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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Indoleamine 2,3-dioxygenase (Homo sapiens (Human)) | BDBM408630 (4-(2-(6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-h...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Innogate Pharma Co., Ltd. US Patent | Assay Description In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u... | US Patent US10358451 (2019) BindingDB Entry DOI: 10.7270/Q26112P0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Indoleamine 2,3-dioxygenase (Homo sapiens (Human)) | BDBM408633 (US10358451, Compound 18k-2) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Innogate Pharma Co., Ltd. US Patent | Assay Description In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u... | US Patent US10358451 (2019) BindingDB Entry DOI: 10.7270/Q26112P0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Indoleamine 2,3-dioxygenase (Homo sapiens (Human)) | BDBM408617 ((1s,3r,5R,7S)-3-(2-(6-fluoro-5H-imidazo[5,1-a]isoi...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Innogate Pharma Co., Ltd. US Patent | Assay Description In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u... | US Patent US10358451 (2019) BindingDB Entry DOI: 10.7270/Q26112P0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Indoleamine 2,3-dioxygenase (Homo sapiens (Human)) | BDBM408629 (1-((3r,5r,7r)-adamantan-1-yl)-2-(6-fluoro-5H-imida...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Innogate Pharma Co., Ltd. US Patent | Assay Description In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u... | US Patent US10358451 (2019) BindingDB Entry DOI: 10.7270/Q26112P0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Indoleamine 2,3-dioxygenase (Homo sapiens (Human)) | BDBM408616 (1s,3r,5R,7S)-3-(1-hydroxy-2-(5H-imidazo[5,1-a]isoi...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Innogate Pharma Co., Ltd. US Patent | Assay Description In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u... | US Patent US10358451 (2019) BindingDB Entry DOI: 10.7270/Q26112P0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Indoleamine 2,3-dioxygenase (Homo sapiens (Human)) | BDBM408626 (US10358451, Compound 15d-3) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Innogate Pharma Co., Ltd. US Patent | Assay Description In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u... | US Patent US10358451 (2019) BindingDB Entry DOI: 10.7270/Q26112P0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Indoleamine 2,3-dioxygenase (Homo sapiens (Human)) | BDBM408631 ((1R,2s,3S,5s,7s)-5-(2-(6-fluoro-5H-imidazo[5,1-a]i...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Innogate Pharma Co., Ltd. US Patent | Assay Description In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u... | US Patent US10358451 (2019) BindingDB Entry DOI: 10.7270/Q26112P0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tryptophan 2,3-dioxygenase (Homo sapiens (Human)) | BDBM408616 (1s,3r,5R,7S)-3-(1-hydroxy-2-(5H-imidazo[5,1-a]isoi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | <200 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Innogate Pharma Co., Ltd. US Patent | Assay Description In vitro TDO enzymatic activity was determined in a mixture of 50 mM potassium phosphate buffer, pH 6.5; 200 nM human TDO enzyme, 300 μM L-Trypt... | US Patent US10358451 (2019) BindingDB Entry DOI: 10.7270/Q26112P0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tryptophan 2,3-dioxygenase (Homo sapiens (Human)) | BDBM408614 (2-(5H-imidazo[5,1-a]isoindol-5-yl)-1-(1-(2-nitro-4...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | <200 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Innogate Pharma Co., Ltd. US Patent | Assay Description In vitro TDO enzymatic activity was determined in a mixture of 50 mM potassium phosphate buffer, pH 6.5; 200 nM human TDO enzyme, 300 μM L-Trypt... | US Patent US10358451 (2019) BindingDB Entry DOI: 10.7270/Q26112P0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tryptophan 2,3-dioxygenase (Homo sapiens (Human)) | BDBM408617 ((1s,3r,5R,7S)-3-(2-(6-fluoro-5H-imidazo[5,1-a]isoi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | <200 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Innogate Pharma Co., Ltd. US Patent | Assay Description In vitro TDO enzymatic activity was determined in a mixture of 50 mM potassium phosphate buffer, pH 6.5; 200 nM human TDO enzyme, 300 μM L-Trypt... | US Patent US10358451 (2019) BindingDB Entry DOI: 10.7270/Q26112P0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tryptophan 2,3-dioxygenase (Homo sapiens (Human)) | BDBM408631 ((1R,2s,3S,5s,7s)-5-(2-(6-fluoro-5H-imidazo[5,1-a]i...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | <200 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Innogate Pharma Co., Ltd. US Patent | Assay Description In vitro TDO enzymatic activity was determined in a mixture of 50 mM potassium phosphate buffer, pH 6.5; 200 nM human TDO enzyme, 300 μM L-Trypt... | US Patent US10358451 (2019) BindingDB Entry DOI: 10.7270/Q26112P0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tryptophan 2,3-dioxygenase (Homo sapiens (Human)) | BDBM408630 (4-(2-(6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-h...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | <200 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Innogate Pharma Co., Ltd. US Patent | Assay Description In vitro TDO enzymatic activity was determined in a mixture of 50 mM potassium phosphate buffer, pH 6.5; 200 nM human TDO enzyme, 300 μM L-Trypt... | US Patent US10358451 (2019) BindingDB Entry DOI: 10.7270/Q26112P0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Indoleamine 2,3-dioxygenase (Homo sapiens (Human)) | BDBM347015 (US10202388, Compound 13 | US10358451, Compound 10) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Innogate Pharma Co., Ltd. US Patent | Assay Description In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u... | US Patent US10358451 (2019) BindingDB Entry DOI: 10.7270/Q26112P0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tryptophan 2,3-dioxygenase (Homo sapiens (Human)) | BDBM408629 (1-((3r,5r,7r)-adamantan-1-yl)-2-(6-fluoro-5H-imida...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Innogate Pharma Co., Ltd. US Patent | Assay Description In vitro TDO enzymatic activity was determined in a mixture of 50 mM potassium phosphate buffer, pH 6.5; 200 nM human TDO enzyme, 300 μM L-Trypt... | US Patent US10358451 (2019) BindingDB Entry DOI: 10.7270/Q26112P0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Indoleamine 2,3-dioxygenase (Homo sapiens (Human)) | BDBM408614 (2-(5H-imidazo[5,1-a]isoindol-5-yl)-1-(1-(2-nitro-4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Innogate Pharma Co., Ltd. US Patent | Assay Description In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u... | US Patent US10358451 (2019) BindingDB Entry DOI: 10.7270/Q26112P0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Indoleamine 2,3-dioxygenase (Homo sapiens (Human)) | BDBM408622 (US10358451, Compound 15d-2) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | >500 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Innogate Pharma Co., Ltd. US Patent | Assay Description In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u... | US Patent US10358451 (2019) BindingDB Entry DOI: 10.7270/Q26112P0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Indoleamine 2,3-dioxygenase (Homo sapiens (Human)) | BDBM408632 (US10358451, Compound 18k-1) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | <500 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Innogate Pharma Co., Ltd. US Patent | Assay Description In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u... | US Patent US10358451 (2019) BindingDB Entry DOI: 10.7270/Q26112P0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Indoleamine 2,3-dioxygenase (Homo sapiens (Human)) | BDBM408628 (US10358451, Compound 15d-4) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | >500 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Innogate Pharma Co., Ltd. US Patent | Assay Description In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u... | US Patent US10358451 (2019) BindingDB Entry DOI: 10.7270/Q26112P0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Indoleamine 2,3-dioxygenase (Homo sapiens (Human)) | BDBM408618 (US10358451, Compound 15d-1) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | >500 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Innogate Pharma Co., Ltd. US Patent | Assay Description In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u... | US Patent US10358451 (2019) BindingDB Entry DOI: 10.7270/Q26112P0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
