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Patent code US10351547

Compile Data Set for Download or QSAR

Found 267 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405705
PNG
(US10351547, Compound 2-172 | US10597377, Compound ...)
Show SMILES CONC(=O)Nc1c(F)cncc1-c1ccc2ncc(-c3cc(C)cc(F)c3)c(N3CCC(N)CC3)c2c1
Show InChI InChI=1S/C28H28F2N6O2/c1-16-9-18(11-19(29)10-16)23-14-33-25-4-3-17(12-21(25)27(23)36-7-5-20(31)6-8-36)22-13-32-15-24(30)26(22)34-28(37)35-38-2/h3-4,9-15,20H,5-8,31H2,1-2H3,(H2,32,34,35,37)
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405721
PNG
(US10351547, Compound 2-188 | US10597377, Compound ...)
Show SMILES Cn1ncc(c1C=NO)-c1ccc2ncc(-c3cc(F)cc(F)c3)c(N3CCC(N)CC3)c2c1
Show InChI InChI=1S/C25H24F2N6O/c1-32-24(14-31-34)21(13-30-32)15-2-3-23-20(10-15)25(33-6-4-19(28)5-7-33)22(12-29-23)16-8-17(26)11-18(27)9-16/h2-3,8-14,19,34H,4-7,28H2,1H3/b31-14+
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405723
PNG
(US10351547, Compound 2-191 | US10597377, Compound ...)
Show SMILES CON(C)C(=O)Nc1c(cc(F)c(F)c1-c1ccc2ncc(-c3cc(F)cc(F)c3)c(N3CCC(N)CC3)c2c1)C#N
Show InChI InChI=1S/C30H26F4N6O2/c1-39(42-2)30(41)38-28-18(14-35)12-24(33)27(34)26(28)16-3-4-25-22(11-16)29(40-7-5-21(36)6-8-40)23(15-37-25)17-9-19(31)13-20(32)10-17/h3-4,9-13,15,21H,5-8,36H2,1-2H3,(H,38,41)
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405732
PNG
(US10351547, Compound 2-201 | US10597377, Compound ...)
Show SMILES COC(=O)Oc1c(cccc1-c1ccc2ncc(-c3cc(F)cc(F)c3)c(N3CCC(N)CC3)c2c1)C#N
Show InChI InChI=1S/C29H24F2N4O3/c1-37-29(36)38-28-18(15-32)3-2-4-23(28)17-5-6-26-24(13-17)27(35-9-7-22(33)8-10-35)25(16-34-26)19-11-20(30)14-21(31)12-19/h2-6,11-14,16,22H,7-10,33H2,1H3
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405735
PNG
(US10351547, Compound 2-204 | US10597377, Compound ...)
Show SMILES COCCOc1c(cc(F)cc1-c1ccc2ncc(-c3cc(C)cc(F)c3)c(N3CCC(N)CC3)c2c1)C#N
Show InChI InChI=1S/C31H30F2N4O2/c1-19-11-21(13-23(32)12-19)28-18-36-29-4-3-20(15-27(29)30(28)37-7-5-25(35)6-8-37)26-16-24(33)14-22(17-34)31(26)39-10-9-38-2/h3-4,11-16,18,25H,5-10,35H2,1-2H3
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405736
PNG
(US10351547, Compound 2-205 | US10597377, Compound ...)
Show SMILES COC(=O)Nc1c(cc(F)c(F)c1-c1ccc2ncc(-c3cc(C)cc(F)c3)c(N3CCC(N)CC3)c2c1)C#N
Show InChI InChI=1S/C30H26F3N5O2/c1-16-9-18(11-20(31)10-16)23-15-36-25-4-3-17(12-22(25)29(23)38-7-5-21(35)6-8-38)26-27(33)24(32)13-19(14-34)28(26)37-30(39)40-2/h3-4,9-13,15,21H,5-8,35H2,1-2H3,(H,37,39)
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405759
PNG
(US10351547, Compound 2-229)
Show SMILES COCCNc1nn(C)cc1-c1ccc2ncc(-c3cc(F)cc(F)c3)c(N3CCC(N)CC3)c2c1
Show InChI InChI=1S/C27H30F2N6O/c1-34-16-24(27(33-34)31-7-10-36-2)17-3-4-25-22(13-17)26(35-8-5-21(30)6-9-35)23(15-32-25)18-11-19(28)14-20(29)12-18/h3-4,11-16,21H,5-10,30H2,1-2H3,(H,31,33)
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CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405762
PNG
(US10351547, Compound 2-232 | US10597377, Compound ...)
Show SMILES COCCOc1c(cc(F)cc1-c1ccc2ncc(-c3cc(F)cc(F)c3)c(N3CC[C@H](N)[C@H](O)C3)c2c1)C#N
Show InChI InChI=1S/C30H27F3N4O3/c1-39-6-7-40-30-19(14-34)10-22(33)13-23(30)17-2-3-27-24(11-17)29(37-5-4-26(35)28(38)16-37)25(15-36-27)18-8-20(31)12-21(32)9-18/h2-3,8-13,15,26,28,38H,4-7,16,35H2,1H3/t26-,28+/m0/s1
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405777
PNG
(US10351547, Compound 2-247)
Show SMILES Cc1cc(F)cc(c1)-c1cnc2ccc(cc2c1N1CC[C@H]2OCCN[C@@H]2C1)-c1nccc(C)c1N
Show InChI InChI=1S/C29H30FN5O/c1-17-11-20(13-21(30)12-17)23-15-34-24-4-3-19(28-27(31)18(2)5-7-33-28)14-22(24)29(23)35-9-6-26-25(16-35)32-8-10-36-26/h3-5,7,11-15,25-26,32H,6,8-10,16,31H2,1-2H3/t25-,26-/m1/s1
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405782
PNG
(US10351547, Compound 2-252)
Show SMILES COCCNc1c(cncc1-c1ccc2ncc(-c3cc(C)cc(F)c3)c(N3CC[C@H]4OCCN[C@@H]4C3)c2c1)C#N
Show InChI InChI=1S/C32H33FN6O2/c1-20-11-22(13-24(33)12-20)27-18-38-28-4-3-21(26-17-35-16-23(15-34)31(26)37-6-9-40-2)14-25(28)32(27)39-8-5-30-29(19-39)36-7-10-41-30/h3-4,11-14,16-18,29-30,36H,5-10,19H2,1-2H3,(H,35,37)/t29-,30-/m1/s1
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CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405794
PNG
(US10351547, Compound 2-264)
Show SMILES Cc1cc(F)cc(c1)-c1cnc2ccc(cc2c1N1CC[C@H]2OCCN[C@@H]2C1)-c1cccc(\C=N/O)n1
Show InChI InChI=1S/C29H28FN5O2/c1-18-11-20(13-21(30)12-18)24-16-32-26-6-5-19(25-4-2-3-22(34-25)15-33-36)14-23(26)29(24)35-9-7-28-27(17-35)31-8-10-37-28/h2-6,11-16,27-28,31,36H,7-10,17H2,1H3/b33-15-/t27-,28-/m1/s1
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CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405801
PNG
(US10351547, Compound 2-271)
Show SMILES Cc1cc(F)cc(c1)-c1cnc2ccc(cc2c1N1CC(C1)C1COCCN1)-c1cccc(C#N)c1O
Show InChI InChI=1S/C30H27FN4O2/c1-18-9-21(11-23(31)10-18)26-14-34-27-6-5-19(24-4-2-3-20(13-32)30(24)36)12-25(27)29(26)35-15-22(16-35)28-17-37-8-7-33-28/h2-6,9-12,14,22,28,33,36H,7-8,15-17H2,1H3
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n/an/an/an/a 55n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405815
PNG
(US10351547, Compound 3-10 | US10597377, Compound 3...)
Show SMILES Fc1cc(F)cc(c1)-c1cnc2ccc(nc2c1N1CC[C@@H]2NCCO[C@H]2C1)-c1cc(F)c2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C28H21F3N6O2/c29-16-7-14(8-17(30)11-16)18-12-33-22-2-1-20(15-9-19(31)25-23(10-15)35-28(38)36-25)34-26(22)27(18)37-5-3-21-24(13-37)39-6-4-32-21/h1-2,7-12,21,24,32H,3-6,13H2/t21-,24-/m0/s1
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405816
PNG
(US10351547, Compound 4-1 | US10597377, Compound 4-...)
Show SMILES NC1CCN(CC1)c1c(cnc2ncc(cc12)-c1cccc(C#N)c1O)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C26H21F2N5O/c27-18-8-16(9-19(28)11-18)23-14-32-26-22(24(23)33-6-4-20(30)5-7-33)10-17(13-31-26)21-3-1-2-15(12-29)25(21)34/h1-3,8-11,13-14,20,34H,4-7,30H2
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CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405561
PNG
(US10351547, Compound 1-9 | US10597377, Compound 1-...)
Show SMILES Cc1cc(F)cc(c1)-c1nnc2cc(Cl)c(cc2c1N1CCC(N)CC1)-c1cccc2[nH]c(=O)[nH]c12
Show InChI InChI=1S/C27H24ClFN6O/c1-14-9-15(11-16(29)10-14)24-26(35-7-5-17(30)6-8-35)20-12-19(21(28)13-23(20)33-34-24)18-3-2-4-22-25(18)32-27(36)31-22/h2-4,9-13,17H,5-8,30H2,1H3,(H2,31,32,36)
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CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405564
PNG
(US10351547, Compound 1-12 | US10597377, Compound 1...)
Show SMILES Cc1cc(Cl)cc(c1)-c1nnc2cc(Cl)c(cc2c1N1CCC(N)CC1)-c1cc(F)cc(C#N)c1O
Show InChI InChI=1S/C27H22Cl2FN5O/c1-14-6-15(8-17(28)7-14)25-26(35-4-2-19(32)3-5-35)22-11-20(23(29)12-24(22)33-34-25)21-10-18(30)9-16(13-31)27(21)36/h6-12,19,36H,2-5,32H2,1H3
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405575
PNG
(US10351547, Compound 1-23 | US10597377, Compound 1...)
Show SMILES Cc1cc(Cl)cc(c1)-c1nnc2ccc(cc2c1N1CCC(N)CC1)-c1cc(F)c2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C27H24ClFN6O/c1-14-8-17(10-18(28)9-14)24-26(35-6-4-19(30)5-7-35)20-11-15(2-3-22(20)33-34-24)16-12-21(29)25-23(13-16)31-27(36)32-25/h2-3,8-13,19H,4-7,30H2,1H3,(H2,31,32,36)
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405585
PNG
(US10351547, Compound 1-33 | US10597377, Compound 1...)
Show SMILES NC(=O)c1cc(F)cc(c1)-c1ccc2nnc(-c3cc(Cl)cc(Cl)c3)c(N3CCC(CC3)NCCF)c2c1
Show InChI InChI=1S/C28H25Cl2F2N5O/c29-20-10-18(11-21(30)15-20)26-27(37-7-3-23(4-8-37)34-6-5-31)24-14-16(1-2-25(24)35-36-26)17-9-19(28(33)38)13-22(32)12-17/h1-2,9-15,23,34H,3-8H2,(H2,33,38)
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405590
PNG
(US10351547, Compound 2-4 | US10597377, Compound 2-...)
Show SMILES CO[C@@H]1CN(CC[C@H]1N)c1c(cnc2ccc(cc12)-c1cccc(c1)C#N)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C28H24F2N4O/c1-35-27-16-34(8-7-25(27)32)28-23-12-19(18-4-2-3-17(9-18)14-31)5-6-26(23)33-15-24(28)20-10-21(29)13-22(30)11-20/h2-6,9-13,15,25,27H,7-8,16,32H2,1H3/t25-,27-/m1/s1
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405593
PNG
(US10351547, Compound 2-7 | US10597377, Compound 2-...)
Show SMILES Cc1cc(F)cc(c1)-c1cnc2ccc(cc2c1N1CCC(N)CC1)-c1cccc(n1)C(N)=O
Show InChI InChI=1S/C27H26FN5O/c1-16-11-18(13-19(28)12-16)22-15-31-24-6-5-17(23-3-2-4-25(32-23)27(30)34)14-21(24)26(22)33-9-7-20(29)8-10-33/h2-6,11-15,20H,7-10,29H2,1H3,(H2,30,34)
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405619
PNG
(US10351547, Compound 2-35 | US10597377, Compound 2...)
Show SMILES Cc1cc(F)cc(c1)-c1cnc2ccc(cc2c1N1CC(CN2CCOCC2)C1)-c1cc(F)cc(C#N)c1O
Show InChI InChI=1S/C31H28F2N4O2/c1-19-8-22(10-24(32)9-19)28-15-35-29-3-2-21(26-13-25(33)11-23(14-34)31(26)38)12-27(29)30(28)37-17-20(18-37)16-36-4-6-39-7-5-36/h2-3,8-13,15,20,38H,4-7,16-18H2,1H3
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CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405622
PNG
(US10351547, Compound 2-40 | US10597377, Compound 2...)
Show SMILES Cc1cc(F)cc(c1)-c1cnc2ccc(cc2c1N1CC(CNCC(C)(C)O)C1)-c1cc(F)cc(C#N)c1O
Show InChI InChI=1S/C31H30F2N4O2/c1-18-6-21(8-23(32)7-18)27-14-36-28-5-4-20(25-11-24(33)9-22(12-34)30(25)38)10-26(28)29(27)37-15-19(16-37)13-35-17-31(2,3)39/h4-11,14,19,35,38-39H,13,15-17H2,1-3H3
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CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405624
PNG
(US10351547, Compound 2-42 | US10597377, Compound 2...)
Show SMILES CCCNCC1CN(C1)c1c(cnc2ccc(cc12)-c1cccc(C#N)c1O)-c1cc(C)cc(F)c1
Show InChI InChI=1S/C30H29FN4O/c1-3-9-33-15-20-17-35(18-20)29-26-13-21(25-6-4-5-22(14-32)30(25)36)7-8-28(26)34-16-27(29)23-10-19(2)11-24(31)12-23/h4-8,10-13,16,20,33,36H,3,9,15,17-18H2,1-2H3
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CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405625
PNG
(US10351547, Compound 2-43 | US10597377, Compound 2...)
Show SMILES Cc1cc(F)cc(c1)-c1cnc2ccc(cc2c1N1CC(CNCCO)C1)-c1cc(F)cc(C#N)c1O
Show InChI InChI=1S/C29H26F2N4O2/c1-17-6-20(8-22(30)7-17)26-14-34-27-3-2-19(24-11-23(31)9-21(12-32)29(24)37)10-25(27)28(26)35-15-18(16-35)13-33-4-5-36/h2-3,6-11,14,18,33,36-37H,4-5,13,15-16H2,1H3
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CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405641
PNG
(US10351547, Compound 2-59 | US10597377, Compound 2...)
Show SMILES N[C@@H]1CCN(C[C@H]1F)c1c(cnc2ccc(cc12)-c1cccc(C#N)c1O)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C27H21F3N4O/c28-18-8-17(9-19(29)11-18)22-13-33-25-5-4-15(20-3-1-2-16(12-31)27(20)35)10-21(25)26(22)34-7-6-24(32)23(30)14-34/h1-5,8-11,13,23-24,35H,6-7,14,32H2/t23-,24-/m1/s1
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CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405652
PNG
(US10351547, Compound 2-70 | US10597377, Compound 2...)
Show SMILES CO\N=C\c1cc(F)cc(c1)-c1cnc2ccc(cc2c1N1CCC(N)CC1)-c1cccc(C#N)c1O
Show InChI InChI=1S/C29H26FN5O2/c1-37-34-16-18-11-21(13-22(30)12-18)26-17-33-27-6-5-19(24-4-2-3-20(15-31)29(24)36)14-25(27)28(26)35-9-7-23(32)8-10-35/h2-6,11-14,16-17,23,36H,7-10,32H2,1H3/b34-16+
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CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405654
PNG
(US10351547, Compound 2-72 | US10597377, Compound 2...)
Show SMILES COCCOc1c(cccc1-c1ccc2ncc(-c3cc(F)cc(F)c3)c(N3CCC(N)CC3)c2c1)C#N
Show InChI InChI=1S/C30H28F2N4O2/c1-37-11-12-38-30-20(17-33)3-2-4-25(30)19-5-6-28-26(15-19)29(36-9-7-24(34)8-10-36)27(18-35-28)21-13-22(31)16-23(32)14-21/h2-6,13-16,18,24H,7-12,34H2,1H3
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CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405656
PNG
(US10351547, Compound 2-74 | US10351547, Compound 2...)
Show SMILES NC1CCN(CC1)c1c(cnc2ccc(cc12)-c1cncc(F)c1OC1COC1)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C28H25F3N4O2/c29-18-7-17(8-19(30)10-18)23-12-34-26-2-1-16(9-22(26)27(23)35-5-3-20(32)4-6-35)24-11-33-13-25(31)28(24)37-21-14-36-15-21/h1-2,7-13,20-21H,3-6,14-15,32H2
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CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405668
PNG
(US10351547, Compound 2-86 | US10597377, Compound 2...)
Show SMILES CS(=O)(=O)Nc1c(F)cc(F)cc1-c1ccc2ncc(-c3cc(F)cc(F)c3)c(N3CCC(N)CC3)c2c1
Show InChI InChI=1S/C27H24F4N4O2S/c1-38(36,37)34-26-21(12-19(30)13-24(26)31)15-2-3-25-22(10-15)27(35-6-4-20(32)5-7-35)23(14-33-25)16-8-17(28)11-18(29)9-16/h2-3,8-14,20,34H,4-7,32H2,1H3
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CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405669
PNG
(US10351547, Compound 2-87 | US10597377, Compound 2...)
Show SMILES COCCOCOc1c(cccc1-c1ccc2ncc(-c3cc(F)cc(F)c3)c(N3CCC(N)CC3)c2c1)C#N
Show InChI InChI=1S/C31H30F2N4O3/c1-38-11-12-39-19-40-31-21(17-34)3-2-4-26(31)20-5-6-29-27(15-20)30(37-9-7-25(35)8-10-37)28(18-36-29)22-13-23(32)16-24(33)14-22/h2-6,13-16,18,25H,7-12,19,35H2,1H3
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CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405675
PNG
(US10351547, Compound 2-115 | US10597377, Compound ...)
Show SMILES CON=Cc1cccc(c1O)-c1ccc2ncc(-c3cc(C)cc(F)c3)c(N3CCC(N)CC3)c2c1
Show InChI InChI=1S/C29H29FN4O2/c1-18-12-21(14-22(30)13-18)26-17-32-27-7-6-19(24-5-3-4-20(29(24)35)16-33-36-2)15-25(27)28(26)34-10-8-23(31)9-11-34/h3-7,12-17,23,35H,8-11,31H2,1-2H3/b33-16+
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CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405692
PNG
(US10351547, Compound 2-149 | US10597377, Compound ...)
Show SMILES CNC(=O)[C@@H]1CN(CC[C@H]1N)c1c(cnc2ccc(cc12)-c1cccc(C#N)c1O)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C29H25F2N5O2/c1-34-29(38)24-15-36(8-7-25(24)33)27-22-11-16(21-4-2-3-17(13-32)28(21)37)5-6-26(22)35-14-23(27)18-9-19(30)12-20(31)10-18/h2-6,9-12,14,24-25,37H,7-8,15,33H2,1H3,(H,34,38)/t24-,25-/m1/s1
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CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405700
PNG
(US10351547, Compound 2-167 | US10597377, Compound ...)
Show SMILES COC(=O)Nc1c(cccc1-c1ccc2ncc(-c3cc(F)cc(OC)c3)c(N3CCC(N)CC3)c2c1)C#N
Show InChI InChI=1S/C30H28FN5O3/c1-38-23-13-20(12-21(31)15-23)26-17-34-27-7-6-18(14-25(27)29(26)36-10-8-22(33)9-11-36)24-5-3-4-19(16-32)28(24)35-30(37)39-2/h3-7,12-15,17,22H,8-11,33H2,1-2H3,(H,35,37)
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CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405713
PNG
(US10351547, Compound 2-180 | US10597377, Compound ...)
Show SMILES COC(=O)Nc1c(cc(F)c(F)c1-c1ccc2ncc(-c3cc(F)cc(F)c3)c(N3CCC(N)CC3)c2c1)C#N
Show InChI InChI=1S/C29H23F4N5O2/c1-40-29(39)37-27-17(13-34)11-23(32)26(33)25(27)15-2-3-24-21(10-15)28(38-6-4-20(35)5-7-38)22(14-36-24)16-8-18(30)12-19(31)9-16/h2-3,8-12,14,20H,4-7,35H2,1H3,(H,37,39)
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CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405720
PNG
(US10351547, Compound 2-187 | US10597377, Compound ...)
Show SMILES Cc1cc(F)cc(c1)-c1cnc2ccc(cc2c1N1CCC(N)CC1)-c1cncc(C#N)c1N
Show InChI InChI=1S/C27H25FN6/c1-16-8-18(10-20(28)9-16)24-15-33-25-3-2-17(23-14-32-13-19(12-29)26(23)31)11-22(25)27(24)34-6-4-21(30)5-7-34/h2-3,8-11,13-15,21H,4-7,30H2,1H3,(H2,31,32)
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CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405722
PNG
(US10351547, Compound 2-189 | US10597377, Compound ...)
Show SMILES CONC(=O)Nc1ccc(cc1-c1ccc2ncc(-c3cc(F)cc(F)c3)c(N3CCC(N)CC3)c2c1)C#N
Show InChI InChI=1S/C29H26F2N6O2/c1-39-36-29(38)35-27-4-2-17(15-32)10-23(27)18-3-5-26-24(13-18)28(37-8-6-22(33)7-9-37)25(16-34-26)19-11-20(30)14-21(31)12-19/h2-5,10-14,16,22H,6-9,33H2,1H3,(H2,35,36,38)
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CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405728
PNG
(US10351547, Compound 2-197 | US10597377, Compound ...)
Show SMILES COC(=O)Nc1c(F)cc(F)cc1-c1ccc2ncc(-c3cc(C)cc(F)c3)c(N3CCC(N)CC3)c2c1
Show InChI InChI=1S/C29H27F3N4O2/c1-16-9-18(11-19(30)10-16)24-15-34-26-4-3-17(12-23(26)28(24)36-7-5-21(33)6-8-36)22-13-20(31)14-25(32)27(22)35-29(37)38-2/h3-4,9-15,21H,5-8,33H2,1-2H3,(H,35,37)
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405731
PNG
(US10351547, Compound 2-200 | US10597377, Compound ...)
Show SMILES NC1CCN(CC1)c1c(cnc2ccc(cc12)-c1cccc(C=NO)n1)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C26H23F2N5O/c27-18-10-17(11-19(28)13-18)23-15-30-25-5-4-16(24-3-1-2-21(32-24)14-31-34)12-22(25)26(23)33-8-6-20(29)7-9-33/h1-5,10-15,20,34H,6-9,29H2/b31-14+
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405743
PNG
(US10351547, Compound 2-213 | US10597377, Compound ...)
Show SMILES CON=Cc1cc(ccc1O)-c1ccc2ncc(-c3cc(C)cc(F)c3)c(N3CCC(N)CC3)c2c1
Show InChI InChI=1S/C29H29FN4O2/c1-18-11-21(14-23(30)12-18)26-17-32-27-5-3-20(19-4-6-28(35)22(13-19)16-33-36-2)15-25(27)29(26)34-9-7-24(31)8-10-34/h3-6,11-17,24,35H,7-10,31H2,1-2H3/b33-16+
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n/an/an/an/a 55n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405747
PNG
(US10351547, Compound 2-217)
Show SMILES CO[C@@H]1CN(CC[C@H]1N)c1c(cnc2ccc(cc12)-c1cccc(F)c1C=NO)-c1cc(C)cc(F)c1
Show InChI InChI=1S/C29H28F2N4O2/c1-17-10-19(12-20(30)11-17)23-14-33-27-7-6-18(21-4-3-5-25(31)24(21)15-34-36)13-22(27)29(23)35-9-8-26(32)28(16-35)37-2/h3-7,10-15,26,28,36H,8-9,16,32H2,1-2H3/b34-15-/t26-,28-/m1/s1
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405753
PNG
(US10351547, Compound 2-223 | US10597377, Compound ...)
Show SMILES CONC(=O)Nc1cc(F)cc(c1)-c1ccc2ncc(-c3cc(C)cc(F)c3)c(N3CCC(N)CC3)c2c1
Show InChI InChI=1S/C29H29F2N5O2/c1-17-9-20(12-21(30)10-17)26-16-33-27-4-3-18(14-25(27)28(26)36-7-5-23(32)6-8-36)19-11-22(31)15-24(13-19)34-29(37)35-38-2/h3-4,9-16,23H,5-8,32H2,1-2H3,(H2,34,35,37)
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405757
PNG
(US10351547, Compound 2-227 | US10597377, Compound ...)
Show SMILES Cc1cc(F)cc(c1)-c1cnc2ccc(cc2c1N1CC[C@H](N)[C@H](O)C1)-c1cccc(F)c1C=NO
Show InChI InChI=1S/C28H26F2N4O2/c1-16-9-18(11-19(29)10-16)22-13-32-26-6-5-17(20-3-2-4-24(30)23(20)14-33-36)12-21(26)28(22)34-8-7-25(31)27(35)15-34/h2-6,9-14,25,27,35-36H,7-8,15,31H2,1H3/b33-14+/t25-,27+/m0/s1
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405760
PNG
(US10351547, Compound 2-230 | US10597377, Compound ...)
Show SMILES COCC(=O)Nc1c(F)cc(F)cc1-c1ccc2ncc(-c3cc(C)cc(F)c3)c(N3CCC(N)CC3)c2c1
Show InChI InChI=1S/C30H29F3N4O2/c1-17-9-19(11-20(31)10-17)25-15-35-27-4-3-18(12-24(27)30(25)37-7-5-22(34)6-8-37)23-13-21(32)14-26(33)29(23)36-28(38)16-39-2/h3-4,9-15,22H,5-8,16,34H2,1-2H3,(H,36,38)
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405764
PNG
(US10351547, Compound 2-234 | US10597377, Compound ...)
Show SMILES COCCNc1ncc(F)cc1-c1ccc2ncc(-c3cc(C)cc(F)c3)c(N3CCC(N)CC3)c2c1
Show InChI InChI=1S/C29H31F2N5O/c1-18-11-20(13-21(30)12-18)26-17-34-27-4-3-19(14-25(27)28(26)36-8-5-23(32)6-9-36)24-15-22(31)16-35-29(24)33-7-10-37-2/h3-4,11-17,23H,5-10,32H2,1-2H3,(H,33,35)
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405793
PNG
(US10351547, Compound 2-263)
Show SMILES Cc1cc(F)cc(c1)-c1cnc2ccc(cc2c1N1CC[C@H]2OCCN[C@@H]2C1)-c1ncccc1O
Show InChI InChI=1S/C28H27FN4O2/c1-17-11-19(13-20(29)12-17)22-15-32-23-5-4-18(27-25(34)3-2-7-31-27)14-21(23)28(22)33-9-6-26-24(16-33)30-8-10-35-26/h2-5,7,11-15,24,26,30,34H,6,8-10,16H2,1H3/t24-,26-/m1/s1
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405796
PNG
(US10351547, Compound 2-266)
Show SMILES CO\N=C\Cc1cncc(c1N)-c1ccc2ncc(-c3cc(C)cc(F)c3)c(N3CC[C@H]4OCCN[C@@H]4C3)c2c1
Show InChI InChI=1S/C31H33FN6O2/c1-19-11-22(13-23(32)12-19)26-17-36-27-4-3-20(25-16-34-15-21(30(25)33)5-7-37-39-2)14-24(27)31(26)38-9-6-29-28(18-38)35-8-10-40-29/h3-4,7,11-17,28-29,35H,5-6,8-10,18H2,1-2H3,(H2,33,34)/b37-7+/t28-,29-/m1/s1
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405812
PNG
(US10351547, Compound 3-4 | US10597377, Compound 3-...)
Show SMILES Cc1cc(F)cc(c1)-c1cnc2ccc(nc2c1N1CCC(N)CC1)-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C27H25FN6O/c1-15-10-17(12-18(28)11-15)20-14-30-23-5-4-21(16-2-3-22-24(13-16)33-27(35)32-22)31-25(23)26(20)34-8-6-19(29)7-9-34/h2-5,10-14,19H,6-9,29H2,1H3,(H2,32,33,35)
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405813
PNG
(US10351547, Compound 3-5 | US10597377, Compound 3-...)
Show SMILES Cc1cc(F)cc(c1)-c1cnc2ccc(nc2c1N1CCC(N)CC1)-c1cc(F)c2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C27H24F2N6O/c1-14-8-15(10-17(28)9-14)19-13-31-22-3-2-21(16-11-20(29)24-23(12-16)33-27(36)34-24)32-25(22)26(19)35-6-4-18(30)5-7-35/h2-3,8-13,18H,4-7,30H2,1H3,(H2,33,34,36)
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405818
PNG
(US10351547, Compound 4-3 | US10597377, Compound 4-...)
Show SMILES Cc1cc(F)cc(c1)-c1cnc2ncc(cc2c1N1CCC(N)CC1)-c1cc(F)cc(C#N)c1O
Show InChI InChI=1S/C27H23F2N5O/c1-15-6-16(8-19(28)7-15)24-14-33-27-23(25(24)34-4-2-21(31)3-5-34)10-18(13-32-27)22-11-20(29)9-17(12-30)26(22)35/h6-11,13-14,21,35H,2-5,31H2,1H3
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Somatostatin receptor type 2


(Homo sapiens (Human))
BDBM405558
PNG
(US10351547, Compound 1-6 | US10597377, Compound 1-...)
Show SMILES Cc1cc(F)cc(c1)-c1nnc2cc(Cl)c(cc2c1N1CC[C@H](N)[C@H](F)C1)-c1cc(F)cc(c1)C(N)=O
Show InChI InChI=1S/C27H23ClF3N5O/c1-13-4-15(8-17(29)5-13)25-26(36-3-2-23(32)22(31)12-36)20-10-19(21(28)11-24(20)34-35-25)14-6-16(27(33)37)9-18(30)7-14/h4-11,22-23H,2-3,12,32H2,1H3,(H2,33,37)/t22-,23+/m1/s1
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n/an/an/an/a<10n/an/an/an/a



CRINETICS PHARMACEUTICALS, INC.

US Patent


Assay Description
Four days prior to the assay, 5,000 Chinese hamster ovary cells (CHO-K1, ATCC #CCL-61) stably expressing the human SSTR2 are plated in each well of a...


US Patent US10351547 (2019)


BindingDB Entry DOI: 10.7270/Q22F7QSC
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 267 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%