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Patent code US10370352

Compile Data Set for Download or QSAR
Found 7 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM410042
PNG
(1-[3-(4-Cyclopropylimidazol-1-yl)cyclobutyl]-3-[6-...)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)N1CCN(C2CC(C2)n2cnc(c2)C2CC2)C1=O
Show InChI InChI=1S/C23H28N8O/c1-15(2)31-14-25-27-22(31)19-4-3-5-21(26-19)30-9-8-29(23(30)32)18-10-17(11-18)28-12-20(24-13-28)16-6-7-16/h3-5,12-18H,6-11H2,1-2H3
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n/an/a 1.47n/an/an/an/an/an/a



ELI LILLY AND COMPANY

US Patent


Assay Description
The assay is done using an ADP-Glo Kinase Assay Kit (Promega, Catalog #V9102) according to the manufacturer's protocol with the following modific...


US Patent US10370352 (2019)


BindingDB Entry DOI: 10.7270/Q2GB26D1
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM410045
PNG
(1-(3-(4-(tert-Butyl)-1H-imidazol-1-yl)cyclobutyl)-...)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)N1CCN(C2CC(C2)n2cnc(c2)C(C)(C)C)C1=O
Show InChI InChI=1S/C24H32N8O/c1-16(2)32-15-26-28-22(32)19-7-6-8-21(27-19)31-10-9-30(23(31)33)18-11-17(12-18)29-13-20(25-14-29)24(3,4)5/h6-8,13-18H,9-12H2,1-5H3
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n/an/a 1.84n/an/an/an/an/an/a



ELI LILLY AND COMPANY

US Patent


Assay Description
The assay is done using an ADP-Glo Kinase Assay Kit (Promega, Catalog #V9102) according to the manufacturer's protocol with the following modific...


US Patent US10370352 (2019)


BindingDB Entry DOI: 10.7270/Q2GB26D1
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM410046
PNG
(1-[3-(1-Isopropylpyrazol-4-yl)cyclobutyl]-3-[6-(4-...)
Show SMILES CC(C)[N]1=CC(C=N1)C1CC(C1)N1CCN(C1=O)c1cccc(n1)-c1nncn1C(C)C
Show InChI InChI=1S/C23H31N8O/c1-15(2)30-14-24-27-22(30)20-6-5-7-21(26-20)29-9-8-28(23(29)32)19-10-17(11-19)18-12-25-31(13-18)16(3)4/h5-7,12-19H,8-11H2,1-4H3
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n/an/a 2.17n/an/an/an/an/an/a



ELI LILLY AND COMPANY

US Patent


Assay Description
The assay is done using an ADP-Glo Kinase Assay Kit (Promega, Catalog #V9102) according to the manufacturer's protocol with the following modific...


US Patent US10370352 (2019)


BindingDB Entry DOI: 10.7270/Q2GB26D1
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM410044
PNG
(1-[3-(3-Cyclopropyl-1,2,4-triazol-1-yl)cyclobutyl]...)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)N1CCN(C2CC(C2)n2cnc(n2)C2CC2)C1=O
Show InChI InChI=1S/C22H27N9O/c1-14(2)30-13-24-26-21(30)18-4-3-5-19(25-18)29-9-8-28(22(29)32)16-10-17(11-16)31-12-23-20(27-31)15-6-7-15/h3-5,12-17H,6-11H2,1-2H3
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n/an/a 2.56n/an/an/an/an/an/a



ELI LILLY AND COMPANY

US Patent


Assay Description
The assay is done using an ADP-Glo Kinase Assay Kit (Promega, Catalog #V9102) according to the manufacturer's protocol with the following modific...


US Patent US10370352 (2019)


BindingDB Entry DOI: 10.7270/Q2GB26D1
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM410043
PNG
(1-(6-(4-Isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-...)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)N1CCN(C2CC(C2)n2cnc(c2)C(F)(F)F)C1=O
Show InChI InChI=1S/C21H23F3N8O/c1-13(2)32-12-26-28-19(32)16-4-3-5-18(27-16)31-7-6-30(20(31)33)15-8-14(9-15)29-10-17(25-11-29)21(22,23)24/h3-5,10-15H,6-9H2,1-2H3
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n/an/a 2.80n/an/an/an/an/an/a



ELI LILLY AND COMPANY

US Patent


Assay Description
The assay is done using an ADP-Glo Kinase Assay Kit (Promega, Catalog #V9102) according to the manufacturer's protocol with the following modific...


US Patent US10370352 (2019)


BindingDB Entry DOI: 10.7270/Q2GB26D1
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM410047
PNG
(1-[6-(4-Isopropyl-1,2,4-triazol-3-yl)-2-pyridyl]-3...)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)N1CCN(C2CC(C2)c2ccc(C)nc2)C1=O
Show InChI InChI=1S/C23H27N7O/c1-15(2)30-14-25-27-22(30)20-5-4-6-21(26-20)29-10-9-28(23(29)31)19-11-18(12-19)17-8-7-16(3)24-13-17/h4-8,13-15,18-19H,9-12H2,1-3H3
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n/an/a 5.26n/an/an/an/an/an/a



ELI LILLY AND COMPANY

US Patent


Assay Description
The assay is done using an ADP-Glo Kinase Assay Kit (Promega, Catalog #V9102) according to the manufacturer's protocol with the following modific...


US Patent US10370352 (2019)


BindingDB Entry DOI: 10.7270/Q2GB26D1
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM410048
PNG
(1-(6-(4-Isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-...)
Show SMILES CC(C)n1cnnc1-c1cccc(n1)N1CCN(C2CC(C2)c2cnc(C)nc2)C1=O
Show InChI InChI=1S/C22H26N8O/c1-14(2)30-13-25-27-21(30)19-5-4-6-20(26-19)29-8-7-28(22(29)31)18-9-16(10-18)17-11-23-15(3)24-12-17/h4-6,11-14,16,18H,7-10H2,1-3H3
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n/an/a 6.21n/an/an/an/an/an/a



ELI LILLY AND COMPANY

US Patent


Assay Description
The assay is done using an ADP-Glo Kinase Assay Kit (Promega, Catalog #V9102) according to the manufacturer's protocol with the following modific...


US Patent US10370352 (2019)


BindingDB Entry DOI: 10.7270/Q2GB26D1
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%