BindingDB logo
myBDB logout

Patent code US10358451

Compile Data Set for Download or QSAR
Found 19 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM408630
PNG
(4-(2-(6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-h...)
Show SMILES OC(CC1c2c(cccc2F)-c2cncn12)C12CCC(O)(CC1)CC2
Show InChI InChI=1S/C20H23FN2O2/c21-14-3-1-2-13-16-11-22-12-23(16)15(18(13)14)10-17(24)19-4-7-20(25,8-5-19)9-6-19/h1-3,11-12,15,17,24-25H,4-10H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Hangzhou Innogate Pharma Co., Ltd.

US Patent


Assay Description
In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u...


US Patent US10358451 (2019)


BindingDB Entry DOI: 10.7270/Q26112P0
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM408633
PNG
(US10358451, Compound 18k-2)
Show SMILES OC(C[C@H]1c2c(cccc2F)-c2cncn12)C12CC3CC(CC(O)(C3)C1)C2
Show InChI InChI=1S/C22H25FN2O2/c23-16-3-1-2-15-18-10-24-12-25(18)17(20(15)16)5-19(26)21-6-13-4-14(7-21)9-22(27,8-13)11-21/h1-3,10,12-14,17,19,26-27H,4-9,11H2/t13?,14?,17-,19?,21?,22?/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Hangzhou Innogate Pharma Co., Ltd.

US Patent


Assay Description
In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u...


US Patent US10358451 (2019)


BindingDB Entry DOI: 10.7270/Q26112P0
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM408617
PNG
((1s,3r,5R,7S)-3-(2-(6-fluoro-5H-imidazo[5,1-a]isoi...)
Show SMILES OC12CC3CC(C1)CC(C3)(C2)C(=O)CC1c2c(cccc2F)-c2cncn12
Show InChI InChI=1S/C22H23FN2O2/c23-16-3-1-2-15-18-10-24-12-25(18)17(20(15)16)5-19(26)21-6-13-4-14(7-21)9-22(27,8-13)11-21/h1-3,10,12-14,17,27H,4-9,11H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Hangzhou Innogate Pharma Co., Ltd.

US Patent


Assay Description
In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u...


US Patent US10358451 (2019)


BindingDB Entry DOI: 10.7270/Q26112P0
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM408629
PNG
(1-((3r,5r,7r)-adamantan-1-yl)-2-(6-fluoro-5H-imida...)
Show SMILES Fc1cccc2-c3cncn3C(CC(=O)C34CC5CC(CC(C5)C3)C4)c12
Show InChI InChI=1S/C22H23FN2O/c23-17-3-1-2-16-19-11-24-12-25(19)18(21(16)17)7-20(26)22-8-13-4-14(9-22)6-15(5-13)10-22/h1-3,11-15,18H,4-10H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Hangzhou Innogate Pharma Co., Ltd.

US Patent


Assay Description
In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u...


US Patent US10358451 (2019)


BindingDB Entry DOI: 10.7270/Q26112P0
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM408616
PNG
(1s,3r,5R,7S)-3-(1-hydroxy-2-(5H-imidazo[5,1-a]isoi...)
Show SMILES OC12CC3CC(C1)CC(C3)(C2)C(=O)CC1c2ccccc2-c2cncn12
Show InChI InChI=1S/C22H24N2O2/c25-20(21-7-14-5-15(8-21)10-22(26,9-14)12-21)6-18-16-3-1-2-4-17(16)19-11-23-13-24(18)19/h1-4,11,13-15,18,26H,5-10,12H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Hangzhou Innogate Pharma Co., Ltd.

US Patent


Assay Description
In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u...


US Patent US10358451 (2019)


BindingDB Entry DOI: 10.7270/Q26112P0
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM408626
PNG
(US10358451, Compound 15d-3)
Show SMILES O[C@@]12CC3CC(C1)CC(C3)(C2)C(=O)C[C@H]1c2c(cccc2F)-c2cncn12
Show InChI InChI=1S/C22H23FN2O2/c23-16-3-1-2-15-18-10-24-12-25(18)17(20(15)16)5-19(26)21-6-13-4-14(7-21)9-22(27,8-13)11-21/h1-3,10,12-14,17,27H,4-9,11H2/t13?,14?,17-,21?,22-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Hangzhou Innogate Pharma Co., Ltd.

US Patent


Assay Description
In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u...


US Patent US10358451 (2019)


BindingDB Entry DOI: 10.7270/Q26112P0
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM408631
PNG
((1R,2s,3S,5s,7s)-5-(2-(6-fluoro-5H-imidazo[5,1-a]i...)
Show SMILES OC1C2CC3CC1CC(C3)(C2)C(=O)CC1c2c(cccc2F)-c2cncn12
Show InChI InChI=1S/C22H23FN2O2/c23-16-3-1-2-15-18-10-24-11-25(18)17(20(15)16)6-19(26)22-7-12-4-13(8-22)21(27)14(5-12)9-22/h1-3,10-14,17,21,27H,4-9H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Hangzhou Innogate Pharma Co., Ltd.

US Patent


Assay Description
In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u...


US Patent US10358451 (2019)


BindingDB Entry DOI: 10.7270/Q26112P0
More data for this
Ligand-Target Pair
Tryptophan 2,3-dioxygenase


(Homo sapiens (Human))
BDBM408616
PNG
(1s,3r,5R,7S)-3-(1-hydroxy-2-(5H-imidazo[5,1-a]isoi...)
Show SMILES OC12CC3CC(C1)CC(C3)(C2)C(=O)CC1c2ccccc2-c2cncn12
Show InChI InChI=1S/C22H24N2O2/c25-20(21-7-14-5-15(8-21)10-22(26,9-14)12-21)6-18-16-3-1-2-4-17(16)19-11-23-13-24(18)19/h1-4,11,13-15,18,26H,5-10,12H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



Hangzhou Innogate Pharma Co., Ltd.

US Patent


Assay Description
In vitro TDO enzymatic activity was determined in a mixture of 50 mM potassium phosphate buffer, pH 6.5; 200 nM human TDO enzyme, 300 μM L-Trypt...


US Patent US10358451 (2019)


BindingDB Entry DOI: 10.7270/Q26112P0
More data for this
Ligand-Target Pair
Tryptophan 2,3-dioxygenase


(Homo sapiens (Human))
BDBM408614
PNG
(2-(5H-imidazo[5,1-a]isoindol-5-yl)-1-(1-(2-nitro-4...)
Show SMILES OC(CC1c2ccccc2-c2cncn12)C1CCN(CC1)c1ccc(cc1[N+]([O-])=O)C(F)(F)F
Show InChI InChI=1S/C24H23F3N4O3/c25-24(26,27)16-5-6-19(21(11-16)31(33)34)29-9-7-15(8-10-29)23(32)12-20-17-3-1-2-4-18(17)22-13-28-14-30(20)22/h1-6,11,13-15,20,23,32H,7-10,12H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



Hangzhou Innogate Pharma Co., Ltd.

US Patent


Assay Description
In vitro TDO enzymatic activity was determined in a mixture of 50 mM potassium phosphate buffer, pH 6.5; 200 nM human TDO enzyme, 300 μM L-Trypt...


US Patent US10358451 (2019)


BindingDB Entry DOI: 10.7270/Q26112P0
More data for this
Ligand-Target Pair
Tryptophan 2,3-dioxygenase


(Homo sapiens (Human))
BDBM408617
PNG
((1s,3r,5R,7S)-3-(2-(6-fluoro-5H-imidazo[5,1-a]isoi...)
Show SMILES OC12CC3CC(C1)CC(C3)(C2)C(=O)CC1c2c(cccc2F)-c2cncn12
Show InChI InChI=1S/C22H23FN2O2/c23-16-3-1-2-15-18-10-24-12-25(18)17(20(15)16)5-19(26)21-6-13-4-14(7-21)9-22(27,8-13)11-21/h1-3,10,12-14,17,27H,4-9,11H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



Hangzhou Innogate Pharma Co., Ltd.

US Patent


Assay Description
In vitro TDO enzymatic activity was determined in a mixture of 50 mM potassium phosphate buffer, pH 6.5; 200 nM human TDO enzyme, 300 μM L-Trypt...


US Patent US10358451 (2019)


BindingDB Entry DOI: 10.7270/Q26112P0
More data for this
Ligand-Target Pair
Tryptophan 2,3-dioxygenase


(Homo sapiens (Human))
BDBM408631
PNG
((1R,2s,3S,5s,7s)-5-(2-(6-fluoro-5H-imidazo[5,1-a]i...)
Show SMILES OC1C2CC3CC1CC(C3)(C2)C(=O)CC1c2c(cccc2F)-c2cncn12
Show InChI InChI=1S/C22H23FN2O2/c23-16-3-1-2-15-18-10-24-11-25(18)17(20(15)16)6-19(26)22-7-12-4-13(8-22)21(27)14(5-12)9-22/h1-3,10-14,17,21,27H,4-9H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



Hangzhou Innogate Pharma Co., Ltd.

US Patent


Assay Description
In vitro TDO enzymatic activity was determined in a mixture of 50 mM potassium phosphate buffer, pH 6.5; 200 nM human TDO enzyme, 300 μM L-Trypt...


US Patent US10358451 (2019)


BindingDB Entry DOI: 10.7270/Q26112P0
More data for this
Ligand-Target Pair
Tryptophan 2,3-dioxygenase


(Homo sapiens (Human))
BDBM408630
PNG
(4-(2-(6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-h...)
Show SMILES OC(CC1c2c(cccc2F)-c2cncn12)C12CCC(O)(CC1)CC2
Show InChI InChI=1S/C20H23FN2O2/c21-14-3-1-2-13-16-11-22-12-23(16)15(18(13)14)10-17(24)19-4-7-20(25,8-5-19)9-6-19/h1-3,11-12,15,17,24-25H,4-10H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



Hangzhou Innogate Pharma Co., Ltd.

US Patent


Assay Description
In vitro TDO enzymatic activity was determined in a mixture of 50 mM potassium phosphate buffer, pH 6.5; 200 nM human TDO enzyme, 300 μM L-Trypt...


US Patent US10358451 (2019)


BindingDB Entry DOI: 10.7270/Q26112P0
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM347015
PNG
(US10202388, Compound 13 | US10358451, Compound 10)
Show SMILES OC(CC1c2ccccc2-c2cncn12)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H26N2O/c25-21(22-9-14-5-15(10-22)7-16(6-14)11-22)8-19-17-3-1-2-4-18(17)20-12-23-13-24(19)20/h1-4,12-16,19,21,25H,5-11H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Hangzhou Innogate Pharma Co., Ltd.

US Patent


Assay Description
In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u...


US Patent US10358451 (2019)


BindingDB Entry DOI: 10.7270/Q26112P0
More data for this
Ligand-Target Pair
Tryptophan 2,3-dioxygenase


(Homo sapiens (Human))
BDBM408629
PNG
(1-((3r,5r,7r)-adamantan-1-yl)-2-(6-fluoro-5H-imida...)
Show SMILES Fc1cccc2-c3cncn3C(CC(=O)C34CC5CC(CC(C5)C3)C4)c12
Show InChI InChI=1S/C22H23FN2O/c23-17-3-1-2-16-19-11-24-12-25(19)18(21(16)17)7-20(26)22-8-13-4-14(9-22)6-15(5-13)10-22/h1-3,11-15,18H,4-10H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Hangzhou Innogate Pharma Co., Ltd.

US Patent


Assay Description
In vitro TDO enzymatic activity was determined in a mixture of 50 mM potassium phosphate buffer, pH 6.5; 200 nM human TDO enzyme, 300 μM L-Trypt...


US Patent US10358451 (2019)


BindingDB Entry DOI: 10.7270/Q26112P0
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM408614
PNG
(2-(5H-imidazo[5,1-a]isoindol-5-yl)-1-(1-(2-nitro-4...)
Show SMILES OC(CC1c2ccccc2-c2cncn12)C1CCN(CC1)c1ccc(cc1[N+]([O-])=O)C(F)(F)F
Show InChI InChI=1S/C24H23F3N4O3/c25-24(26,27)16-5-6-19(21(11-16)31(33)34)29-9-7-15(8-10-29)23(32)12-20-17-3-1-2-4-18(17)22-13-28-14-30(20)22/h1-6,11,13-15,20,23,32H,7-10,12H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Hangzhou Innogate Pharma Co., Ltd.

US Patent


Assay Description
In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u...


US Patent US10358451 (2019)


BindingDB Entry DOI: 10.7270/Q26112P0
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM408622
PNG
(US10358451, Compound 15d-2)
Show SMILES O[C@@]12CC3CC(C1)CC(C3)(C2)C(=O)C[C@@H]1c2c(cccc2F)-c2cncn12
Show InChI InChI=1S/C22H23FN2O2/c23-16-3-1-2-15-18-10-24-12-25(18)17(20(15)16)5-19(26)21-6-13-4-14(7-21)9-22(27,8-13)11-21/h1-3,10,12-14,17,27H,4-9,11H2/t13?,14?,17-,21?,22-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>500n/an/an/an/an/an/a



Hangzhou Innogate Pharma Co., Ltd.

US Patent


Assay Description
In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u...


US Patent US10358451 (2019)


BindingDB Entry DOI: 10.7270/Q26112P0
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM408632
PNG
(US10358451, Compound 18k-1)
Show SMILES OC(C[C@@H]1c2c(cccc2F)-c2cncn12)C12CC3CC(CC(O)(C3)C1)C2
Show InChI InChI=1S/C22H25FN2O2/c23-16-3-1-2-15-18-10-24-12-25(18)17(20(15)16)5-19(26)21-6-13-4-14(7-21)9-22(27,8-13)11-21/h1-3,10,12-14,17,19,26-27H,4-9,11H2/t13?,14?,17-,19?,21?,22?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Hangzhou Innogate Pharma Co., Ltd.

US Patent


Assay Description
In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u...


US Patent US10358451 (2019)


BindingDB Entry DOI: 10.7270/Q26112P0
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM408628
PNG
(US10358451, Compound 15d-4)
Show SMILES O[C@@]12CC3CC(C1)CC(C3)(C2)C(=O)C[C@@H]1c2c(cccc2F)-c2cncn12
Show InChI InChI=1S/C22H23FN2O2/c23-16-3-1-2-15-18-10-24-12-25(18)17(20(15)16)5-19(26)21-6-13-4-14(7-21)9-22(27,8-13)11-21/h1-3,10,12-14,17,27H,4-9,11H2/t13?,14?,17-,21?,22-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>500n/an/an/an/an/an/a



Hangzhou Innogate Pharma Co., Ltd.

US Patent


Assay Description
In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u...


US Patent US10358451 (2019)


BindingDB Entry DOI: 10.7270/Q26112P0
More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM408618
PNG
(US10358451, Compound 15d-1)
Show SMILES O[C@@]12CC3CC(C1)CC(C3)(C2)C(=O)C[C@H]1c2c(cccc2F)-c2cncn12
Show InChI InChI=1S/C22H23FN2O2/c23-16-3-1-2-15-18-10-24-12-25(18)17(20(15)16)5-19(26)21-6-13-4-14(7-21)9-22(27,8-13)11-21/h1-3,10,12-14,17,27H,4-9,11H2/t13?,14?,17-,21?,22-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>500n/an/an/an/an/an/a



Hangzhou Innogate Pharma Co., Ltd.

US Patent


Assay Description
In vitro IDO1 enzymatic activity was determined in a mixture of 50 mM MES buffer at pH 6.5; 200 nM human IDO enzyme, 150 μM L-Tryptophan, 2250 u...


US Patent US10358451 (2019)


BindingDB Entry DOI: 10.7270/Q26112P0
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%