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Patent code US10358449

Compile Data Set for Download or QSAR
Found 5 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM408611
PNG
(US10358449, Compound I-3)
Show SMILES CC#CCn1c(nc2n(C)c(=O)n(Cc3nccnc3C#N)c(=O)c12)N1CCC[C@@H](N)C1
Show InChI InChI=1S/C21H23N9O2/c1-3-4-10-29-17-18(26-20(29)28-9-5-6-14(23)12-28)27(2)21(32)30(19(17)31)13-16-15(11-22)24-7-8-25-16/h7-8,14H,5-6,9-10,12-13,23H2,1-2H3/t14-/m1/s1
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US Patent
n/an/a 0.0800n/an/an/an/an/an/a



Jiangsu Tasly Diyi Pharmaceutical Co, LTD.

US Patent


Assay Description
DPP-IV could hydrolyze Gly-Pro-Aminoluciferin at room temperature to generate Aminoluciferin, which could produce “glow type” luminescent signals in ...


US Patent US10358449 (2019)


BindingDB Entry DOI: 10.7270/Q29S1TCK
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50228403
PNG
((R)-8-(3-aminopiperidin-1-yl)-7-(but-2-ynyl)-3-met...)
Show SMILES CC#CCn1c(nc2n(C)c(=O)n(Cc3nc(C)c4ccccc4n3)c(=O)c12)N1CCC[C@@H](N)C1
Show InChI InChI=1S/C25H28N8O2/c1-4-5-13-32-21-22(29-24(32)31-12-8-9-17(26)14-31)30(3)25(35)33(23(21)34)15-20-27-16(2)18-10-6-7-11-19(18)28-20/h6-7,10-11,17H,8-9,12-15,26H2,1-3H3/t17-/m1/s1
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Patents


Similars

DrugBank
MMDB
PDB
US Patent
n/an/a 0.210n/an/an/an/an/an/a



Jiangsu Tasly Diyi Pharmaceutical Co, LTD.

US Patent


Assay Description
DPP-IV could hydrolyze Gly-Pro-Aminoluciferin at room temperature to generate Aminoluciferin, which could produce “glow type” luminescent signals in ...


US Patent US10358449 (2019)


BindingDB Entry DOI: 10.7270/Q29S1TCK
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM408607
PNG
(US10358449, Compound I-1)
Show SMILES CC#CCn1c(nc2n(C)c(=O)n(Cc3cccc(F)c3C#N)c(=O)c12)N1CCC[C@@H](N)C1
Show InChI InChI=1S/C23H24FN7O2/c1-3-4-11-30-19-20(27-22(30)29-10-6-8-16(26)14-29)28(2)23(33)31(21(19)32)13-15-7-5-9-18(24)17(15)12-25/h5,7,9,16H,6,8,10-11,13-14,26H2,1-2H3/t16-/m1/s1
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n/an/a 0.210n/an/an/an/an/an/a



Jiangsu Tasly Diyi Pharmaceutical Co, LTD.

US Patent


Assay Description
DPP-IV could hydrolyze Gly-Pro-Aminoluciferin at room temperature to generate Aminoluciferin, which could produce “glow type” luminescent signals in ...


US Patent US10358449 (2019)


BindingDB Entry DOI: 10.7270/Q29S1TCK
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM408610
PNG
(US10358449, Compound I-2)
Show SMILES CC#CCn1c(nc2n(C)c(=O)n(Cc3cc(F)c(F)cc3C#N)c(=O)c12)N1CCC[C@@H](N)C1
Show InChI InChI=1S/C23H23F2N7O2/c1-3-4-8-31-19-20(28-22(31)30-7-5-6-16(27)13-30)29(2)23(34)32(21(19)33)12-15-10-18(25)17(24)9-14(15)11-26/h9-10,16H,5-8,12-13,27H2,1-2H3/t16-/m1/s1
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n/an/a 2.10n/an/an/an/an/an/a



Jiangsu Tasly Diyi Pharmaceutical Co, LTD.

US Patent


Assay Description
DPP-IV could hydrolyze Gly-Pro-Aminoluciferin at room temperature to generate Aminoluciferin, which could produce “glow type” luminescent signals in ...


US Patent US10358449 (2019)


BindingDB Entry DOI: 10.7270/Q29S1TCK
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM408612
PNG
(US10358449, Compound I-4)
Show SMILES COC(=O)c1cccnc1Cn1c(=O)n(C)c2nc(N3CCC[C@@H](N)C3)n(CC#CC)c2c1=O
Show InChI InChI=1S/C23H27N7O4/c1-4-5-12-29-18-19(26-22(29)28-11-7-8-15(24)13-28)27(2)23(33)30(20(18)31)14-17-16(21(32)34-3)9-6-10-25-17/h6,9-10,15H,7-8,11-14,24H2,1-3H3/t15-/m1/s1
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n/an/a 4.80n/an/an/an/an/an/a



Jiangsu Tasly Diyi Pharmaceutical Co, LTD.

US Patent


Assay Description
DPP-IV could hydrolyze Gly-Pro-Aminoluciferin at room temperature to generate Aminoluciferin, which could produce “glow type” luminescent signals in ...


US Patent US10358449 (2019)


BindingDB Entry DOI: 10.7270/Q29S1TCK
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%