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Patent code US10370338

Compile Data Set for Download or QSAR
Found 50 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Toll-like receptor 8


(Homo sapiens (Human))
BDBM409972
PNG
(2-Amino-8-[3-(anilinomethyl)azetidine-1-carbonyl]-...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CC(CNc2ccccc2)C1
Show InChI InChI=1S/C28H35N5O2/c1-3-12-32(13-4-2)28(35)23-14-21-10-11-22(15-25(21)31-26(29)16-23)27(34)33-18-20(19-33)17-30-24-8-6-5-7-9-24/h5-11,14-15,20,30H,3-4,12-13,16-19H2,1-2H3,(H2,29,31)
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n/an/an/an/a 10n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM409990
PNG
(2-Amino-8-[3-[(E)-but-2-enoxy]azetidine-1-carbonyl...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CC(C1)OC\C=C\C
Show InChI InChI=1S/C25H34N4O3/c1-4-7-12-32-21-16-29(17-21)24(30)19-9-8-18-13-20(15-23(26)27-22(18)14-19)25(31)28(10-5-2)11-6-3/h4,7-9,13-14,21H,5-6,10-12,15-17H2,1-3H3,(H2,26,27)/b7-4+
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n/an/an/an/a 12n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM409978
PNG
(2-Amino-8-(4-benzylpiperazine-1-carbonyl)-N,N-dipr...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C29H37N5O2/c1-3-12-33(13-4-2)29(36)25-18-23-10-11-24(19-26(23)31-27(30)20-25)28(35)34-16-14-32(15-17-34)21-22-8-6-5-7-9-22/h5-11,18-19H,3-4,12-17,20-21H2,1-2H3,(H2,30,31)
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n/an/an/an/a 1.40E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM409982
PNG
(2-Amino-8-(7-phenyl-2,7-diazaspiro[3.5]nonane-2-ca...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CC2(C1)CCN(CC2)c1ccccc1
Show InChI InChI=1S/C31H39N5O2/c1-3-14-35(15-4-2)30(38)25-18-23-10-11-24(19-27(23)33-28(32)20-25)29(37)36-21-31(22-36)12-16-34(17-13-31)26-8-6-5-7-9-26/h5-11,18-19H,3-4,12-17,20-22H2,1-2H3,(H2,32,33)
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n/an/an/an/a 9n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM409983
PNG
(2-Amino-8-(8-phenyl-3,8-diazabicyclo[3.2.1]octane-...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CC2CCC(C1)N2c1ccccc1
Show InChI InChI=1S/C30H37N5O2/c1-3-14-33(15-4-2)30(37)23-16-21-10-11-22(17-27(21)32-28(31)18-23)29(36)34-19-25-12-13-26(20-34)35(25)24-8-6-5-7-9-24/h5-11,16-17,25-26H,3-4,12-15,18-20H2,1-2H3,(H2,31,32)
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n/an/an/an/a 10n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM409983
PNG
(2-Amino-8-(8-phenyl-3,8-diazabicyclo[3.2.1]octane-...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CC2CCC(C1)N2c1ccccc1
Show InChI InChI=1S/C30H37N5O2/c1-3-14-33(15-4-2)30(37)23-16-21-10-11-22(17-27(21)32-28(31)18-23)29(36)34-19-25-12-13-26(20-34)35(25)24-8-6-5-7-9-24/h5-11,16-17,25-26H,3-4,12-15,18-20H2,1-2H3,(H2,31,32)
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n/an/an/an/a 1.60E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM409985
PNG
(2-Amino-8-[3-(benzylamino)azetidine-1-carbonyl]-N,...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CC(C1)NCc1ccccc1
Show InChI InChI=1S/C28H35N5O2/c1-3-12-32(13-4-2)28(35)23-14-21-10-11-22(15-25(21)31-26(29)16-23)27(34)33-18-24(19-33)30-17-20-8-6-5-7-9-20/h5-11,14-15,24,30H,3-4,12-13,16-19H2,1-2H3,(H2,29,31)
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n/an/an/an/a 18n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM409969
PNG
(2-Amino-N,N-dipropyl-8-[6-(p-tolyl)-2,6-diazaspiro...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CC2(C1)CN(C2)c1ccc(C)cc1
Show InChI InChI=1S/C30H37N5O2/c1-4-12-33(13-5-2)29(37)24-14-22-8-9-23(15-26(22)32-27(31)16-24)28(36)35-19-30(20-35)17-34(18-30)25-10-6-21(3)7-11-25/h6-11,14-15H,4-5,12-13,16-20H2,1-3H3,(H2,31,32)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM409973
PNG
(2-Amino-8-(3-anilinopyrrolidine-1-carbonyl)-N,N-di...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CCC(C1)Nc1ccccc1
Show InChI InChI=1S/C28H35N5O2/c1-3-13-32(14-4-2)28(35)22-16-20-10-11-21(17-25(20)31-26(29)18-22)27(34)33-15-12-24(19-33)30-23-8-6-5-7-9-23/h5-11,16-17,24,30H,3-4,12-15,18-19H2,1-2H3,(H2,29,31)
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n/an/an/an/a 4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM409979
PNG
(2-Amino-8-(3-benzyloxyazetidine-1-carbonyl)-N,N-di...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CC(C1)OCc1ccccc1
Show InChI InChI=1S/C28H34N4O3/c1-3-12-31(13-4-2)28(34)23-14-21-10-11-22(15-25(21)30-26(29)16-23)27(33)32-17-24(18-32)35-19-20-8-6-5-7-9-20/h5-11,14-15,24H,3-4,12-13,16-19H2,1-2H3,(H2,29,30)
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n/an/an/an/a 4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM409981
PNG
(2-Amino-8-(2-phenyl-2,7-diazaspiro[3.5]nonane-7-ca...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CCC2(CN(C2)c2ccccc2)CC1
Show InChI InChI=1S/C31H39N5O2/c1-3-14-34(15-4-2)30(38)25-18-23-10-11-24(19-27(23)33-28(32)20-25)29(37)35-16-12-31(13-17-35)21-36(22-31)26-8-6-5-7-9-26/h5-11,18-19H,3-4,12-17,20-22H2,1-2H3,(H2,32,33)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM409985
PNG
(2-Amino-8-[3-(benzylamino)azetidine-1-carbonyl]-N,...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CC(C1)NCc1ccccc1
Show InChI InChI=1S/C28H35N5O2/c1-3-12-32(13-4-2)28(35)23-14-21-10-11-22(15-25(21)31-26(29)16-23)27(34)33-18-24(19-33)30-17-20-8-6-5-7-9-20/h5-11,14-15,24,30H,3-4,12-13,16-19H2,1-2H3,(H2,29,31)
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n/an/an/an/a 1.70E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM409986
PNG
(2-Amino-8-[3-[4-(aminomethyl)anilino]pyrrolidine-1...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CCC(C1)Nc1ccc(CN)cc1
Show InChI InChI=1S/C29H38N6O2/c1-3-12-34(13-4-2)29(37)23-15-21-7-8-22(16-26(21)33-27(31)17-23)28(36)35-14-11-25(19-35)32-24-9-5-20(18-30)6-10-24/h5-10,15-16,25,32H,3-4,11-14,17-19,30H2,1-2H3,(H2,31,33)
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n/an/an/an/a 31n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM409986
PNG
(2-Amino-8-[3-[4-(aminomethyl)anilino]pyrrolidine-1...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CCC(C1)Nc1ccc(CN)cc1
Show InChI InChI=1S/C29H38N6O2/c1-3-12-34(13-4-2)29(37)23-15-21-7-8-22(16-26(21)33-27(31)17-23)28(36)35-14-11-25(19-35)32-24-9-5-20(18-30)6-10-24/h5-10,15-16,25,32H,3-4,11-14,17-19,30H2,1-2H3,(H2,31,33)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM409987
PNG
(2-Amino-8-[3-(benzylamino)pyrrolidine-1-carbonyl]-...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CCC(C1)NCc1ccccc1
Show InChI InChI=1S/C29H37N5O2/c1-3-13-33(14-4-2)29(36)24-16-22-10-11-23(17-26(22)32-27(30)18-24)28(35)34-15-12-25(20-34)31-19-21-8-6-5-7-9-21/h5-11,16-17,25,31H,3-4,12-15,18-20H2,1-2H3,(H2,30,32)
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n/an/an/an/a 14n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM409969
PNG
(2-Amino-N,N-dipropyl-8-[6-(p-tolyl)-2,6-diazaspiro...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CC2(C1)CN(C2)c1ccc(C)cc1
Show InChI InChI=1S/C30H37N5O2/c1-4-12-33(13-5-2)29(37)24-14-22-8-9-23(15-26(22)32-27(31)16-24)28(36)35-19-30(20-35)17-34(18-30)25-10-6-21(3)7-11-25/h6-11,14-15H,4-5,12-13,16-20H2,1-3H3,(H2,31,32)
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n/an/an/an/a 5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM409972
PNG
(2-Amino-8-[3-(anilinomethyl)azetidine-1-carbonyl]-...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CC(CNc2ccccc2)C1
Show InChI InChI=1S/C28H35N5O2/c1-3-12-32(13-4-2)28(35)23-14-21-10-11-22(15-25(21)31-26(29)16-23)27(34)33-18-20(19-33)17-30-24-8-6-5-7-9-24/h5-11,14-15,20,30H,3-4,12-13,16-19H2,1-2H3,(H2,29,31)
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n/an/an/an/a 1.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM409974
PNG
(2-Amino-8-(4-phenylpiperazine-1-carbonyl)-N,N-dipr...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C28H35N5O2/c1-3-12-32(13-4-2)28(35)23-18-21-10-11-22(19-25(21)30-26(29)20-23)27(34)33-16-14-31(15-17-33)24-8-6-5-7-9-24/h5-11,18-19H,3-4,12-17,20H2,1-2H3,(H2,29,30)
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n/an/an/an/a 9.00E+3n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM409978
PNG
(2-Amino-8-(4-benzylpiperazine-1-carbonyl)-N,N-dipr...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C29H37N5O2/c1-3-12-33(13-4-2)29(36)25-18-23-10-11-24(19-26(23)31-27(30)20-25)28(35)34-16-14-32(15-17-34)21-22-8-6-5-7-9-22/h5-11,18-19H,3-4,12-17,20-21H2,1-2H3,(H2,30,31)
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n/an/an/an/a 5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM409979
PNG
(2-Amino-8-(3-benzyloxyazetidine-1-carbonyl)-N,N-di...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CC(C1)OCc1ccccc1
Show InChI InChI=1S/C28H34N4O3/c1-3-12-31(13-4-2)28(34)23-14-21-10-11-22(15-25(21)30-26(29)16-23)27(33)32-17-24(18-32)35-19-20-8-6-5-7-9-20/h5-11,14-15,24H,3-4,12-13,16-19H2,1-2H3,(H2,29,30)
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n/an/an/an/a 1.50E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM409982
PNG
(2-Amino-8-(7-phenyl-2,7-diazaspiro[3.5]nonane-2-ca...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CC2(C1)CCN(CC2)c1ccccc1
Show InChI InChI=1S/C31H39N5O2/c1-3-14-35(15-4-2)30(38)25-18-23-10-11-24(19-27(23)33-28(32)20-25)29(37)36-21-31(22-36)12-16-34(17-13-31)26-8-6-5-7-9-26/h5-11,18-19H,3-4,12-17,20-22H2,1-2H3,(H2,32,33)
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n/an/an/an/a 3.30E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM409991
PNG
(2-Amino-8-(3-anilinopiperidine-1-carbonyl)-N,N-dip...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CCCC(C1)Nc1ccccc1
Show InChI InChI=1S/C29H37N5O2/c1-3-14-33(15-4-2)29(36)23-17-21-12-13-22(18-26(21)32-27(30)19-23)28(35)34-16-8-11-25(20-34)31-24-9-6-5-7-10-24/h5-7,9-10,12-13,17-18,25,31H,3-4,8,11,14-16,19-20H2,1-2H3,(H2,30,32)
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n/an/an/an/a 8n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM409993
PNG
(2-Amino-8-(3-butoxyazetidine-1-carbonyl)-N,N-dipro...)
Show SMILES CCCCOC1CN(C1)C(=O)c1ccc2C=C(CC(N)=Nc2c1)C(=O)N(CCC)CCC
Show InChI InChI=1S/C25H36N4O3/c1-4-7-12-32-21-16-29(17-21)24(30)19-9-8-18-13-20(15-23(26)27-22(18)14-19)25(31)28(10-5-2)11-6-3/h8-9,13-14,21H,4-7,10-12,15-17H2,1-3H3,(H2,26,27)
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n/an/an/an/a 3.11E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM409970
PNG
(2-Amino-8-(4-anilinopiperidine-1-carbonyl)-N,N-dip...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CCC(CC1)Nc1ccccc1
Show InChI InChI=1S/C29H37N5O2/c1-3-14-33(15-4-2)29(36)23-18-21-10-11-22(19-26(21)32-27(30)20-23)28(35)34-16-12-25(13-17-34)31-24-8-6-5-7-9-24/h5-11,18-19,25,31H,3-4,12-17,20H2,1-2H3,(H2,30,32)
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n/an/an/an/a 7.90E+3n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM409971
PNG
(2-Amino-8-(3-anilinoazetidine-1-carbonyl)-N,N-dipr...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CC(C1)Nc1ccccc1
Show InChI InChI=1S/C27H33N5O2/c1-3-12-31(13-4-2)27(34)21-14-19-10-11-20(15-24(19)30-25(28)16-21)26(33)32-17-23(18-32)29-22-8-6-5-7-9-22/h5-11,14-15,23,29H,3-4,12-13,16-18H2,1-2H3,(H2,28,30)
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n/an/an/an/a 5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM409973
PNG
(2-Amino-8-(3-anilinopyrrolidine-1-carbonyl)-N,N-di...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CCC(C1)Nc1ccccc1
Show InChI InChI=1S/C28H35N5O2/c1-3-13-32(14-4-2)28(35)22-16-20-10-11-21(17-25(20)31-26(29)18-22)27(34)33-15-12-24(19-33)30-23-8-6-5-7-9-23/h5-11,16-17,24,30H,3-4,12-15,18-19H2,1-2H3,(H2,29,31)
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n/an/an/an/a 1.40E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM409974
PNG
(2-Amino-8-(4-phenylpiperazine-1-carbonyl)-N,N-dipr...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C28H35N5O2/c1-3-12-32(13-4-2)28(35)23-18-21-10-11-22(19-25(21)30-26(29)20-23)27(34)33-16-14-31(15-17-33)24-8-6-5-7-9-24/h5-11,18-19H,3-4,12-17,20H2,1-2H3,(H2,29,30)
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n/an/an/an/a 25n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM409975
PNG
(2-Amino-8-(7-phenyl-2,7-diazaspiro[3.4]octane-2-ca...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CC2(C1)CCN(C2)c1ccccc1
Show InChI InChI=1S/C30H37N5O2/c1-3-13-33(14-4-2)29(37)24-16-22-10-11-23(17-26(22)32-27(31)18-24)28(36)35-20-30(21-35)12-15-34(19-30)25-8-6-5-7-9-25/h5-11,16-17H,3-4,12-15,18-21H2,1-2H3,(H2,31,32)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM409976
PNG
(2-Amino-N,N-dipropyl-8-(pyrrolidine-1-carbonyl)-3H...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CCCC1
Show InChI InChI=1S/C22H30N4O2/c1-3-9-25(10-4-2)22(28)18-13-16-7-8-17(14-19(16)24-20(23)15-18)21(27)26-11-5-6-12-26/h7-8,13-14H,3-6,9-12,15H2,1-2H3,(H2,23,24)
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n/an/an/an/a 15n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM409976
PNG
(2-Amino-N,N-dipropyl-8-(pyrrolidine-1-carbonyl)-3H...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CCCC1
Show InChI InChI=1S/C22H30N4O2/c1-3-9-25(10-4-2)22(28)18-13-16-7-8-17(14-19(16)24-20(23)15-18)21(27)26-11-5-6-12-26/h7-8,13-14H,3-6,9-12,15H2,1-2H3,(H2,23,24)
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n/an/an/an/a 2.10E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM409980
PNG
(2-Amino-8-(6-phenyl-3,6-diazabicyclo[3.1.1]heptane...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CC2CC(C1)N2c1ccccc1
Show InChI InChI=1S/C29H35N5O2/c1-3-12-32(13-4-2)29(36)22-14-20-10-11-21(15-26(20)31-27(30)16-22)28(35)33-18-24-17-25(19-33)34(24)23-8-6-5-7-9-23/h5-11,14-15,24-25H,3-4,12-13,16-19H2,1-2H3,(H2,30,31)
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n/an/an/an/a 22n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM409992
PNG
(2-Amino-8-[3-(benzylamino)piperidine-1-carbonyl]-N...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CCCC(C1)NCc1ccccc1
Show InChI InChI=1S/C30H39N5O2/c1-3-14-34(15-4-2)30(37)25-17-23-12-13-24(18-27(23)33-28(31)19-25)29(36)35-16-8-11-26(21-35)32-20-22-9-6-5-7-10-22/h5-7,9-10,12-13,17-18,26,32H,3-4,8,11,14-16,19-21H2,1-2H3,(H2,31,33)
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n/an/an/an/a 14n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM409993
PNG
(2-Amino-8-(3-butoxyazetidine-1-carbonyl)-N,N-dipro...)
Show SMILES CCCCOC1CN(C1)C(=O)c1ccc2C=C(CC(N)=Nc2c1)C(=O)N(CCC)CCC
Show InChI InChI=1S/C25H36N4O3/c1-4-7-12-32-21-16-29(17-21)24(30)19-9-8-18-13-20(15-23(26)27-22(18)14-19)25(31)28(10-5-2)11-6-3/h8-9,13-14,21H,4-7,10-12,15-17H2,1-3H3,(H2,26,27)
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n/an/an/an/a 8n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM409981
PNG
(2-Amino-8-(2-phenyl-2,7-diazaspiro[3.5]nonane-7-ca...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CCC2(CN(C2)c2ccccc2)CC1
Show InChI InChI=1S/C31H39N5O2/c1-3-14-34(15-4-2)30(38)25-18-23-10-11-24(19-27(23)33-28(32)20-25)29(37)35-16-12-31(13-17-35)21-36(22-31)26-8-6-5-7-9-26/h5-11,18-19H,3-4,12-17,20-22H2,1-2H3,(H2,32,33)
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n/an/an/an/a 7n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM409984
PNG
(2-Amino-8-(6-phenyl-3,6-diazabicyclo[3.2.0]heptane...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CC2CN(C2C1)c1ccccc1
Show InChI InChI=1S/C29H35N5O2/c1-3-12-32(13-4-2)29(36)22-14-20-10-11-21(15-25(20)31-27(30)16-22)28(35)33-17-23-18-34(26(23)19-33)24-8-6-5-7-9-24/h5-11,14-15,23,26H,3-4,12-13,16-19H2,1-2H3,(H2,30,31)
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n/an/an/an/a 29n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM409988
PNG
(2-amino-8-[4-(anilinomethyl)piperidine-1-carbonyl]...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CCC(CNc2ccccc2)CC1
Show InChI InChI=1S/C30H39N5O2/c1-3-14-34(15-4-2)30(37)25-18-23-10-11-24(19-27(23)33-28(31)20-25)29(36)35-16-12-22(13-17-35)21-32-26-8-6-5-7-9-26/h5-11,18-19,22,32H,3-4,12-17,20-21H2,1-2H3,(H2,31,33)
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n/an/an/an/a 20n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM409989
PNG
(2-Amino-8-[3-(anilinomethyl)pyrrolidine-1-carbonyl...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CCC(CNc2ccccc2)C1
Show InChI InChI=1S/C29H37N5O2/c1-3-13-33(14-4-2)29(36)24-16-22-10-11-23(17-26(22)32-27(30)18-24)28(35)34-15-12-21(20-34)19-31-25-8-6-5-7-9-25/h5-11,16-17,21,31H,3-4,12-15,18-20H2,1-2H3,(H2,30,32)
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n/an/an/an/a 9n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM409990
PNG
(2-Amino-8-[3-[(E)-but-2-enoxy]azetidine-1-carbonyl...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CC(C1)OC\C=C\C
Show InChI InChI=1S/C25H34N4O3/c1-4-7-12-32-21-16-29(17-21)24(30)19-9-8-18-13-20(15-23(26)27-22(18)14-19)25(31)28(10-5-2)11-6-3/h4,7-9,13-14,21H,5-6,10-12,15-17H2,1-3H3,(H2,26,27)/b7-4+
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n/an/an/an/a 3.20E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM409975
PNG
(2-Amino-8-(7-phenyl-2,7-diazaspiro[3.4]octane-2-ca...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CC2(C1)CCN(C2)c1ccccc1
Show InChI InChI=1S/C30H37N5O2/c1-3-13-33(14-4-2)29(37)24-16-22-10-11-23(17-26(22)32-27(31)18-24)28(36)35-20-30(21-35)12-15-34(19-30)25-8-6-5-7-9-25/h5-11,16-17H,3-4,12-15,18-21H2,1-2H3,(H2,31,32)
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n/an/an/an/a 10n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM409989
PNG
(2-Amino-8-[3-(anilinomethyl)pyrrolidine-1-carbonyl...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CCC(CNc2ccccc2)C1
Show InChI InChI=1S/C29H37N5O2/c1-3-13-33(14-4-2)29(36)24-16-22-10-11-23(17-26(22)32-27(30)18-24)28(35)34-15-12-21(20-34)19-31-25-8-6-5-7-9-25/h5-11,16-17,21,31H,3-4,12-15,18-20H2,1-2H3,(H2,30,32)
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n/an/an/an/a 6.98E+3n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM409991
PNG
(2-Amino-8-(3-anilinopiperidine-1-carbonyl)-N,N-dip...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CCCC(C1)Nc1ccccc1
Show InChI InChI=1S/C29H37N5O2/c1-3-14-33(15-4-2)29(36)23-17-21-12-13-22(18-26(21)32-27(30)19-23)28(35)34-16-8-11-25(20-34)31-24-9-6-5-7-10-24/h5-7,9-10,12-13,17-18,25,31H,3-4,8,11,14-16,19-20H2,1-2H3,(H2,30,32)
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n/an/an/an/a 400n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM409970
PNG
(2-Amino-8-(4-anilinopiperidine-1-carbonyl)-N,N-dip...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CCC(CC1)Nc1ccccc1
Show InChI InChI=1S/C29H37N5O2/c1-3-14-33(15-4-2)29(36)23-18-21-10-11-22(19-26(21)32-27(30)20-23)28(35)34-16-12-25(13-17-34)31-24-8-6-5-7-9-24/h5-11,18-19,25,31H,3-4,12-17,20H2,1-2H3,(H2,30,32)
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n/an/an/an/a 6n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM409971
PNG
(2-Amino-8-(3-anilinoazetidine-1-carbonyl)-N,N-dipr...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CC(C1)Nc1ccccc1
Show InChI InChI=1S/C27H33N5O2/c1-3-12-31(13-4-2)27(34)21-14-19-10-11-20(15-24(19)30-25(28)16-21)26(33)32-17-23(18-32)29-22-8-6-5-7-9-22/h5-11,14-15,23,29H,3-4,12-13,16-18H2,1-2H3,(H2,28,30)
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n/an/an/an/a 2.40E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM409977
PNG
(2-Amino-8-(4-anilinopiperidine-1-carbonyl)-N-(cycl...)
Show SMILES CCCN(CC1CC1)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CCC(CC1)Nc1ccccc1
Show InChI InChI=1S/C30H37N5O2/c1-2-14-35(20-21-8-9-21)30(37)24-17-22-10-11-23(18-27(22)33-28(31)19-24)29(36)34-15-12-26(13-16-34)32-25-6-4-3-5-7-25/h3-7,10-11,17-18,21,26,32H,2,8-9,12-16,19-20H2,1H3,(H2,31,33)
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n/an/an/an/a 1.80E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM409988
PNG
(2-amino-8-[4-(anilinomethyl)piperidine-1-carbonyl]...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CCC(CNc2ccccc2)CC1
Show InChI InChI=1S/C30H39N5O2/c1-3-14-34(15-4-2)30(37)25-18-23-10-11-24(19-27(23)33-28(31)20-25)29(36)35-16-12-22(13-17-35)21-32-26-8-6-5-7-9-26/h5-11,18-19,22,32H,3-4,12-17,20-21H2,1-2H3,(H2,31,33)
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n/an/an/an/a 1.00E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM409992
PNG
(2-Amino-8-[3-(benzylamino)piperidine-1-carbonyl]-N...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CCCC(C1)NCc1ccccc1
Show InChI InChI=1S/C30H39N5O2/c1-3-14-34(15-4-2)30(37)25-17-23-12-13-24(18-27(23)33-28(31)19-25)29(36)35-16-8-11-26(21-35)32-20-22-9-6-5-7-10-22/h5-7,9-10,12-13,17-18,26,32H,3-4,8,11,14-16,19-21H2,1-2H3,(H2,31,33)
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n/an/an/an/a 3.10E+3n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM409980
PNG
(2-Amino-8-(6-phenyl-3,6-diazabicyclo[3.1.1]heptane...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CC2CC(C1)N2c1ccccc1
Show InChI InChI=1S/C29H35N5O2/c1-3-12-32(13-4-2)29(36)22-14-20-10-11-21(15-26(20)31-27(30)16-22)28(35)33-18-24-17-25(19-33)34(24)23-8-6-5-7-9-23/h5-11,14-15,24-25H,3-4,12-13,16-19H2,1-2H3,(H2,30,31)
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n/an/an/an/a 1.10E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM409984
PNG
(2-Amino-8-(6-phenyl-3,6-diazabicyclo[3.2.0]heptane...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CC2CN(C2C1)c1ccccc1
Show InChI InChI=1S/C29H35N5O2/c1-3-12-32(13-4-2)29(36)22-14-20-10-11-21(15-25(20)31-27(30)16-22)28(35)33-17-23-18-34(26(23)19-33)24-8-6-5-7-9-24/h5-11,14-15,23,26H,3-4,12-13,16-19H2,1-2H3,(H2,30,31)
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n/an/an/an/a 1.20E+4n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM409987
PNG
(2-Amino-8-[3-(benzylamino)pyrrolidine-1-carbonyl]-...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CCC(C1)NCc1ccccc1
Show InChI InChI=1S/C29H37N5O2/c1-3-13-33(14-4-2)29(36)24-16-22-10-11-23(17-26(22)32-27(30)18-24)28(35)34-15-12-25(20-34)31-19-21-8-6-5-7-9-21/h5-11,16-17,25,31H,3-4,12-15,18-20H2,1-2H3,(H2,30,32)
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n/an/an/an/a 6.60E+3n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM409977
PNG
(2-Amino-8-(4-anilinopiperidine-1-carbonyl)-N-(cycl...)
Show SMILES CCCN(CC1CC1)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CCC(CC1)Nc1ccccc1
Show InChI InChI=1S/C30H37N5O2/c1-2-14-35(20-21-8-9-21)30(37)24-17-22-10-11-23(18-27(22)33-28(31)19-24)29(36)34-15-12-26(13-16-34)32-25-6-4-3-5-7-25/h3-7,10-11,17-18,21,26,32H,2,8-9,12-16,19-20H2,1H3,(H2,31,33)
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n/an/an/an/a 20n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US10370338 (2019)


BindingDB Entry DOI: 10.7270/Q2QV3PVC
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%