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Patent code US10343992

Compile Data Set for Download or QSAR

Found 273 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404427
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-4- (1,3-dimethyl-1H...)
Show SMILES Cc1nn(C)cc1-c1ccc(cc1F)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C17H18FN5O/c1-11-15(9-22(2)21-11)14-4-3-12(7-16(14)18)17(24)20-13-5-6-23(8-13)10-19/h3-4,7,9,13H,5-6,8H2,1-2H3,(H,20,24)/t13-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404428
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-4- (1,3-dimethyl-1H...)
Show SMILES Cc1nn(C)cc1-c1ccc(C(=O)N[C@@H]2CCN(C2)C#N)c(F)c1
Show InChI InChI=1S/C17H18FN5O/c1-11-15(9-22(2)21-11)12-3-4-14(16(18)7-12)17(24)20-13-5-6-23(8-13)10-19/h3-4,7,9,13H,5-6,8H2,1-2H3,(H,20,24)/t13-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404429
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-4- (1-ethyl-1H-pyra...)
Show SMILES CCn1cc(cn1)-c1ccc(C(=O)N[C@@H]2CCN(C2)C#N)c(F)c1
Show InChI InChI=1S/C17H18FN5O/c1-2-23-9-13(8-20-23)12-3-4-15(16(18)7-12)17(24)21-14-5-6-22(10-14)11-19/h3-4,7-9,14H,2,5-6,10H2,1H3,(H,21,24)/t14-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404445
PNG
((R)-N-(1-cyanopyrrolidin- 3-yl)-5-(2-methoxyphenyl...)
Show SMILES COc1ccccc1-c1cc(n[nH]1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C16H17N5O2/c1-23-15-5-3-2-4-12(15)13-8-14(20-19-13)16(22)18-11-6-7-21(9-11)10-17/h2-5,8,11H,6-7,9H2,1H3,(H,18,22)(H,19,20)/t11-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404448
PNG
((R)-N-(1-cyanopyrrolidin- 3-yl)-3-(4- methoxypheny...)
Show SMILES COc1ccc(cc1)-c1cc(on1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C16H16N4O3/c1-22-13-4-2-11(3-5-13)14-8-15(23-19-14)16(21)18-12-6-7-20(9-12)10-17/h2-5,8,12H,6-7,9H2,1H3,(H,18,21)/t12-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404450
PNG
((R)-N-(1-cyanopyrrolidin- 3-yl)-phenyl-1H-pyrazole...)
Show SMILES O=C(N[C@@H]1CCN(C1)C#N)c1ccn(n1)-c1ccccc1
Show InChI InChI=1S/C15H15N5O/c16-11-19-8-6-12(10-19)17-15(21)14-7-9-20(18-14)13-4-2-1-3-5-13/h1-5,7,9,12H,6,8,10H2,(H,17,21)/t12-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404453
PNG
((R)-N-(1-cyanopyrrolidin- 3-yl)-2-fluoro-4-(2- met...)
Show SMILES Cc1nccc(n1)-c1ccc(C(=O)N[C@@H]2CCN(C2)C#N)c(F)c1
Show InChI InChI=1S/C17H16FN5O/c1-11-20-6-4-16(21-11)12-2-3-14(15(18)8-12)17(24)22-13-5-7-23(9-13)10-19/h2-4,6,8,13H,5,7,9H2,1H3,(H,22,24)/t13-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404471
PNG
((R)-3-chloro-N-(1- cyanopyrrolidin-3-yl)-5-(4- flu...)
Show SMILES Fc1ccc(cc1)-c1cnc(C(=O)N[C@@H]2CCN(C2)C#N)c(Cl)c1
Show InChI InChI=1S/C17H14ClFN4O/c18-15-7-12(11-1-3-13(19)4-2-11)8-21-16(15)17(24)22-14-5-6-23(9-14)10-20/h1-4,7-8,14H,5-6,9H2,(H,22,24)/t14-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404497
PNG
((R)-N-(1-cyanopyrrolidin- 3-yl)-2-fluoro-4-((4- me...)
Show SMILES COc1ccnc(Nc2ccc(C(=O)N[C@@H]3CCN(C3)C#N)c(F)c2)n1
Show InChI InChI=1S/C17H17FN6O2/c1-26-15-4-6-20-17(23-15)22-11-2-3-13(14(18)8-11)16(25)21-12-5-7-24(9-12)10-19/h2-4,6,8,12H,5,7,9H2,1H3,(H,21,25)(H,20,22,23)/t12-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404520
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-2-fluoro-4-(pyrazol...)
Show SMILES Fc1cc(ccc1C(=O)N[C@@H]1CCN(C1)C#N)-c1ccn2nccc2n1
Show InChI InChI=1S/C18H15FN6O/c19-15-9-12(16-5-8-25-17(23-16)3-6-21-25)1-2-14(15)18(26)22-13-4-7-24(10-13)11-20/h1-3,5-6,8-9,13H,4,7,10H2,(H,22,26)/t13-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404530
PNG
((R)-N-(1- cyanopyrrolidin- 3-yl)-2-fluoro-4- (5-fl...)
Show SMILES Cc1ncc(F)c(n1)-c1ccc(C(=O)N[C@@H]2CCN(C2)C#N)c(F)c1
Show InChI InChI=1S/C17H15F2N5O/c1-10-21-7-15(19)16(22-10)11-2-3-13(14(18)6-11)17(25)23-12-4-5-24(8-12)9-20/h2-3,6-7,12H,4-5,8H2,1H3,(H,23,25)/t12-/m1/s1
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Missions Therapeutics Limited

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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404560
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-4-(4-cyclopropylpyr...)
Show SMILES O=C(N[C@@H]1CCN(C1)C#N)c1ccc2N(CCOc2c1)c1nccc(n1)C1CC1
Show InChI InChI=1S/C21H22N6O2/c22-13-26-8-6-16(12-26)24-20(28)15-3-4-18-19(11-15)29-10-9-27(18)21-23-7-5-17(25-21)14-1-2-14/h3-5,7,11,14,16H,1-2,6,8-10,12H2,(H,24,28)/t16-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404577
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-1-methyl-6-(1-methy...)
Show SMILES Cn1c(cc2ccc(Br)cc12)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C15H15BrN4O/c1-19-13-7-11(16)3-2-10(13)6-14(19)15(21)18-12-4-5-20(8-12)9-17/h2-3,6-7,12H,4-5,8H2,1H3,(H,18,21)/t12-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404580
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-3-fluoro-1-methyl-5...)
Show SMILES Cn1cc(cn1)-c1ccc2n(C)c(C(=O)N[C@@H]3CCN(C3)C#N)c(F)c2c1
Show InChI InChI=1S/C19H19FN6O/c1-24-9-13(8-22-24)12-3-4-16-15(7-12)17(20)18(25(16)2)19(27)23-14-5-6-26(10-14)11-21/h3-4,7-9,14H,5-6,10H2,1-2H3,(H,23,27)/t14-/m1/s1
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Missions Therapeutics Limited

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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404344
PNG
(US10343992, Example 3)
Show SMILES Clc1ccccc1-c1ccc(cc1)C(=O)NC1CCN(C1)C#N
Show InChI InChI=1S/C18H16ClN3O/c19-17-4-2-1-3-16(17)13-5-7-14(8-6-13)18(23)21-15-9-10-22(11-15)12-20/h1-8,15H,9-11H2,(H,21,23)
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404383
PNG
((R)-6-(4-chlorophenyl)-N-(1- cyanopyrrolidin-3-yl)...)
Show SMILES Clc1ccc(cc1)-c1ccc(cn1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C17H15ClN4O/c18-14-4-1-12(2-5-14)16-6-3-13(9-20-16)17(23)21-15-7-8-22(10-15)11-19/h1-6,9,15H,7-8,10H2,(H,21,23)/t15-/m1/s1
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Missions Therapeutics Limited

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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404443
PNG
((R)-N-(1-cyanopyrrolidin- 3-yl)-5-(4-methoxyphenyl...)
Show SMILES COc1ccc(cc1)C1C=C(NC(=O)c2ccc(cc2F)-c2cnn(C)c2)N=N1
Show InChI InChI=1S/C21H18FN5O2/c1-27-12-15(11-23-27)14-5-8-17(18(22)9-14)21(28)24-20-10-19(25-26-20)13-3-6-16(29-2)7-4-13/h3-12,19H,1-2H3,(H,24,28)
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404464
PNG
((R)-6-(3-cyanophenyl)- N-(1-cyanopyrrolidin-3- yl)...)
Show SMILES O=C(N[C@@H]1CCN(C1)C#N)c1cnn2cc(ccc12)-c1cccc(c1)C#N
Show InChI InChI=1S/C20H16N6O/c21-9-14-2-1-3-15(8-14)16-4-5-19-18(10-23-26(19)11-16)20(27)24-17-6-7-25(12-17)13-22/h1-5,8,10-11,17H,6-7,12H2,(H,24,27)/t17-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404474
PNG
((R)-N-(1-cyanopyrrolidin- 3-yl)-5-(1-methyl-1H- py...)
Show SMILES Cn1cc(cn1)-c1ccc2[nH]nc(C(=O)N[C@@H]3CCN(C3)C#N)c2c1
Show InChI InChI=1S/C17H17N7O/c1-23-8-12(7-19-23)11-2-3-15-14(6-11)16(22-21-15)17(25)20-13-4-5-24(9-13)10-18/h2-3,6-8,13H,4-5,9H2,1H3,(H,20,25)(H,21,22)/t13-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404476
PNG
((R)-N-(1- cyanopyrrolidin- 3-yl)-6-(3,5- dimethyli...)
Show SMILES Cc1noc(C)c1-c1ccc2cc([nH]c2c1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C19H19N5O2/c1-11-18(12(2)26-23-11)14-4-3-13-7-17(22-16(13)8-14)19(25)21-15-5-6-24(9-15)10-20/h3-4,7-8,15,22H,5-6,9H2,1-2H3,(H,21,25)/t15-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404478
PNG
((R)-N-(1-cyanopyrrolidin- 3-yl)-5-(1-methyl-1H- py...)
Show SMILES Cn1cc(cn1)-c1ccc2[nH]c(cc2c1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C18H18N6O/c1-23-9-14(8-20-23)12-2-3-16-13(6-12)7-17(22-16)18(25)21-15-4-5-24(10-15)11-19/h2-3,6-9,15,22H,4-5,10H2,1H3,(H,21,25)/t15-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404515
PNG
((R)-6-(3-cyanophenyl)-N-(1-cyanopyrrolidin-3-yl)-3...)
Show SMILES Fc1c(nc2ccc(cn12)-c1cccc(c1)C#N)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C20H15FN6O/c21-19-18(20(28)24-16-6-7-26(11-16)12-23)25-17-5-4-15(10-27(17)19)14-3-1-2-13(8-14)9-22/h1-5,8,10,16H,6-7,11H2,(H,24,28)/t16-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404532
PNG
((R)-N-(1- cyanopyrrolidin- 3-yl)-2-fluoro-4- (2-me...)
Show SMILES Cc1nc2nccc2c([nH]1)-c1ccc(C(=O)N[C@@H]2CCN(C2)C#N)c(F)c1
Show InChI InChI=1S/C19H17FN6O/c1-11-23-17(15-4-6-22-18(15)24-11)12-2-3-14(16(20)8-12)19(27)25-13-5-7-26(9-13)10-21/h2-4,6,8,13H,5,7,9H2,1H3,(H,25,27)(H,22,23,24)/t13-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404533
PNG
((R)-N-(1- cyanopyrrolidin- 3-yl)-2-fluoro-4- (imid...)
Show SMILES Fc1cc(ccc1C(=O)N[C@@H]1CCN(C1)C#N)-c1cnc2cnccn12
Show InChI InChI=1S/C18H15FN6O/c19-15-7-12(16-8-22-17-9-21-4-6-25(16)17)1-2-14(15)18(26)23-13-3-5-24(10-13)11-20/h1-2,4,6-9,13H,3,5,10H2,(H,23,26)/t13-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404549
PNG
((3aR,6aR)-5-cyano-N-(2- fluoro-5- (trifluoromethyl...)
Show SMILES Fc1cc(ccc1OC(=O)N1CC2CN(C[C@@H]2C1)C#N)C(F)(F)F
Show InChI InChI=1S/C15H13F4N3O2/c16-12-3-11(15(17,18)19)1-2-13(12)24-14(23)22-6-9-4-21(8-20)5-10(9)7-22/h1-3,9-10H,4-7H2/t9-,10?/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404550
PNG
((3aR,6aR)-5-cyano-N-(5- phenyl-pyridin-2- yl)hexah...)
Show SMILES O=C(Oc1ccc(cn1)-c1ccccc1)N1CC2CN(C[C@@H]2C1)C#N
Show InChI InChI=1S/C19H18N4O2/c20-13-22-9-16-11-23(12-17(16)10-22)19(24)25-18-7-6-15(8-21-18)14-4-2-1-3-5-14/h1-8,16-17H,9-12H2/t16-,17?/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404606
PNG
(1-(1-cyanopyrrolidin-3- yl)-1-methyl-3-(3- phenoxy...)
Show SMILES O=C(NC1CCN(C1)C#N)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C18H18N4O2/c19-13-22-11-10-15(12-22)21-18(23)20-14-6-8-17(9-7-14)24-16-4-2-1-3-5-16/h1-9,15H,10-12H2,(H2,20,21,23)
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404385
PNG
((R)-4-(3-chloropyridin-4-yl)-N- (1-cyanopyrrolidin...)
Show SMILES Clc1cnccc1-c1ccc(cc1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C17H15ClN4O/c18-16-9-20-7-5-15(16)12-1-3-13(4-2-12)17(23)21-14-6-8-22(10-14)11-19/h1-5,7,9,14H,6,8,10H2,(H,21,23)/t14-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404392
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-4- (1-methyl-1H-pyr...)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C16H17N5O/c1-20-9-14(8-18-20)12-2-4-13(5-3-12)16(22)19-15-6-7-21(10-15)11-17/h2-5,8-9,15H,6-7,10H2,1H3,(H,19,22)/t15-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404438
PNG
((3aR,6aR)-5-cyano-N-(2-fluoro-4-(trifluoromethyl)p...)
Show SMILES Fc1cc(ccc1NC(=O)N1CC[C@@H]2CN(C[C@H]12)C#N)C(F)(F)F
Show InChI InChI=1S/C15H14F4N4O/c16-11-5-10(15(17,18)19)1-2-12(11)21-14(24)23-4-3-9-6-22(8-20)7-13(9)23/h1-2,5,9,13H,3-4,6-7H2,(H,21,24)/t9-,13+/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404439
PNG
(US10343992, Example 91)
Show SMILES Fc1cc(Nc2ncccn2)ccc1C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C16H15FN6O/c17-14-8-11(22-16-19-5-1-6-20-16)2-3-13(14)15(24)21-12-4-7-23(9-12)10-18/h1-3,5-6,8,12H,4,7,9H2,(H,21,24)(H,19,20,22)/t12-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404479
PNG
((R)-N-(1-cyanopyrrolidin- 3-yl)-2,3-difluoro-4-(1-...)
Show SMILES Cn1cc(cn1)-c1ccc(-c2ccc3[nH]c(cc3c2)C(=O)N[C@@H]2CCN(C2)C#N)c(F)c1F
Show InChI InChI=1S/C24H20F2N6O/c1-31-11-16(10-28-31)19-4-3-18(22(25)23(19)26)14-2-5-20-15(8-14)9-21(30-20)24(33)29-17-6-7-32(12-17)13-27/h2-5,8-11,17,30H,6-7,12H2,1H3,(H,29,33)/t17-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404502
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-6-(3, 5-dimethyliso...)
Show SMILES CC(C)Cn1nc(C(=O)N[C@@H]2CCN(C2)C#N)c2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C22H26N6O2/c1-13(2)10-28-19-9-16(20-14(3)26-30-15(20)4)5-6-18(19)21(25-28)22(29)24-17-7-8-27(11-17)12-23/h5-6,9,13,17H,7-8,10-11H2,1-4H3,(H,24,29)/t17-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404505
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-N-methyl-5-(1-methy...)
Show SMILES CN([C@@H]1CCN(C1)C#N)C(=O)c1cc2cc(ccc2[nH]1)-c1cnn(C)c1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404539
PNG
((R)-3-(4-chlorophenyl)-N-(1-cyanopyrrolidin-3-yl)a...)
Show SMILES Clc1ccc(cc1)C1CN(C1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C15H17ClN4O/c16-13-3-1-11(2-4-13)12-7-20(8-12)15(21)18-14-5-6-19(9-14)10-17/h1-4,12,14H,5-9H2,(H,18,21)/t14-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404561
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-4-((4-cyclopropylpy...)
Show SMILES Fc1cc(ccc1Nc1nccc(n1)C1CC1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C19H19FN6O/c20-15-9-13(18(27)23-14-6-8-26(10-14)11-21)3-4-17(15)25-19-22-7-5-16(24-19)12-1-2-12/h3-5,7,9,12,14H,1-2,6,8,10H2,(H,23,27)(H,22,24,25)/t14-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404562
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-4-((4-cyclopropylpy...)
Show SMILES Fc1c(Nc2nccc(n2)C2CC2)ccc(C(=O)N[C@@H]2CCN(C2)C#N)c1F
Show InChI InChI=1S/C19H18F2N6O/c20-16-13(18(28)24-12-6-8-27(9-12)10-22)3-4-15(17(16)21)26-19-23-7-5-14(25-19)11-1-2-11/h3-5,7,11-12H,1-2,6,8-9H2,(H,24,28)(H,23,25,26)/t12-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404582
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-3-(1-phenyl-1H-pyra...)
Show SMILES O=C(N[C@@H]1CCN(C1)C#N)N1CC(C1)c1ccn(n1)-c1ccccc1
Show InChI InChI=1S/C18H20N6O/c19-13-22-8-6-15(12-22)20-18(25)23-10-14(11-23)17-7-9-24(21-17)16-4-2-1-3-5-16/h1-5,7,9,14-15H,6,8,10-12H2,(H,20,25)/t15-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404586
PNG
((R)-3-(benzyloxy)-N-(1-cyanopyrrolidin-3-yl)-3-phe...)
Show SMILES O=C(N[C@@H]1CCN(C1)C#N)N1CC(C1)(OCc1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H24N4O2/c23-17-25-12-11-20(13-25)24-21(27)26-15-22(16-26,19-9-5-2-6-10-19)28-14-18-7-3-1-4-8-18/h1-10,20H,11-16H2,(H,24,27)/t20-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404588
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-1-(4-cyclopropylpyr...)
Show SMILES CN([C@@H]1CCN(C1)C#N)C(=O)c1ccc2N(CCc2c1)c1nccc(n1)C1CC1
Show InChI InChI=1S/C22H24N6O/c1-26(18-8-10-27(13-18)14-23)21(29)17-4-5-20-16(12-17)7-11-28(20)22-24-9-6-19(25-22)15-2-3-15/h4-6,9,12,15,18H,2-3,7-8,10-11,13H2,1H3/t18-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404590
PNG
((3aR,6aR)-5- cyano-N-(4-(2- methylpyridin-4- yl)ph...)
Show SMILES Cc1cc(ccn1)-c1ccc(NC(=O)N2CC[C@@H]3CN(C[C@H]23)C#N)cc1
Show InChI InChI=1S/C20H21N5O/c1-14-10-16(6-8-22-14)15-2-4-18(5-3-15)23-20(26)25-9-7-17-11-24(13-21)12-19(17)25/h2-6,8,10,17,19H,7,9,11-12H2,1H3,(H,23,26)/t17-,19+/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404602
PNG
(1-[1,1''-biphenyl]-4-yl)-3-(1- cyanopyrrolidin-3-y...)
Show SMILES O=C(NC1CCN(C1)C#N)Nc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C18H18N4O/c19-13-22-11-10-17(12-22)21-18(23)20-16-8-6-15(7-9-16)14-4-2-1-3-5-14/h1-9,17H,10-12H2,(H2,20,21,23)
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404620
PNG
((R)-N-(1- cyanopyrrolidin- 3-yl)-3-(2,4- difluorop...)
Show SMILES Fc1ccc(-c2cc(on2)C(=O)N[C@@H]2CCN(C2)C#N)c(F)c1
Show InChI InChI=1S/C15H12F2N4O2/c16-9-1-2-11(12(17)5-9)13-6-14(23-20-13)15(22)19-10-3-4-21(7-10)8-18/h1-2,5-6,10H,3-4,7H2,(H,19,22)/t10-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404349
PNG
(3-(3-chlorophenyl)-N-(1- cyanopyrrolidin-3-yl)isox...)
Show SMILES Clc1cccc(c1)-c1cc(on1)C(=O)NC1CCN(C1)C#N
Show InChI InChI=1S/C15H13ClN4O2/c16-11-3-1-2-10(6-11)13-7-14(22-19-13)15(21)18-12-4-5-20(8-12)9-17/h1-3,6-7,12H,4-5,8H2,(H,18,21)
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404354
PNG
(3'-chloro-N-(1-cyanopyrrolidin-3- yl)-[1,1'-biphen...)
Show SMILES Clc1cccc(c1)-c1ccc(cc1)C(=O)NC1CCN(C1)C#N
Show InChI InChI=1S/C18H16ClN3O/c19-16-3-1-2-15(10-16)13-4-6-14(7-5-13)18(23)21-17-8-9-22(11-17)12-20/h1-7,10,17H,8-9,11H2,(H,21,23)
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404384
PNG
((R)-2-(2-chlorophenyl)-N-(1- cyanopyrrolidin-3-yl)...)
Show SMILES Clc1ccccc1-c1ncc(s1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C15H13ClN4OS/c16-12-4-2-1-3-11(12)15-18-7-13(22-15)14(21)19-10-5-6-20(8-10)9-17/h1-4,7,10H,5-6,8H2,(H,19,21)/t10-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404460
PNG
((R)-N-(1-cyanopyrrolidin- 3-yl)-3,5-difluoro-4-(1-...)
Show SMILES Cn1cc(cn1)-c1c(F)cc(cc1F)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C16H15F2N5O/c1-22-7-11(6-20-22)15-13(17)4-10(5-14(15)18)16(24)21-12-2-3-23(8-12)9-19/h4-7,12H,2-3,8H2,1H3,(H,21,24)/t12-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404466
PNG
((R)-N-(1-cyanopyrrolidin- 3-yl)-2-fluoro-4- (imida...)
Show SMILES Fc1cc(ccc1C(=O)N[C@@H]1CCN(C1)C#N)-c1ccc2nccn2c1
Show InChI InChI=1S/C19H16FN5O/c20-17-9-13(14-2-4-18-22-6-8-25(18)10-14)1-3-16(17)19(26)23-15-5-7-24(11-15)12-21/h1-4,6,8-10,15H,5,7,11H2,(H,23,26)/t15-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404469
PNG
((R)-N-(1-cyanopyrrolidin- 3-yl)-3-fluoro-5-(1-meth...)
Show SMILES Cn1ccc2cc(cnc12)-c1cnc(C(=O)N[C@@H]2CCN(C2)C#N)c(F)c1
Show InChI InChI=1S/C19H17FN6O/c1-25-4-2-12-6-13(9-23-18(12)25)14-7-16(20)17(22-8-14)19(27)24-15-3-5-26(10-15)11-21/h2,4,6-9,15H,3,5,10H2,1H3,(H,24,27)/t15-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404503
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-1-(cyclopropylmethy...)
Show SMILES Cc1noc(C)c1-c1ccc2c(nn(CC3CC3)c2c1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C22H24N6O2/c1-13-20(14(2)30-26-13)16-5-6-18-19(9-16)28(10-15-3-4-15)25-21(18)22(29)24-17-7-8-27(11-17)12-23/h5-6,9,15,17H,3-4,7-8,10-11H2,1-2H3,(H,24,29)/t17-/m1/s1
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Missions Therapeutics Limited

US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US10343992 (2019)


BindingDB Entry DOI: 10.7270/Q2MC92BQ
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%