy-2-methylpropyl)amino]-N-[4-({2-[6-(t...)
Show SMILES CC(C)(O)CNCC(=O)Nc1cc(Nc2nc(nn3cccc23)-c2cccc(n2)C(F)(F)F)ccn1
Show InChI InChI=1S/C23H23F3N8O2/c1-22(2,36)13-27-12-19(35)31-18-11-14(8-9-28-18)29-21-16-6-4-10-34(16)33-20(32-21)15-5-3-7-17(30-15)23(24,25)26/h3-11,27,36H,12-13H2,1-2H3,(H2,28,29,31,32,33,35)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406956
PNG
(1-{2-[({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin...)
Show SMILES OC1(CCNCc2ccn3nc(nc(Nc4ccncc4F)c23)-c2ccccn2)CCCC1
Show InChI InChI=1S/C24H26FN7O/c25-18-16-26-12-6-19(18)29-23-21-17(15-27-13-10-24(33)8-2-3-9-24)7-14-32(21)31-22(30-23)20-5-1-4-11-28-20/h1,4-7,11-12,14,16,27,33H,2-3,8-10,13,15H2,(H,26,29,30,31)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406734
PNG
(N-(3-fluoropyridin-4-yl)-2-(4-(trifluoromethyl)thi...)
Show SMILES Fc1cnccc1Nc1nc(nn2cccc12)-c1nc(cs1)C(F)(F)F
Show InChI InChI=1S/C15H8F4N6S/c16-8-6-20-4-3-9(8)21-12-10-2-1-5-25(10)24-13(23-12)14-22-11(7-26-14)15(17,18)19/h1-7H,(H,20,21,23,24)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406958
PNG
(3-fluoro-N-(5-{[(4-methyloxan-4-yl)amino]methyl}-2...)
Show SMILES CC1(CCOCC1)NCc1ccn2nc(nc(Nc3ccncc3F)c12)-c1ccccn1
Show InChI InChI=1S/C23H24FN7O/c1-23(7-12-32-13-8-23)27-14-16-6-11-31-20(16)22(28-18-5-10-25-15-17(18)24)29-21(30-31)19-4-2-3-9-26-19/h2-6,9-11,15,27H,7-8,12-14H2,1H3,(H,25,28,29,30)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406800
PNG
(4-{[2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4...)
Show SMILES NC(=O)c1cnccc1Nc1nc(nn2cccc12)-c1ccccn1
Show InChI InChI=1S/C17H13N7O/c18-15(25)11-10-19-8-6-12(11)21-17-14-5-3-9-24(14)23-16(22-17)13-4-1-2-7-20-13/h1-10H,(H2,18,25)(H,19,21,22,23)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406977
PNG
(3-fluoro-N-[2-(3-fluoro-6-methylpyridin-2-yl)pyrro...)
Show SMILES Cc1ccc(F)c(n1)-c1nc(Nc2ccncc2F)c2cccn2n1
Show InChI InChI=1S/C17H12F2N6/c1-10-4-5-11(18)15(21-10)17-23-16(14-3-2-8-25(14)24-17)22-13-6-7-20-9-12(13)19/h2-9H,1H3,(H,20,22,23,24)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406782
PNG
(3-fluoro-N-[2-(5-fluoropyridin-2-yl)pyrrolo[2,1-f]...)
Show SMILES Fc1ccc(nc1)-c1nc(Nc2ccncc2F)c2cccn2n1
Show InChI InChI=1S/C16H10F2N6/c17-10-3-4-13(20-8-10)15-22-16(14-2-1-7-24(14)23-15)21-12-5-6-19-9-11(12)18/h1-9H,(H,19,21,22,23)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM407054
PNG
(3-cyano-N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]...)
Show SMILES FC(F)(F)c1cccc(n1)-c1nc(Nc2ccnc(NC(=O)CCC#N)c2)c2cccn2n1
Show InChI InChI=1S/C21H15F3N8O/c22-21(23,24)16-6-1-4-14(28-16)19-30-20(15-5-3-11-32(15)31-19)27-13-8-10-26-17(12-13)29-18(33)7-2-9-25/h1,3-6,8,10-12H,2,7H2,(H2,26,27,29,30,31,33)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406731
PNG
(3-fluoro-N-[2-(6-fluoropyridin-2-yl)pyrrolo[2,1-f]...)
Show SMILES Fc1cccc(n1)-c1nc(Nc2ccncc2F)c2cccn2n1
Show InChI InChI=1S/C16H10F2N6/c17-10-9-19-7-6-11(10)21-16-13-4-2-8-24(13)23-15(22-16)12-3-1-5-14(18)20-12/h1-9H,(H,19,21,22,23)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406729
PNG
(3-fluoro-N-[2-(4-methyl-1,3-thiazol-2-yl)pyrrolo[2...)
Show SMILES Cc1csc(n1)-c1nc(Nc2ccncc2F)c2cccn2n1
Show InChI InChI=1S/C15H11FN6S/c1-9-8-23-15(18-9)14-20-13(12-3-2-6-22(12)21-14)19-11-4-5-17-7-10(11)16/h2-8H,1H3,(H,17,19,20,21)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406699
PNG
(3-chloro-N-[2-(5-fluoro-6-methylpyridin-2-yl)pyrro...)
Show SMILES Cc1nc(ccc1F)-c1nc(Nc2ccncc2Cl)c2cccn2n1
Show InChI InChI=1S/C17H12ClFN6/c1-10-12(19)4-5-14(21-10)16-23-17(15-3-2-8-25(15)24-16)22-13-6-7-20-9-11(13)18/h2-9H,1H3,(H,20,22,23,24)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM407003
PNG
((2S)-3-[({4-[(3-fluoropyridin-4-yl)amino]-2-(pyrid...)
Show SMILES OC[C@@H](O)CNCc1ccn2nc(nc(Nc3ccncc3F)c12)-c1ccccn1
Show InChI InChI=1S/C20H20FN7O2/c21-15-11-22-7-4-16(15)25-20-18-13(9-23-10-14(30)12-29)5-8-28(18)27-19(26-20)17-3-1-2-6-24-17/h1-8,11,14,23,29-30H,9-10,12H2,(H,22,25,26,27)/t14-/m0/s1
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406736
PNG
(N-(4-{[2-(5-fluoro-6-methylpyridin-2-yl)pyrrolo[2,...)
Show SMILES CC(=O)Nc1cc(Nc2nc(nn3cccc23)-c2ccc(F)c(C)n2)ccn1
Show InChI InChI=1S/C19H16FN7O/c1-11-14(20)5-6-15(22-11)18-25-19(16-4-3-9-27(16)26-18)24-13-7-8-21-17(10-13)23-12(2)28/h3-10H,1-2H3,(H2,21,23,24,25,26,28)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406834
PNG
(N-{4-[(5-{[(2-hydroxy-2-methylpropyl)amino]methyl}...)
Show SMILES CC(=O)Nc1cc(Nc2nc(nn3ccc(CNCC(C)(C)O)c23)-c2ccccn2)ccn1
Show InChI InChI=1S/C23H26N8O2/c1-15(32)27-19-12-17(7-10-26-19)28-22-20-16(13-24-14-23(2,3)33)8-11-31(20)30-21(29-22)18-6-4-5-9-25-18/h4-12,24,33H,13-14H2,1-3H3,(H2,26,27,28,29,30,32)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406949
PNG
((3R)-1-({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridi...)
Show SMILES O[C@@H]1CCN(Cc2ccn3nc(nc(Nc4ccncc4F)c23)-c2ccccn2)C1
Show InChI InChI=1S/C21H20FN7O/c22-16-11-23-8-4-17(16)25-21-19-14(12-28-9-6-15(30)13-28)5-10-29(19)27-20(26-21)18-3-1-2-7-24-18/h1-5,7-8,10-11,15,30H,6,9,12-13H2,(H,23,25,26,27)/t15-/m1/s1
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM407036
PNG
(2-(4-acetylpiperazin-1-yl)-N-[4-({2-[6-(trifluorom...)
Show SMILES CC(=O)N1CCN(CC(=O)Nc2cc(Nc3nc(nn4cccc34)-c3cccc(n3)C(F)(F)F)ccn2)CC1
Show InChI InChI=1S/C25H24F3N9O2/c1-16(38)36-12-10-35(11-13-36)15-22(39)32-21-14-17(7-8-29-21)30-24-19-5-3-9-37(19)34-23(33-24)18-4-2-6-20(31-18)25(26,27)28/h2-9,14H,10-13,15H2,1H3,(H2,29,30,32,33,34,39)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM407007
PNG
(N-(4-{[2-(6-fluoropyridin-2-yl)pyrrolo[2,1-f][1,2,...)
Show SMILES CC(=O)Nc1cc(Nc2nc(nn3cccc23)-c2cccc(F)n2)ccn1
Show InChI InChI=1S/C18H14FN7O/c1-11(27)21-16-10-12(7-8-20-16)22-18-14-5-3-9-26(14)25-17(24-18)13-4-2-6-15(19)23-13/h2-10H,1H3,(H2,20,21,22,24,25,27)
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n/an/a 0.860n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM407028
PNG
(Methyl N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]p...)
Show SMILES COC(=O)Nc1cc(Nc2nc(nn3cccc23)-c2cccc(n2)C(F)(F)F)ccn1
Show InChI InChI=1S/C19H14F3N7O2/c1-31-18(30)26-15-10-11(7-8-23-15)24-17-13-5-3-9-29(13)28-16(27-17)12-4-2-6-14(25-12)19(20,21)22/h2-10H,1H3,(H2,23,24,26,27,28,30)
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n/an/a 0.870n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM407029
PNG
(N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[...)
Show SMILES CCC(=O)Nc1cc(Nc2nc(nn3cccc23)-c2cccc(n2)C(F)(F)F)ccn1
Show InChI InChI=1S/C20H16F3N7O/c1-2-17(31)27-16-11-12(8-9-24-16)25-19-14-6-4-10-30(14)29-18(28-19)13-5-3-7-15(26-13)20(21,22)23/h3-11H,2H2,1H3,(H2,24,25,27,28,29,31)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406750
PNG
(N-[4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2...)
Show SMILES FC(F)c1cccc(n1)-c1nc(Nc2ccnc(NC(=O)CN3CCCC3)c2)c2cccn2n1
Show InChI InChI=1S/C23H22F2N8O/c24-21(25)16-5-3-6-17(28-16)22-30-23(18-7-4-12-33(18)31-22)27-15-8-9-26-19(13-15)29-20(34)14-32-10-1-2-11-32/h3-9,12-13,21H,1-2,10-11,14H2,(H2,26,27,29,30,31,34)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406795
PNG
(N-{2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f...)
Show SMILES FC(F)c1cccc(n1)-c1nc(Nc2ccncc2F)c2cccn2n1
Show InChI InChI=1S/C17H11F3N6/c18-10-9-21-7-6-11(10)23-17-14-5-2-8-26(14)25-16(24-17)13-4-1-3-12(22-13)15(19)20/h1-9,15H,(H,21,23,24,25)
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n/an/a 0.920n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406804
PNG
(3-chloro-N-[2-(4-methyl-1,3-thiazol-2-yl)pyrrolo[2...)
Show SMILES Cc1csc(n1)-c1nc(Nc2ccncc2Cl)c2cccn2n1
Show InChI InChI=1S/C15H11ClN6S/c1-9-8-23-15(18-9)14-20-13(12-3-2-6-22(12)21-14)19-11-4-5-17-7-10(11)16/h2-8H,1H3,(H,17,19,20,21)
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n/an/a 0.920n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406975
PNG
(2-[4-({4-[(3-fluoropyridin-4-yl)amino]-2-(6-methyl...)
Show SMILES Cc1cccc(n1)-c1nc(Nc2ccncc2F)c2c(CN3CCN(CCO)CC3)ccn2n1
Show InChI InChI=1S/C24H27FN8O/c1-17-3-2-4-21(27-17)23-29-24(28-20-5-7-26-15-19(20)25)22-18(6-8-33(22)30-23)16-32-11-9-31(10-12-32)13-14-34/h2-8,15,34H,9-14,16H2,1H3,(H,26,28,29,30)
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n/an/a 0.930n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406774
PNG
(3-fluoro-N-[2-(6-methylpyridin-2-yl)pyrrolo[2,1-f]...)
Show SMILES Cc1cccc(n1)-c1nc(Nc2ccncc2F)c2cccn2n1
Show InChI InChI=1S/C17H13FN6/c1-11-4-2-5-14(20-11)16-22-17(15-6-3-9-24(15)23-16)21-13-7-8-19-10-12(13)18/h2-10H,1H3,(H,19,21,22,23)
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n/an/a 0.930n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406948
PNG
((3S)-1-({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridi...)
Show SMILES O[C@H]1CCN(Cc2ccn3nc(nc(Nc4ccncc4F)c23)-c2ccccn2)C1
Show InChI InChI=1S/C21H20FN7O/c22-16-11-23-8-4-17(16)25-21-19-14(12-28-9-6-15(30)13-28)5-10-29(19)27-20(26-21)18-3-1-2-7-24-18/h1-5,7-8,10-11,15,30H,6,9,12-13H2,(H,23,25,26,27)/t15-/m0/s1
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n/an/a 0.930n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406961
PNG
(4-N-({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2...)
Show SMILES CN(C)C1CCC(CC1)NCc1ccn2nc(nc(Nc3ccncc3F)c12)-c1ccccn1
Show InChI InChI=1S/C25H29FN8/c1-33(2)19-8-6-18(7-9-19)29-15-17-11-14-34-23(17)25(30-21-10-13-27-16-20(21)26)31-24(32-34)22-5-3-4-12-28-22/h3-5,10-14,16,18-19,29H,6-9,15H2,1-2H3,(H,27,30,31,32)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM407032
PNG
(2-(4-methylpiperazin-1-yl)-N-[4-({2-[6-(trifluorom...)
Show SMILES CN1CCN(CC(=O)Nc2cc(Nc3nc(nn4cccc34)-c3cccc(n3)C(F)(F)F)ccn2)CC1
Show InChI InChI=1S/C24H24F3N9O/c1-34-10-12-35(13-11-34)15-21(37)31-20-14-16(7-8-28-20)29-23-18-5-3-9-36(18)33-22(32-23)17-4-2-6-19(30-17)24(25,26)27/h2-9,14H,10-13,15H2,1H3,(H2,28,29,31,32,33,37)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406963
PNG
(3-fluoro-N-(5-{[(oxolan-2-ylmethyl)amino]methyl}-2...)
Show SMILES Fc1cnccc1Nc1nc(nn2ccc(CNCC3CCCO3)c12)-c1ccccn1
Show InChI InChI=1S/C22H22FN7O/c23-17-14-24-9-6-18(17)27-22-20-15(12-25-13-16-4-3-11-31-16)7-10-30(20)29-21(28-22)19-5-1-2-8-26-19/h1-2,5-10,14,16,25H,3-4,11-13H2,(H,24,27,28,29)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM406740
PNG
(N-{2-[6-(difluoromethyl)pyridin-2-yl]-5-[(4,4-difl...)
Show SMILES FC(F)c1cccc(n1)-c1nc(Nc2ccncc2F)c2c(CN3CCC(F)(F)CC3)ccn2n1
Show InChI InChI=1S/C23H20F5N7/c24-15-12-29-8-4-16(15)31-22-19-14(13-34-10-6-23(27,28)7-11-34)5-9-35(19)33-21(32-22)18-3-1-2-17(30-18)20(25)26/h1-5,8-9,12,20H,6-7,10-11,13H2,(H,29,31,32,33)
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Bristol-Myers Squibb Co.

US Patent


Assay Description
Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...


US Patent US10336761 (2019)


BindingDB Entry DOI: 10.7270/Q2M90C2R
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%