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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gonadotropin-releasing hormone receptor (Homo sapiens (Human)) | BDBM405268 (1-(4-(7-(2,6-difluorobenzyl)-3-((dimethylamino)met...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.110 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co., Ltd US Patent | Assay Description Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin... | US Patent US10344034 (2019) BindingDB Entry DOI: 10.7270/Q29Z978Z | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Gonadotropin releasing hormone receptor (GNRHR) (Oryctolagus cuniculus (Rabbit)) | BDBM405272 (1-(4-(7-(2,6-difluorobenzyl)-3-((dimethylamino)met...) | UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.240 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co., Ltd US Patent | Assay Description Rabbit: This assay was used to determine the inhibition effect of the present compounds on the activity of rabbit GnRHr protein expressed by rabbit G... | US Patent US10344034 (2019) BindingDB Entry DOI: 10.7270/Q29Z978Z | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Gonadotropin releasing hormone receptor (GNRHR) (Oryctolagus cuniculus (Rabbit)) | BDBM405271 (1-(4-(3-((dimethylamino)methyl)-5-(2-fluoro-3-meth...) | UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.270 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co., Ltd US Patent | Assay Description Rabbit: This assay was used to determine the inhibition effect of the present compounds on the activity of rabbit GnRHr protein expressed by rabbit G... | US Patent US10344034 (2019) BindingDB Entry DOI: 10.7270/Q29Z978Z | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Gonadotropin-releasing hormone receptor (Homo sapiens (Human)) | BDBM405272 (1-(4-(7-(2,6-difluorobenzyl)-3-((dimethylamino)met...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.420 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co., Ltd US Patent | Assay Description Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin... | US Patent US10344034 (2019) BindingDB Entry DOI: 10.7270/Q29Z978Z | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Gonadotropin-releasing hormone receptor (Homo sapiens (Human)) | BDBM405278 (1-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)met...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.430 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co., Ltd US Patent | Assay Description Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin... | US Patent US10344034 (2019) BindingDB Entry DOI: 10.7270/Q29Z978Z | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Gonadotropin-releasing hormone receptor (Homo sapiens (Human)) | BDBM405270 (1-(4-(3-((dimethylamino)methyl)-5-(2-fluoro-3-meth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.490 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co., Ltd US Patent | Assay Description Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin... | US Patent US10344034 (2019) BindingDB Entry DOI: 10.7270/Q29Z978Z | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Gonadotropin releasing hormone receptor (GNRHR) (Oryctolagus cuniculus (Rabbit)) | BDBM405274 (1-(4-(7-(2,6-difluorobenzyl)-3-((dimethylamino)met...) | UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.570 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co., Ltd US Patent | Assay Description Rabbit: This assay was used to determine the inhibition effect of the present compounds on the activity of rabbit GnRHr protein expressed by rabbit G... | US Patent US10344034 (2019) BindingDB Entry DOI: 10.7270/Q29Z978Z | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Gonadotropin-releasing hormone receptor (Homo sapiens (Human)) | BDBM405271 (1-(4-(3-((dimethylamino)methyl)-5-(2-fluoro-3-meth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co., Ltd US Patent | Assay Description Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin... | US Patent US10344034 (2019) BindingDB Entry DOI: 10.7270/Q29Z978Z | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Gonadotropin-releasing hormone receptor (Homo sapiens (Human)) | BDBM405268 (1-(4-(7-(2,6-difluorobenzyl)-3-((dimethylamino)met...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.660 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co., Ltd US Patent | Assay Description Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin... | US Patent US10344034 (2019) BindingDB Entry DOI: 10.7270/Q29Z978Z | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Gonadotropin-releasing hormone receptor (Homo sapiens (Human)) | BDBM405273 (1-(4-(7-(2,6-difluorobenzyl)-3-((dimethylamino)met...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.660 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co., Ltd US Patent | Assay Description Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin... | US Patent US10344034 (2019) BindingDB Entry DOI: 10.7270/Q29Z978Z | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Gonadotropin-releasing hormone receptor (Homo sapiens (Human)) | BDBM405267 (1-(4-(7-(2,6-difluorobenzyl)-3-((dimethylamino)met...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co., Ltd US Patent | Assay Description Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin... | US Patent US10344034 (2019) BindingDB Entry DOI: 10.7270/Q29Z978Z | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Gonadotropin-releasing hormone receptor (Homo sapiens (Human)) | BDBM405276 (1-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)met...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.920 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co., Ltd US Patent | Assay Description Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin... | US Patent US10344034 (2019) BindingDB Entry DOI: 10.7270/Q29Z978Z | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Gonadotropin-releasing hormone receptor (Homo sapiens (Human)) | BDBM405269 (1-(4-(3-((dimethylamino)methyl)-5-(2-fluoro-3-meth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.960 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co., Ltd US Patent | Assay Description Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin... | US Patent US10344034 (2019) BindingDB Entry DOI: 10.7270/Q29Z978Z | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Gonadotropin-releasing hormone receptor (Homo sapiens (Human)) | BDBM405266 (1-(4-(7-(2,6-difluorobenzyl)-3-((dimethylamino)met...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.46 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co., Ltd US Patent | Assay Description Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin... | US Patent US10344034 (2019) BindingDB Entry DOI: 10.7270/Q29Z978Z | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Gonadotropin-releasing hormone receptor (Homo sapiens (Human)) | BDBM405275 (1-(4-(3-((dimethylamino)methyl)-7-(2-fluoro-6-(tri...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.24 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co., Ltd US Patent | Assay Description Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin... | US Patent US10344034 (2019) BindingDB Entry DOI: 10.7270/Q29Z978Z | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Gonadotropin-releasing hormone receptor (Homo sapiens (Human)) | BDBM405279 (1-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)met...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.32 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co., Ltd US Patent | Assay Description Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin... | US Patent US10344034 (2019) BindingDB Entry DOI: 10.7270/Q29Z978Z | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Gonadotropin-releasing hormone receptor (Homo sapiens (Human)) | BDBM405274 (1-(4-(7-(2,6-difluorobenzyl)-3-((dimethylamino)met...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.95 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co., Ltd US Patent | Assay Description Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin... | US Patent US10344034 (2019) BindingDB Entry DOI: 10.7270/Q29Z978Z | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Gonadotropin releasing hormone receptor (GNRHR) (Macaca fascicularis (Crab-eating macaque) (Cynomol...) | BDBM405272 (1-(4-(7-(2,6-difluorobenzyl)-3-((dimethylamino)met...) | PDB UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 23.2 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co., Ltd US Patent | Assay Description Monkey: This assay was used to determine the inhibition effect of the present compounds on the activity of monkey GnRHr protein expressed by monkey G... | US Patent US10344034 (2019) BindingDB Entry DOI: 10.7270/Q29Z978Z | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Gonadotropin releasing hormone receptor (GNRHR) (Macaca fascicularis (Crab-eating macaque) (Cynomol...) | BDBM405274 (1-(4-(7-(2,6-difluorobenzyl)-3-((dimethylamino)met...) | PDB UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 78.6 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co., Ltd US Patent | Assay Description Monkey: This assay was used to determine the inhibition effect of the present compounds on the activity of monkey GnRHr protein expressed by monkey G... | US Patent US10344034 (2019) BindingDB Entry DOI: 10.7270/Q29Z978Z | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
