BindingDB logo
myBDB logout

Patent code US10358436

Compile Data Set for Download or QSAR

Found 643 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aurora kinase B


(Homo sapiens (Human))
BDBM50073582
PNG
(CHEMBL3408942 | US10358436, Example A109 | US99078...)
Show SMILES CN(C)Cc1ccc(\C=C\c2n[nH]c3cc(ccc23)[C@@H]2C[C@@]22C(=O)N(C)c3ccccc23)cc1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375409
PNG
(US10358436, Example A121 | US9907800, Example A121)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(n[nH]c4c3)-c3ccc(cc3)N3CCC(CC3)N3CCOCC3)c2c1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375415
PNG
(US10358436, Example A127 | US9907800, Example A127)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(n[nH]c4c3)-c3ccc(cc3)N3CC[C@H](C3)N(C)C)c2c1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375419
PNG
(US10358436, Example A131 | US9907800, Example A131)
Show SMILES COCCN1C(=O)[C@@]2(C[C@H]2c2ccc3c(\C=C\c4ccc(CN(C)C)cc4)n[nH]c3c2)c2ccccc12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375422
PNG
(US10358436, Example A135 | US9907800, Example A134...)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5cccc(CN(C)C)c5)n[nH]c4c3)c2c1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375436
PNG
(US10358436, Example A148 | US9907800, Example A148)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(n[nH]c4c3)-c3ccc(cc3)C(=O)N3CCN(C)CC3)c2c1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375331
PNG
(US10358436, Example A51 | US9907800, Example A177 ...)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CCN6CCOCC6)cc5)n[nH]c4c3)c2c1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM50044675
PNG
(CHEMBL3353354 | US10358436, Example A56 | US990780...)
Show SMILES O=C1Nc2ccccc2[C@]11C[C@H]1c1ccc2c(\C=C\c3ccc(CN4CCOCC4)cc3)n[nH]c2c1
PDB

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM50044675
PNG
(CHEMBL3353354 | US10358436, Example A56 | US990780...)
Show SMILES O=C1Nc2ccccc2[C@]11C[C@H]1c1ccc2c(\C=C\c3ccc(CN4CCOCC4)cc3)n[nH]c2c1
PDB

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375347
PNG
(US10358436, Example A67 | US9907800, Example A67)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(n[nH]c4c3)-c3ccc(OCCN4CCCCC4)cc3)c2c1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375348
PNG
(US10358436, Example A68 | US9907800, Example A68)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(n[nH]c4c3)-c3ccc(OCCN4CCOCC4)cc3)c2c1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50073549
PNG
(CHEMBL3408953 | US10358436, Example A72 | US990780...)
Show SMILES O=C1Nc2ccccc2[C@]11C[C@H]1c1ccc2c(\C=C\c3ccc(CN4CCCOCC4)cc3)n[nH]c2c1
Show InChI InChI=1S/C31H30N4O2/c36-30-31(25-4-1-2-5-28(25)32-30)19-26(31)23-11-12-24-27(33-34-29(24)18-23)13-10-21-6-8-22(9-7-21)20-35-14-3-16-37-17-15-35/h1-2,4-13,18,26H,3,14-17,19-20H2,(H,32,36)(H,33,34)/b13-10+/t26-,31-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
CHEBI
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375371
PNG
(US10358436, Example A90 | US9907800, Example A89 |...)
Show SMILES CN1C(=O)[C@@]2(C[C@H]2c2ccc3c(\C=C\c4ccc(cc4)N4CCNCC4)n[nH]c3c2)c2ccccc12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM408675
PNG
(US10358436, Example A91)
Show SMILES O=C1Nc2ccccc2[C@]11CC1c1ccc2c(\C=C\c3ccc(cc3)N3CCNCC3)n[nH]c2c1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375384
PNG
(US10358436, Example A101 | US9907800, Example A101)
Show SMILES COc1ccc2N(C)C(=O)[C@@]3(C[C@H]3c3ccc4c(n[nH]c4c3)-c3ccc(cc3)N3CCNCC3)c2c1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50073554
PNG
(CHEMBL3408940 | US10358436, Example A110 | US99078...)
Show SMILES CN1C(=O)[C@@]2(C[C@H]2c2ccc3c(\C=C\c4ccc(nc4)N4CCN(C)CC4)n[nH]c3c2)c2ccccc12
Show InChI InChI=1S/C30H30N6O/c1-34-13-15-36(16-14-34)28-12-8-20(19-31-28)7-11-25-22-10-9-21(17-26(22)33-32-25)24-18-30(24)23-5-3-4-6-27(23)35(2)29(30)37/h3-12,17,19,24H,13-16,18H2,1-2H3,(H,32,33)/b11-7+/t24-,30-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
CHEBI
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375400
PNG
(US10358436, Example A116 | US9907800, Example A116)
Show SMILES Fc1cc(\C=C\c2n[nH]c3cc(ccc23)[C@@H]2C[C@@]22C(=O)Nc3ccccc23)cc(F)c1CN1CCOCC1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375400
PNG
(US10358436, Example A116 | US9907800, Example A116)
Show SMILES Fc1cc(\C=C\c2n[nH]c3cc(ccc23)[C@@H]2C[C@@]22C(=O)Nc3ccccc23)cc(F)c1CN1CCOCC1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM408701
PNG
(US10358436, Example A117)
Show SMILES COc1ccc2NC(=O)[C@@]3(CC3c3ccc4c(n[nH]c4c3)-c3ccc(nc3)N3CCC(O)CC3)c2c1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM408703
PNG
(US10358436, Example A119)
Show SMILES COc1ccc2NC(=O)[C@@]3(CC3c3ccc4c(n[nH]c4c3)-c3ccc(cc3)N3CCC(CC3)N(C)C)c2c1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM408706
PNG
(US10358436, Example A122)
Show SMILES COc1ccc2NC(=O)[C@@]3(CC3c3ccc4c(n[nH]c4c3)-c3ccc(cc3)C3CCNCC3)c2c1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375416
PNG
(US10358436, Example A128 | US9907800, Example A128)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(n[nH]c4c3)-c3ccc(cc3)N3CC[C@@H](C3)N(C)C)c2c1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375420
PNG
(US10358436, Example A133 | US9907800, Example A132...)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5cccc(CN6CCOCC6)c5)n[nH]c4c3)c2c1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375420
PNG
(US10358436, Example A133 | US9907800, Example A132...)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5cccc(CN6CCOCC6)c5)n[nH]c4c3)c2c1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375422
PNG
(US10358436, Example A135 | US9907800, Example A134...)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5cccc(CN(C)C)c5)n[nH]c4c3)c2c1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM408721
PNG
(US10358436, Example A137)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(n[nH]c4c3)C#Cc3ccc(C=O)cc3)c2c1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM408728
PNG
(US10358436, Example A142)
Show SMILES CCc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(n[nH]c4c3)-c3ccc(cc3)N3CCN(C)CC3)c2c1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50073545
PNG
(CHEMBL3408949 | US10358436, Example A151 | US99078...)
Show SMILES O=C1Nc2ccccc2[C@]11C[C@H]1c1ccc2c(\C=C\c3cccc(CN4CCOCC4)c3)n[nH]c2c1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM408743
PNG
(US10358436, Example A157)
Show SMILES CN1CCN(CC1)c1ccc(\C=C\c2n[nH]c3cc(ccc23)[C@@H]2C[C@@]22C(=O)Nc3ccccc23)cn1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375451
PNG
(US10358436, Example A161 | US9907800, Example A161)
Show SMILES Cc1cc(\C=C\c2n[nH]c3cc(ccc23)C2C[C@@]22C(=O)Nc3ccccc23)ccn1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375453
PNG
(US10358436, Example A163 | US9907800, Example A163)
Show SMILES COc1ccc2NC(=O)[C@@]3(CC3c3ccc4c(\C=C\c5ccc(nc5)N5CCNCC5)n[nH]c4c3)c2c1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM408752
PNG
(US10358436, Example A166)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(n[nH]c4c3)-c3ccc(CN(C)C)cc3)c2c1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50044673
PNG
(CHEMBL3353353 | US10358436, Example A167)
Show SMILES CCc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN(C)C)cc5)n[nH]c4c3)c2c1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM408754
PNG
(US10358436, Example A168)
Show SMILES COc1cc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN(C)C)cc5)n[nH]c4c3)c2cc1OC
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375459
PNG
(US10358436, Example A169 | US9907800, Example A169)
Show SMILES CN(C)Cc1ccc(\C=C\c2n[nH]c3cc(ccc23)C2C[C@@]22C(=O)Nc3ccc(C)cc23)cc1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375461
PNG
(US10358436, Example A171 | US9907800, Example A171)
Show SMILES CN(C)Cc1ccc(\C=C\c2n[nH]c3cc(ccc23)C2C[C@@]22C(=O)Nc3ccc(Cl)cc23)cc1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375465
PNG
(US10358436, Example A174 | US9907800, Example A174)
Show SMILES COc1ccc2NC(=O)[C@@]3(CC3c3ccc4c(\C=C\c5ccc(cc5)N5CCN(C)CC5)n[nH]c4c3)c2c1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Aurora kinase A/Targeting protein for Xklp2


(Homo sapiens (Human))
BDBM375419
PNG
(US10358436, Example A131 | US9907800, Example A131)
Show SMILES COCCN1C(=O)[C@@]2(C[C@H]2c2ccc3c(\C=C\c4ccc(CN(C)C)cc4)n[nH]c3c2)c2ccccc12
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Aurora A inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375480
PNG
(US10358436, Example A189 | US9907800, Example A189)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(cc5)N5CCN(CC5)C(C)C)n[nH]c4c3)c2c1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM375507
PNG
(US10358436, Example A216 | US9907800, Example A216)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5cc(F)c(CN(C)C)c(F)c5)n[nH]c4c3)c2c1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375507
PNG
(US10358436, Example A216 | US9907800, Example A216)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5cc(F)c(CN(C)C)c(F)c5)n[nH]c4c3)c2c1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50044672
PNG
(CHEMBL3353358 | US10358436, Example A217 | US99078...)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5cc(F)c(CN6CCOCC6)c(F)c5)n[nH]c4c3)c2c1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50044669
PNG
(CHEMBL3353356 | US10358436, Example A220 | US99078...)
Show SMILES Fc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN6CCOCC6)cc5)n[nH]c4c3)c2c1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM375291
PNG
(US10358436, Example A16 | US9907800, Example A16)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(n[nH]c4c3)-c3ccc(nc3)N3CCN(C)CC3)c2c1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
PLK3 inhibition was determined using the Z-Lyte assay kit from Invitrogen (cat #PV3802). The assay was performed using the recommended manufacturer&#...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM408599
PNG
(US10358436, Example A17)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@@H]3c3ccc4c(n[nH]c4c3)-c3ccc(nc3)N3CCN(C)CC3)c2c1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM408600
PNG
(US10358436, Example A18)
Show SMILES CN1CCN(CC1)c1ccc(cn1)-c1n[nH]c2cc(ccc12)[C@@H]1C[C@@]11C(=O)Nc2ccccc12
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM408601
PNG
(US10358436, Example A19)
Show SMILES CN1CCN(CC1)c1ccc(cn1)-c1n[nH]c2cc(ccc12)[C@@H]1C[C@@]11C(=O)Nc2ccc(Br)cc12
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM50044657
PNG
(CHEMBL3353347 | US10358436, Example A24 | US990780...)
Show SMILES CN(C)Cc1ccc(\C=C\c2n[nH]c3cc(ccc23)[C@@H]2C[C@@]22C(=O)Nc3ccccc23)cc1
PDB

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM50044657
PNG
(CHEMBL3353347 | US10358436, Example A24 | US990780...)
Show SMILES CN(C)Cc1ccc(\C=C\c2n[nH]c3cc(ccc23)[C@@H]2C[C@@]22C(=O)Nc3ccccc23)cc1
PDB

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50044657
PNG
(CHEMBL3353347 | US10358436, Example A24 | US990780...)
Show SMILES CN(C)Cc1ccc(\C=C\c2n[nH]c3cc(ccc23)[C@@H]2C[C@@]22C(=O)Nc3ccccc23)cc1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



University Health Network

US Patent


Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)


BindingDB Entry DOI: 10.7270/Q2K939WH
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 643 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%