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Patent code US10358416

Compile Data Set for Download or QSAR

Found 288 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM404212
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(2'-cyano-4'-methoxy-...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)C1CCN(CC1)c1ccc(cc1[N+]([O-])=O)S(=O)(=O)N1CCCCC1)c1ccccc1Cl
Show InChI InChI=1S/C28H33ClN4O7S/c29-22-7-3-2-6-21(22)23-10-11-25(28(35)36)32(23)27(34)19-12-16-30(17-13-19)24-9-8-20(18-26(24)33(37)38)41(39,40)31-14-4-1-5-15-31/h2-3,6-9,18-19,23,25H,1,4-5,10-17H2,(H,35,36)/t23-,25+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM408766
PNG
((2S,5R)-1-(1-(5-chloro-2-nitrophenyl)piperidine-4-...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)C1CCN(CC1)c1cc(Cl)ccc1[N+]([O-])=O)c1ccccc1Cl
Show InChI InChI=1S/C23H23Cl2N3O5/c24-15-5-6-19(28(32)33)21(13-15)26-11-9-14(10-12-26)22(29)27-18(7-8-20(27)23(30)31)16-3-1-2-4-17(16)25/h1-6,13-14,18,20H,7-12H2,(H,30,31)/t18-,20+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM408762
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(1-(2-cyano-4-nitroph...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)C1CCN(CC1)c1ccc(cc1C#N)[N+]([O-])=O)c1ccccc1Cl
Show InChI InChI=1S/C24H23ClN4O5/c25-19-4-2-1-3-18(19)21-7-8-22(24(31)32)28(21)23(30)15-9-11-27(12-10-15)20-6-5-17(29(33)34)13-16(20)14-26/h1-6,13,15,21-22H,7-12H2,(H,31,32)/t21-,22+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM408761
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(1-(4-methyl-2-nitrop...)
Show SMILES Cc1ccc(N2CCC(CC2)C(=O)N2[C@@H](CC[C@@H]2c2ccccc2Cl)C(O)=O)c(c1)[N+]([O-])=O
Show InChI InChI=1S/C24H26ClN3O5/c1-15-6-7-20(22(14-15)28(32)33)26-12-10-16(11-13-26)23(29)27-19(8-9-21(27)24(30)31)17-4-2-3-5-18(17)25/h2-7,14,16,19,21H,8-13H2,1H3,(H,30,31)/t19-,21+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM404212
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(2'-cyano-4'-methoxy-...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)C1CCN(CC1)c1ccc(cc1[N+]([O-])=O)S(=O)(=O)N1CCCCC1)c1ccccc1Cl
Show InChI InChI=1S/C28H33ClN4O7S/c29-22-7-3-2-6-21(22)23-10-11-25(28(35)36)32(23)27(34)19-12-16-30(17-13-19)24-9-8-20(18-26(24)33(37)38)41(39,40)31-14-4-1-5-15-31/h2-3,6-9,18-19,23,25H,1,4-5,10-17H2,(H,35,36)/t23-,25+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM408758
PNG
( (2S,5R)-5-(2-chlorophenyl)-1-(1-(4-(morpholinosul...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)C1CCN(CC1)c1ccc(cc1[N+]([O-])=O)S(=O)(=O)N1CCOCC1)c1ccccc1Cl
Show InChI InChI=1S/C27H31ClN4O8S/c28-21-4-2-1-3-20(21)22-7-8-24(27(34)35)31(22)26(33)18-9-11-29(12-10-18)23-6-5-19(17-25(23)32(36)37)41(38,39)30-13-15-40-16-14-30/h1-6,17-18,22,24H,7-16H2,(H,34,35)/t22-,24+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM408760
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(1-(4-(N,N-diethylsul...)
Show SMILES CCN(CC)S(=O)(=O)c1ccc(N2CCC(CC2)C(=O)N2[C@@H](CC[C@@H]2c2ccccc2Cl)C(O)=O)c(c1)[N+]([O-])=O
Show InChI InChI=1S/C27H33ClN4O7S/c1-3-30(4-2)40(38,39)19-9-10-23(25(17-19)32(36)37)29-15-13-18(14-16-29)26(33)31-22(11-12-24(31)27(34)35)20-7-5-6-8-21(20)28/h5-10,17-18,22,24H,3-4,11-16H2,1-2H3,(H,34,35)/t22-,24+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM408767
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(1-(2-nitrophenyl)pip...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)C1CCN(CC1)c1ccccc1[N+]([O-])=O)c1ccccc1Cl
Show InChI InChI=1S/C23H24ClN3O5/c24-17-6-2-1-5-16(17)18-9-10-21(23(29)30)26(18)22(28)15-11-13-25(14-12-15)19-7-3-4-8-20(19)27(31)32/h1-8,15,18,21H,9-14H2,(H,29,30)/t18-,21+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM408764
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(1-(2-fluoro-4-nitrop...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)C1CCN(CC1)c1ccc(cc1F)[N+]([O-])=O)c1ccccc1Cl
Show InChI InChI=1S/C23H23ClFN3O5/c24-17-4-2-1-3-16(17)19-7-8-21(23(30)31)27(19)22(29)14-9-11-26(12-10-14)20-6-5-15(28(32)33)13-18(20)25/h1-6,13-14,19,21H,7-12H2,(H,30,31)/t19-,21+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM408763
PNG
( (2S,5R)-5-(2-chlorophenyl)-1-(1-(4-nitrophenyl)pi...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)C1CCN(CC1)c1ccc(cc1)[N+]([O-])=O)c1ccccc1Cl
Show InChI InChI=1S/C23H24ClN3O5/c24-19-4-2-1-3-18(19)20-9-10-21(23(29)30)26(20)22(28)15-11-13-25(14-12-15)16-5-7-17(8-6-16)27(31)32/h1-8,15,20-21H,9-14H2,(H,29,30)/t20-,21+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM408765
PNG
( (2S,5R)-5-(2-chlorophenyl)-1-(1-(3-methoxy-4-nitr...)
Show SMILES COc1cc(ccc1[N+]([O-])=O)N1CCC(CC1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C24H26ClN3O6/c1-34-22-14-16(6-7-20(22)28(32)33)26-12-10-15(11-13-26)23(29)27-19(8-9-21(27)24(30)31)17-4-2-3-5-18(17)25/h2-7,14-15,19,21H,8-13H2,1H3,(H,30,31)/t19-,21+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403787
PNG
((2S,5R)-1-([1,1'-biphenyl]-4-carbonyl)-5-(2-chloro...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)c1ccc(cc1)-c1ccccc1)c1ccccc1Cl
Show InChI InChI=1S/C24H20ClNO3/c25-20-9-5-4-8-19(20)21-14-15-22(24(28)29)26(21)23(27)18-12-10-17(11-13-18)16-6-2-1-3-7-16/h1-13,21-22H,14-15H2,(H,28,29)/t21-,22+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403801
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(3-phenethoxybenzoyl)...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)c1cccc(OCCc2ccccc2)c1)c1ccccc1Cl
Show InChI InChI=1S/C26H24ClNO4/c27-22-12-5-4-11-21(22)23-13-14-24(26(30)31)28(23)25(29)19-9-6-10-20(17-19)32-16-15-18-7-2-1-3-8-18/h1-12,17,23-24H,13-16H2,(H,30,31)/t23-,24+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403810
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(4-isopropoxybenzoyl)...)
Show SMILES CC(C)Oc1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C21H22ClNO4/c1-13(2)27-15-9-7-14(8-10-15)20(24)23-18(11-12-19(23)21(25)26)16-5-3-4-6-17(16)22/h3-10,13,18-19H,11-12H2,1-2H3,(H,25,26)/t18-,19+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403840
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(4-((p-tolyloxy)methy...)
Show SMILES Cc1ccc(OCc2ccc(cc2)C(=O)N2[C@@H](CC[C@@H]2c2ccccc2Cl)C(O)=O)cc1
Show InChI InChI=1S/C26H24ClNO4/c1-17-6-12-20(13-7-17)32-16-18-8-10-19(11-9-18)25(29)28-23(14-15-24(28)26(30)31)21-4-2-3-5-22(21)27/h2-13,23-24H,14-16H2,1H3,(H,30,31)/t23-,24+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403854
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(4-(pyrimidin-5-yl)be...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)c1ccc(cc1)-c1cncnc1)c1ccccc1Cl
Show InChI InChI=1S/C22H18ClN3O3/c23-18-4-2-1-3-17(18)19-9-10-20(22(28)29)26(19)21(27)15-7-5-14(6-8-15)16-11-24-13-25-12-16/h1-8,11-13,19-20H,9-10H2,(H,28,29)/t19-,20+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403855
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(4-(6-methoxypyridin-...)
Show SMILES COc1ccc(cn1)-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C24H21ClN2O4/c1-31-22-13-10-17(14-26-22)15-6-8-16(9-7-15)23(28)27-20(11-12-21(27)24(29)30)18-4-2-3-5-19(18)25/h2-10,13-14,20-21H,11-12H2,1H3,(H,29,30)/t20-,21+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403865
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(4-(2-methoxypyridin-...)
Show SMILES COc1ncccc1-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C24H21ClN2O4/c1-31-22-17(6-4-14-26-22)15-8-10-16(11-9-15)23(28)27-20(12-13-21(27)24(29)30)18-5-2-3-7-19(18)25/h2-11,14,20-21H,12-13H2,1H3,(H,29,30)/t20-,21+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403867
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(4-(4-methoxypyridin-...)
Show SMILES COc1ccncc1-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C24H21ClN2O4/c1-31-22-12-13-26-14-18(22)15-6-8-16(9-7-15)23(28)27-20(10-11-21(27)24(29)30)17-4-2-3-5-19(17)25/h2-9,12-14,20-21H,10-11H2,1H3,(H,29,30)/t20-,21+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403878
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(4'-(methylsulfonamid...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C25H23ClN2O5S/c1-34(32,33)27-19-12-10-17(11-13-19)16-6-8-18(9-7-16)24(29)28-22(14-15-23(28)25(30)31)20-4-2-3-5-21(20)26/h2-13,22-23,27H,14-15H2,1H3,(H,30,31)/t22-,23+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403881
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(4-(naphthalen-2-yl)b...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)c1ccc(cc1)-c1ccc2ccccc2c1)c1ccccc1Cl
Show InChI InChI=1S/C28H22ClNO3/c29-24-8-4-3-7-23(24)25-15-16-26(28(32)33)30(25)27(31)20-12-9-19(10-13-20)22-14-11-18-5-1-2-6-21(18)17-22/h1-14,17,25-26H,15-16H2,(H,32,33)/t25-,26+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403884
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(2'-(trifluoromethoxy...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)c1ccc(cc1)-c1ccccc1OC(F)(F)F)c1ccccc1Cl
Show InChI InChI=1S/C25H19ClF3NO4/c26-19-7-3-1-6-18(19)20-13-14-21(24(32)33)30(20)23(31)16-11-9-15(10-12-16)17-5-2-4-8-22(17)34-25(27,28)29/h1-12,20-21H,13-14H2,(H,32,33)/t20-,21+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403906
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(4-phenoxybenzoyl)pyr...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)c1ccc(Oc2ccccc2)cc1)c1ccccc1Cl
Show InChI InChI=1S/C24H20ClNO4/c25-20-9-5-4-8-19(20)21-14-15-22(24(28)29)26(21)23(27)16-10-12-18(13-11-16)30-17-6-2-1-3-7-17/h1-13,21-22H,14-15H2,(H,28,29)/t21-,22+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403911
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(4-methylpentanoyl)py...)
Show SMILES CC(C)CCC(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C17H22ClNO3/c1-11(2)7-10-16(20)19-14(8-9-15(19)17(21)22)12-5-3-4-6-13(12)18/h3-6,11,14-15H,7-10H2,1-2H3,(H,21,22)/t14-,15+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403912
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(3-methyl-4-morpholin...)
Show SMILES Cc1cc(ccc1N1CCOCC1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C23H25ClN2O4/c1-15-14-16(6-7-19(15)25-10-12-30-13-11-25)22(27)26-20(8-9-21(26)23(28)29)17-4-2-3-5-18(17)24/h2-7,14,20-21H,8-13H2,1H3,(H,28,29)/t20-,21+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403937
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(2'-(trifluoromethyl)...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)c1ccc(cc1)-c1ccccc1C(F)(F)F)c1ccccc1Cl
Show InChI InChI=1S/C25H19ClF3NO3/c26-20-8-4-2-6-18(20)21-13-14-22(24(32)33)30(21)23(31)16-11-9-15(10-12-16)17-5-1-3-7-19(17)25(27,28)29/h1-12,21-22H,13-14H2,(H,32,33)/t21-,22+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403938
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(2,2'-dimethoxy-[1,1'...)
Show SMILES COc1ccccc1-c1ccc(cc1OC)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C26H24ClNO5/c1-32-23-10-6-4-7-17(23)18-12-11-16(15-24(18)33-2)25(29)28-21(13-14-22(28)26(30)31)19-8-3-5-9-20(19)27/h3-12,15,21-22H,13-14H2,1-2H3,(H,30,31)/t21-,22+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403945
PNG
((2S,5R)-1-(2-chloro-[1,1'-biphenyl]-4-carbonyl)-5-...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)c1ccc(c(Cl)c1)-c1ccccc1)c1ccccc1Cl
Show InChI InChI=1S/C24H19Cl2NO3/c25-19-9-5-4-8-18(19)21-12-13-22(24(29)30)27(21)23(28)16-10-11-17(20(26)14-16)15-6-2-1-3-7-15/h1-11,14,21-22H,12-13H2,(H,29,30)/t21-,22+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403949
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(4-(2-methylthiophen-...)
Show SMILES Cc1sccc1-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C23H20ClNO3S/c1-14-17(12-13-29-14)15-6-8-16(9-7-15)22(26)25-20(10-11-21(25)23(27)28)18-4-2-3-5-19(18)24/h2-9,12-13,20-21H,10-11H2,1H3,(H,27,28)/t20-,21+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403987
PNG
((2S,5R)-1-(4-(2,4-dimethoxypyrimidin-5-yl)benzoyl)...)
Show SMILES COc1ncc(c(OC)n1)-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1F)C(O)=O
Show InChI InChI=1S/C24H22FN3O5/c1-32-21-17(13-26-24(27-21)33-2)14-7-9-15(10-8-14)22(29)28-19(11-12-20(28)23(30)31)16-5-3-4-6-18(16)25/h3-10,13,19-20H,11-12H2,1-2H3,(H,30,31)/t19-,20+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403992
PNG
((2S,5R)-1-(2'-methoxy-[1,1'-biphenyl]-4-carbonyl)-...)
Show SMILES COc1ccccc1-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1)C(O)=O
Show InChI InChI=1S/C25H23NO4/c1-30-23-10-6-5-9-20(23)17-11-13-19(14-12-17)24(27)26-21(15-16-22(26)25(28)29)18-7-3-2-4-8-18/h2-14,21-22H,15-16H2,1H3,(H,28,29)/t21-,22+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403995
PNG
((2S,5R)-5-(3-chlorophenyl)-1-(2'-methoxy-[1,1'-bip...)
Show SMILES COc1ccccc1-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1cccc(Cl)c1)C(O)=O
Show InChI InChI=1S/C25H22ClNO4/c1-31-23-8-3-2-7-20(23)16-9-11-17(12-10-16)24(28)27-21(13-14-22(27)25(29)30)18-5-4-6-19(26)15-18/h2-12,15,21-22H,13-14H2,1H3,(H,29,30)/t21-,22+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403997
PNG
((2S,5R)-5-(3-fluorophenyl)-1-(2'-methoxy-[1,1'-bip...)
Show SMILES COc1ccccc1-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1cccc(F)c1)C(O)=O
Show InChI InChI=1S/C25H22FNO4/c1-31-23-8-3-2-7-20(23)16-9-11-17(12-10-16)24(28)27-21(13-14-22(27)25(29)30)18-5-4-6-19(26)15-18/h2-12,15,21-22H,13-14H2,1H3,(H,29,30)/t21-,22+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM404054
PNG
((2S,5R)-1-(4-(2-chloro-4-methoxypyrimidin-5-yl)ben...)
Show SMILES COc1nc(Cl)ncc1-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C23H19Cl2N3O4/c1-32-20-16(12-26-23(25)27-20)13-6-8-14(9-7-13)21(29)28-18(10-11-19(28)22(30)31)15-4-2-3-5-17(15)24/h2-9,12,18-19H,10-11H2,1H3,(H,30,31)/t18-,19+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM404100
PNG
((2S,5R)-1-(3-chloro-4-(pyrimidin-4-yl)benzoyl)-5-(...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)c1ccc(c(Cl)c1)-c1ccncn1)c1ccccc1Cl
Show InChI InChI=1S/C22H17Cl2N3O3/c23-16-4-2-1-3-15(16)19-7-8-20(22(29)30)27(19)21(28)13-5-6-14(17(24)11-13)18-9-10-25-12-26-18/h1-6,9-12,19-20H,7-8H2,(H,29,30)/t19-,20+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM404108
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(4-(6-ethoxypyridin-3...)
Show SMILES CCOc1ccc(cn1)-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C25H23ClN2O4/c1-2-32-23-14-11-18(15-27-23)16-7-9-17(10-8-16)24(29)28-21(12-13-22(28)25(30)31)19-5-3-4-6-20(19)26/h3-11,14-15,21-22H,2,12-13H2,1H3,(H,30,31)/t21-,22+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM404135
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(2'-isopropyl-[1,1'-b...)
Show SMILES CC(C)c1ccccc1-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C27H26ClNO3/c1-17(2)20-7-3-4-8-21(20)18-11-13-19(14-12-18)26(30)29-24(15-16-25(29)27(31)32)22-9-5-6-10-23(22)28/h3-14,17,24-25H,15-16H2,1-2H3,(H,31,32)/t24-,25+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM404169
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(1-(2-methoxyphenyl)p...)
Show SMILES COc1ccccc1N1CCC(CC1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C24H27ClN2O4/c1-31-22-9-5-4-8-20(22)26-14-12-16(13-15-26)23(28)27-19(10-11-21(27)24(29)30)17-6-2-3-7-18(17)25/h2-9,16,19,21H,10-15H2,1H3,(H,29,30)/t19-,21+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM404180
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(5'-cyano-2'-methyl-[...)
Show SMILES Cc1ccc(cc1-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O)C#N
Show InChI InChI=1S/C26H21ClN2O3/c1-16-6-7-17(15-28)14-21(16)18-8-10-19(11-9-18)25(30)29-23(12-13-24(29)26(31)32)20-4-2-3-5-22(20)27/h2-11,14,23-24H,12-13H2,1H3,(H,31,32)/t23-,24+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM404181
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(4-(4,6-dimethoxypyri...)
Show SMILES COc1cc(OC)c(cn1)-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C25H23ClN2O5/c1-32-22-13-23(33-2)27-14-18(22)15-7-9-16(10-8-15)24(29)28-20(11-12-21(28)25(30)31)17-5-3-4-6-19(17)26/h3-10,13-14,20-21H,11-12H2,1-2H3,(H,30,31)/t20-,21+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM404204
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(1-(2-cyano-4-(triflu...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)C1CCN(CC1)c1ccc(cc1C#N)C(F)(F)F)c1ccccc1Cl
Show InChI InChI=1S/C25H23ClF3N3O3/c26-19-4-2-1-3-18(19)21-7-8-22(24(34)35)32(21)23(33)15-9-11-31(12-10-15)20-6-5-17(25(27,28)29)13-16(20)14-30/h1-6,13,15,21-22H,7-12H2,(H,34,35)/t21-,22+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM404229
PNG
((2S,5R)-5-(2,5-difluorophenyl)-1-(2'-methoxy-[1,1'...)
Show SMILES COc1ccccc1-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1cc(F)ccc1F)C(O)=O
Show InChI InChI=1S/C25H21F2NO4/c1-32-23-5-3-2-4-18(23)15-6-8-16(9-7-15)24(29)28-21(12-13-22(28)25(30)31)19-14-17(26)10-11-20(19)27/h2-11,14,21-22H,12-13H2,1H3,(H,30,31)/t21-,22+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM404235
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(3'-cyano-4'-fluoro-[...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)c1ccc(cc1)-c1ccc(F)c(c1)C#N)c1ccccc1Cl
Show InChI InChI=1S/C25H18ClFN2O3/c26-20-4-2-1-3-19(20)22-11-12-23(25(31)32)29(22)24(30)16-7-5-15(6-8-16)17-9-10-21(27)18(13-17)14-28/h1-10,13,22-23H,11-12H2,(H,31,32)/t22-,23+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403792
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(3'-methoxy-[1,1'-bip...)
Show SMILES COc1cccc(c1)-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C25H22ClNO4/c1-31-19-6-4-5-18(15-19)16-9-11-17(12-10-16)24(28)27-22(13-14-23(27)25(29)30)20-7-2-3-8-21(20)26/h2-12,15,22-23H,13-14H2,1H3,(H,29,30)/t22-,23+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403836
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(2-(2-chlorophenyl)py...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)c1cnc(nc1)-c1ccccc1Cl)c1ccccc1Cl
Show InChI InChI=1S/C22H17Cl2N3O3/c23-16-7-3-1-5-14(16)18-9-10-19(22(29)30)27(18)21(28)13-11-25-20(26-12-13)15-6-2-4-8-17(15)24/h1-8,11-12,18-19H,9-10H2,(H,29,30)/t18-,19+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403844
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(4-(5-(p-tolyl)-1H-1,...)
Show SMILES Cc1ccc(cc1)-c1cnnn1-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C27H23ClN4O3/c1-17-6-8-18(9-7-17)25-16-29-30-32(25)20-12-10-19(11-13-20)26(33)31-23(14-15-24(31)27(34)35)21-4-2-3-5-22(21)28/h2-13,16,23-24H,14-15H2,1H3,(H,34,35)/t23-,24+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403853
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(2',5'-dichloro-[1,1'...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)c1ccc(cc1)-c1cc(Cl)ccc1Cl)c1ccccc1Cl
Show InChI InChI=1S/C24H18Cl3NO3/c25-16-9-10-20(27)18(13-16)14-5-7-15(8-6-14)23(29)28-21(11-12-22(28)24(30)31)17-3-1-2-4-19(17)26/h1-10,13,21-22H,11-12H2,(H,30,31)/t21-,22+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403879
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(3'-(methylsulfonamid...)
Show SMILES CS(=O)(=O)Nc1cccc(c1)-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C25H23ClN2O5S/c1-34(32,33)27-19-6-4-5-18(15-19)16-9-11-17(12-10-16)24(29)28-22(13-14-23(28)25(30)31)20-7-2-3-8-21(20)26/h2-12,15,22-23,27H,13-14H2,1H3,(H,30,31)/t22-,23+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403880
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(2'-(methylsulfonamid...)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1ccc(cc1)C(=O)N1[C@@H](CC[C@@H]1c1ccccc1Cl)C(O)=O
Show InChI InChI=1S/C25H23ClN2O5S/c1-34(32,33)27-21-9-5-3-6-18(21)16-10-12-17(13-11-16)24(29)28-22(14-15-23(28)25(30)31)19-7-2-4-8-20(19)26/h2-13,22-23,27H,14-15H2,1H3,(H,30,31)/t22-,23+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))
BDBM403888
PNG
((2S,5R)-5-(2-chlorophenyl)-1-(2'-phenoxy-[1,1'-bip...)
Show SMILES OC(=O)[C@@H]1CC[C@@H](N1C(=O)c1ccc(cc1)-c1ccccc1Oc1ccccc1)c1ccccc1Cl
Show InChI InChI=1S/C30H24ClNO4/c31-25-12-6-4-11-24(25)26-18-19-27(30(34)35)32(26)29(33)21-16-14-20(15-17-21)23-10-5-7-13-28(23)36-22-8-2-1-3-9-22/h1-17,26-27H,18-19H2,(H,34,35)/t26-,27+/m1/s1
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Epics Therapeutics

US Patent


Assay Description
The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membra...


US Patent US10358416 (2019)


BindingDB Entry DOI: 10.7270/Q2TT4T9T
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%