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Patent code US10351548

Compile Data Set for Download or QSAR
Found 11 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (Human))
BDBM405822
PNG
(US10351548, Compound IB36)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCC(=O)Nc3ccc4NC(=O)C(=Cc5cccs5)c4c3)c2=O)cc1F
Show InChI InChI=1S/C28H20F2N4O4S/c29-22-7-5-16(11-23(22)30)15-34-9-1-4-19(28(34)38)26(36)31-14-25(35)32-17-6-8-24-20(12-17)21(27(37)33-24)13-18-3-2-10-39-18/h1-13H,14-15H2,(H,31,36)(H,32,35)(H,33,37)/b21-13-
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US Patent
n/an/a 19n/an/an/an/an/an/a



International Society for Drug Development S.R.L.

US Patent


Assay Description
Factor IX is a key component of the plasma system that forms a fibrin clot at a site of vascular injury. The activity of Factor IXa is measured by mo...


US Patent US10351548 (2019)


BindingDB Entry DOI: 10.7270/Q2XP7781
More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (Human))
BDBM405827
PNG
(US10351548, Compound DD21)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCCC(=O)Nc3ccc4NC(=O)\C(=C/c5cnc[nH]5)c4c3)c2=O)cc1F
Show InChI InChI=1S/C28H22F2N6O4/c29-22-5-3-16(10-23(22)30)14-36-9-1-2-19(28(36)40)26(38)32-8-7-25(37)34-17-4-6-24-20(11-17)21(27(39)35-24)12-18-13-31-15-33-18/h1-6,9-13,15H,7-8,14H2,(H,31,33)(H,32,38)(H,34,37)(H,35,39)/b21-12-
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n/an/a 103n/an/an/an/an/an/a



International Society for Drug Development S.R.L.

US Patent


Assay Description
Factor IX is a key component of the plasma system that forms a fibrin clot at a site of vascular injury. The activity of Factor IXa is measured by mo...


US Patent US10351548 (2019)


BindingDB Entry DOI: 10.7270/Q2XP7781
More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (Human))
BDBM50185001
PNG
(CHEMBL3824119 | US10351548, Compound IB35)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCC(=O)Nc3ccc4NC(=O)\C(=C/c5cnc[nH]5)c4c3)c2=O)cc1F
Show InChI InChI=1S/C27H20F2N6O4/c28-21-5-3-15(8-22(21)29)13-35-7-1-2-18(27(35)39)25(37)31-12-24(36)33-16-4-6-23-19(9-16)20(26(38)34-23)10-17-11-30-14-32-17/h1-11,14H,12-13H2,(H,30,32)(H,31,37)(H,33,36)(H,34,38)/b20-10-
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US Patent
n/an/a 112n/an/an/an/an/an/a



International Society for Drug Development S.R.L.

US Patent


Assay Description
Factor IX is a key component of the plasma system that forms a fibrin clot at a site of vascular injury. The activity of Factor IXa is measured by mo...


US Patent US10351548 (2019)


BindingDB Entry DOI: 10.7270/Q2XP7781
More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (Human))
BDBM405828
PNG
(US10351548, Compound DD40)
Show SMILES Fc1ccc(Cn2cccc(C(=O)Nc3cccc(c3)C(=O)Nc3ccc4NC(=O)\C(=C/c5cnc[nH]5)c4c3)c2=O)cc1F
Show InChI InChI=1S/C32H22F2N6O4/c33-26-8-6-18(11-27(26)34)16-40-10-2-5-23(32(40)44)30(42)38-20-4-1-3-19(12-20)29(41)37-21-7-9-28-24(13-21)25(31(43)39-28)14-22-15-35-17-36-22/h1-15,17H,16H2,(H,35,36)(H,37,41)(H,38,42)(H,39,43)/b25-14-
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n/an/a 245n/an/an/an/an/an/a



International Society for Drug Development S.R.L.

US Patent


Assay Description
Factor IX is a key component of the plasma system that forms a fibrin clot at a site of vascular injury. The activity of Factor IXa is measured by mo...


US Patent US10351548 (2019)


BindingDB Entry DOI: 10.7270/Q2XP7781
More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (Human))
BDBM405829
PNG
(US10351548, Compound DF8)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCCCC(=O)Nc3ccc4NC(=O)\C(=C/c5cnc[nH]5)c4c3)c2=O)cc1F
Show InChI InChI=1S/C29H24F2N6O4/c30-23-7-5-17(11-24(23)31)15-37-10-2-3-20(29(37)41)27(39)33-9-1-4-26(38)35-18-6-8-25-21(12-18)22(28(40)36-25)13-19-14-32-16-34-19/h2-3,5-8,10-14,16H,1,4,9,15H2,(H,32,34)(H,33,39)(H,35,38)(H,36,40)/b22-13-
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n/an/a 245n/an/an/an/an/an/a



International Society for Drug Development S.R.L.

US Patent


Assay Description
Factor IX is a key component of the plasma system that forms a fibrin clot at a site of vascular injury. The activity of Factor IXa is measured by mo...


US Patent US10351548 (2019)


BindingDB Entry DOI: 10.7270/Q2XP7781
More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (Human))
BDBM50185000
PNG
(CHEMBL3823844 | US10351548, Compound SA16)
Show SMILES Fc1ccc(Cn2cccc(C(=O)N[C@@H](C(=O)Nc3ccc4NC(=O)\C(=C/c5cnc[nH]5)c4c3)c3ccccc3)c2=O)cc1F
Show InChI InChI=1S/C33H24F2N6O4/c34-26-10-8-19(13-27(26)35)17-41-12-4-7-23(33(41)45)30(42)40-29(20-5-2-1-3-6-20)32(44)38-21-9-11-28-24(14-21)25(31(43)39-28)15-22-16-36-18-37-22/h1-16,18,29H,17H2,(H,36,37)(H,38,44)(H,39,43)(H,40,42)/b25-15-/t29-/m1/s1
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n/an/a 416n/an/an/an/an/an/a



International Society for Drug Development S.R.L.

US Patent


Assay Description
Factor IX is a key component of the plasma system that forms a fibrin clot at a site of vascular injury. The activity of Factor IXa is measured by mo...


US Patent US10351548 (2019)


BindingDB Entry DOI: 10.7270/Q2XP7781
More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (Human))
BDBM50185003
PNG
(CHEMBL3824264 | US10351548, Compound JJ31)
Show SMILES Fc1ccc(Cn2cccc(C(=O)Nc3ccc4NC(=O)\C(=C/c5cnc[nH]5)c4c3)c2=O)cc1F
Show InChI InChI=1S/C25H17F2N5O3/c26-20-5-3-14(8-21(20)27)12-32-7-1-2-17(25(32)35)23(33)30-15-4-6-22-18(9-15)19(24(34)31-22)10-16-11-28-13-29-16/h1-11,13H,12H2,(H,28,29)(H,30,33)(H,31,34)/b19-10-
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n/an/a 512n/an/an/an/an/an/a



International Society for Drug Development S.R.L.

US Patent


Assay Description
Factor IX is a key component of the plasma system that forms a fibrin clot at a site of vascular injury. The activity of Factor IXa is measured by mo...


US Patent US10351548 (2019)


BindingDB Entry DOI: 10.7270/Q2XP7781
More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (Human))
BDBM405826
PNG
(US10351548, Compound DD22)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCCC(=O)Nc3ccc4NC(=O)\C(=C/c5cccs5)c4c3)c2=O)cc1F
Show InChI InChI=1S/C29H22F2N4O4S/c30-23-7-5-17(13-24(23)31)16-35-11-1-4-20(29(35)39)27(37)32-10-9-26(36)33-18-6-8-25-21(14-18)22(28(38)34-25)15-19-3-2-12-40-19/h1-8,11-15H,9-10,16H2,(H,32,37)(H,33,36)(H,34,38)/b22-15-
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n/an/a 1.34E+3n/an/an/an/an/an/a



International Society for Drug Development S.R.L.

US Patent


Assay Description
Factor IX is a key component of the plasma system that forms a fibrin clot at a site of vascular injury. The activity of Factor IXa is measured by mo...


US Patent US10351548 (2019)


BindingDB Entry DOI: 10.7270/Q2XP7781
More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (Human))
BDBM50184999
PNG
(CHEMBL3823622 | US10351548, Compound SA23)
Show SMILES Fc1ccc(Cn2cccc(C(=O)N[C@@H](C(=O)Nc3ccc4NC(=O)\C(=C/c5ncc[nH]5)c4c3)c3ccccc3)c2=O)cc1F
Show InChI InChI=1S/C33H24F2N6O4/c34-25-10-8-19(15-26(25)35)18-41-14-4-7-22(33(41)45)30(42)40-29(20-5-2-1-3-6-20)32(44)38-21-9-11-27-23(16-21)24(31(43)39-27)17-28-36-12-13-37-28/h1-17,29H,18H2,(H,36,37)(H,38,44)(H,39,43)(H,40,42)/b24-17-/t29-/m1/s1
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n/an/a 1.52E+3n/an/an/an/an/an/a



International Society for Drug Development S.R.L.

US Patent


Assay Description
Factor IX is a key component of the plasma system that forms a fibrin clot at a site of vascular injury. The activity of Factor IXa is measured by mo...


US Patent US10351548 (2019)


BindingDB Entry DOI: 10.7270/Q2XP7781
More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (Human))
BDBM405830
PNG
(US10351548, Compound DF9)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCCCC(=O)Nc3ccc4NC(=O)C(=Cc5cccs5)c4c3)c2=O)cc1F
Show InChI InChI=1S/C30H24F2N4O4S/c31-24-9-7-18(14-25(24)32)17-36-12-2-5-21(30(36)40)28(38)33-11-1-6-27(37)34-19-8-10-26-22(15-19)23(29(39)35-26)16-20-4-3-13-41-20/h2-5,7-10,12-16H,1,6,11,17H2,(H,33,38)(H,34,37)(H,35,39)/b23-16-
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n/an/a 5.88E+3n/an/an/an/an/an/a



International Society for Drug Development S.R.L.

US Patent


Assay Description
Factor IX is a key component of the plasma system that forms a fibrin clot at a site of vascular injury. The activity of Factor IXa is measured by mo...


US Patent US10351548 (2019)


BindingDB Entry DOI: 10.7270/Q2XP7781
More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (Human))
BDBM50185002
PNG
(CHEMBL3822974 | US10351548, Compound IB32)
Show SMILES Fc1ccc(Cn2cccc(C(=O)NCC(=O)Nc3ccc4NC(=O)Cc4c3)c2=O)cc1F
Show InChI InChI=1S/C23H18F2N4O4/c24-17-5-3-13(8-18(17)25)12-29-7-1-2-16(23(29)33)22(32)26-11-21(31)27-15-4-6-19-14(9-15)10-20(30)28-19/h1-9H,10-12H2,(H,26,32)(H,27,31)(H,28,30)
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n/an/a 6.68E+3n/an/an/an/an/an/a



International Society for Drug Development S.R.L.

US Patent


Assay Description
Factor IX is a key component of the plasma system that forms a fibrin clot at a site of vascular injury. The activity of Factor IXa is measured by mo...


US Patent US10351548 (2019)


BindingDB Entry DOI: 10.7270/Q2XP7781
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%