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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM408664 ((R)-5-cyano-4-ethoxy-N-(1-(2-hydroxy-2-(4-methyl-1...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangsu Hengrui Medicine Co., Ltd. US Patent | Assay Description The Inhibitory Activity of the Present Compounds on Human ROMK and Rat ROMK ChannelsThe method described hereafter was used for determining the inhib... | US Patent US10364234 (2019) BindingDB Entry DOI: 10.7270/Q2P271GV | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM408663 ((R)-5-cyano-N-(1-(2-hydroxy-2-(4-methyl-1-oxo-1,3-...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangsu Hengrui Medicine Co., Ltd. US Patent | Assay Description The Inhibitory Activity of the Present Compounds on Human ROMK and Rat ROMK ChannelsThe method described hereafter was used for determining the inhib... | US Patent US10364234 (2019) BindingDB Entry DOI: 10.7270/Q2P271GV | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Renal Outer Medullary Potassium (ROMK) (Rattus norvegicus (Rat)) | BDBM408664 ((R)-5-cyano-4-ethoxy-N-(1-(2-hydroxy-2-(4-methyl-1...) | Reactome pathway UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 89 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangsu Hengrui Medicine Co., Ltd. US Patent | Assay Description The Inhibitory Activity of the Present Compounds on Human ROMK and Rat ROMK ChannelsThe method described hereafter was used for determining the inhib... | US Patent US10364234 (2019) BindingDB Entry DOI: 10.7270/Q2P271GV | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Renal Outer Medullary Potassium (ROMK) (Rattus norvegicus (Rat)) | BDBM408663 ((R)-5-cyano-N-(1-(2-hydroxy-2-(4-methyl-1-oxo-1,3-...) | Reactome pathway UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 192 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangsu Hengrui Medicine Co., Ltd. US Patent | Assay Description The Inhibitory Activity of the Present Compounds on Human ROMK and Rat ROMK ChannelsThe method described hereafter was used for determining the inhib... | US Patent US10364234 (2019) BindingDB Entry DOI: 10.7270/Q2P271GV | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM408663 ((R)-5-cyano-N-(1-(2-hydroxy-2-(4-methyl-1-oxo-1,3-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.37E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Jiangsu Hengrui Medicine Co., Ltd. US Patent | Assay Description The method described hereafter is used for determining the inhibitory activity of the present compounds on hERG1. Materials and Instruments(1) FluxOR... | US Patent US10364234 (2019) BindingDB Entry DOI: 10.7270/Q2P271GV | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
