Affinity Data by Patent

Patent code US10370337

Found 5 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Phosphodiesterase (PDE9A2) (Homo sapiens (Human))	BDBM409965 (4-(cycloheptyl- oxy)-2-oxo-1,2- dihydro- quinoline...) Show SMILES O=c1[nH]c2ccccc2c(OC2CCCCCC2)c1C#N Show InChI	PDB UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem	US Patent	29	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck, Sharp & Dohme Corp. US Patent					Assay Description Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...				US Patent US10370337 (2019) BindingDB Entry DOI: 10.7270/Q2VM4FMJ
Merck, Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Phosphodiesterase (PDE9A2) (Homo sapiens (Human))	BDBM409964 (US10370337, Example 1-7) Show SMILES O=c1[nH]c2ccccc2c(OC2CCCCC2)c1C#N Show InChI	PDB UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem	US Patent	50.3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck, Sharp & Dohme Corp. US Patent					Assay Description Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...				US Patent US10370337 (2019) BindingDB Entry DOI: 10.7270/Q2VM4FMJ
Merck, Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Phosphodiesterase (PDE9A2) (Homo sapiens (Human))	BDBM409968 (4-((3-allyl- oxetan-3-yl) methoxy)-2- oxo-1,2- dih...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem	US Patent	87.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck, Sharp & Dohme Corp. US Patent					Assay Description Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...				US Patent US10370337 (2019) BindingDB Entry DOI: 10.7270/Q2VM4FMJ
Merck, Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Phosphodiesterase (PDE9A2) (Homo sapiens (Human))	BDBM409966 (2-oxo-4- tetrahydropyran- 4-yloxy-1H- quinoline- 3...) Show SMILES O=c1[nH]c2ccccc2c(OC2CCOCC2)c1C#N Show InChI	PDB UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem	US Patent	135	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck, Sharp & Dohme Corp. US Patent					Assay Description Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...				US Patent US10370337 (2019) BindingDB Entry DOI: 10.7270/Q2VM4FMJ
Merck, Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair
Phosphodiesterase (PDE9A2) (Homo sapiens (Human))	BDBM409967 (2-oxo-4-(2- hydroxymethyl- 2-methyl-1- butyloxy)- ...) Show SMILES CCC(C)(CO)COc1c(C#N)c(=O)[nH]c2ccccc12 Show InChI	PDB UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem	US Patent	182	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck, Sharp & Dohme Corp. US Patent					Assay Description Human PDE9 (PDE9A2, GenBank Accession No. NM_001001567), full length with N-terminal GST tag, was purchased from BPS Bioscience. The fluorescence pol...				US Patent US10370337 (2019) BindingDB Entry DOI: 10.7270/Q2VM4FMJ
Merck, Sharp & Dohme Corp. US Patent					More data for this Ligand-Target Pair

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Change energy units to:kcal/mole

* indicates data uncertainty>20%