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Patent code US10370333

Compile Data Set for Download or QSAR
Found 169 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409772
PNG
(US10370333, Example I-1 | US10370333, Example XIII...)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cccnc1
Show InChI InChI=1S/C12H11ClN2O3S/c1-18-11-5-4-9(13)7-12(11)19(16,17)15-10-3-2-6-14-8-10/h2-8,15H,1H3
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n/an/a<100n/an/an/an/an/an/a



SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409952
PNG
(US10370333, Example XIII-4)
Show SMILES COC(=O)c1cncc(NS(=O)(=O)c2cc(F)ccc2OC(F)(F)F)c1
Show InChI InChI=1S/C14H10F4N2O5S/c1-24-13(21)8-4-10(7-19-6-8)20-26(22,23)12-5-9(15)2-3-11(12)25-14(16,17)18/h2-7,20H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409772
PNG
(US10370333, Example I-1 | US10370333, Example XIII...)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cccnc1
Show InChI InChI=1S/C12H11ClN2O3S/c1-18-11-5-4-9(13)7-12(11)19(16,17)15-10-3-2-6-14-8-10/h2-8,15H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409773
PNG
(US10370333, Example I-2)
Show SMILES COc1ccc(cc1S(=O)(=O)Nc1cccnc1)C(F)(F)F
Show InChI InChI=1S/C13H11F3N2O3S/c1-21-11-5-4-9(13(14,15)16)7-12(11)22(19,20)18-10-3-2-6-17-8-10/h2-8,18H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409842
PNG
(US10370333, Example IV-11)
Show SMILES COC(=O)c1cncc(NS(=O)(=O)c2cc(OC)ccc2OC)c1
Show InChI InChI=1S/C15H16N2O6S/c1-21-12-4-5-13(22-2)14(7-12)24(19,20)17-11-6-10(8-16-9-11)15(18)23-3/h4-9,17H,1-3H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409845
PNG
(US10370333, Example IV-18)
Show SMILES CCNC(=O)c1cncc(NS(=O)(=O)c2cc(Br)ccc2OC)c1
Show InChI InChI=1S/C15H16BrN3O4S/c1-3-18-15(20)10-6-12(9-17-8-10)19-24(21,22)14-7-11(16)4-5-13(14)23-2/h4-9,19H,3H2,1-2H3,(H,18,20)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM50299530
PNG
(5-fluoro-2-methoxy-N-(pyridin-3-yl)benzenesulfonam...)
Show SMILES COc1ccc(F)cc1S(=O)(=O)Nc1cccnc1
Show InChI InChI=1S/C12H11FN2O3S/c1-18-11-5-4-9(13)7-12(11)19(16,17)15-10-3-2-6-14-8-10/h2-8,15H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409784
PNG
(US10370333, Example II-15)
Show SMILES CNC(=O)c1ccc(OC)c(c1)S(=O)(=O)Nc1cnc2ccccc2c1
Show InChI InChI=1S/C18H17N3O4S/c1-19-18(22)13-7-8-16(25-2)17(10-13)26(23,24)21-14-9-12-5-3-4-6-15(12)20-11-14/h3-11,21H,1-2H3,(H,19,22)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409820
PNG
(US10370333, Example III-64)
Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)Nc1cncc(c1)-c1ccncc1
Show InChI InChI=1S/C18H17N3O4S/c1-24-16-3-4-17(25-2)18(10-16)26(22,23)21-15-9-14(11-20-12-15)13-5-7-19-8-6-13/h3-12,21H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409791
PNG
(US10370333, Example III-9)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cncc(c1)-c1ccc(O)cc1
Show InChI InChI=1S/C18H15ClN2O4S/c1-25-17-7-4-14(19)9-18(17)26(23,24)21-15-8-13(10-20-11-15)12-2-5-16(22)6-3-12/h2-11,21-22H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409833
PNG
(US10370333, Example IV-1 | US10370333, Example IV-...)
Show SMILES COC(=O)c1cncc(NS(=O)(=O)c2cc(Br)ccc2OC)c1
Show InChI InChI=1S/C14H13BrN2O5S/c1-21-12-4-3-10(15)6-13(12)23(19,20)17-11-5-9(7-16-8-11)14(18)22-2/h3-8,17H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409848
PNG
(US10370333, Example IV-21)
Show SMILES COCCNC(=O)c1cncc(NS(=O)(=O)c2cc(Br)ccc2OC)c1
Show InChI InChI=1S/C16H18BrN3O5S/c1-24-6-5-19-16(21)11-7-13(10-18-9-11)20-26(22,23)15-8-12(17)3-4-14(15)25-2/h3-4,7-10,20H,5-6H2,1-2H3,(H,19,21)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM45881
PNG
(5-bromanyl-2-methoxy-N-pyridin-3-yl-benzenesulfona...)
Show SMILES COc1ccc(Br)cc1S(=O)(=O)Nc1cccnc1
Show InChI InChI=1S/C12H11BrN2O3S/c1-18-11-5-4-9(13)7-12(11)19(16,17)15-10-3-2-6-14-8-10/h2-8,15H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM45881
PNG
(5-bromanyl-2-methoxy-N-pyridin-3-yl-benzenesulfona...)
Show SMILES COc1ccc(Br)cc1S(=O)(=O)Nc1cccnc1
Show InChI InChI=1S/C12H11BrN2O3S/c1-18-11-5-4-9(13)7-12(11)19(16,17)15-10-3-2-6-14-8-10/h2-8,15H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409834
PNG
(US10370333, Example IV-2)
Show SMILES CCOC(=O)c1cncc(NS(=O)(=O)c2cc(Br)ccc2OC)c1
Show InChI InChI=1S/C15H15BrN2O5S/c1-3-23-15(19)10-6-12(9-17-8-10)18-24(20,21)14-7-11(16)4-5-13(14)22-2/h4-9,18H,3H2,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409838
PNG
(US10370333, Example IV-7)
Show SMILES CCOC(=O)c1cncc(NS(=O)(=O)c2cc(Cl)ccc2OC)c1
Show InChI InChI=1S/C15H15ClN2O5S/c1-3-23-15(19)10-6-12(9-17-8-10)18-24(20,21)14-7-11(16)4-5-13(14)22-2/h4-9,18H,3H2,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409833
PNG
(US10370333, Example IV-1 | US10370333, Example IV-...)
Show SMILES COC(=O)c1cncc(NS(=O)(=O)c2cc(Br)ccc2OC)c1
Show InChI InChI=1S/C14H13BrN2O5S/c1-21-12-4-3-10(15)6-13(12)23(19,20)17-11-5-9(7-16-8-11)14(18)22-2/h3-8,17H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409886
PNG
(US10370333, Example IX-14)
Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)Nc1cnc2ccc(cc2c1)C(=O)NC1CCCCC1
Show InChI InChI=1S/C24H27N3O5S/c1-31-20-9-11-22(32-2)23(14-20)33(29,30)27-19-13-17-12-16(8-10-21(17)25-15-19)24(28)26-18-6-4-3-5-7-18/h8-15,18,27H,3-7H2,1-2H3,(H,26,28)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409888
PNG
(US10370333, Example IX-16)
Show SMILES COc1ccc(Br)cc1S(=O)(=O)Nc1cnc2ccc(COS(C)(=O)=O)cc2c1
Show InChI InChI=1S/C18H17BrN2O6S2/c1-26-17-6-4-14(19)9-18(17)29(24,25)21-15-8-13-7-12(11-27-28(2,22)23)3-5-16(13)20-10-15/h3-10,21H,11H2,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409938
PNG
(US10370333, Example XII-13)
Show SMILES NC(=O)c1cncc(NS(=O)(=O)c2cc(Br)ccc2OC(F)(F)F)c1
Show InChI InChI=1S/C13H9BrF3N3O4S/c14-8-1-2-10(24-13(15,16)17)11(4-8)25(22,23)20-9-3-7(12(18)21)5-19-6-9/h1-6,20H,(H2,18,21)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409944
PNG
(US10370333, Example XII-19)
Show SMILES COc1ccc(OC(F)(F)F)cc1S(=O)(=O)Nc1cncc(c1)C(N)=O
Show InChI InChI=1S/C14H12F3N3O5S/c1-24-11-3-2-10(25-14(15,16)17)5-12(11)26(22,23)20-9-4-8(13(18)21)6-19-7-9/h2-7,20H,1H3,(H2,18,21)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409956
PNG
(US10370333, Example XIII-8)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cncc(c1)-c1cnc(OC)nc1
Show InChI InChI=1S/C17H15ClN4O4S/c1-25-15-4-3-13(18)6-16(15)27(23,24)22-14-5-11(7-19-10-14)12-8-20-17(26-2)21-9-12/h3-10,22H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409963
PNG
(US10370333, Example T1.L-3)
Show SMILES COc1cc(Cl)c(Br)cc1S(=O)(=O)Nc1cccnc1
Show InChI InChI=1S/C12H10BrClN2O3S/c1-19-11-6-10(14)9(13)5-12(11)20(17,18)16-8-3-2-4-15-7-8/h2-7,16H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409789
PNG
(US10370333, Example III-7)
Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)Nc1cncc(c1)-c1ccc(O)cc1
Show InChI InChI=1S/C19H18N2O5S/c1-25-17-7-8-18(26-2)19(10-17)27(23,24)21-15-9-14(11-20-12-15)13-3-5-16(22)6-4-13/h3-12,21-22H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409879
PNG
(US10370333, Example IX-7)
Show SMILES CNC(=O)c1ccc2ncc(NS(=O)(=O)c3cc(Br)ccc3OC)cc2c1
Show InChI InChI=1S/C18H16BrN3O4S/c1-20-18(23)11-3-5-15-12(7-11)8-14(10-21-15)22-27(24,25)17-9-13(19)4-6-16(17)26-2/h3-10,22H,1-2H3,(H,20,23)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409887
PNG
(US10370333, Example IX-15)
Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)Nc1cnc2ccc(COS(C)(=O)=O)cc2c1
Show InChI InChI=1S/C19H20N2O7S2/c1-26-16-5-7-18(27-2)19(10-16)30(24,25)21-15-9-14-8-13(12-28-29(3,22)23)4-6-17(14)20-11-15/h4-11,21H,12H2,1-3H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409954
PNG
(US10370333, Example XIII-6)
Show SMILES COc1ccc(Br)cc1S(=O)(=O)Nc1cncc(c1)-c1cnc(OC)nc1
Show InChI InChI=1S/C17H15BrN4O4S/c1-25-15-4-3-13(18)6-16(15)27(23,24)22-14-5-11(7-19-10-14)12-8-20-17(26-2)21-9-12/h3-10,22H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM46004
PNG
(5-chloranyl-2-methoxy-N-quinolin-3-yl-benzenesulfo...)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2ccccc2c1
Show InChI InChI=1S/C16H13ClN2O3S/c1-22-15-7-6-12(17)9-16(15)23(20,21)19-13-8-11-4-2-3-5-14(11)18-10-13/h2-10,19H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409828
PNG
(US10370333, Example III-88)
Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)Nc1cncc(c1)-c1cnn(C)c1
Show InChI InChI=1S/C17H18N4O4S/c1-21-11-13(9-19-21)12-6-14(10-18-8-12)20-26(22,23)17-7-15(24-2)4-5-16(17)25-3/h4-11,20H,1-3H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409829
PNG
(US10370333, Example III-89)
Show SMILES COc1ccc(Br)cc1S(=O)(=O)Nc1cncc(c1)-c1cnn(C)c1
Show InChI InChI=1S/C16H15BrN4O3S/c1-21-10-12(8-19-21)11-5-14(9-18-7-11)20-25(22,23)16-6-13(17)3-4-15(16)24-2/h3-10,20H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409830
PNG
(US10370333, Example III-90)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cncc(c1)-c1cnn(C)c1
Show InChI InChI=1S/C16H15ClN4O3S/c1-21-10-12(8-19-21)11-5-14(9-18-7-11)20-25(22,23)16-6-13(17)3-4-15(16)24-2/h3-10,20H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409833
PNG
(US10370333, Example IV-1 | US10370333, Example IV-...)
Show SMILES COC(=O)c1cncc(NS(=O)(=O)c2cc(Br)ccc2OC)c1
Show InChI InChI=1S/C14H13BrN2O5S/c1-21-12-4-3-10(15)6-13(12)23(19,20)17-11-5-9(7-16-8-11)14(18)22-2/h3-8,17H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409953
PNG
(US10370333, Example XIII-5)
Show SMILES COc1ccc(F)cc1S(=O)(=O)Nc1cncc(c1)C(N)=O
Show InChI InChI=1S/C13H12FN3O4S/c1-21-11-3-2-9(14)5-12(11)22(19,20)17-10-4-8(13(15)18)6-16-7-10/h2-7,17H,1H3,(H2,15,18)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409955
PNG
(US10370333, Example XIII-7)
Show SMILES COc1ccc(F)cc1S(=O)(=O)Nc1cncc(c1)-c1cnc(OC)nc1
Show InChI InChI=1S/C17H15FN4O4S/c1-25-15-4-3-13(18)6-16(15)27(23,24)22-14-5-11(7-19-10-14)12-8-20-17(26-2)21-9-12/h3-10,22H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409775
PNG
(US10370333, Example I-4)
Show SMILES COc1cc(C)ccc1S(=O)(=O)Nc1cccnc1
Show InChI InChI=1S/C13H14N2O3S/c1-10-5-6-13(12(8-10)18-2)19(16,17)15-11-4-3-7-14-9-11/h3-9,15H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409790
PNG
(US10370333, Example III-8)
Show SMILES COc1ccc(Br)cc1S(=O)(=O)Nc1cncc(c1)-c1ccc(O)cc1
Show InChI InChI=1S/C18H15BrN2O4S/c1-25-17-7-4-14(19)9-18(17)26(23,24)21-15-8-13(10-20-11-15)12-2-5-16(22)6-3-12/h2-11,21-22H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409855
PNG
(US10370333, Example IV-26)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cncc(c1)C(N)=O
Show InChI InChI=1S/C13H12ClN3O4S/c1-21-11-3-2-9(14)5-12(11)22(19,20)17-10-4-8(13(15)18)6-16-7-10/h2-7,17H,1H3,(H2,15,18)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409890
PNG
(US10370333, Example X-6)
Show SMILES COc1ccc(OC(F)(F)F)cc1S(=O)(=O)Nc1cnc2ccccc2c1
Show InChI InChI=1S/C17H13F3N2O4S/c1-25-15-7-6-13(26-17(18,19)20)9-16(15)27(23,24)22-12-8-11-4-2-3-5-14(11)21-10-12/h2-10,22H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409823
PNG
(US10370333, Example III-72)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cncc(c1)-c1ccoc1
Show InChI InChI=1S/C16H13ClN2O4S/c1-22-15-3-2-13(17)7-16(15)24(20,21)19-14-6-12(8-18-9-14)11-4-5-23-10-11/h2-10,19H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409815
PNG
(US10370333, Example III-33 | US10370333, Example X...)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cncc(c1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C19H14ClN3O3S/c1-26-18-7-6-16(20)9-19(18)27(24,25)23-17-8-15(11-22-12-17)14-4-2-13(10-21)3-5-14/h2-9,11-12,23H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409809
PNG
(US10370333, Example III-23)
Show SMILES COc1ccc(Br)cc1S(=O)(=O)Nc1cncc(c1)-c1ccc(Br)cc1
Show InChI InChI=1S/C18H14Br2N2O3S/c1-25-17-7-6-15(20)9-18(17)26(23,24)22-16-8-13(10-21-11-16)12-2-4-14(19)5-3-12/h2-11,22H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409847
PNG
(US10370333, Example IV-20)
Show SMILES COc1ccc(Br)cc1S(=O)(=O)Nc1cncc(c1)C(=O)NC1CCCCC1
Show InChI InChI=1S/C19H22BrN3O4S/c1-27-17-8-7-14(20)10-18(17)28(25,26)23-16-9-13(11-21-12-16)19(24)22-15-5-3-2-4-6-15/h7-12,15,23H,2-6H2,1H3,(H,22,24)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409884
PNG
(US10370333, Example IX-12)
Show SMILES CCCNC(=O)c1ccc2ncc(NS(=O)(=O)c3cc(OC)ccc3OC)cc2c1
Show InChI InChI=1S/C21H23N3O5S/c1-4-9-22-21(25)14-5-7-18-15(10-14)11-16(13-23-18)24-30(26,27)20-12-17(28-2)6-8-19(20)29-3/h5-8,10-13,24H,4,9H2,1-3H3,(H,22,25)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409921
PNG
(US10370333, Example XI-28)
Show SMILES FC(F)(F)Oc1ccc(Cl)cc1S(=O)(=O)Nc1cncc(c1)-c1cscn1
Show InChI InChI=1S/C15H9ClF3N3O3S2/c16-10-1-2-13(25-15(17,18)19)14(4-10)27(23,24)22-11-3-9(5-20-6-11)12-7-26-8-21-12/h1-8,22H
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409958
PNG
(US10370333, Example XIII-10)
Show SMILES COc1ccc(cn1)-c1cncc(NS(=O)(=O)c2cc(F)ccc2OC)c1
Show InChI InChI=1S/C18H16FN3O4S/c1-25-16-5-4-14(19)8-17(16)27(23,24)22-15-7-13(9-20-11-15)12-3-6-18(26-2)21-10-12/h3-11,22H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409788
PNG
(US10370333, Example III-3 | US10370333, Example XI...)
Show SMILES COc1ccc(cc1)-c1cncc(NS(=O)(=O)c2cc(Cl)ccc2OC)c1
Show InChI InChI=1S/C19H17ClN2O4S/c1-25-17-6-3-13(4-7-17)14-9-16(12-21-11-14)22-27(23,24)19-10-15(20)5-8-18(19)26-2/h3-12,22H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409961
PNG
(US10370333, Example XIII-13)
Show SMILES COc1ccc(F)cc1S(=O)(=O)Nc1cncc(c1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C19H14FN3O3S/c1-26-18-7-6-16(20)9-19(18)27(24,25)23-17-8-15(11-22-12-17)14-4-2-13(10-21)3-5-14/h2-9,11-12,23H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409825
PNG
(US10370333, Example III-76)
Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)Nc1cncc(c1)-c1ccsc1
Show InChI InChI=1S/C17H16N2O4S2/c1-22-15-3-4-16(23-2)17(8-15)25(20,21)19-14-7-13(9-18-10-14)12-5-6-24-11-12/h3-11,19H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409837
PNG
(US10370333, Example IV-4)
Show SMILES COc1ccc(Br)cc1S(=O)(=O)Nc1cncc(c1)C(=O)OC1CCCCC1
Show InChI InChI=1S/C19H21BrN2O5S/c1-26-17-8-7-14(20)10-18(17)28(24,25)22-15-9-13(11-21-12-15)19(23)27-16-5-3-2-4-6-16/h7-12,16,22H,2-6H2,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409846
PNG
(US10370333, Example IV-19)
Show SMILES CCCNC(=O)c1cncc(NS(=O)(=O)c2cc(Br)ccc2OC)c1
Show InChI InChI=1S/C16H18BrN3O4S/c1-3-6-19-16(21)11-7-13(10-18-9-11)20-25(22,23)15-8-12(17)4-5-14(15)24-2/h4-5,7-10,20H,3,6H2,1-2H3,(H,19,21)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409869
PNG
(US10370333, Example VIII-4)
Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)Nc1ccc(N)nc1
Show InChI InChI=1S/C13H15N3O4S/c1-19-10-4-5-11(20-2)12(7-10)21(17,18)16-9-3-6-13(14)15-8-9/h3-8,16H,1-2H3,(H2,14,15)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409926
PNG
(US10370333, Example XII-1)
Show SMILES COC(=O)c1cncc(NS(=O)(=O)c2cc(Cl)ccc2OC(F)(F)F)c1
Show InChI InChI=1S/C14H10ClF3N2O5S/c1-24-13(21)8-4-10(7-19-6-8)20-26(22,23)12-5-9(15)2-3-11(12)25-14(16,17)18/h2-7,20H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409927
PNG
(US10370333, Example XII-2)
Show SMILES OC(=O)c1cncc(NS(=O)(=O)c2cc(Cl)ccc2OC(F)(F)F)c1
Show InChI InChI=1S/C13H8ClF3N2O5S/c14-8-1-2-10(24-13(15,16)17)11(4-8)25(22,23)19-9-3-7(12(20)21)5-18-6-9/h1-6,19H,(H,20,21)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409814
PNG
(US10370333, Example III-31)
Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)Nc1cncc(c1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C20H17N3O4S/c1-26-18-7-8-19(27-2)20(10-18)28(24,25)23-17-9-16(12-22-13-17)15-5-3-14(11-21)4-6-15/h3-10,12-13,23H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409819
PNG
(US10370333, Example III-61)
Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)Nc1cncc(c1)-c1cccnc1
Show InChI InChI=1S/C18H17N3O4S/c1-24-16-5-6-17(25-2)18(9-16)26(22,23)21-15-8-14(11-20-12-15)13-4-3-7-19-10-13/h3-12,21H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409821
PNG
(US10370333, Example III-70)
Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)Nc1cncc(c1)-c1ccoc1
Show InChI InChI=1S/C17H16N2O5S/c1-22-15-3-4-16(23-2)17(8-15)25(20,21)19-14-7-13(9-18-10-14)12-5-6-24-11-12/h3-11,19H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409854
PNG
(US10370333, Example IV-25)
Show SMILES COc1ccc(Br)cc1S(=O)(=O)Nc1cncc(c1)C(=O)N1CCN(C)CC1
Show InChI InChI=1S/C18H21BrN4O4S/c1-22-5-7-23(8-6-22)18(24)13-9-15(12-20-11-13)21-28(25,26)17-10-14(19)3-4-16(17)27-2/h3-4,9-12,21H,5-8H2,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409882
PNG
(US10370333, Example IX-10)
Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)Nc1cnc2ccc(cc2c1)C(N)=O
Show InChI InChI=1S/C18H17N3O5S/c1-25-14-4-6-16(26-2)17(9-14)27(23,24)21-13-8-12-7-11(18(19)22)3-5-15(12)20-10-13/h3-10,21H,1-2H3,(H2,19,22)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409930
PNG
(US10370333, Example XII-5)
Show SMILES NC(=O)c1cncc(NS(=O)(=O)c2cc(Cl)ccc2OC(F)(F)F)c1
Show InChI InChI=1S/C13H9ClF3N3O4S/c14-8-1-2-10(24-13(15,16)17)11(4-8)25(22,23)20-9-3-7(12(18)21)5-19-6-9/h1-6,20H,(H2,18,21)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409937
PNG
(US10370333, Example XII-12)
Show SMILES FC(F)(F)Oc1ccc(Br)cc1S(=O)(=O)Nc1cncc(c1)C(=O)Oc1ccccc1
Show InChI InChI=1S/C19H12BrF3N2O5S/c20-13-6-7-16(30-19(21,22)23)17(9-13)31(27,28)25-14-8-12(10-24-11-14)18(26)29-15-4-2-1-3-5-15/h1-11,25H
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409939
PNG
(US10370333, Example XII-14)
Show SMILES CNC(=O)c1cncc(NS(=O)(=O)c2cc(Br)ccc2OC(F)(F)F)c1
Show InChI InChI=1S/C14H11BrF3N3O4S/c1-19-13(22)8-4-10(7-20-6-8)21-26(23,24)12-5-9(15)2-3-11(12)25-14(16,17)18/h2-7,21H,1H3,(H,19,22)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409945
PNG
(US10370333, Example XII-20)
Show SMILES CNC(=O)c1cncc(NS(=O)(=O)c2cc(OC(F)(F)F)ccc2OC)c1
Show InChI InChI=1S/C15H14F3N3O5S/c1-19-14(22)9-5-10(8-20-7-9)21-27(23,24)13-6-11(26-15(16,17)18)3-4-12(13)25-2/h3-8,21H,1-2H3,(H,19,22)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409779
PNG
(US10370333, Example II-2)
Show SMILES COc1ccc(cc1S(=O)(=O)Nc1cnc2ccccc2c1)C(F)(F)F
Show InChI InChI=1S/C17H13F3N2O3S/c1-25-15-7-6-12(17(18,19)20)9-16(15)26(23,24)22-13-8-11-4-2-3-5-14(11)21-10-13/h2-10,22H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409786
PNG
(US10370333, Example III-2)
Show SMILES COc1ccc(cc1)-c1cncc(NS(=O)(=O)c2cc(Br)ccc2OC)c1
Show InChI InChI=1S/C19H17BrN2O4S/c1-25-17-6-3-13(4-7-17)14-9-16(12-21-11-14)22-27(23,24)19-10-15(20)5-8-18(19)26-2/h3-12,22H,1-2H3
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n/an/a 550n/an/an/an/an/an/a



SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409813
PNG
(US10370333, Example III-30)
Show SMILES COC(=O)c1ccc(cc1)-c1cncc(NS(=O)(=O)c2cc(Cl)ccc2OC)c1
Show InChI InChI=1S/C20H17ClN2O5S/c1-27-18-8-7-16(21)10-19(18)29(25,26)23-17-9-15(11-22-12-17)13-3-5-14(6-4-13)20(24)28-2/h3-12,23H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409866
PNG
(US10370333, Example VI-1)
Show SMILES Clc1ncc(Br)cc1S(=O)(=O)Nc1cnc2ccccc2c1
Show InChI InChI=1S/C14H9BrClN3O2S/c15-10-6-13(14(16)18-7-10)22(20,21)19-11-5-9-3-1-2-4-12(9)17-8-11/h1-8,19H
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409878
PNG
(US10370333, Example IX-6)
Show SMILES COc1ccc(Br)cc1S(=O)(=O)Nc1cnc2ccc(cc2c1)C(N)=O
Show InChI InChI=1S/C17H14BrN3O4S/c1-25-15-5-3-12(18)8-16(15)26(23,24)21-13-7-11-6-10(17(19)22)2-4-14(11)20-9-13/h2-9,21H,1H3,(H2,19,22)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409883
PNG
(US10370333, Example IX-11)
Show SMILES CNC(=O)c1ccc2ncc(NS(=O)(=O)c3cc(OC)ccc3OC)cc2c1
Show InChI InChI=1S/C19H19N3O5S/c1-20-19(23)12-4-6-16-13(8-12)9-14(11-21-16)22-28(24,25)18-10-15(26-2)5-7-17(18)27-3/h4-11,22H,1-3H3,(H,20,23)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409903
PNG
(US10370333, Example XI-12)
Show SMILES FC(F)(F)Oc1ccc(Cl)cc1S(=O)(=O)Nc1cncc(c1)-c1ccco1
Show InChI InChI=1S/C16H10ClF3N2O4S/c17-11-3-4-14(26-16(18,19)20)15(7-11)27(23,24)22-12-6-10(8-21-9-12)13-2-1-5-25-13/h1-9,22H
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409924
PNG
(US10370333, Example XI-31)
Show SMILES Cn1cc(cn1)-c1cncc(NS(=O)(=O)c2cc(Br)ccc2OC(F)(F)F)c1
Show InChI InChI=1S/C16H12BrF3N4O3S/c1-24-9-11(7-22-24)10-4-13(8-21-6-10)23-28(25,26)15-5-12(17)2-3-14(15)27-16(18,19)20/h2-9,23H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409929
PNG
(US10370333, Example XII-4)
Show SMILES FC(F)(F)Oc1ccc(Cl)cc1S(=O)(=O)Nc1cncc(c1)C(=O)Oc1ccccc1
Show InChI InChI=1S/C19H12ClF3N2O5S/c20-13-6-7-16(30-19(21,22)23)17(9-13)31(27,28)25-14-8-12(10-24-11-14)18(26)29-15-4-2-1-3-5-15/h1-11,25H
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409776
PNG
(US10370333, Example I-7)
Show SMILES COc1ccc(cc1S(=O)(=O)Nc1cccnc1)-c1ccccc1
Show InChI InChI=1S/C18H16N2O3S/c1-23-17-10-9-15(14-6-3-2-4-7-14)12-18(17)24(21,22)20-16-8-5-11-19-13-16/h2-13,20H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409777
PNG
(US10370333, Example I-14)
Show SMILES COC(=O)c1ccc(OC)c(c1)S(=O)(=O)Nc1cccnc1
Show InChI InChI=1S/C14H14N2O5S/c1-20-12-6-5-10(14(17)21-2)8-13(12)22(18,19)16-11-4-3-7-15-9-11/h3-9,16H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM46005
PNG
(4-methoxy-3-(3-quinolinylsulfamoyl)benzoic acid me...)
Show SMILES COC(=O)c1ccc(OC)c(c1)S(=O)(=O)Nc1cnc2ccccc2c1
Show InChI InChI=1S/C18H16N2O5S/c1-24-16-8-7-13(18(21)25-2)10-17(16)26(22,23)20-14-9-12-5-3-4-6-15(12)19-11-14/h3-11,20H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409785
PNG
(US10370333, Example III-1)
Show SMILES COc1ccc(cc1)-c1cncc(NS(=O)(=O)c2cc(OC)ccc2OC)c1
Show InChI InChI=1S/C20H20N2O5S/c1-25-17-6-4-14(5-7-17)15-10-16(13-21-12-15)22-28(23,24)20-11-18(26-2)8-9-19(20)27-3/h4-13,22H,1-3H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409788
PNG
(US10370333, Example III-3 | US10370333, Example XI...)
Show SMILES COc1ccc(cc1)-c1cncc(NS(=O)(=O)c2cc(Cl)ccc2OC)c1
Show InChI InChI=1S/C19H17ClN2O4S/c1-25-17-6-3-13(4-7-17)14-9-16(12-21-11-14)22-27(23,24)19-10-15(20)5-8-18(19)26-2/h3-12,22H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409815
PNG
(US10370333, Example III-33 | US10370333, Example X...)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cncc(c1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C19H14ClN3O3S/c1-26-18-7-6-16(20)9-19(18)27(24,25)23-17-8-15(11-22-12-17)14-4-2-13(10-21)3-5-14/h2-9,11-12,23H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409822
PNG
(US10370333, Example III-71)
Show SMILES COc1ccc(Br)cc1S(=O)(=O)Nc1cncc(c1)-c1ccoc1
Show InChI InChI=1S/C16H13BrN2O4S/c1-22-15-3-2-13(17)7-16(15)24(20,21)19-14-6-12(8-18-9-14)11-4-5-23-10-11/h2-10,19H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409832
PNG
(US10370333, Example III-93)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cncc(c1)-c1ncccn1
Show InChI InChI=1S/C16H13ClN4O3S/c1-24-14-4-3-12(17)8-15(14)25(22,23)21-13-7-11(9-18-10-13)16-19-5-2-6-20-16/h2-10,21H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409851
PNG
(US10370333, Example IV-24)
Show SMILES COc1ccc(Br)cc1S(=O)(=O)Nc1cncc(c1)C(=O)N1CCOCC1
Show InChI InChI=1S/C17H18BrN3O5S/c1-25-15-3-2-13(18)9-16(15)27(23,24)20-14-8-12(10-19-11-14)17(22)21-4-6-26-7-5-21/h2-3,8-11,20H,4-7H2,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409885
PNG
(US10370333, Example IX-13)
Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)Nc1cnc2ccc(cc2c1)C(=O)NC1CC1
Show InChI InChI=1S/C21H21N3O5S/c1-28-17-6-8-19(29-2)20(11-17)30(26,27)24-16-10-14-9-13(3-7-18(14)22-12-16)21(25)23-15-4-5-15/h3,6-12,15,24H,4-5H2,1-2H3,(H,23,25)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409923
PNG
(US10370333, Example XI-30)
Show SMILES COc1ccc(OC(F)(F)F)cc1S(=O)(=O)Nc1cncc(c1)-c1cscn1
Show InChI InChI=1S/C16H12F3N3O4S2/c1-25-14-3-2-12(26-16(17,18)19)5-15(14)28(23,24)22-11-4-10(6-20-7-11)13-8-27-9-21-13/h2-9,22H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409940
PNG
(US10370333, Example XII-15)
Show SMILES COC(=O)c1cncc(NS(=O)(=O)c2cc(OC(F)(F)F)ccc2OC)c1
Show InChI InChI=1S/C15H13F3N2O6S/c1-24-12-4-3-11(26-15(16,17)18)6-13(12)27(22,23)20-10-5-9(7-19-8-10)14(21)25-2/h3-8,20H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409839
PNG
(US10370333, Example IV-8)
Show SMILES CCCOC(=O)c1cncc(NS(=O)(=O)c2cc(Cl)ccc2OC)c1
Show InChI InChI=1S/C16H17ClN2O5S/c1-3-6-24-16(20)11-7-13(10-18-9-11)19-25(21,22)15-8-12(17)4-5-14(15)23-2/h4-5,7-10,19H,3,6H2,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409867
PNG
(US10370333, Example VI-2)
Show SMILES COc1ncc(cc1S(=O)(=O)Nc1cnc2ccccc2c1)B1OC(C)(C)C(C)(C)O1
Show InChI InChI=1S/C21H24BN3O5S/c1-20(2)21(3,4)30-22(29-20)15-11-18(19(28-5)24-12-15)31(26,27)25-16-10-14-8-6-7-9-17(14)23-13-16/h6-13,25H,1-5H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409877
PNG
(US10370333, Example IX-5)
Show SMILES COc1ccc(Br)cc1S(=O)(=O)Nc1cnc2ccc(cc2c1)C(O)=O
Show InChI InChI=1S/C17H13BrN2O5S/c1-25-15-5-3-12(18)8-16(15)26(23,24)20-13-7-11-6-10(17(21)22)2-4-14(11)19-9-13/h2-9,20H,1H3,(H,21,22)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409922
PNG
(US10370333, Example XI-29)
Show SMILES FC(F)(F)Oc1ccc(Br)cc1S(=O)(=O)Nc1cncc(c1)-c1cscn1
Show InChI InChI=1S/C15H9BrF3N3O3S2/c16-10-1-2-13(25-15(17,18)19)14(4-10)27(23,24)22-11-3-9(5-20-6-11)12-7-26-8-21-12/h1-8,22H
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409931
PNG
(US10370333, Example XII-6)
Show SMILES CNC(=O)c1cncc(NS(=O)(=O)c2cc(Cl)ccc2OC(F)(F)F)c1
Show InChI InChI=1S/C14H11ClF3N3O4S/c1-19-13(22)8-4-10(7-20-6-8)21-26(23,24)12-5-9(15)2-3-11(12)25-14(16,17)18/h2-7,21H,1H3,(H,19,22)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409816
PNG
(US10370333, Example III-37)
Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)Nc1cncc(c1)-c1ccccc1C
Show InChI InChI=1S/C20H20N2O4S/c1-14-6-4-5-7-18(14)15-10-16(13-21-12-15)22-27(23,24)20-11-17(25-2)8-9-19(20)26-3/h4-13,22H,1-3H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409831
PNG
(US10370333, Example III-92)
Show SMILES COc1ccc(Br)cc1S(=O)(=O)Nc1cncc(c1)-c1ncccn1
Show InChI InChI=1S/C16H13BrN4O3S/c1-24-14-4-3-12(17)8-15(14)25(22,23)21-13-7-11(9-18-10-13)16-19-5-2-6-20-16/h2-10,21H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409835
PNG
(US10370333, Example IV-3)
Show SMILES CCCOC(=O)c1cncc(NS(=O)(=O)c2cc(Br)ccc2OC)c1
Show InChI InChI=1S/C16H17BrN2O5S/c1-3-6-24-16(20)11-7-13(10-18-9-11)19-25(21,22)15-8-12(17)4-5-14(15)23-2/h4-5,7-10,19H,3,6H2,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409856
PNG
(US10370333, Example IV-43)
Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)Nc1cncc(c1)C(=O)N1CCOCC1
Show InChI InChI=1S/C18H21N3O6S/c1-25-15-3-4-16(26-2)17(10-15)28(23,24)20-14-9-13(11-19-12-14)18(22)21-5-7-27-8-6-21/h3-4,9-12,20H,5-8H2,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409904
PNG
(US10370333, Example XI-13)
Show SMILES COc1ccc(OC(F)(F)F)cc1S(=O)(=O)Nc1cncc(c1)-c1ccco1
Show InChI InChI=1S/C17H13F3N2O5S/c1-25-15-5-4-13(27-17(18,19)20)8-16(15)28(23,24)22-12-7-11(9-21-10-12)14-3-2-6-26-14/h2-10,22H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409925
PNG
(US10370333, Example XI-32)
Show SMILES COc1ccc(OC(F)(F)F)cc1S(=O)(=O)Nc1cncc(c1)-c1cnn(C)c1
Show InChI InChI=1S/C17H15F3N4O4S/c1-24-10-12(8-22-24)11-5-13(9-21-7-11)23-29(25,26)16-6-14(28-17(18,19)20)3-4-15(16)27-2/h3-10,23H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409934
PNG
(US10370333, Example XII-9)
Show SMILES COC(=O)c1cncc(NS(=O)(=O)c2cc(Br)ccc2OC(F)(F)F)c1
Show InChI InChI=1S/C14H10BrF3N2O5S/c1-24-13(21)8-4-10(7-19-6-8)20-26(22,23)12-5-9(15)2-3-11(12)25-14(16,17)18/h2-7,20H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409943
PNG
(US10370333, Example XII-18)
Show SMILES COc1ccc(OC(F)(F)F)cc1S(=O)(=O)Nc1cncc(c1)C(=O)Oc1ccccc1
Show InChI InChI=1S/C20H15F3N2O6S/c1-29-17-8-7-16(31-20(21,22)23)10-18(17)32(27,28)25-14-9-13(11-24-12-14)19(26)30-15-5-3-2-4-6-15/h2-12,25H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409946
PNG
(US10370333, Example XII-21)
Show SMILES CCCNC(=O)c1cncc(NS(=O)(=O)c2cc(OC(F)(F)F)ccc2OC)c1
Show InChI InChI=1S/C17H18F3N3O5S/c1-3-6-22-16(24)11-7-12(10-21-9-11)23-29(25,26)15-8-13(28-17(18,19)20)4-5-14(15)27-2/h4-5,7-10,23H,3,6H2,1-2H3,(H,22,24)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409957
PNG
(US10370333, Example XIII-9)
Show SMILES COc1ccc(cn1)-c1cncc(NS(=O)(=O)c2cc(Cl)ccc2OC)c1
Show InChI InChI=1S/C18H16ClN3O4S/c1-25-16-5-4-14(19)8-17(16)27(23,24)22-15-7-13(9-20-11-15)12-3-6-18(26-2)21-10-12/h3-11,22H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409959
PNG
(US10370333, Example XIII-11)
Show SMILES COc1ccc(cc1)-c1cncc(NS(=O)(=O)c2cc(F)ccc2OC)c1
Show InChI InChI=1S/C19H17FN2O4S/c1-25-17-6-3-13(4-7-17)14-9-16(12-21-11-14)22-27(23,24)19-10-15(20)5-8-18(19)26-2/h3-12,22H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409780
PNG
(US10370333, Example II-3)
Show SMILES COc1cc(C)ccc1S(=O)(=O)Nc1cnc2ccccc2c1
Show InChI InChI=1S/C17H16N2O3S/c1-12-7-8-17(16(9-12)22-2)23(20,21)19-14-10-13-5-3-4-6-15(13)18-11-14/h3-11,19H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409935
PNG
(US10370333, Example XII-10)
Show SMILES OC(=O)c1cncc(NS(=O)(=O)c2cc(Br)ccc2OC(F)(F)F)c1
Show InChI InChI=1S/C13H8BrF3N2O5S/c14-8-1-2-10(24-13(15,16)17)11(4-8)25(22,23)19-9-3-7(12(20)21)5-18-6-9/h1-6,19H,(H,20,21)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409891
PNG
(US10370333, Example XI-1)
Show SMILES COc1ccc(cc1)-c1cncc(NS(=O)(=O)c2cc(Cl)ccc2OC(F)(F)F)c1
Show InChI InChI=1S/C19H14ClF3N2O4S/c1-28-16-5-2-12(3-6-16)13-8-15(11-24-10-13)25-30(26,27)18-9-14(20)4-7-17(18)29-19(21,22)23/h2-11,25H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409900
PNG
(US10370333, Example XI-9)
Show SMILES Fc1ccc(cc1)-c1cncc(NS(=O)(=O)c2cc(Br)ccc2OC(F)(F)F)c1
Show InChI InChI=1S/C18H11BrF4N2O3S/c19-13-3-6-16(28-18(21,22)23)17(8-13)29(26,27)25-15-7-12(9-24-10-15)11-1-4-14(20)5-2-11/h1-10,25H
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409941
PNG
(US10370333, Example XII-16)
Show SMILES CCCOC(=O)c1cncc(NS(=O)(=O)c2cc(OC(F)(F)F)ccc2OC)c1
Show InChI InChI=1S/C17H17F3N2O6S/c1-3-6-27-16(23)11-7-12(10-21-9-11)22-29(24,25)15-8-13(28-17(18,19)20)4-5-14(15)26-2/h4-5,7-10,22H,3,6H2,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409794
PNG
(US10370333, Example III-11)
Show SMILES COc1ccc(Br)cc1S(=O)(=O)Nc1cncc(c1)-c1ccc(C)cc1
Show InChI InChI=1S/C19H17BrN2O3S/c1-13-3-5-14(6-4-13)15-9-17(12-21-11-15)22-26(23,24)19-10-16(20)7-8-18(19)25-2/h3-12,22H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409802
PNG
(US10370333, Example III-16)
Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)Nc1cncc(c1)-c1ccc(F)cc1
Show InChI InChI=1S/C19H17FN2O4S/c1-25-17-7-8-18(26-2)19(10-17)27(23,24)22-16-9-14(11-21-12-16)13-3-5-15(20)6-4-13/h3-12,22H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409871
PNG
(US10370333, Example VIII-16)
Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)Nc1ccc(Nc2ccccc2)nc1
Show InChI InChI=1S/C19H19N3O4S/c1-25-16-9-10-17(26-2)18(12-16)27(23,24)22-15-8-11-19(20-13-15)21-14-6-4-3-5-7-14/h3-13,22H,1-2H3,(H,20,21)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409907
PNG
(US10370333, Example XI-16)
Show SMILES COc1ccc(OC(F)(F)F)cc1S(=O)(=O)Nc1cncc(c1)-c1cccs1
Show InChI InChI=1S/C17H13F3N2O4S2/c1-25-14-5-4-13(26-17(18,19)20)8-16(14)28(23,24)22-12-7-11(9-21-10-12)15-3-2-6-27-15/h2-10,22H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409920
PNG
(US10370333, Example XI-27)
Show SMILES COc1ccc(OC(F)(F)F)cc1S(=O)(=O)Nc1cncc(c1)-c1cncs1
Show InChI InChI=1S/C16H12F3N3O4S2/c1-25-13-3-2-12(26-16(17,18)19)5-15(13)28(23,24)22-11-4-10(6-20-7-11)14-8-21-9-27-14/h2-9,22H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409793
PNG
(US10370333, Example III-10)
Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)Nc1cncc(c1)-c1ccc(C)cc1
Show InChI InChI=1S/C20H20N2O4S/c1-14-4-6-15(7-5-14)16-10-17(13-21-12-16)22-27(23,24)20-11-18(25-2)8-9-19(20)26-3/h4-13,22H,1-3H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409797
PNG
(US10370333, Example III-13)
Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)Nc1cncc(c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C20H17F3N2O4S/c1-28-17-7-8-18(29-2)19(10-17)30(26,27)25-16-9-14(11-24-12-16)13-3-5-15(6-4-13)20(21,22)23/h3-12,25H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409806
PNG
(US10370333, Example III-20)
Show SMILES COc1ccc(Br)cc1S(=O)(=O)Nc1cncc(c1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C18H14BrClN2O3S/c1-25-17-7-4-14(19)9-18(17)26(23,24)22-16-8-13(10-21-11-16)12-2-5-15(20)6-3-12/h2-11,22H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409807
PNG
(US10370333, Example III-21)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cncc(c1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C18H14Cl2N2O3S/c1-25-17-7-6-15(20)9-18(17)26(23,24)22-16-8-13(10-21-11-16)12-2-4-14(19)5-3-12/h2-11,22H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409818
PNG
(US10370333, Example III-39)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cncc(c1)-c1ccccc1C
Show InChI InChI=1S/C19H17ClN2O3S/c1-13-5-3-4-6-17(13)14-9-16(12-21-11-14)22-26(23,24)19-10-15(20)7-8-18(19)25-2/h3-12,22H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409850
PNG
(US10370333, Example IV-23)
Show SMILES COc1ccc(Br)cc1S(=O)(=O)Nc1cncc(c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C19H16BrN3O4S/c1-27-17-8-7-14(20)10-18(17)28(25,26)23-16-9-13(11-21-12-16)19(24)22-15-5-3-2-4-6-15/h2-12,23H,1H3,(H,22,24)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409859
PNG
(US10370333, Example V-3)
Show SMILES COc1ccc(Br)cc1S(=O)(=O)Nc1ncco1
Show InChI InChI=1S/C10H9BrN2O4S/c1-16-8-3-2-7(11)6-9(8)18(14,15)13-10-12-4-5-17-10/h2-6H,1H3,(H,12,13)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409860
PNG
(US10370333, Example V-7)
Show SMILES COc1ccc(Br)cc1S(=O)(=O)Nc1ccn(n1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C15H18BrN3O5S/c1-15(2,3)24-14(20)19-8-7-13(17-19)18-25(21,22)12-9-10(16)5-6-11(12)23-4/h5-9H,1-4H3,(H,17,18)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409862
PNG
(US10370333, Example V-19)
Show SMILES COc1ccc(Br)cc1S(=O)(=O)Nc1nnc(s1)C(F)(F)F
Show InChI InChI=1S/C10H7BrF3N3O3S2/c1-20-6-3-2-5(11)4-7(6)22(18,19)17-9-16-15-8(21-9)10(12,13)14/h2-4H,1H3,(H,16,17)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409876
PNG
(US10370333, Example IX-4)
Show SMILES COC(=O)c1ccc2ncc(NS(=O)(=O)c3cc(Br)ccc3OC)cc2c1
Show InChI InChI=1S/C18H15BrN2O5S/c1-25-16-6-4-13(19)9-17(16)27(23,24)21-14-8-12-7-11(18(22)26-2)3-5-15(12)20-10-14/h3-10,21H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409889
PNG
(US10370333, Example X-3)
Show SMILES FC(F)(F)Oc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2ccccc2c1
Show InChI InChI=1S/C16H10ClF3N2O3S/c17-11-5-6-14(25-16(18,19)20)15(8-11)26(23,24)22-12-7-10-3-1-2-4-13(10)21-9-12/h1-9,22H
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409901
PNG
(US10370333, Example XI-10)
Show SMILES COc1ccc(OC(F)(F)F)cc1S(=O)(=O)Nc1cncc(c1)-c1ccc(F)cc1
Show InChI InChI=1S/C19H14F4N2O4S/c1-28-17-7-6-16(29-19(21,22)23)9-18(17)30(26,27)25-15-8-13(10-24-11-15)12-2-4-14(20)5-3-12/h2-11,25H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409910
PNG
(US10370333, Example XI-19)
Show SMILES COc1ccc(OC(F)(F)F)cc1S(=O)(=O)Nc1cncc(c1)-c1ccccn1
Show InChI InChI=1S/C18H14F3N3O4S/c1-27-16-6-5-14(28-18(19,20)21)9-17(16)29(25,26)24-13-8-12(10-22-11-13)15-4-2-3-7-23-15/h2-11,24H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409915
PNG
(US10370333, Example XI-22)
Show SMILES COc1ccc(OC(F)(F)F)cc1S(=O)(=O)Nc1cncc(c1)-c1cnccn1
Show InChI InChI=1S/C17H13F3N4O4S/c1-27-15-3-2-13(28-17(18,19)20)7-16(15)29(25,26)24-12-6-11(8-22-9-12)14-10-21-4-5-23-14/h2-10,24H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409812
PNG
(US10370333, Example III-29)
Show SMILES COC(=O)c1ccc(cc1)-c1cncc(NS(=O)(=O)c2cc(Br)ccc2OC)c1
Show InChI InChI=1S/C20H17BrN2O5S/c1-27-18-8-7-16(21)10-19(18)29(25,26)23-17-9-15(11-22-12-17)13-3-5-14(6-4-13)20(24)28-2/h3-12,23H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409826
PNG
(US10370333, Example III-77)
Show SMILES COc1ccc(Br)cc1S(=O)(=O)Nc1cncc(c1)-c1ccsc1
Show InChI InChI=1S/C16H13BrN2O3S2/c1-22-15-3-2-13(17)7-16(15)24(20,21)19-14-6-12(8-18-9-14)11-4-5-23-10-11/h2-10,19H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409868
PNG
(US10370333, Example VIII-3)
Show SMILES COc1ccc(Br)cc1S(=O)(=O)Nc1ccc(nc1)[N+]([O-])=O
Show InChI InChI=1S/C12H10BrN3O5S/c1-21-10-4-2-8(13)6-11(10)22(19,20)15-9-3-5-12(14-7-9)16(17)18/h2-7,15H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409896
PNG
(US10370333, Example XI-6)
Show SMILES COc1ccc(c(OC)c1)-c1cncc(NS(=O)(=O)c2cc(Br)ccc2OC(F)(F)F)c1
Show InChI InChI=1S/C20H16BrF3N2O5S/c1-29-15-4-5-16(18(9-15)30-2)12-7-14(11-25-10-12)26-32(27,28)19-8-13(21)3-6-17(19)31-20(22,23)24/h3-11,26H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409899
PNG
(US10370333, Example XI-8)
Show SMILES Fc1ccc(cc1)-c1cncc(NS(=O)(=O)c2cc(Cl)ccc2OC(F)(F)F)c1
Show InChI InChI=1S/C18H11ClF4N2O3S/c19-13-3-6-16(28-18(21,22)23)17(8-13)29(26,27)25-15-7-12(9-24-10-15)11-1-4-14(20)5-2-11/h1-10,25H
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409905
PNG
(US10370333, Example XI-14)
Show SMILES FC(F)(F)Oc1ccc(Cl)cc1S(=O)(=O)Nc1cncc(c1)-c1cccs1
Show InChI InChI=1S/C16H10ClF3N2O3S2/c17-11-3-4-13(25-16(18,19)20)15(7-11)27(23,24)22-12-6-10(8-21-9-12)14-2-1-5-26-14/h1-9,22H
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409913
PNG
(US10370333, Example XI-20)
Show SMILES FC(F)(F)Oc1ccc(Cl)cc1S(=O)(=O)Nc1cncc(c1)-c1cnccn1
Show InChI InChI=1S/C16H10ClF3N4O3S/c17-11-1-2-14(27-16(18,19)20)15(6-11)28(25,26)24-12-5-10(7-22-8-12)13-9-21-3-4-23-13/h1-9,24H
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409917
PNG
(US10370333, Example XI-24)
Show SMILES FC(F)(F)Oc1ccc(Br)cc1S(=O)(=O)Nc1cncc(c1)-c1ncccn1
Show InChI InChI=1S/C16H10BrF3N4O3S/c17-11-2-3-13(27-16(18,19)20)14(7-11)28(25,26)24-12-6-10(8-21-9-12)15-22-4-1-5-23-15/h1-9,24H
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409796
PNG
(US10370333, Example III-12)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cncc(c1)-c1ccc(C)cc1
Show InChI InChI=1S/C19H17ClN2O3S/c1-13-3-5-14(6-4-13)15-9-17(12-21-11-15)22-26(23,24)19-10-16(20)7-8-18(19)25-2/h3-12,22H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409808
PNG
(US10370333, Example III-22)
Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)Nc1cncc(c1)-c1ccc(Br)cc1
Show InChI InChI=1S/C19H17BrN2O4S/c1-25-17-7-8-18(26-2)19(10-17)27(23,24)22-16-9-14(11-21-12-16)13-3-5-15(20)6-4-13/h3-12,22H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409810
PNG
(US10370333, Example III-24)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cncc(c1)-c1ccc(Br)cc1
Show InChI InChI=1S/C18H14BrClN2O3S/c1-25-17-7-6-15(20)9-18(17)26(23,24)22-16-8-13(10-21-11-16)12-2-4-14(19)5-3-12/h2-11,22H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409864
PNG
(US10370333, Example V-23)
Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)Nc1cnccn1
Show InChI InChI=1S/C12H13N3O4S/c1-18-9-3-4-10(19-2)11(7-9)20(16,17)15-12-8-13-5-6-14-12/h3-8H,1-2H3,(H,14,15)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409892
PNG
(US10370333, Example XI-2)
Show SMILES COc1ccc(cc1)-c1cncc(NS(=O)(=O)c2cc(OC(F)(F)F)ccc2OC)c1
Show InChI InChI=1S/C20H17F3N2O5S/c1-28-16-5-3-13(4-6-16)14-9-15(12-24-11-14)25-31(26,27)19-10-17(30-20(21,22)23)7-8-18(19)29-2/h3-12,25H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409893
PNG
(US10370333, Example XI-3)
Show SMILES FC(F)(F)Oc1ccc(cc1)-c1cncc(NS(=O)(=O)c2cc(Cl)ccc2OC(F)(F)F)c1
Show InChI InChI=1S/C19H11ClF6N2O4S/c20-13-3-6-16(32-19(24,25)26)17(8-13)33(29,30)28-14-7-12(9-27-10-14)11-1-4-15(5-2-11)31-18(21,22)23/h1-10,28H
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409906
PNG
(US10370333, Example XI-15)
Show SMILES FC(F)(F)Oc1ccc(Br)cc1S(=O)(=O)Nc1cncc(c1)-c1cccs1
Show InChI InChI=1S/C16H10BrF3N2O3S2/c17-11-3-4-13(25-16(18,19)20)15(7-11)27(23,24)22-12-6-10(8-21-9-12)14-2-1-5-26-14/h1-9,22H
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409909
PNG
(US10370333, Example XI-18)
Show SMILES FC(F)(F)Oc1ccc(Br)cc1S(=O)(=O)Nc1cncc(c1)-c1ccccn1
Show InChI InChI=1S/C17H11BrF3N3O3S/c18-12-4-5-15(27-17(19,20)21)16(8-12)28(25,26)24-13-7-11(9-22-10-13)14-3-1-2-6-23-14/h1-10,24H
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409914
PNG
(US10370333, Example XI-21)
Show SMILES FC(F)(F)Oc1ccc(Br)cc1S(=O)(=O)Nc1cncc(c1)-c1cnccn1
Show InChI InChI=1S/C16H10BrF3N4O3S/c17-11-1-2-14(27-16(18,19)20)15(6-11)28(25,26)24-12-5-10(7-22-8-12)13-9-21-3-4-23-13/h1-9,24H
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409933
PNG
(US10370333, Example XII-8)
Show SMILES FC(F)(F)Oc1ccc(Cl)cc1S(=O)(=O)Nc1cncc(c1)C(=O)NC1CCCCC1
Show InChI InChI=1S/C19H19ClF3N3O4S/c20-13-6-7-16(30-19(21,22)23)17(9-13)31(28,29)26-15-8-12(10-24-11-15)18(27)25-14-4-2-1-3-5-14/h6-11,14,26H,1-5H2,(H,25,27)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409881
PNG
(US10370333, Example IX-9)
Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)Nc1cnc2ccc(cc2c1)C(O)=O
Show InChI InChI=1S/C18H16N2O6S/c1-25-14-4-6-16(26-2)17(9-14)27(23,24)20-13-8-12-7-11(18(21)22)3-5-15(12)19-10-13/h3-10,20H,1-2H3,(H,21,22)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409908
PNG
(US10370333, Example XI-17)
Show SMILES FC(F)(F)Oc1ccc(Cl)cc1S(=O)(=O)Nc1cncc(c1)-c1ccccn1
Show InChI InChI=1S/C17H11ClF3N3O3S/c18-12-4-5-15(27-17(19,20)21)16(8-12)28(25,26)24-13-7-11(9-22-10-13)14-3-1-2-6-23-14/h1-10,24H
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409948
PNG
(US10370333, Example XII-23)
Show SMILES COC(=O)c1cncc(NS(=O)(=O)c2cc(OC)ccc2OC(F)(F)F)c1
Show InChI InChI=1S/C15H13F3N2O6S/c1-24-11-3-4-12(26-15(16,17)18)13(6-11)27(22,23)20-10-5-9(7-19-8-10)14(21)25-2/h3-8,20H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM45900
PNG
(2,4-dimethoxy-N-(3-quinolinyl)benzenesulfonamide |...)
Show SMILES COc1ccc(c(OC)c1)S(=O)(=O)Nc1cnc2ccccc2c1
Show InChI InChI=1S/C17H16N2O4S/c1-22-14-7-8-17(16(10-14)23-2)24(20,21)19-13-9-12-5-3-4-6-15(12)18-11-13/h3-11,19H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409799
PNG
(US10370333, Example III-14)
Show SMILES COc1ccc(Br)cc1S(=O)(=O)Nc1cncc(c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C19H14BrF3N2O3S/c1-28-17-7-6-15(20)9-18(17)29(26,27)25-16-8-13(10-24-11-16)12-2-4-14(5-3-12)19(21,22)23/h2-11,25H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409804
PNG
(US10370333, Example III-18)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cncc(c1)-c1ccc(F)cc1
Show InChI InChI=1S/C18H14ClFN2O3S/c1-25-17-7-4-14(19)9-18(17)26(23,24)22-16-8-13(10-21-11-16)12-2-5-15(20)6-3-12/h2-11,22H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409817
PNG
(US10370333, Example III-38)
Show SMILES COc1ccc(Br)cc1S(=O)(=O)Nc1cncc(c1)-c1ccccc1C
Show InChI InChI=1S/C19H17BrN2O3S/c1-13-5-3-4-6-17(13)14-9-16(12-21-11-14)22-26(23,24)19-10-15(20)7-8-18(19)25-2/h3-12,22H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409827
PNG
(US10370333, Example III-78)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cncc(c1)-c1ccsc1
Show InChI InChI=1S/C16H13ClN2O3S2/c1-22-15-3-2-13(17)7-16(15)24(20,21)19-14-6-12(8-18-9-14)11-4-5-23-10-11/h2-10,19H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409863
PNG
(US10370333, Example V-20)
Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)Nc1nnc(s1)C(F)(F)F
Show InChI InChI=1S/C11H10F3N3O4S2/c1-20-6-3-4-7(21-2)8(5-6)23(18,19)17-10-16-15-9(22-10)11(12,13)14/h3-5H,1-2H3,(H,16,17)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409894
PNG
(US10370333, Example XI-4)
Show SMILES FC(F)(F)Oc1ccc(cc1)-c1cncc(NS(=O)(=O)c2cc(Br)ccc2OC(F)(F)F)c1
Show InChI InChI=1S/C19H11BrF6N2O4S/c20-13-3-6-16(32-19(24,25)26)17(8-13)33(29,30)28-14-7-12(9-27-10-14)11-1-4-15(5-2-11)31-18(21,22)23/h1-10,28H
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409895
PNG
(US10370333, Example XI-5)
Show SMILES COc1ccc(c(OC)c1)-c1cncc(NS(=O)(=O)c2cc(Cl)ccc2OC(F)(F)F)c1
Show InChI InChI=1S/C20H16ClF3N2O5S/c1-29-15-4-5-16(18(9-15)30-2)12-7-14(11-25-10-12)26-32(27,28)19-8-13(21)3-6-17(19)31-20(22,23)24/h3-11,26H,1-2H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409902
PNG
(US10370333, Example XI-11)
Show SMILES FC(F)(F)Oc1ccc(Br)cc1S(=O)(=O)Nc1cncc(c1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C19H11BrF3N3O3S/c20-15-5-6-17(29-19(21,22)23)18(8-15)30(27,28)26-16-7-14(10-25-11-16)13-3-1-12(9-24)2-4-13/h1-8,10-11,26H
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409928
PNG
(US10370333, Example XII-3)
Show SMILES FC(F)(F)Oc1ccc(Cl)cc1S(=O)(=O)Nc1cncc(c1)C(=O)OC1CCCCC1
Show InChI InChI=1S/C19H18ClF3N2O5S/c20-13-6-7-16(30-19(21,22)23)17(9-13)31(27,28)25-14-8-12(10-24-11-14)18(26)29-15-4-2-1-3-5-15/h6-11,15,25H,1-5H2
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409870
PNG
(US10370333, Example VIII-15)
Show SMILES COc1ccc(Br)cc1S(=O)(=O)Nc1ccc(Nc2ccccc2)nc1
Show InChI InChI=1S/C18H16BrN3O3S/c1-25-16-9-7-13(19)11-17(16)26(23,24)22-15-8-10-18(20-12-15)21-14-5-3-2-4-6-14/h2-12,22H,1H3,(H,20,21)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409880
PNG
(US10370333, Example IX-8)
Show SMILES COC(=O)c1ccc2ncc(NS(=O)(=O)c3cc(OC)ccc3OC)cc2c1
Show InChI InChI=1S/C19H18N2O6S/c1-25-15-5-7-17(26-2)18(10-15)28(23,24)21-14-9-13-8-12(19(22)27-3)4-6-16(13)20-11-14/h4-11,21H,1-3H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409897
PNG
(US10370333, Example XI-7)
Show SMILES COc1ccc(c(OC)c1)-c1cncc(NS(=O)(=O)c2cc(OC(F)(F)F)ccc2OC)c1
Show InChI InChI=1S/C21H19F3N2O6S/c1-29-15-4-6-17(19(9-15)31-3)13-8-14(12-25-11-13)26-33(27,28)20-10-16(32-21(22,23)24)5-7-18(20)30-2/h4-12,26H,1-3H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409916
PNG
(US10370333, Example XI-23)
Show SMILES FC(F)(F)Oc1ccc(Cl)cc1S(=O)(=O)Nc1cncc(c1)-c1ncccn1
Show InChI InChI=1S/C16H10ClF3N4O3S/c17-11-2-3-13(27-16(18,19)20)14(7-11)28(25,26)24-12-6-10(8-21-9-12)15-22-4-1-5-23-15/h1-9,24H
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409918
PNG
(US10370333, Example XI-25)
Show SMILES FC(F)(F)Oc1ccc(Cl)cc1S(=O)(=O)Nc1cncc(c1)-c1cncs1
Show InChI InChI=1S/C15H9ClF3N3O3S2/c16-10-1-2-12(25-15(17,18)19)14(4-10)27(23,24)22-11-3-9(5-20-6-11)13-7-21-8-26-13/h1-8,22H
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409919
PNG
(US10370333, Example XI-26)
Show SMILES FC(F)(F)Oc1ccc(Br)cc1S(=O)(=O)Nc1cncc(c1)-c1cncs1
Show InChI InChI=1S/C15H9BrF3N3O3S2/c16-10-1-2-12(25-15(17,18)19)14(4-10)27(23,24)22-11-3-9(5-20-6-11)13-7-21-8-26-13/h1-8,22H
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409932
PNG
(US10370333, Example XII-7)
Show SMILES CCCNC(=O)c1cncc(NS(=O)(=O)c2cc(Cl)ccc2OC(F)(F)F)c1
Show InChI InChI=1S/C16H15ClF3N3O4S/c1-2-5-22-15(24)10-6-12(9-21-8-10)23-28(25,26)14-7-11(17)3-4-13(14)27-16(18,19)20/h3-4,6-9,23H,2,5H2,1H3,(H,22,24)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409936
PNG
(US10370333, Example XII-11)
Show SMILES FC(F)(F)Oc1ccc(Br)cc1S(=O)(=O)Nc1cncc(c1)C(=O)OC1CCCCC1
Show InChI InChI=1S/C19H18BrF3N2O5S/c20-13-6-7-16(30-19(21,22)23)17(9-13)31(27,28)25-14-8-12(10-24-11-14)18(26)29-15-4-2-1-3-5-15/h6-11,15,25H,1-5H2
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409942
PNG
(US10370333, Example XII-17)
Show SMILES COc1ccc(OC(F)(F)F)cc1S(=O)(=O)Nc1cncc(c1)C(=O)OC1CCCCC1
Show InChI InChI=1S/C20H21F3N2O6S/c1-29-17-8-7-16(31-20(21,22)23)10-18(17)32(27,28)25-14-9-13(11-24-12-14)19(26)30-15-5-3-2-4-6-15/h7-12,15,25H,2-6H2,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409947
PNG
(US10370333, Example XII-22)
Show SMILES COc1ccc(OC(F)(F)F)cc1S(=O)(=O)Nc1cncc(c1)C(=O)NC1CCCCC1
Show InChI InChI=1S/C20H22F3N3O5S/c1-30-17-8-7-16(31-20(21,22)23)10-18(17)32(28,29)26-15-9-13(11-24-12-15)19(27)25-14-5-3-2-4-6-14/h7-12,14,26H,2-6H2,1H3,(H,25,27)
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409782
PNG
(US10370333, Example II-6)
Show SMILES COc1ccc(cc1S(=O)(=O)Nc1cnc2ccccc2c1)-c1ccccc1
Show InChI InChI=1S/C22H18N2O3S/c1-27-21-12-11-17(16-7-3-2-4-8-16)14-22(21)28(25,26)24-19-13-18-9-5-6-10-20(18)23-15-19/h2-15,24H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409801
PNG
(US10370333, Example III-15)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cncc(c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C19H14ClF3N2O3S/c1-28-17-7-6-15(20)9-18(17)29(26,27)25-16-8-13(10-24-11-16)12-2-4-14(5-3-12)19(21,22)23/h2-11,25H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409803
PNG
(US10370333, Example III-17)
Show SMILES COc1ccc(Br)cc1S(=O)(=O)Nc1cncc(c1)-c1ccc(F)cc1
Show InChI InChI=1S/C18H14BrFN2O3S/c1-25-17-7-4-14(19)9-18(17)26(23,24)22-16-8-13(10-21-11-16)12-2-5-15(20)6-3-12/h2-11,22H,1H3
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SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409805
PNG
(US10370333, Example III-19)
Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)Nc1cncc(c1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H17ClN2O4S/c1-25-17-7-8-18(26-2)19(10-17)27(23,24)22-16-9-14(11-21-12-16)13-3-5-15(20)6-4-13/h3-12,22H,1-2H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM409861
PNG
(US10370333, Example V-8)
Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)Nc1cc[nH]n1
Show InChI InChI=1S/C11H13N3O4S/c1-17-8-3-4-9(18-2)10(7-8)19(15,16)14-11-5-6-12-13-11/h3-7H,1-2H3,(H2,12,13,14)
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antibodypedia
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n/an/a>1.00E+3n/an/an/an/an/an/a



SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
To determine the inhibition selectivity for inhibitor candidates, human TNAP, PLAP or IAP were added to microtiter plates followed by addition of the...


US Patent US10370333 (2019)


BindingDB Entry DOI: 10.7270/Q2445PVM
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%