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Patent code US10358435

Compile Data Set for Download or QSAR
Found 116 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408573
PNG
(US10358435, Example 89 | US10358435, Example 90)
Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)-c2nnn3c2CCC[C@@]3(C)c2ccc(cc2F)C(F)(F)F)cc1
PDB

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0.400n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408558
PNG
(US10358435, Example 74 | US10358435, Example 75)
Show SMILES C[C@H](c1cn(nn1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1Cl)C(F)(F)F
PDB

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0.420n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408512
PNG
(US10358435, Example 29)
Show SMILES CC(N=[N+]=[N-])c1ccc(cc1Cl)C(F)(F)F
Show InChI InChI=1S/C9H7ClF3N3/c1-5(15-16-14)7-3-2-6(4-8(7)10)9(11,12)13/h2-5H,1H3
PDB

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0.530n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408575
PNG
((S)- or (R)-6-(7-(2-Fluoro-4- (trifluoromethyl)phe...)
Show SMILES COc1cccc(Cc2nc(cc(=O)[nH]2)-c2nnn3c2CCCC3(C)c2ccc(cc2F)C(F)(F)F)c1
PDB

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0.560n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM408512
PNG
(US10358435, Example 29)
Show SMILES CC(N=[N+]=[N-])c1ccc(cc1Cl)C(F)(F)F
Show InChI InChI=1S/C9H7ClF3N3/c1-5(15-16-14)7-3-2-6(4-8(7)10)9(11,12)13/h2-5H,1H3
PDB

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US Patent
0.630n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM408573
PNG
(US10358435, Example 89 | US10358435, Example 90)
Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)-c2nnn3c2CCC[C@@]3(C)c2ccc(cc2F)C(F)(F)F)cc1
PDB

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0.630n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408564
PNG
(US10358435, Example 80 | US10358435, Example 81)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1nnc2n1CCC[C@@]2(C)c1ccc(cc1F)C(F)(F)F
PDB

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0.930n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408571
PNG
(US10358435, Example 87 | US10358435, Example 88)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1nnn2c1CCC[C@@]2(C)c1ccc(cc1Cl)C(F)(F)F
PDB

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1.20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408542
PNG
((R)- or (S)-6-(7-(2-fluoro-4- (trifluoromethyl)phe...)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1nnn2c1COCC2(C)c1ccc(cc1F)C(F)(F)F
PDB

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1.30n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM408582
PNG
((R)- or (S)-6-(6-(2-Fluoro-4- (trifluoromethyl)phe...)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1nnn2c1CCC2(C)c1ccc(cc1F)C(F)(F)F
PDB

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1.30n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408582
PNG
((R)- or (S)-6-(6-(2-Fluoro-4- (trifluoromethyl)phe...)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1nnn2c1CCC2(C)c1ccc(cc1F)C(F)(F)F
PDB

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1.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408515
PNG
(6-(1-(2-(2-chloro-4-ethylphenyl) propan-2-yl)-1H-1...)
Show SMILES CCc1ccc(c(Cl)c1)C(C)(C)n1cc(nn1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C18H20ClN5O/c1-5-12-6-7-13(14(19)8-12)18(3,4)24-10-16(22-23-24)15-9-17(25)21-11(2)20-15/h6-10H,5H2,1-4H3,(H,20,21,25)
PDB

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1.60n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408513
PNG
(6-(1-(2-(2-chloro-4-(trifluoromethyl) phenyl)propa...)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1cn(nn1)C(C)(C)c1ccc(cc1Cl)C(C)(C)C
Show InChI InChI=1S/C20H24ClN5O/c1-12-22-16(10-18(27)23-12)17-11-26(25-24-17)20(5,6)14-8-7-13(9-15(14)21)19(2,3)4/h7-11H,1-6H3,(H,22,23,27)
PDB

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1.70n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408518
PNG
(US10358435, Example 35 | US10358435, Example 36)
Show SMILES C[C@H](c1ccc(cc1Cl)C(F)(F)F)n1cc(nn1)-c1cc(=O)[nH]c(C)n1
PDB

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1.70n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM408564
PNG
(US10358435, Example 80 | US10358435, Example 81)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1nnc2n1CCC[C@@]2(C)c1ccc(cc1F)C(F)(F)F
PDB

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1.70n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM408571
PNG
(US10358435, Example 87 | US10358435, Example 88)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1nnn2c1CCC[C@@]2(C)c1ccc(cc1Cl)C(F)(F)F
PDB

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1.80n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408580
PNG
(US10358435, Example 95 | US10358435, Example 96)
Show SMILES CCc1ccc(c(F)c1)[C@@]1(C)CCCc2c(nnn12)-c1cc(=O)[nH]c(C)n1
PDB

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1.80n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408498
PNG
(US10358435, Example 19 | cyclopropyl(2-fluoro-4- (...)
Show SMILES OC(C1CC1)c1ccc(cc1F)C(F)(F)F
Show InChI InChI=1S/C11H10F4O/c12-9-5-7(11(13,14)15)3-4-8(9)10(16)6-1-2-6/h3-6,10,16H,1-2H2
PDB

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2.10n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM408515
PNG
(6-(1-(2-(2-chloro-4-ethylphenyl) propan-2-yl)-1H-1...)
Show SMILES CCc1ccc(c(Cl)c1)C(C)(C)n1cc(nn1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C18H20ClN5O/c1-5-12-6-7-13(14(19)8-12)18(3,4)24-10-16(22-23-24)15-9-17(25)21-11(2)20-15/h6-10H,5H2,1-4H3,(H,20,21,25)
PDB

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2.10n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408500
PNG
((R)- or (S)-6-(1-(1-(2,3-difluoro- 4-(trifluoromet...)
Show SMILES CCc1ccc(C(C)n2cc(nn2)-c2cc(=O)[nH]c(C)n2)c(F)c1F
PDB

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2.60n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408509
PNG
(1-(2-azidopropan-2-yl)-4- ethyl-2-methylbenzene | ...)
Show SMILES CCc1ccc(c(C)c1)C(C)(C)N=[N+]=[N-]
Show InChI InChI=1S/C12H17N3/c1-5-10-6-7-11(9(2)8-10)12(3,4)14-15-13/h6-8H,5H2,1-4H3
PDB

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3.20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM408498
PNG
(US10358435, Example 19 | cyclopropyl(2-fluoro-4- (...)
Show SMILES OC(C1CC1)c1ccc(cc1F)C(F)(F)F
Show InChI InChI=1S/C11H10F4O/c12-9-5-7(11(13,14)15)3-4-8(9)10(16)6-1-2-6/h3-6,10,16H,1-2H2
PDB

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3.40n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM408500
PNG
((R)- or (S)-6-(1-(1-(2,3-difluoro- 4-(trifluoromet...)
Show SMILES CCc1ccc(C(C)n2cc(nn2)-c2cc(=O)[nH]c(C)n2)c(F)c1F
PDB

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3.90n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408566
PNG
(US10358435, Example 82 | US10358435, Example 83)
Show SMILES C[C@H](c1cnn(n1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1Cl)C(F)(F)F
PDB

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4.20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408527
PNG
(US10358435, Example 43 | US10358435, Example 44)
Show SMILES C[C@@H](c1ccc(cc1Cl)C(F)(F)F)n1nnc(c1C)-c1cc(=O)[nH]c(C)n1
PDB

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4.60n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408494
PNG
((E)-2-(but-1-enyl)-6-(1-(1-(2-fluoro- 4-(trifluoro...)
Show SMILES CC\C=C\c1nc(cc(=O)[nH]1)-c1cn(nn1)C(C)c1ccc(cc1F)C(F)(F)F
PDB

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4.70n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408517
PNG
(6-(1-(2-(2-chloro-4-cyclopropylphenyl) propan-2-yl...)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1cn(nn1)C(C)(C)c1ccc(cc1Cl)C1CC1
Show InChI InChI=1S/C19H20ClN5O/c1-11-21-16(9-18(26)22-11)17-10-25(24-23-17)19(2,3)14-7-6-13(8-15(14)20)12-4-5-12/h6-10,12H,4-5H2,1-3H3,(H,21,22,26)
PDB

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4.90n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408514
PNG
(2-methyl-6-(1-(2-(2-methyl-4- (trifluoromethyl)phe...)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1cn(nn1)C(C)(C)c1ccc(cc1C)C(F)(F)F
Show InChI InChI=1S/C18H18F3N5O/c1-10-7-12(18(19,20)21)5-6-13(10)17(3,4)26-9-15(24-25-26)14-8-16(27)23-11(2)22-14/h5-9H,1-4H3,(H,22,23,27)
PDB

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5.40n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM408494
PNG
((E)-2-(but-1-enyl)-6-(1-(1-(2-fluoro- 4-(trifluoro...)
Show SMILES CC\C=C\c1nc(cc(=O)[nH]1)-c1cn(nn1)C(C)c1ccc(cc1F)C(F)(F)F
PDB

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6.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408488
PNG
(US10358435, Example 9)
Show SMILES C[C@@H](c1ccc(cc1C)C(F)(F)F)n1cc(nn1)-c1cc(=O)[nH]c(C)n1
PDB

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6.90n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408511
PNG
(1-(1-azidocyclobutyl-2- chloro-4-(trifluoromethyl)...)
Show SMILES FC(F)(F)c1ccc(c(Cl)c1)C1(CCC1)N=[N+]=[N-]
Show InChI InChI=1S/C11H9ClF3N3/c12-9-6-7(11(13,14)15)2-3-8(9)10(17-18-16)4-1-5-10/h2-3,6H,1,4-5H2
PDB

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7n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408523
PNG
((R)- or (S)-6-(1-(1-(2-fluoro-4- (trifluoromethyl)...)
Show SMILES CC(C)C(c1ccc(cc1F)C(F)(F)F)n1cc(nn1)-c1cc(=O)[nH]c(C)n1
PDB

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7.20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408551
PNG
((R)- or (S)-6-(5-(1-(2- chloro-4-(trifluoromethyl)...)
Show SMILES CC(c1nnc(-c2cc(=O)[nH]c(C)n2)n1C)c1ccc(cc1Cl)C(F)(F)F
PDB

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7.70n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408562
PNG
(US10358435, Example 78 | US10358435, Example 79)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1nnn2c1CCC[C@@]2(C)c1ccc(cc1C)C(F)(F)F
PDB

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8.30n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408491
PNG
(1-(1-azidoethyl)-4- (trifluoromethyl)benzene | US1...)
Show SMILES CC(N=[N+]=[N-])c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C9H8F3N3/c1-6(14-15-13)7-2-4-8(5-3-7)9(10,11)12/h2-6H,1H3
PDB

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8.40n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408558
PNG
(US10358435, Example 74 | US10358435, Example 75)
Show SMILES C[C@H](c1cn(nn1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1Cl)C(F)(F)F
PDB

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8.90n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM408491
PNG
(1-(1-azidoethyl)-4- (trifluoromethyl)benzene | US1...)
Show SMILES CC(N=[N+]=[N-])c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C9H8F3N3/c1-6(14-15-13)7-2-4-8(5-3-7)9(10,11)12/h2-6H,1H3
PDB

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8.90n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM408511
PNG
(1-(1-azidocyclobutyl-2- chloro-4-(trifluoromethyl)...)
Show SMILES FC(F)(F)c1ccc(c(Cl)c1)C1(CCC1)N=[N+]=[N-]
Show InChI InChI=1S/C11H9ClF3N3/c12-9-6-7(11(13,14)15)2-3-8(9)10(17-18-16)4-1-5-10/h2-3,6H,1,4-5H2
PDB

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9n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408529
PNG
((R)- or (S)-6-(5-butyl-1- (1-(2-chloro-4-(trifluor...)
Show SMILES CCCCc1c(nnn1C(C)c1ccc(cc1Cl)C(F)(F)F)-c1cc(=O)[nH]c(C)n1
PDB

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9.20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM408488
PNG
(US10358435, Example 9)
Show SMILES C[C@@H](c1ccc(cc1C)C(F)(F)F)n1cc(nn1)-c1cc(=O)[nH]c(C)n1
PDB

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9.40n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408525
PNG
(US10358435, Example 41 | US10358435, Example 42)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1cn(nn1)C(C1CC1)c1ccc(cc1F)C(F)(F)F
PDB

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9.70n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408521
PNG
((R)- or (S)-6-(1-(1-(2-fluoro-4- (trifluoromethyl)...)
Show SMILES CCC(c1ccc(cc1F)C(F)(F)F)n1cc(nn1)-c1cc(=O)[nH]c(C)n1
PDB

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10.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408521
PNG
((R)- or (S)-6-(1-(1-(2-fluoro-4- (trifluoromethyl)...)
Show SMILES CCC(c1ccc(cc1F)C(F)(F)F)n1cc(nn1)-c1cc(=O)[nH]c(C)n1
PDB

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11n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408549
PNG
((R)- or (S)-6-(5-(1-(2- chloro-4-(trifluoromethyl)...)
Show SMILES CC(c1nnc([nH]1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1Cl)C(F)(F)F
PDB

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15.9n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408547
PNG
((R)- or (S)-6-(5-(1-(2- fluoro-4-(trifluoromethyl)...)
Show SMILES CC(c1nnc(-c2cc(=O)[nH]c(C)n2)n1C)c1ccc(cc1F)C(F)(F)F
PDB

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16n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408538
PNG
(US10358435, Example 54 | US10358435, Example 55)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1nnn2c1CCC[C@@]2(C)c1ccc(cc1)C(F)(F)F
PDB

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16.2n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408551
PNG
((R)- or (S)-6-(5-(1-(2- chloro-4-(trifluoromethyl)...)
Show SMILES CC(c1nnc(-c2cc(=O)[nH]c(C)n2)n1C)c1ccc(cc1Cl)C(F)(F)F
PDB

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17n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408500
PNG
((R)- or (S)-6-(1-(1-(2,3-difluoro- 4-(trifluoromet...)
Show SMILES CCc1ccc(C(C)n2cc(nn2)-c2cc(=O)[nH]c(C)n2)c(F)c1F
PDB

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17.7n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408533
PNG
((R)- or (S)-6-(7-(2-fluoro-4- (trifluoromethyl)phe...)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1nnn2C(CCCc12)c1ccc(cc1F)C(F)(F)F
PDB

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20.7n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408493
PNG
(1-(1-azidoethyl)-2,3- difluoro-4-(trifluoromethyl)...)
Show SMILES CC(N=[N+]=[N-])c1ccc(c(F)c1F)C(F)(F)F
Show InChI InChI=1S/C9H6F5N3/c1-4(16-17-15)5-2-3-6(9(12,13)14)8(11)7(5)10/h2-4H,1H3
PDB

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20.9n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408523
PNG
((R)- or (S)-6-(1-(1-(2-fluoro-4- (trifluoromethyl)...)
Show SMILES CC(C)C(c1ccc(cc1F)C(F)(F)F)n1cc(nn1)-c1cc(=O)[nH]c(C)n1
PDB

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22.6n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408547
PNG
((R)- or (S)-6-(5-(1-(2- fluoro-4-(trifluoromethyl)...)
Show SMILES CC(c1nnc(-c2cc(=O)[nH]c(C)n2)n1C)c1ccc(cc1F)C(F)(F)F
PDB

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23.3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM408493
PNG
(1-(1-azidoethyl)-2,3- difluoro-4-(trifluoromethyl)...)
Show SMILES CC(N=[N+]=[N-])c1ccc(c(F)c1F)C(F)(F)F
Show InChI InChI=1S/C9H6F5N3/c1-4(16-17-15)5-2-3-6(9(12,13)14)8(11)7(5)10/h2-4H,1H3
PDB

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24.9n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408556
PNG
(US10358435, Example 72 | US10358435, Example 73)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1nnc2n1CCCC2(C)c1ccc(cc1)C(F)(F)F
PDB

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26.9n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408554
PNG
(US10358435, Example 70 | US10358435, Example 71)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1nnc2[C@@H](CCCn12)c1ccc(cc1)C(F)(F)F
PDB

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US Patent
27n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408540
PNG
((R)- or (S)-6-(7-ethyl-7-(4- (trifluoromethyl)phen...)
Show SMILES CCC1(COCc2c(nnn12)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
PDB

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29n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408564
PNG
(US10358435, Example 80 | US10358435, Example 81)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1nnc2n1CCC[C@@]2(C)c1ccc(cc1F)C(F)(F)F
PDB

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30.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408533
PNG
((R)- or (S)-6-(7-(2-fluoro-4- (trifluoromethyl)phe...)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1nnn2C(CCCc12)c1ccc(cc1F)C(F)(F)F
PDB

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33n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408496
PNG
(1-(2-fluoro-4- (trifluoromethyl) phenyl)propan-1-o...)
Show SMILES CCC(O)c1ccc(cc1F)C(F)(F)F
Show InChI InChI=1S/C10H10F4O/c1-2-9(15)7-4-3-6(5-8(7)11)10(12,13)14/h3-5,9,15H,2H2,1H3
PDB

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36.2n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408479
PNG
(US10358435, Example 1)
Show SMILES COc1cc(nc(CC2CC2)n1)C#C
Show InChI InChI=1S/C11H12N2O/c1-3-9-7-11(14-2)13-10(12-9)6-8-4-5-8/h1,7-8H,4-6H2,2H3
PDB

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36.3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408495
PNG
(1-(2-chloro-4- (trifluoromethyl) phenyl)ethanol | ...)
Show SMILES CC(O)c1ccc(cc1Cl)C(F)(F)F
Show InChI InChI=1S/C9H8ClF3O/c1-5(14)7-3-2-6(4-8(7)10)9(11,12)13/h2-5,14H,1H3
PDB

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37.8n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408525
PNG
(US10358435, Example 41 | US10358435, Example 42)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1cn(nn1)C(C1CC1)c1ccc(cc1F)C(F)(F)F
PDB

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38n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408504
PNG
(1-(2-azidopropan-2-yl)-2- chloro-4-(trifluoromethy...)
Show SMILES CC(C)(N=[N+]=[N-])c1ccc(cc1Cl)C(F)(F)F
Show InChI InChI=1S/C10H9ClF3N3/c1-9(2,16-17-15)7-4-3-6(5-8(7)11)10(12,13)14/h3-5H,1-2H3
PDB

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38.8n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM408495
PNG
(1-(2-chloro-4- (trifluoromethyl) phenyl)ethanol | ...)
Show SMILES CC(O)c1ccc(cc1Cl)C(F)(F)F
Show InChI InChI=1S/C9H8ClF3O/c1-5(14)7-3-2-6(4-8(7)10)9(11,12)13/h2-5,14H,1H3
PDB

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39.4n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408518
PNG
(US10358435, Example 35 | US10358435, Example 36)
Show SMILES C[C@H](c1ccc(cc1Cl)C(F)(F)F)n1cc(nn1)-c1cc(=O)[nH]c(C)n1
PDB

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41.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408531
PNG
(US10358435, Example 47 | US10358435, Example 48)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1nnn2[C@@H](CCCc12)c1ccc(cc1)C(F)(F)F
PDB

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42.4n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408527
PNG
(US10358435, Example 43 | US10358435, Example 44)
Show SMILES C[C@@H](c1ccc(cc1Cl)C(F)(F)F)n1nnc(c1C)-c1cc(=O)[nH]c(C)n1
PDB

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44n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM408496
PNG
(1-(2-fluoro-4- (trifluoromethyl) phenyl)propan-1-o...)
Show SMILES CCC(O)c1ccc(cc1F)C(F)(F)F
Show InChI InChI=1S/C10H10F4O/c1-2-9(15)7-4-3-6(5-8(7)11)10(12,13)14/h3-5,9,15H,2H2,1H3
PDB

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44.7n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408510
PNG
((R)- or (S)-6-(1-(1-(2-fluoro-4- (trifluoromethyl)...)
Show SMILES CC(c1ccc(cc1F)C(F)(F)F)n1cc(nn1)-c1cc(=O)[nH]c(C)n1
PDB

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46.6n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408499
PNG
((S)- or (R)-6-(1-(1-(2-chloro- 4-ethylphenyl)ethyl...)
Show SMILES CCc1ccc(C(C)n2cc(nn2)-c2cc(=O)[nH]c(C)n2)c(Cl)c1
PDB

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46.7n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408497
PNG
(1-(2-fluoro-4- (trifluoromethyl)phenyl)- 2-methylp...)
Show SMILES CC(C)C(O)c1ccc(cc1F)C(F)(F)F
Show InChI InChI=1S/C11H12F4O/c1-6(2)10(16)8-4-3-7(5-9(8)12)11(13,14)15/h3-6,10,16H,1-2H3
PDB

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47n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408531
PNG
(US10358435, Example 47 | US10358435, Example 48)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1nnn2[C@@H](CCCc12)c1ccc(cc1)C(F)(F)F
PDB

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48n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM408490
PNG
(1-(1-azidoethyl)-4- (trifluoromethoxy)benzene | US...)
Show SMILES CC(N=[N+]=[N-])c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C9H8F3N3O/c1-6(14-15-13)7-2-4-8(5-3-7)16-9(10,11)12/h2-6H,1H3
PDB

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50.4n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408483
PNG
(4-ethynyl-6-((4-methoxybenzyl)oxy)- 2-methylpyrimi...)
Show SMILES COc1ccc(COc2cc(nc(C)n2)C#C)cc1
Show InChI InChI=1S/C15H14N2O2/c1-4-13-9-15(17-11(2)16-13)19-10-12-5-7-14(18-3)8-6-12/h1,5-9H,10H2,2-3H3
PDB

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52.2n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408545
PNG
((R)- or (S)-6-(5-(1-(2- fluoro-4-(trifluoromethyl)...)
Show SMILES CC(c1nnc([nH]1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1F)C(F)(F)F
PDB

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52.7n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408554
PNG
(US10358435, Example 70 | US10358435, Example 71)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1nnc2[C@@H](CCCn12)c1ccc(cc1)C(F)(F)F
PDB

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54.3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM408497
PNG
(1-(2-fluoro-4- (trifluoromethyl)phenyl)- 2-methylp...)
Show SMILES CC(C)C(O)c1ccc(cc1F)C(F)(F)F
Show InChI InChI=1S/C11H12F4O/c1-6(2)10(16)8-4-3-7(5-9(8)12)11(13,14)15/h3-6,10,16H,1-2H3
PDB

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54.8n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408490
PNG
(1-(1-azidoethyl)-4- (trifluoromethoxy)benzene | US...)
Show SMILES CC(N=[N+]=[N-])c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C9H8F3N3O/c1-6(14-15-13)7-2-4-8(5-3-7)16-9(10,11)12/h2-6H,1H3
PDB

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55.8n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408578
PNG
((S)- or (R)-6-(8-(2-Fluoro-4- (triflouromethyl)phe...)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1nnn2c1CCCCC2(C)c1ccc(cc1F)C(F)(F)F
PDB

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56.3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408508
PNG
(1-(2-azidopropan-2-yl)-2- methyl-4-(trifluoromethy...)
Show SMILES Cc1cc(ccc1C(C)(C)N=[N+]=[N-])C(F)(F)F
Show InChI InChI=1S/C11H12F3N3/c1-7-6-8(11(12,13)14)4-5-9(7)10(2,3)16-17-15/h4-6H,1-3H3
PDB

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58.4n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408485
PNG
((R)- or (S)-6-(2-(1-(2-chloro-4- ethylphenyl)ethyl...)
Show SMILES CCc1ccc(C(C)n2ncc(n2)-c2cc(=O)[nH]c(C)n2)c(Cl)c1
PDB

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60.9n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408553
PNG
(US10358435, Example 69)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1nnc(n1C)C(C)(C)c1ccc(cc1F)C(F)(F)F
Show InChI InChI=1S/C18H17F4N5O/c1-9-23-13(8-14(28)24-9)15-25-26-16(27(15)4)17(2,3)11-6-5-10(7-12(11)19)18(20,21)22/h5-8H,1-4H3,(H,23,24,28)
PDB

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66.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408578
PNG
((S)- or (R)-6-(8-(2-Fluoro-4- (triflouromethyl)phe...)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1nnn2c1CCCCC2(C)c1ccc(cc1F)C(F)(F)F
PDB

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67n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408537
PNG
(2-methyl-6-(7-(4- (trifluoromethyl)phenyl)-6,7- di...)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1nnn2C(COCc12)c1ccc(cc1)C(F)(F)F
PDB

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US Patent
73.2n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408492
PNG
(1-(1-azidoethyl)-4- (pentafluorothio)benzene | US1...)
Show SMILES CC(N=[N+]=[N-])c1ccc(cc1)S(F)(F)(F)(F)F
Show InChI InChI=1S/C8H8F5N3S/c1-6(15-16-14)7-2-4-8(5-3-7)17(9,10,11,12)13/h2-6H,1H3
PDB

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76.8n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408535
PNG
((R)- or (S)-2-methyl-6-(8-(4- (trifluoromethyl)phe...)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1nnn2C(CCCCc12)c1ccc(cc1)C(F)(F)F
PDB

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79.9n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM408492
PNG
(1-(1-azidoethyl)-4- (pentafluorothio)benzene | US1...)
Show SMILES CC(N=[N+]=[N-])c1ccc(cc1)S(F)(F)(F)(F)F
Show InChI InChI=1S/C8H8F5N3S/c1-6(15-16-14)7-2-4-8(5-3-7)17(9,10,11,12)13/h2-6H,1H3
PDB

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98.9n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408516
PNG
(6-(1-(2-(4-ethyl-2-methylphenyl) propan-2-yl)-1H-1...)
Show SMILES CCc1ccc(c(C)c1)C(C)(C)n1cc(nn1)-c1cc(=O)[nH]c(C)n1
Show InChI InChI=1S/C19H23N5O/c1-6-14-7-8-15(12(2)9-14)19(4,5)24-11-17(22-23-24)16-10-18(25)21-13(3)20-16/h7-11H,6H2,1-5H3,(H,20,21,25)
PDB

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99.6n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408568
PNG
(US10358435, Example 84 | US10358435, Example 85)
Show SMILES C[C@H](c1ncn(n1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1F)C(F)(F)F
PDB

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102n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408481
PNG
(2-benzyl-4-ethynyl-6- methoxypyrimidine | US103584...)
Show SMILES COc1cc(nc(Cc2ccccc2)n1)C#C
Show InChI InChI=1S/C14H12N2O/c1-3-12-10-14(17-2)16-13(15-12)9-11-7-5-4-6-8-11/h1,4-8,10H,9H2,2H3
PDB

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112n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408489
PNG
(1-(1-azidoethyl)-2-fluoro- 4-(trifluoromethoxy) be...)
Show SMILES CC(N=[N+]=[N-])c1ccc(OC(F)(F)F)cc1F
Show InChI InChI=1S/C9H7F4N3O/c1-5(15-16-14)7-3-2-6(4-8(7)10)17-9(11,12)13/h2-5H,1H3
PDB

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132n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408535
PNG
((R)- or (S)-2-methyl-6-(8-(4- (trifluoromethyl)phe...)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1nnn2C(CCCCc12)c1ccc(cc1)C(F)(F)F
PDB

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139n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408570
PNG
(US10358435, Example 86)
Show SMILES CC(c1ccc(cc1F)C(F)(F)F)n1cnc(n1)-c1cc(=O)[nH]c(C)n1
PDB

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167n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408542
PNG
((R)- or (S)-6-(7-(2-fluoro-4- (trifluoromethyl)phe...)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1nnn2c1COCC2(C)c1ccc(cc1F)C(F)(F)F
PDB

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178n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408560
PNG
(US10358435, Example 76 | US10358435, Example 77)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1nnn2c1CCC[C@@]2(C)c1ccc(OC(F)(F)F)cc1
PDB

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182n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408502
PNG
((R)- or (S)-6-(1-(1-(2,5-difluoro- 4-(triufluorome...)
Show SMILES CC(c1cc(F)c(cc1F)C(F)(F)F)n1cc(nn1)-c1cc(=O)[nH]c(C)n1
PDB

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203n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Phosphodiesterase


(Macaca mulatta (Rhesus macaque))
BDBM408544
PNG
(US10358435, Example 60)
Show SMILES CC(c1nnc([nH]1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
PDB

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204n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408582
PNG
((R)- or (S)-6-(6-(2-Fluoro-4- (trifluoromethyl)phe...)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1nnn2c1CCC2(C)c1ccc(cc1F)C(F)(F)F
PDB

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218n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408566
PNG
(US10358435, Example 82 | US10358435, Example 83)
Show SMILES C[C@H](c1cnn(n1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1Cl)C(F)(F)F
PDB

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221n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408568
PNG
(US10358435, Example 84 | US10358435, Example 85)
Show SMILES C[C@H](c1ncn(n1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1F)C(F)(F)F
PDB

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224n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408538
PNG
(US10358435, Example 54 | US10358435, Example 55)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1nnn2c1CCC[C@@]2(C)c1ccc(cc1)C(F)(F)F
PDB

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232n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408545
PNG
((R)- or (S)-6-(5-(1-(2- fluoro-4-(trifluoromethyl)...)
Show SMILES CC(c1nnc([nH]1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1F)C(F)(F)F
PDB

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387n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408560
PNG
(US10358435, Example 76 | US10358435, Example 77)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1nnn2c1CCC[C@@]2(C)c1ccc(OC(F)(F)F)cc1
PDB

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402n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408580
PNG
(US10358435, Example 95 | US10358435, Example 96)
Show SMILES CCc1ccc(c(F)c1)[C@@]1(C)CCCc2c(nnn12)-c1cc(=O)[nH]c(C)n1
PDB

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430n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408573
PNG
(US10358435, Example 89 | US10358435, Example 90)
Show SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)-c2nnn3c2CCC[C@@]3(C)c2ccc(cc2F)C(F)(F)F)cc1
PDB

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449n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408571
PNG
(US10358435, Example 87 | US10358435, Example 88)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1nnn2c1CCC[C@@]2(C)c1ccc(cc1Cl)C(F)(F)F
PDB

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478n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408549
PNG
((R)- or (S)-6-(5-(1-(2- chloro-4-(trifluoromethyl)...)
Show SMILES CC(c1nnc([nH]1)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1Cl)C(F)(F)F
PDB

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525n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408540
PNG
((R)- or (S)-6-(7-ethyl-7-(4- (trifluoromethyl)phen...)
Show SMILES CCC1(COCc2c(nnn12)-c1cc(=O)[nH]c(C)n1)c1ccc(cc1)C(F)(F)F
PDB

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616n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408575
PNG
((S)- or (R)-6-(7-(2-Fluoro-4- (trifluoromethyl)phe...)
Show SMILES COc1cccc(Cc2nc(cc(=O)[nH]2)-c2nnn3c2CCCC3(C)c2ccc(cc2F)C(F)(F)F)c1
PDB

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728n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408562
PNG
(US10358435, Example 78 | US10358435, Example 79)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1nnn2c1CCC[C@@]2(C)c1ccc(cc1C)C(F)(F)F
PDB

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804n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408556
PNG
(US10358435, Example 72 | US10358435, Example 73)
Show SMILES Cc1nc(cc(=O)[nH]1)-c1nnc2n1CCCC2(C)c1ccc(cc1)C(F)(F)F
PDB

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864n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408482
PNG
(4-ethynyl-6-methoxy-2- methylpyrimidine | US103584...)
Show SMILES COc1cc(nc(C)n1)C#C
Show InChI InChI=1S/C8H8N2O/c1-4-7-5-8(11-3)10-6(2)9-7/h1,5H,2-3H3
PDB

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1.03E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408529
PNG
((R)- or (S)-6-(5-butyl-1- (1-(2-chloro-4-(trifluor...)
Show SMILES CCCCc1c(nnn1C(C)c1ccc(cc1Cl)C(F)(F)F)-c1cc(=O)[nH]c(C)n1
PDB

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1.10E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408480
PNG
(US10358435, Example 2)
Show SMILES CC\C=C\c1nc(OC)cc(n1)C#C
Show InChI InChI=1S/C11H12N2O/c1-4-6-7-10-12-9(5-2)8-11(13-10)14-3/h2,6-8H,4H2,1,3H3/b7-6+
PDB

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1.30E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408485
PNG
((R)- or (S)-6-(2-(1-(2-chloro-4- ethylphenyl)ethyl...)
Show SMILES CCc1ccc(C(C)n2ncc(n2)-c2cc(=O)[nH]c(C)n2)c(Cl)c1
PDB

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1.55E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))
BDBM408484
PNG
((S)- or (R)-2-methyl-6-(2-(1- (2-methyl-4-(trifluo...)
Show SMILES CC(c1ccc(cc1C)C(F)(F)F)n1ncc(n1)-c1cc(=O)[nH]c(C)n1
PDB

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1.90E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...


US Patent US10358435 (2019)


BindingDB Entry DOI: 10.7270/Q2Q242M7
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%