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Patent code US10357493

Compile Data Set for Download or QSAR

Found 402 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408335
PNG
(N-(1-(2-chlorophenyl)cyclopropyl)-5-(5-(difluorome...)
Show SMILES FC(F)c1nnc(o1)-c1cnc(NC2(CC2)c2ccccc2Cl)nc1
Show InChI InChI=1S/C16H12ClF2N5O/c17-11-4-2-1-3-10(11)16(5-6-16)22-15-20-7-9(8-21-15)13-23-24-14(25-13)12(18)19/h1-4,7-8,12H,5-6H2,(H,20,21,22)
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n/an/a 6n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408339
PNG
(5-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)-N-(1-(...)
Show SMILES FC(F)c1nnc(o1)-c1cnc(NC2(CC2)c2ccccc2F)nc1
Show InChI InChI=1S/C16H12F3N5O/c17-11-4-2-1-3-10(11)16(5-6-16)22-15-20-7-9(8-21-15)13-23-24-14(25-13)12(18)19/h1-4,7-8,12H,5-6H2,(H,20,21,22)
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n/an/a 6n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408288
PNG
(5-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)-N-(1-(...)
Show SMILES FC(F)c1nnc(o1)-c1cnc(NC2(CC2)c2c(F)cccc2F)nc1
Show InChI InChI=1S/C16H11F4N5O/c17-9-2-1-3-10(18)11(9)16(4-5-16)23-15-21-6-8(7-22-15)13-24-25-14(26-13)12(19)20/h1-3,6-7,12H,4-5H2,(H,21,22,23)
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n/an/a 6n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408345
PNG
(N-(1-(2-chloro-4-fluorophenyl)cyclopropyl)-5-(5-(d...)
Show SMILES FC(F)c1nnc(o1)-c1cnc(NC2(CC2)c2ccc(F)cc2Cl)nc1
Show InChI InChI=1S/C16H11ClF3N5O/c17-11-5-9(18)1-2-10(11)16(3-4-16)23-15-21-6-8(7-22-15)13-24-25-14(26-13)12(19)20/h1-2,5-7,12H,3-4H2,(H,21,22,23)
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n/an/a 8n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408287
PNG
(5-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)-N-(1-(...)
Show SMILES FC(F)c1nnc(o1)-c1cnc(NC2(CC2)c2ccc(F)cc2F)nc1
Show InChI InChI=1S/C16H11F4N5O/c17-9-1-2-10(11(18)5-9)16(3-4-16)23-15-21-6-8(7-22-15)13-24-25-14(26-13)12(19)20/h1-2,5-7,12H,3-4H2,(H,21,22,23)
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n/an/a 9n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408359
PNG
(N-(1-(5-chloro-2-fluorophenyl)cyclopropyl)-5-(5-(d...)
Show SMILES FC(F)c1nnc(o1)-c1cnc(NC2(CC2)c2cc(Cl)ccc2F)nc1
Show InChI InChI=1S/C16H11ClF3N5O/c17-9-1-2-11(18)10(5-9)16(3-4-16)23-15-21-6-8(7-22-15)13-24-25-14(26-13)12(19)20/h1-2,5-7,12H,3-4H2,(H,21,22,23)
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n/an/a 14n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408340
PNG
(5-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)-N-(1-(...)
Show SMILES FC(F)c1nnc(o1)-c1cnc(NC2(CC2)c2cccc(F)c2)nc1
Show InChI InChI=1S/C16H12F3N5O/c17-11-3-1-2-10(6-11)16(4-5-16)22-15-20-7-9(8-21-15)13-23-24-14(25-13)12(18)19/h1-3,6-8,12H,4-5H2,(H,20,21,22)
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n/an/a 15n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408334
PNG
(N-(1-(3-chlorophenyl)cyclopropyl)-5-(5-(difluorome...)
Show SMILES FC(F)c1nnc(o1)-c1cnc(NC2(CC2)c2cccc(Cl)c2)nc1
Show InChI InChI=1S/C16H12ClF2N5O/c17-11-3-1-2-10(6-11)16(4-5-16)22-15-20-7-9(8-21-15)13-23-24-14(25-13)12(18)19/h1-3,6-8,12H,4-5H2,(H,20,21,22)
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n/an/a 15n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408320
PNG
(US10357493, Example 38(+))
Show SMILES CS(=O)(=O)NC[C@H](Nc1ncc(cn1)-c1nnc(o1)C(F)F)c1ccc(F)cc1
Show InChI InChI=1S/C16H15F3N6O3S/c1-29(26,27)22-8-12(9-2-4-11(17)5-3-9)23-16-20-6-10(7-21-16)14-24-25-15(28-14)13(18)19/h2-7,12-13,22H,8H2,1H3,(H,20,21,23)/t12-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408332
PNG
(5-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)-N-(1-(...)
Show SMILES FC(F)c1nnc(o1)-c1cnc(NC2(CC2)c2cccc(c2)C(F)(F)F)nc1
Show InChI InChI=1S/C17H12F5N5O/c18-12(19)14-27-26-13(28-14)9-7-23-15(24-8-9)25-16(4-5-16)10-2-1-3-11(6-10)17(20,21)22/h1-3,6-8,12H,4-5H2,(H,23,24,25)
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n/an/a 16n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408388
PNG
(N-(2-((5-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)...)
Show SMILES CS(=O)(=O)NC[C@H](Nc1ncc(cn1)-c1nnc(o1)C(F)F)c1ccc(F)cc1F
Show InChI InChI=1S/C16H14F4N6O3S/c1-30(27,28)23-7-12(10-3-2-9(17)4-11(10)18)24-16-21-5-8(6-22-16)14-25-26-15(29-14)13(19)20/h2-6,12-13,23H,7H2,1H3,(H,21,22,24)/t12-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408380
PNG
(US10357493, Example 98)
Show SMILES CC(C)(Nc1ncc(cn1)-c1nnc(o1)C(F)F)c1c(F)cccc1F
Show InChI InChI=1S/C16H13F4N5O/c1-16(2,11-9(17)4-3-5-10(11)18)23-15-21-6-8(7-22-15)13-24-25-14(26-13)12(19)20/h3-7,12H,1-2H3,(H,21,22,23)
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n/an/a 16n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408390
PNG
(US10357493, Example 106)
Show SMILES COc1cc(F)c(c(F)c1)C1(CC1)Nc1ncc(cn1)-c1nnc(o1)C(F)F
Show InChI InChI=1S/C17H13F4N5O2/c1-27-9-4-10(18)12(11(19)5-9)17(2-3-17)24-16-22-6-8(7-23-16)14-25-26-15(28-14)13(20)21/h4-7,13H,2-3H2,1H3,(H,22,23,24)
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n/an/a 16n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408400
PNG
(N-(2-(4-(difluoromethoxy)-2-fluorophenyl)-2-((5-(5...)
Show SMILES CS(=O)(=O)NC[C@H](Nc1ncc(cn1)-c1nnc(o1)C(F)F)c1ccc(OC(F)F)cc1F
Show InChI InChI=1S/C17H15F5N6O4S/c1-33(29,30)25-7-12(10-3-2-9(4-11(10)18)31-16(21)22)26-17-23-5-8(6-24-17)14-27-28-15(32-14)13(19)20/h2-6,12-13,16,25H,7H2,1H3,(H,23,24,26)/t12-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408356
PNG
(N-(1-(3-chloro-2-fluorophenyl)cyclopropyl)-5-(5-(d...)
Show SMILES FC(F)c1nnc(o1)-c1cnc(NC2(CC2)c2cccc(Cl)c2F)nc1
Show InChI InChI=1S/C16H11ClF3N5O/c17-10-3-1-2-9(11(10)18)16(4-5-16)23-15-21-6-8(7-22-15)13-24-25-14(26-13)12(19)20/h1-3,6-7,12H,4-5H2,(H,21,22,23)
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n/an/a 17n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408398
PNG
(N-(2-(4-(difluoromethoxy)phenyl)-2-((5-(5-(difluor...)
Show SMILES CS(=O)(=O)NC[C@H](Nc1ncc(cn1)-c1nnc(o1)C(F)F)c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C17H16F4N6O4S/c1-32(28,29)24-8-12(9-2-4-11(5-3-9)30-16(20)21)25-17-22-6-10(7-23-17)14-26-27-15(31-14)13(18)19/h2-7,12-13,16,24H,8H2,1H3,(H,22,23,25)/t12-/m0/s1
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n/an/a 18n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408431
PNG
(N-(2-(4-(difluoromethoxy)-2-fluorophenyl)-2-((5-(5...)
Show SMILES CCS(=O)(=O)NCC(Nc1ncc(cn1)-c1nnc(o1)C(F)F)c1ccc(OC(F)F)cc1F
Show InChI InChI=1S/C18H17F5N6O4S/c1-2-34(30,31)26-8-13(11-4-3-10(5-12(11)19)32-17(22)23)27-18-24-6-9(7-25-18)15-28-29-16(33-15)14(20)21/h3-7,13-14,17,26H,2,8H2,1H3,(H,24,25,27)
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n/an/a 18n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408432
PNG
(N-(2-(4-(difluoromethoxy)-2-fluorophenyl)-2-((5-(5...)
Show SMILES CCS(=O)(=O)N(C)CC(Nc1ncc(cn1)-c1nnc(o1)C(F)F)c1ccc(OC(F)F)cc1F
Show InChI InChI=1S/C19H19F5N6O4S/c1-3-35(31,32)30(2)9-14(12-5-4-11(6-13(12)20)33-18(23)24)27-19-25-7-10(8-26-19)16-28-29-17(34-16)15(21)22/h4-8,14-15,18H,3,9H2,1-2H3,(H,25,26,27)
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n/an/a 19n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408357
PNG
(5-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)-N-(1-(...)
Show SMILES FC(F)c1nnc(o1)-c1cnc(NC2(CC2)c2c(F)cc(F)cc2F)nc1
Show InChI InChI=1S/C16H10F5N5O/c17-8-3-9(18)11(10(19)4-8)16(1-2-16)24-15-22-5-7(6-23-15)13-25-26-14(27-13)12(20)21/h3-6,12H,1-2H2,(H,22,23,24)
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n/an/a 19n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408437
PNG
(N-(2-((5-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)...)
Show SMILES CN(CC(Nc1ncc(cn1)-c1nnc(o1)C(F)F)c1ccc(OC(F)(F)F)cc1F)S(=O)(=O)C1CC1
Show InChI InChI=1S/C20H18F6N6O4S/c1-32(37(33,34)12-3-4-12)9-15(13-5-2-11(6-14(13)21)36-20(24,25)26)29-19-27-7-10(8-28-19)17-30-31-18(35-17)16(22)23/h2,5-8,12,15-16H,3-4,9H2,1H3,(H,27,28,29)
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n/an/a 20n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408338
PNG
(5-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)-N-(1-(...)
Show SMILES FC(F)c1nnc(o1)-c1cnc(NC2(CC2)c2ccccc2OC(F)(F)F)nc1
Show InChI InChI=1S/C17H12F5N5O2/c18-12(19)14-27-26-13(28-14)9-7-23-15(24-8-9)25-16(5-6-16)10-3-1-2-4-11(10)29-17(20,21)22/h1-4,7-8,12H,5-6H2,(H,23,24,25)
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n/an/a 20n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408342
PNG
(5-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)-N-(1-(...)
Show SMILES FC(F)c1nnc(o1)-c1cnc(NC2(CC2)c2ccc(F)c(F)c2)nc1
Show InChI InChI=1S/C16H11F4N5O/c17-10-2-1-9(5-11(10)18)16(3-4-16)23-15-21-6-8(7-22-15)13-24-25-14(26-13)12(19)20/h1-2,5-7,12H,3-4H2,(H,21,22,23)
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n/an/a 21n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408396
PNG
(US10357493, Example 113)
Show SMILES CN(CC(Nc1ncc(cn1)-c1nnc(o1)C(F)F)c1ccc(F)cc1)S(C)(=O)=O
Show InChI InChI=1S/C17H17F3N6O3S/c1-26(30(2,27)28)9-13(10-3-5-12(18)6-4-10)23-17-21-7-11(8-22-17)15-24-25-16(29-15)14(19)20/h3-8,13-14H,9H2,1-2H3,(H,21,22,23)
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n/an/a 21n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408376
PNG
(US10357493, Example 91)
Show SMILES FC(F)c1nnc(o1)-c1cnc(NC2(CC2)c2cccc(F)c2Cl)nc1
Show InChI InChI=1S/C16H11ClF3N5O/c17-11-9(2-1-3-10(11)18)16(4-5-16)23-15-21-6-8(7-22-15)13-24-25-14(26-13)12(19)20/h1-3,6-7,12H,4-5H2,(H,21,22,23)
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n/an/a 21n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408300
PNG
(US10357493, Example 20(+))
Show SMILES C[C@H](Nc1ncc(cn1)-c1nnc(o1)C(F)F)c1ccc(F)cc1
Show InChI InChI=1S/C15H12F3N5O/c1-8(9-2-4-11(16)5-3-9)21-15-19-6-10(7-20-15)13-22-23-14(24-13)12(17)18/h2-8,12H,1H3,(H,19,20,21)/t8-/m0/s1
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n/an/a 21n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408385
PNG
(US10357493, Example 101(+))
Show SMILES FC(F)c1nnc(o1)-c1cnc(N[C@@H](CC(F)(F)F)c2ccc(F)cc2F)nc1
Show InChI InChI=1S/C16H10F7N5O/c17-8-1-2-9(10(18)3-8)11(4-16(21,22)23)26-15-24-5-7(6-25-15)13-27-28-14(29-13)12(19)20/h1-3,5-6,11-12H,4H2,(H,24,25,26)/t11-/m0/s1
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n/an/a 22n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408344
PNG
(5-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)-N-(1-(...)
Show SMILES FC(F)c1nnc(o1)-c1cnc(NC2(CC2)c2cc(F)ccc2F)nc1
Show InChI InChI=1S/C16H11F4N5O/c17-9-1-2-11(18)10(5-9)16(3-4-16)23-15-21-6-8(7-22-15)13-24-25-14(26-13)12(19)20/h1-2,5-7,12H,3-4H2,(H,21,22,23)
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Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408337
PNG
(5-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)-N-(1-(...)
Show SMILES FC(F)c1nnc(o1)-c1cnc(NC2(CC2)c2ccc(OC(F)(F)F)cc2)nc1
Show InChI InChI=1S/C17H12F5N5O2/c18-12(19)14-27-26-13(28-14)9-7-23-15(24-8-9)25-16(5-6-16)10-1-3-11(4-2-10)29-17(20,21)22/h1-4,7-8,12H,5-6H2,(H,23,24,25)
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n/an/a 22n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408343
PNG
(5-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)-N-(1-(...)
Show SMILES FC(F)c1nnc(o1)-c1cnc(NC2(CC2)c2cccc(F)c2F)nc1
Show InChI InChI=1S/C16H11F4N5O/c17-10-3-1-2-9(11(10)18)16(4-5-16)23-15-21-6-8(7-22-15)13-24-25-14(26-13)12(19)20/h1-3,6-7,12H,4-5H2,(H,21,22,23)
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n/an/a 22n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408434
PNG
(N-(2-(4-(difluoromethoxy)-2-fluorophenyl)-2-((5-(5...)
Show SMILES FC(F)Oc1ccc(C(CNS(=O)(=O)C2CC2)Nc2ncc(cn2)-c2nnc(o2)C(F)F)c(F)c1
Show InChI InChI=1S/C19H17F5N6O4S/c20-13-5-10(33-18(23)24)1-4-12(13)14(8-27-35(31,32)11-2-3-11)28-19-25-6-9(7-26-19)16-29-30-17(34-16)15(21)22/h1,4-7,11,14-15,18,27H,2-3,8H2,(H,25,26,28)
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n/an/a 23n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408365
PNG
(US10357493, Example 80)
Show SMILES FC(F)c1nnc(o1)-c1cnc(NC2(CC2)c2cc(F)ccc2Cl)nc1
Show InChI InChI=1S/C16H11ClF3N5O/c17-11-2-1-9(18)5-10(11)16(3-4-16)23-15-21-6-8(7-22-15)13-24-25-14(26-13)12(19)20/h1-2,5-7,12H,3-4H2,(H,21,22,23)
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Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408336
PNG
(5-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)-N-(1-(...)
Show SMILES FC(F)c1nnc(o1)-c1cnc(NC2(CC2)c2cccc(OC(F)(F)F)c2)nc1
Show InChI InChI=1S/C17H12F5N5O2/c18-12(19)14-27-26-13(28-14)9-7-23-15(24-8-9)25-16(4-5-16)10-2-1-3-11(6-10)29-17(20,21)22/h1-3,6-8,12H,4-5H2,(H,23,24,25)
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Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408281
PNG
(5-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)-N-(1-p...)
Show SMILES FC(F)c1nnc(o1)-c1cnc(NC2(CC2)c2ccccc2)nc1
Show InChI InChI=1S/C16H13F2N5O/c17-12(18)14-23-22-13(24-14)10-8-19-15(20-9-10)21-16(6-7-16)11-4-2-1-3-5-11/h1-5,8-9,12H,6-7H2,(H,19,20,21)
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Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408329
PNG
(5-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)-N-(1-(...)
Show SMILES COc1ccccc1C1(CC1)Nc1ncc(cn1)-c1nnc(o1)C(F)F
Show InChI InChI=1S/C17H15F2N5O2/c1-25-12-5-3-2-4-11(12)17(6-7-17)22-16-20-8-10(9-21-16)14-23-24-15(26-14)13(18)19/h2-5,8-9,13H,6-7H2,1H3,(H,20,21,22)
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Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408469
PNG
(N-(2-(4-chlorophenyl)-2-((5-(5-(difluoromethyl)-1,...)
Show SMILES CS(=O)(=O)NC[C@H](Nc1ncc(cn1)-c1nnc(o1)C(F)F)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H15ClF2N6O3S/c1-29(26,27)22-8-12(9-2-4-11(17)5-3-9)23-16-20-6-10(7-21-16)14-24-25-15(28-14)13(18)19/h2-7,12-13,22H,8H2,1H3,(H,20,21,23)/t12-/m0/s1
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Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408410
PNG
(N-(3-((5-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)...)
Show SMILES CS(=O)(=O)NCCC(Nc1ncc(cn1)-c1nnc(o1)C(F)F)c1ccc(F)cc1
Show InChI InChI=1S/C17H17F3N6O3S/c1-30(27,28)23-7-6-13(10-2-4-12(18)5-3-10)24-17-21-8-11(9-22-17)15-25-26-16(29-15)14(19)20/h2-5,8-9,13-14,23H,6-7H2,1H3,(H,21,22,24)
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Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408391
PNG
(N-(2-((5-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)...)
Show SMILES CCS(=O)(=O)NCC(Nc1ncc(cn1)-c1nnc(o1)C(F)F)c1ccc(F)cc1
Show InChI InChI=1S/C17H17F3N6O3S/c1-2-30(27,28)23-9-13(10-3-5-12(18)6-4-10)24-17-21-7-11(8-22-17)15-25-26-16(29-15)14(19)20/h3-8,13-14,23H,2,9H2,1H3,(H,21,22,24)
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Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408330
PNG
(N-(1-(4-bromophenyl)cyclopropyl)-5-(5-(difluoromet...)
Show SMILES FC(F)c1nnc(o1)-c1cnc(NC2(CC2)c2ccc(Br)cc2)nc1
Show InChI InChI=1S/C16H12BrF2N5O/c17-11-3-1-10(2-4-11)16(5-6-16)22-15-20-7-9(8-21-15)13-23-24-14(25-13)12(18)19/h1-4,7-8,12H,5-6H2,(H,20,21,22)
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Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408393
PNG
(N-(2-((5-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)...)
Show SMILES FC(F)c1nnc(o1)-c1cnc(NC(CNS(=O)(=O)C2CC2)c2ccc(F)cc2)nc1
Show InChI InChI=1S/C18H17F3N6O3S/c19-12-3-1-10(2-4-12)14(9-24-31(28,29)13-5-6-13)25-18-22-7-11(8-23-18)16-26-27-17(30-16)15(20)21/h1-4,7-8,13-15,24H,5-6,9H2,(H,22,23,25)
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n/an/a 28n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408360
PNG
(N-(1-(2-chloro-3-methylphenyl)cyclopropyl)-5-(5-(d...)
Show SMILES Cc1cccc(c1Cl)C1(CC1)Nc1ncc(cn1)-c1nnc(o1)C(F)F
Show InChI InChI=1S/C17H14ClF2N5O/c1-9-3-2-4-11(12(9)18)17(5-6-17)23-16-21-7-10(8-22-16)14-24-25-15(26-14)13(19)20/h2-4,7-8,13H,5-6H2,1H3,(H,21,22,23)
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n/an/a 28n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408371
PNG
(US10357493, Example 86)
Show SMILES FC(F)Oc1cccc(c1Cl)C1(CC1)Nc1ncc(cn1)-c1nnc(o1)C(F)F
Show InChI InChI=1S/C17H12ClF4N5O2/c18-11-9(2-1-3-10(11)28-15(21)22)17(4-5-17)25-16-23-6-8(7-24-16)13-26-27-14(29-13)12(19)20/h1-3,6-7,12,15H,4-5H2,(H,23,24,25)
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n/an/a 28n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408347
PNG
(N-(1-(6-bromopyridin-3-yl)cyclopropyl)-5-(5-(diflu...)
Show SMILES FC(F)c1nnc(o1)-c1cnc(NC2(CC2)c2ccc(Br)nc2)nc1
Show InChI InChI=1S/C15H11BrF2N6O/c16-10-2-1-9(7-19-10)15(3-4-15)22-14-20-5-8(6-21-14)12-23-24-13(25-12)11(17)18/h1-2,5-7,11H,3-4H2,(H,20,21,22)
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n/an/a 28n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408381
PNG
(US10357493, Example 99-R)
Show SMILES C[C@@H](Nc1ncc(cn1)-c1nnc(o1)C(F)F)c1ccc(F)cc1F
Show InChI InChI=1S/C15H11F4N5O/c1-7(10-3-2-9(16)4-11(10)17)22-15-20-5-8(6-21-15)13-23-24-14(25-13)12(18)19/h2-7,12H,1H3,(H,20,21,22)/t7-/m1/s1
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n/an/a 28n/an/an/an/an/an/a



Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408319
PNG
(N-(2-((5-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)...)
Show SMILES CS(=O)(=O)NCC(Nc1ncc(cn1)-c1nnc(o1)C(F)F)c1ccc(F)cc1
Show InChI InChI=1S/C16H15F3N6O3S/c1-29(26,27)22-8-12(9-2-4-11(17)5-3-9)23-16-20-6-10(7-21-16)14-24-25-15(28-14)13(18)19/h2-7,12-13,22H,8H2,1H3,(H,20,21,23)
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Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408403
PNG
(N-(2-((5-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)...)
Show SMILES FC(F)c1nnc(o1)-c1cnc(N[C@@H](CNS(=O)(=O)CC(F)(F)F)c2ccc(F)cc2)nc1
Show InChI InChI=1S/C17H14F6N6O3S/c18-11-3-1-9(2-4-11)12(7-26-33(30,31)8-17(21,22)23)27-16-24-5-10(6-25-16)14-28-29-15(32-14)13(19)20/h1-6,12-13,26H,7-8H2,(H,24,25,27)/t12-/m0/s1
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Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408373
PNG
(US10357493, Example 88)
Show SMILES FC(F)c1nnc(o1)-c1cnc(NC2(CCC2)c2ccc(F)cc2)nc1
Show InChI InChI=1S/C17H14F3N5O/c18-12-4-2-11(3-5-12)17(6-1-7-17)23-16-21-8-10(9-22-16)14-24-25-15(26-14)13(19)20/h2-5,8-9,13H,1,6-7H2,(H,21,22,23)
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Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408314
PNG
(N-(1-(4-(difluoromethoxy)-2-fluorophenyl)cycloprop...)
Show SMILES FC(F)Oc1ccc(c(F)c1)C1(CC1)Nc1ncc(cn1)-c1nnc(o1)C(F)F
Show InChI InChI=1S/C17H12F5N5O2/c18-11-5-9(28-15(21)22)1-2-10(11)17(3-4-17)25-16-23-6-8(7-24-16)13-26-27-14(29-13)12(19)20/h1-2,5-7,12,15H,3-4H2,(H,23,24,25)
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Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408459
PNG
(N-(2-((5-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)...)
Show SMILES FC(F)c1nnc(o1)-c1cnc(N[C@@H](CNC(=O)C2CC2)c2ccc(F)cc2)nc1
Show InChI InChI=1S/C19H17F3N6O2/c20-13-5-3-10(4-6-13)14(9-23-16(29)11-1-2-11)26-19-24-7-12(8-25-19)17-27-28-18(30-17)15(21)22/h3-8,11,14-15H,1-2,9H2,(H,23,29)(H,24,25,26)/t14-/m0/s1
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Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408383
PNG
(US10357493, Example 100(+))
Show SMILES C[C@H](Nc1ncc(cn1)-c1nnc(o1)C(F)F)c1c(F)cccc1F
Show InChI InChI=1S/C15H11F4N5O/c1-7(11-9(16)3-2-4-10(11)17)22-15-20-5-8(6-21-15)13-23-24-14(25-13)12(18)19/h2-7,12H,1H3,(H,20,21,22)/t7-/m0/s1
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Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM408333
PNG
(N-(1-(4-chlorophenyl)cyclopropyl)-5-(5-(difluorome...)
Show SMILES FC(F)c1nnc(o1)-c1cnc(NC2(CC2)c2ccc(Cl)cc2)nc1
Show InChI InChI=1S/C16H12ClF2N5O/c17-11-3-1-10(2-4-11)16(5-6-16)22-15-20-7-9(8-21-15)13-23-24-14(25-13)12(18)19/h1-4,7-8,12H,5-6H2,(H,20,21,22)
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Selenity Therapeutics (Bermuda), Ltd.

US Patent


Assay Description
All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...


US Patent US10357493 (2019)


BindingDB Entry DOI: 10.7270/Q2377C3H
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%