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Patent code US10351575

Compile Data Set for Download or QSAR
Found 161 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406077
PNG
(US10351575, Example 31)
Show SMILES Cc1nn(c(NC(=O)NC2CN(CC(F)(F)F)Cc3ccccc23)c1C(N)=O)-c1ccccc1
Show InChI InChI=1S/C23H23F3N6O2/c1-14-19(20(27)33)21(32(30-14)16-8-3-2-4-9-16)29-22(34)28-18-12-31(13-23(24,25)26)11-15-7-5-6-10-17(15)18/h2-10,18H,11-13H2,1H3,(H2,27,33)(H2,28,29,34)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406081
PNG
(US10351575, Example 35A | US10351575, Example 35B)
Show SMILES COCc1ccc2OC3(CCC3)CC(NC(=O)Nc3c(C)c(nn3-c3ccccc3)-c3cnn(C)c3)c2c1
Show InChI InChI=1S/C29H32N6O3/c1-19-26(21-16-30-34(2)17-21)33-35(22-8-5-4-6-9-22)27(19)32-28(36)31-24-15-29(12-7-13-29)38-25-11-10-20(18-37-3)14-23(24)25/h4-6,8-11,14,16-17,24H,7,12-13,15,18H2,1-3H3,(H2,31,32,36)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406111
PNG
(US10351575, Example 63)
Show SMILES Cc1c(NC(=O)NC2[C@H](O)C3(CC3)c3ccc(F)cc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C26H25FN6O2/c1-15-21(16-13-28-32(2)14-16)31-33(18-6-4-3-5-7-18)24(15)30-25(35)29-22-19-12-17(27)8-9-20(19)26(10-11-26)23(22)34/h3-9,12-14,22-23,34H,10-11H2,1-2H3,(H2,29,30,35)/t22?,23-/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406124
PNG
(US10351575, Example 76)
Show SMILES CN1CCO[C@H](COc2nn(c(NC(=O)N[C@H]3[C@H](O)CC(C)(C)c4ccccc34)c2C)-c2ccccc2)C1
Show InChI InChI=1S/C29H37N5O4/c1-19-26(31-28(36)30-25-22-12-8-9-13-23(22)29(2,3)16-24(25)35)34(20-10-6-5-7-11-20)32-27(19)38-18-21-17-33(4)14-15-37-21/h5-13,21,24-25,35H,14-18H2,1-4H3,(H2,30,31,36)/t21-,24+,25+/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406126
PNG
(US10351575, Example 78)
Show SMILES CN1CCO[C@@H](COc2nn(c(NC(=O)NC3[C@@H](O)C4(CC4)c4ccccc34)c2C)-c2ccccc2)C1
Show InChI InChI=1S/C28H33N5O4/c1-18-25(30-27(35)29-23-21-10-6-7-11-22(21)28(12-13-28)24(23)34)33(19-8-4-3-5-9-19)31-26(18)37-17-20-16-32(2)14-15-36-20/h3-11,20,23-24,34H,12-17H2,1-2H3,(H2,29,30,35)/t20-,23?,24-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406128
PNG
(US10351575, Example 80)
Show SMILES Cc1c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C27H28F2N6O2/c1-15-23(16-13-30-34(4)14-16)33-35(17-8-6-5-7-9-17)25(15)32-26(37)31-24-18-10-20(28)21(29)11-19(18)27(2,3)12-22(24)36/h5-11,13-14,22,24,36H,12H2,1-4H3,(H2,31,32,37)/t22-,24-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406133
PNG
(US10351575, Example 84)
Show SMILES Cc1c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)n(nc1-c1cnc(C)nc1)-c1ccccc1
Show InChI InChI=1S/C28H28F2N6O2/c1-15-24(17-13-31-16(2)32-14-17)35-36(18-8-6-5-7-9-18)26(15)34-27(38)33-25-19-10-21(29)22(30)11-20(19)28(3,4)12-23(25)37/h5-11,13-14,23,25,37H,12H2,1-4H3,(H2,33,34,38)/t23-,25-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406137
PNG
(US10351575, Example 88)
Show SMILES CNC(=O)c1nn(c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)ccc23)c1C)-c1ccccc1
Show InChI InChI=1S/C25H28FN5O3/c1-14-20(23(33)27-4)30-31(16-8-6-5-7-9-16)22(14)29-24(34)28-21-17-11-10-15(26)12-18(17)25(2,3)13-19(21)32/h5-12,19,21,32H,13H2,1-4H3,(H,27,33)(H2,28,29,34)/t19-,21-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406163
PNG
(1-(6-(methoxymethyl)-1- methyl-2-(2,2,2- trifluoro...)
Show SMILES COCc1ccc2C(C)N(CC(F)(F)F)CC(NC(=O)Nc3c(C)c(nn3-c3ccccc3)-c3cn(C)cn3)c2c1
Show InChI InChI=1S/C29H32F3N7O2/c1-18-26(25-13-37(3)17-33-25)36-39(21-8-6-5-7-9-21)27(18)35-28(40)34-24-14-38(16-29(30,31)32)19(2)22-11-10-20(15-41-4)12-23(22)24/h5-13,17,19,24H,14-16H2,1-4H3,(H2,34,35,40)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406168
PNG
(1-(1',4-dimethyl-1- phenyl-1H,1'H-[3,4'- bipyrazol...)
Show SMILES Cc1c(NC(=O)NC2CN(CC(F)(F)F)C(=O)c3ccccc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C26H24F3N7O2/c1-16-22(17-12-30-34(2)13-17)33-36(18-8-4-3-5-9-18)23(16)32-25(38)31-21-14-35(15-26(27,28)29)24(37)20-11-7-6-10-19(20)21/h3-13,21H,14-15H2,1-2H3,(H2,31,32,38)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406171
PNG
(1-(trans-2-hydroxy- 1,2,3,4- tetrahydronaphthalen-...)
Show SMILES COc1ncc(cn1)-c1nn(c(NC(=O)NC2[C@H](O)CCc3ccccc23)c1C)-c1ccccc1
Show InChI InChI=1S/C26H26N6O3/c1-16-22(18-14-27-26(35-2)28-15-18)31-32(19-9-4-3-5-10-19)24(16)30-25(34)29-23-20-11-7-6-8-17(20)12-13-21(23)33/h3-11,14-15,21,23,33H,12-13H2,1-2H3,(H2,29,30,34)/t21-,23?/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406186
PNG
(US10351575, Example 132)
Show SMILES Cc1c(OC2CN3CCC2CC3)nn(c1NC(=O)N[C@H]1[C@H](O)CC(C)(C)c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C30H37N5O3/c1-19-27(32-29(37)31-26-22-11-7-8-12-23(22)30(2,3)17-24(26)36)35(21-9-5-4-6-10-21)33-28(19)38-25-18-34-15-13-20(25)14-16-34/h4-12,20,24-26,36H,13-18H2,1-3H3,(H2,31,32,37)/t24-,25?,26-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406188
PNG
(US10351575, Example 134)
Show SMILES CN(C)CCOc1nn(c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c1C)-c1ccccc1
Show InChI InChI=1S/C27H35N5O3/c1-18-24(32(19-11-7-6-8-12-19)30-25(18)35-16-15-31(4)5)29-26(34)28-23-20-13-9-10-14-21(20)27(2,3)17-22(23)33/h6-14,22-23,33H,15-17H2,1-5H3,(H2,28,29,34)/t22-,23-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406191
PNG
(US10351575, Example 137 | US10351575, Example 138)
Show SMILES Cc1c(NC(=O)N[C@H]2[C@H](O)C3(CC3)c3ccccc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C26H26N6O2/c1-16-21(17-14-27-31(2)15-17)30-32(18-8-4-3-5-9-18)24(16)29-25(34)28-22-19-10-6-7-11-20(19)26(12-13-26)23(22)33/h3-11,14-15,22-23,33H,12-13H2,1-2H3,(H2,28,29,34)/t22-,23+/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406196
PNG
(US10351575, Example 142)
Show SMILES Cc1c(NC(=O)N[C@H]2[C@H](O)C3(CCC3)c3ccccc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C27H28N6O2/c1-17-22(18-15-28-32(2)16-18)31-33(19-9-4-3-5-10-19)25(17)30-26(35)29-23-20-11-6-7-12-21(20)27(24(23)34)13-8-14-27/h3-7,9-12,15-16,23-24,34H,8,13-14H2,1-2H3,(H2,29,30,35)/t23-,24+/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406206
PNG
(US10351575, Example 152)
Show SMILES COc1nn(c(NC(=O)N[C@H]2[C@H](O)CC3(CC3)c3ccccc23)c1C)-c1ccccc1
Show InChI InChI=1S/C24H26N4O3/c1-15-21(28(27-22(15)31-2)16-8-4-3-5-9-16)26-23(30)25-20-17-10-6-7-11-18(17)24(12-13-24)14-19(20)29/h3-11,19-20,29H,12-14H2,1-2H3,(H2,25,26,30)/t19-,20-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406217
PNG
(US10351575, Example 160)
Show SMILES Cc1c(NC(=O)N[C@H]2[C@H](O)C3(CCC3)Oc3ccccc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C27H28N6O3/c1-17-22(18-15-28-32(2)16-18)31-33(19-9-4-3-5-10-19)25(17)30-26(35)29-23-20-11-6-7-12-21(20)36-27(24(23)34)13-8-14-27/h3-7,9-12,15-16,23-24,34H,8,13-14H2,1-2H3,(H2,29,30,35)/t23-,24+/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406047
PNG
(US10351575, Example 1)
Show SMILES Cc1c(NC(=O)NC2CCCc3ccccc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C25H26N6O/c1-17-23(19-15-26-30(2)16-19)29-31(20-11-4-3-5-12-20)24(17)28-25(32)27-22-14-8-10-18-9-6-7-13-21(18)22/h3-7,9,11-13,15-16,22H,8,10,14H2,1-2H3,(H2,27,28,32)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406049
PNG
((S)-1-(2-phenyl-2,4,5,6- tetrahydrocyclopenta[c]py...)
Show SMILES O=C(N[C@H]1CCCc2ccccc12)Nc1c2CCCc2nn1-c1ccccc1
Show InChI InChI=1S/C23H24N4O/c28-23(24-20-14-6-9-16-8-4-5-12-18(16)20)25-22-19-13-7-15-21(19)26-27(22)17-10-2-1-3-11-17/h1-5,8,10-12,20H,6-7,9,13-15H2,(H2,24,25,28)/t20-/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406105
PNG
(US10351575, Example 58)
Show SMILES Cc1c(NC(=O)NC2[C@H](O)C3(CC3)c3cc(F)c(F)cc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C26H24F2N6O2/c1-14-21(15-12-29-33(2)13-15)32-34(16-6-4-3-5-7-16)24(14)31-25(36)30-22-17-10-19(27)20(28)11-18(17)26(8-9-26)23(22)35/h3-7,10-13,22-23,35H,8-9H2,1-2H3,(H2,30,31,36)/t22?,23-/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406146
PNG
(US10351575, Example 96)
Show SMILES COCc1ccc2C(C)N(CC(F)(F)F)CC(NC(=O)Nc3c(C)c(=O)[nH]n3-c3ccccc3)c2c1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406149
PNG
(US10351575, Example 99)
Show SMILES COC(=O)c1ccc2c(c1)C(NC(=O)Nc1c(C)c(C)nn1-c1ccccc1)[C@H](O)CC2(C)C
Show InChI InChI=1S/C26H30N4O4/c1-15-16(2)29-30(18-9-7-6-8-10-18)23(15)28-25(33)27-22-19-13-17(24(32)34-5)11-12-20(19)26(3,4)14-21(22)31/h6-13,21-22,31H,14H2,1-5H3,(H2,27,28,33)/t21-,22?/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406150
PNG
(US10351575, Example 100)
Show SMILES Cc1nn(c(NC(=O)NC2[C@H](O)CC(C)(C)c3ccc(CO)cc23)c1C)-c1ccccc1
Show InChI InChI=1S/C25H30N4O3/c1-15-16(2)28-29(18-8-6-5-7-9-18)23(15)27-24(32)26-22-19-12-17(14-30)10-11-20(19)25(3,4)13-21(22)31/h5-12,21-22,30-31H,13-14H2,1-4H3,(H2,26,27,32)/t21-,22?/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406198
PNG
(US10351575, Example 144)
Show SMILES COc1nn(c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c1C)-c1ccccc1
Show InChI InChI=1S/C24H28N4O3/c1-15-21(28(27-22(15)31-4)16-10-6-5-7-11-16)26-23(30)25-20-17-12-8-9-13-18(17)24(2,3)14-19(20)29/h5-13,19-20,29H,14H2,1-4H3,(H2,25,26,30)/t19-,20-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406057
PNG
(US10351575, Example 11)
Show SMILES Cc1nn(c(NC(=O)N[C@H]2CCCc3ccccc23)c1Br)-c1ccccc1
Show InChI InChI=1S/C21H21BrN4O/c1-14-19(22)20(26(25-14)16-10-3-2-4-11-16)24-21(27)23-18-13-7-9-15-8-5-6-12-17(15)18/h2-6,8,10-12,18H,7,9,13H2,1H3,(H2,23,24,27)/t18-/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406075
PNG
(N,4-dimethyl-1-phenyl-5- (3-(2-(2,2,2-trifluoroeth...)
Show SMILES CNC(=O)c1nn(c(NC(=O)NC2CN(CC(F)(F)F)Cc3ccccc23)c1C)-c1ccccc1
Show InChI InChI=1S/C24H25F3N6O2/c1-15-20(22(34)28-2)31-33(17-9-4-3-5-10-17)21(15)30-23(35)29-19-13-32(14-24(25,26)27)12-16-8-6-7-11-18(16)19/h3-11,19H,12-14H2,1-2H3,(H,28,34)(H2,29,30,35)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406113
PNG
(US10351575, Example 65)
Show SMILES Cc1c(NC(=O)N[C@H]2[C@H](O)Cc3ccccc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C24H24N6O2/c1-15-21(17-13-25-29(2)14-17)28-30(18-9-4-3-5-10-18)23(15)27-24(32)26-22-19-11-7-6-8-16(19)12-20(22)31/h3-11,13-14,20,22,31H,12H2,1-2H3,(H2,26,27,32)/t20-,22-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406114
PNG
(US10351575, Example 66)
Show SMILES Cc1c(NC(=O)N[C@H]2[C@H](O)Cc3ccccc23)n(nc1-c1cnc(C)nc1)-c1ccccc1
Show InChI InChI=1S/C25H24N6O2/c1-15-22(18-13-26-16(2)27-14-18)30-31(19-9-4-3-5-10-19)24(15)29-25(33)28-23-20-11-7-6-8-17(20)12-21(23)32/h3-11,13-14,21,23,32H,12H2,1-2H3,(H2,28,29,33)/t21-,23-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406129
PNG
(US10351575, Example 81)
Show SMILES CN1CCC(COc2nn(c(NC(=O)N[C@H]3[C@H](O)CC(C)(C)c4cc(F)c(F)cc34)c2C)-c2ccccc2)CC1
Show InChI InChI=1S/C30H37F2N5O3/c1-18-27(34-29(39)33-26-21-14-23(31)24(32)15-22(21)30(2,3)16-25(26)38)37(20-8-6-5-7-9-20)35-28(18)40-17-19-10-12-36(4)13-11-19/h5-9,14-15,19,25-26,38H,10-13,16-17H2,1-4H3,(H2,33,34,39)/t25-,26-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406138
PNG
(US10351575, Example 89)
Show SMILES Cc1c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)ccc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C27H29FN6O2/c1-16-23(17-14-29-33(4)15-17)32-34(19-8-6-5-7-9-19)25(16)31-26(36)30-24-20-11-10-18(28)12-21(20)27(2,3)13-22(24)35/h5-12,14-15,22,24,35H,13H2,1-4H3,(H2,30,31,36)/t22-,24-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406139
PNG
(US10351575, Example 90)
Show SMILES Cc1c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)ccc23)n(nc1-c1ccc(=O)n(C)c1)-c1ccccc1
Show InChI InChI=1S/C29H30FN5O3/c1-17-25(18-10-13-24(37)34(4)16-18)33-35(20-8-6-5-7-9-20)27(17)32-28(38)31-26-21-12-11-19(30)14-22(21)29(2,3)15-23(26)36/h5-14,16,23,26,36H,15H2,1-4H3,(H2,31,32,38)/t23-,26-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406143
PNG
(US10351575, Example 148 | US10351575, Example 94)
Show SMILES Cc1c(CCO)nn(c1NC(=O)N[C@H]1[C@H](O)CC(C)(C)c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C25H30N4O3/c1-16-20(13-14-30)28-29(17-9-5-4-6-10-17)23(16)27-24(32)26-22-18-11-7-8-12-19(18)25(2,3)15-21(22)31/h4-12,21-22,30-31H,13-15H2,1-3H3,(H2,26,27,32)/t21-,22-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406153
PNG
((S)-1-(1',4-dimethyl-1- phenyl-1H,1'H-[3,4'- bipyr...)
Show SMILES Cc1c(NC(=O)N[C@H]2CCCc3cc(F)ccc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C25H25FN6O/c1-16-23(18-14-27-31(2)15-18)30-32(20-8-4-3-5-9-20)24(16)29-25(33)28-22-10-6-7-17-13-19(26)11-12-21(17)22/h3-5,8-9,11-15,22H,6-7,10H2,1-2H3,(H2,28,29,33)/t22-/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406159
PNG
(1-(trans-2-hydroxy-4,4- dimethyl-1,2,3,4- tetrahyd...)
Show SMILES Cc1c(NC(=O)NC2[C@H](O)CC(C)(C)c3ccccc23)n(nc1-c1ccn(C)c(=O)c1)-c1ccccc1
Show InChI InChI=1S/C29H31N5O3/c1-18-25(19-14-15-33(4)24(36)16-19)32-34(20-10-6-5-7-11-20)27(18)31-28(37)30-26-21-12-8-9-13-22(21)29(2,3)17-23(26)35/h5-16,23,26,35H,17H2,1-4H3,(H2,30,31,37)/t23-,26?/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406160
PNG
(1-(trans-2-hydroxy-4,4- dimethyl-1,2,3,4- tetrahyd...)
Show SMILES CC1(C)C[C@@H](O)C(NC(=O)Nc2c3COCc3nn2-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C24H26N4O3/c1-24(2)12-20(29)21(16-10-6-7-11-18(16)24)25-23(30)26-22-17-13-31-14-19(17)27-28(22)15-8-4-3-5-9-15/h3-11,20-21,29H,12-14H2,1-2H3,(H2,25,26,30)/t20-,21?/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406162
PNG
(5-(3-(6-(methoxymethyl)- 1-methyl-2-(2,2,2- triflu...)
Show SMILES COCc1ccc2C(C)N(CC(F)(F)F)CC(NC(=O)Nc3c(C)c(nn3-c3ccccc3)C(N)=O)c2c1
Show InChI InChI=1S/C26H29F3N6O3/c1-15-22(23(30)36)33-35(18-7-5-4-6-8-18)24(15)32-25(37)31-21-12-34(14-26(27,28)29)16(2)19-10-9-17(13-38-3)11-20(19)21/h4-11,16,21H,12-14H2,1-3H3,(H2,30,36)(H2,31,32,37)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406169
PNG
(US10351575, Example 117)
Show SMILES Cc1c(NC(=O)NC2[C@H](O)CC(C)(C)c3ccccc23)n(nc1-c1cnc(C)nc1)-c1ccccc1
Show InChI InChI=1S/C28H30N6O2/c1-17-24(19-15-29-18(2)30-16-19)33-34(20-10-6-5-7-11-20)26(17)32-27(36)31-25-21-12-8-9-13-22(21)28(3,4)14-23(25)35/h5-13,15-16,23,25,35H,14H2,1-4H3,(H2,31,32,36)/t23-,25?/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406184
PNG
(1-(4-methyl-3-(2- methylpyrimidin-5-yl)-1- phenyl-...)
Show SMILES Cc1c(NC(=O)NC2CN(CC(F)(F)F)C(=O)c3ccccc23)n(nc1-c1cnc(C)nc1)-c1ccccc1
Show InChI InChI=1S/C27H24F3N7O2/c1-16-23(18-12-31-17(2)32-13-18)35-37(19-8-4-3-5-9-19)24(16)34-26(39)33-22-14-36(15-27(28,29)30)25(38)21-11-7-6-10-20(21)22/h3-13,22H,14-15H2,1-2H3,(H2,33,34,39)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406187
PNG
(US10351575, Example 133)
Show SMILES Cc1c(OCCN2CCOCC2)nn(c1NC(=O)N[C@H]1[C@H](O)CC(C)(C)c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C29H37N5O4/c1-20-26(31-28(36)30-25-22-11-7-8-12-23(22)29(2,3)19-24(25)35)34(21-9-5-4-6-10-21)32-27(20)38-18-15-33-13-16-37-17-14-33/h4-12,24-25,35H,13-19H2,1-3H3,(H2,30,31,36)/t24-,25-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406194
PNG
(US10351575, Example 140)
Show SMILES O[C@H]1[C@H](NC(=O)Nc2c(Cl)c(OC[C@H]3CNCCO3)nn2-c2ccccc2)c2ccccc2C11CC1
Show InChI InChI=1S/C26H28ClN5O4/c27-20-23(30-25(34)29-21-18-8-4-5-9-19(18)26(10-11-26)22(21)33)32(16-6-2-1-3-7-16)31-24(20)36-15-17-14-28-12-13-35-17/h1-9,17,21-22,28,33H,10-15H2,(H2,29,30,34)/t17-,21-,22+/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406203
PNG
(US10351575, Example 149)
Show SMILES Cc1c(OCCO)nn(c1NC(=O)N[C@H]1[C@H](O)CC(C)(C)c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C25H30N4O4/c1-16-22(29(17-9-5-4-6-10-17)28-23(16)33-14-13-30)27-24(32)26-21-18-11-7-8-12-19(18)25(2,3)15-20(21)31/h4-12,20-21,30-31H,13-15H2,1-3H3,(H2,26,27,32)/t20-,21-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406204
PNG
(US10351575, Example 150)
Show SMILES Cc1c(OC[C@H]2CNCCO2)nn(c1NC(=O)N[C@H]1[C@H](O)CC(C)(C)c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C28H35N5O4/c1-18-25(31-27(35)30-24-21-11-7-8-12-22(21)28(2,3)15-23(24)34)33(19-9-5-4-6-10-19)32-26(18)37-17-20-16-29-13-14-36-20/h4-12,20,23-24,29,34H,13-17H2,1-3H3,(H2,30,31,35)/t20-,23-,24-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406209
PNG
(1-((r-1,t-2,t-3)-2-hydroxy- 3-methoxy-4,4-dimethyl...)
Show SMILES CO[C@H]1[C@@H](O)[C@H](NC(=O)Nc2c(C)c(OC)nn2-c2ccccc2)c2ccccc2C1(C)C
Show InChI InChI=1S/C25H30N4O4/c1-15-22(29(28-23(15)33-5)16-11-7-6-8-12-16)27-24(31)26-19-17-13-9-10-14-18(17)25(2,3)21(32-4)20(19)30/h6-14,19-21,30H,1-5H3,(H2,26,27,31)/t19-,20+,21+/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406212
PNG
(1-((r-1,t-2,t-3)-2-hydroxy- 3-methoxy-4,4-dimethyl...)
Show SMILES CO[C@H]1[C@@H](O)[C@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnc(C)nc2)c2ccccc2C1(C)C
Show InChI InChI=1S/C29H32N6O3/c1-17-23(19-15-30-18(2)31-16-19)34-35(20-11-7-6-8-12-20)27(17)33-28(37)32-24-21-13-9-10-14-22(21)29(3,4)26(38-5)25(24)36/h6-16,24-26,36H,1-5H3,(H2,32,33,37)/t24-,25+,26+/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406073
PNG
(1-(4-methyl-3-(1-methyl- 1H-imidazol-4-yl)-1- phen...)
Show SMILES Cc1c(NC(=O)NC2CN(CC(F)(F)F)Cc3ccccc23)n(nc1-c1cn(C)cn1)-c1ccccc1
Show InChI InChI=1S/C26H26F3N7O/c1-17-23(22-13-34(2)16-30-22)33-36(19-9-4-3-5-10-19)24(17)32-25(37)31-21-14-35(15-26(27,28)29)12-18-8-6-7-11-20(18)21/h3-11,13,16,21H,12,14-15H2,1-2H3,(H2,31,32,37)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406080
PNG
(US10351575, Example 34)
Show SMILES Cc1c(NC(=O)NC2CC3(CCC3)Oc3ccc(Br)cc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C27H27BrN6O2/c1-17-24(18-15-29-33(2)16-18)32-34(20-7-4-3-5-8-20)25(17)31-26(35)30-22-14-27(11-6-12-27)36-23-10-9-19(28)13-21(22)23/h3-5,7-10,13,15-16,22H,6,11-12,14H2,1-2H3,(H2,30,31,35)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406088
PNG
(US10351575, Example 41)
Show SMILES CN1CCC(NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2ccc(=O)n(C)c2)c2ccccc12
Show InChI InChI=1S/C27H28N6O2/c1-18-25(19-13-14-24(34)32(3)17-19)30-33(20-9-5-4-6-10-20)26(18)29-27(35)28-22-15-16-31(2)23-12-8-7-11-21(22)23/h4-14,17,22H,15-16H2,1-3H3,(H2,28,29,35)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406115
PNG
(US10351575, Example 67)
Show SMILES CCOc1ncc(cn1)-c1nn(c(NC(=O)N[C@H]2[C@H](O)Cc3ccccc23)c1C)-c1ccccc1
Show InChI InChI=1S/C26H26N6O3/c1-3-35-26-27-14-18(15-28-26)22-16(2)24(32(31-22)19-10-5-4-6-11-19)30-25(34)29-23-20-12-8-7-9-17(20)13-21(23)33/h4-12,14-15,21,23,33H,3,13H2,1-2H3,(H2,29,30,34)/t21-,23-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406116
PNG
(US10351575, Example 68)
Show SMILES COc1ncc(cn1)-c1nn(c(NC(=O)N[C@H]2[C@H](O)Cc3ccccc23)c1C)-c1ccccc1
Show InChI InChI=1S/C25H24N6O3/c1-15-21(17-13-26-25(34-2)27-14-17)30-31(18-9-4-3-5-10-18)23(15)29-24(33)28-22-19-11-7-6-8-16(19)12-20(22)32/h3-11,13-14,20,22,32H,12H2,1-2H3,(H2,28,29,33)/t20-,22-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406136
PNG
(US10351575, Example 87)
Show SMILES CO[C@H]1[C@@H](O)[C@H](NC(=O)Nc2c(C)c(OCC3CCN(C)CC3)nn2-c2ccccc2)c2ccccc2C1(C)C
Show InChI InChI=1S/C31H41N5O4/c1-20-28(33-30(38)32-25-23-13-9-10-14-24(23)31(2,3)27(39-5)26(25)37)36(22-11-7-6-8-12-22)34-29(20)40-19-21-15-17-35(4)18-16-21/h6-14,21,25-27,37H,15-19H2,1-5H3,(H2,32,33,38)/t25-,26+,27+/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406167
PNG
(1-(6-bromo-2,2- dioxidoisothiochroman-4- yl)-3-(1'...)
Show SMILES Cc1c(NC(=O)NC2CS(=O)(=O)Cc3ccc(Br)cc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C24H23BrN6O3S/c1-15-22(17-11-26-30(2)12-17)29-31(19-6-4-3-5-7-19)23(15)28-24(32)27-21-14-35(33,34)13-16-8-9-18(25)10-20(16)21/h3-12,21H,13-14H2,1-2H3,(H2,27,28,32)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406177
PNG
(1-(trans-2-hydroxy- 1,2,3,4- tetrahydronaphthalen-...)
Show SMILES CN1CCC(COc2nn(c(NC(=O)NC3[C@H](O)CCc4ccccc34)c2C)-c2ccccc2)CC1
Show InChI InChI=1S/C28H35N5O3/c1-19-26(30-28(35)29-25-23-11-7-6-8-21(23)12-13-24(25)34)33(22-9-4-3-5-10-22)31-27(19)36-18-20-14-16-32(2)17-15-20/h3-11,20,24-25,34H,12-18H2,1-2H3,(H2,29,30,35)/t24-,25?/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406185
PNG
(1-(3,4-dimethyl-1- phenyl-1H-pyrazol-5-yl)- 3-(1-o...)
Show SMILES Cc1nn(c(NC(=O)NC2CN(CC(F)(F)F)C(=O)c3ccccc23)c1C)-c1ccccc1
Show InChI InChI=1S/C23H22F3N5O2/c1-14-15(2)29-31(16-8-4-3-5-9-16)20(14)28-22(33)27-19-12-30(13-23(24,25)26)21(32)18-11-7-6-10-17(18)19/h3-11,19H,12-13H2,1-2H3,(H2,27,28,33)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406193
PNG
(US10351575, Example 139)
Show SMILES CC(C)(C)OC(=O)N1CCO[C@@H](COc2nn(c(NC(=O)N[C@H]3[C@H](O)C4(CC4)c4ccccc34)c2Cl)-c2ccccc2)C1
Show InChI InChI=1S/C31H36ClN5O6/c1-30(2,3)43-29(40)36-15-16-41-20(17-36)18-42-27-23(32)26(37(35-27)19-9-5-4-6-10-19)34-28(39)33-24-21-11-7-8-12-22(21)31(13-14-31)25(24)38/h4-12,20,24-25,38H,13-18H2,1-3H3,(H2,33,34,39)/t20-,24-,25+/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406215
PNG
(1-((r-1,t-2,c-3)-2- hydroxy-3-methoxy- 4,4-dimethy...)
Show SMILES CO[C@@H]1[C@@H](O)[C@H](NC(=O)Nc2c(C)c(OCC3CCN(C)CC3)nn2-c2ccccc2)c2ccccc2C1(C)C
Show InChI InChI=1S/C31H41N5O4/c1-20-28(33-30(38)32-25-23-13-9-10-14-24(23)31(2,3)27(39-5)26(25)37)36(22-11-7-6-8-12-22)34-29(20)40-19-21-15-17-35(4)18-16-21/h6-14,21,25-27,37H,15-19H2,1-5H3,(H2,32,33,38)/t25-,26+,27-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406216
PNG
(US10351575, Example 159)
Show SMILES COc1nn(c(NC(=O)N[C@H]2[C@H](O)C3(CCC3)Oc3ccccc23)c1C)-c1ccccc1
Show InChI InChI=1S/C24H26N4O4/c1-15-21(28(27-22(15)31-2)16-9-4-3-5-10-16)26-23(30)25-19-17-11-6-7-12-18(17)32-24(20(19)29)13-8-14-24/h3-7,9-12,19-20,29H,8,13-14H2,1-2H3,(H2,25,26,30)/t19-,20+/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406071
PNG
(US10351575, Example 25)
Show SMILES Cc1c(NC(=O)NC2CN(CC(F)(F)F)Cc3ccccc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C26H26F3N7O/c1-17-23(19-12-30-34(2)13-19)33-36(20-9-4-3-5-10-20)24(17)32-25(37)31-22-15-35(16-26(27,28)29)14-18-8-6-7-11-21(18)22/h3-13,22H,14-16H2,1-2H3,(H2,31,32,37)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406078
PNG
(US10351575, Example 32)
Show SMILES COCc1ccc2COCC(NC(=O)Nc3c(C)c(nn3-c3ccccc3)-c3cnn(C)c3)c2c1
Show InChI InChI=1S/C26H28N6O3/c1-17-24(20-12-27-31(2)13-20)30-32(21-7-5-4-6-8-21)25(17)29-26(33)28-23-16-35-15-19-10-9-18(14-34-3)11-22(19)23/h4-13,23H,14-16H2,1-3H3,(H2,28,29,33)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406079
PNG
(US10351575, Example 33)
Show SMILES Cc1c(NC(=O)NC2CC(Oc3ccc(Br)cc23)C2CC2)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C27H27BrN6O2/c1-16-25(18-14-29-33(2)15-18)32-34(20-6-4-3-5-7-20)26(16)31-27(35)30-22-13-24(17-8-9-17)36-23-11-10-19(28)12-21(22)23/h3-7,10-12,14-15,17,22,24H,8-9,13H2,1-2H3,(H2,30,31,35)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406092
PNG
(US10351575, Example 45)
Show SMILES CCN1CCC(NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2ccc(=O)n(C)c2)c2cc(Cl)ccc12
Show InChI InChI=1S/C28H29ClN6O2/c1-4-34-15-14-23(22-16-20(29)11-12-24(22)34)30-28(37)31-27-18(2)26(19-10-13-25(36)33(3)17-19)32-35(27)21-8-6-5-7-9-21/h5-13,16-17,23H,4,14-15H2,1-3H3,(H2,30,31,37)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406125
PNG
(US10351575, Example 77)
Show SMILES CN1CCO[C@@H](COc2nn(c(NC(=O)NC3[C@H](O)CC(C)(C)c4cc(F)c(F)cc34)c2C)-c2ccccc2)C1
Show InChI InChI=1S/C29H35F2N5O4/c1-17-26(33-28(38)32-25-20-12-22(30)23(31)13-21(20)29(2,3)14-24(25)37)36(18-8-6-5-7-9-18)34-27(17)40-16-19-15-35(4)10-11-39-19/h5-9,12-13,19,24-25,37H,10-11,14-16H2,1-4H3,(H2,32,33,38)/t19-,24-,25?/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406141
PNG
(US10351575, Example 92)
Show SMILES Cc1c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccc(F)cc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C27H29FN6O2/c1-16-23(17-14-29-33(4)15-17)32-34(19-8-6-5-7-9-19)25(16)31-26(36)30-24-20-12-18(28)10-11-21(20)27(2,3)13-22(24)35/h5-12,14-15,22,24,35H,13H2,1-4H3,(H2,30,31,36)/t22-,24-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406145
PNG
(US10351575, Example 95)
Show SMILES Cc1c(NC(=O)NC2[C@H](O)CC(C)(C)c3ccccc23)n([nH]c1=O)-c1ccccc1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406151
PNG
(1-(1',4-dimethyl-1- phenyl-1H,1'H-[3,4'- bipyrazol...)
Show SMILES Cc1c(NC(=O)NC2[C@H](O)CCc3ccccc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C25H26N6O2/c1-16-22(18-14-26-30(2)15-18)29-31(19-9-4-3-5-10-19)24(16)28-25(33)27-23-20-11-7-6-8-17(20)12-13-21(23)32/h3-11,14-15,21,23,32H,12-13H2,1-2H3,(H2,27,28,33)/t21-,23?/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406152
PNG
(1-(1',4-dimethyl-1- phenyl-1H,1'H-[3,4'- bipyrazol...)
Show SMILES COCc1ccc2c(c1)C(NC(=O)Nc1c(C)c(nn1-c1ccccc1)-c1cnn(C)c1)[C@H](O)CC2(C)C
Show InChI InChI=1S/C29H34N6O3/c1-18-25(20-15-30-34(4)16-20)33-35(21-9-7-6-8-10-21)27(18)32-28(37)31-26-22-13-19(17-38-5)11-12-23(22)29(2,3)14-24(26)36/h6-13,15-16,24,26,36H,14,17H2,1-5H3,(H2,31,32,37)/t24-,26?/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406156
PNG
(1-(trans-7-chloro-2- hydroxy-4,4-dimethyl- 1,2,3,4...)
Show SMILES Cc1c(NC(=O)NC2[C@H](O)CC(C)(C)c3ccc(Cl)cc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C27H29ClN6O2/c1-16-23(17-14-29-33(4)15-17)32-34(19-8-6-5-7-9-19)25(16)31-26(36)30-24-20-12-18(28)10-11-21(20)27(2,3)13-22(24)35/h5-12,14-15,22,24,35H,13H2,1-4H3,(H2,30,31,36)/t22-,24?/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406164
PNG
(1-(6-bromothiochroman- 4-yl)-3-(1',4-dimethyl-1- p...)
Show SMILES Cc1c(NC(=O)NC2CCSc3ccc(Br)cc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C24H23BrN6OS/c1-15-22(16-13-26-30(2)14-16)29-31(18-6-4-3-5-7-18)23(15)28-24(32)27-20-10-11-33-21-9-8-17(25)12-19(20)21/h3-9,12-14,20H,10-11H2,1-2H3,(H2,27,28,32)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406173
PNG
(5-(3-(trans-2-hydroxy-7- (methoxymethyl)-4,4- dime...)
Show SMILES CNC(=O)c1nn(c(NC(=O)NC2[C@H](O)CC(C)(C)c3ccc(COC)cc23)c1C)-c1ccccc1
Show InChI InChI=1S/C27H33N5O4/c1-16-22(25(34)28-4)31-32(18-9-7-6-8-10-18)24(16)30-26(35)29-23-19-13-17(15-36-5)11-12-20(19)27(2,3)14-21(23)33/h6-13,21,23,33H,14-15H2,1-5H3,(H,28,34)(H2,29,30,35)/t21-,23?/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406179
PNG
(5-(3-(trans-7-chloro-2- hydroxy-4,4-dimethyl- 1,2,...)
Show SMILES CNC(=O)c1nn(c(NC(=O)NC2[C@H](O)CC(C)(C)c3ccc(Cl)cc23)c1C)-c1ccccc1
Show InChI InChI=1S/C25H28ClN5O3/c1-14-20(23(33)27-4)30-31(16-8-6-5-7-9-16)22(14)29-24(34)28-21-17-12-15(26)10-11-18(17)25(2,3)13-19(21)32/h5-12,19,21,32H,13H2,1-4H3,(H,27,33)(H2,28,29,34)/t19-,21?/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406197
PNG
(US10351575, Example 143)
Show SMILES Cc1c(OC[C@H]2CN(CCO2)C(=O)OC(C)(C)C)nn(c1NC(=O)NC1[C@H](O)CC(C)(C)c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C33H43N5O6/c1-21-28(35-30(40)34-27-24-14-10-11-15-25(24)33(5,6)18-26(27)39)38(22-12-8-7-9-13-22)36-29(21)43-20-23-19-37(16-17-42-23)31(41)44-32(2,3)4/h7-15,23,26-27,39H,16-20H2,1-6H3,(H2,34,35,40)/t23-,26-,27?/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406056
PNG
(1-(6-bromoisochroman-4-yl)-3- (1',4-dimethyl-1-phe...)
Show SMILES Cc1c(NC(=O)NC2COCc3ccc(Br)cc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C24H23BrN6O2/c1-15-22(17-11-26-30(2)12-17)29-31(19-6-4-3-5-7-19)23(15)28-24(32)27-21-14-33-13-16-8-9-18(25)10-20(16)21/h3-12,21H,13-14H2,1-2H3,(H2,27,28,32)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406061
PNG
(1-(7-bromo-1,2,3,4- tetrahydronaphthalen-1-yl)-3- ...)
Show SMILES Cc1c(NC(=O)NC2CCCc3ccc(Br)cc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C25H25BrN6O/c1-16-23(18-14-27-31(2)15-18)30-32(20-8-4-3-5-9-20)24(16)29-25(33)28-22-10-6-7-17-11-12-19(26)13-21(17)22/h3-5,8-9,11-15,22H,6-7,10H2,1-2H3,(H2,28,29,33)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406072
PNG
(1-(4-methyl-3-(1-methyl-6- oxo-1,6-dihydropyridin-...)
Show SMILES Cc1c(NC(=O)NC2CN(CC(F)(F)F)Cc3ccccc23)n(nc1-c1ccc(=O)n(C)c1)-c1ccccc1
Show InChI InChI=1S/C28H27F3N6O2/c1-18-25(20-12-13-24(38)35(2)14-20)34-37(21-9-4-3-5-10-21)26(18)33-27(39)32-23-16-36(17-28(29,30)31)15-19-8-6-7-11-22(19)23/h3-14,23H,15-17H2,1-2H3,(H2,32,33,39)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406074
PNG
(1-(2-phenyl-2,4,5,6- tetrahydrocyclopenta[c] pyraz...)
Show SMILES FC(F)(F)CN1CC(NC(=O)Nc2c3CCCc3nn2-c2ccccc2)c2ccccc2C1
Show InChI InChI=1S/C24H24F3N5O/c25-24(26,27)15-31-13-16-7-4-5-10-18(16)21(14-31)28-23(33)29-22-19-11-6-12-20(19)30-32(22)17-8-2-1-3-9-17/h1-5,7-10,21H,6,11-15H2,(H2,28,29,33)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406093
PNG
(US10351575, Example 46)
Show SMILES CCN1CCC(NC(=O)Nc2c(C)c(OC)nn2-c2ccccc2)c2cc(Cl)ccc12
Show InChI InChI=1S/C23H26ClN5O2/c1-4-28-13-12-19(18-14-16(24)10-11-20(18)28)25-23(30)26-21-15(2)22(31-3)27-29(21)17-8-6-5-7-9-17/h5-11,14,19H,4,12-13H2,1-3H3,(H2,25,26,30)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406110
PNG
(1-(trans-5',6'-difluoro-2'- hydroxy-2',3'- dihydro...)
Show SMILES COc1nn(c(NC(=O)NC2[C@H](O)C3(CC3)c3cc(F)c(F)cc23)c1C)-c1ccccc1
Show InChI InChI=1S/C23H22F2N4O3/c1-12-20(29(28-21(12)32-2)13-6-4-3-5-7-13)27-22(31)26-18-14-10-16(24)17(25)11-15(14)23(8-9-23)19(18)30/h3-7,10-11,18-19,30H,8-9H2,1-2H3,(H2,26,27,31)/t18?,19-/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406117
PNG
(US10351575, Example 69)
Show SMILES Cc1c(NC(=O)N[C@H]2[C@H](O)Cc3ccccc23)n(nc1-c1cc(C)c(=O)n(C)c1)-c1ccccc1
Show InChI InChI=1S/C27H27N5O3/c1-16-13-19(15-31(3)26(16)34)23-17(2)25(32(30-23)20-10-5-4-6-11-20)29-27(35)28-24-21-12-8-7-9-18(21)14-22(24)33/h4-13,15,22,24,33H,14H2,1-3H3,(H2,28,29,35)/t22-,24-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406122
PNG
(US10351575, Example 74)
Show SMILES CN1CCO[C@@H](COc2nn(c(NC(=O)N[C@H]3[C@H](O)CC(C)(C)c4ccccc34)c2C)-c2ccccc2)C1
Show InChI InChI=1S/C29H37N5O4/c1-19-26(31-28(36)30-25-22-12-8-9-13-23(22)29(2,3)16-24(25)35)34(20-10-6-5-7-11-20)32-27(19)38-18-21-17-33(4)14-15-37-21/h5-13,21,24-25,35H,14-18H2,1-4H3,(H2,30,31,36)/t21-,24-,25-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406127
PNG
(US10351575, Example 79)
Show SMILES CNC(=O)c1nn(c(NC(=O)NC2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c1C)-c1ccccc1
Show InChI InChI=1S/C25H27F2N5O3/c1-13-20(23(34)28-4)31-32(14-8-6-5-7-9-14)22(13)30-24(35)29-21-15-10-17(26)18(27)11-16(15)25(2,3)12-19(21)33/h5-11,19,21,33H,12H2,1-4H3,(H,28,34)(H2,29,30,35)/t19-,21?/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406132
PNG
(US10351575, Example 83)
Show SMILES Cc1c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)n(nc1-c1ccc(=O)n(C)c1)-c1ccccc1
Show InChI InChI=1S/C29H29F2N5O3/c1-16-25(17-10-11-24(38)35(4)15-17)34-36(18-8-6-5-7-9-18)27(16)33-28(39)32-26-19-12-21(30)22(31)13-20(19)29(2,3)14-23(26)37/h5-13,15,23,26,37H,14H2,1-4H3,(H2,32,33,39)/t23-,26-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406134
PNG
(US10351575, Example 85)
Show SMILES CNC(=O)c1nn(c(NC(=O)N[C@H]2[C@H](O)[C@H](OC)C(C)(C)c3ccccc23)c1C)-c1ccccc1
Show InChI InChI=1S/C26H31N5O4/c1-15-19(24(33)27-4)30-31(16-11-7-6-8-12-16)23(15)29-25(34)28-20-17-13-9-10-14-18(17)26(2,3)22(35-5)21(20)32/h6-14,20-22,32H,1-5H3,(H,27,33)(H2,28,29,34)/t20-,21+,22+/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406140
PNG
(US10351575, Example 91)
Show SMILES CNC(=O)c1nn(c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccc(F)cc23)c1C)-c1ccccc1
Show InChI InChI=1S/C25H28FN5O3/c1-14-20(23(33)27-4)30-31(16-8-6-5-7-9-16)22(14)29-24(34)28-21-17-12-15(26)10-11-18(17)25(2,3)13-19(21)32/h5-12,19,21,32H,13H2,1-4H3,(H,27,33)(H2,28,29,34)/t19-,21-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406158
PNG
(1-(trans-2-hydroxy-4,4- dimethyl-1,2,3,4- tetrahyd...)
Show SMILES Cc1c(NC(=O)NC2[C@H](O)CC(C)(C)c3ccccc23)n(nc1-c1ccc(=O)n(C)c1)-c1ccccc1
Show InChI InChI=1S/C29H31N5O3/c1-18-25(19-14-15-24(36)33(4)17-19)32-34(20-10-6-5-7-11-20)27(18)31-28(37)30-26-21-12-8-9-13-22(21)29(2,3)16-23(26)35/h5-15,17,23,26,35H,16H2,1-4H3,(H2,30,31,37)/t23-,26?/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406174
PNG
(1-(3,4-dimethyl-1- phenyl-1H-pyrazol-5-yl)- 3-(tra...)
Show SMILES Cc1nn(c(NC(=O)NC2[C@H](O)CCc3ccccc23)c1C)-c1ccccc1
Show InChI InChI=1S/C22H24N4O2/c1-14-15(2)25-26(17-9-4-3-5-10-17)21(14)24-22(28)23-20-18-11-7-6-8-16(18)12-13-19(20)27/h3-11,19-20,27H,12-13H2,1-2H3,(H2,23,24,28)/t19-,20?/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406176
PNG
(1-(trans-2-hydroxy-4,4- dimethyl-1,2,3,4- tetrahyd...)
Show SMILES CN1CCC(COc2nn(c(NC(=O)NC3[C@H](O)CC(C)(C)c4ccccc34)c2C)-c2ccccc2)CC1
Show InChI InChI=1S/C30H39N5O3/c1-20-27(32-29(37)31-26-23-12-8-9-13-24(23)30(2,3)18-25(26)36)35(22-10-6-5-7-11-22)33-28(20)38-19-21-14-16-34(4)17-15-21/h5-13,21,25-26,36H,14-19H2,1-4H3,(H2,31,32,37)/t25-,26?/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406201
PNG
(1-((1R,2R)-2-hydroxy-4,4- dimethyl-1,2,3,4- tetrah...)
Show SMILES COCCOc1nn(c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c1C)-c1ccccc1
Show InChI InChI=1S/C26H32N4O4/c1-17-23(30(18-10-6-5-7-11-18)29-24(17)34-15-14-33-4)28-25(32)27-22-19-12-8-9-13-20(19)26(2,3)16-21(22)31/h5-13,21-22,31H,14-16H2,1-4H3,(H2,27,28,32)/t21-,22-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406143
PNG
(US10351575, Example 148 | US10351575, Example 94)
Show SMILES Cc1c(CCO)nn(c1NC(=O)N[C@H]1[C@H](O)CC(C)(C)c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C25H30N4O3/c1-16-20(13-14-30)28-29(17-9-5-4-6-10-17)23(16)27-24(32)26-22-18-11-7-8-12-19(18)25(2,3)15-21(22)31/h4-12,21-22,30-31H,13-15H2,1-3H3,(H2,26,27,32)/t21-,22-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406048
PNG
((S)-1-(1',4-dimethyl-1-phenyl- 1H,1'H-3,4'-bipyraz...)
Show SMILES Cc1c(NC(=O)N[C@H]2CCCc3ccccc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C25H26N6O/c1-17-23(19-15-26-30(2)16-19)29-31(20-11-4-3-5-12-20)24(17)28-25(32)27-22-14-8-10-18-9-6-7-13-21(18)22/h3-7,9,11-13,15-16,22H,8,10,14H2,1-2H3,(H2,27,28,32)/t22-/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406052
PNG
(1-(1',4-dimethyl-1-phenyl- 1H,1'H-3,4'-bipyrazol-5...)
Show SMILES Cc1c(NC(=O)NC2CCCCc3ccccc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C26H28N6O/c1-18-24(20-16-27-31(2)17-20)30-32(21-12-4-3-5-13-21)25(18)29-26(33)28-23-15-9-7-11-19-10-6-8-14-22(19)23/h3-6,8,10,12-14,16-17,23H,7,9,11,15H2,1-2H3,(H2,28,29,33)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406076
PNG
(US10351575, Example 30)
Show SMILES Cc1c(NC(=O)NC2CN(CC(F)(F)F)Cc3ccccc23)n([nH]c1=O)-c1ccccc1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406086
PNG
(US10351575, Example 39)
Show SMILES COc1nn(c(NC(=O)NC2CCN(C)c3ccccc23)c1C)-c1ccccc1
Show InChI InChI=1S/C22H25N5O2/c1-15-20(27(25-21(15)29-3)16-9-5-4-6-10-16)24-22(28)23-18-13-14-26(2)19-12-8-7-11-17(18)19/h4-12,18H,13-14H2,1-3H3,(H2,23,24,28)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406089
PNG
(US10351575, Example 42)
Show SMILES CCN1CCC(NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2ccc(=O)n(C)c2)c2ccccc12
Show InChI InChI=1S/C28H30N6O2/c1-4-33-17-16-23(22-12-8-9-13-24(22)33)29-28(36)30-27-19(2)26(20-14-15-25(35)32(3)18-20)31-34(27)21-10-6-5-7-11-21/h5-15,18,23H,4,16-17H2,1-3H3,(H2,29,30,36)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406104
PNG
(US10351575, Example 57)
Show SMILES COc1ncc(cn1)-c1nn(c(NC(=O)NC2[C@H](O)C3(CC3)c3ccccc23)c1C)-c1ccccc1
Show InChI InChI=1S/C27H26N6O3/c1-16-21(17-14-28-26(36-2)29-15-17)32-33(18-8-4-3-5-9-18)24(16)31-25(35)30-22-19-10-6-7-11-20(19)27(12-13-27)23(22)34/h3-11,14-15,22-23,34H,12-13H2,1-2H3,(H2,30,31,35)/t22?,23-/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406109
PNG
(1-(3-ethoxy-4-methyl-1- phenyl-1H-pyrazol-5-yl)-3-...)
Show SMILES CCOc1nn(c(NC(=O)NC2[C@H](O)C3(CC3)c3ccccc23)c1C)-c1ccccc1
Show InChI InChI=1S/C24H26N4O3/c1-3-31-22-15(2)21(28(27-22)16-9-5-4-6-10-16)26-23(30)25-19-17-11-7-8-12-18(17)24(13-14-24)20(19)29/h4-12,19-20,29H,3,13-14H2,1-2H3,(H2,25,26,30)/t19?,20-/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406112
PNG
(US10351575, Example 64)
Show SMILES Cc1c(NC(=O)NC2[C@H](O)C3(CC3)c3cc(F)ccc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C26H25FN6O2/c1-15-21(16-13-28-32(2)14-16)31-33(18-6-4-3-5-7-18)24(15)30-25(35)29-22-19-9-8-17(27)12-20(19)26(10-11-26)23(22)34/h3-9,12-14,22-23,34H,10-11H2,1-2H3,(H2,29,30,35)/t22?,23-/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406118
PNG
(US10351575, Example 70)
Show SMILES Cc1c(NC(=O)NC2[C@H](O)Cc3ccc(Cl)cc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C24H23ClN6O2/c1-14-21(16-12-26-30(2)13-16)29-31(18-6-4-3-5-7-18)23(14)28-24(33)27-22-19-11-17(25)9-8-15(19)10-20(22)32/h3-9,11-13,20,22,32H,10H2,1-2H3,(H2,27,28,33)/t20-,22?/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406120
PNG
(US10351575, Example 72)
Show SMILES Cc1c(NC(=O)NC2[C@H](O)C(C)(C)c3ccccc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C26H28N6O2/c1-16-21(17-14-27-31(4)15-17)30-32(18-10-6-5-7-11-18)24(16)29-25(34)28-22-19-12-8-9-13-20(19)26(2,3)23(22)33/h5-15,22-23,33H,1-4H3,(H2,28,29,34)/t22?,23-/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406157
PNG
(1-(1',4-dimethyl-1- phenyl-1H,1'H-[3,4'- bipyrazol...)
Show SMILES Cc1c(NC(=O)NC2[C@H](O)CC(C)(C)c3ccccc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C27H30N6O2/c1-17-23(18-15-28-32(4)16-18)31-33(19-10-6-5-7-11-19)25(17)30-26(35)29-24-20-12-8-9-13-21(20)27(2,3)14-22(24)34/h5-13,15-16,22,24,34H,14H2,1-4H3,(H2,29,30,35)/t22-,24?/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406166
PNG
(1-(6- bromoisothiochroman-4- yl)-3-(1',4-dimethyl-...)
Show SMILES Cc1c(NC(=O)NC2CSCc3ccc(Br)cc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C24H23BrN6OS/c1-15-22(17-11-26-30(2)12-17)29-31(19-6-4-3-5-7-19)23(15)28-24(32)27-21-14-33-13-16-8-9-18(25)10-20(16)21/h3-12,21H,13-14H2,1-2H3,(H2,27,28,32)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406170
PNG
(1-(trans-2-hydroxy- 1,2,3,4- tetrhydronaphthalen-1...)
Show SMILES Cc1c(NC(=O)NC2[C@H](O)CCc3ccccc23)n(nc1-c1cnc(C)nc1)-c1ccccc1
Show InChI InChI=1S/C26H26N6O2/c1-16-23(19-14-27-17(2)28-15-19)31-32(20-9-4-3-5-10-20)25(16)30-26(34)29-24-21-11-7-6-8-18(21)12-13-22(24)33/h3-11,14-15,22,24,33H,12-13H2,1-2H3,(H2,29,30,34)/t22-,24?/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406178
PNG
(5-(3-(trans-2-hydroxy- 4,4-dimethyl-1,2,3,4- tetra...)
Show SMILES CNC(=O)c1nn(c(NC(=O)NC2[C@H](O)CC(C)(C)c3ccccc23)c1C)-c1ccccc1
Show InChI InChI=1S/C25H29N5O3/c1-15-20(23(32)26-4)29-30(16-10-6-5-7-11-16)22(15)28-24(33)27-21-17-12-8-9-13-18(17)25(2,3)14-19(21)31/h5-13,19,21,31H,14H2,1-4H3,(H,26,32)(H2,27,28,33)/t19-,21?/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406200
PNG
(1-(3-ethoxy-4-methyl-1-phenyl- 1H-pyrazol-5-yl)-3-...)
Show SMILES CCOc1nn(c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c1C)-c1ccccc1
Show InChI InChI=1S/C25H30N4O3/c1-5-32-23-16(2)22(29(28-23)17-11-7-6-8-12-17)27-24(31)26-21-18-13-9-10-14-19(18)25(3,4)15-20(21)30/h6-14,20-21,30H,5,15H2,1-4H3,(H2,26,27,31)/t20-,21-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406205
PNG
(US10351575, Example 151)
Show SMILES CC(C)N1CCO[C@@H](COc2nn(c(NC(=O)N[C@H]3[C@H](O)CC(C)(C)c4ccccc34)c2C)-c2ccccc2)C1
Show InChI InChI=1S/C31H41N5O4/c1-20(2)35-15-16-39-23(18-35)19-40-29-21(3)28(36(34-29)22-11-7-6-8-12-22)33-30(38)32-27-24-13-9-10-14-25(24)31(4,5)17-26(27)37/h6-14,20,23,26-27,37H,15-19H2,1-5H3,(H2,32,33,38)/t23-,26-,27-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406213
PNG
(US10351575, Example 156)
Show SMILES CNC(=O)c1nn(c(NC(=O)N[C@H]2[C@H](O)[C@@H](OC)C(C)(C)c3ccccc23)c1C)-c1ccccc1
Show InChI InChI=1S/C26H31N5O4/c1-15-19(24(33)27-4)30-31(16-11-7-6-8-12-16)23(15)29-25(34)28-20-17-13-9-10-14-18(17)26(2,3)22(35-5)21(20)32/h6-14,20-22,32H,1-5H3,(H,27,33)(H2,28,29,34)/t20-,21+,22-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406058
PNG
(US10351575, Example 12)
Show SMILES Cc1c(NC(=O)NC2CCOc3cc(F)ccc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C24H23FN6O2/c1-15-22(16-13-26-30(2)14-16)29-31(18-6-4-3-5-7-18)23(15)28-24(32)27-20-10-11-33-21-12-17(25)8-9-19(20)21/h3-9,12-14,20H,10-11H2,1-2H3,(H2,27,28,32)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406062
PNG
(1-(7-bromo-4,4-dimethyl- 1,2,3,4-tetrahydronaphtha...)
Show SMILES Cc1c(NC(=O)NC2CCC(C)(C)c3ccc(Br)cc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C27H29BrN6O/c1-17-24(18-15-29-33(4)16-18)32-34(20-8-6-5-7-9-20)25(17)31-26(35)30-23-12-13-27(2,3)22-11-10-19(28)14-21(22)23/h5-11,14-16,23H,12-13H2,1-4H3,(H2,30,31,35)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406091
PNG
(US10351575, Example 44)
Show SMILES CN1CCC(NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2ccc(=O)n(C)c2)c2cc(Cl)cc(F)c12
Show InChI InChI=1S/C27H26ClFN6O2/c1-16-24(17-9-10-23(36)34(3)15-17)32-35(19-7-5-4-6-8-19)26(16)31-27(37)30-22-11-12-33(2)25-20(22)13-18(28)14-21(25)29/h4-10,13-15,22H,11-12H2,1-3H3,(H2,30,31,37)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406102
PNG
(US10351575, Example 55)
Show SMILES Cc1c(NC(=O)NC2[C@H](O)C3(CC3)c3ccccc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C26H26N6O2/c1-16-21(17-14-27-31(2)15-17)30-32(18-8-4-3-5-9-18)24(16)29-25(34)28-22-19-10-6-7-11-20(19)26(12-13-26)23(22)33/h3-11,14-15,22-23,33H,12-13H2,1-2H3,(H2,28,29,34)/t22?,23-/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406103
PNG
(US10351575, Example 56)
Show SMILES Cc1c(NC(=O)NC2[C@H](O)C3(CC3)c3ccccc23)n(nc1-c1cnc(C)nc1)-c1ccccc1
Show InChI InChI=1S/C27H26N6O2/c1-16-22(18-14-28-17(2)29-15-18)32-33(19-8-4-3-5-9-19)25(16)31-26(35)30-23-20-10-6-7-11-21(20)27(12-13-27)24(23)34/h3-11,14-15,23-24,34H,12-13H2,1-2H3,(H2,30,31,35)/t23?,24-/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406106
PNG
(215-(3-(trans-2'-hydroxy-2',3'- dihydrospiro[cyclo...)
Show SMILES CNC(=O)c1nn(c(NC(=O)NC2[C@H](O)C3(CC3)c3ccccc23)c1C)-c1ccccc1
Show InChI InChI=1S/C24H25N5O3/c1-14-18(22(31)25-2)28-29(15-8-4-3-5-9-15)21(14)27-23(32)26-19-16-10-6-7-11-17(16)24(12-13-24)20(19)30/h3-11,19-20,30H,12-13H2,1-2H3,(H,25,31)(H2,26,27,32)/t19?,20-/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406107
PNG
(1-(trans-2'-hydroxy-2',3'- dihydrospiro[cyclopropa...)
Show SMILES COc1nn(c(NC(=O)NC2[C@H](O)C3(CC3)c3ccccc23)c1C)-c1ccccc1
Show InChI InChI=1S/C23H24N4O3/c1-14-20(27(26-21(14)30-2)15-8-4-3-5-9-15)25-22(29)24-18-16-10-6-7-11-17(16)23(12-13-23)19(18)28/h3-11,18-19,28H,12-13H2,1-2H3,(H2,24,25,29)/t18?,19-/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406119
PNG
(US10351575, Example 71)
Show SMILES Cc1c(NC(=O)NC2[C@H](O)Cc3ccc(Cl)cc23)n(nc1-c1cnc(C)nc1)-c1ccccc1
Show InChI InChI=1S/C25H23ClN6O2/c1-14-22(17-12-27-15(2)28-13-17)31-32(19-6-4-3-5-7-19)24(14)30-25(34)29-23-20-11-18(26)9-8-16(20)10-21(23)33/h3-9,11-13,21,23,33H,10H2,1-2H3,(H2,29,30,34)/t21-,23?/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406121
PNG
(US10351575, Example 73)
Show SMILES Cc1c(NC(=O)NC2[C@H](O)C(C)(C)c3ccccc23)n(nc1-c1cnc(C)nc1)-c1ccccc1
Show InChI InChI=1S/C27H28N6O2/c1-16-22(18-14-28-17(2)29-15-18)32-33(19-10-6-5-7-11-19)25(16)31-26(35)30-23-20-12-8-9-13-21(20)27(3,4)24(23)34/h5-15,23-24,34H,1-4H3,(H2,30,31,35)/t23?,24-/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406123
PNG
(US10351575, Example 75)
Show SMILES CN1CCO[C@@H](COc2nn(c(NC(=O)N[C@@H]3[C@@H](O)CC(C)(C)c4ccccc34)c2C)-c2ccccc2)C1
Show InChI InChI=1S/C29H37N5O4/c1-19-26(31-28(36)30-25-22-12-8-9-13-23(22)29(2,3)16-24(25)35)34(20-10-6-5-7-11-20)32-27(19)38-18-21-17-33(4)14-15-37-21/h5-13,21,24-25,35H,14-18H2,1-4H3,(H2,30,31,36)/t21-,24+,25+/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406130
PNG
(US10351575, Example 82)
Show SMILES COc1nn(c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c1C)-c1ccccc1
Show InChI InChI=1S/C24H26F2N4O3/c1-13-21(30(29-22(13)33-4)14-8-6-5-7-9-14)28-23(32)27-20-15-10-17(25)18(26)11-16(15)24(2,3)12-19(20)31/h5-11,19-20,31H,12H2,1-4H3,(H2,27,28,32)/t19-,20-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406135
PNG
(US10351575, Example 86)
Show SMILES CO[C@H]1[C@@H](O)[C@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnn(C)c2)c2ccccc2C1(C)C
Show InChI InChI=1S/C28H32N6O3/c1-17-22(18-15-29-33(4)16-18)32-34(19-11-7-6-8-12-19)26(17)31-27(36)30-23-20-13-9-10-14-21(20)28(2,3)25(37-5)24(23)35/h6-16,23-25,35H,1-5H3,(H2,30,31,36)/t23-,24+,25+/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406142
PNG
(US10351575, Example 93)
Show SMILES Cc1c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccc(F)cc23)n(nc1-c1ccc(=O)n(C)c1)-c1ccccc1
Show InChI InChI=1S/C29H30FN5O3/c1-17-25(18-10-13-24(37)34(4)16-18)33-35(20-8-6-5-7-9-20)27(17)32-28(38)31-26-21-14-19(30)11-12-22(21)29(2,3)15-23(26)36/h5-14,16,23,26,36H,15H2,1-4H3,(H2,31,32,38)/t23-,26-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406147
PNG
(US10351575, Example 97)
Show SMILES COc1nn(c(NC(=O)NC2[C@H](O)CC(C)(C)c3ccccc23)c1C)-c1ccccc1
Show InChI InChI=1S/C24H28N4O3/c1-15-21(28(27-22(15)31-4)16-10-6-5-7-11-16)26-23(30)25-20-17-12-8-9-13-18(17)24(2,3)14-19(20)29/h5-13,19-20,29H,14H2,1-4H3,(H2,25,26,30)/t19-,20?/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406161
PNG
(1-(1',4-dimethyl-1- phenyl-1H,1'H-[3,4'- bipyrazol...)
Show SMILES COCc1ccc2C(C)N(CC(F)(F)F)CC(NC(=O)Nc3c(C)c(nn3-c3ccccc3)-c3cnn(C)c3)c2c1
Show InChI InChI=1S/C29H32F3N7O2/c1-18-26(21-13-33-37(3)14-21)36-39(22-8-6-5-7-9-22)27(18)35-28(40)34-25-15-38(17-29(30,31)32)19(2)23-11-10-20(16-41-4)12-24(23)25/h5-14,19,25H,15-17H2,1-4H3,(H2,34,35,40)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406183
PNG
(5-(3-(6- (methoxymethyl)-1- methyl-2-(2,2,2- trifl...)
Show SMILES CNC(=O)c1nn(c(NC(=O)NC2CN(CC(F)(F)F)C(C)c3ccc(COC)cc23)c1C)-c1ccccc1
Show InChI InChI=1S/C27H31F3N6O3/c1-16-23(25(37)31-3)34-36(19-8-6-5-7-9-19)24(16)33-26(38)32-22-13-35(15-27(28,29)30)17(2)20-11-10-18(14-39-4)12-21(20)22/h5-12,17,22H,13-15H2,1-4H3,(H,31,37)(H2,32,33,38)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406190
PNG
(US10351575, Example 136)
Show SMILES Cc1c(NC(=O)NC2CN(CC(F)(F)F)C3(CC3)c3ccccc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C28H28F3N7O/c1-18-24(19-14-32-36(2)15-19)35-38(20-8-4-3-5-9-20)25(18)34-26(39)33-23-16-37(17-28(29,30)31)27(12-13-27)22-11-7-6-10-21(22)23/h3-11,14-15,23H,12-13,16-17H2,1-2H3,(H2,33,34,39)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406195
PNG
(US10351575, Example 141)
Show SMILES CN1CCO[C@@H](COc2nn(c(NC(=O)N[C@H]3[C@H](O)C4(CC4)c4ccccc34)c2Cl)-c2ccccc2)C1
Show InChI InChI=1S/C27H30ClN5O4/c1-32-13-14-36-18(15-32)16-37-25-21(28)24(33(31-25)17-7-3-2-4-8-17)30-26(35)29-22-19-9-5-6-10-20(19)27(11-12-27)23(22)34/h2-10,18,22-23,34H,11-16H2,1H3,(H2,29,30,35)/t18-,22-,23+/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406211
PNG
(1-((r-1,t-2,t-3)-2-hydroxy- 3-methoxy-4,4-dimethyl...)
Show SMILES CO[C@H]1[C@@H](O)[C@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2ccc(=O)n(C)c2)c2ccccc2C1(C)C
Show InChI InChI=1S/C30H33N5O4/c1-18-24(19-15-16-23(36)34(4)17-19)33-35(20-11-7-6-8-12-20)28(18)32-29(38)31-25-21-13-9-10-14-22(21)30(2,3)27(39-5)26(25)37/h6-17,25-27,37H,1-5H3,(H2,31,32,38)/t25-,26+,27+/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406214
PNG
(1-(1',4-dimethyl-1- phenyl-1H,1'H-[3,4'- bipyrazol...)
Show SMILES CO[C@@H]1[C@@H](O)[C@H](NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnn(C)c2)c2ccccc2C1(C)C
Show InChI InChI=1S/C28H32N6O3/c1-17-22(18-15-29-33(4)16-18)32-34(19-11-7-6-8-12-19)26(17)31-27(36)30-23-20-13-9-10-14-21(20)28(2,3)25(37-5)24(23)35/h6-16,23-25,35H,1-5H3,(H2,30,31,36)/t23-,24+,25-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406055
PNG
(1-(1',4-dimethyl-1-phenyl- 1H,1'H-3,4'-bipyrazol-5...)
Show SMILES Cc1c(NC(=O)NC2CC(C)(C)Oc3ccccc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C26H28N6O2/c1-17-23(18-15-27-31(4)16-18)30-32(19-10-6-5-7-11-19)24(17)29-25(33)28-21-14-26(2,3)34-22-13-9-8-12-20(21)22/h5-13,15-16,21H,14H2,1-4H3,(H2,28,29,33)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406191
PNG
(US10351575, Example 137 | US10351575, Example 138)
Show SMILES Cc1c(NC(=O)N[C@H]2[C@H](O)C3(CC3)c3ccccc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C26H26N6O2/c1-16-21(17-14-27-31(2)15-17)30-32(18-8-4-3-5-9-18)24(16)29-25(34)28-22-19-10-6-7-11-20(19)26(12-13-26)23(22)33/h3-11,14-15,22-23,33H,12-13H2,1-2H3,(H2,28,29,34)/t22-,23+/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406060
PNG
(1-(1',4-dimethyl-1-phenyl- 1H,1'H-[3,4'-bipyrazol]...)
Show SMILES CC1CC(NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnn(C)c2)c2cc(F)ccc2O1
Show InChI InChI=1S/C25H25FN6O2/c1-15-11-21(20-12-18(26)9-10-22(20)34-15)28-25(33)29-24-16(2)23(17-13-27-31(3)14-17)30-32(24)19-7-5-4-6-8-19/h4-10,12-15,21H,11H2,1-3H3,(H2,28,29,33)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406083
PNG
(US10351575, Example 36)
Show SMILES Cc1c(NC(=O)NC2CCC(=O)c3ccccc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C25H24N6O2/c1-16-23(17-14-26-30(2)15-17)29-31(18-8-4-3-5-9-18)24(16)28-25(33)27-21-12-13-22(32)20-11-7-6-10-19(20)21/h3-11,14-15,21H,12-13H2,1-2H3,(H2,27,28,33)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406097
PNG
(US10351575, Example 50)
Show SMILES COCCO[C@@H]1Cc2ccccc2[C@H]1NC(=O)Nc1c2CCCc2nn1-c1ccccc1
Show InChI InChI=1S/C25H28N4O3/c1-31-14-15-32-22-16-17-8-5-6-11-19(17)23(22)26-25(30)27-24-20-12-7-13-21(20)28-29(24)18-9-3-2-4-10-18/h2-6,8-11,22-23H,7,12-16H2,1H3,(H2,26,27,30)/t22-,23-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406069
PNG
(US10351575, Example 23)
Show SMILES COCCN1CC(NC(=O)Nc2c3CCCc3nn2-c2ccccc2)c2ccccc2C1
Show InChI InChI=1S/C25H29N5O2/c1-32-15-14-29-16-18-8-5-6-11-20(18)23(17-29)26-25(31)27-24-21-12-7-13-22(21)28-30(24)19-9-3-2-4-10-19/h2-6,8-11,23H,7,12-17H2,1H3,(H2,26,27,31)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406098
PNG
(US10351575, Example 51)
Show SMILES COCCO[C@H]1Cc2ccccc2[C@@H]1NC(=O)Nc1c(C)c(nn1-c1ccccc1)-c1cnn(C)c1
Show InChI InChI=1S/C27H30N6O3/c1-18-24(20-16-28-32(2)17-20)31-33(21-10-5-4-6-11-21)26(18)30-27(34)29-25-22-12-8-7-9-19(22)15-23(25)36-14-13-35-3/h4-12,16-17,23,25H,13-15H2,1-3H3,(H2,29,30,34)/t23-,25-/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406059
PNG
(1-(3-ethoxy-4-methyl-1-phenyl- 1H-pyrazol-5-yl)-3-...)
Show SMILES CCOc1nn(c(NC(=O)NC2CCOc3cc(F)ccc23)c1C)-c1ccccc1
Show InChI InChI=1S/C22H23FN4O3/c1-3-29-21-14(2)20(27(26-21)16-7-5-4-6-8-16)25-22(28)24-18-11-12-30-19-13-15(23)9-10-17(18)19/h4-10,13,18H,3,11-12H2,1-2H3,(H2,24,25,28)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406181
PNG
(1-(trans-6-hydroxy- 6,7,8,9-tetrahydro-5H- benzo[7...)
Show SMILES Cc1c(NC(=O)NC2[C@H](O)CCCc3ccccc23)n(nc1-c1cnc(C)nc1)-c1ccccc1
Show InChI InChI=1S/C27H28N6O2/c1-17-24(20-15-28-18(2)29-16-20)32-33(21-11-4-3-5-12-21)26(17)31-27(35)30-25-22-13-7-6-9-19(22)10-8-14-23(25)34/h3-7,9,11-13,15-16,23,25,34H,8,10,14H2,1-2H3,(H2,30,31,35)/t23-,25?/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406063
PNG
(US10351575, Example 17)
Show SMILES COCCN1CCc2ccccc2C(C1)NC(=O)Nc1c(C)c(nn1-c1ccccc1)-c1cnn(C)c1
Show InChI InChI=1S/C28H33N7O2/c1-20-26(22-17-29-33(2)18-22)32-35(23-10-5-4-6-11-23)27(20)31-28(36)30-25-19-34(15-16-37-3)14-13-21-9-7-8-12-24(21)25/h4-12,17-18,25H,13-16,19H2,1-3H3,(H2,30,31,36)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406064
PNG
(1-(1',4-dimethyl- 1-phenyl-1H,1'H- 3,4'-bipyrazol-...)
Show SMILES Cc1c(NC(=O)NC2CN(CC(F)(F)F)CCc3ccccc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C27H28F3N7O/c1-18-24(20-14-31-35(2)15-20)34-37(21-9-4-3-5-10-21)25(18)33-26(38)32-23-16-36(17-27(28,29)30)13-12-19-8-6-7-11-22(19)23/h3-11,14-15,23H,12-13,16-17H2,1-2H3,(H2,32,33,38)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406065
PNG
(1-(3-acetyl- 2,3,4,5- tetrahydro-1H- benzo[d]azepi...)
Show SMILES CC(=O)N1CCc2ccccc2C(C1)NC(=O)Nc1c(C)c(nn1-c1ccccc1)-c1cnn(C)c1
Show InChI InChI=1S/C27H29N7O2/c1-18-25(21-15-28-32(3)16-21)31-34(22-10-5-4-6-11-22)26(18)30-27(36)29-24-17-33(19(2)35)14-13-20-9-7-8-12-23(20)24/h4-12,15-16,24H,13-14,17H2,1-3H3,(H2,29,30,36)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406090
PNG
(US10351575, Example 43)
Show SMILES CN1CCC(NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2ccc(=O)n(C)c2)c2cccc(F)c12
Show InChI InChI=1S/C27H27FN6O2/c1-17-24(18-12-13-23(35)33(3)16-18)31-34(19-8-5-4-6-9-19)26(17)30-27(36)29-22-14-15-32(2)25-20(22)10-7-11-21(25)28/h4-13,16,22H,14-15H2,1-3H3,(H2,29,30,36)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406054
PNG
(1-(1',4-dimethyl-1-phenyl- 1H,1'H-3,4'-bipyrazol-5...)
Show SMILES Cc1c(NC(=O)NC2COCc3ccccc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C24H24N6O2/c1-16-22(18-12-25-29(2)13-18)28-30(19-9-4-3-5-10-19)23(16)27-24(31)26-21-15-32-14-17-8-6-7-11-20(17)21/h3-13,21H,14-15H2,1-2H3,(H2,26,27,31)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406180
PNG
(1-(3,4-dimethyl-1- phenyl-1H-pyrazol-5-yl)- 3-(tra...)
Show SMILES Cc1nn(c(NC(=O)NC2[C@H](O)CCCc3ccccc23)c1C)-c1ccccc1
Show InChI InChI=1S/C23H26N4O2/c1-15-16(2)26-27(18-11-4-3-5-12-18)22(15)25-23(29)24-21-19-13-7-6-9-17(19)10-8-14-20(21)28/h3-7,9,11-13,20-21,28H,8,10,14H2,1-2H3,(H2,24,25,29)/t20-,21?/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406199
PNG
(1-((1R,2R)-2-hydroxy-4,4- dimethyl-1,2,3,4- tetrah...)
Show SMILES Cn1nc(cc1NC(=O)N[C@H]1[C@H](O)CC(C)(C)c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C23H26N4O2/c1-23(2)14-19(28)21(16-11-7-8-12-17(16)23)25-22(29)24-20-13-18(26-27(20)3)15-9-5-4-6-10-15/h4-13,19,21,28H,14H2,1-3H3,(H2,24,25,29)/t19-,21-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406053
PNG
(1-(chroman-4-yl)-3-(1',4- dimethyl-1-phenyl-1H,1'H...)
Show SMILES Cc1c(NC(=O)NC2CCOc3ccccc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C24H24N6O2/c1-16-22(17-14-25-29(2)15-17)28-30(18-8-4-3-5-9-18)23(16)27-24(31)26-20-12-13-32-21-11-7-6-10-19(20)21/h3-11,14-15,20H,12-13H2,1-2H3,(H2,26,27,31)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406066
PNG
(1-(1',4-dimethyl- 1-phenyl-1H,1'H- 3,4'-bipyrazol-...)
Show SMILES CCC(=O)N1CCc2ccccc2C(C1)NC(=O)Nc1c(C)c(nn1-c1ccccc1)-c1cnn(C)c1
Show InChI InChI=1S/C28H31N7O2/c1-4-25(36)34-15-14-20-10-8-9-13-23(20)24(18-34)30-28(37)31-27-19(2)26(21-16-29-33(3)17-21)32-35(27)22-11-6-5-7-12-22/h5-13,16-17,24H,4,14-15,18H2,1-3H3,(H2,30,31,37)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406068
PNG
(US10351575, Example 22)
Show SMILES CCN1CC(NC(=O)Nc2c3CCCc3nn2-c2ccccc2)c2ccccc2C1
Show InChI InChI=1S/C24H27N5O/c1-2-28-15-17-9-6-7-12-19(17)22(16-28)25-24(30)26-23-20-13-8-14-21(20)27-29(23)18-10-4-3-5-11-18/h3-7,9-12,22H,2,8,13-16H2,1H3,(H2,25,26,30)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406081
PNG
(US10351575, Example 35A | US10351575, Example 35B)
Show SMILES COCc1ccc2OC3(CCC3)CC(NC(=O)Nc3c(C)c(nn3-c3ccccc3)-c3cnn(C)c3)c2c1
Show InChI InChI=1S/C29H32N6O3/c1-19-26(21-16-30-34(2)17-21)33-35(22-8-5-4-6-9-22)27(19)32-28(36)31-24-15-29(12-7-13-29)38-25-11-10-20(18-37-3)14-23(24)25/h4-6,8-11,14,16-17,24H,7,12-13,15,18H2,1-3H3,(H2,31,32,36)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406100
PNG
(US10351575, Example 53)
Show SMILES CCOc1nn(c(NC(=O)NC2CCc3ccccc23)c1C)-c1ccccc1
Show InChI InChI=1S/C22H24N4O2/c1-3-28-21-15(2)20(26(25-21)17-10-5-4-6-11-17)24-22(27)23-19-14-13-16-9-7-8-12-18(16)19/h4-12,19H,3,13-14H2,1-2H3,(H2,23,24,27)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406182
PNG
(1-(trans-6-hydroxy- 6,7,8,9-tetrahydro-5H- benzo[7...)
Show SMILES COc1ncc(cn1)-c1nn(c(NC(=O)NC2[C@H](O)CCCc3ccccc23)c1C)-c1ccccc1
Show InChI InChI=1S/C27H28N6O3/c1-17-23(19-15-28-27(36-2)29-16-19)32-33(20-11-4-3-5-12-20)25(17)31-26(35)30-24-21-13-7-6-9-18(21)10-8-14-22(24)34/h3-7,9,11-13,15-16,22,24,34H,8,10,14H2,1-2H3,(H2,30,31,35)/t22-,24?/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406067
PNG
(US10351575, Example 21)
Show SMILES CCCN1CCc2ccccc2C(C1)NC(=O)Nc1c(C)c(nn1-c1ccccc1)-c1cnn(C)c1
Show InChI InChI=1S/C28H33N7O/c1-4-15-34-16-14-21-10-8-9-13-24(21)25(19-34)30-28(36)31-27-20(2)26(22-17-29-33(3)18-22)32-35(27)23-11-6-5-7-12-23/h5-13,17-18,25H,4,14-16,19H2,1-3H3,(H2,30,31,36)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406085
PNG
(US10351575, Example 38)
Show SMILES Cc1c(NC(=O)Nc2cn(CC(F)(F)F)c(=O)c3ccccc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C26H22F3N7O2/c1-16-22(17-12-30-34(2)13-17)33-36(18-8-4-3-5-9-18)23(16)32-25(38)31-21-14-35(15-26(27,28)29)24(37)20-11-7-6-10-19(20)21/h3-14H,15H2,1-2H3,(H2,31,32,38)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406095
PNG
(US10351575, Example 48)
Show SMILES COCCO[C@H]1Cc2ccccc2[C@@H]1NC(=O)Nc1c2CCCc2nn1-c1ccccc1
Show InChI InChI=1S/C25H28N4O3/c1-31-14-15-32-22-16-17-8-5-6-11-19(17)23(22)26-25(30)27-24-20-12-7-13-21(20)28-29(24)18-9-3-2-4-10-18/h2-6,8-11,22-23H,7,12-16H2,1H3,(H2,26,27,30)/t22-,23-/m0/s1
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n/an/a 550n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406096
PNG
(US10351575, Example 49)
Show SMILES CCOc1nn(c(NC(=O)N[C@@H]2[C@H](Cc3ccccc23)OCCOC)c1C)-c1ccccc1
Show InChI InChI=1S/C25H30N4O4/c1-4-32-24-17(2)23(29(28-24)19-11-6-5-7-12-19)27-25(30)26-22-20-13-9-8-10-18(20)16-21(22)33-15-14-31-3/h5-13,21-22H,4,14-16H2,1-3H3,(H2,26,27,30)/t21-,22-/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406165
PNG
(1-(6-bromo-1,1- dioxidothiochroman-4- yl)-3-(1',4-...)
Show SMILES Cc1c(NC(=O)NC2CCS(=O)(=O)c3ccc(Br)cc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C24H23BrN6O3S/c1-15-22(16-13-26-30(2)14-16)29-31(18-6-4-3-5-7-18)23(15)28-24(32)27-20-10-11-35(33,34)21-9-8-17(25)12-19(20)21/h3-9,12-14,20H,10-11H2,1-2H3,(H2,27,28,32)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406050
PNG
((R)-1-(1',4-dimethyl-1-phenyl- 1H,1'H-3,4'-bipyraz...)
Show SMILES Cc1c(NC(=O)N[C@@H]2CCCc3ccccc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C25H26N6O/c1-17-23(19-15-26-30(2)16-19)29-31(20-11-4-3-5-12-20)24(17)28-25(32)27-22-14-8-10-18-9-6-7-13-21(18)22/h3-7,9,11-13,15-16,22H,8,10,14H2,1-2H3,(H2,27,28,32)/t22-/m1/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406087
PNG
(US10351575, Example 40)
Show SMILES CN1CCC(NC(=O)Nc2c(C)c(nn2-c2ccccc2)-c2cnn(C)c2)c2ccccc12
Show InChI InChI=1S/C25H27N7O/c1-17-23(18-15-26-31(3)16-18)29-32(19-9-5-4-6-10-19)24(17)28-25(33)27-21-13-14-30(2)22-12-8-7-11-20(21)22/h4-12,15-16,21H,13-14H2,1-3H3,(H2,27,28,33)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406099
PNG
(US10351575, Example 52)
Show SMILES COCCO[C@H]1Cc2ccccc2[C@@H]1NC(=O)Nc1c(Br)c(C)nn1-c1ccccc1
Show InChI InChI=1S/C23H25BrN4O3/c1-15-20(24)22(28(27-15)17-9-4-3-5-10-17)26-23(29)25-21-18-11-7-6-8-16(18)14-19(21)31-13-12-30-2/h3-11,19,21H,12-14H2,1-2H3,(H2,25,26,29)/t19-,21-/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406051
PNG
(1-(1',4-dimethyl-1-phenyl- 1H,1'H-3,4'-bipyrazol-5...)
Show SMILES COc1ccc2C(CCCc2c1)NC(=O)Nc1c(C)c(nn1-c1ccccc1)-c1cnn(C)c1
Show InChI InChI=1S/C26H28N6O2/c1-17-24(19-15-27-31(2)16-19)30-32(20-9-5-4-6-10-20)25(17)29-26(33)28-23-11-7-8-18-14-21(34-3)12-13-22(18)23/h4-6,9-10,12-16,23H,7-8,11H2,1-3H3,(H2,28,29,33)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406070
PNG
(US10351575, Example 24)
Show SMILES CC(=O)N1CC(NC(=O)Nc2c3CCCc3nn2-c2ccccc2)c2ccccc2C1
Show InChI InChI=1S/C24H25N5O2/c1-16(30)28-14-17-8-5-6-11-19(17)22(15-28)25-24(31)26-23-20-12-7-13-21(20)27-29(23)18-9-3-2-4-10-18/h2-6,8-11,22H,7,12-15H2,1H3,(H2,25,26,31)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406084
PNG
(US10351575, Example 37)
Show SMILES Cc1c(NC(=O)NC2CCC(C)(O)c3ccccc23)n(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C26H28N6O2/c1-17-23(18-15-27-31(3)16-18)30-32(19-9-5-4-6-10-19)24(17)29-25(33)28-22-13-14-26(2,34)21-12-8-7-11-20(21)22/h4-12,15-16,22,34H,13-14H2,1-3H3,(H2,28,29,33)
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406094
PNG
(US10351575, Example 47)
Show SMILES CO[C@H]1Cc2ccccc2[C@@H]1NC(=O)Nc1c2CCCc2nn1-c1ccccc1
Show InChI InChI=1S/C23H24N4O2/c1-29-20-14-15-8-5-6-11-17(15)21(20)24-23(28)25-22-18-12-7-13-19(18)26-27(22)16-9-3-2-4-10-16/h2-6,8-11,20-21H,7,12-14H2,1H3,(H2,24,25,28)/t20-,21-/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406101
PNG
(US10351575, Example 54)
Show SMILES CCOc1nn(c(NC(=O)N[C@H]2CCc3ccccc23)c1C)-c1ccccc1
Show InChI InChI=1S/C22H24N4O2/c1-3-28-21-15(2)20(26(25-21)17-10-5-4-6-11-17)24-22(27)23-19-14-13-16-9-7-8-12-18(16)19/h4-12,19H,3,13-14H2,1-2H3,(H2,23,24,27)/t19-/m0/s1
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Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406148
PNG
(US10351575, Example 98)
Show SMILES Cc1nn(c(NC(=O)NC2[C@H](O)CC(C)(C)c3ccc(cc23)C(N)=O)c1C)-c1ccccc1
Show InChI InChI=1S/C25H29N5O3/c1-14-15(2)29-30(17-8-6-5-7-9-17)23(14)28-24(33)27-21-18-12-16(22(26)32)10-11-19(18)25(3,4)13-20(21)31/h5-12,20-21,31H,13H2,1-4H3,(H2,26,32)(H2,27,28,33)/t20-,21?/m1/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM406189
PNG
(US10351575, Example 135)
Show SMILES COc1nn(c(NC(=O)N[C@H]2[C@@H](O)CCc3ccccc23)c1C)-c1ccccc1
Show InChI InChI=1S/C22H24N4O3/c1-14-20(26(25-21(14)29-2)16-9-4-3-5-10-16)24-22(28)23-19-17-11-7-6-8-15(17)12-13-18(19)27/h3-11,18-19,27H,12-13H2,1-2H3,(H2,23,24,28)/t18-,19+/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...


US Patent US10351575 (2019)


BindingDB Entry DOI: 10.7270/Q2DR2XV2
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%