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Patent code US10364238

Compile Data Set for Download or QSAR
Found 188 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Plasma kallikrein


(Homo sapiens (Human))
BDBM408768
PNG
(N-[(6-cyano-2-fluoro-3-methoxyphenyl)methyl]-3-(me...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1c(F)c(OC)ccc1C#N
Show InChI InChI=1S/C28H26FN5O4/c1-37-18-24-23(28(36)31-14-22-21(13-30)10-11-25(38-2)27(22)29)17-34(32-24)16-20-8-6-19(7-9-20)15-33-12-4-3-5-26(33)35/h3-12,17H,14-16,18H2,1-2H3,(H,31,36)
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n/an/a 0.600n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408736
PNG
( N-[(2-fluoro-3,6-dimethoxyphenyl)methyl]-3-(metho...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1c(OC)ccc(OC)c1F
Show InChI InChI=1S/C28H29FN4O5/c1-36-18-23-22(28(35)30-14-21-24(37-2)11-12-25(38-3)27(21)29)17-33(31-23)16-20-9-7-19(8-10-20)15-32-13-5-4-6-26(32)34/h4-13,17H,14-16,18H2,1-3H3,(H,30,35)
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n/an/a 2.10n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408773
PNG
( N-{[2-(difluoromethyl)-5-methoxyphenyl]methyl}-3-...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cc(OC)ccc1C(F)F
Show InChI InChI=1S/C28H28F2N4O4/c1-37-18-25-24(28(36)31-14-21-13-22(38-2)10-11-23(21)27(29)30)17-34(32-25)16-20-8-6-19(7-9-20)15-33-12-4-3-5-26(33)35/h3-13,17,27H,14-16,18H2,1-2H3,(H,31,36)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408717
PNG
( N-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-3-(met...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1nccc(OC)c1F
Show InChI InChI=1S/C26H26FN5O4/c1-35-17-22-20(26(34)29-13-21-25(27)23(36-2)10-11-28-21)16-32(30-22)15-19-8-6-18(7-9-19)14-31-12-4-3-5-24(31)33/h3-12,16H,13-15,17H2,1-2H3,(H,29,34)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408746
PNG
( N-[(2,6-difluoro-3-methoxyphenyl)methyl]-3-(metho...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1c(F)ccc(OC)c1F
Show InChI InChI=1S/C27H26F2N4O4/c1-36-17-23-21(27(35)30-13-20-22(28)10-11-24(37-2)26(20)29)16-33(31-23)15-19-8-6-18(7-9-19)14-32-12-4-3-5-25(32)34/h3-12,16H,13-15,17H2,1-2H3,(H,30,35)
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n/an/a 4.60n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408798
PNG
( N-[(2,6-difluoro-3-methoxyphenyl)methyl]-1-({4-[(...)
Show SMILES COCc1nn(Cc2ccc(Cn3cc(F)ccc3=O)cc2)cc1C(=O)NCc1c(F)ccc(OC)c1F
Show InChI InChI=1S/C27H25F3N4O4/c1-37-16-23-21(27(36)31-11-20-22(29)8-9-24(38-2)26(20)30)15-34(32-23)13-18-5-3-17(4-6-18)12-33-14-19(28)7-10-25(33)35/h3-10,14-15H,11-13,16H2,1-2H3,(H,31,36)
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n/an/a 5.5n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408789
PNG
(N-[(6-chloro-2-fluoro-3-methoxyphenyl)methyl]-3-(m...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1c(Cl)ccc(O)c1F
Show InChI InChI=1S/C26H24ClFN4O4/c1-36-16-22-20(26(35)29-12-19-21(27)9-10-23(33)25(19)28)15-32(30-22)14-18-7-5-17(6-8-18)13-31-11-3-2-4-24(31)34/h2-11,15,33H,12-14,16H2,1H3,(H,29,35)
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n/an/a 6.40n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408775
PNG
( N-{[2-(difluoromethyl)-6-fluoro-3-methoxyphenyl]m...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1c(F)ccc(OC)c1C(F)F
Show InChI InChI=1S/C28H27F3N4O4/c1-38-17-23-21(28(37)32-13-20-22(29)10-11-24(39-2)26(20)27(30)31)16-35(33-23)15-19-8-6-18(7-9-19)14-34-12-4-3-5-25(34)36/h3-12,16,27H,13-15,17H2,1-2H3,(H,32,37)
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n/an/a 6.80n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408779
PNG
(N-[(2-carbamoyl-5-methoxyphenyl)methyl]-3-(methoxy...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cc(OC)ccc1C(N)=O
Show InChI InChI=1S/C28H29N5O5/c1-37-18-25-24(28(36)30-14-21-13-22(38-2)10-11-23(21)27(29)35)17-33(31-25)16-20-8-6-19(7-9-20)15-32-12-4-3-5-26(32)34/h3-13,17H,14-16,18H2,1-2H3,(H2,29,35)(H,30,36)
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n/an/a 8.70n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408666
PNG
(3-Amino-1-[4-(2-oxo-2H-pyridin-1-ylmethyl)-benzyl]...)
Show SMILES COc1cccc(CNC(=O)c2cn(Cc3ccc(Cn4ccccc4=O)cc3)nc2N)c1F
Show InChI InChI=1S/C25H24FN5O3/c1-34-21-6-4-5-19(23(21)26)13-28-25(33)20-16-31(29-24(20)27)15-18-10-8-17(9-11-18)14-30-12-3-2-7-22(30)32/h2-12,16H,13-15H2,1H3,(H2,27,29)(H,28,33)
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n/an/a 8.70n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408806
PNG
(3-amino-N-[(7-chloro-3,4-dihydro-2H-1,4-benzoxazin...)
Show SMILES Nc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCC1CNc2ccc(Cl)cc2O1
Show InChI InChI=1S/C26H25ClN6O3/c27-19-8-9-22-23(11-19)36-20(12-29-22)13-30-26(35)21-16-33(31-25(21)28)15-18-6-4-17(5-7-18)14-32-10-2-1-3-24(32)34/h1-11,16,20,29H,12-15H2,(H2,28,31)(H,30,35)
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n/an/a 10.6n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408770
PNG
( N-{[5-methoxy-2-(trifluoromethyl)phenyl]methyl}-3...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cc(OC)ccc1C(F)(F)F
Show InChI InChI=1S/C28H27F3N4O4/c1-38-18-25-23(27(37)32-14-21-13-22(39-2)10-11-24(21)28(29,30)31)17-35(33-25)16-20-8-6-19(7-9-20)15-34-12-4-3-5-26(34)36/h3-13,17H,14-16,18H2,1-2H3,(H,32,37)
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n/an/a 14.7n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408783
PNG
(N-{[2-(difluoromethoxy)-6-fluorophenyl]methyl}-3-(...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1c(F)cccc1OC(F)F
Show InChI InChI=1S/C27H25F3N4O4/c1-37-17-23-21(26(36)31-13-20-22(28)5-4-6-24(20)38-27(29)30)16-34(32-23)15-19-10-8-18(9-11-19)14-33-12-3-2-7-25(33)35/h2-12,16,27H,13-15,17H2,1H3,(H,31,36)
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n/an/a 16n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408750
PNG
(N-{[2-(difluoromethyl)-3-methoxyphenyl]methyl}-3-(...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cccc(OC)c1C(F)F
Show InChI InChI=1S/C28H28F2N4O4/c1-37-18-23-22(28(36)31-14-21-6-5-7-24(38-2)26(21)27(29)30)17-34(32-23)16-20-11-9-19(10-12-20)15-33-13-4-3-8-25(33)35/h3-13,17,27H,14-16,18H2,1-2H3,(H,31,36)
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n/an/a 16.8n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408734
PNG
( N-[(2-fluoro-3-methoxyphenyl)methyl]-3-(methoxyme...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cccc(OC)c1F
Show InChI InChI=1S/C27H27FN4O4/c1-35-18-23-22(27(34)29-14-21-6-5-7-24(36-2)26(21)28)17-32(30-23)16-20-11-9-19(10-12-20)15-31-13-4-3-8-25(31)33/h3-13,17H,14-16,18H2,1-2H3,(H,29,34)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408772
PNG
( N-{[2-(difluoromethyl)-6-fluorophenyl]methyl}-3-(...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1c(F)cccc1C(F)F
Show InChI InChI=1S/C27H25F3N4O3/c1-37-17-24-22(27(36)31-13-21-20(26(29)30)5-4-6-23(21)28)16-34(32-24)15-19-10-8-18(9-11-19)14-33-12-3-2-7-25(33)35/h2-12,16,26H,13-15,17H2,1H3,(H,31,36)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408733
PNG
( 3-cyclopropyl-N-[(2-fluoro-3-methoxyphenyl)methyl...)
Show SMILES COc1cccc(CNC(=O)c2cn(Cc3ccc(Cn4ccccc4=O)cc3)nc2C2CC2)c1F
Show InChI InChI=1S/C28H27FN4O3/c1-36-24-6-4-5-22(26(24)29)15-30-28(35)23-18-33(31-27(23)21-12-13-21)17-20-10-8-19(9-11-20)16-32-14-3-2-7-25(32)34/h2-11,14,18,21H,12-13,15-17H2,1H3,(H,30,35)
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n/an/a 23.3n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408753
PNG
( 3-amino-N-{[2-fluoro-6-(trifluoromethyl)phenyl]me...)
Show SMILES Nc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1c(F)cccc1C(F)(F)F
Show InChI InChI=1S/C25H21F4N5O2/c26-21-5-3-4-20(25(27,28)29)18(21)12-31-24(36)19-15-34(32-23(19)30)14-17-9-7-16(8-10-17)13-33-11-2-1-6-22(33)35/h1-11,15H,12-14H2,(H2,30,32)(H,31,36)
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n/an/a 26.7n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408759
PNG
(N-[(5-chloro-2-cyanophenyl)methyl]-3-(methoxymethy...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cc(Cl)ccc1C#N
Show InChI InChI=1S/C27H24ClN5O3/c1-36-18-25-24(27(35)30-14-22-12-23(28)10-9-21(22)13-29)17-33(31-25)16-20-7-5-19(6-8-20)15-32-11-3-2-4-26(32)34/h2-12,17H,14-16,18H2,1H3,(H,30,35)
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n/an/a 28.3n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408744
PNG
( N-[(2-fluoro-5-methoxyphenyl)methyl]-3-(methoxyme...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cc(OC)ccc1F
Show InChI InChI=1S/C27H27FN4O4/c1-35-18-25-23(27(34)29-14-21-13-22(36-2)10-11-24(21)28)17-32(30-25)16-20-8-6-19(7-9-20)15-31-12-4-3-5-26(31)33/h3-13,17H,14-16,18H2,1-2H3,(H,29,34)
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n/an/a 35.2n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408745
PNG
( N-[(2-fluoro-4-methylphenyl)methyl]-3-(methoxymet...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1ccc(C)cc1F
Show InChI InChI=1S/C27H27FN4O3/c1-19-6-11-22(24(28)13-19)14-29-27(34)23-17-32(30-25(23)18-35-2)16-21-9-7-20(8-10-21)15-31-12-4-3-5-26(31)33/h3-13,17H,14-16,18H2,1-2H3,(H,29,34)
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n/an/a 43.3n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408801
PNG
( N-[(2-fluoro-3-methoxyphenyl)methyl]-2-methyl-1-(...)
Show SMILES COc1cccc(CNC(=O)c2cn(Cc3ccc(Cn4ccccc4=O)cc3)c(C)n2)c1F
Show InChI InChI=1S/C26H25FN4O3/c1-18-29-22(26(33)28-14-21-6-5-7-23(34-2)25(21)27)17-31(18)16-20-11-9-19(10-12-20)15-30-13-4-3-8-24(30)32/h3-13,17H,14-16H2,1-2H3,(H,28,33)
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n/an/a 43.9n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408732
PNG
( N-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-1-...)
Show SMILES Fc1cccc(c1CNC(=O)c1cn(Cc2ccc(Cn3ccccc3=O)cc2)nc1C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C26H19F7N4O2/c27-21-5-3-4-20(25(28,29)30)18(21)12-34-24(39)19-15-37(35-23(19)26(31,32)33)14-17-9-7-16(8-10-17)13-36-11-2-1-6-22(36)38/h1-11,15H,12-14H2,(H,34,39)
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n/an/a 48.9n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408805
PNG
( 3-amino-N-[(7-chloro-4-methyl-2,3-dihydro-1,4-ben...)
Show SMILES CN1CC(CNC(=O)c2cn(Cc3ccc(Cn4ccccc4=O)cc3)nc2N)Oc2cc(Cl)ccc12
Show InChI InChI=1S/C27H27ClN6O3/c1-32-16-21(37-24-12-20(28)9-10-23(24)32)13-30-27(36)22-17-34(31-26(22)29)15-19-7-5-18(6-8-19)14-33-11-3-2-4-25(33)35/h2-12,17,21H,13-16H2,1H3,(H2,29,31)(H,30,36)
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n/an/a 64.7n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408738
PNG
( 3-(dimethylamino)-N-[(2-fluoro-3-methoxyphenyl)me...)
Show SMILES COc1cccc(CNC(=O)c2cn(Cc3ccc(Cn4ccccc4=O)cc3)nc2N(C)C)c1F
Show InChI InChI=1S/C27H28FN5O3/c1-31(2)26-22(27(35)29-15-21-7-6-8-23(36-3)25(21)28)18-33(30-26)17-20-12-10-19(11-13-20)16-32-14-5-4-9-24(32)34/h4-14,18H,15-17H2,1-3H3,(H,29,35)
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n/an/a 73.4n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408787
PNG
(N-[(2,5-difluoro-3-methoxyphenyl)methyl]-3-(methox...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cc(F)cc(OC)c1F
Show InChI InChI=1S/C27H26F2N4O4/c1-36-17-23-22(27(35)30-13-20-11-21(28)12-24(37-2)26(20)29)16-33(31-23)15-19-8-6-18(7-9-19)14-32-10-4-3-5-25(32)34/h3-12,16H,13-15,17H2,1-2H3,(H,30,35)
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n/an/a 75n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408778
PNG
( N-[(2-carbamoyl-6-fluorophenyl)methyl]-3-(methoxy...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1c(F)cccc1C(N)=O
Show InChI InChI=1S/C27H26FN5O4/c1-37-17-24-22(27(36)30-13-21-20(26(29)35)5-4-6-23(21)28)16-33(31-24)15-19-10-8-18(9-11-19)14-32-12-3-2-7-25(32)34/h2-12,16H,13-15,17H2,1H3,(H2,29,35)(H,30,36)
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n/an/a 79.2n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408749
PNG
( N-{[2-(difluoromethyl)phenyl]methyl}-3-(methoxyme...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1ccccc1C(F)F
Show InChI InChI=1S/C27H26F2N4O3/c1-36-18-24-23(27(35)30-14-21-6-2-3-7-22(21)26(28)29)17-33(31-24)16-20-11-9-19(10-12-20)15-32-13-5-4-8-25(32)34/h2-13,17,26H,14-16,18H2,1H3,(H,30,35)
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n/an/a 81.1n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408795
PNG
( 3-(methoxymethyl)-N-[(3-methoxyphenyl)methyl]-1-(...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cccc(OC)c1
Show InChI InChI=1S/C27H28N4O4/c1-34-19-25-24(27(33)28-15-22-6-5-7-23(14-22)35-2)18-31(29-25)17-21-11-9-20(10-12-21)16-30-13-4-3-8-26(30)32/h3-14,18H,15-17,19H2,1-2H3,(H,28,33)
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n/an/a 90.2n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408757
PNG
( N-[(3-chloro-2,6-difluorophenyl)methyl]-3-(methox...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1c(F)ccc(Cl)c1F
Show InChI InChI=1S/C26H23ClF2N4O3/c1-36-16-23-20(26(35)30-12-19-22(28)10-9-21(27)25(19)29)15-33(31-23)14-18-7-5-17(6-8-18)13-32-11-3-2-4-24(32)34/h2-11,15H,12-14,16H2,1H3,(H,30,35)
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n/an/a 120n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408794
PNG
( N-[(3-ethyl-2-fluorophenyl)methyl]-3-(methoxymeth...)
Show SMILES CCc1cccc(CNC(=O)c2cn(Cc3ccc(Cn4ccccc4=O)cc3)nc2COC)c1F
Show InChI InChI=1S/C28H29FN4O3/c1-3-22-7-6-8-23(27(22)29)15-30-28(35)24-18-33(31-25(24)19-36-2)17-21-12-10-20(11-13-21)16-32-14-5-4-9-26(32)34/h4-14,18H,3,15-17,19H2,1-2H3,(H,30,35)
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n/an/a 135n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408668
PNG
(N-[(2-fluoro-3-methoxyphenyl)methyl]-1-({4-[(4-met...)
Show SMILES COc1cccc(CNC(=O)c2cn(Cc3ccc(Cn4cc(C)cn4)cc3)nc2C(F)(F)F)c1F
Show InChI InChI=1S/C25H23F4N5O2/c1-16-10-31-33(12-16)13-17-6-8-18(9-7-17)14-34-15-20(23(32-34)25(27,28)29)24(35)30-11-19-4-3-5-21(36-2)22(19)26/h3-10,12,15H,11,13-14H2,1-2H3,(H,30,35)
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n/an/a 136n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408797
PNG
(N-[(2,6-difluoro-3-methoxyphenyl)methyl]-3-(methox...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccc(C)cc3=O)cc2)cc1C(=O)NCc1c(F)ccc(OC)c1F
Show InChI InChI=1S/C28H28F2N4O4/c1-18-10-11-33(26(35)12-18)14-19-4-6-20(7-5-19)15-34-16-22(24(32-34)17-37-2)28(36)31-13-21-23(29)8-9-25(38-3)27(21)30/h4-12,16H,13-15,17H2,1-3H3,(H,31,36)
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n/an/a 140n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408719
PNG
(N-[(5-chloro-1-benzothiophen-3-yl)methyl]-3-(metho...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1csc2ccc(Cl)cc12
Show InChI InChI=1S/C28H25ClN4O3S/c1-36-17-25-24(28(35)30-13-21-18-37-26-10-9-22(29)12-23(21)26)16-33(31-25)15-20-7-5-19(6-8-20)14-32-11-3-2-4-27(32)34/h2-12,16,18H,13-15,17H2,1H3,(H,30,35)
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n/an/a 144n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408788
PNG
( N-[(2-fluoro-6-methylphenyl)methyl]-3-(methoxymet...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1c(C)cccc1F
Show InChI InChI=1S/C27H27FN4O3/c1-19-6-5-7-24(28)22(19)14-29-27(34)23-17-32(30-25(23)18-35-2)16-21-11-9-20(10-12-21)15-31-13-4-3-8-26(31)33/h3-13,17H,14-16,18H2,1-2H3,(H,29,34)
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n/an/a 153n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408781
PNG
( N-{[3-(difluoromethoxy)-2-fluorophenyl]methyl}-3-...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cccc(OC(F)F)c1F
Show InChI InChI=1S/C27H25F3N4O4/c1-37-17-22-21(26(36)31-13-20-5-4-6-23(25(20)28)38-27(29)30)16-34(32-22)15-19-10-8-18(9-11-19)14-33-12-3-2-7-24(33)35/h2-12,16,27H,13-15,17H2,1H3,(H,31,36)
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n/an/a 154n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408792
PNG
( 3-amino-N-[(2-fluoro-3-hydroxyphenyl)methyl]-1-({...)
Show SMILES Nc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cccc(O)c1F
Show InChI InChI=1S/C24H22FN5O3/c25-22-18(4-3-5-20(22)31)12-27-24(33)19-15-30(28-23(19)26)14-17-9-7-16(8-10-17)13-29-11-2-1-6-21(29)32/h1-11,15,31H,12-14H2,(H2,26,28)(H,27,33)
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n/an/a 174n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408803
PNG
( N-[(2-fluoro-3-methoxyphenyl)methyl]-1-({4-[(2-ox...)
Show SMILES COc1cccc(CNC(=O)c2cn(Cc3ccc(Cn4ccccc4=O)cc3)c(n2)C(F)(F)F)c1F
Show InChI InChI=1S/C26H22F4N4O3/c1-37-21-6-4-5-19(23(21)27)13-31-24(36)20-16-34(25(32-20)26(28,29)30)15-18-10-8-17(9-11-18)14-33-12-3-2-7-22(33)35/h2-12,16H,13-15H2,1H3,(H,31,36)
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n/an/a 191n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408691
PNG
(N-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-1-(...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4c(F)cccc4C(F)(F)F)c(n3)C(F)(F)F)cc2)c1
Show InChI InChI=1S/C25H20F7N5O/c1-15-9-34-36(11-15)12-16-5-7-17(8-6-16)13-37-14-19(22(35-37)25(30,31)32)23(38)33-10-18-20(24(27,28)29)3-2-4-21(18)26/h2-9,11,14H,10,12-13H2,1H3,(H,33,38)
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n/an/a 219n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408678
PNG
(N-[(2-fluoro-5-methoxyphenyl)methyl]-1-({4-[(4-met...)
Show SMILES COc1ccc(F)c(CNC(=O)c2cn(Cc3ccc(Cn4cc(C)cn4)cc3)nc2C(F)(F)F)c1
Show InChI InChI=1S/C25H23F4N5O2/c1-16-10-31-33(12-16)13-17-3-5-18(6-4-17)14-34-15-21(23(32-34)25(27,28)29)24(35)30-11-19-9-20(36-2)7-8-22(19)26/h3-10,12,15H,11,13-14H2,1-2H3,(H,30,35)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408697
PNG
( N-{[3-chloro-2-fluoro-6-(trifluoromethyl)phenyl]m...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4c(F)c(Cl)ccc4C(F)(F)F)c(n3)C(F)(F)F)cc2)c1
Show InChI InChI=1S/C25H19ClF7N5O/c1-14-8-35-37(10-14)11-15-2-4-16(5-3-15)12-38-13-18(22(36-38)25(31,32)33)23(39)34-9-17-19(24(28,29)30)6-7-20(26)21(17)27/h2-8,10,13H,9,11-12H2,1H3,(H,34,39)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408692
PNG
(N-[(4-chloro-2,6-difluorophenyl)methyl]-1-({4-[(4-...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4c(F)cc(Cl)cc4F)c(n3)C(F)(F)F)cc2)c1
Show InChI InChI=1S/C24H19ClF5N5O/c1-14-8-32-34(10-14)11-15-2-4-16(5-3-15)12-35-13-19(22(33-35)24(28,29)30)23(36)31-9-18-20(26)6-17(25)7-21(18)27/h2-8,10,13H,9,11-12H2,1H3,(H,31,36)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408708
PNG
(N-[(2-fluoro-4-methylphenyl)methyl]-1-({4-[(4-meth...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4ccc(C)cc4F)c(n3)C(F)(F)F)cc2)c1
Show InChI InChI=1S/C25H23F4N5O/c1-16-3-8-20(22(26)9-16)11-30-24(35)21-15-34(32-23(21)25(27,28)29)14-19-6-4-18(5-7-19)13-33-12-17(2)10-31-33/h3-10,12,15H,11,13-14H2,1-2H3,(H,30,35)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408755
PNG
( 3-acetamido-N-[(2-fluoro-3-methoxyphenyl)methyl]-...)
Show SMILES COc1cccc(CNC(=O)c2cn(Cc3ccc(Cn4ccccc4=O)cc3)nc2NC(C)=O)c1F
Show InChI InChI=1S/C27H26FN5O4/c1-18(34)30-26-22(27(36)29-14-21-6-5-7-23(37-2)25(21)28)17-33(31-26)16-20-11-9-19(10-12-20)15-32-13-4-3-8-24(32)35/h3-13,17H,14-16H2,1-2H3,(H,29,36)(H,30,31,34)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408786
PNG
(N-[(3-fluoro-5-methoxyphenyl)methyl]-3-(methoxymet...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cc(F)cc(OC)c1
Show InChI InChI=1S/C27H27FN4O4/c1-35-18-25-24(27(34)29-14-21-11-22(28)13-23(12-21)36-2)17-32(30-25)16-20-8-6-19(7-9-20)15-31-10-4-3-5-26(31)33/h3-13,17H,14-16,18H2,1-2H3,(H,29,34)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408742
PNG
( 3-(methoxymethyl)-1-({4-[(2-oxopyridin-1-yl)methy...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1ccccc1C(F)(F)F
Show InChI InChI=1S/C27H25F3N4O3/c1-37-18-24-22(26(36)31-14-21-6-2-3-7-23(21)27(28,29)30)17-34(32-24)16-20-11-9-19(10-12-20)15-33-13-5-4-8-25(33)35/h2-13,17H,14-16,18H2,1H3,(H,31,36)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408671
PNG
(N-[(3-methoxyphenyl)methyl]-1-({4-[(4-methylpyrazo...)
Show SMILES COc1cccc(CNC(=O)c2cn(Cc3ccc(Cn4cc(C)cn4)cc3)nc2C(F)(F)F)c1
Show InChI InChI=1S/C25H24F3N5O2/c1-17-11-30-32(13-17)14-18-6-8-19(9-7-18)15-33-16-22(23(31-33)25(26,27)28)24(34)29-12-20-4-3-5-21(10-20)35-2/h3-11,13,16H,12,14-15H2,1-2H3,(H,29,34)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408694
PNG
(N-[(3-chloro-2,6-difluorophenyl)methyl]-1-({4-[(4-...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4c(F)ccc(Cl)c4F)c(n3)C(F)(F)F)cc2)c1
Show InChI InChI=1S/C24H19ClF5N5O/c1-14-8-32-34(10-14)11-15-2-4-16(5-3-15)12-35-13-18(22(33-35)24(28,29)30)23(36)31-9-17-20(26)7-6-19(25)21(17)27/h2-8,10,13H,9,11-12H2,1H3,(H,31,36)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408711
PNG
(3-(methoxymethyl)-1-({4-[(2-oxopyridin-1-yl)methyl...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cnccc1C(F)(F)F
Show InChI InChI=1S/C26H24F3N5O3/c1-37-17-23-21(25(36)31-13-20-12-30-10-9-22(20)26(27,28)29)16-34(32-23)15-19-7-5-18(6-8-19)14-33-11-3-2-4-24(33)35/h2-12,16H,13-15,17H2,1H3,(H,31,36)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408711
PNG
(3-(methoxymethyl)-1-({4-[(2-oxopyridin-1-yl)methyl...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cnccc1C(F)(F)F
Show InChI InChI=1S/C26H24F3N5O3/c1-37-17-23-21(25(36)31-13-20-12-30-10-9-22(20)26(27,28)29)16-34(32-23)15-19-7-5-18(6-8-19)14-33-11-3-2-4-24(33)35/h2-12,16H,13-15,17H2,1H3,(H,31,36)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408747
PNG
( N-[(3-chloro-5-methoxyphenyl)methyl]-3-(methoxyme...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cc(Cl)cc(OC)c1
Show InChI InChI=1S/C27H27ClN4O4/c1-35-18-25-24(27(34)29-14-21-11-22(28)13-23(12-21)36-2)17-32(30-25)16-20-8-6-19(7-9-20)15-31-10-4-3-5-26(31)33/h3-13,17H,14-16,18H2,1-2H3,(H,29,34)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408790
PNG
(N-[(2-fluoro-3-hydroxyphenyl)methyl]-3-(methoxymet...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cccc(O)c1F
Show InChI InChI=1S/C26H25FN4O4/c1-35-17-22-21(26(34)28-13-20-5-4-6-23(32)25(20)27)16-31(29-22)15-19-10-8-18(9-11-19)14-30-12-3-2-7-24(30)33/h2-12,16,32H,13-15,17H2,1H3,(H,28,34)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408686
PNG
(N-[(2,6-difluorophenyl)methyl]-1-({4-[(4-methylpyr...)
Show SMILES Cc1cn(Cc2c(F)cccc2F)nc1Cc1ccc(CNC(=O)c2c[nH]nc2C(F)(F)F)cc1
Show InChI InChI=1S/C24H20F5N5O/c1-14-12-34(13-18-19(25)3-2-4-20(18)26)33-21(14)9-15-5-7-16(8-6-15)10-30-23(35)17-11-31-32-22(17)24(27,28)29/h2-8,11-12H,9-10,13H2,1H3,(H,30,35)(H,31,32)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408683
PNG
( N-[(2,6-difluoro-4-methoxyphenyl)methyl]-1-({4-[(...)
Show SMILES COc1cc(F)c(CNC(=O)c2cn(Cc3ccc(Cn4cc(C)cn4)cc3)nc2C(F)(F)F)c(F)c1
Show InChI InChI=1S/C25H22F5N5O2/c1-15-9-32-34(11-15)12-16-3-5-17(6-4-16)13-35-14-20(23(33-35)25(28,29)30)24(36)31-10-19-21(26)7-18(37-2)8-22(19)27/h3-9,11,14H,10,12-13H2,1-2H3,(H,31,36)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408689
PNG
(N-[(2-chloro-6-fluorophenyl)methyl]-1-({4-[(4-meth...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4c(F)cccc4Cl)c(n3)C(F)(F)F)cc2)c1
Show InChI InChI=1S/C24H20ClF4N5O/c1-15-9-31-33(11-15)12-16-5-7-17(8-6-16)13-34-14-19(22(32-34)24(27,28)29)23(35)30-10-18-20(25)3-2-4-21(18)26/h2-9,11,14H,10,12-13H2,1H3,(H,30,35)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408782
PNG
( N-{[3-(difluoromethoxy)phenyl]methyl}-3-(methoxym...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cccc(OC(F)F)c1
Show InChI InChI=1S/C27H26F2N4O4/c1-36-18-24-23(26(35)30-14-21-5-4-6-22(13-21)37-27(28)29)17-33(31-24)16-20-10-8-19(9-11-20)15-32-12-3-2-7-25(32)34/h2-13,17,27H,14-16,18H2,1H3,(H,30,35)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408676
PNG
(N-[(4-methylphenyl)methyl]-1-({4-[(4-methylpyrazol...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4ccc(C)cc4)c(n3)C(F)F)cc2)c1
Show InChI InChI=1S/C25H25F2N5O/c1-17-3-5-19(6-4-17)12-28-25(33)22-16-32(30-23(22)24(26)27)15-21-9-7-20(8-10-21)14-31-13-18(2)11-29-31/h3-11,13,16,24H,12,14-15H2,1-2H3,(H,28,33)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408740
PNG
(N-[(2-fluorophenyl)methyl]-3-(methoxymethyl)-1-({4...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1ccccc1F
Show InChI InChI=1S/C26H25FN4O3/c1-34-18-24-22(26(33)28-14-21-6-2-3-7-23(21)27)17-31(29-24)16-20-11-9-19(10-12-20)15-30-13-5-4-8-25(30)32/h2-13,17H,14-16,18H2,1H3,(H,28,33)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408769
PNG
( N-{[3-methoxy-2-(trifluoromethyl)phenyl]methyl}-3...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cccc(OC)c1C(F)(F)F
Show InChI InChI=1S/C28H27F3N4O4/c1-38-18-23-22(27(37)32-14-21-6-5-7-24(39-2)26(21)28(29,30)31)17-35(33-23)16-20-11-9-19(10-12-20)15-34-13-4-3-8-25(34)36/h3-13,17H,14-16,18H2,1-2H3,(H,32,37)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408726
PNG
(N-[(2-carbamoylphenyl)methyl]-3-cyclopropyl-1-({4-...)
Show SMILES NC(=O)c1ccccc1CNC(=O)c1cn(Cc2ccc(Cn3ccccc3=O)cc2)nc1C1CC1
Show InChI InChI=1S/C28H27N5O3/c29-27(35)23-6-2-1-5-22(23)15-30-28(36)24-18-33(31-26(24)21-12-13-21)17-20-10-8-19(9-11-20)16-32-14-4-3-7-25(32)34/h1-11,14,18,21H,12-13,15-17H2,(H2,29,35)(H,30,36)
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n/an/a 647n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408796
PNG
( N-[(2-fluoro-3-methoxyphenyl)methyl]-3-(methoxyme...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccncc3=O)cc2)cc1C(=O)NCc1cccc(OC)c1F
Show InChI InChI=1S/C26H26FN5O4/c1-35-17-22-21(26(34)29-12-20-4-3-5-23(36-2)25(20)27)16-32(30-22)15-19-8-6-18(7-9-19)14-31-11-10-28-13-24(31)33/h3-11,13,16H,12,14-15,17H2,1-2H3,(H,29,34)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408665
PNG
(N-(3,5-Dimethoxybenzyl)-3-(methoxymethyl)-1-(4-((2...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cc(OC)cc(OC)c1
Show InChI InChI=1S/C28H30N4O5/c1-35-19-26-25(28(34)29-15-22-12-23(36-2)14-24(13-22)37-3)18-32(30-26)17-21-9-7-20(8-10-21)16-31-11-5-4-6-27(31)33/h4-14,18H,15-17,19H2,1-3H3,(H,29,34)
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n/an/a 698n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408700
PNG
( N-[(2,4-dimethylphenyl)methyl]-1-({4-[(4-methylpy...)
Show SMILES Cc1cn(Cc2ccc(C)cc2C)nc1Cc1ccc(CNC(=O)c2c[nH]nc2C(F)(F)F)cc1
Show InChI InChI=1S/C26H26F3N5O/c1-16-4-9-21(17(2)10-16)15-34-14-18(3)23(33-34)11-19-5-7-20(8-6-19)12-30-25(35)22-13-31-32-24(22)26(27,28)29/h4-10,13-14H,11-12,15H2,1-3H3,(H,30,35)(H,31,32)
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n/an/a 717n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408696
PNG
(N-[(5-chloro-2-fluorophenyl)methyl]-1-({4-[(4-meth...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4cc(Cl)ccc4F)c(n3)C(F)(F)F)cc2)c1
Show InChI InChI=1S/C24H20ClF4N5O/c1-15-9-31-33(11-15)12-16-2-4-17(5-3-16)13-34-14-20(22(32-34)24(27,28)29)23(35)30-10-18-8-19(25)6-7-21(18)26/h2-9,11,14H,10,12-13H2,1H3,(H,30,35)
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n/an/a 740n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408804
PNG
(N-[(2-fluoro-3-methoxyphenyl)methyl]-1-{[6-(pyrrol...)
Show SMILES COc1cccc(CNC(=O)c2cn(Cc3ccc(nc3)N3CCCC3)nc2C(F)(F)F)c1F
Show InChI InChI=1S/C23H23F4N5O2/c1-34-18-6-4-5-16(20(18)24)12-29-22(33)17-14-32(30-21(17)23(25,26)27)13-15-7-8-19(28-11-15)31-9-2-3-10-31/h4-8,11,14H,2-3,9-10,12-13H2,1H3,(H,29,33)
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n/an/a 742n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408685
PNG
(N-{[4-methoxy-2-(trifluoromethyl)phenyl]methyl}-1-...)
Show SMILES COc1ccc(CNC(=O)c2cn(Cc3ccc(Cn4cc(C)cn4)cc3)nc2C(F)(F)F)c(c1)C(F)(F)F
Show InChI InChI=1S/C26H23F6N5O2/c1-16-10-34-36(12-16)13-17-3-5-18(6-4-17)14-37-15-21(23(35-37)26(30,31)32)24(38)33-11-19-7-8-20(39-2)9-22(19)25(27,28)29/h3-10,12,15H,11,13-14H2,1-2H3,(H,33,38)
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n/an/a 746n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408725
PNG
( N-[(5-chloro-1-benzothiophen-3-yl)methyl]-3-(meth...)
Show SMILES COCc1nn(Cc2ccc(Cn3cc(C)cn3)cc2)cc1C(=O)NCc1csc2ccc(Cl)cc12
Show InChI InChI=1S/C27H26ClN5O2S/c1-18-10-30-32(12-18)13-19-3-5-20(6-4-19)14-33-15-24(25(31-33)16-35-2)27(34)29-11-21-17-36-26-8-7-22(28)9-23(21)26/h3-10,12,15,17H,11,13-14,16H2,1-2H3,(H,29,34)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408784
PNG
( N-[(2,5-difluorophenyl)methyl]-3-(methoxymethyl)-...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cc(F)ccc1F
Show InChI InChI=1S/C26H24F2N4O3/c1-35-17-24-22(26(34)29-13-20-12-21(27)9-10-23(20)28)16-32(30-24)15-19-7-5-18(6-8-19)14-31-11-3-2-4-25(31)33/h2-12,16H,13-15,17H2,1H3,(H,29,34)
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n/an/a 780n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408718
PNG
(N-[(3-fluoro-6-methoxypyridin-2-yl)methyl]-3-(meth...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1nc(OC)ccc1F
Show InChI InChI=1S/C26H26FN5O4/c1-35-17-23-20(26(34)28-13-22-21(27)10-11-24(29-22)36-2)16-32(30-23)15-19-8-6-18(7-9-19)14-31-12-4-3-5-25(31)33/h3-12,16H,13-15,17H2,1-2H3,(H,28,34)
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n/an/a 831n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408693
PNG
( N-[(4-chloro-2-fluorophenyl)methyl]-1-({4-[(4-met...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4ccc(Cl)cc4F)c(n3)C(F)(F)F)cc2)c1
Show InChI InChI=1S/C24H20ClF4N5O/c1-15-9-31-33(11-15)12-16-2-4-17(5-3-16)13-34-14-20(22(32-34)24(27,28)29)23(35)30-10-18-6-7-19(25)8-21(18)26/h2-9,11,14H,10,12-13H2,1H3,(H,30,35)
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n/an/a 865n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408710
PNG
(-[(4-chloropyridin-2-yl)methyl]-1-({4-[(4-methylpy...)
Show SMILES Cc1cn(Cc2cc(Cl)ccn2)nc1Cc1ccc(CNC(=O)c2c[nH]nc2C(F)(F)F)cc1
Show InChI InChI=1S/C23H20ClF3N6O/c1-14-12-33(13-18-9-17(24)6-7-28-18)32-20(14)8-15-2-4-16(5-3-15)10-29-22(34)19-11-30-31-21(19)23(25,26)27/h2-7,9,11-12H,8,10,13H2,1H3,(H,29,34)(H,30,31)
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n/an/a 915n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408699
PNG
( N-{[5-chloro-2-(trifluoromethyl)phenyl]methyl}-1-...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4cc(Cl)ccc4C(F)(F)F)c(n3)C(F)(F)F)cc2)c1
Show InChI InChI=1S/C25H20ClF6N5O/c1-15-9-34-36(11-15)12-16-2-4-17(5-3-16)13-37-14-20(22(35-37)25(30,31)32)23(38)33-10-18-8-19(26)6-7-21(18)24(27,28)29/h2-9,11,14H,10,12-13H2,1H3,(H,33,38)
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n/an/a 1.06E+3n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408695
PNG
(N-[(3-chloro-2-fluorophenyl)methyl]-1-({4-[(4-meth...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4cccc(Cl)c4F)c(n3)C(F)(F)F)cc2)c1
Show InChI InChI=1S/C24H20ClF4N5O/c1-15-9-31-33(11-15)12-16-5-7-17(8-6-16)13-34-14-19(22(32-34)24(27,28)29)23(35)30-10-18-3-2-4-20(25)21(18)26/h2-9,11,14H,10,12-13H2,1H3,(H,30,35)
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n/an/a 1.13E+3n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408681
PNG
(N-[(2,4-dimethoxyphenyl)methyl]-1-({4-[(4-methylpy...)
Show SMILES COc1ccc(CNC(=O)c2cn(Cc3ccc(Cn4cc(C)cn4)cc3)nc2C(F)(F)F)c(OC)c1
Show InChI InChI=1S/C26H26F3N5O3/c1-17-11-31-33(13-17)14-18-4-6-19(7-5-18)15-34-16-22(24(32-34)26(27,28)29)25(35)30-12-20-8-9-21(36-2)10-23(20)37-3/h4-11,13,16H,12,14-15H2,1-3H3,(H,30,35)
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n/an/a 1.27E+3n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408705
PNG
( 1-({4-[(4-methylpyrazol-1-yl)methyl]phenyl}methyl...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4c(C)cc(C)cc4C)c(n3)C(F)(F)F)cc2)c1
Show InChI InChI=1S/C27H28F3N5O/c1-17-9-19(3)23(20(4)10-17)12-31-26(36)24-16-35(33-25(24)27(28,29)30)15-22-7-5-21(6-8-22)14-34-13-18(2)11-32-34/h5-11,13,16H,12,14-15H2,1-4H3,(H,31,36)
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n/an/a 1.34E+3n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408698
PNG
(N-[(2,6-dichlorophenyl)methyl]-1-({4-[(4-methylpyr...)
Show SMILES Cc1cn(Cc2c(Cl)cccc2Cl)nc1Cc1ccc(CNC(=O)c2c[nH]nc2C(F)(F)F)cc1
Show InChI InChI=1S/C24H20Cl2F3N5O/c1-14-12-34(13-18-19(25)3-2-4-20(18)26)33-21(14)9-15-5-7-16(8-6-15)10-30-23(35)17-11-31-32-22(17)24(27,28)29/h2-8,11-12H,9-10,13H2,1H3,(H,30,35)(H,31,32)
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n/an/a 1.35E+3n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408793
PNG
( methyl 2-({[3-(methoxymethyl)-1-({4-[(2-oxopyridi...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1ccccc1C(=O)OC
Show InChI InChI=1S/C28H28N4O5/c1-36-19-25-24(27(34)29-15-22-7-3-4-8-23(22)28(35)37-2)18-32(30-25)17-21-12-10-20(11-13-21)16-31-14-6-5-9-26(31)33/h3-14,18H,15-17,19H2,1-2H3,(H,29,34)
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n/an/a 1.51E+3n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408730
PNG
(N-[(4-carbamoylphenyl)methyl]-3-cyclopropyl-1-({4-...)
Show SMILES NC(=O)c1ccc(CNC(=O)c2cn(Cc3ccc(Cn4ccccc4=O)cc3)nc2C2CC2)cc1
Show InChI InChI=1S/C28H27N5O3/c29-27(35)23-10-8-19(9-11-23)15-30-28(36)24-18-33(31-26(24)22-12-13-22)17-21-6-4-20(5-7-21)16-32-14-2-1-3-25(32)34/h1-11,14,18,22H,12-13,15-17H2,(H2,29,35)(H,30,36)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408704
PNG
(N-[(2,6-dimethylphenyl)methyl]-1-({4-[(4-methylpyr...)
Show SMILES Cc1cn(Cc2c(C)cccc2C)nc1Cc1ccc(CNC(=O)c2c[nH]nc2C(F)(F)F)cc1
Show InChI InChI=1S/C26H26F3N5O/c1-16-5-4-6-17(2)22(16)15-34-14-18(3)23(33-34)11-19-7-9-20(10-8-19)12-30-25(35)21-13-31-32-24(21)26(27,28)29/h4-10,13-14H,11-12,15H2,1-3H3,(H,30,35)(H,31,32)
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n/an/a 1.84E+3n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408709
PNG
(N-[(3-fluoropyridin-2-yl)methyl]-1-({4-[(4-methylp...)
Show SMILES Cc1cn(Cc2ncccc2F)nc1Cc1ccc(CNC(=O)c2c[nH]nc2C(F)(F)F)cc1
Show InChI InChI=1S/C23H20F4N6O/c1-14-12-33(13-20-18(24)3-2-8-28-20)32-19(14)9-15-4-6-16(7-5-15)10-29-22(34)17-11-30-31-21(17)23(25,26)27/h2-8,11-12H,9-10,13H2,1H3,(H,29,34)(H,30,31)
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n/an/a 2.19E+3n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408672
PNG
(N-[(3-ethoxyphenyl)methyl]-1-({4-[(4-methylpyrazol...)
Show SMILES CCOc1cccc(CNC(=O)c2cn(Cc3ccc(Cn4cc(C)cn4)cc3)nc2C(F)(F)F)c1
Show InChI InChI=1S/C26H26F3N5O2/c1-3-36-22-6-4-5-21(11-22)13-30-25(35)23-17-34(32-24(23)26(27,28)29)16-20-9-7-19(8-10-20)15-33-14-18(2)12-31-33/h4-12,14,17H,3,13,15-16H2,1-2H3,(H,30,35)
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n/an/a 2.36E+3n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408720
PNG
(N-[(5-chloro-1-benzothiophen-3-yl)methyl]-3-(metho...)
Show SMILES COCc1nn(Cc2ccc(nc2)N2CCCC2)cc1C(=O)NCc1csc2ccc(Cl)cc12
Show InChI InChI=1S/C25H26ClN5O2S/c1-33-15-22-21(25(32)28-12-18-16-34-23-6-5-19(26)10-20(18)23)14-31(29-22)13-17-4-7-24(27-11-17)30-8-2-3-9-30/h4-7,10-11,14,16H,2-3,8-9,12-13,15H2,1H3,(H,28,32)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408667
PNG
(1-(7-Chloro-quinolin-3-ylmethyl)-3-methoxymethyl-1...)
Show SMILES COCc1nn(Cc2cnc3cc(Cl)ccc3c2)cc1C(=O)NCc1cccc(OC)c1F
Show InChI InChI=1S/C24H22ClFN4O3/c1-32-14-21-19(24(31)28-11-17-4-3-5-22(33-2)23(17)26)13-30(29-21)12-15-8-16-6-7-18(25)9-20(16)27-10-15/h3-10,13H,11-12,14H2,1-2H3,(H,28,31)
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n/an/a 2.58E+3n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408799
PNG
(N-[(2,6-difluoro-3-methoxyphenyl)methyl]-1-({4-[(4...)
Show SMILES CCOc1ccn(Cc2ccc(Cn3cc(C(=O)NCc4c(F)ccc(OC)c4F)c(COC)n3)cc2)c(=O)c1
Show InChI InChI=1S/C29H30F2N4O5/c1-4-40-21-11-12-34(27(36)13-21)15-19-5-7-20(8-6-19)16-35-17-23(25(33-35)18-38-2)29(37)32-14-22-24(30)9-10-26(39-3)28(22)31/h5-13,17H,4,14-16,18H2,1-3H3,(H,32,37)
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n/an/a 2.98E+3n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408716
PNG
(3-(methoxymethyl)-N-[(6-methoxypyridin-2-yl)methyl...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cccc(OC)n1
Show InChI InChI=1S/C26H27N5O4/c1-34-18-23-22(26(33)27-14-21-6-5-7-24(28-21)35-2)17-31(29-23)16-20-11-9-19(10-12-20)15-30-13-4-3-8-25(30)32/h3-13,17H,14-16,18H2,1-2H3,(H,27,33)
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n/an/a 3.70E+3n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408713
PNG
( 3-(methoxymethyl)-1-({4-[(2-oxopyridin-1-yl)methy...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cccnc1C(F)(F)F
Show InChI InChI=1S/C26H24F3N5O3/c1-37-17-22-21(25(36)31-13-20-5-4-11-30-24(20)26(27,28)29)16-34(32-22)15-19-9-7-18(8-10-19)14-33-12-3-2-6-23(33)35/h2-12,16H,13-15,17H2,1H3,(H,31,36)
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n/an/a 4.17E+3n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408727
PNG
( N-[(3-carbamoylphenyl)methyl]-3-cyclopropyl-1-({4...)
Show SMILES NC(=O)c1cccc(CNC(=O)c2cn(Cc3ccc(Cn4ccccc4=O)cc3)nc2C2CC2)c1
Show InChI InChI=1S/C28H27N5O3/c29-27(35)23-5-3-4-21(14-23)15-30-28(36)24-18-33(31-26(24)22-11-12-22)17-20-9-7-19(8-10-20)16-32-13-2-1-6-25(32)34/h1-10,13-14,18,22H,11-12,15-17H2,(H2,29,35)(H,30,36)
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n/an/a 5.45E+3n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408737
PNG
(3-amino-1-({4-[(2-oxopyridin-1-yl)methyl]phenyl}me...)
Show SMILES Nc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C25H22F3N5O3/c26-25(27,28)36-20-10-8-17(9-11-20)13-30-24(35)21-16-33(31-23(21)29)15-19-6-4-18(5-7-19)14-32-12-2-1-3-22(32)34/h1-12,16H,13-15H2,(H2,29,31)(H,30,35)
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n/an/a 5.78E+3n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408756
PNG
(N-[(2-fluoro-3-methoxyphenyl)methyl]-3-(N-methylac...)
Show SMILES COc1cccc(CNC(=O)c2cn(Cc3ccc(Cn4ccccc4=O)cc3)nc2N(C)C(C)=O)c1F
Show InChI InChI=1S/C28H28FN5O4/c1-19(35)32(2)27-23(28(37)30-15-22-7-6-8-24(38-3)26(22)29)18-34(31-27)17-21-12-10-20(11-13-21)16-33-14-5-4-9-25(33)36/h4-14,18H,15-17H2,1-3H3,(H,30,37)
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n/an/a 6.61E+3n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408712
PNG
(3-(methoxymethyl)-N-[(6-methylpyridin-3-yl)methyl]...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1ccc(C)nc1
Show InChI InChI=1S/C26H27N5O3/c1-19-6-7-22(13-27-19)14-28-26(33)23-17-31(29-24(23)18-34-2)16-21-10-8-20(9-11-21)15-30-12-4-3-5-25(30)32/h3-13,17H,14-16,18H2,1-2H3,(H,28,33)
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n/an/a 7.87E+3n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408712
PNG
(3-(methoxymethyl)-N-[(6-methylpyridin-3-yl)methyl]...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1ccc(C)nc1
Show InChI InChI=1S/C26H27N5O3/c1-19-6-7-22(13-27-19)14-28-26(33)23-17-31(29-24(23)18-34-2)16-21-10-8-20(9-11-21)15-30-12-4-3-5-25(30)32/h3-13,17H,14-16,18H2,1-2H3,(H,28,33)
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n/an/a 7.87E+3n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408749
PNG
( N-{[2-(difluoromethyl)phenyl]methyl}-3-(methoxyme...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1ccccc1C(F)F
Show InChI InChI=1S/C27H26F2N4O3/c1-36-18-24-23(27(35)30-14-21-6-2-3-7-22(21)26(28)29)17-33(31-24)16-20-11-9-19(10-12-20)15-32-13-5-4-8-25(32)34/h2-13,17,26H,14-16,18H2,1H3,(H,30,35)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408753
PNG
( 3-amino-N-{[2-fluoro-6-(trifluoromethyl)phenyl]me...)
Show SMILES Nc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1c(F)cccc1C(F)(F)F
Show InChI InChI=1S/C25H21F4N5O2/c26-21-5-3-4-20(25(27,28)29)18(21)12-31-24(36)19-15-34(32-23(19)30)14-17-9-7-16(8-10-17)13-33-11-2-1-6-22(33)35/h1-11,15H,12-14H2,(H2,30,32)(H,31,36)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408780
PNG
( 2-({[3-(methoxymethyl)-1-({4-[(2-oxopyridin-1-yl)...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1ccccc1C(O)=O
Show InChI InChI=1S/C27H26N4O5/c1-36-18-24-23(26(33)28-14-21-6-2-3-7-22(21)27(34)35)17-31(29-24)16-20-11-9-19(10-12-20)15-30-13-5-4-8-25(30)32/h2-13,17H,14-16,18H2,1H3,(H,28,33)(H,34,35)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408665
PNG
(N-(3,5-Dimethoxybenzyl)-3-(methoxymethyl)-1-(4-((2...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cc(OC)cc(OC)c1
Show InChI InChI=1S/C28H30N4O5/c1-35-19-26-25(28(34)29-15-22-12-23(36-2)14-24(13-22)37-3)18-32(30-26)17-21-9-7-20(8-10-21)16-31-11-5-4-6-27(31)33/h4-14,18H,15-17,19H2,1-3H3,(H,29,34)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408672
PNG
(N-[(3-ethoxyphenyl)methyl]-1-({4-[(4-methylpyrazol...)
Show SMILES CCOc1cccc(CNC(=O)c2cn(Cc3ccc(Cn4cc(C)cn4)cc3)nc2C(F)(F)F)c1
Show InChI InChI=1S/C26H26F3N5O2/c1-3-36-22-6-4-5-21(11-22)13-30-25(35)23-17-34(32-24(23)26(27,28)29)16-20-9-7-19(8-10-20)15-33-14-18(2)12-31-33/h4-12,14,17H,3,13,15-16H2,1-2H3,(H,30,35)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408689
PNG
(N-[(2-chloro-6-fluorophenyl)methyl]-1-({4-[(4-meth...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4c(F)cccc4Cl)c(n3)C(F)(F)F)cc2)c1
Show InChI InChI=1S/C24H20ClF4N5O/c1-15-9-31-33(11-15)12-16-5-7-17(8-6-16)13-34-14-19(22(32-34)24(27,28)29)23(35)30-10-18-20(25)3-2-4-21(18)26/h2-9,11,14H,10,12-13H2,1H3,(H,30,35)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408699
PNG
( N-{[5-chloro-2-(trifluoromethyl)phenyl]methyl}-1-...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4cc(Cl)ccc4C(F)(F)F)c(n3)C(F)(F)F)cc2)c1
Show InChI InChI=1S/C25H20ClF6N5O/c1-15-9-34-36(11-15)12-16-2-4-17(5-3-16)13-37-14-20(22(35-37)25(30,31)32)23(38)33-10-18-8-19(26)6-7-21(18)24(27,28)29/h2-9,11,14H,10,12-13H2,1H3,(H,33,38)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408711
PNG
(3-(methoxymethyl)-1-({4-[(2-oxopyridin-1-yl)methyl...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cnccc1C(F)(F)F
Show InChI InChI=1S/C26H24F3N5O3/c1-37-17-23-21(25(36)31-13-20-12-30-10-9-22(20)26(27,28)29)16-34(32-23)15-19-7-5-18(6-8-19)14-33-11-3-2-4-24(33)35/h2-12,16H,13-15,17H2,1H3,(H,31,36)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408727
PNG
( N-[(3-carbamoylphenyl)methyl]-3-cyclopropyl-1-({4...)
Show SMILES NC(=O)c1cccc(CNC(=O)c2cn(Cc3ccc(Cn4ccccc4=O)cc3)nc2C2CC2)c1
Show InChI InChI=1S/C28H27N5O3/c29-27(35)23-5-3-4-21(14-23)15-30-28(36)24-18-33(31-26(24)22-11-12-22)17-20-9-7-19(8-10-20)16-32-13-2-1-6-25(32)34/h1-10,13-14,18,22H,11-12,15-17H2,(H2,29,35)(H,30,36)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408788
PNG
( N-[(2-fluoro-6-methylphenyl)methyl]-3-(methoxymet...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1c(C)cccc1F
Show InChI InChI=1S/C27H27FN4O3/c1-19-6-5-7-24(28)22(19)14-29-27(34)23-17-32(30-25(23)18-35-2)16-21-11-9-20(10-12-21)15-31-13-4-3-8-26(31)33/h3-13,17H,14-16,18H2,1-2H3,(H,29,34)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408801
PNG
( N-[(2-fluoro-3-methoxyphenyl)methyl]-2-methyl-1-(...)
Show SMILES COc1cccc(CNC(=O)c2cn(Cc3ccc(Cn4ccccc4=O)cc3)c(C)n2)c1F
Show InChI InChI=1S/C26H25FN4O3/c1-18-29-22(26(33)28-14-21-6-5-7-23(34-2)25(21)27)17-31(18)16-20-11-9-19(10-12-20)15-30-13-4-3-8-24(30)32/h3-13,17H,14-16H2,1-2H3,(H,28,33)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408803
PNG
( N-[(2-fluoro-3-methoxyphenyl)methyl]-1-({4-[(2-ox...)
Show SMILES COc1cccc(CNC(=O)c2cn(Cc3ccc(Cn4ccccc4=O)cc3)c(n2)C(F)(F)F)c1F
Show InChI InChI=1S/C26H22F4N4O3/c1-37-21-6-4-5-19(23(21)27)13-31-24(36)20-16-34(25(32-20)26(28,29)30)15-18-10-8-17(9-11-18)14-33-12-3-2-7-22(33)35/h2-12,16H,13-15H2,1H3,(H,31,36)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408683
PNG
( N-[(2,6-difluoro-4-methoxyphenyl)methyl]-1-({4-[(...)
Show SMILES COc1cc(F)c(CNC(=O)c2cn(Cc3ccc(Cn4cc(C)cn4)cc3)nc2C(F)(F)F)c(F)c1
Show InChI InChI=1S/C25H22F5N5O2/c1-15-9-32-34(11-15)12-16-3-5-17(6-4-16)13-35-14-20(23(33-35)25(28,29)30)24(36)31-10-19-21(26)7-18(37-2)8-22(19)27/h3-9,11,14H,10,12-13H2,1-2H3,(H,31,36)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408685
PNG
(N-{[4-methoxy-2-(trifluoromethyl)phenyl]methyl}-1-...)
Show SMILES COc1ccc(CNC(=O)c2cn(Cc3ccc(Cn4cc(C)cn4)cc3)nc2C(F)(F)F)c(c1)C(F)(F)F
Show InChI InChI=1S/C26H23F6N5O2/c1-16-10-34-36(12-16)13-17-3-5-18(6-4-17)14-37-15-21(23(35-37)26(30,31)32)24(38)33-11-19-7-8-20(39-2)9-22(19)25(27,28)29/h3-10,12,15H,11,13-14H2,1-2H3,(H,33,38)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408695
PNG
(N-[(3-chloro-2-fluorophenyl)methyl]-1-({4-[(4-meth...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4cccc(Cl)c4F)c(n3)C(F)(F)F)cc2)c1
Show InChI InChI=1S/C24H20ClF4N5O/c1-15-9-31-33(11-15)12-16-5-7-17(8-6-16)13-34-14-19(22(32-34)24(27,28)29)23(35)30-10-18-3-2-4-20(25)21(18)26/h2-9,11,14H,10,12-13H2,1H3,(H,30,35)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408708
PNG
(N-[(2-fluoro-4-methylphenyl)methyl]-1-({4-[(4-meth...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4ccc(C)cc4F)c(n3)C(F)(F)F)cc2)c1
Show InChI InChI=1S/C25H23F4N5O/c1-16-3-8-20(22(26)9-16)11-30-24(35)21-15-34(32-23(21)25(27,28)29)14-19-6-4-18(5-7-19)13-33-12-17(2)10-31-33/h3-10,12,15H,11,13-14H2,1-2H3,(H,30,35)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408709
PNG
(N-[(3-fluoropyridin-2-yl)methyl]-1-({4-[(4-methylp...)
Show SMILES Cc1cn(Cc2ncccc2F)nc1Cc1ccc(CNC(=O)c2c[nH]nc2C(F)(F)F)cc1
Show InChI InChI=1S/C23H20F4N6O/c1-14-12-33(13-20-18(24)3-2-8-28-20)32-19(14)9-15-4-6-16(7-5-15)10-29-22(34)17-11-30-31-21(17)23(25,26)27/h2-8,11-12H,9-10,13H2,1H3,(H,29,34)(H,30,31)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408712
PNG
(3-(methoxymethyl)-N-[(6-methylpyridin-3-yl)methyl]...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1ccc(C)nc1
Show InChI InChI=1S/C26H27N5O3/c1-19-6-7-22(13-27-19)14-28-26(33)23-17-31(29-24(23)18-34-2)16-21-10-8-20(9-11-21)15-30-12-4-3-5-25(30)32/h3-13,17H,14-16,18H2,1-2H3,(H,28,33)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408719
PNG
(N-[(5-chloro-1-benzothiophen-3-yl)methyl]-3-(metho...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1csc2ccc(Cl)cc12
Show InChI InChI=1S/C28H25ClN4O3S/c1-36-17-25-24(28(35)30-13-21-18-37-26-10-9-22(29)12-23(21)26)16-33(31-25)15-20-7-5-19(6-8-20)14-32-11-3-2-4-27(32)34/h2-12,16,18H,13-15,17H2,1H3,(H,30,35)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408734
PNG
( N-[(2-fluoro-3-methoxyphenyl)methyl]-3-(methoxyme...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cccc(OC)c1F
Show InChI InChI=1S/C27H27FN4O4/c1-35-18-23-22(27(34)29-14-21-6-5-7-24(36-2)26(21)28)17-32(30-23)16-20-11-9-19(10-12-20)15-31-13-4-3-8-25(31)33/h3-13,17H,14-16,18H2,1-2H3,(H,29,34)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408742
PNG
( 3-(methoxymethyl)-1-({4-[(2-oxopyridin-1-yl)methy...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1ccccc1C(F)(F)F
Show InChI InChI=1S/C27H25F3N4O3/c1-37-18-24-22(26(36)31-14-21-6-2-3-7-23(21)27(28,29)30)17-34(32-24)16-20-11-9-19(10-12-20)15-33-13-5-4-8-25(33)35/h2-13,17H,14-16,18H2,1H3,(H,31,36)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408747
PNG
( N-[(3-chloro-5-methoxyphenyl)methyl]-3-(methoxyme...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cc(Cl)cc(OC)c1
Show InChI InChI=1S/C27H27ClN4O4/c1-35-18-25-24(27(34)29-14-21-11-22(28)13-23(12-21)36-2)17-32(30-25)16-20-8-6-19(7-9-20)15-31-10-4-3-5-26(31)33/h3-13,17H,14-16,18H2,1-2H3,(H,29,34)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408757
PNG
( N-[(3-chloro-2,6-difluorophenyl)methyl]-3-(methox...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1c(F)ccc(Cl)c1F
Show InChI InChI=1S/C26H23ClF2N4O3/c1-36-16-23-20(26(35)30-12-19-22(28)10-9-21(27)25(19)29)15-33(31-23)14-18-7-5-17(6-8-18)13-32-11-3-2-4-24(32)34/h2-11,15H,12-14,16H2,1H3,(H,30,35)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408782
PNG
( N-{[3-(difluoromethoxy)phenyl]methyl}-3-(methoxym...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cccc(OC(F)F)c1
Show InChI InChI=1S/C27H26F2N4O4/c1-36-18-24-23(26(35)30-14-21-5-4-6-22(13-21)37-27(28)29)17-33(31-24)16-20-10-8-19(9-11-20)15-32-12-3-2-7-25(32)34/h2-13,17,27H,14-16,18H2,1H3,(H,30,35)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408784
PNG
( N-[(2,5-difluorophenyl)methyl]-3-(methoxymethyl)-...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cc(F)ccc1F
Show InChI InChI=1S/C26H24F2N4O3/c1-35-17-24-22(26(34)29-13-20-12-21(27)9-10-23(20)28)16-32(30-24)15-19-7-5-18(6-8-19)14-31-11-3-2-4-25(31)33/h2-12,16H,13-15,17H2,1H3,(H,29,34)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408796
PNG
( N-[(2-fluoro-3-methoxyphenyl)methyl]-3-(methoxyme...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccncc3=O)cc2)cc1C(=O)NCc1cccc(OC)c1F
Show InChI InChI=1S/C26H26FN5O4/c1-35-17-22-21(26(34)29-12-20-4-3-5-23(36-2)25(20)27)16-32(30-22)15-19-8-6-18(7-9-19)14-31-11-10-28-13-24(31)33/h3-11,13,16H,12,14-15,17H2,1-2H3,(H,29,34)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408797
PNG
(N-[(2,6-difluoro-3-methoxyphenyl)methyl]-3-(methox...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccc(C)cc3=O)cc2)cc1C(=O)NCc1c(F)ccc(OC)c1F
Show InChI InChI=1S/C28H28F2N4O4/c1-18-10-11-33(26(35)12-18)14-19-4-6-20(7-5-19)15-34-16-22(24(32-34)17-37-2)28(36)31-13-21-23(29)8-9-25(38-3)27(21)30/h4-12,16H,13-15,17H2,1-3H3,(H,31,36)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408678
PNG
(N-[(2-fluoro-5-methoxyphenyl)methyl]-1-({4-[(4-met...)
Show SMILES COc1ccc(F)c(CNC(=O)c2cn(Cc3ccc(Cn4cc(C)cn4)cc3)nc2C(F)(F)F)c1
Show InChI InChI=1S/C25H23F4N5O2/c1-16-10-31-33(12-16)13-17-3-5-18(6-4-17)14-34-15-21(23(32-34)25(27,28)29)24(35)30-11-19-9-20(36-2)7-8-22(19)26/h3-10,12,15H,11,13-14H2,1-2H3,(H,30,35)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408716
PNG
(3-(methoxymethyl)-N-[(6-methoxypyridin-2-yl)methyl...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cccc(OC)n1
Show InChI InChI=1S/C26H27N5O4/c1-34-18-23-22(26(33)27-14-21-6-5-7-24(28-21)35-2)17-31(29-23)16-20-11-9-19(10-12-20)15-30-13-4-3-8-25(30)32/h3-13,17H,14-16,18H2,1-2H3,(H,27,33)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408718
PNG
(N-[(3-fluoro-6-methoxypyridin-2-yl)methyl]-3-(meth...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1nc(OC)ccc1F
Show InChI InChI=1S/C26H26FN5O4/c1-35-17-23-20(26(34)28-13-22-21(27)10-11-24(29-22)36-2)16-32(30-23)15-19-8-6-18(7-9-19)14-31-12-4-3-5-25(31)33/h3-12,16H,13-15,17H2,1-2H3,(H,28,34)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408725
PNG
( N-[(5-chloro-1-benzothiophen-3-yl)methyl]-3-(meth...)
Show SMILES COCc1nn(Cc2ccc(Cn3cc(C)cn3)cc2)cc1C(=O)NCc1csc2ccc(Cl)cc12
Show InChI InChI=1S/C27H26ClN5O2S/c1-18-10-30-32(12-18)13-19-3-5-20(6-4-19)14-33-15-24(25(31-33)16-35-2)27(34)29-11-21-17-36-26-8-7-22(28)9-23(21)26/h3-10,12,15,17H,11,13-14,16H2,1-2H3,(H,29,34)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408746
PNG
( N-[(2,6-difluoro-3-methoxyphenyl)methyl]-3-(metho...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1c(F)ccc(OC)c1F
Show InChI InChI=1S/C27H26F2N4O4/c1-36-17-23-21(27(35)30-13-20-22(28)10-11-24(37-2)26(20)29)16-33(31-23)15-19-8-6-18(7-9-19)14-32-12-4-3-5-25(32)34/h3-12,16H,13-15,17H2,1-2H3,(H,30,35)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408780
PNG
( 2-({[3-(methoxymethyl)-1-({4-[(2-oxopyridin-1-yl)...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1ccccc1C(O)=O
Show InChI InChI=1S/C27H26N4O5/c1-36-18-24-23(26(33)28-14-21-6-2-3-7-22(21)27(34)35)17-31(29-24)16-20-11-9-19(10-12-20)15-30-13-5-4-8-25(30)32/h2-13,17H,14-16,18H2,1H3,(H,28,33)(H,34,35)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408783
PNG
(N-{[2-(difluoromethoxy)-6-fluorophenyl]methyl}-3-(...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1c(F)cccc1OC(F)F
Show InChI InChI=1S/C27H25F3N4O4/c1-37-17-23-21(26(36)31-13-20-22(28)5-4-6-24(20)38-27(29)30)16-34(32-23)15-19-10-8-18(9-11-19)14-33-12-3-2-7-25(33)35/h2-12,16,27H,13-15,17H2,1H3,(H,31,36)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408674
PNG
(1-({4-[(4-methylpyrazol-1-yl)methyl]phenyl}methyl)...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4cccc(OC(F)(F)F)c4)c(n3)C(F)(F)F)cc2)c1
Show InChI InChI=1S/C25H21F6N5O2/c1-16-10-33-35(12-16)13-17-5-7-18(8-6-17)14-36-15-21(22(34-36)24(26,27)28)23(37)32-11-19-3-2-4-20(9-19)38-25(29,30)31/h2-10,12,15H,11,13-14H2,1H3,(H,32,37)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408681
PNG
(N-[(2,4-dimethoxyphenyl)methyl]-1-({4-[(4-methylpy...)
Show SMILES COc1ccc(CNC(=O)c2cn(Cc3ccc(Cn4cc(C)cn4)cc3)nc2C(F)(F)F)c(OC)c1
Show InChI InChI=1S/C26H26F3N5O3/c1-17-11-31-33(13-17)14-18-4-6-19(7-5-18)15-34-16-22(24(32-34)26(27,28)29)25(35)30-12-20-8-9-21(36-2)10-23(20)37-3/h4-11,13,16H,12,14-15H2,1-3H3,(H,30,35)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408698
PNG
(N-[(2,6-dichlorophenyl)methyl]-1-({4-[(4-methylpyr...)
Show SMILES Cc1cn(Cc2c(Cl)cccc2Cl)nc1Cc1ccc(CNC(=O)c2c[nH]nc2C(F)(F)F)cc1
Show InChI InChI=1S/C24H20Cl2F3N5O/c1-14-12-34(13-18-19(25)3-2-4-20(18)26)33-21(14)9-15-5-7-16(8-6-15)10-30-23(35)17-11-31-32-22(17)24(27,28)29/h2-8,11-12H,9-10,13H2,1H3,(H,30,35)(H,31,32)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408707
PNG
(N-[(3-fluoro-2-methylphenyl)methyl]-1-({4-[(4-meth...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4cccc(F)c4C)c(n3)C(F)(F)F)cc2)c1
Show InChI InChI=1S/C25H23F4N5O/c1-16-10-31-33(12-16)13-18-6-8-19(9-7-18)14-34-15-21(23(32-34)25(27,28)29)24(35)30-11-20-4-3-5-22(26)17(20)2/h3-10,12,15H,11,13-14H2,1-2H3,(H,30,35)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408711
PNG
(3-(methoxymethyl)-1-({4-[(2-oxopyridin-1-yl)methyl...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cnccc1C(F)(F)F
Show InChI InChI=1S/C26H24F3N5O3/c1-37-17-23-21(25(36)31-13-20-12-30-10-9-22(20)26(27,28)29)16-34(32-23)15-19-7-5-18(6-8-19)14-33-11-3-2-4-24(33)35/h2-12,16H,13-15,17H2,1H3,(H,31,36)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408726
PNG
(N-[(2-carbamoylphenyl)methyl]-3-cyclopropyl-1-({4-...)
Show SMILES NC(=O)c1ccccc1CNC(=O)c1cn(Cc2ccc(Cn3ccccc3=O)cc2)nc1C1CC1
Show InChI InChI=1S/C28H27N5O3/c29-27(35)23-6-2-1-5-22(23)15-30-28(36)24-18-33(31-26(24)21-12-13-21)17-20-10-8-19(9-11-20)16-32-14-4-3-7-25(32)34/h1-11,14,18,21H,12-13,15-17H2,(H2,29,35)(H,30,36)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408755
PNG
( 3-acetamido-N-[(2-fluoro-3-methoxyphenyl)methyl]-...)
Show SMILES COc1cccc(CNC(=O)c2cn(Cc3ccc(Cn4ccccc4=O)cc3)nc2NC(C)=O)c1F
Show InChI InChI=1S/C27H26FN5O4/c1-18(34)30-26-22(27(36)29-14-21-6-5-7-23(37-2)25(21)28)17-33(31-26)16-20-11-9-19(10-12-20)15-32-13-4-3-8-24(32)35/h3-13,17H,14-16H2,1-2H3,(H,29,36)(H,30,31,34)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408756
PNG
(N-[(2-fluoro-3-methoxyphenyl)methyl]-3-(N-methylac...)
Show SMILES COc1cccc(CNC(=O)c2cn(Cc3ccc(Cn4ccccc4=O)cc3)nc2N(C)C(C)=O)c1F
Show InChI InChI=1S/C28H28FN5O4/c1-19(35)32(2)27-23(28(37)30-15-22-7-6-8-24(38-3)26(22)29)18-34(31-27)17-21-12-10-20(11-13-21)16-33-14-5-4-9-25(33)36/h4-14,18H,15-17H2,1-3H3,(H,30,37)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408789
PNG
(N-[(6-chloro-2-fluoro-3-methoxyphenyl)methyl]-3-(m...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1c(Cl)ccc(O)c1F
Show InChI InChI=1S/C26H24ClFN4O4/c1-36-16-22-20(26(35)29-12-19-21(27)9-10-23(33)25(19)28)15-32(30-22)14-18-7-5-17(6-8-18)13-31-11-3-2-4-24(31)34/h2-11,15,33H,12-14,16H2,1H3,(H,29,35)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408795
PNG
( 3-(methoxymethyl)-N-[(3-methoxyphenyl)methyl]-1-(...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cccc(OC)c1
Show InChI InChI=1S/C27H28N4O4/c1-34-19-25-24(27(33)28-15-22-6-5-7-23(14-22)35-2)18-31(29-25)17-21-11-9-20(10-12-21)16-30-13-4-3-8-26(30)32/h3-14,18H,15-17,19H2,1-2H3,(H,28,33)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408798
PNG
( N-[(2,6-difluoro-3-methoxyphenyl)methyl]-1-({4-[(...)
Show SMILES COCc1nn(Cc2ccc(Cn3cc(F)ccc3=O)cc2)cc1C(=O)NCc1c(F)ccc(OC)c1F
Show InChI InChI=1S/C27H25F3N4O4/c1-37-16-23-21(27(36)31-11-20-22(29)8-9-24(38-2)26(20)30)15-34(32-23)13-18-5-3-17(4-6-18)12-33-14-19(28)7-10-25(33)35/h3-10,14-15H,11-13,16H2,1-2H3,(H,31,36)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408799
PNG
(N-[(2,6-difluoro-3-methoxyphenyl)methyl]-1-({4-[(4...)
Show SMILES CCOc1ccn(Cc2ccc(Cn3cc(C(=O)NCc4c(F)ccc(OC)c4F)c(COC)n3)cc2)c(=O)c1
Show InChI InChI=1S/C29H30F2N4O5/c1-4-40-21-11-12-34(27(36)13-21)15-19-5-7-20(8-6-19)16-35-17-23(25(33-35)18-38-2)29(37)32-14-22-24(30)9-10-26(39-3)28(22)31/h5-13,17H,4,14-16,18H2,1-3H3,(H,32,37)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408692
PNG
(N-[(4-chloro-2,6-difluorophenyl)methyl]-1-({4-[(4-...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4c(F)cc(Cl)cc4F)c(n3)C(F)(F)F)cc2)c1
Show InChI InChI=1S/C24H19ClF5N5O/c1-14-8-32-34(10-14)11-15-2-4-16(5-3-15)12-35-13-19(22(33-35)24(28,29)30)23(36)31-9-18-20(26)6-17(25)7-21(18)27/h2-8,10,13H,9,11-12H2,1H3,(H,31,36)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408697
PNG
( N-{[3-chloro-2-fluoro-6-(trifluoromethyl)phenyl]m...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4c(F)c(Cl)ccc4C(F)(F)F)c(n3)C(F)(F)F)cc2)c1
Show InChI InChI=1S/C25H19ClF7N5O/c1-14-8-35-37(10-14)11-15-2-4-16(5-3-15)12-38-13-18(22(36-38)25(31,32)33)23(39)34-9-17-19(24(28,29)30)6-7-20(26)21(17)27/h2-8,10,13H,9,11-12H2,1H3,(H,34,39)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408705
PNG
( 1-({4-[(4-methylpyrazol-1-yl)methyl]phenyl}methyl...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4c(C)cc(C)cc4C)c(n3)C(F)(F)F)cc2)c1
Show InChI InChI=1S/C27H28F3N5O/c1-17-9-19(3)23(20(4)10-17)12-31-26(36)24-16-35(33-25(24)27(28,29)30)15-22-7-5-21(6-8-22)14-34-13-18(2)11-32-34/h5-11,13,16H,12,14-15H2,1-4H3,(H,31,36)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408710
PNG
(-[(4-chloropyridin-2-yl)methyl]-1-({4-[(4-methylpy...)
Show SMILES Cc1cn(Cc2cc(Cl)ccn2)nc1Cc1ccc(CNC(=O)c2c[nH]nc2C(F)(F)F)cc1
Show InChI InChI=1S/C23H20ClF3N6O/c1-14-12-33(13-18-9-17(24)6-7-28-18)32-20(14)8-15-2-4-16(5-3-15)10-29-22(34)19-11-30-31-21(19)23(25,26)27/h2-7,9,11-12H,8,10,13H2,1H3,(H,29,34)(H,30,31)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408712
PNG
(3-(methoxymethyl)-N-[(6-methylpyridin-3-yl)methyl]...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1ccc(C)nc1
Show InChI InChI=1S/C26H27N5O3/c1-19-6-7-22(13-27-19)14-28-26(33)23-17-31(29-24(23)18-34-2)16-21-10-8-20(9-11-21)15-30-12-4-3-5-25(30)32/h3-13,17H,14-16,18H2,1-2H3,(H,28,33)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408713
PNG
( 3-(methoxymethyl)-1-({4-[(2-oxopyridin-1-yl)methy...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cccnc1C(F)(F)F
Show InChI InChI=1S/C26H24F3N5O3/c1-37-17-22-21(25(36)31-13-20-5-4-11-30-24(20)26(27,28)29)16-34(32-22)15-19-9-7-18(8-10-19)14-33-12-3-2-6-23(33)35/h2-12,16H,13-15,17H2,1H3,(H,31,36)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408793
PNG
( methyl 2-({[3-(methoxymethyl)-1-({4-[(2-oxopyridi...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1ccccc1C(=O)OC
Show InChI InChI=1S/C28H28N4O5/c1-36-19-25-24(27(34)29-15-22-7-3-4-8-23(22)28(35)37-2)18-32(30-25)17-21-12-10-20(11-13-21)16-31-14-6-5-9-26(31)33/h3-14,18H,15-17,19H2,1-2H3,(H,29,34)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408667
PNG
(1-(7-Chloro-quinolin-3-ylmethyl)-3-methoxymethyl-1...)
Show SMILES COCc1nn(Cc2cnc3cc(Cl)ccc3c2)cc1C(=O)NCc1cccc(OC)c1F
Show InChI InChI=1S/C24H22ClFN4O3/c1-32-14-21-19(24(31)28-11-17-4-3-5-22(33-2)23(17)26)13-30(29-21)12-15-8-16-6-7-18(25)9-20(16)27-10-15/h3-10,13H,11-12,14H2,1-2H3,(H,28,31)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408668
PNG
(N-[(2-fluoro-3-methoxyphenyl)methyl]-1-({4-[(4-met...)
Show SMILES COc1cccc(CNC(=O)c2cn(Cc3ccc(Cn4cc(C)cn4)cc3)nc2C(F)(F)F)c1F
Show InChI InChI=1S/C25H23F4N5O2/c1-16-10-31-33(12-16)13-17-6-8-18(9-7-17)14-34-15-20(23(32-34)25(27,28)29)24(35)30-11-19-4-3-5-21(36-2)22(19)26/h3-10,12,15H,11,13-14H2,1-2H3,(H,30,35)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408671
PNG
(N-[(3-methoxyphenyl)methyl]-1-({4-[(4-methylpyrazo...)
Show SMILES COc1cccc(CNC(=O)c2cn(Cc3ccc(Cn4cc(C)cn4)cc3)nc2C(F)(F)F)c1
Show InChI InChI=1S/C25H24F3N5O2/c1-17-11-30-32(13-17)14-18-6-8-19(9-7-18)15-33-16-22(23(31-33)25(26,27)28)24(34)29-12-20-4-3-5-21(10-20)35-2/h3-11,13,16H,12,14-15H2,1-2H3,(H,29,34)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408676
PNG
(N-[(4-methylphenyl)methyl]-1-({4-[(4-methylpyrazol...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4ccc(C)cc4)c(n3)C(F)F)cc2)c1
Show InChI InChI=1S/C25H25F2N5O/c1-17-3-5-19(6-4-17)12-28-25(33)22-16-32(30-23(22)24(26)27)15-21-9-7-20(8-10-21)14-31-13-18(2)11-29-31/h3-11,13,16,24H,12,14-15H2,1-2H3,(H,28,33)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408704
PNG
(N-[(2,6-dimethylphenyl)methyl]-1-({4-[(4-methylpyr...)
Show SMILES Cc1cn(Cc2c(C)cccc2C)nc1Cc1ccc(CNC(=O)c2c[nH]nc2C(F)(F)F)cc1
Show InChI InChI=1S/C26H26F3N5O/c1-16-5-4-6-17(2)22(16)15-34-14-18(3)23(33-34)11-19-7-9-20(10-8-19)12-30-25(35)21-13-31-32-24(21)26(27,28)29/h4-10,13-14H,11-12,15H2,1-3H3,(H,30,35)(H,31,32)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Plasma kallikrein


(Homo sapiens (Human))
BDBM408707
PNG
(N-[(3-fluoro-2-methylphenyl)methyl]-1-({4-[(4-meth...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4cccc(F)c4C)c(n3)C(F)(F)F)cc2)c1
Show InChI InChI=1S/C25H23F4N5O/c1-16-10-31-33(12-16)13-18-6-8-19(9-7-18)14-34-15-21(23(32-34)25(27,28)29)24(35)30-11-20-4-3-5-22(26)17(20)2/h3-10,12,15H,11,13-14H2,1-2H3,(H,30,35)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408745
PNG
( N-[(2-fluoro-4-methylphenyl)methyl]-3-(methoxymet...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1ccc(C)cc1F
Show InChI InChI=1S/C27H27FN4O3/c1-19-6-11-22(24(28)13-19)14-29-27(34)23-17-32(30-25(23)18-35-2)16-21-9-7-20(8-10-21)15-31-12-4-3-5-26(31)33/h3-13,17H,14-16,18H2,1-2H3,(H,29,34)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408804
PNG
(N-[(2-fluoro-3-methoxyphenyl)methyl]-1-{[6-(pyrrol...)
Show SMILES COc1cccc(CNC(=O)c2cn(Cc3ccc(nc3)N3CCCC3)nc2C(F)(F)F)c1F
Show InChI InChI=1S/C23H23F4N5O2/c1-34-18-6-4-5-16(20(18)24)12-29-22(33)17-14-32(30-21(17)23(25,26)27)13-15-7-8-19(28-11-15)31-9-2-3-10-31/h4-8,11,14H,2-3,9-10,12-13H2,1H3,(H,29,33)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408666
PNG
(3-Amino-1-[4-(2-oxo-2H-pyridin-1-ylmethyl)-benzyl]...)
Show SMILES COc1cccc(CNC(=O)c2cn(Cc3ccc(Cn4ccccc4=O)cc3)nc2N)c1F
Show InChI InChI=1S/C25H24FN5O3/c1-34-21-6-4-5-19(23(21)26)13-28-25(33)20-16-31(29-24(20)27)15-18-10-8-17(9-11-18)14-30-12-3-2-7-22(30)32/h2-12,16H,13-15H2,1H3,(H2,27,29)(H,28,33)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408693
PNG
( N-[(4-chloro-2-fluorophenyl)methyl]-1-({4-[(4-met...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4ccc(Cl)cc4F)c(n3)C(F)(F)F)cc2)c1
Show InChI InChI=1S/C24H20ClF4N5O/c1-15-9-31-33(11-15)12-16-2-4-17(5-3-16)13-34-14-20(22(32-34)24(27,28)29)23(35)30-10-18-6-7-19(25)8-21(18)26/h2-9,11,14H,10,12-13H2,1H3,(H,30,35)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408696
PNG
(N-[(5-chloro-2-fluorophenyl)methyl]-1-({4-[(4-meth...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4cc(Cl)ccc4F)c(n3)C(F)(F)F)cc2)c1
Show InChI InChI=1S/C24H20ClF4N5O/c1-15-9-31-33(11-15)12-16-2-4-17(5-3-16)13-34-14-20(22(32-34)24(27,28)29)23(35)30-10-18-8-19(25)6-7-21(18)26/h2-9,11,14H,10,12-13H2,1H3,(H,30,35)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408720
PNG
(N-[(5-chloro-1-benzothiophen-3-yl)methyl]-3-(metho...)
Show SMILES COCc1nn(Cc2ccc(nc2)N2CCCC2)cc1C(=O)NCc1csc2ccc(Cl)cc12
Show InChI InChI=1S/C25H26ClN5O2S/c1-33-15-22-21(25(32)28-12-18-16-34-23-6-5-19(26)10-20(18)23)14-31(29-22)13-17-4-7-24(27-11-17)30-8-2-3-9-30/h4-7,10-11,14,16H,2-3,8-9,12-13,15H2,1H3,(H,28,32)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408730
PNG
(N-[(4-carbamoylphenyl)methyl]-3-cyclopropyl-1-({4-...)
Show SMILES NC(=O)c1ccc(CNC(=O)c2cn(Cc3ccc(Cn4ccccc4=O)cc3)nc2C2CC2)cc1
Show InChI InChI=1S/C28H27N5O3/c29-27(35)23-10-8-19(9-11-23)15-30-28(36)24-18-33(31-26(24)22-12-13-22)17-21-6-4-20(5-7-21)16-32-14-2-1-3-25(32)34/h1-11,14,18,22H,12-13,15-17H2,(H2,29,35)(H,30,36)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408738
PNG
( 3-(dimethylamino)-N-[(2-fluoro-3-methoxyphenyl)me...)
Show SMILES COc1cccc(CNC(=O)c2cn(Cc3ccc(Cn4ccccc4=O)cc3)nc2N(C)C)c1F
Show InChI InChI=1S/C27H28FN5O3/c1-31(2)26-22(27(35)29-15-21-7-6-8-23(36-3)25(21)28)18-33(30-26)17-20-12-10-19(11-13-20)16-32-14-5-4-9-24(32)34/h4-14,18H,15-17H2,1-3H3,(H,29,35)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408744
PNG
( N-[(2-fluoro-5-methoxyphenyl)methyl]-3-(methoxyme...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cc(OC)ccc1F
Show InChI InChI=1S/C27H27FN4O4/c1-35-18-25-23(27(34)29-14-21-13-22(36-2)10-11-24(21)28)17-32(30-25)16-20-8-6-19(7-9-20)15-31-12-4-3-5-26(31)33/h3-13,17H,14-16,18H2,1-2H3,(H,29,34)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408769
PNG
( N-{[3-methoxy-2-(trifluoromethyl)phenyl]methyl}-3...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cccc(OC)c1C(F)(F)F
Show InChI InChI=1S/C28H27F3N4O4/c1-38-18-23-22(27(37)32-14-21-6-5-7-24(39-2)26(21)28(29,30)31)17-35(33-23)16-20-11-9-19(10-12-20)15-34-13-4-3-8-25(34)36/h3-13,17H,14-16,18H2,1-2H3,(H,32,37)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408674
PNG
(1-({4-[(4-methylpyrazol-1-yl)methyl]phenyl}methyl)...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4cccc(OC(F)(F)F)c4)c(n3)C(F)(F)F)cc2)c1
Show InChI InChI=1S/C25H21F6N5O2/c1-16-10-33-35(12-16)13-17-5-7-18(8-6-17)14-36-15-21(22(34-36)24(26,27)28)23(37)32-11-19-3-2-4-20(9-19)38-25(29,30)31/h2-10,12,15H,11,13-14H2,1H3,(H,32,37)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408686
PNG
(N-[(2,6-difluorophenyl)methyl]-1-({4-[(4-methylpyr...)
Show SMILES Cc1cn(Cc2c(F)cccc2F)nc1Cc1ccc(CNC(=O)c2c[nH]nc2C(F)(F)F)cc1
Show InChI InChI=1S/C24H20F5N5O/c1-14-12-34(13-18-19(25)3-2-4-20(18)26)33-21(14)9-15-5-7-16(8-6-15)10-30-23(35)17-11-31-32-22(17)24(27,28)29/h2-8,11-12H,9-10,13H2,1H3,(H,30,35)(H,31,32)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408691
PNG
(N-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-1-(...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4c(F)cccc4C(F)(F)F)c(n3)C(F)(F)F)cc2)c1
Show InChI InChI=1S/C25H20F7N5O/c1-15-9-34-36(11-15)12-16-5-7-17(8-6-16)13-37-14-19(22(35-37)25(30,31)32)23(38)33-10-18-20(24(27,28)29)3-2-4-21(18)26/h2-9,11,14H,10,12-13H2,1H3,(H,33,38)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408694
PNG
(N-[(3-chloro-2,6-difluorophenyl)methyl]-1-({4-[(4-...)
Show SMILES Cc1cnn(Cc2ccc(Cn3cc(C(=O)NCc4c(F)ccc(Cl)c4F)c(n3)C(F)(F)F)cc2)c1
Show InChI InChI=1S/C24H19ClF5N5O/c1-14-8-32-34(10-14)11-15-2-4-16(5-3-15)12-35-13-18(22(33-35)24(28,29)30)23(36)31-9-17-20(26)7-6-19(25)21(17)27/h2-8,10,13H,9,11-12H2,1H3,(H,31,36)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408700
PNG
( N-[(2,4-dimethylphenyl)methyl]-1-({4-[(4-methylpy...)
Show SMILES Cc1cn(Cc2ccc(C)cc2C)nc1Cc1ccc(CNC(=O)c2c[nH]nc2C(F)(F)F)cc1
Show InChI InChI=1S/C26H26F3N5O/c1-16-4-9-21(17(2)10-16)15-34-14-18(3)23(33-34)11-19-5-7-20(8-6-19)12-30-25(35)22-13-31-32-24(22)26(27,28)29/h4-10,13-14H,11-12,15H2,1-3H3,(H,30,35)(H,31,32)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408737
PNG
(3-amino-1-({4-[(2-oxopyridin-1-yl)methyl]phenyl}me...)
Show SMILES Nc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C25H22F3N5O3/c26-25(27,28)36-20-10-8-17(9-11-20)13-30-24(35)21-16-33(31-23(21)29)15-19-6-4-18(5-7-19)14-32-12-2-1-3-22(32)34/h1-12,16H,13-15H2,(H2,29,31)(H,30,35)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408740
PNG
(N-[(2-fluorophenyl)methyl]-3-(methoxymethyl)-1-({4...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1ccccc1F
Show InChI InChI=1S/C26H25FN4O3/c1-34-18-24-22(26(33)28-14-21-6-2-3-7-23(21)27)17-31(29-24)16-20-11-9-19(10-12-20)15-30-13-5-4-8-25(30)32/h2-13,17H,14-16,18H2,1H3,(H,28,33)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408790
PNG
(N-[(2-fluoro-3-hydroxyphenyl)methyl]-3-(methoxymet...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cccc(O)c1F
Show InChI InChI=1S/C26H25FN4O4/c1-35-17-22-21(26(34)28-13-20-5-4-6-23(32)25(20)27)16-31(29-22)15-19-10-8-18(9-11-19)14-30-12-3-2-7-24(30)33/h2-12,16,32H,13-15,17H2,1H3,(H,28,34)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408805
PNG
( 3-amino-N-[(7-chloro-4-methyl-2,3-dihydro-1,4-ben...)
Show SMILES CN1CC(CNC(=O)c2cn(Cc3ccc(Cn4ccccc4=O)cc3)nc2N)Oc2cc(Cl)ccc12
Show InChI InChI=1S/C27H27ClN6O3/c1-32-16-21(37-24-12-20(28)9-10-23(24)32)13-30-27(36)22-17-34(31-26(22)29)15-19-7-5-18(6-8-19)14-33-11-3-2-4-25(33)35/h2-12,17,21H,13-16H2,1H3,(H2,29,31)(H,30,36)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408750
PNG
(N-{[2-(difluoromethyl)-3-methoxyphenyl]methyl}-3-(...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cccc(OC)c1C(F)F
Show InChI InChI=1S/C28H28F2N4O4/c1-37-18-23-22(28(36)31-14-21-6-5-7-24(38-2)26(21)27(29)30)17-34(32-23)16-20-11-9-19(10-12-20)15-33-13-4-3-8-25(33)35/h3-13,17,27H,14-16,18H2,1-2H3,(H,31,36)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408794
PNG
( N-[(3-ethyl-2-fluorophenyl)methyl]-3-(methoxymeth...)
Show SMILES CCc1cccc(CNC(=O)c2cn(Cc3ccc(Cn4ccccc4=O)cc3)nc2COC)c1F
Show InChI InChI=1S/C28H29FN4O3/c1-3-22-7-6-8-23(27(22)29)15-30-28(35)24-18-33(31-25(24)19-36-2)17-21-12-10-20(11-13-21)16-32-14-5-4-9-26(32)34/h4-14,18H,3,15-17,19H2,1-2H3,(H,30,35)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408733
PNG
( 3-cyclopropyl-N-[(2-fluoro-3-methoxyphenyl)methyl...)
Show SMILES COc1cccc(CNC(=O)c2cn(Cc3ccc(Cn4ccccc4=O)cc3)nc2C2CC2)c1F
Show InChI InChI=1S/C28H27FN4O3/c1-36-24-6-4-5-22(26(24)29)15-30-28(35)23-18-33(31-27(23)21-12-13-21)17-20-10-8-19(9-11-20)16-32-14-3-2-7-25(32)34/h2-11,14,18,21H,12-13,15-17H2,1H3,(H,30,35)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408781
PNG
( N-{[3-(difluoromethoxy)-2-fluorophenyl]methyl}-3-...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cccc(OC(F)F)c1F
Show InChI InChI=1S/C27H25F3N4O4/c1-37-17-22-21(26(36)31-13-20-5-4-6-23(25(20)28)38-27(29)30)16-34(32-22)15-19-10-8-18(9-11-19)14-33-12-3-2-7-24(33)35/h2-12,16,27H,13-15,17H2,1H3,(H,31,36)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408787
PNG
(N-[(2,5-difluoro-3-methoxyphenyl)methyl]-3-(methox...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cc(F)cc(OC)c1F
Show InChI InChI=1S/C27H26F2N4O4/c1-36-17-23-22(27(35)30-13-20-11-21(28)12-24(37-2)26(20)29)16-33(31-23)15-19-8-6-18(7-9-19)14-32-10-4-3-5-25(32)34/h3-12,16H,13-15,17H2,1-2H3,(H,30,35)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408806
PNG
(3-amino-N-[(7-chloro-3,4-dihydro-2H-1,4-benzoxazin...)
Show SMILES Nc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCC1CNc2ccc(Cl)cc2O1
Show InChI InChI=1S/C26H25ClN6O3/c27-19-8-9-22-23(11-19)36-20(12-29-22)13-30-26(35)21-16-33(31-25(21)28)15-18-6-4-17(5-7-18)14-32-10-2-1-3-24(32)34/h1-11,16,20,29H,12-15H2,(H2,28,31)(H,30,35)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408717
PNG
( N-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-3-(met...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1nccc(OC)c1F
Show InChI InChI=1S/C26H26FN5O4/c1-35-17-22-20(26(34)29-13-21-25(27)23(36-2)10-11-28-21)16-32(30-22)15-19-8-6-18(7-9-19)14-31-12-4-3-5-24(31)33/h3-12,16H,13-15,17H2,1-2H3,(H,29,34)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408768
PNG
(N-[(6-cyano-2-fluoro-3-methoxyphenyl)methyl]-3-(me...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1c(F)c(OC)ccc1C#N
Show InChI InChI=1S/C28H26FN5O4/c1-37-18-24-23(28(36)31-14-22-21(13-30)10-11-25(38-2)27(22)29)17-34(32-24)16-20-8-6-19(7-9-20)15-33-12-4-3-5-26(33)35/h3-12,17H,14-16,18H2,1-2H3,(H,31,36)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408792
PNG
( 3-amino-N-[(2-fluoro-3-hydroxyphenyl)methyl]-1-({...)
Show SMILES Nc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cccc(O)c1F
Show InChI InChI=1S/C24H22FN5O3/c25-22-18(4-3-5-20(22)31)12-27-24(33)19-15-30(28-23(19)26)14-17-9-7-16(8-10-17)13-29-11-2-1-6-21(29)32/h1-11,15,31H,12-14H2,(H2,26,28)(H,27,33)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408759
PNG
(N-[(5-chloro-2-cyanophenyl)methyl]-3-(methoxymethy...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cc(Cl)ccc1C#N
Show InChI InChI=1S/C27H24ClN5O3/c1-36-18-25-24(27(35)30-14-22-12-23(28)10-9-21(22)13-29)17-33(31-25)16-20-7-5-19(6-8-20)15-32-11-3-2-4-26(32)34/h2-12,17H,14-16,18H2,1H3,(H,30,35)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408772
PNG
( N-{[2-(difluoromethyl)-6-fluorophenyl]methyl}-3-(...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1c(F)cccc1C(F)F
Show InChI InChI=1S/C27H25F3N4O3/c1-37-17-24-22(27(36)31-13-21-20(26(29)30)5-4-6-23(21)28)16-34(32-24)15-19-10-8-18(9-11-19)14-33-12-3-2-7-25(33)35/h2-12,16,26H,13-15,17H2,1H3,(H,31,36)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408779
PNG
(N-[(2-carbamoyl-5-methoxyphenyl)methyl]-3-(methoxy...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cc(OC)ccc1C(N)=O
Show InChI InChI=1S/C28H29N5O5/c1-37-18-25-24(28(36)30-14-21-13-22(38-2)10-11-23(21)27(29)35)17-33(31-25)16-20-8-6-19(7-9-20)15-32-12-4-3-5-26(32)34/h3-13,17H,14-16,18H2,1-2H3,(H2,29,35)(H,30,36)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408770
PNG
( N-{[5-methoxy-2-(trifluoromethyl)phenyl]methyl}-3...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cc(OC)ccc1C(F)(F)F
Show InChI InChI=1S/C28H27F3N4O4/c1-38-18-25-23(27(37)32-14-21-13-22(39-2)10-11-24(21)28(29,30)31)17-35(33-25)16-20-8-6-19(7-9-20)15-34-12-4-3-5-26(34)36/h3-13,17H,14-16,18H2,1-2H3,(H,32,37)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408778
PNG
( N-[(2-carbamoyl-6-fluorophenyl)methyl]-3-(methoxy...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1c(F)cccc1C(N)=O
Show InChI InChI=1S/C27H26FN5O4/c1-37-17-24-22(27(36)30-13-21-20(26(29)35)5-4-6-23(21)28)16-33(31-24)15-19-10-8-18(9-11-19)14-32-12-3-2-7-25(32)34/h2-12,16H,13-15,17H2,1H3,(H2,29,35)(H,30,36)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408736
PNG
( N-[(2-fluoro-3,6-dimethoxyphenyl)methyl]-3-(metho...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1c(OC)ccc(OC)c1F
Show InChI InChI=1S/C28H29FN4O5/c1-36-18-23-22(28(35)30-14-21-24(37-2)11-12-25(38-3)27(21)29)17-33(31-23)16-20-9-7-19(8-10-20)15-32-13-5-4-6-26(32)34/h4-13,17H,14-16,18H2,1-3H3,(H,30,35)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408773
PNG
( N-{[2-(difluoromethyl)-5-methoxyphenyl]methyl}-3-...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cc(OC)ccc1C(F)F
Show InChI InChI=1S/C28H28F2N4O4/c1-37-18-25-24(28(36)31-14-21-13-22(38-2)10-11-23(21)27(29)30)17-34(32-25)16-20-8-6-19(7-9-20)15-33-12-4-3-5-26(33)35/h3-13,17,27H,14-16,18H2,1-2H3,(H,31,36)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408775
PNG
( N-{[2-(difluoromethyl)-6-fluoro-3-methoxyphenyl]m...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1c(F)ccc(OC)c1C(F)F
Show InChI InChI=1S/C28H27F3N4O4/c1-38-17-23-21(28(37)32-13-20-22(29)10-11-24(39-2)26(20)27(30)31)16-35(33-23)15-19-8-6-18(7-9-19)14-34-12-4-3-5-25(34)36/h3-12,16,27H,13-15,17H2,1-2H3,(H,32,37)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408786
PNG
(N-[(3-fluoro-5-methoxyphenyl)methyl]-3-(methoxymet...)
Show SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cc(F)cc(OC)c1
Show InChI InChI=1S/C27H27FN4O4/c1-35-18-25-24(27(34)29-14-21-11-22(28)13-23(12-21)36-2)17-32(30-25)16-20-8-6-19(7-9-20)15-31-10-4-3-5-26(31)33/h3-13,17H,14-16,18H2,1-2H3,(H,29,34)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
Kallikrein 1


(Homo sapiens (Human))
BDBM408732
PNG
( N-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-1-...)
Show SMILES Fc1cccc(c1CNC(=O)c1cn(Cc2ccc(Cn3ccccc3=O)cc2)nc1C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C26H19F7N4O2/c27-21-5-3-4-20(25(28,29)30)18(21)12-34-24(39)19-15-37(35-23(19)26(31,32)33)14-17-9-7-16(8-10-17)13-36-11-2-1-6-22(36)38/h1-11,15H,12-14H2,(H,34,39)
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Kalvista Pharmaceuticals Limited

US Patent


Assay Description
KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25 C. with the fluorog...


US Patent US10364238 (2019)


BindingDB Entry DOI: 10.7270/Q2J968QP
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%