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Patent code US10370370

Compile Data Set for Download or QSAR
Found 89 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))		BDBM410097
PNG
(US10370370, Compound 2-P1)
Show SMILES Clc1cccc2c(N[C@H]3CN4CCC3CC4)noc12
Show InChI InChI=1S/C14H16ClN3O/c15-11-3-1-2-10-13(11)19-17-14(10)16-12-8-18-6-4-9(12)5-7-18/h1-3,9,12H,4-8H2,(H,16,17)/t12-/m0/s1
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 19n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))		BDBM410113
PNG
(US10370370, Compound 9-P2)
Show SMILES Clc1ccc2c(N[C@@H]3CN4CCC3CC4)noc2c1Cl
Show InChI InChI=1S/C14H15Cl2N3O/c15-10-2-1-9-13(12(10)16)20-18-14(9)17-11-7-19-5-3-8(11)4-6-19/h1-2,8,11H,3-7H2,(H,17,18)/t11-/m1/s1
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 26n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))		BDBM410139
PNG
(US10370370, Compound (R)-31)
Show SMILES Cc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1Cl
Show InChI InChI=1S/C15H18ClN3O/c1-9-2-3-11-14(13(9)16)20-18-15(11)17-12-8-19-6-4-10(12)5-7-19/h2-3,10,12H,4-8H2,1H3,(H,17,18)/t12-/m0/s1
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 29n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410099
PNG
(US10370370, Compound 3-P1)
Show SMILES Clc1ccc2c(NC3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C14H16ClN3O/c15-10-1-2-11-13(7-10)19-17-14(11)16-12-8-18-5-3-9(12)4-6-18/h1-2,7,9,12H,3-6,8H2,(H,16,17)
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 32n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410109
PNG
(US10370370, Compound 7-P2)
Show SMILES COc1ccc2c(N[C@@H]3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C15H19N3O2/c1-19-11-2-3-12-14(8-11)20-17-15(12)16-13-9-18-6-4-10(13)5-7-18/h2-3,8,10,13H,4-7,9H2,1H3,(H,16,17)/t13-/m1/s1
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 32n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410112
PNG
(US10370370, Compound 9-P1)
Show SMILES Clc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1Cl
Show InChI InChI=1S/C14H15Cl2N3O/c15-10-2-1-9-13(12(10)16)20-18-14(9)17-11-7-19-5-3-8(11)4-6-19/h1-2,8,11H,3-7H2,(H,17,18)/t11-/m0/s1
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 43.5n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410152
PNG
(US10370370, Compound (R)-43)
Show SMILES Brc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C14H16BrN3O/c15-10-1-2-11-13(7-10)19-17-14(11)16-12-8-18-5-3-9(12)4-6-18/h1-2,7,9,12H,3-6,8H2,(H,16,17)/t12-/m0/s1
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 44n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410148
PNG
(US10370370, Compound (R)-41)
Show SMILES Fc1c(Cl)ccc2c(N[C@H]3CN4CCC3CC4)noc12
Show InChI InChI=1S/C14H15ClFN3O/c15-10-2-1-9-13(12(10)16)20-18-14(9)17-11-7-19-5-3-8(11)4-6-19/h1-2,8,11H,3-7H2,(H,17,18)/t11-/m0/s1
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 46n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410101
PNG
(US10370370, Compound (R)-3)
Show SMILES Clc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C14H16ClN3O/c15-10-1-2-11-13(7-10)19-17-14(11)16-12-8-18-5-3-9(12)4-6-18/h1-2,7,9,12H,3-6,8H2,(H,16,17)/t12-/m0/s1
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 57n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))		BDBM410112
PNG
(US10370370, Compound 9-P1)
Show SMILES Clc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1Cl
Show InChI InChI=1S/C14H15Cl2N3O/c15-10-2-1-9-13(12(10)16)20-18-14(9)17-11-7-19-5-3-8(11)4-6-19/h1-2,8,11H,3-7H2,(H,17,18)/t11-/m0/s1
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 59.5n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))		BDBM410144
PNG
(US10370370, Compound (R)-35)
Show SMILES Fc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1Cl
Show InChI InChI=1S/C14H15ClFN3O/c15-12-10(16)2-1-9-13(12)20-18-14(9)17-11-7-19-5-3-8(11)4-6-19/h1-2,8,11H,3-7H2,(H,17,18)/t11-/m0/s1
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 65n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))		BDBM410096
PNG
(US10370370, Compound 1-P2)
Show SMILES C1CN2CCC1[C@@H](C2)Nc1noc2ccccc12
Show InChI InChI=1S/C14H17N3O/c1-2-4-13-11(3-1)14(16-18-13)15-12-9-17-7-5-10(12)6-8-17/h1-4,10,12H,5-9H2,(H,15,16)/t12-/m1/s1
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 69n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410130
PNG
(US10370370, Compound (R)-23)
Show SMILES Oc1c(Cl)ccc2c(N[C@H]3CN4CCC3CC4)noc12
Show InChI InChI=1S/C14H16ClN3O2/c15-10-2-1-9-13(12(10)19)20-17-14(9)16-11-7-18-5-3-8(11)4-6-18/h1-2,8,11,19H,3-7H2,(H,16,17)/t11-/m0/s1
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 71n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410147
PNG
(US10370370, Compound (R)-39)
Show SMILES CCOc1c(Cl)ccc2c(N[C@H]3CN4CCC3CC4)noc12
Show InChI InChI=1S/C16H20ClN3O2/c1-2-21-15-12(17)4-3-11-14(15)22-19-16(11)18-13-9-20-7-5-10(13)6-8-20/h3-4,10,13H,2,5-9H2,1H3,(H,18,19)/t13-/m0/s1
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 120n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410131
PNG
(US10370370, Compound (R)-24)
Show SMILES COc1c(Cl)ccc2c(N[C@H]3CN4CCC3CC4)noc12
Show InChI InChI=1S/C15H18ClN3O2/c1-20-14-11(16)3-2-10-13(14)21-18-15(10)17-12-8-19-6-4-9(12)5-7-19/h2-3,9,12H,4-8H2,1H3,(H,17,18)/t12-/m0/s1
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 140n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410129
PNG
(US10370370, Compound (R)-22)
Show SMILES Cc1cc2onc(N[C@H]3CN4CCC3CC4)c2cc1F
Show InChI InChI=1S/C15H18FN3O/c1-9-6-14-11(7-12(9)16)15(18-20-14)17-13-8-19-4-2-10(13)3-5-19/h6-7,10,13H,2-5,8H2,1H3,(H,17,18)/t13-/m0/s1
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 140n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410105
PNG
(US10370370, Compound 5-P2)
Show SMILES Cc1ccc2c(N[C@@H]3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C15H19N3O/c1-10-2-3-12-14(8-10)19-17-15(12)16-13-9-18-6-4-11(13)5-7-18/h2-3,8,11,13H,4-7,9H2,1H3,(H,16,17)/t13-/m1/s1
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 159n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))		BDBM410104
PNG
(US10370370, Compound 5-P1)
Show SMILES Cc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C15H19N3O/c1-10-2-3-12-14(8-10)19-17-15(12)16-13-9-18-6-4-11(13)5-7-18/h2-3,8,11,13H,4-7,9H2,1H3,(H,16,17)/t13-/m0/s1
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 160n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410139
PNG
(US10370370, Compound (R)-31)
Show SMILES Cc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1Cl
Show InChI InChI=1S/C15H18ClN3O/c1-9-2-3-11-14(13(9)16)20-18-15(11)17-12-8-19-6-4-10(12)5-7-19/h2-3,10,12H,4-8H2,1H3,(H,17,18)/t12-/m0/s1
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 180n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410144
PNG
(US10370370, Compound (R)-35)
Show SMILES Fc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1Cl
Show InChI InChI=1S/C14H15ClFN3O/c15-12-10(16)2-1-9-13(12)20-18-14(9)17-11-7-19-5-3-8(11)4-6-19/h1-2,8,11H,3-7H2,(H,17,18)/t11-/m0/s1
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 180n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))		BDBM410130
PNG
(US10370370, Compound (R)-23)
Show SMILES Oc1c(Cl)ccc2c(N[C@H]3CN4CCC3CC4)noc12
Show InChI InChI=1S/C14H16ClN3O2/c15-10-2-1-9-13(12(10)19)20-17-14(9)16-11-7-18-5-3-8(11)4-6-18/h1-2,8,11,19H,3-7H2,(H,16,17)/t11-/m0/s1
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 190n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410127
PNG
(US10370370, Compound (R)-20)
Show SMILES Cc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1F
Show InChI InChI=1S/C15H18FN3O/c1-9-2-3-11-14(13(9)16)20-18-15(11)17-12-8-19-6-4-10(12)5-7-19/h2-3,10,12H,4-8H2,1H3,(H,17,18)/t12-/m0/s1
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 220n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))		BDBM410123
PNG
(US10370370, Compound (R)-17)
Show SMILES Fc1cccc2c(N[C@H]3CN4CCC3CC4)noc12
Show InChI InChI=1S/C14H16FN3O/c15-11-3-1-2-10-13(11)19-17-14(10)16-12-8-18-6-4-9(12)5-7-18/h1-3,9,12H,4-8H2,(H,16,17)/t12-/m0/s1
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 240n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410132
PNG
(US10370370, Compound (R)-25)
Show SMILES FC(F)(F)c1c(Cl)ccc2c(N[C@H]3CN4CCC3CC4)noc12
Show InChI InChI=1S/C15H15ClF3N3O/c16-10-2-1-9-13(12(10)15(17,18)19)23-21-14(9)20-11-7-22-5-3-8(11)4-6-22/h1-2,8,11H,3-7H2,(H,20,21)/t11-/m0/s1
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 245n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))		BDBM410100
PNG
(US10370370, Compound 3-P2)
Show SMILES Clc1ccc2c(N[C@@H]3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C14H16ClN3O/c15-10-1-2-11-13(7-10)19-17-14(11)16-12-8-18-5-3-9(12)4-6-18/h1-2,7,9,12H,3-6,8H2,(H,16,17)/t12-/m1/s1
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Axovant Sciences GmbH

US Patent


Assay Description
α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410150
PNG
(US10370370, Compound (R)-42)
Show SMILES Fc1cc2c(N[C@H]3CN4CCC3CC4)noc2cc1Cl
Show InChI InChI=1S/C14H15ClFN3O/c15-10-6-13-9(5-11(10)16)14(18-20-13)17-12-7-19-3-1-8(12)2-4-19/h5-6,8,12H,1-4,7H2,(H,17,18)/t12-/m0/s1
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 260n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))		BDBM410137
PNG
(US10370370, Compound (R)-30)
Show SMILES COc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1Cl
Show InChI InChI=1S/C15H18ClN3O2/c1-20-12-3-2-10-14(13(12)16)21-18-15(10)17-11-8-19-6-4-9(11)5-7-19/h2-3,9,11H,4-8H2,1H3,(H,17,18)/t11-/m0/s1
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Axovant Sciences GmbH

US Patent


Assay Description
α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410113
PNG
(US10370370, Compound 9-P2)
Show SMILES Clc1ccc2c(N[C@@H]3CN4CCC3CC4)noc2c1Cl
Show InChI InChI=1S/C14H15Cl2N3O/c15-10-2-1-9-13(12(10)16)20-18-14(9)17-11-7-19-5-3-8(11)4-6-19/h1-2,8,11H,3-7H2,(H,17,18)/t11-/m1/s1
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Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410108
PNG
(US10370370, Compound 7-P1)
Show SMILES COc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C15H19N3O2/c1-19-11-2-3-12-14(8-11)20-17-15(12)16-13-9-18-6-4-10(13)5-7-18/h2-3,8,10,13H,4-7,9H2,1H3,(H,16,17)/t13-/m0/s1
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 360n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410097
PNG
(US10370370, Compound 2-P1)
Show SMILES Clc1cccc2c(N[C@H]3CN4CCC3CC4)noc12
Show InChI InChI=1S/C14H16ClN3O/c15-11-3-1-2-10-13(11)19-17-14(10)16-12-8-18-6-4-9(12)5-7-18/h1-3,9,12H,4-8H2,(H,16,17)/t12-/m0/s1
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Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))		BDBM410131
PNG
(US10370370, Compound (R)-24)
Show SMILES COc1c(Cl)ccc2c(N[C@H]3CN4CCC3CC4)noc12
Show InChI InChI=1S/C15H18ClN3O2/c1-20-14-11(16)3-2-10-13(14)21-18-15(10)17-12-8-19-6-4-9(12)5-7-19/h2-3,9,12H,4-8H2,1H3,(H,17,18)/t12-/m0/s1
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 400n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410107
PNG
(US10370370, Compound 6-P2)
Show SMILES C1CC1c1ccc2c(N[C@@H]3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C17H21N3O/c1-2-11(1)13-3-4-14-16(9-13)21-19-17(14)18-15-10-20-7-5-12(15)6-8-20/h3-4,9,11-12,15H,1-2,5-8,10H2,(H,18,19)/t15-/m1/s1
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 410n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410100
PNG
(US10370370, Compound 3-P2)
Show SMILES Clc1ccc2c(N[C@@H]3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C14H16ClN3O/c15-10-1-2-11-13(7-10)19-17-14(11)16-12-8-18-5-3-9(12)4-6-18/h1-2,7,9,12H,3-6,8H2,(H,16,17)/t12-/m1/s1
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Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410115
PNG
(US10370370, Compound (R)-11)
Show SMILES Fc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C14H16FN3O/c15-10-1-2-11-13(7-10)19-17-14(11)16-12-8-18-5-3-9(12)4-6-18/h1-2,7,9,12H,3-6,8H2,(H,16,17)/t12-/m0/s1
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Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))		BDBM410127
PNG
(US10370370, Compound (R)-20)
Show SMILES Cc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1F
Show InChI InChI=1S/C15H18FN3O/c1-9-2-3-11-14(13(9)16)20-18-15(11)17-12-8-19-6-4-10(12)5-7-19/h2-3,10,12H,4-8H2,1H3,(H,17,18)/t12-/m0/s1
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Axovant Sciences GmbH

US Patent


Assay Description
α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410149
PNG
(US10370370, Compound (S)-41)
Show SMILES Fc1c(Cl)ccc2c(N[C@@H]3CN4CCC3CC4)noc12
Show InChI InChI=1S/C14H15ClFN3O/c15-10-2-1-9-13(12(10)16)20-18-14(9)17-11-7-19-5-3-8(11)4-6-19/h1-2,8,11H,3-7H2,(H,17,18)/t11-/m1/s1
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 670n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410134
PNG
(US10370370, Compound (R)-27)
Show SMILES Fc1cc(Cl)cc2onc(N[C@H]3CN4CCC3CC4)c12
Show InChI InChI=1S/C14H15ClFN3O/c15-9-5-10(16)13-12(6-9)20-18-14(13)17-11-7-19-3-1-8(11)2-4-19/h5-6,8,11H,1-4,7H2,(H,17,18)/t11-/m0/s1
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Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410145
PNG
(US10370370, Compound (R)-36)
Show SMILES C1CN2CCC1[C@H](C2)Nc1noc2cc(ccc12)-n1cccn1
Show InChI InChI=1S/C17H19N5O/c1-6-18-22(7-1)13-2-3-14-16(10-13)23-20-17(14)19-15-11-21-8-4-12(15)5-9-21/h1-3,6-7,10,12,15H,4-5,8-9,11H2,(H,19,20)/t15-/m0/s1
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 700n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))		BDBM410108
PNG
(US10370370, Compound 7-P1)
Show SMILES COc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C15H19N3O2/c1-19-11-2-3-12-14(8-11)20-17-15(12)16-13-9-18-6-4-10(13)5-7-18/h2-3,8,10,13H,4-7,9H2,1H3,(H,16,17)/t13-/m0/s1
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 740n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410116
PNG
(US10370370, Compound (R)-12)
Show SMILES N#Cc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C15H16N4O/c16-8-10-1-2-12-14(7-10)20-18-15(12)17-13-9-19-5-3-11(13)4-6-19/h1-2,7,11,13H,3-6,9H2,(H,17,18)/t13-/m0/s1
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 740n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410142
PNG
(US10370370, Compound (R)-33)
Show SMILES CCOc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C16H21N3O2/c1-2-20-12-3-4-13-15(9-12)21-18-16(13)17-14-10-19-7-5-11(14)6-8-19/h3-4,9,11,14H,2,5-8,10H2,1H3,(H,17,18)/t14-/m0/s1
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 750n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410095
PNG
(US10370370, Compound 1-P1)
Show SMILES C1CN2CCC1[C@H](C2)Nc1noc2ccccc12
Show InChI InChI=1S/C14H17N3O/c1-2-4-13-11(3-1)14(16-18-13)15-12-9-17-7-5-10(12)6-8-17/h1-4,10,12H,5-9H2,(H,15,16)/t12-/m0/s1
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 815n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410128
PNG
(US10370370, Compound (R)-21)
Show SMILES Fc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1F
Show InChI InChI=1S/C14H15F2N3O/c15-10-2-1-9-13(12(10)16)20-18-14(9)17-11-7-19-5-3-8(11)4-6-19/h1-2,8,11H,3-7H2,(H,17,18)/t11-/m0/s1
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Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410136
PNG
(US10370370, Compound (R)-29)
Show SMILES COc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1F
Show InChI InChI=1S/C15H18FN3O2/c1-20-12-3-2-10-14(13(12)16)21-18-15(10)17-11-8-19-6-4-9(11)5-7-19/h2-3,9,11H,4-8H2,1H3,(H,17,18)/t11-/m0/s1
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 925n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410120
PNG
(US10370370, Compound (R)-15)
Show SMILES Clc1cc2onc(N[C@H]3CN4CCC3CC4)c2cc1Cl
Show InChI InChI=1S/C14H15Cl2N3O/c15-10-5-9-13(6-11(10)16)20-18-14(9)17-12-7-19-3-1-8(12)2-4-19/h5-6,8,12H,1-4,7H2,(H,17,18)/t12-/m0/s1
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Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))		BDBM410152
PNG
(US10370370, Compound (R)-43)
Show SMILES Brc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C14H16BrN3O/c15-10-1-2-11-13(7-10)19-17-14(11)16-12-8-18-5-3-9(12)4-6-18/h1-2,7,9,12H,3-6,8H2,(H,16,17)/t12-/m0/s1
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 930n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410106
PNG
(US10370370, Compound 6-P1)
Show SMILES C1CC1c1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C17H21N3O/c1-2-11(1)13-3-4-14-16(9-13)21-19-17(14)18-15-10-20-7-5-12(15)6-8-20/h3-4,9,11-12,15H,1-2,5-8,10H2,(H,18,19)/t15-/m0/s1
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US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410151
PNG
(US10370370, Compound (S)-42)
Show SMILES Fc1cc2c(N[C@@H]3CN4CCC3CC4)noc2cc1Cl
Show InChI InChI=1S/C14H15ClFN3O/c15-10-6-13-9(5-11(10)16)14(18-20-13)17-12-7-19-3-1-8(12)2-4-19/h5-6,8,12H,1-4,7H2,(H,17,18)/t12-/m1/s1
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US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410102
PNG
(US10370370, Compound 4-P1)
Show SMILES Clc1ccc2onc(N[C@H]3CN4CCC3CC4)c2c1
Show InChI InChI=1S/C14H16ClN3O/c15-10-1-2-13-11(7-10)14(17-19-13)16-12-8-18-5-3-9(12)4-6-18/h1-2,7,9,12H,3-6,8H2,(H,16,17)/t12-/m0/s1
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US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410104
PNG
(US10370370, Compound 5-P1)
Show SMILES Cc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C15H19N3O/c1-10-2-3-12-14(8-10)19-17-15(12)16-13-9-18-6-4-11(13)5-7-18/h2-3,8,11,13H,4-7,9H2,1H3,(H,16,17)/t13-/m0/s1
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US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))		BDBM410133
PNG
(US10370370, Compound (R)-26)
Show SMILES Clc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1C1CC1
Show InChI InChI=1S/C17H20ClN3O/c18-13-4-3-12-16(15(13)11-1-2-11)22-20-17(12)19-14-9-21-7-5-10(14)6-8-21/h3-4,10-11,14H,1-2,5-9H2,(H,19,20)/t14-/m0/s1
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 1.20E+3n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410111
PNG
(US10370370, Compound 8-P2)
Show SMILES FC(F)(F)c1ccc2c(N[C@@H]3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C15H16F3N3O/c16-15(17,18)10-1-2-11-13(7-10)22-20-14(11)19-12-8-21-5-3-9(12)4-6-21/h1-2,7,9,12H,3-6,8H2,(H,19,20)/t12-/m1/s1
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US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))		BDBM410099
PNG
(US10370370, Compound 3-P1)
Show SMILES Clc1ccc2c(NC3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C14H16ClN3O/c15-10-1-2-11-13(7-10)19-17-14(11)16-12-8-18-5-3-9(12)4-6-18/h1-2,7,9,12H,3-6,8H2,(H,16,17)
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 1.40E+3n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))		BDBM410128
PNG
(US10370370, Compound (R)-21)
Show SMILES Fc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1F
Show InChI InChI=1S/C14H15F2N3O/c15-10-2-1-9-13(12(10)16)20-18-14(9)17-11-7-19-5-3-8(11)4-6-19/h1-2,8,11H,3-7H2,(H,17,18)/t11-/m0/s1
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Axovant Sciences GmbH

US Patent


Assay Description
α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))		BDBM410150
PNG
(US10370370, Compound (R)-42)
Show SMILES Fc1cc2c(N[C@H]3CN4CCC3CC4)noc2cc1Cl
Show InChI InChI=1S/C14H15ClFN3O/c15-10-6-13-9(5-11(10)16)14(18-20-13)17-12-7-19-3-1-8(12)2-4-19/h5-6,8,12H,1-4,7H2,(H,17,18)/t12-/m0/s1
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 1.55E+3n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))		BDBM410106
PNG
(US10370370, Compound 6-P1)
Show SMILES C1CC1c1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C17H21N3O/c1-2-11(1)13-3-4-14-16(9-13)21-19-17(14)18-15-10-20-7-5-12(15)6-8-20/h3-4,9,11-12,15H,1-2,5-8,10H2,(H,18,19)/t15-/m0/s1
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 1.60E+3n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))		BDBM410148
PNG
(US10370370, Compound (R)-41)
Show SMILES Fc1c(Cl)ccc2c(N[C@H]3CN4CCC3CC4)noc12
Show InChI InChI=1S/C14H15ClFN3O/c15-10-2-1-9-13(12(10)16)20-18-14(9)17-11-7-19-5-3-8(11)4-6-19/h1-2,8,11H,3-7H2,(H,17,18)/t11-/m0/s1
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 1.63E+3n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410123
PNG
(US10370370, Compound (R)-17)
Show SMILES Fc1cccc2c(N[C@H]3CN4CCC3CC4)noc12
Show InChI InChI=1S/C14H16FN3O/c15-11-3-1-2-10-13(11)19-17-14(10)16-12-8-18-6-4-9(12)5-7-18/h1-3,9,12H,4-8H2,(H,16,17)/t12-/m0/s1
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 1.70E+3n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))		BDBM410105
PNG
(US10370370, Compound 5-P2)
Show SMILES Cc1ccc2c(N[C@@H]3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C15H19N3O/c1-10-2-3-12-14(8-10)19-17-15(12)16-13-9-18-6-4-11(13)5-7-18/h2-3,8,11,13H,4-7,9H2,1H3,(H,16,17)/t13-/m1/s1
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 1.85E+3n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))		BDBM410095
PNG
(US10370370, Compound 1-P1)
Show SMILES C1CN2CCC1[C@H](C2)Nc1noc2ccccc12
Show InChI InChI=1S/C14H17N3O/c1-2-4-13-11(3-1)14(16-18-13)15-12-9-17-7-5-10(12)6-8-17/h1-4,10,12H,5-9H2,(H,15,16)/t12-/m0/s1
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 1.90E+3n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))		BDBM410115
PNG
(US10370370, Compound (R)-11)
Show SMILES Fc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C14H16FN3O/c15-10-1-2-11-13(7-10)19-17-14(11)16-12-8-18-5-3-9(12)4-6-18/h1-2,7,9,12H,3-6,8H2,(H,16,17)/t12-/m0/s1
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US Patent


Assay Description
α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410124
PNG
(US10370370, Compound (R)-18)
Show SMILES Fc1ccc2onc(N[C@H]3CN4CCC3CC4)c2c1
Show InChI InChI=1S/C14H16FN3O/c15-10-1-2-13-11(7-10)14(17-19-13)16-12-8-18-5-3-9(12)4-6-18/h1-2,7,9,12H,3-6,8H2,(H,16,17)/t12-/m0/s1
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US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410122
PNG
(US10370370, Compound (R)-16)
Show SMILES FC(F)(F)Oc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C15H16F3N3O2/c16-15(17,18)22-10-1-2-11-13(7-10)23-20-14(11)19-12-8-21-5-3-9(12)4-6-21/h1-2,7,9,12H,3-6,8H2,(H,19,20)/t12-/m0/s1
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Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410137
PNG
(US10370370, Compound (R)-30)
Show SMILES COc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1Cl
Show InChI InChI=1S/C15H18ClN3O2/c1-20-12-3-2-10-14(13(12)16)21-18-15(10)17-11-8-19-6-4-9(11)5-7-19/h2-3,9,11H,4-8H2,1H3,(H,17,18)/t11-/m0/s1
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Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))		BDBM410129
PNG
(US10370370, Compound (R)-22)
Show SMILES Cc1cc2onc(N[C@H]3CN4CCC3CC4)c2cc1F
Show InChI InChI=1S/C15H18FN3O/c1-9-6-14-11(7-12(9)16)15(18-20-14)17-13-8-19-4-2-10(13)3-5-19/h6-7,10,13H,2-5,8H2,1H3,(H,17,18)/t13-/m0/s1
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US Patent


Assay Description
α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410098
PNG
(US10370370, Compound 2-P2)
Show SMILES Clc1cccc2c(N[C@@H]3CN4CCC3CC4)noc12
Show InChI InChI=1S/C14H16ClN3O/c15-11-3-1-2-10-13(11)19-17-14(10)16-12-8-18-6-4-9(12)5-7-18/h1-3,9,12H,4-8H2,(H,16,17)/t12-/m1/s1
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 3.50E+3n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))		BDBM410132
PNG
(US10370370, Compound (R)-25)
Show SMILES FC(F)(F)c1c(Cl)ccc2c(N[C@H]3CN4CCC3CC4)noc12
Show InChI InChI=1S/C15H15ClF3N3O/c16-10-2-1-9-13(12(10)15(17,18)19)23-21-14(9)20-11-7-22-5-3-8(11)4-6-22/h1-2,8,11H,3-7H2,(H,20,21)/t11-/m0/s1
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US Patent
 4.10E+3n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))		BDBM410109
PNG
(US10370370, Compound 7-P2)
Show SMILES COc1ccc2c(N[C@@H]3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C15H19N3O2/c1-19-11-2-3-12-14(8-11)20-17-15(12)16-13-9-18-6-4-10(13)5-7-18/h2-3,8,10,13H,4-7,9H2,1H3,(H,16,17)/t13-/m1/s1
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 4.20E+3n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410140
PNG
(US10370370, Compound (R)-32)
Show SMILES CC(C)Oc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C17H23N3O2/c1-11(2)21-13-3-4-14-16(9-13)22-19-17(14)18-15-10-20-7-5-12(15)6-8-20/h3-4,9,11-12,15H,5-8,10H2,1-2H3,(H,18,19)/t15-/m0/s1
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US Patent
 4.30E+3n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410096
PNG
(US10370370, Compound 1-P2)
Show SMILES C1CN2CCC1[C@@H](C2)Nc1noc2ccccc12
Show InChI InChI=1S/C14H17N3O/c1-2-4-13-11(3-1)14(16-18-13)15-12-9-17-7-5-10(12)6-8-17/h1-4,10,12H,5-9H2,(H,15,16)/t12-/m1/s1
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US Patent
 5.05E+3n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410143
PNG
(US10370370, Compound (S)-33)
Show SMILES CCOc1ccc2c(N[C@@H]3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C16H21N3O2/c1-2-20-12-3-4-13-15(9-12)21-18-16(13)17-14-10-19-7-5-11(14)6-8-19/h3-4,9,11,14H,2,5-8,10H2,1H3,(H,17,18)/t14-/m1/s1
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US Patent
 5.80E+3n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410110
PNG
(US10370370, Compound 8-P1)
Show SMILES FC(F)(F)c1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C15H16F3N3O/c16-15(17,18)10-1-2-11-13(7-10)22-20-14(11)19-12-8-21-5-3-9(12)4-6-21/h1-2,7,9,12H,3-6,8H2,(H,19,20)/t12-/m0/s1
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 6.80E+3n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))		BDBM410147
PNG
(US10370370, Compound (R)-39)
Show SMILES CCOc1c(Cl)ccc2c(N[C@H]3CN4CCC3CC4)noc12
Show InChI InChI=1S/C16H20ClN3O2/c1-2-21-15-12(17)4-3-11-14(15)22-19-16(11)18-13-9-20-7-5-10(13)6-8-20/h3-4,10,13H,2,5-9H2,1H3,(H,18,19)/t13-/m0/s1
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 6.90E+3n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410138
PNG
(US10370370, Compound (S)-30)
Show SMILES COc1ccc2c(N[C@@H]3CN4CCC3CC4)noc2c1Cl
Show InChI InChI=1S/C15H18ClN3O2/c1-20-12-3-2-10-14(13(12)16)21-18-15(10)17-11-8-19-6-4-9(11)5-7-19/h2-3,9,11H,4-8H2,1H3,(H,17,18)/t11-/m1/s1
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US Patent
 7.40E+3n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410146
PNG
(US10370370, Compound (R)-37)
Show SMILES Cc1nnc(o1)-c1ccc(\C(N[C@H]2CN3CCC2CC3)=N\O)c(F)c1
Show InChI InChI=1S/C17H20FN5O2/c1-10-20-21-17(25-10)12-2-3-13(14(18)8-12)16(22-24)19-15-9-23-6-4-11(15)5-7-23/h2-3,8,11,15,24H,4-7,9H2,1H3,(H,19,22)/t15-/m0/s1
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 9.00E+3n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410126
PNG
(US10370370, Compound (R)-19)
Show SMILES Fc1cccc2onc(N[C@H]3CN4CCC3CC4)c12
Show InChI InChI=1S/C14H16FN3O/c15-10-2-1-3-12-13(10)14(17-19-12)16-11-8-18-6-4-9(11)5-7-18/h1-3,9,11H,4-8H2,(H,16,17)/t11-/m0/s1
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 9.70E+3n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))		BDBM410142
PNG
(US10370370, Compound (R)-33)
Show SMILES CCOc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C16H21N3O2/c1-2-20-12-3-4-13-15(9-12)21-18-16(13)17-14-10-19-7-5-11(14)6-8-19/h3-4,9,11,14H,2,5-8,10H2,1H3,(H,17,18)/t14-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))		BDBM410136
PNG
(US10370370, Compound (R)-29)
Show SMILES COc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1F
Show InChI InChI=1S/C15H18FN3O2/c1-20-12-3-2-10-14(13(12)16)21-18-15(10)17-11-8-19-6-4-9(11)5-7-19/h2-3,9,11H,4-8H2,1H3,(H,17,18)/t11-/m0/s1
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Axovant Sciences GmbH

US Patent


Assay Description
α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))		BDBM410107
PNG
(US10370370, Compound 6-P2)
Show SMILES C1CC1c1ccc2c(N[C@@H]3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C17H21N3O/c1-2-11(1)13-3-4-14-16(9-13)21-19-17(14)18-15-10-20-7-5-12(15)6-8-20/h3-4,9,11-12,15H,1-2,5-8,10H2,(H,18,19)/t15-/m1/s1
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Axovant Sciences GmbH

US Patent


Assay Description
α7 nAChR: The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affin...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410133
PNG
(US10370370, Compound (R)-26)
Show SMILES Clc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1C1CC1
Show InChI InChI=1S/C17H20ClN3O/c18-13-4-3-12-16(15(13)11-1-2-11)22-20-17(12)19-14-9-21-7-5-10(14)6-8-21/h3-4,10-11,14H,1-2,5-9H2,(H,19,20)/t14-/m0/s1
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US Patent
 1.10E+4n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410135
PNG
(US10370370, Compound (R)-28)
Show SMILES Clc1cc(Cl)c2c(N[C@H]3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C14H15Cl2N3O/c15-9-5-10(16)13-12(6-9)20-18-14(13)17-11-7-19-3-1-8(11)2-4-19/h5-6,8,11H,1-4,7H2,(H,17,18)/t11-/m0/s1
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 1.40E+4n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410103
PNG
(US10370370, Compound 4-P2)
Show SMILES Clc1ccc2onc(N[C@@H]3CN4CCC3CC4)c2c1
Show InChI InChI=1S/C14H16ClN3O/c15-10-1-2-13-11(7-10)14(17-19-13)16-12-8-18-5-3-9(12)4-6-18/h1-2,7,9,12H,3-6,8H2,(H,16,17)/t12-/m1/s1
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 1.60E+4n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410141
PNG
(US10370370, Compound (S)-32)
Show SMILES CC(C)Oc1ccc2c(N[C@@H]3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C17H23N3O2/c1-11(2)21-13-3-4-14-16(9-13)22-19-17(14)18-15-10-20-7-5-12(15)6-8-20/h3-4,9,11-12,15H,5-8,10H2,1-2H3,(H,18,19)/t15-/m1/s1
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 1.80E+4n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410125
PNG
(US10370370, Compound (S)-18)
Show SMILES Fc1ccc2onc(N[C@@H]3CN4CCC3CC4)c2c1
Show InChI InChI=1S/C14H16FN3O/c15-10-1-2-13-11(7-10)14(17-19-13)16-12-8-18-5-3-9(12)4-6-18/h1-2,7,9,12H,3-6,8H2,(H,16,17)/t12-/m1/s1
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 2.40E+4n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410117
PNG
(US10370370, Compound (R)-13)
Show SMILES CS(=O)(=O)c1cc(F)c2c(N[C@H]3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C15H18FN3O3S/c1-23(20,21)10-6-11(16)14-13(7-10)22-18-15(14)17-12-8-19-4-2-9(12)3-5-19/h6-7,9,12H,2-5,8H2,1H3,(H,17,18)/t12-/m0/s1
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Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410118
PNG
(US10370370, Compound (S)-13)
Show SMILES CS(=O)(=O)c1cc(F)c2c(N[C@@H]3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C15H18FN3O3S/c1-23(20,21)10-6-11(16)14-13(7-10)22-18-15(14)17-12-8-19-4-2-9(12)3-5-19/h6-7,9,12H,2-5,8H2,1H3,(H,17,18)/t12-/m1/s1
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Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410119
PNG
(US10370370, Compound (R)-14)
Show SMILES CC(C)(C)c1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1
Show InChI InChI=1S/C18H25N3O/c1-18(2,3)13-4-5-14-16(10-13)22-20-17(14)19-15-11-21-8-6-12(15)7-9-21/h4-5,10,12,15H,6-9,11H2,1-3H3,(H,19,20)/t15-/m0/s1
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US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410114
PNG
(US10370370, Compound (R)-10)
Show SMILES Clc1cccc2onc(N[C@@H]3CN4CCC3CC4)c12
Show InChI InChI=1S/C14H16ClN3O/c15-10-2-1-3-12-13(10)14(17-19-12)16-11-8-18-6-4-9(11)5-7-18/h1-3,9,11H,4-8H2,(H,16,17)/t11-/m1/s1
PDB

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PC cid
PC sid
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US Patent
>3.00E+4n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM410121
PNG
(US10370370, Compound (S)-15)
Show SMILES Clc1cc2onc(N[C@@H]3CN4CCC3CC4)c2cc1Cl
Show InChI InChI=1S/C14H15Cl2N3O/c15-10-5-9-13(6-11(10)16)20-18-14(9)17-12-7-19-3-1-8(12)2-4-19/h5-6,8,12H,1-4,7H2,(H,17,18)/t12-/m1/s1
PDB

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PC cid
PC sid
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US Patent
 5.20E+4n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
h-5HT3: In brief, Chinese Hamster Ovary (CHO) cells stably expressing human 5-HT3 serotonin receptors, grown to confluence in 175 cm2 flasks. Followi...

US Patent US10370370 (2019)


BindingDB Entry DOI: 10.7270/Q2348NRP
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%