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Patent code US10358446

Compile Data Set for Download or QSAR
Found 67 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM408604
PNG
(US10358446, Compound 132)
Show SMILES COc1ccc(Oc2ccc(cc2)-n2c3cnccc3n(-c3cccc(NC(=O)C=C)c3)c2=O)cc1OC
Show InChI InChI=1S/C29H24N4O5/c1-4-28(34)31-19-6-5-7-21(16-19)33-24-14-15-30-18-25(24)32(29(33)35)20-8-10-22(11-9-20)38-23-12-13-26(36-2)27(17-23)37-3/h4-18H,1H2,2-3H3,(H,31,34)
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n/an/a<10n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM408589
PNG
(US10358446, Compound 5)
Show SMILES Clc1cc(ccc1Oc1ccccc1)-n1c2cnccc2n([C@@H]2CCN(C2)C(=O)C=C)c1=O
Show InChI InChI=1S/C25H21ClN4O3/c1-2-24(31)28-13-11-18(16-28)30-21-10-12-27-15-22(21)29(25(30)32)17-8-9-23(20(26)14-17)33-19-6-4-3-5-7-19/h2-10,12,14-15,18H,1,11,13,16H2/t18-/m1/s1
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n/an/a<10n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM408593
PNG
(US10358446, Compound 31)
Show SMILES C=CC(=O)N1CCC(CC1)n1c2ccncc2n(-c2ccc(Oc3ccccc3)cc2)c1=O
Show InChI InChI=1S/C26H24N4O3/c1-2-25(31)28-16-13-20(14-17-28)29-23-12-15-27-18-24(23)30(26(29)32)19-8-10-22(11-9-19)33-21-6-4-3-5-7-21/h2-12,15,18,20H,1,13-14,16-17H2
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n/an/a<10n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM408592
PNG
(US10358446, Compound 26)
Show SMILES CC(C)Oc1cccc(Oc2ccc(cc2)-n2c3cnccc3n([C@@H]3CCN(C3)C(=O)C=C)c2=O)c1
Show InChI InChI=1S/C28H28N4O4/c1-4-27(33)30-15-13-21(18-30)32-25-12-14-29-17-26(25)31(28(32)34)20-8-10-22(11-9-20)36-24-7-5-6-23(16-24)35-19(2)3/h4-12,14,16-17,19,21H,1,13,15,18H2,2-3H3/t21-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM408594
PNG
(US10358446, Compound 38)
Show SMILES Clc1ccc(Oc2ccc(cc2)-n2c3cnccc3n([C@@H]3CCN(C3)C(=O)C=C)c2=O)cc1Cl
Show InChI InChI=1S/C25H20Cl2N4O3/c1-2-24(32)29-12-10-17(15-29)31-22-9-11-28-14-23(22)30(25(31)33)16-3-5-18(6-4-16)34-19-7-8-20(26)21(27)13-19/h2-9,11,13-14,17H,1,10,12,15H2/t17-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM408605
PNG
(US10358446, Compound 133)
Show SMILES Fc1cc(ccc1Oc1ccccc1)-n1c2cnccc2n(-c2cccc(NC(=O)C=C)c2)c1=O
Show InChI InChI=1S/C27H19FN4O3/c1-2-26(33)30-18-7-6-8-19(15-18)31-23-13-14-29-17-24(23)32(27(31)34)20-11-12-25(22(28)16-20)35-21-9-4-3-5-10-21/h2-17H,1H2,(H,30,33)
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM408595
PNG
(US10358446, Compound 51)
Show SMILES Fc1cc(ccc1Oc1cccc(Cl)c1)-n1c2cnccc2n(-c2cccc(NC(=O)C=C)c2)c1=O
Show InChI InChI=1S/C27H18ClFN4O3/c1-2-26(34)31-18-6-4-7-19(14-18)32-23-11-12-30-16-24(23)33(27(32)35)20-9-10-25(22(29)15-20)36-21-8-3-5-17(28)13-21/h2-16H,1H2,(H,31,34)
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM408596
PNG
(US10358446, Compound 60)
Show SMILES Fc1c(Cl)cccc1Oc1ccc(cc1)-n1c2cnccc2n([C@@H]2CCCN(C2)C(=O)C=C)c1=O
Show InChI InChI=1S/C26H22ClFN4O3/c1-2-24(33)30-14-4-5-18(16-30)32-21-12-13-29-15-22(21)31(26(32)34)17-8-10-19(11-9-17)35-23-7-3-6-20(27)25(23)28/h2-3,6-13,15,18H,1,4-5,14,16H2/t18-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM408586
PNG
(US10358446, Compound 2)
Show SMILES COc1cccc(Oc2ccc(cc2)-n2c3cnccc3n([C@@H]3CCN(C3)C(=O)C=C)c2=O)c1
Show InChI InChI=1S/C26H24N4O4/c1-3-25(31)28-14-12-19(17-28)30-23-11-13-27-16-24(23)29(26(30)32)18-7-9-20(10-8-18)34-22-6-4-5-21(15-22)33-2/h3-11,13,15-16,19H,1,12,14,17H2,2H3/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM408588
PNG
(US10358446, Compound 4)
Show SMILES Cc1cccc(Oc2ccc(cc2)-n2c3cnccc3n([C@@H]3CCN(C3)C(=O)C=C)c2=O)c1
Show InChI InChI=1S/C26H24N4O3/c1-3-25(31)28-14-12-20(17-28)30-23-11-13-27-16-24(23)29(26(30)32)19-7-9-21(10-8-19)33-22-6-4-5-18(2)15-22/h3-11,13,15-16,20H,1,12,14,17H2,2H3/t20-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM408590
PNG
(US10358446, Compound 8)
Show SMILES COc1cccc(Oc2ccc(cc2)-n2c3cnccc3n([C@H]3CCCN(C3)C(=O)C=C)c2=O)c1Cl
Show InChI InChI=1S/C27H25ClN4O4/c1-3-25(33)30-15-5-6-19(17-30)32-21-13-14-29-16-22(21)31(27(32)34)18-9-11-20(12-10-18)36-24-8-4-7-23(35-2)26(24)28/h3-4,7-14,16,19H,1,5-6,15,17H2,2H3/t19-/m0/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM408585
PNG
(US10358446, Compound 1 | US10358446, Compound 3)
Show SMILES C=CC(=O)N1CC[C@H](C1)n1c2ccncc2n(-c2ccc(Oc3ccccc3)cc2)c1=O
Show InChI InChI=1S/C25H22N4O3/c1-2-24(30)27-15-13-19(17-27)29-22-12-14-26-16-23(22)28(25(29)31)18-8-10-21(11-9-18)32-20-6-4-3-5-7-20/h2-12,14,16,19H,1,13,15,17H2/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM408598
PNG
(US10358446, Compound 128)
Show SMILES Fc1cc(F)cc(Oc2ccc(cc2)-n2c3cnccc3n(-c3cccc(NC(=O)C=C)c3)c2=O)c1
Show InChI InChI=1S/C27H18F2N4O3/c1-2-26(34)31-19-4-3-5-21(15-19)33-24-10-11-30-16-25(24)32(27(33)35)20-6-8-22(9-7-20)36-23-13-17(28)12-18(29)14-23/h2-16H,1H2,(H,31,34)
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM408597
PNG
(US10358446, Compound 103)
Show SMILES Fc1cccc(Oc2ccc(cc2)-n2c3cnccc3n([C@@H]3CCN(C3)C(=O)C=C)c2=O)c1Cl
Show InChI InChI=1S/C25H20ClFN4O3/c1-2-23(32)29-13-11-17(15-29)31-20-10-12-28-14-21(20)30(25(31)33)16-6-8-18(9-7-16)34-22-5-3-4-19(27)24(22)26/h2-10,12,14,17H,1,11,13,15H2/t17-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM408591
PNG
(US10358446, Compound 20)
Show SMILES Cc1cccc(Oc2ccc(cc2Cl)-n2c3cnccc3n([C@@H]3CCN(C3)C(=O)C=C)c2=O)c1
Show InChI InChI=1S/C26H23ClN4O3/c1-3-25(32)29-12-10-19(16-29)31-22-9-11-28-15-23(22)30(26(31)33)18-7-8-24(21(27)14-18)34-20-6-4-5-17(2)13-20/h3-9,11,13-15,19H,1,10,12,16H2,2H3/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Blk


(Homo sapiens (Human))
BDBM408586
PNG
(US10358446, Compound 2)
Show SMILES COc1cccc(Oc2ccc(cc2)-n2c3cnccc3n([C@@H]3CCN(C3)C(=O)C=C)c2=O)c1
Show InChI InChI=1S/C26H24N4O4/c1-3-25(31)28-14-12-19(17-28)30-23-11-13-27-16-24(23)29(26(30)32)18-7-9-20(10-8-18)34-22-6-4-5-21(15-22)33-2/h3-11,13,15-16,19H,1,12,14,17H2,2H3/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Blk


(Homo sapiens (Human))
BDBM408605
PNG
(US10358446, Compound 133)
Show SMILES Fc1cc(ccc1Oc1ccccc1)-n1c2cnccc2n(-c2cccc(NC(=O)C=C)c2)c1=O
Show InChI InChI=1S/C27H19FN4O3/c1-2-26(33)30-18-7-6-8-19(15-18)31-23-13-14-29-17-24(23)32(27(31)34)20-11-12-25(22(28)16-20)35-21-9-4-3-5-10-21/h2-17H,1H2,(H,30,33)
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Blk


(Homo sapiens (Human))
BDBM408596
PNG
(US10358446, Compound 60)
Show SMILES Fc1c(Cl)cccc1Oc1ccc(cc1)-n1c2cnccc2n([C@@H]2CCCN(C2)C(=O)C=C)c1=O
Show InChI InChI=1S/C26H22ClFN4O3/c1-2-24(33)30-14-4-5-18(16-30)32-21-12-13-29-15-22(21)31(26(32)34)17-8-10-19(11-9-17)35-23-7-3-6-20(27)25(23)28/h2-3,6-13,15,18H,1,4-5,14,16H2/t18-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM408585
PNG
(US10358446, Compound 1 | US10358446, Compound 3)
Show SMILES C=CC(=O)N1CC[C@H](C1)n1c2ccncc2n(-c2ccc(Oc3ccccc3)cc2)c1=O
Show InChI InChI=1S/C25H22N4O3/c1-2-24(30)27-15-13-19(17-27)29-22-12-14-26-16-23(22)28(25(29)31)18-8-10-21(11-9-18)32-20-6-4-3-5-7-20/h2-12,14,16,19H,1,13,15,17H2/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Blk


(Homo sapiens (Human))
BDBM408594
PNG
(US10358446, Compound 38)
Show SMILES Clc1ccc(Oc2ccc(cc2)-n2c3cnccc3n([C@@H]3CCN(C3)C(=O)C=C)c2=O)cc1Cl
Show InChI InChI=1S/C25H20Cl2N4O3/c1-2-24(32)29-12-10-17(15-29)31-22-9-11-28-14-23(22)30(25(31)33)16-3-5-18(6-4-16)34-19-7-8-20(26)21(27)13-19/h2-9,11,13-14,17H,1,10,12,15H2/t17-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Blk


(Homo sapiens (Human))
BDBM408585
PNG
(US10358446, Compound 1 | US10358446, Compound 3)
Show SMILES C=CC(=O)N1CC[C@H](C1)n1c2ccncc2n(-c2ccc(Oc3ccccc3)cc2)c1=O
Show InChI InChI=1S/C25H22N4O3/c1-2-24(30)27-15-13-19(17-27)29-22-12-14-26-16-23(22)28(25(29)31)18-8-10-21(11-9-18)32-20-6-4-3-5-7-20/h2-12,14,16,19H,1,13,15,17H2/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Blk


(Homo sapiens (Human))
BDBM408588
PNG
(US10358446, Compound 4)
Show SMILES Cc1cccc(Oc2ccc(cc2)-n2c3cnccc3n([C@@H]3CCN(C3)C(=O)C=C)c2=O)c1
Show InChI InChI=1S/C26H24N4O3/c1-3-25(31)28-14-12-20(17-28)30-23-11-13-27-16-24(23)29(26(30)32)19-7-9-21(10-8-19)33-22-6-4-5-18(2)15-22/h3-11,13,15-16,20H,1,12,14,17H2,2H3/t20-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Blk


(Homo sapiens (Human))
BDBM408589
PNG
(US10358446, Compound 5)
Show SMILES Clc1cc(ccc1Oc1ccccc1)-n1c2cnccc2n([C@@H]2CCN(C2)C(=O)C=C)c1=O
Show InChI InChI=1S/C25H21ClN4O3/c1-2-24(31)28-13-11-18(16-28)30-21-10-12-27-15-22(21)29(25(30)32)17-8-9-23(20(26)14-17)33-19-6-4-3-5-7-19/h2-10,12,14-15,18H,1,11,13,16H2/t18-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM408606
PNG
(US10358446, Compound 138)
Show SMILES COc1c(F)cccc1Oc1ccc(cc1)-n1c2cnccc2n([C@@H]2CCN(C2)C(=O)C=C)c1=O
Show InChI InChI=1S/C26H23FN4O4/c1-3-24(32)29-14-12-18(16-29)31-21-11-13-28-15-22(21)30(26(31)33)17-7-9-19(10-8-17)35-23-6-4-5-20(27)25(23)34-2/h3-11,13,15,18H,1,12,14,16H2,2H3/t18-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Blk


(Homo sapiens (Human))
BDBM408591
PNG
(US10358446, Compound 20)
Show SMILES Cc1cccc(Oc2ccc(cc2Cl)-n2c3cnccc3n([C@@H]3CCN(C3)C(=O)C=C)c2=O)c1
Show InChI InChI=1S/C26H23ClN4O3/c1-3-25(32)29-12-10-19(16-29)31-22-9-11-28-15-23(22)30(26(31)33)18-7-8-24(21(27)14-18)34-20-6-4-5-17(2)13-20/h3-9,11,13-15,19H,1,10,12,16H2,2H3/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Blk


(Homo sapiens (Human))
BDBM408595
PNG
(US10358446, Compound 51)
Show SMILES Fc1cc(ccc1Oc1cccc(Cl)c1)-n1c2cnccc2n(-c2cccc(NC(=O)C=C)c2)c1=O
Show InChI InChI=1S/C27H18ClFN4O3/c1-2-26(34)31-18-6-4-7-19(14-18)32-23-11-12-30-16-24(23)33(27(32)35)20-9-10-25(22(29)15-20)36-21-8-3-5-17(28)13-21/h2-16H,1H2,(H,31,34)
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Blk


(Homo sapiens (Human))
BDBM408606
PNG
(US10358446, Compound 138)
Show SMILES COc1c(F)cccc1Oc1ccc(cc1)-n1c2cnccc2n([C@@H]2CCN(C2)C(=O)C=C)c1=O
Show InChI InChI=1S/C26H23FN4O4/c1-3-24(32)29-14-12-18(16-29)31-21-11-13-28-15-22(21)30(26(31)33)17-7-9-19(10-8-17)35-23-6-4-5-20(27)25(23)34-2/h3-11,13,15,18H,1,12,14,16H2,2H3/t18-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Blk


(Homo sapiens (Human))
BDBM408604
PNG
(US10358446, Compound 132)
Show SMILES COc1ccc(Oc2ccc(cc2)-n2c3cnccc3n(-c3cccc(NC(=O)C=C)c3)c2=O)cc1OC
Show InChI InChI=1S/C29H24N4O5/c1-4-28(34)31-19-6-5-7-21(16-19)33-24-14-15-30-18-25(24)32(29(33)35)20-8-10-22(11-9-20)38-23-12-13-26(36-2)27(17-23)37-3/h4-18H,1H2,2-3H3,(H,31,34)
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Blk


(Homo sapiens (Human))
BDBM408593
PNG
(US10358446, Compound 31)
Show SMILES C=CC(=O)N1CCC(CC1)n1c2ccncc2n(-c2ccc(Oc3ccccc3)cc2)c1=O
Show InChI InChI=1S/C26H24N4O3/c1-2-25(31)28-16-13-20(14-17-28)29-23-12-15-27-18-24(23)30(26(29)32)19-8-10-22(11-9-19)33-21-6-4-3-5-7-21/h2-12,15,18,20H,1,13-14,16-17H2
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Blk


(Homo sapiens (Human))
BDBM408590
PNG
(US10358446, Compound 8)
Show SMILES COc1cccc(Oc2ccc(cc2)-n2c3cnccc3n([C@H]3CCCN(C3)C(=O)C=C)c2=O)c1Cl
Show InChI InChI=1S/C27H25ClN4O4/c1-3-25(33)30-15-5-6-19(17-30)32-21-13-14-29-16-22(21)31(27(32)34)18-9-11-20(12-10-18)36-24-8-4-7-23(35-2)26(24)28/h3-4,7-14,16,19H,1,5-6,15,17H2,2H3/t19-/m0/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Blk


(Homo sapiens (Human))
BDBM408597
PNG
(US10358446, Compound 103)
Show SMILES Fc1cccc(Oc2ccc(cc2)-n2c3cnccc3n([C@@H]3CCN(C3)C(=O)C=C)c2=O)c1Cl
Show InChI InChI=1S/C25H20ClFN4O3/c1-2-23(32)29-13-11-17(15-29)31-20-10-12-28-14-21(20)30(25(31)33)16-6-8-18(9-7-16)34-22-5-3-4-19(27)24(22)26/h2-10,12,14,17H,1,11,13,15H2/t17-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Blk


(Homo sapiens (Human))
BDBM408598
PNG
(US10358446, Compound 128)
Show SMILES Fc1cc(F)cc(Oc2ccc(cc2)-n2c3cnccc3n(-c3cccc(NC(=O)C=C)c3)c2=O)c1
Show InChI InChI=1S/C27H18F2N4O3/c1-2-26(34)31-19-4-3-5-21(15-19)33-24-10-11-30-16-25(24)32(27(33)35)20-6-8-22(9-7-20)36-23-13-17(28)12-18(29)14-23/h2-16H,1H2,(H,31,34)
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Blk


(Homo sapiens (Human))
BDBM408592
PNG
(US10358446, Compound 26)
Show SMILES CC(C)Oc1cccc(Oc2ccc(cc2)-n2c3cnccc3n([C@@H]3CCN(C3)C(=O)C=C)c2=O)c1
Show InChI InChI=1S/C28H28N4O4/c1-4-27(33)30-15-13-21(18-30)32-25-12-14-29-17-26(25)31(28(32)34)20-8-10-22(11-9-20)36-24-7-5-6-23(16-24)35-19(2)3/h4-12,14,16-17,19,21H,1,13,15,18H2,2-3H3/t21-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Blk


(Homo sapiens (Human))
BDBM408585
PNG
(US10358446, Compound 1 | US10358446, Compound 3)
Show SMILES C=CC(=O)N1CC[C@H](C1)n1c2ccncc2n(-c2ccc(Oc3ccccc3)cc2)c1=O
Show InChI InChI=1S/C25H22N4O3/c1-2-24(30)27-15-13-19(17-27)29-22-12-14-26-16-23(22)28(25(29)31)18-8-10-21(11-9-18)32-20-6-4-3-5-7-20/h2-12,14,16,19H,1,13,15,17H2/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM408593
PNG
(US10358446, Compound 31)
Show SMILES C=CC(=O)N1CCC(CC1)n1c2ccncc2n(-c2ccc(Oc3ccccc3)cc2)c1=O
Show InChI InChI=1S/C26H24N4O3/c1-2-25(31)28-16-13-20(14-17-28)29-23-12-15-27-18-24(23)30(26(29)32)19-8-10-22(11-9-19)33-21-6-4-3-5-7-21/h2-12,15,18,20H,1,13-14,16-17H2
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM408592
PNG
(US10358446, Compound 26)
Show SMILES CC(C)Oc1cccc(Oc2ccc(cc2)-n2c3cnccc3n([C@@H]3CCN(C3)C(=O)C=C)c2=O)c1
Show InChI InChI=1S/C28H28N4O4/c1-4-27(33)30-15-13-21(18-30)32-25-12-14-29-17-26(25)31(28(32)34)20-8-10-22(11-9-20)36-24-7-5-6-23(16-24)35-19(2)3/h4-12,14,16-17,19,21H,1,13,15,18H2,2-3H3/t21-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM408597
PNG
(US10358446, Compound 103)
Show SMILES Fc1cccc(Oc2ccc(cc2)-n2c3cnccc3n([C@@H]3CCN(C3)C(=O)C=C)c2=O)c1Cl
Show InChI InChI=1S/C25H20ClFN4O3/c1-2-23(32)29-13-11-17(15-29)31-20-10-12-28-14-21(20)30(25(31)33)16-6-8-18(9-7-16)34-22-5-3-4-19(27)24(22)26/h2-10,12,14,17H,1,11,13,15H2/t17-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM408588
PNG
(US10358446, Compound 4)
Show SMILES Cc1cccc(Oc2ccc(cc2)-n2c3cnccc3n([C@@H]3CCN(C3)C(=O)C=C)c2=O)c1
Show InChI InChI=1S/C26H24N4O3/c1-3-25(31)28-14-12-20(17-28)30-23-11-13-27-16-24(23)29(26(30)32)19-7-9-21(10-8-19)33-22-6-4-5-18(2)15-22/h3-11,13,15-16,20H,1,12,14,17H2,2H3/t20-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM408591
PNG
(US10358446, Compound 20)
Show SMILES Cc1cccc(Oc2ccc(cc2Cl)-n2c3cnccc3n([C@@H]3CCN(C3)C(=O)C=C)c2=O)c1
Show InChI InChI=1S/C26H23ClN4O3/c1-3-25(32)29-12-10-19(16-29)31-22-9-11-28-15-23(22)30(26(31)33)18-7-8-24(21(27)14-18)34-20-6-4-5-17(2)13-20/h3-9,11,13-15,19H,1,10,12,16H2,2H3/t19-/m1/s1
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n/an/a 5.50E+3n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM408588
PNG
(US10358446, Compound 4)
Show SMILES Cc1cccc(Oc2ccc(cc2)-n2c3cnccc3n([C@@H]3CCN(C3)C(=O)C=C)c2=O)c1
Show InChI InChI=1S/C26H24N4O3/c1-3-25(31)28-14-12-20(17-28)30-23-11-13-27-16-24(23)29(26(30)32)19-7-9-21(10-8-19)33-22-6-4-5-18(2)15-22/h3-11,13,15-16,20H,1,12,14,17H2,2H3/t20-/m1/s1
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n/an/a 5.50E+3n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM408590
PNG
(US10358446, Compound 8)
Show SMILES COc1cccc(Oc2ccc(cc2)-n2c3cnccc3n([C@H]3CCCN(C3)C(=O)C=C)c2=O)c1Cl
Show InChI InChI=1S/C27H25ClN4O4/c1-3-25(33)30-15-5-6-19(17-30)32-21-13-14-29-16-22(21)31(27(32)34)18-9-11-20(12-10-18)36-24-8-4-7-23(35-2)26(24)28/h3-4,7-14,16,19H,1,5-6,15,17H2,2H3/t19-/m0/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM408592
PNG
(US10358446, Compound 26)
Show SMILES CC(C)Oc1cccc(Oc2ccc(cc2)-n2c3cnccc3n([C@@H]3CCN(C3)C(=O)C=C)c2=O)c1
Show InChI InChI=1S/C28H28N4O4/c1-4-27(33)30-15-13-21(18-30)32-25-12-14-29-17-26(25)31(28(32)34)20-8-10-22(11-9-20)36-24-7-5-6-23(16-24)35-19(2)3/h4-12,14,16-17,19,21H,1,13,15,18H2,2-3H3/t21-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM408585
PNG
(US10358446, Compound 1 | US10358446, Compound 3)
Show SMILES C=CC(=O)N1CC[C@H](C1)n1c2ccncc2n(-c2ccc(Oc3ccccc3)cc2)c1=O
Show InChI InChI=1S/C25H22N4O3/c1-2-24(30)27-15-13-19(17-27)29-22-12-14-26-16-23(22)28(25(29)31)18-8-10-21(11-9-18)32-20-6-4-3-5-7-20/h2-12,14,16,19H,1,13,15,17H2/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM408594
PNG
(US10358446, Compound 38)
Show SMILES Clc1ccc(Oc2ccc(cc2)-n2c3cnccc3n([C@@H]3CCN(C3)C(=O)C=C)c2=O)cc1Cl
Show InChI InChI=1S/C25H20Cl2N4O3/c1-2-24(32)29-12-10-17(15-29)31-22-9-11-28-14-23(22)30(25(31)33)16-3-5-18(6-4-16)34-19-7-8-20(26)21(27)13-19/h2-9,11,13-14,17H,1,10,12,15H2/t17-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM408604
PNG
(US10358446, Compound 132)
Show SMILES COc1ccc(Oc2ccc(cc2)-n2c3cnccc3n(-c3cccc(NC(=O)C=C)c3)c2=O)cc1OC
Show InChI InChI=1S/C29H24N4O5/c1-4-28(34)31-19-6-5-7-21(16-19)33-24-14-15-30-18-25(24)32(29(33)35)20-8-10-22(11-9-20)38-23-12-13-26(36-2)27(17-23)37-3/h4-18H,1H2,2-3H3,(H,31,34)
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM408598
PNG
(US10358446, Compound 128)
Show SMILES Fc1cc(F)cc(Oc2ccc(cc2)-n2c3cnccc3n(-c3cccc(NC(=O)C=C)c3)c2=O)c1
Show InChI InChI=1S/C27H18F2N4O3/c1-2-26(34)31-19-4-3-5-21(15-19)33-24-10-11-30-16-25(24)32(27(33)35)20-6-8-22(9-7-20)36-23-13-17(28)12-18(29)14-23/h2-16H,1H2,(H,31,34)
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM408597
PNG
(US10358446, Compound 103)
Show SMILES Fc1cccc(Oc2ccc(cc2)-n2c3cnccc3n([C@@H]3CCN(C3)C(=O)C=C)c2=O)c1Cl
Show InChI InChI=1S/C25H20ClFN4O3/c1-2-23(32)29-13-11-17(15-29)31-20-10-12-28-14-21(20)30(25(31)33)16-6-8-18(9-7-16)34-22-5-3-4-19(27)24(22)26/h2-10,12,14,17H,1,11,13,15H2/t17-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM408594
PNG
(US10358446, Compound 38)
Show SMILES Clc1ccc(Oc2ccc(cc2)-n2c3cnccc3n([C@@H]3CCN(C3)C(=O)C=C)c2=O)cc1Cl
Show InChI InChI=1S/C25H20Cl2N4O3/c1-2-24(32)29-12-10-17(15-29)31-22-9-11-28-14-23(22)30(25(31)33)16-3-5-18(6-4-16)34-19-7-8-20(26)21(27)13-19/h2-9,11,13-14,17H,1,10,12,15H2/t17-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM408598
PNG
(US10358446, Compound 128)
Show SMILES Fc1cc(F)cc(Oc2ccc(cc2)-n2c3cnccc3n(-c3cccc(NC(=O)C=C)c3)c2=O)c1
Show InChI InChI=1S/C27H18F2N4O3/c1-2-26(34)31-19-4-3-5-21(15-19)33-24-10-11-30-16-25(24)32(27(33)35)20-6-8-22(9-7-20)36-23-13-17(28)12-18(29)14-23/h2-16H,1H2,(H,31,34)
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM408605
PNG
(US10358446, Compound 133)
Show SMILES Fc1cc(ccc1Oc1ccccc1)-n1c2cnccc2n(-c2cccc(NC(=O)C=C)c2)c1=O
Show InChI InChI=1S/C27H19FN4O3/c1-2-26(33)30-18-7-6-8-19(15-18)31-23-13-14-29-17-24(23)32(27(31)34)20-11-12-25(22(28)16-20)35-21-9-4-3-5-10-21/h2-17H,1H2,(H,30,33)
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM408585
PNG
(US10358446, Compound 1 | US10358446, Compound 3)
Show SMILES C=CC(=O)N1CC[C@H](C1)n1c2ccncc2n(-c2ccc(Oc3ccccc3)cc2)c1=O
Show InChI InChI=1S/C25H22N4O3/c1-2-24(30)27-15-13-19(17-27)29-22-12-14-26-16-23(22)28(25(29)31)18-8-10-21(11-9-18)32-20-6-4-3-5-7-20/h2-12,14,16,19H,1,13,15,17H2/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM408585
PNG
(US10358446, Compound 1 | US10358446, Compound 3)
Show SMILES C=CC(=O)N1CC[C@H](C1)n1c2ccncc2n(-c2ccc(Oc3ccccc3)cc2)c1=O
Show InChI InChI=1S/C25H22N4O3/c1-2-24(30)27-15-13-19(17-27)29-22-12-14-26-16-23(22)28(25(29)31)18-8-10-21(11-9-18)32-20-6-4-3-5-7-20/h2-12,14,16,19H,1,13,15,17H2/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM408596
PNG
(US10358446, Compound 60)
Show SMILES Fc1c(Cl)cccc1Oc1ccc(cc1)-n1c2cnccc2n([C@@H]2CCCN(C2)C(=O)C=C)c1=O
Show InChI InChI=1S/C26H22ClFN4O3/c1-2-24(33)30-14-4-5-18(16-30)32-21-12-13-29-15-22(21)31(26(32)34)17-8-10-19(11-9-17)35-23-7-3-6-20(27)25(23)28/h2-3,6-13,15,18H,1,4-5,14,16H2/t18-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM408586
PNG
(US10358446, Compound 2)
Show SMILES COc1cccc(Oc2ccc(cc2)-n2c3cnccc3n([C@@H]3CCN(C3)C(=O)C=C)c2=O)c1
Show InChI InChI=1S/C26H24N4O4/c1-3-25(31)28-14-12-19(17-28)30-23-11-13-27-16-24(23)29(26(30)32)18-7-9-20(10-8-18)34-22-6-4-5-21(15-22)33-2/h3-11,13,15-16,19H,1,12,14,17H2,2H3/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM408593
PNG
(US10358446, Compound 31)
Show SMILES C=CC(=O)N1CCC(CC1)n1c2ccncc2n(-c2ccc(Oc3ccccc3)cc2)c1=O
Show InChI InChI=1S/C26H24N4O3/c1-2-25(31)28-16-13-20(14-17-28)29-23-12-15-27-18-24(23)30(26(29)32)19-8-10-22(11-9-19)33-21-6-4-3-5-7-21/h2-12,15,18,20H,1,13-14,16-17H2
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM408595
PNG
(US10358446, Compound 51)
Show SMILES Fc1cc(ccc1Oc1cccc(Cl)c1)-n1c2cnccc2n(-c2cccc(NC(=O)C=C)c2)c1=O
Show InChI InChI=1S/C27H18ClFN4O3/c1-2-26(34)31-18-6-4-7-19(14-18)32-23-11-12-30-16-24(23)33(27(32)35)20-9-10-25(22(29)15-20)36-21-8-3-5-17(28)13-21/h2-16H,1H2,(H,31,34)
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM408589
PNG
(US10358446, Compound 5)
Show SMILES Clc1cc(ccc1Oc1ccccc1)-n1c2cnccc2n([C@@H]2CCN(C2)C(=O)C=C)c1=O
Show InChI InChI=1S/C25H21ClN4O3/c1-2-24(31)28-13-11-18(16-28)30-21-10-12-27-15-22(21)29(25(30)32)17-8-9-23(20(26)14-17)33-19-6-4-3-5-7-19/h2-10,12,14-15,18H,1,11,13,16H2/t18-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM408606
PNG
(US10358446, Compound 138)
Show SMILES COc1c(F)cccc1Oc1ccc(cc1)-n1c2cnccc2n([C@@H]2CCN(C2)C(=O)C=C)c1=O
Show InChI InChI=1S/C26H23FN4O4/c1-3-24(32)29-14-12-18(16-29)31-21-11-13-28-15-22(21)30(26(31)33)17-7-9-19(10-8-17)35-23-6-4-5-20(27)25(23)34-2/h3-11,13,15,18H,1,12,14,16H2,2H3/t18-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM408595
PNG
(US10358446, Compound 51)
Show SMILES Fc1cc(ccc1Oc1cccc(Cl)c1)-n1c2cnccc2n(-c2cccc(NC(=O)C=C)c2)c1=O
Show InChI InChI=1S/C27H18ClFN4O3/c1-2-26(34)31-18-6-4-7-19(14-18)32-23-11-12-30-16-24(23)33(27(32)35)20-9-10-25(22(29)15-20)36-21-8-3-5-17(28)13-21/h2-16H,1H2,(H,31,34)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM408596
PNG
(US10358446, Compound 60)
Show SMILES Fc1c(Cl)cccc1Oc1ccc(cc1)-n1c2cnccc2n([C@@H]2CCCN(C2)C(=O)C=C)c1=O
Show InChI InChI=1S/C26H22ClFN4O3/c1-2-24(33)30-14-4-5-18(16-30)32-21-12-13-29-15-22(21)31(26(32)34)17-8-10-19(11-9-17)35-23-7-3-6-20(27)25(23)28/h2-3,6-13,15,18H,1,4-5,14,16H2/t18-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM408586
PNG
(US10358446, Compound 2)
Show SMILES COc1cccc(Oc2ccc(cc2)-n2c3cnccc3n([C@@H]3CCN(C3)C(=O)C=C)c2=O)c1
Show InChI InChI=1S/C26H24N4O4/c1-3-25(31)28-14-12-19(17-28)30-23-11-13-27-16-24(23)29(26(30)32)18-7-9-20(10-8-18)34-22-6-4-5-21(15-22)33-2/h3-11,13,15-16,19H,1,12,14,17H2,2H3/t19-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM408604
PNG
(US10358446, Compound 132)
Show SMILES COc1ccc(Oc2ccc(cc2)-n2c3cnccc3n(-c3cccc(NC(=O)C=C)c3)c2=O)cc1OC
Show InChI InChI=1S/C29H24N4O5/c1-4-28(34)31-19-6-5-7-21(16-19)33-24-14-15-30-18-25(24)32(29(33)35)20-8-10-22(11-9-20)38-23-12-13-26(36-2)27(17-23)37-3/h4-18H,1H2,2-3H3,(H,31,34)
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n/an/a>1.00E+4n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM408606
PNG
(US10358446, Compound 138)
Show SMILES COc1c(F)cccc1Oc1ccc(cc1)-n1c2cnccc2n([C@@H]2CCN(C2)C(=O)C=C)c1=O
Show InChI InChI=1S/C26H23FN4O4/c1-3-24(32)29-14-12-18(16-29)31-21-11-13-28-15-22(21)30(26(31)33)17-7-9-19(10-8-17)35-23-6-4-5-20(27)25(23)34-2/h3-11,13,15,18H,1,12,14,16H2,2H3/t18-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM408591
PNG
(US10358446, Compound 20)
Show SMILES Cc1cccc(Oc2ccc(cc2Cl)-n2c3cnccc3n([C@@H]3CCN(C3)C(=O)C=C)c2=O)c1
Show InChI InChI=1S/C26H23ClN4O3/c1-3-25(32)29-12-10-19(16-29)31-22-9-11-28-15-23(22)30(26(31)33)18-7-8-24(21(27)14-18)34-20-6-4-5-17(2)13-20/h3-9,11,13-15,19H,1,10,12,16H2,2H3/t19-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM408605
PNG
(US10358446, Compound 133)
Show SMILES Fc1cc(ccc1Oc1ccccc1)-n1c2cnccc2n(-c2cccc(NC(=O)C=C)c2)c1=O
Show InChI InChI=1S/C27H19FN4O3/c1-2-26(33)30-18-7-6-8-19(15-18)31-23-13-14-29-17-24(23)32(27(31)34)20-11-12-25(22(28)16-20)35-21-9-4-3-5-10-21/h2-17H,1H2,(H,30,33)
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM408589
PNG
(US10358446, Compound 5)
Show SMILES Clc1cc(ccc1Oc1ccccc1)-n1c2cnccc2n([C@@H]2CCN(C2)C(=O)C=C)c1=O
Show InChI InChI=1S/C25H21ClN4O3/c1-2-24(31)28-13-11-18(16-28)30-21-10-12-27-15-22(21)29(25(30)32)17-8-9-23(20(26)14-17)33-19-6-4-3-5-7-19/h2-10,12,14-15,18H,1,11,13,16H2/t18-/m1/s1
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ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM408590
PNG
(US10358446, Compound 8)
Show SMILES COc1cccc(Oc2ccc(cc2)-n2c3cnccc3n([C@H]3CCCN(C3)C(=O)C=C)c2=O)c1Cl
Show InChI InChI=1S/C27H25ClN4O4/c1-3-25(33)30-15-5-6-19(17-30)32-21-13-14-29-16-22(21)31(27(32)34)18-9-11-20(12-10-18)36-24-8-4-7-23(35-2)26(24)28/h3-4,7-14,16,19H,1,5-6,15,17H2,2H3/t19-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...


US Patent US10358446 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K4R
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%