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Patent code US10370360

Compile Data Set for Download or QSAR
Found 160 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410072
PNG
(D2473 | US10370360, Example 24)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CC[C@H](C2)N(C)C)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C29H33F3N6O/c1-19-14-38(26-12-33-18-34-13-26)16-22-10-21(4-5-27(19)22)28(39)35-24-9-20(8-23(11-24)29(30,31)32)15-37-7-6-25(17-37)36(2)3/h4-5,8-13,18-19,25H,6-7,14-17H2,1-3H3,(H,35,39)/t19?,25-/m1/s1
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n/an/a 18n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410074
PNG
(D2202 | US10370360, Example 26)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(cc(c1)C(F)(F)F)-n1cnc(C)c1)c1cncnc1
Show InChI InChI=1S/C26H23F3N6O/c1-16-11-34(23-9-30-14-31-10-23)13-19-5-18(3-4-24(16)19)25(36)33-21-6-20(26(27,28)29)7-22(8-21)35-12-17(2)32-15-35/h3-10,12,14-16H,11,13H2,1-2H3,(H,33,36)
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n/an/a 19.4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410060
PNG
(D2190 | US10370360, Example 12)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1ccc(CN2CCN(C)CC2)c(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C28H31F3N6O/c1-19-15-37(24-13-32-18-33-14-24)17-22-11-20(4-6-25(19)22)27(38)34-23-5-3-21(26(12-23)28(29,30)31)16-36-9-7-35(2)8-10-36/h3-6,11-14,18-19H,7-10,15-17H2,1-2H3,(H,34,38)
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n/an/a 19.9n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410080
PNG
(D2196 | US10370360, Example 32)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C1CCCC1)c1cncnc1
Show InChI InChI=1S/C32H40N6O/c1-23-19-38(30-17-33-22-34-18-30)21-28-15-26(7-8-31(23)28)32(39)35-29-14-24(20-37-11-9-36(2)10-12-37)13-27(16-29)25-5-3-4-6-25/h7-8,13-18,22-23,25H,3-6,9-12,19-21H2,1-2H3,(H,35,39)
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n/an/a 20.6n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410062
PNG
(D2197 | US10370360, Example 14)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCCN(C)CC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C29H33F3N6O/c1-20-16-38(26-14-33-19-34-15-26)18-23-12-22(4-5-27(20)23)28(39)35-25-11-21(10-24(13-25)29(30,31)32)17-37-7-3-6-36(2)8-9-37/h4-5,10-15,19-20H,3,6-9,16-18H2,1-2H3,(H,35,39)
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n/an/a 25.6n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410073
PNG
(D2475 | US10370360, Example 25)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CC[C@@H](C2)N(C)C)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C29H33F3N6O/c1-19-14-38(26-12-33-18-34-13-26)16-22-10-21(4-5-27(19)22)28(39)35-24-9-20(8-23(11-24)29(30,31)32)15-37-7-6-25(17-37)36(2)3/h4-5,8-13,18-19,25H,6-7,14-17H2,1-3H3,(H,35,39)/t19?,25-/m0/s1
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n/an/a 29.6n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410071
PNG
(D2474 | US10370360, Example 23)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN(C)CCN(C)C)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C28H33F3N6O/c1-19-15-37(25-13-32-18-33-14-25)17-22-11-21(5-6-26(19)22)27(38)34-24-10-20(9-23(12-24)28(29,30)31)16-36(4)8-7-35(2)3/h5-6,9-14,18-19H,7-8,15-17H2,1-4H3,(H,34,38)
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n/an/a 31.4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410064
PNG
(D2187 | US10370360, Example 16)
Show SMILES CC(C)c1cc(CN2CCN(C)CC2)cc(NC(=O)c2ccc3C(C)CN(Cc3c2)c2cncnc2)c1
Show InChI InChI=1S/C30H38N6O/c1-21(2)25-11-23(18-35-9-7-34(4)8-10-35)12-27(14-25)33-30(37)24-5-6-29-22(3)17-36(19-26(29)13-24)28-15-31-20-32-16-28/h5-6,11-16,20-22H,7-10,17-19H2,1-4H3,(H,33,37)
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n/an/a 35.7n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410058
PNG
(D2276 | US10370360, Example 10)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CCN2CCN(C)CC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C29H33F3N6O/c1-20-17-38(26-15-33-19-34-16-26)18-23-13-22(3-4-27(20)23)28(39)35-25-12-21(11-24(14-25)29(30,31)32)5-6-37-9-7-36(2)8-10-37/h3-4,11-16,19-20H,5-10,17-18H2,1-2H3,(H,35,39)
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n/an/a 36.7n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410049
PNG
(D2095 | US10370360, Example 1)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C28H31F3N6O/c1-19-15-37(25-13-32-18-33-14-25)17-22-11-21(3-4-26(19)22)27(38)34-24-10-20(9-23(12-24)28(29,30)31)16-36-7-5-35(2)6-8-36/h3-4,9-14,18-19H,5-8,15-17H2,1-2H3,(H,34,38)
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n/an/a 38.3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410065
PNG
(D2275 | US10370360, Example 17)
Show SMILES CCN1CCN(Cc2cc(NC(=O)c3ccc4C(C)CN(Cc4c3)c3cncnc3)cc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C29H33F3N6O/c1-3-36-6-8-37(9-7-36)17-21-10-24(29(30,31)32)13-25(11-21)35-28(39)22-4-5-27-20(2)16-38(18-23(27)12-22)26-14-33-19-34-15-26/h4-5,10-15,19-20H,3,6-9,16-18H2,1-2H3,(H,35,39)
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n/an/a 39.1n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM50260033
PNG
(CHEMBL4066114 | US10370360, Example 38)
Show SMILES C[C@H]1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C28H31F3N6O/c1-19-15-37(25-13-32-18-33-14-25)17-22-11-21(3-4-26(19)22)27(38)34-24-10-20(9-23(12-24)28(29,30)31)16-36-7-5-35(2)6-8-36/h3-4,9-14,18-19H,5-8,15-17H2,1-2H3,(H,34,38)/t19-/m0/s1
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n/an/a 42.6n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410077
PNG
(D2476 | US10370360, Example 29)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)-c1ccccc1)c1cncnc1
Show InChI InChI=1S/C33H36N6O/c1-24-20-39(31-18-34-23-35-19-31)22-29-16-27(8-9-32(24)29)33(40)36-30-15-25(21-38-12-10-37(2)11-13-38)14-28(17-30)26-6-4-3-5-7-26/h3-9,14-19,23-24H,10-13,20-22H2,1-2H3,(H,36,40)
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n/an/a 44.6n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410075
PNG
(D2214 | US10370360, Example 27)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)c(F)c(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C28H30F4N6O/c1-18-14-38(23-12-33-17-34-13-23)16-20-9-19(3-4-24(18)20)27(39)35-22-10-21(15-37-7-5-36(2)6-8-37)26(29)25(11-22)28(30,31)32/h3-4,9-13,17-18H,5-8,14-16H2,1-2H3,(H,35,39)
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n/an/a 48.8n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410063
PNG
(D2193 | US10370360, Example 15)
Show SMILES CCc1cc(CN2CCN(C)CC2)cc(NC(=O)c2ccc3C(C)CN(Cc3c2)c2cncnc2)c1
Show InChI InChI=1S/C29H36N6O/c1-4-22-11-23(18-34-9-7-33(3)8-10-34)13-26(12-22)32-29(36)24-5-6-28-21(2)17-35(19-25(28)14-24)27-15-30-20-31-16-27/h5-6,11-16,20-21H,4,7-10,17-19H2,1-3H3,(H,32,36)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410056
PNG
(D2198 | US10370360, Example 8)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)c(Cl)c(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C28H30ClF3N6O/c1-18-14-38(23-12-33-17-34-13-23)16-20-9-19(3-4-24(18)20)27(39)35-22-10-21(15-37-7-5-36(2)6-8-37)26(29)25(11-22)28(30,31)32/h3-4,9-13,17-18H,5-8,14-16H2,1-2H3,(H,35,39)
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n/an/a 65.9n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM50260029
PNG
(CHEMBL4088388 | US10370360, Example 40)
Show SMILES C[C@H]1CN(Cc2cc(NC(=O)c3cc(CN4CCN(C)CC4)cc(c3)C(F)(F)F)ccc12)c1cncnc1
Show InChI InChI=1S/C28H31F3N6O/c1-19-15-37(25-13-32-18-33-14-25)17-22-12-24(3-4-26(19)22)34-27(38)21-9-20(10-23(11-21)28(29,30)31)16-36-7-5-35(2)6-8-36/h3-4,9-14,18-19H,5-8,15-17H2,1-2H3,(H,34,38)/t19-/m0/s1
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n/an/a 66.2n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410076
PNG
(D2350 | US10370360, Example 28)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(C)(C)C)c1cncnc1
Show InChI InChI=1S/C31H40N6O/c1-22-18-37(28-16-32-21-33-17-28)20-25-14-24(6-7-29(22)25)30(38)34-27-13-23(12-26(15-27)31(2,3)4)19-36-10-8-35(5)9-11-36/h6-7,12-17,21-22H,8-11,18-20H2,1-5H3,(H,34,38)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410054
PNG
(D2103 | US10370360, Example 6)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F)c1cccnc1
Show InChI InChI=1S/C29H32F3N5O/c1-20-17-37(26-4-3-7-33-16-26)19-23-14-22(5-6-27(20)23)28(38)34-25-13-21(12-24(15-25)29(30,31)32)18-36-10-8-35(2)9-11-36/h3-7,12-16,20H,8-11,17-19H2,1-2H3,(H,34,38)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410070
PNG
(D2215 | US10370360, Example 22)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C1CCCCC1)c1cncnc1
Show InChI InChI=1S/C33H42N6O/c1-24-20-39(31-18-34-23-35-19-31)22-29-16-27(8-9-32(24)29)33(40)36-30-15-25(21-38-12-10-37(2)11-13-38)14-28(17-30)26-6-4-3-5-7-26/h8-9,14-19,23-24,26H,3-7,10-13,20-22H2,1-2H3,(H,36,40)
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n/an/a 71.6n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410081
PNG
(D2195 | US10370360, Example 33)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(CC2)C2CCCCC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C33H39F3N6O/c1-23-19-42(30-17-37-22-38-18-30)21-26-15-25(7-8-31(23)26)32(43)39-28-14-24(13-27(16-28)33(34,35)36)20-40-9-11-41(12-10-40)29-5-3-2-4-6-29/h7-8,13-18,22-23,29H,2-6,9-12,19-21H2,1H3,(H,39,43)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410082
PNG
(D2213 | US10370360, Example 34)
Show SMILES CCC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C29H33F3N6O/c1-3-21-17-38(26-14-33-19-34-15-26)18-23-12-22(4-5-27(21)23)28(39)35-25-11-20(10-24(13-25)29(30,31)32)16-37-8-6-36(2)7-9-37/h4-5,10-15,19,21H,3,6-9,16-18H2,1-2H3,(H,35,39)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410079
PNG
(D2347 | US10370360, Example 31)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C1CC1)c1cncnc1
Show InChI InChI=1S/C30H36N6O/c1-21-17-36(28-15-31-20-32-16-28)19-26-13-24(5-6-29(21)26)30(37)33-27-12-22(11-25(14-27)23-3-4-23)18-35-9-7-34(2)8-10-35/h5-6,11-16,20-21,23H,3-4,7-10,17-19H2,1-2H3,(H,33,37)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410059
PNG
(D2188 | US10370360, Example 11)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(cc(c1)C(F)(F)F)N1CCN(C)CC1)c1cncnc1
Show InChI InChI=1S/C27H29F3N6O/c1-18-15-36(24-13-31-17-32-14-24)16-20-9-19(3-4-25(18)20)26(37)33-22-10-21(27(28,29)30)11-23(12-22)35-7-5-34(2)6-8-35/h3-4,9-14,17-18H,5-8,15-16H2,1-2H3,(H,33,37)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410057
PNG
(D2274 | US10370360, Example 9)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)c(C)c(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C29H33F3N6O/c1-19-15-38(25-13-33-18-34-14-25)17-23-10-21(4-5-26(19)23)28(39)35-24-11-22(16-37-8-6-36(3)7-9-37)20(2)27(12-24)29(30,31)32/h4-5,10-14,18-19H,6-9,15-17H2,1-3H3,(H,35,39)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410067
PNG
(D2194 | US10370360, Example 19)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCCCC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C28H30F3N5O/c1-19-15-36(25-13-32-18-33-14-25)17-22-11-21(5-6-26(19)22)27(37)34-24-10-20(9-23(12-24)28(29,30)31)16-35-7-3-2-4-8-35/h5-6,9-14,18-19H,2-4,7-8,15-17H2,1H3,(H,34,37)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410061
PNG
(D2199 | US10370360, Example 13)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cccc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C22H19F3N4O/c1-14-11-29(19-9-26-13-27-10-19)12-16-7-15(5-6-20(14)16)21(30)28-18-4-2-3-17(8-18)22(23,24)25/h2-10,13-14H,11-12H2,1H3,(H,28,30)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410066
PNG
(D2201 | US10370360, Example 18)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCOCC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C27H28F3N5O2/c1-18-14-35(24-12-31-17-32-13-24)16-21-10-20(2-3-25(18)21)26(36)33-23-9-19(8-22(11-23)27(28,29)30)15-34-4-6-37-7-5-34/h2-3,8-13,17-18H,4-7,14-16H2,1H3,(H,33,36)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410083
PNG
(D2191 | US10370360, Example 35)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCSCC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C27H28F3N5OS/c1-18-14-35(24-12-31-17-32-13-24)16-21-10-20(2-3-25(18)21)26(36)33-23-9-19(8-22(11-23)27(28,29)30)15-34-4-6-37-7-5-34/h2-3,8-13,17-18H,4-7,14-16H2,1H3,(H,33,36)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410068
PNG
(D2573 | US10370360, Example 20)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCCC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C27H28F3N5O/c1-18-14-35(24-12-31-17-32-13-24)16-21-10-20(4-5-25(18)21)26(36)33-23-9-19(15-34-6-2-3-7-34)8-22(11-23)27(28,29)30/h4-5,8-13,17-18H,2-3,6-7,14-16H2,1H3,(H,33,36)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM50260028
PNG
(CHEMBL4068810 | US10370360, Example 7)
Show SMILES CN1CCN(Cc2cc(NC(=O)c3ccc4c(CN(CC4(C)C)c4cncnc4)c3)cc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C29H33F3N6O/c1-28(2)18-38(25-14-33-19-34-15-25)17-22-12-21(4-5-26(22)28)27(39)35-24-11-20(10-23(13-24)29(30,31)32)16-37-8-6-36(3)7-9-37/h4-5,10-15,19H,6-9,16-18H2,1-3H3,(H,35,39)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410069
PNG
(D2192 | US10370360, Example 21)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN(C)C)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C25H26F3N5O/c1-16-12-33(22-10-29-15-30-11-22)14-19-8-18(4-5-23(16)19)24(34)31-21-7-17(13-32(2)3)6-20(9-21)25(26,27)28/h4-11,15-16H,12-14H2,1-3H3,(H,31,34)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410085
PNG
(D2099 | US10370360, Example 37)
Show SMILES C[C@@H]1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C28H31F3N6O/c1-19-15-37(25-13-32-18-33-14-25)17-22-11-21(3-4-26(19)22)27(38)34-24-10-20(9-23(12-24)28(29,30)31)16-36-7-5-35(2)6-8-36/h3-4,9-14,18-19H,5-8,15-17H2,1-2H3,(H,34,38)/t19-/m1/s1
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410080
PNG
(D2196 | US10370360, Example 32)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C1CCCC1)c1cncnc1
Show InChI InChI=1S/C32H40N6O/c1-23-19-38(30-17-33-22-34-18-30)21-28-15-26(7-8-31(23)28)32(39)35-29-14-24(20-37-11-9-36(2)10-12-37)13-27(16-29)25-5-3-4-6-25/h7-8,13-18,22-23,25H,3-6,9-12,19-21H2,1-2H3,(H,35,39)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410052
PNG
(D2211 | US10370360, Example 4)
Show SMILES CN1CCN(Cc2cc(NC(=O)c3ccc4CCN(Cc4c3)c3cccnc3)cc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C28H30F3N5O/c1-34-9-11-35(12-10-34)18-20-13-24(28(29,30)31)16-25(14-20)33-27(37)22-5-4-21-6-8-36(19-23(21)15-22)26-3-2-7-32-17-26/h2-5,7,13-17H,6,8-12,18-19H2,1H3,(H,33,37)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410060
PNG
(D2190 | US10370360, Example 12)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1ccc(CN2CCN(C)CC2)c(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C28H31F3N6O/c1-19-15-37(24-13-32-18-33-14-24)17-22-11-20(4-6-25(19)22)27(38)34-23-5-3-21(26(12-23)28(29,30)31)16-36-9-7-35(2)8-10-36/h3-6,11-14,18-19H,7-10,15-17H2,1-2H3,(H,34,38)
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n/an/a 334n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410084
PNG
(D2212 | US10370360, Example 36)
Show SMILES CN1CCN(Cc2cc(cc(c2)C(F)(F)F)C(=O)Nc2ccc3CCN(Cc3c2)c2cncnc2)CC1
Show InChI InChI=1S/C27H29F3N6O/c1-34-6-8-35(9-7-34)16-19-10-21(12-23(11-19)27(28,29)30)26(37)33-24-3-2-20-4-5-36(17-22(20)13-24)25-14-31-18-32-15-25/h2-3,10-15,18H,4-9,16-17H2,1H3,(H,33,37)
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n/an/a 354n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410074
PNG
(D2202 | US10370360, Example 26)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(cc(c1)C(F)(F)F)-n1cnc(C)c1)c1cncnc1
Show InChI InChI=1S/C26H23F3N6O/c1-16-11-34(23-9-30-14-31-10-23)13-19-5-18(3-4-24(16)19)25(36)33-21-6-20(26(27,28)29)7-22(8-21)35-12-17(2)32-15-35/h3-10,12,14-16H,11,13H2,1-2H3,(H,33,36)
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n/an/a 432n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM50260024
PNG
(CHEMBL4095191 | US10370360, Example 3)
Show SMILES CN1CCN(Cc2cc(NC(=O)c3ccc4CCN(Cc4c3)c3cncnc3)cc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C27H29F3N6O/c1-34-6-8-35(9-7-34)16-19-10-23(27(28,29)30)13-24(11-19)33-26(37)21-3-2-20-4-5-36(17-22(20)12-21)25-14-31-18-32-15-25/h2-3,10-15,18H,4-9,16-17H2,1H3,(H,33,37)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410050
PNG
(D2217 | US10370360, Example 2)
Show SMILES CC1CN(Cc2cc(NC(=O)c3cc(CN4CCN(C)CC4)cc(c3)C(F)(F)F)ccc12)c1cncnc1
Show InChI InChI=1S/C28H31F3N6O/c1-19-15-37(25-13-32-18-33-14-25)17-22-12-24(3-4-26(19)22)34-27(38)21-9-20(10-23(11-21)28(29,30)31)16-36-7-5-35(2)6-8-36/h3-4,9-14,18-19H,5-8,15-17H2,1-2H3,(H,34,38)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410058
PNG
(D2276 | US10370360, Example 10)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CCN2CCN(C)CC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C29H33F3N6O/c1-20-17-38(26-15-33-19-34-16-26)18-23-13-22(3-4-27(20)23)28(39)35-25-12-21(11-24(14-25)29(30,31)32)5-6-37-9-7-36(2)8-10-37/h3-4,11-16,19-20H,5-10,17-18H2,1-2H3,(H,35,39)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410070
PNG
(D2215 | US10370360, Example 22)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C1CCCCC1)c1cncnc1
Show InChI InChI=1S/C33H42N6O/c1-24-20-39(31-18-34-23-35-19-31)22-29-16-27(8-9-32(24)29)33(40)36-30-15-25(21-38-12-10-37(2)11-13-38)14-28(17-30)26-6-4-3-5-7-26/h8-9,14-19,23-24,26H,3-7,10-13,20-22H2,1-2H3,(H,36,40)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM50260033
PNG
(CHEMBL4066114 | US10370360, Example 38)
Show SMILES C[C@H]1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C28H31F3N6O/c1-19-15-37(25-13-32-18-33-14-25)17-22-11-21(3-4-26(19)22)27(38)34-24-10-20(9-23(12-24)28(29,30)31)16-36-7-5-35(2)6-8-36/h3-4,9-14,18-19H,5-8,15-17H2,1-2H3,(H,34,38)/t19-/m0/s1
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410065
PNG
(D2275 | US10370360, Example 17)
Show SMILES CCN1CCN(Cc2cc(NC(=O)c3ccc4C(C)CN(Cc4c3)c3cncnc3)cc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C29H33F3N6O/c1-3-36-6-8-37(9-7-36)17-21-10-24(29(30,31)32)13-25(11-21)35-28(39)22-4-5-27-20(2)16-38(18-23(27)12-22)26-14-33-19-34-15-26/h4-5,10-15,19-20H,3,6-9,16-18H2,1-2H3,(H,35,39)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410078
PNG
(D2574 | US10370360, Example 30)
Show SMILES CC1Cc2ccc(cc2CN1c1cncnc1)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H31F3N6O/c1-19-9-21-3-4-22(12-23(21)17-37(19)26-14-32-18-33-15-26)27(38)34-25-11-20(10-24(13-25)28(29,30)31)16-36-7-5-35(2)6-8-36/h3-4,10-15,18-19H,5-9,16-17H2,1-2H3,(H,34,38)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410060
PNG
(D2190 | US10370360, Example 12)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1ccc(CN2CCN(C)CC2)c(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C28H31F3N6O/c1-19-15-37(24-13-32-18-33-14-24)17-22-11-20(4-6-25(19)22)27(38)34-23-5-3-21(26(12-23)28(29,30)31)16-36-9-7-35(2)8-10-36/h3-6,11-14,18-19H,7-10,15-17H2,1-2H3,(H,34,38)
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n/an/a 546n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM410053
PNG
(D2568 | US10370360, Example 5)
Show SMILES CN1CCN(Cc2cc(NC(=O)c3ccc4CCN(Cc4c3)c3cnc4ccccc4c3)cc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C32H32F3N5O/c1-38-10-12-39(13-11-38)20-22-14-27(32(33,34)35)18-28(15-22)37-31(41)25-7-6-23-8-9-40(21-26(23)16-25)29-17-24-4-2-3-5-30(24)36-19-29/h2-7,14-19H,8-13,20-21H2,1H3,(H,37,41)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410062
PNG
(D2197 | US10370360, Example 14)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCCN(C)CC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C29H33F3N6O/c1-20-16-38(26-14-33-19-34-15-26)18-23-12-22(4-5-27(20)23)28(39)35-25-11-21(10-24(13-25)29(30,31)32)17-37-7-3-6-36(2)8-9-37/h4-5,10-15,19-20H,3,6-9,16-18H2,1-2H3,(H,35,39)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (DDR1)


(Homo sapiens (Human))
BDBM50260011
PNG
(CHEMBL4060157 | US10370360, Example 39)
Show SMILES C[C@@H]1CN(Cc2cc(NC(=O)c3cc(CN4CCN(C)CC4)cc(c3)C(F)(F)F)ccc12)c1cncnc1
Show InChI InChI=1S/C28H31F3N6O/c1-19-15-37(25-13-32-18-33-14-25)17-22-12-24(3-4-26(19)22)34-27(38)21-9-20(10-23(11-21)28(29,30)31)16-36-7-5-35(2)6-8-36/h3-4,9-14,18-19H,5-8,15-17H2,1-2H3,(H,34,38)/t19-/m1/s1
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410064
PNG
(D2187 | US10370360, Example 16)
Show SMILES CC(C)c1cc(CN2CCN(C)CC2)cc(NC(=O)c2ccc3C(C)CN(Cc3c2)c2cncnc2)c1
Show InChI InChI=1S/C30H38N6O/c1-21(2)25-11-23(18-35-9-7-34(4)8-10-35)12-27(14-25)33-30(37)24-5-6-29-22(3)17-36(19-26(29)13-24)28-15-31-20-32-16-28/h5-6,11-16,20-22H,7-10,17-19H2,1-4H3,(H,33,37)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM50260024
PNG
(CHEMBL4095191 | US10370360, Example 3)
Show SMILES CN1CCN(Cc2cc(NC(=O)c3ccc4CCN(Cc4c3)c3cncnc3)cc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C27H29F3N6O/c1-34-6-8-35(9-7-34)16-19-10-23(27(28,29)30)13-24(11-19)33-26(37)21-3-2-20-4-5-36(17-22(20)12-21)25-14-31-18-32-15-25/h2-3,10-15,18H,4-9,16-17H2,1H3,(H,33,37)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410072
PNG
(D2473 | US10370360, Example 24)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CC[C@H](C2)N(C)C)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C29H33F3N6O/c1-19-14-38(26-12-33-18-34-13-26)16-22-10-21(4-5-27(19)22)28(39)35-24-9-20(8-23(11-24)29(30,31)32)15-37-7-6-25(17-37)36(2)3/h4-5,8-13,18-19,25H,6-7,14-17H2,1-3H3,(H,35,39)/t19?,25-/m1/s1
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410073
PNG
(D2475 | US10370360, Example 25)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CC[C@@H](C2)N(C)C)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C29H33F3N6O/c1-19-14-38(26-12-33-18-34-13-26)16-22-10-21(4-5-27(19)22)28(39)35-24-9-20(8-23(11-24)29(30,31)32)15-37-7-6-25(17-37)36(2)3/h4-5,8-13,18-19,25H,6-7,14-17H2,1-3H3,(H,35,39)/t19?,25-/m0/s1
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410056
PNG
(D2198 | US10370360, Example 8)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)c(Cl)c(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C28H30ClF3N6O/c1-18-14-38(23-12-33-17-34-13-23)16-20-9-19(3-4-24(18)20)27(39)35-22-10-21(15-37-7-5-36(2)6-8-37)26(29)25(11-22)28(30,31)32/h3-4,9-13,17-18H,5-8,14-16H2,1-2H3,(H,35,39)
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n/an/a 915n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410076
PNG
(D2350 | US10370360, Example 28)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(C)(C)C)c1cncnc1
Show InChI InChI=1S/C31H40N6O/c1-22-18-37(28-16-32-21-33-17-28)20-25-14-24(6-7-29(22)25)30(38)34-27-13-23(12-26(15-27)31(2,3)4)19-36-10-8-35(5)9-11-36/h6-7,12-17,21-22H,8-11,18-20H2,1-5H3,(H,34,38)
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n/an/a 940n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410081
PNG
(D2195 | US10370360, Example 33)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(CC2)C2CCCCC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C33H39F3N6O/c1-23-19-42(30-17-37-22-38-18-30)21-26-15-25(7-8-31(23)26)32(43)39-28-14-24(13-27(16-28)33(34,35)36)20-40-9-11-41(12-10-40)29-5-3-2-4-6-29/h7-8,13-18,22-23,29H,2-6,9-12,19-21H2,1H3,(H,39,43)
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n/an/a 945n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410057
PNG
(D2274 | US10370360, Example 9)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)c(C)c(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C29H33F3N6O/c1-19-15-38(25-13-33-18-34-14-25)17-23-10-21(4-5-26(19)23)28(39)35-24-11-22(16-37-8-6-36(3)7-9-37)20(2)27(12-24)29(30,31)32/h4-5,10-14,18-19H,6-9,15-17H2,1-3H3,(H,35,39)
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n/an/a 1.10E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410079
PNG
(D2347 | US10370360, Example 31)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C1CC1)c1cncnc1
Show InChI InChI=1S/C30H36N6O/c1-21-17-36(28-15-31-20-32-16-28)19-26-13-24(5-6-29(21)26)30(37)33-27-12-22(11-25(14-27)23-3-4-23)18-35-9-7-34(2)8-10-35/h5-6,11-16,20-21,23H,3-4,7-10,17-19H2,1-2H3,(H,33,37)
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n/an/a 1.10E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410071
PNG
(D2474 | US10370360, Example 23)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN(C)CCN(C)C)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C28H33F3N6O/c1-19-15-37(25-13-32-18-33-14-25)17-22-11-21(5-6-26(19)22)27(38)34-24-10-20(9-23(12-24)28(29,30)31)16-36(4)8-7-35(2)3/h5-6,9-14,18-19H,7-8,15-17H2,1-4H3,(H,34,38)
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n/an/a 1.20E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410054
PNG
(D2103 | US10370360, Example 6)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F)c1cccnc1
Show InChI InChI=1S/C29H32F3N5O/c1-20-17-37(26-4-3-7-33-16-26)19-23-14-22(5-6-27(20)23)28(38)34-25-13-21(12-24(15-25)29(30,31)32)18-36-10-8-35(2)9-11-36/h3-7,12-16,20H,8-11,17-19H2,1-2H3,(H,34,38)
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n/an/a 1.20E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410050
PNG
(D2217 | US10370360, Example 2)
Show SMILES CC1CN(Cc2cc(NC(=O)c3cc(CN4CCN(C)CC4)cc(c3)C(F)(F)F)ccc12)c1cncnc1
Show InChI InChI=1S/C28H31F3N6O/c1-19-15-37(25-13-32-18-33-14-25)17-22-12-24(3-4-26(19)22)34-27(38)21-9-20(10-23(11-21)28(29,30)31)16-36-7-5-35(2)6-8-36/h3-4,9-14,18-19H,5-8,15-17H2,1-2H3,(H,34,38)
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n/an/a 1.40E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410077
PNG
(D2476 | US10370360, Example 29)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)-c1ccccc1)c1cncnc1
Show InChI InChI=1S/C33H36N6O/c1-24-20-39(31-18-34-23-35-19-31)22-29-16-27(8-9-32(24)29)33(40)36-30-15-25(21-38-12-10-37(2)11-13-38)14-28(17-30)26-6-4-3-5-7-26/h3-9,14-19,23-24H,10-13,20-22H2,1-2H3,(H,36,40)
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n/an/a 1.40E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410075
PNG
(D2214 | US10370360, Example 27)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)c(F)c(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C28H30F4N6O/c1-18-14-38(23-12-33-17-34-13-23)16-20-9-19(3-4-24(18)20)27(39)35-22-10-21(15-37-7-5-36(2)6-8-37)26(29)25(11-22)28(30,31)32/h3-4,9-13,17-18H,5-8,14-16H2,1-2H3,(H,35,39)
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n/an/a 1.40E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410063
PNG
(D2193 | US10370360, Example 15)
Show SMILES CCc1cc(CN2CCN(C)CC2)cc(NC(=O)c2ccc3C(C)CN(Cc3c2)c2cncnc2)c1
Show InChI InChI=1S/C29H36N6O/c1-4-22-11-23(18-34-9-7-33(3)8-10-34)13-26(12-22)32-29(36)24-5-6-28-21(2)17-35(19-25(28)14-24)27-15-30-20-31-16-27/h5-6,11-16,20-21H,4,7-10,17-19H2,1-3H3,(H,32,36)
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n/an/a 1.40E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM50260029
PNG
(CHEMBL4088388 | US10370360, Example 40)
Show SMILES C[C@H]1CN(Cc2cc(NC(=O)c3cc(CN4CCN(C)CC4)cc(c3)C(F)(F)F)ccc12)c1cncnc1
Show InChI InChI=1S/C28H31F3N6O/c1-19-15-37(25-13-32-18-33-14-25)17-22-12-24(3-4-26(19)22)34-27(38)21-9-20(10-23(11-21)28(29,30)31)16-36-7-5-35(2)6-8-36/h3-4,9-14,18-19H,5-8,15-17H2,1-2H3,(H,34,38)/t19-/m0/s1
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US Patent
n/an/a 1.40E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410049
PNG
(D2095 | US10370360, Example 1)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C28H31F3N6O/c1-19-15-37(25-13-32-18-33-14-25)17-22-11-21(3-4-26(19)22)27(38)34-24-10-20(9-23(12-24)28(29,30)31)16-36-7-5-35(2)6-8-36/h3-4,9-14,18-19H,5-8,15-17H2,1-2H3,(H,34,38)
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n/an/a 1.80E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410082
PNG
(D2213 | US10370360, Example 34)
Show SMILES CCC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C29H33F3N6O/c1-3-21-17-38(26-14-33-19-34-15-26)18-23-12-22(4-5-27(21)23)28(39)35-25-11-20(10-24(13-25)29(30,31)32)16-37-8-6-36(2)7-9-37/h4-5,10-15,19,21H,3,6-9,16-18H2,1-2H3,(H,35,39)
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n/an/a 2.00E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410049
PNG
(D2095 | US10370360, Example 1)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C28H31F3N6O/c1-19-15-37(25-13-32-18-33-14-25)17-22-11-21(3-4-26(19)22)27(38)34-24-10-20(9-23(12-24)28(29,30)31)16-36-7-5-35(2)6-8-36/h3-4,9-14,18-19H,5-8,15-17H2,1-2H3,(H,34,38)
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n/an/a 2.10E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410067
PNG
(D2194 | US10370360, Example 19)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCCCC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C28H30F3N5O/c1-19-15-36(25-13-32-18-33-14-25)17-22-11-21(5-6-26(19)22)27(37)34-24-10-20(9-23(12-24)28(29,30)31)16-35-7-3-2-4-8-35/h5-6,9-14,18-19H,2-4,7-8,15-17H2,1H3,(H,34,37)
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n/an/a 2.20E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410059
PNG
(D2188 | US10370360, Example 11)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(cc(c1)C(F)(F)F)N1CCN(C)CC1)c1cncnc1
Show InChI InChI=1S/C27H29F3N6O/c1-18-15-36(24-13-31-17-32-14-24)16-20-9-19(3-4-25(18)20)26(37)33-22-10-21(27(28,29)30)11-23(12-22)35-7-5-34(2)6-8-35/h3-4,9-14,17-18H,5-8,15-16H2,1-2H3,(H,33,37)
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n/an/a 2.20E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410068
PNG
(D2573 | US10370360, Example 20)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCCC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C27H28F3N5O/c1-18-14-35(24-12-31-17-32-13-24)16-21-10-20(4-5-25(18)21)26(36)33-23-9-19(15-34-6-2-3-7-34)8-22(11-23)27(28,29)30/h4-5,8-13,17-18H,2-3,6-7,14-16H2,1H3,(H,33,36)
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n/an/a 2.30E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410053
PNG
(D2568 | US10370360, Example 5)
Show SMILES CN1CCN(Cc2cc(NC(=O)c3ccc4CCN(Cc4c3)c3cnc4ccccc4c3)cc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C32H32F3N5O/c1-38-10-12-39(13-11-38)20-22-14-27(32(33,34)35)18-28(15-22)37-31(41)25-7-6-23-8-9-40(21-26(23)16-25)29-17-24-4-2-3-5-30(24)36-19-29/h2-7,14-19H,8-13,20-21H2,1H3,(H,37,41)
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n/an/a 3.60E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410083
PNG
(D2191 | US10370360, Example 35)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCSCC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C27H28F3N5OS/c1-18-14-35(24-12-31-17-32-13-24)16-21-10-20(2-3-25(18)21)26(36)33-23-9-19(8-22(11-23)27(28,29)30)15-34-4-6-37-7-5-34/h2-3,8-13,17-18H,4-7,14-16H2,1H3,(H,33,36)
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n/an/a 3.70E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410085
PNG
(D2099 | US10370360, Example 37)
Show SMILES C[C@@H]1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C28H31F3N6O/c1-19-15-37(25-13-32-18-33-14-25)17-22-11-21(3-4-26(19)22)27(38)34-24-10-20(9-23(12-24)28(29,30)31)16-36-7-5-35(2)6-8-36/h3-4,9-14,18-19H,5-8,15-17H2,1-2H3,(H,34,38)/t19-/m1/s1
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n/an/a 4.20E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410076
PNG
(D2350 | US10370360, Example 28)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(C)(C)C)c1cncnc1
Show InChI InChI=1S/C31H40N6O/c1-22-18-37(28-16-32-21-33-17-28)20-25-14-24(6-7-29(22)25)30(38)34-27-13-23(12-26(15-27)31(2,3)4)19-36-10-8-35(5)9-11-36/h6-7,12-17,21-22H,8-11,18-20H2,1-5H3,(H,34,38)
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n/an/a 4.30E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410052
PNG
(D2211 | US10370360, Example 4)
Show SMILES CN1CCN(Cc2cc(NC(=O)c3ccc4CCN(Cc4c3)c3cccnc3)cc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C28H30F3N5O/c1-34-9-11-35(12-10-34)18-20-13-24(28(29,30)31)16-25(14-20)33-27(37)22-5-4-21-6-8-36(19-23(21)15-22)26-3-2-7-32-17-26/h2-5,7,13-17H,6,8-12,18-19H2,1H3,(H,33,37)
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n/an/a 4.30E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410053
PNG
(D2568 | US10370360, Example 5)
Show SMILES CN1CCN(Cc2cc(NC(=O)c3ccc4CCN(Cc4c3)c3cnc4ccccc4c3)cc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C32H32F3N5O/c1-38-10-12-39(13-11-38)20-22-14-27(32(33,34)35)18-28(15-22)37-31(41)25-7-6-23-8-9-40(21-26(23)16-25)29-17-24-4-2-3-5-30(24)36-19-29/h2-7,14-19H,8-13,20-21H2,1H3,(H,37,41)
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n/an/a 4.50E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410066
PNG
(D2201 | US10370360, Example 18)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCOCC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C27H28F3N5O2/c1-18-14-35(24-12-31-17-32-13-24)16-21-10-20(2-3-25(18)21)26(36)33-23-9-19(8-22(11-23)27(28,29)30)15-34-4-6-37-7-5-34/h2-3,8-13,17-18H,4-7,14-16H2,1H3,(H,33,36)
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n/an/a 4.50E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM50260028
PNG
(CHEMBL4068810 | US10370360, Example 7)
Show SMILES CN1CCN(Cc2cc(NC(=O)c3ccc4c(CN(CC4(C)C)c4cncnc4)c3)cc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C29H33F3N6O/c1-28(2)18-38(25-14-33-19-34-15-25)17-22-12-21(4-5-26(22)28)27(39)35-24-11-20(10-23(13-24)29(30,31)32)16-37-8-6-36(3)7-9-37/h4-5,10-15,19H,6-9,16-18H2,1-3H3,(H,35,39)
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US Patent
n/an/a 4.50E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410080
PNG
(D2196 | US10370360, Example 32)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C1CCCC1)c1cncnc1
Show InChI InChI=1S/C32H40N6O/c1-23-19-38(30-17-33-22-34-18-30)21-28-15-26(7-8-31(23)28)32(39)35-29-14-24(20-37-11-9-36(2)10-12-37)13-27(16-29)25-5-3-4-6-25/h7-8,13-18,22-23,25H,3-6,9-12,19-21H2,1-2H3,(H,35,39)
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n/an/a 4.80E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410050
PNG
(D2217 | US10370360, Example 2)
Show SMILES CC1CN(Cc2cc(NC(=O)c3cc(CN4CCN(C)CC4)cc(c3)C(F)(F)F)ccc12)c1cncnc1
Show InChI InChI=1S/C28H31F3N6O/c1-19-15-37(25-13-32-18-33-14-25)17-22-12-24(3-4-26(19)22)34-27(38)21-9-20(10-23(11-21)28(29,30)31)16-36-7-5-35(2)6-8-36/h3-4,9-14,18-19H,5-8,15-17H2,1-2H3,(H,34,38)
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n/an/a 5.80E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410054
PNG
(D2103 | US10370360, Example 6)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F)c1cccnc1
Show InChI InChI=1S/C29H32F3N5O/c1-20-17-37(26-4-3-7-33-16-26)19-23-14-22(5-6-27(20)23)28(38)34-25-13-21(12-24(15-25)29(30,31)32)18-36-10-8-35(2)9-11-36/h3-7,12-16,20H,8-11,17-19H2,1-2H3,(H,34,38)
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n/an/a 6.10E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410069
PNG
(D2192 | US10370360, Example 21)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN(C)C)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C25H26F3N5O/c1-16-12-33(22-10-29-15-30-11-22)14-19-8-18(4-5-23(16)19)24(34)31-21-7-17(13-32(2)3)6-20(9-21)25(26,27)28/h4-11,15-16H,12-14H2,1-3H3,(H,31,34)
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n/an/a 6.70E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410072
PNG
(D2473 | US10370360, Example 24)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CC[C@H](C2)N(C)C)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C29H33F3N6O/c1-19-14-38(26-12-33-18-34-13-26)16-22-10-21(4-5-27(19)22)28(39)35-24-9-20(8-23(11-24)29(30,31)32)15-37-7-6-25(17-37)36(2)3/h4-5,8-13,18-19,25H,6-7,14-17H2,1-3H3,(H,35,39)/t19?,25-/m1/s1
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n/an/a 6.70E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410074
PNG
(D2202 | US10370360, Example 26)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(cc(c1)C(F)(F)F)-n1cnc(C)c1)c1cncnc1
Show InChI InChI=1S/C26H23F3N6O/c1-16-11-34(23-9-30-14-31-10-23)13-19-5-18(3-4-24(16)19)25(36)33-21-6-20(26(27,28)29)7-22(8-21)35-12-17(2)32-15-35/h3-10,12,14-16H,11,13H2,1-2H3,(H,33,36)
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n/an/a 7.20E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410064
PNG
(D2187 | US10370360, Example 16)
Show SMILES CC(C)c1cc(CN2CCN(C)CC2)cc(NC(=O)c2ccc3C(C)CN(Cc3c2)c2cncnc2)c1
Show InChI InChI=1S/C30H38N6O/c1-21(2)25-11-23(18-35-9-7-34(4)8-10-35)12-27(14-25)33-30(37)24-5-6-29-22(3)17-36(19-26(29)13-24)28-15-31-20-32-16-28/h5-6,11-16,20-22H,7-10,17-19H2,1-4H3,(H,33,37)
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n/an/a 7.20E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410078
PNG
(D2574 | US10370360, Example 30)
Show SMILES CC1Cc2ccc(cc2CN1c1cncnc1)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H31F3N6O/c1-19-9-21-3-4-22(12-23(21)17-37(19)26-14-32-18-33-15-26)27(38)34-25-11-20(10-24(13-25)28(29,30)31)16-36-7-5-35(2)6-8-36/h3-4,10-15,18-19H,5-9,16-17H2,1-2H3,(H,34,38)
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n/an/a 7.60E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410084
PNG
(D2212 | US10370360, Example 36)
Show SMILES CN1CCN(Cc2cc(cc(c2)C(F)(F)F)C(=O)Nc2ccc3CCN(Cc3c2)c2cncnc2)CC1
Show InChI InChI=1S/C27H29F3N6O/c1-34-6-8-35(9-7-34)16-19-10-21(12-23(11-19)27(28,29)30)26(37)33-24-3-2-20-4-5-36(17-22(20)13-24)25-14-31-18-32-15-25/h2-3,10-15,18H,4-9,16-17H2,1H3,(H,33,37)
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n/an/a 7.80E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM50260024
PNG
(CHEMBL4095191 | US10370360, Example 3)
Show SMILES CN1CCN(Cc2cc(NC(=O)c3ccc4CCN(Cc4c3)c3cncnc3)cc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C27H29F3N6O/c1-34-6-8-35(9-7-34)16-19-10-23(27(28,29)30)13-24(11-19)33-26(37)21-3-2-20-4-5-36(17-22(20)12-21)25-14-31-18-32-15-25/h2-3,10-15,18H,4-9,16-17H2,1H3,(H,33,37)
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n/an/a 8.00E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410053
PNG
(D2568 | US10370360, Example 5)
Show SMILES CN1CCN(Cc2cc(NC(=O)c3ccc4CCN(Cc4c3)c3cnc4ccccc4c3)cc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C32H32F3N5O/c1-38-10-12-39(13-11-38)20-22-14-27(32(33,34)35)18-28(15-22)37-31(41)25-7-6-23-8-9-40(21-26(23)16-25)29-17-24-4-2-3-5-30(24)36-19-29/h2-7,14-19H,8-13,20-21H2,1H3,(H,37,41)
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n/an/a 8.70E+3n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410056
PNG
(D2198 | US10370360, Example 8)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)c(Cl)c(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C28H30ClF3N6O/c1-18-14-38(23-12-33-17-34-13-23)16-20-9-19(3-4-24(18)20)27(39)35-22-10-21(15-37-7-5-36(2)6-8-37)26(29)25(11-22)28(30,31)32/h3-4,9-13,17-18H,5-8,14-16H2,1-2H3,(H,35,39)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410066
PNG
(D2201 | US10370360, Example 18)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCOCC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C27H28F3N5O2/c1-18-14-35(24-12-31-17-32-13-24)16-21-10-20(2-3-25(18)21)26(36)33-23-9-19(8-22(11-23)27(28,29)30)15-34-4-6-37-7-5-34/h2-3,8-13,17-18H,4-7,14-16H2,1H3,(H,33,36)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410072
PNG
(D2473 | US10370360, Example 24)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CC[C@H](C2)N(C)C)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C29H33F3N6O/c1-19-14-38(26-12-33-18-34-13-26)16-22-10-21(4-5-27(19)22)28(39)35-24-9-20(8-23(11-24)29(30,31)32)15-37-7-6-25(17-37)36(2)3/h4-5,8-13,18-19,25H,6-7,14-17H2,1-3H3,(H,35,39)/t19?,25-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410080
PNG
(D2196 | US10370360, Example 32)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C1CCCC1)c1cncnc1
Show InChI InChI=1S/C32H40N6O/c1-23-19-38(30-17-33-22-34-18-30)21-28-15-26(7-8-31(23)28)32(39)35-29-14-24(20-37-11-9-36(2)10-12-37)13-27(16-29)25-5-3-4-6-25/h7-8,13-18,22-23,25H,3-6,9-12,19-21H2,1-2H3,(H,35,39)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410081
PNG
(D2195 | US10370360, Example 33)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(CC2)C2CCCCC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C33H39F3N6O/c1-23-19-42(30-17-37-22-38-18-30)21-26-15-25(7-8-31(23)26)32(43)39-28-14-24(13-27(16-28)33(34,35)36)20-40-9-11-41(12-10-40)29-5-3-2-4-6-29/h7-8,13-18,22-23,29H,2-6,9-12,19-21H2,1H3,(H,39,43)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50260011
PNG
(CHEMBL4060157 | US10370360, Example 39)
Show SMILES C[C@@H]1CN(Cc2cc(NC(=O)c3cc(CN4CCN(C)CC4)cc(c3)C(F)(F)F)ccc12)c1cncnc1
Show InChI InChI=1S/C28H31F3N6O/c1-19-15-37(25-13-32-18-33-14-25)17-22-12-24(3-4-26(19)22)34-27(38)21-9-20(10-23(11-21)28(29,30)31)16-36-7-5-35(2)6-8-36/h3-4,9-14,18-19H,5-8,15-17H2,1-2H3,(H,34,38)/t19-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410058
PNG
(D2276 | US10370360, Example 10)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CCN2CCN(C)CC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C29H33F3N6O/c1-20-17-38(26-15-33-19-34-16-26)18-23-13-22(3-4-27(20)23)28(39)35-25-12-21(11-24(14-25)29(30,31)32)5-6-37-9-7-36(2)8-10-37/h3-4,11-16,19-20H,5-10,17-18H2,1-2H3,(H,35,39)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410062
PNG
(D2197 | US10370360, Example 14)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCCN(C)CC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C29H33F3N6O/c1-20-16-38(26-14-33-19-34-15-26)18-23-12-22(4-5-27(20)23)28(39)35-25-11-21(10-24(13-25)29(30,31)32)17-37-7-3-6-36(2)8-9-37/h4-5,10-15,19-20H,3,6-9,16-18H2,1-2H3,(H,35,39)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410067
PNG
(D2194 | US10370360, Example 19)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCCCC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C28H30F3N5O/c1-19-15-36(25-13-32-18-33-14-25)17-22-11-21(5-6-26(19)22)27(37)34-24-10-20(9-23(12-24)28(29,30)31)16-35-7-3-2-4-8-35/h5-6,9-14,18-19H,2-4,7-8,15-17H2,1H3,(H,34,37)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410068
PNG
(D2573 | US10370360, Example 20)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCCC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C27H28F3N5O/c1-18-14-35(24-12-31-17-32-13-24)16-21-10-20(4-5-25(18)21)26(36)33-23-9-19(15-34-6-2-3-7-34)8-22(11-23)27(28,29)30/h4-5,8-13,17-18H,2-3,6-7,14-16H2,1H3,(H,33,36)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410070
PNG
(D2215 | US10370360, Example 22)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C1CCCCC1)c1cncnc1
Show InChI InChI=1S/C33H42N6O/c1-24-20-39(31-18-34-23-35-19-31)22-29-16-27(8-9-32(24)29)33(40)36-30-15-25(21-38-12-10-37(2)11-13-38)14-28(17-30)26-6-4-3-5-7-26/h8-9,14-19,23-24,26H,3-7,10-13,20-22H2,1-2H3,(H,36,40)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410071
PNG
(D2474 | US10370360, Example 23)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN(C)CCN(C)C)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C28H33F3N6O/c1-19-15-37(25-13-32-18-33-14-25)17-22-11-21(5-6-26(19)22)27(38)34-24-10-20(9-23(12-24)28(29,30)31)16-36(4)8-7-35(2)3/h5-6,9-14,18-19H,7-8,15-17H2,1-4H3,(H,34,38)
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n/an/a 1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM50260011
PNG
(CHEMBL4060157 | US10370360, Example 39)
Show SMILES C[C@@H]1CN(Cc2cc(NC(=O)c3cc(CN4CCN(C)CC4)cc(c3)C(F)(F)F)ccc12)c1cncnc1
Show InChI InChI=1S/C28H31F3N6O/c1-19-15-37(25-13-32-18-33-14-25)17-22-12-24(3-4-26(19)22)34-27(38)21-9-20(10-23(11-21)28(29,30)31)16-36-7-5-35(2)6-8-36/h3-4,9-14,18-19H,5-8,15-17H2,1-2H3,(H,34,38)/t19-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410054
PNG
(D2103 | US10370360, Example 6)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F)c1cccnc1
Show InChI InChI=1S/C29H32F3N5O/c1-20-17-37(26-4-3-7-33-16-26)19-23-14-22(5-6-27(20)23)28(38)34-25-13-21(12-24(15-25)29(30,31)32)18-36-10-8-35(2)9-11-36/h3-7,12-16,20H,8-11,17-19H2,1-2H3,(H,34,38)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410059
PNG
(D2188 | US10370360, Example 11)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(cc(c1)C(F)(F)F)N1CCN(C)CC1)c1cncnc1
Show InChI InChI=1S/C27H29F3N6O/c1-18-15-36(24-13-31-17-32-14-24)16-20-9-19(3-4-25(18)20)26(37)33-22-10-21(27(28,29)30)11-23(12-22)35-7-5-34(2)6-8-35/h3-4,9-14,17-18H,5-8,15-16H2,1-2H3,(H,33,37)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410065
PNG
(D2275 | US10370360, Example 17)
Show SMILES CCN1CCN(Cc2cc(NC(=O)c3ccc4C(C)CN(Cc4c3)c3cncnc3)cc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C29H33F3N6O/c1-3-36-6-8-37(9-7-36)17-21-10-24(29(30,31)32)13-25(11-21)35-28(39)22-4-5-27-20(2)16-38(18-23(27)12-22)26-14-33-19-34-15-26/h4-5,10-15,19-20H,3,6-9,16-18H2,1-2H3,(H,35,39)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410065
PNG
(D2275 | US10370360, Example 17)
Show SMILES CCN1CCN(Cc2cc(NC(=O)c3ccc4C(C)CN(Cc4c3)c3cncnc3)cc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C29H33F3N6O/c1-3-36-6-8-37(9-7-36)17-21-10-24(29(30,31)32)13-25(11-21)35-28(39)22-4-5-27-20(2)16-38(18-23(27)12-22)26-14-33-19-34-15-26/h4-5,10-15,19-20H,3,6-9,16-18H2,1-2H3,(H,35,39)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410073
PNG
(D2475 | US10370360, Example 25)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CC[C@@H](C2)N(C)C)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C29H33F3N6O/c1-19-14-38(26-12-33-18-34-13-26)16-22-10-21(4-5-27(19)22)28(39)35-24-9-20(8-23(11-24)29(30,31)32)15-37-7-6-25(17-37)36(2)3/h4-5,8-13,18-19,25H,6-7,14-17H2,1-3H3,(H,35,39)/t19?,25-/m0/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410075
PNG
(D2214 | US10370360, Example 27)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)c(F)c(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C28H30F4N6O/c1-18-14-38(23-12-33-17-34-13-23)16-20-9-19(3-4-24(18)20)27(39)35-22-10-21(15-37-7-5-36(2)6-8-37)26(29)25(11-22)28(30,31)32/h3-4,9-13,17-18H,5-8,14-16H2,1-2H3,(H,35,39)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410078
PNG
(D2574 | US10370360, Example 30)
Show SMILES CC1Cc2ccc(cc2CN1c1cncnc1)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H31F3N6O/c1-19-9-21-3-4-22(12-23(21)17-37(19)26-14-32-18-33-15-26)27(38)34-25-11-20(10-24(13-25)28(29,30)31)16-36-7-5-35(2)6-8-36/h3-4,10-15,18-19H,5-9,16-17H2,1-2H3,(H,34,38)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410085
PNG
(D2099 | US10370360, Example 37)
Show SMILES C[C@@H]1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C28H31F3N6O/c1-19-15-37(25-13-32-18-33-14-25)17-22-11-21(3-4-26(19)22)27(38)34-24-10-20(9-23(12-24)28(29,30)31)16-36-7-5-35(2)6-8-36/h3-4,9-14,18-19H,5-8,15-17H2,1-2H3,(H,34,38)/t19-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM50260011
PNG
(CHEMBL4060157 | US10370360, Example 39)
Show SMILES C[C@@H]1CN(Cc2cc(NC(=O)c3cc(CN4CCN(C)CC4)cc(c3)C(F)(F)F)ccc12)c1cncnc1
Show InChI InChI=1S/C28H31F3N6O/c1-19-15-37(25-13-32-18-33-14-25)17-22-12-24(3-4-26(19)22)34-27(38)21-9-20(10-23(11-21)28(29,30)31)16-36-7-5-35(2)6-8-36/h3-4,9-14,18-19H,5-8,15-17H2,1-2H3,(H,34,38)/t19-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50260029
PNG
(CHEMBL4088388 | US10370360, Example 40)
Show SMILES C[C@H]1CN(Cc2cc(NC(=O)c3cc(CN4CCN(C)CC4)cc(c3)C(F)(F)F)ccc12)c1cncnc1
Show InChI InChI=1S/C28H31F3N6O/c1-19-15-37(25-13-32-18-33-14-25)17-22-12-24(3-4-26(19)22)34-27(38)21-9-20(10-23(11-21)28(29,30)31)16-36-7-5-35(2)6-8-36/h3-4,9-14,18-19H,5-8,15-17H2,1-2H3,(H,34,38)/t19-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410049
PNG
(D2095 | US10370360, Example 1)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C28H31F3N6O/c1-19-15-37(25-13-32-18-33-14-25)17-22-11-21(3-4-26(19)22)27(38)34-24-10-20(9-23(12-24)28(29,30)31)16-36-7-5-35(2)6-8-36/h3-4,9-14,18-19H,5-8,15-17H2,1-2H3,(H,34,38)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410052
PNG
(D2211 | US10370360, Example 4)
Show SMILES CN1CCN(Cc2cc(NC(=O)c3ccc4CCN(Cc4c3)c3cccnc3)cc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C28H30F3N5O/c1-34-9-11-35(12-10-34)18-20-13-24(28(29,30)31)16-25(14-20)33-27(37)22-5-4-21-6-8-36(19-23(21)15-22)26-3-2-7-32-17-26/h2-5,7,13-17H,6,8-12,18-19H2,1H3,(H,33,37)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410057
PNG
(D2274 | US10370360, Example 9)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)c(C)c(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C29H33F3N6O/c1-19-15-38(25-13-33-18-34-14-25)17-23-10-21(4-5-26(19)23)28(39)35-24-11-22(16-37-8-6-36(3)7-9-37)20(2)27(12-24)29(30,31)32/h4-5,10-14,18-19H,6-9,15-17H2,1-3H3,(H,35,39)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410069
PNG
(D2192 | US10370360, Example 21)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN(C)C)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C25H26F3N5O/c1-16-12-33(22-10-29-15-30-11-22)14-19-8-18(4-5-23(16)19)24(34)31-21-7-17(13-32(2)3)6-20(9-21)25(26,27)28/h4-11,15-16H,12-14H2,1-3H3,(H,31,34)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410079
PNG
(D2347 | US10370360, Example 31)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C1CC1)c1cncnc1
Show InChI InChI=1S/C30H36N6O/c1-21-17-36(28-15-31-20-32-16-28)19-26-13-24(5-6-29(21)26)30(37)33-27-12-22(11-25(14-27)23-3-4-23)18-35-9-7-34(2)8-10-35/h5-6,11-16,20-21,23H,3-4,7-10,17-19H2,1-2H3,(H,33,37)
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n/an/a 1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410083
PNG
(D2191 | US10370360, Example 35)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCSCC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C27H28F3N5OS/c1-18-14-35(24-12-31-17-32-13-24)16-21-10-20(2-3-25(18)21)26(36)33-23-9-19(8-22(11-23)27(28,29)30)15-34-4-6-37-7-5-34/h2-3,8-13,17-18H,4-7,14-16H2,1H3,(H,33,36)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410050
PNG
(D2217 | US10370360, Example 2)
Show SMILES CC1CN(Cc2cc(NC(=O)c3cc(CN4CCN(C)CC4)cc(c3)C(F)(F)F)ccc12)c1cncnc1
Show InChI InChI=1S/C28H31F3N6O/c1-19-15-37(25-13-32-18-33-14-25)17-22-12-24(3-4-26(19)22)34-27(38)21-9-20(10-23(11-21)28(29,30)31)16-36-7-5-35(2)6-8-36/h3-4,9-14,18-19H,5-8,15-17H2,1-2H3,(H,34,38)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410061
PNG
(D2199 | US10370360, Example 13)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cccc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C22H19F3N4O/c1-14-11-29(19-9-26-13-27-10-19)12-16-7-15(5-6-20(14)16)21(30)28-18-4-2-3-17(8-18)22(23,24)25/h2-10,13-14H,11-12H2,1H3,(H,28,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410062
PNG
(D2197 | US10370360, Example 14)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCCN(C)CC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C29H33F3N6O/c1-20-16-38(26-14-33-19-34-15-26)18-23-12-22(4-5-27(20)23)28(39)35-25-11-21(10-24(13-25)29(30,31)32)17-37-7-3-6-36(2)8-9-37/h4-5,10-15,19-20H,3,6-9,16-18H2,1-2H3,(H,35,39)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410063
PNG
(D2193 | US10370360, Example 15)
Show SMILES CCc1cc(CN2CCN(C)CC2)cc(NC(=O)c2ccc3C(C)CN(Cc3c2)c2cncnc2)c1
Show InChI InChI=1S/C29H36N6O/c1-4-22-11-23(18-34-9-7-33(3)8-10-34)13-26(12-22)32-29(36)24-5-6-28-21(2)17-35(19-25(28)14-24)27-15-30-20-31-16-27/h5-6,11-16,20-21H,4,7-10,17-19H2,1-3H3,(H,32,36)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410071
PNG
(D2474 | US10370360, Example 23)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN(C)CCN(C)C)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C28H33F3N6O/c1-19-15-37(25-13-32-18-33-14-25)17-22-11-21(5-6-26(19)22)27(38)34-24-10-20(9-23(12-24)28(29,30)31)16-36(4)8-7-35(2)3/h5-6,9-14,18-19H,7-8,15-17H2,1-4H3,(H,34,38)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410077
PNG
(D2476 | US10370360, Example 29)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)-c1ccccc1)c1cncnc1
Show InChI InChI=1S/C33H36N6O/c1-24-20-39(31-18-34-23-35-19-31)22-29-16-27(8-9-32(24)29)33(40)36-30-15-25(21-38-12-10-37(2)11-13-38)14-28(17-30)26-6-4-3-5-7-26/h3-9,14-19,23-24H,10-13,20-22H2,1-2H3,(H,36,40)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410082
PNG
(D2213 | US10370360, Example 34)
Show SMILES CCC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C29H33F3N6O/c1-3-21-17-38(26-14-33-19-34-15-26)18-23-12-22(4-5-27(21)23)28(39)35-25-11-20(10-24(13-25)29(30,31)32)16-37-8-6-36(2)7-9-37/h4-5,10-15,19,21H,3,6-9,16-18H2,1-2H3,(H,35,39)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410085
PNG
(D2099 | US10370360, Example 37)
Show SMILES C[C@@H]1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C28H31F3N6O/c1-19-15-37(25-13-32-18-33-14-25)17-22-11-21(3-4-26(19)22)27(38)34-24-10-20(9-23(12-24)28(29,30)31)16-36-7-5-35(2)6-8-36/h3-4,9-14,18-19H,5-8,15-17H2,1-2H3,(H,34,38)/t19-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410052
PNG
(D2211 | US10370360, Example 4)
Show SMILES CN1CCN(Cc2cc(NC(=O)c3ccc4CCN(Cc4c3)c3cccnc3)cc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C28H30F3N5O/c1-34-9-11-35(12-10-34)18-20-13-24(28(29,30)31)16-25(14-20)33-27(37)22-5-4-21-6-8-36(19-23(21)15-22)26-3-2-7-32-17-26/h2-5,7,13-17H,6,8-12,18-19H2,1H3,(H,33,37)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50260028
PNG
(CHEMBL4068810 | US10370360, Example 7)
Show SMILES CN1CCN(Cc2cc(NC(=O)c3ccc4c(CN(CC4(C)C)c4cncnc4)c3)cc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C29H33F3N6O/c1-28(2)18-38(25-14-33-19-34-15-25)17-22-12-21(4-5-26(22)28)27(39)35-24-11-20(10-23(13-24)29(30,31)32)16-37-8-6-36(3)7-9-37/h4-5,10-15,19H,6-9,16-18H2,1-3H3,(H,35,39)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410056
PNG
(D2198 | US10370360, Example 8)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)c(Cl)c(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C28H30ClF3N6O/c1-18-14-38(23-12-33-17-34-13-23)16-20-9-19(3-4-24(18)20)27(39)35-22-10-21(15-37-7-5-36(2)6-8-37)26(29)25(11-22)28(30,31)32/h3-4,9-13,17-18H,5-8,14-16H2,1-2H3,(H,35,39)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410057
PNG
(D2274 | US10370360, Example 9)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)c(C)c(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C29H33F3N6O/c1-19-15-38(25-13-33-18-34-14-25)17-23-10-21(4-5-26(19)23)28(39)35-24-11-22(16-37-8-6-36(3)7-9-37)20(2)27(12-24)29(30,31)32/h4-5,10-14,18-19H,6-9,15-17H2,1-3H3,(H,35,39)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410058
PNG
(D2276 | US10370360, Example 10)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CCN2CCN(C)CC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C29H33F3N6O/c1-20-17-38(26-15-33-19-34-16-26)18-23-13-22(3-4-27(20)23)28(39)35-25-12-21(11-24(14-25)29(30,31)32)5-6-37-9-7-36(2)8-10-37/h3-4,11-16,19-20H,5-10,17-18H2,1-2H3,(H,35,39)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410059
PNG
(D2188 | US10370360, Example 11)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(cc(c1)C(F)(F)F)N1CCN(C)CC1)c1cncnc1
Show InChI InChI=1S/C27H29F3N6O/c1-18-15-36(24-13-31-17-32-14-24)16-20-9-19(3-4-25(18)20)26(37)33-22-10-21(27(28,29)30)11-23(12-22)35-7-5-34(2)6-8-35/h3-4,9-14,17-18H,5-8,15-16H2,1-2H3,(H,33,37)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410064
PNG
(D2187 | US10370360, Example 16)
Show SMILES CC(C)c1cc(CN2CCN(C)CC2)cc(NC(=O)c2ccc3C(C)CN(Cc3c2)c2cncnc2)c1
Show InChI InChI=1S/C30H38N6O/c1-21(2)25-11-23(18-35-9-7-34(4)8-10-35)12-27(14-25)33-30(37)24-5-6-29-22(3)17-36(19-26(29)13-24)28-15-31-20-32-16-28/h5-6,11-16,20-22H,7-10,17-19H2,1-4H3,(H,33,37)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410068
PNG
(D2573 | US10370360, Example 20)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCCC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C27H28F3N5O/c1-18-14-35(24-12-31-17-32-13-24)16-21-10-20(4-5-25(18)21)26(36)33-23-9-19(15-34-6-2-3-7-34)8-22(11-23)27(28,29)30/h4-5,8-13,17-18H,2-3,6-7,14-16H2,1H3,(H,33,36)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410069
PNG
(D2192 | US10370360, Example 21)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN(C)C)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C25H26F3N5O/c1-16-12-33(22-10-29-15-30-11-22)14-19-8-18(4-5-23(16)19)24(34)31-21-7-17(13-32(2)3)6-20(9-21)25(26,27)28/h4-11,15-16H,12-14H2,1-3H3,(H,31,34)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410070
PNG
(D2215 | US10370360, Example 22)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C1CCCCC1)c1cncnc1
Show InChI InChI=1S/C33H42N6O/c1-24-20-39(31-18-34-23-35-19-31)22-29-16-27(8-9-32(24)29)33(40)36-30-15-25(21-38-12-10-37(2)11-13-38)14-28(17-30)26-6-4-3-5-7-26/h8-9,14-19,23-24,26H,3-7,10-13,20-22H2,1-2H3,(H,36,40)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410073
PNG
(D2475 | US10370360, Example 25)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CC[C@@H](C2)N(C)C)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C29H33F3N6O/c1-19-14-38(26-12-33-18-34-13-26)16-22-10-21(4-5-27(19)22)28(39)35-24-9-20(8-23(11-24)29(30,31)32)15-37-7-6-25(17-37)36(2)3/h4-5,8-13,18-19,25H,6-7,14-17H2,1-3H3,(H,35,39)/t19?,25-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410074
PNG
(D2202 | US10370360, Example 26)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(cc(c1)C(F)(F)F)-n1cnc(C)c1)c1cncnc1
Show InChI InChI=1S/C26H23F3N6O/c1-16-11-34(23-9-30-14-31-10-23)13-19-5-18(3-4-24(16)19)25(36)33-21-6-20(26(27,28)29)7-22(8-21)35-12-17(2)32-15-35/h3-10,12,14-16H,11,13H2,1-2H3,(H,33,36)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410079
PNG
(D2347 | US10370360, Example 31)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C1CC1)c1cncnc1
Show InChI InChI=1S/C30H36N6O/c1-21-17-36(28-15-31-20-32-16-28)19-26-13-24(5-6-29(21)26)30(37)33-27-12-22(11-25(14-27)23-3-4-23)18-35-9-7-34(2)8-10-35/h5-6,11-16,20-21,23H,3-4,7-10,17-19H2,1-2H3,(H,33,37)
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The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410082
PNG
(D2213 | US10370360, Example 34)
Show SMILES CCC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C29H33F3N6O/c1-3-21-17-38(26-14-33-19-34-15-26)18-23-12-22(4-5-27(21)23)28(39)35-25-11-20(10-24(13-25)29(30,31)32)16-37-8-6-36(2)7-9-37/h4-5,10-15,19,21H,3,6-9,16-18H2,1-2H3,(H,35,39)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410083
PNG
(D2191 | US10370360, Example 35)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCSCC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C27H28F3N5OS/c1-18-14-35(24-12-31-17-32-13-24)16-21-10-20(2-3-25(18)21)26(36)33-23-9-19(8-22(11-23)27(28,29)30)15-34-4-6-37-7-5-34/h2-3,8-13,17-18H,4-7,14-16H2,1H3,(H,33,36)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410084
PNG
(D2212 | US10370360, Example 36)
Show SMILES CN1CCN(Cc2cc(cc(c2)C(F)(F)F)C(=O)Nc2ccc3CCN(Cc3c2)c2cncnc2)CC1
Show InChI InChI=1S/C27H29F3N6O/c1-34-6-8-35(9-7-34)16-19-10-21(12-23(11-19)27(28,29)30)26(37)33-24-3-2-20-4-5-36(17-22(20)13-24)25-14-31-18-32-15-25/h2-3,10-15,18H,4-9,16-17H2,1H3,(H,33,37)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50260024
PNG
(CHEMBL4095191 | US10370360, Example 3)
Show SMILES CN1CCN(Cc2cc(NC(=O)c3ccc4CCN(Cc4c3)c3cncnc3)cc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C27H29F3N6O/c1-34-6-8-35(9-7-34)16-19-10-23(27(28,29)30)13-24(11-19)33-26(37)21-3-2-20-4-5-36(17-22(20)12-21)25-14-31-18-32-15-25/h2-3,10-15,18H,4-9,16-17H2,1H3,(H,33,37)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM50260028
PNG
(CHEMBL4068810 | US10370360, Example 7)
Show SMILES CN1CCN(Cc2cc(NC(=O)c3ccc4c(CN(CC4(C)C)c4cncnc4)c3)cc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C29H33F3N6O/c1-28(2)18-38(25-14-33-19-34-15-25)17-22-12-21(4-5-26(22)28)27(39)35-24-11-20(10-23(13-24)29(30,31)32)16-37-8-6-36(3)7-9-37/h4-5,10-15,19H,6-9,16-18H2,1-3H3,(H,35,39)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410061
PNG
(D2199 | US10370360, Example 13)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cccc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C22H19F3N4O/c1-14-11-29(19-9-26-13-27-10-19)12-16-7-15(5-6-20(14)16)21(30)28-18-4-2-3-17(8-18)22(23,24)25/h2-10,13-14H,11-12H2,1H3,(H,28,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410066
PNG
(D2201 | US10370360, Example 18)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCOCC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C27H28F3N5O2/c1-18-14-35(24-12-31-17-32-13-24)16-21-10-20(2-3-25(18)21)26(36)33-23-9-19(8-22(11-23)27(28,29)30)15-34-4-6-37-7-5-34/h2-3,8-13,17-18H,4-7,14-16H2,1H3,(H,33,36)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410076
PNG
(D2350 | US10370360, Example 28)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(C)(C)C)c1cncnc1
Show InChI InChI=1S/C31H40N6O/c1-22-18-37(28-16-32-21-33-17-28)20-25-14-24(6-7-29(22)25)30(38)34-27-13-23(12-26(15-27)31(2,3)4)19-36-10-8-35(5)9-11-36/h6-7,12-17,21-22H,8-11,18-20H2,1-5H3,(H,34,38)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410084
PNG
(D2212 | US10370360, Example 36)
Show SMILES CN1CCN(Cc2cc(cc(c2)C(F)(F)F)C(=O)Nc2ccc3CCN(Cc3c2)c2cncnc2)CC1
Show InChI InChI=1S/C27H29F3N6O/c1-34-6-8-35(9-7-34)16-19-10-21(12-23(11-19)27(28,29)30)26(37)33-24-3-2-20-4-5-36(17-22(20)13-24)25-14-31-18-32-15-25/h2-3,10-15,18H,4-9,16-17H2,1H3,(H,33,37)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM50260033
PNG
(CHEMBL4066114 | US10370360, Example 38)
Show SMILES C[C@H]1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C28H31F3N6O/c1-19-15-37(25-13-32-18-33-14-25)17-22-11-21(3-4-26(19)22)27(38)34-24-10-20(9-23(12-24)28(29,30)31)16-36-7-5-35(2)6-8-36/h3-4,9-14,18-19H,5-8,15-17H2,1-2H3,(H,34,38)/t19-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM50260029
PNG
(CHEMBL4088388 | US10370360, Example 40)
Show SMILES C[C@H]1CN(Cc2cc(NC(=O)c3cc(CN4CCN(C)CC4)cc(c3)C(F)(F)F)ccc12)c1cncnc1
Show InChI InChI=1S/C28H31F3N6O/c1-19-15-37(25-13-32-18-33-14-25)17-22-12-24(3-4-26(19)22)34-27(38)21-9-20(10-23(11-21)28(29,30)31)16-36-7-5-35(2)6-8-36/h3-4,9-14,18-19H,5-8,15-17H2,1-2H3,(H,34,38)/t19-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410060
PNG
(D2190 | US10370360, Example 12)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1ccc(CN2CCN(C)CC2)c(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C28H31F3N6O/c1-19-15-37(24-13-32-18-33-14-24)17-22-11-20(4-6-25(19)22)27(38)34-23-5-3-21(26(12-23)28(29,30)31)16-36-9-7-35(2)8-10-36/h3-6,11-14,18-19H,7-10,15-17H2,1-2H3,(H,34,38)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2 (DDR2)


(Homo sapiens (Human))
BDBM410061
PNG
(D2199 | US10370360, Example 13)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cccc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C22H19F3N4O/c1-14-11-29(19-9-26-13-27-10-19)12-16-7-15(5-6-20(14)16)21(30)28-18-4-2-3-17(8-18)22(23,24)25/h2-10,13-14H,11-12H2,1H3,(H,28,30)
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n/an/a 1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410063
PNG
(D2193 | US10370360, Example 15)
Show SMILES CCc1cc(CN2CCN(C)CC2)cc(NC(=O)c2ccc3C(C)CN(Cc3c2)c2cncnc2)c1
Show InChI InChI=1S/C29H36N6O/c1-4-22-11-23(18-34-9-7-33(3)8-10-34)13-26(12-22)32-29(36)24-5-6-28-21(2)17-35(19-25(28)14-24)27-15-30-20-31-16-27/h5-6,11-16,20-21H,4,7-10,17-19H2,1-3H3,(H,32,36)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410067
PNG
(D2194 | US10370360, Example 19)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCCCC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C28H30F3N5O/c1-19-15-36(25-13-32-18-33-14-25)17-22-11-21(5-6-26(19)22)27(37)34-24-10-20(9-23(12-24)28(29,30)31)16-35-7-3-2-4-8-35/h5-6,9-14,18-19H,2-4,7-8,15-17H2,1H3,(H,34,37)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410075
PNG
(D2214 | US10370360, Example 27)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)c(F)c(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C28H30F4N6O/c1-18-14-38(23-12-33-17-34-13-23)16-20-9-19(3-4-24(18)20)27(39)35-22-10-21(15-37-7-5-36(2)6-8-37)26(29)25(11-22)28(30,31)32/h3-4,9-13,17-18H,5-8,14-16H2,1-2H3,(H,35,39)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410077
PNG
(D2476 | US10370360, Example 29)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)-c1ccccc1)c1cncnc1
Show InChI InChI=1S/C33H36N6O/c1-24-20-39(31-18-34-23-35-19-31)22-29-16-27(8-9-32(24)29)33(40)36-30-15-25(21-38-12-10-37(2)11-13-38)14-28(17-30)26-6-4-3-5-7-26/h3-9,14-19,23-24H,10-13,20-22H2,1-2H3,(H,36,40)
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n/an/a 1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM410078
PNG
(D2574 | US10370360, Example 30)
Show SMILES CC1Cc2ccc(cc2CN1c1cncnc1)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H31F3N6O/c1-19-9-21-3-4-22(12-23(21)17-37(19)26-14-32-18-33-15-26)27(38)34-25-11-20(10-24(13-25)28(29,30)31)16-36-7-5-35(2)6-8-36/h3-4,10-15,18-19H,5-9,16-17H2,1-2H3,(H,34,38)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Bcr-Abl


(Homo sapiens (Human))
BDBM410081
PNG
(D2195 | US10370360, Example 33)
Show SMILES CC1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(CC2)C2CCCCC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C33H39F3N6O/c1-23-19-42(30-17-37-22-38-18-30)21-26-15-25(7-8-31(23)26)32(43)39-28-14-24(13-27(16-28)33(34,35)36)20-40-9-11-41(12-10-40)29-5-3-2-4-6-29/h7-8,13-18,22-23,29H,2-6,9-12,19-21H2,1H3,(H,39,43)
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50260033
PNG
(CHEMBL4066114 | US10370360, Example 38)
Show SMILES C[C@H]1CN(Cc2cc(ccc12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F)c1cncnc1
Show InChI InChI=1S/C28H31F3N6O/c1-19-15-37(25-13-32-18-33-14-25)17-22-11-21(3-4-26(19)22)27(38)34-24-10-20(9-23(12-24)28(29,30)31)16-36-7-5-35(2)6-8-36/h3-4,9-14,18-19H,5-8,15-17H2,1-2H3,(H,34,38)/t19-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Board of Regents of the University of Texas System

US Patent


Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a Lantha Screen Eu kinase activity assay technology (Invitrogen, USA). K...


US Patent US10370360 (2019)


BindingDB Entry DOI: 10.7270/Q2BP054G
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Ligand-Target Pair
* indicates data uncertainty>20%