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Patent code US10370375

Compile Data Set for Download or QSAR
Found 84 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK1 (aa 866-1154)


(Homo sapiens (Human))
BDBM410174
PNG
(US10370375, Example 22)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)n1cnc2cnc3[nH]ccc3c12
PDB
MMDB

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n/an/a 10n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (aa 866-1154)


(Homo sapiens (Human))
BDBM410170
PNG
(US10370375, Example 18)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1c(cnc2[nH]ccc12)N([O-])=O
PDB
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n/an/a 21n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (aa 866-1154)


(Homo sapiens (Human))
BDBM410178
PNG
(US10370375, Example 26)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1c(cnc2[nH]ccc12)C#N
PDB
MMDB

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n/an/a 34n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (aa 866-1154)


(Homo sapiens (Human))
BDBM410177
PNG
(US10370375, Example 25)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Oc1c(cnc2[nH]ccc12)[N+]([O-])=O
PDB
MMDB

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n/an/a 71n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
TYK2 (aa 888-1187)


(Homo sapiens (Human))
BDBM410174
PNG
(US10370375, Example 22)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)n1cnc2cnc3[nH]ccc3c12
PDB

GoogleScholar
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PC sid
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n/an/a 130n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
JAK3 (aa 811-1124)


(Homo sapiens (Human))
BDBM410174
PNG
(US10370375, Example 22)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)n1cnc2cnc3[nH]ccc3c12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 260n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
TYK2 (aa 888-1187)


(Homo sapiens (Human))
BDBM410170
PNG
(US10370375, Example 18)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1c(cnc2[nH]ccc12)N([O-])=O
PDB

GoogleScholar
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PC sid
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US Patent
n/an/a 390n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (aa 866-1154)


(Homo sapiens (Human))
BDBM410180
PNG
(US10370375, Example 28)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ncnn2cccc12
Show InChI InChI=1S/C15H23N5O2S/c1-16-23(21,22)10-12-5-7-13(8-6-12)19(2)15-14-4-3-9-20(14)18-11-17-15/h3-4,9,11-13,16H,5-8,10H2,1-2H3/t12-,13?
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n/an/a 550n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (aa 866-1154)


(Homo sapiens (Human))
BDBM410154
PNG
(US10370375, Example 2)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ncnc2[nH]cnc12
PDB
MMDB

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n/an/a 582n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (aa 866-1154)


(Homo sapiens (Human))
BDBM410153
PNG
(US10370375, Example 1)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ncnc2[nH]c(C)nc12
PDB
MMDB

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n/an/a 838n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
TYK2 (aa 888-1187)


(Homo sapiens (Human))
BDBM410178
PNG
(US10370375, Example 26)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1c(cnc2[nH]ccc12)C#N
PDB

GoogleScholar
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n/an/a 840n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (aa 866-1154)


(Homo sapiens (Human))
BDBM410176
PNG
(US10370375, Example 24)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1c(cnn2cccc12)C#N
Show InChI InChI=1S/C17H23N5O2S/c1-19-25(23,24)12-13-5-7-15(8-6-13)21(2)17-14(10-18)11-20-22-9-3-4-16(17)22/h3-4,9,11,13,15,19H,5-8,12H2,1-2H3/t13-,15?
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n/an/a 930n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
TYK2 (aa 888-1187)


(Homo sapiens (Human))
BDBM410177
PNG
(US10370375, Example 25)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Oc1c(cnc2[nH]ccc12)[N+]([O-])=O
PDB

GoogleScholar
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PC sid
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US Patent
n/an/a 1.10E+3n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
JAK3 (aa 811-1124)


(Homo sapiens (Human))
BDBM410170
PNG
(US10370375, Example 18)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1c(cnc2[nH]ccc12)N([O-])=O
PDB

GoogleScholar
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PC sid
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US Patent
n/an/a 1.20E+3n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (aa 866-1154)


(Homo sapiens (Human))
BDBM410179
PNG
(US10370375, Example 27)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1c(cnn2cccc12)C#N
Show InChI InChI=1S/C16H21N5O2S/c1-18-24(22,23)11-12-4-6-14(7-5-12)20-16-13(9-17)10-19-21-8-2-3-15(16)21/h2-3,8,10,12,14,18,20H,4-7,11H2,1H3/t12-,14?
PDB
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
JAK3 (aa 811-1124)


(Homo sapiens (Human))
BDBM410154
PNG
(US10370375, Example 2)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ncnc2[nH]cnc12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.89E+3n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (aa 866-1154)


(Homo sapiens (Human))
BDBM410165
PNG
(US10370375, Example 13)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1nc(N)ncc1Br
Show InChI InChI=1S/C12H20BrN5O2S/c1-15-21(19,20)7-8-2-4-9(5-3-8)17-11-10(13)6-16-12(14)18-11/h6,8-9,15H,2-5,7H2,1H3,(H3,14,16,17,18)/t8-,9?
PDB
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
JAK3 (aa 811-1124)


(Homo sapiens (Human))
BDBM410178
PNG
(US10370375, Example 26)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1c(cnc2[nH]ccc12)C#N
PDB

GoogleScholar
PC cid
PC sid
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US Patent
n/an/a 3.00E+3n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
TYK2 (aa 888-1187)


(Homo sapiens (Human))
BDBM410180
PNG
(US10370375, Example 28)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ncnn2cccc12
Show InChI InChI=1S/C15H23N5O2S/c1-16-23(21,22)10-12-5-7-13(8-6-12)19(2)15-14-4-3-9-20(14)18-11-17-15/h3-4,9,11-13,16H,5-8,10H2,1-2H3/t12-,13?
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 3.20E+3n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
JAK3 (aa 811-1124)


(Homo sapiens (Human))
BDBM410177
PNG
(US10370375, Example 25)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Oc1c(cnc2[nH]ccc12)[N+]([O-])=O
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.60E+3n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
TYK2 (aa 888-1187)


(Homo sapiens (Human))
BDBM410154
PNG
(US10370375, Example 2)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ncnc2[nH]cnc12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.59E+3n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
TYK2 (aa 888-1187)


(Homo sapiens (Human))
BDBM410153
PNG
(US10370375, Example 1)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ncnc2[nH]c(C)nc12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.51E+3n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
TYK2 (aa 888-1187)


(Homo sapiens (Human))
BDBM410165
PNG
(US10370375, Example 13)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1nc(N)ncc1Br
Show InChI InChI=1S/C12H20BrN5O2S/c1-15-21(19,20)7-8-2-4-9(5-3-8)17-11-10(13)6-16-12(14)18-11/h6,8-9,15H,2-5,7H2,1H3,(H3,14,16,17,18)/t8-,9?
PDB

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US Patent
n/an/a 6.00E+3n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
TYK2 (aa 888-1187)


(Homo sapiens (Human))
BDBM410179
PNG
(US10370375, Example 27)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1c(cnn2cccc12)C#N
Show InChI InChI=1S/C16H21N5O2S/c1-18-24(22,23)11-12-4-6-14(7-5-12)20-16-13(9-17)10-19-21-8-2-3-15(16)21/h2-3,8,10,12,14,18,20H,4-7,11H2,1H3/t12-,14?
PDB

GoogleScholar
PC cid
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US Patent
n/an/a 7.80E+3n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
JAK3 (aa 811-1124)


(Homo sapiens (Human))
BDBM410153
PNG
(US10370375, Example 1)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ncnc2[nH]c(C)nc12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.93E+3n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
TYK2 (aa 888-1187)


(Homo sapiens (Human))
BDBM410176
PNG
(US10370375, Example 24)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1c(cnn2cccc12)C#N
Show InChI InChI=1S/C17H23N5O2S/c1-19-25(23,24)12-13-5-7-15(8-6-13)21(2)17-14(10-18)11-20-22-9-3-4-16(17)22/h3-4,9,11,13,15,19H,5-8,12H2,1-2H3/t13-,15?
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8.50E+3n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (aa 866-1154)


(Homo sapiens (Human))
BDBM410157
PNG
(US10370375, Example 5)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ncnc2[nH]c(Cc3ccccc3)nc12
PDB
MMDB

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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
TYK2 (aa 888-1187)


(Homo sapiens (Human))
BDBM410175
PNG
(US10370375, Example 23)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1nc(N)ncc1-c1ccccc1
Show InChI InChI=1S/C18H25N5O2S/c1-20-26(24,25)12-13-7-9-15(10-8-13)22-17-16(11-21-18(19)23-17)14-5-3-2-4-6-14/h2-6,11,13,15,20H,7-10,12H2,1H3,(H3,19,21,22,23)/t13-,15?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
JAK3 (aa 811-1124)


(Homo sapiens (Human))
BDBM410172
PNG
(US10370375, Example 20)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Oc1c(cnc2sccc12)C#C
Show InChI InChI=1S/C17H20N2O3S2/c1-3-13-10-19-17-15(8-9-23-17)16(13)22-14-6-4-12(5-7-14)11-24(20,21)18-2/h1,8-10,12,14,18H,4-7,11H2,2H3/t12-,14?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
JAK3 (aa 811-1124)


(Homo sapiens (Human))
BDBM410155
PNG
(US10370375, Example 3)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ncnc2[nH]nnc12
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
JAK3 (aa 811-1124)


(Homo sapiens (Human))
BDBM410159
PNG
(US10370375, Example 7)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1nc(N)ncc1Br
Show InChI InChI=1S/C13H22BrN5O2S/c1-16-22(20,21)8-9-3-5-10(6-4-9)19(2)12-11(14)7-17-13(15)18-12/h7,9-10,16H,3-6,8H2,1-2H3,(H2,15,17,18)/t9-,10?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (aa 866-1154)


(Homo sapiens (Human))
BDBM410160
PNG
(US10370375, Example 8)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1ncnc2sccc12
Show InChI InChI=1S/C14H20N4O2S2/c1-15-22(19,20)8-10-2-4-11(5-3-10)18-13-12-6-7-21-14(12)17-9-16-13/h6-7,9-11,15H,2-5,8H2,1H3,(H,16,17,18)/t10-,11?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
JAK3 (aa 811-1124)


(Homo sapiens (Human))
BDBM410160
PNG
(US10370375, Example 8)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1ncnc2sccc12
Show InChI InChI=1S/C14H20N4O2S2/c1-15-22(19,20)8-10-2-4-11(5-3-10)18-13-12-6-7-21-14(12)17-9-16-13/h6-7,9-11,15H,2-5,8H2,1H3,(H,16,17,18)/t10-,11?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (aa 866-1154)


(Homo sapiens (Human))
BDBM410161
PNG
(US10370375, Example 9)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ncnc2sccc12
Show InChI InChI=1S/C15H22N4O2S2/c1-16-23(20,21)9-11-3-5-12(6-4-11)19(2)14-13-7-8-22-15(13)18-10-17-14/h7-8,10-12,16H,3-6,9H2,1-2H3/t11-,12?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
TYK2 (aa 888-1187)


(Homo sapiens (Human))
BDBM410162
PNG
(US10370375, Example 10)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1cc(Cl)nc(N)n1
Show InChI InChI=1S/C13H22ClN5O2S/c1-16-22(20,21)8-9-3-5-10(6-4-9)19(2)12-7-11(14)17-13(15)18-12/h7,9-10,16H,3-6,8H2,1-2H3,(H2,15,17,18)/t9-,10?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
TYK2 (aa 888-1187)


(Homo sapiens (Human))
BDBM410163
PNG
(US10370375, Example 11)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1ccnc(N)n1
Show InChI InChI=1S/C12H21N5O2S/c1-14-20(18,19)8-9-2-4-10(5-3-9)16-11-6-7-15-12(13)17-11/h6-7,9-10,14H,2-5,8H2,1H3,(H3,13,15,16,17)/t9-,10?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (aa 866-1154)


(Homo sapiens (Human))
BDBM410167
PNG
(US10370375, Example 15)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1ccnn2cccc12
Show InChI InChI=1S/C15H22N4O2S/c1-16-22(20,21)11-12-4-6-13(7-5-12)18-14-8-9-17-19-10-2-3-15(14)19/h2-3,8-10,12-13,16,18H,4-7,11H2,1H3/t12-,13?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
TYK2 (aa 888-1187)


(Homo sapiens (Human))
BDBM410168
PNG
(US10370375, Example 16)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ccnc(N)n1
Show InChI InChI=1S/C13H23N5O2S/c1-15-21(19,20)9-10-3-5-11(6-4-10)18(2)12-7-8-16-13(14)17-12/h7-8,10-11,15H,3-6,9H2,1-2H3,(H2,14,16,17)/t10-,11?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (aa 866-1154)


(Homo sapiens (Human))
BDBM410169
PNG
(US10370375, Example 17)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1c(cnc2sccc12)C#N
Show InChI InChI=1S/C17H22N4O2S2/c1-19-25(22,23)11-12-3-5-14(6-4-12)21(2)16-13(9-18)10-20-17-15(16)7-8-24-17/h7-8,10,12,14,19H,3-6,11H2,1-2H3/t12-,14?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
TYK2 (aa 888-1187)


(Homo sapiens (Human))
BDBM410171
PNG
(US10370375, Example 19)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1ccnc2sccc12
Show InChI InChI=1S/C15H21N3O2S2/c1-16-22(19,20)10-11-2-4-12(5-3-11)18-14-6-8-17-15-13(14)7-9-21-15/h6-9,11-12,16H,2-5,10H2,1H3,(H,17,18)/t11-,12?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (aa 866-1154)


(Homo sapiens (Human))
BDBM410156
PNG
(US10370375, Example 4)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ncnc2[nH]c(nc12)-c1ccccc1
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
JAK3 (aa 811-1124)


(Homo sapiens (Human))
BDBM410166
PNG
(US10370375, Example 14)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1c(cnc2sccc12)C#N
Show InChI InChI=1S/C16H20N4O2S2/c1-18-24(21,22)10-11-2-4-13(5-3-11)20-15-12(8-17)9-19-16-14(15)6-7-23-16/h6-7,9,11,13,18H,2-5,10H2,1H3,(H,19,20)/t11-,13?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
TYK2 (aa 888-1187)


(Homo sapiens (Human))
BDBM410166
PNG
(US10370375, Example 14)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1c(cnc2sccc12)C#N
Show InChI InChI=1S/C16H20N4O2S2/c1-18-24(21,22)10-11-2-4-13(5-3-11)20-15-12(8-17)9-19-16-14(15)6-7-23-16/h6-7,9,11,13,18H,2-5,10H2,1H3,(H,19,20)/t11-,13?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
JAK3 (aa 811-1124)


(Homo sapiens (Human))
BDBM410168
PNG
(US10370375, Example 16)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ccnc(N)n1
Show InChI InChI=1S/C13H23N5O2S/c1-15-21(19,20)9-10-3-5-11(6-4-10)18(2)12-7-8-16-13(14)17-12/h7-8,10-11,15H,3-6,9H2,1-2H3,(H2,14,16,17)/t10-,11?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
TYK2 (aa 888-1187)


(Homo sapiens (Human))
BDBM410169
PNG
(US10370375, Example 17)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1c(cnc2sccc12)C#N
Show InChI InChI=1S/C17H22N4O2S2/c1-19-25(22,23)11-12-3-5-14(6-4-12)21(2)16-13(9-18)10-20-17-15(16)7-8-24-17/h7-8,10,12,14,19H,3-6,11H2,1-2H3/t12-,14?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
JAK3 (aa 811-1124)


(Homo sapiens (Human))
BDBM410175
PNG
(US10370375, Example 23)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1nc(N)ncc1-c1ccccc1
Show InChI InChI=1S/C18H25N5O2S/c1-20-26(24,25)12-13-7-9-15(10-8-13)22-17-16(11-21-18(19)23-17)14-5-3-2-4-6-14/h2-6,11,13,15,20H,7-10,12H2,1H3,(H3,19,21,22,23)/t13-,15?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
JAK3 (aa 811-1124)


(Homo sapiens (Human))
BDBM410176
PNG
(US10370375, Example 24)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1c(cnn2cccc12)C#N
Show InChI InChI=1S/C17H23N5O2S/c1-19-25(23,24)12-13-5-7-15(8-6-13)21(2)17-14(10-18)11-20-22-9-3-4-16(17)22/h3-4,9,11,13,15,19H,5-8,12H2,1-2H3/t13-,15?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
JAK3 (aa 811-1124)


(Homo sapiens (Human))
BDBM410180
PNG
(US10370375, Example 28)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ncnn2cccc12
Show InChI InChI=1S/C15H23N5O2S/c1-16-23(21,22)10-12-5-7-13(8-6-12)19(2)15-14-4-3-9-20(14)18-11-17-15/h3-4,9,11-13,16H,5-8,10H2,1-2H3/t12-,13?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
JAK3 (aa 811-1124)


(Homo sapiens (Human))
BDBM410157
PNG
(US10370375, Example 5)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ncnc2[nH]c(Cc3ccccc3)nc12
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (aa 866-1154)


(Homo sapiens (Human))
BDBM410159
PNG
(US10370375, Example 7)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1nc(N)ncc1Br
Show InChI InChI=1S/C13H22BrN5O2S/c1-16-22(20,21)8-9-3-5-10(6-4-9)19(2)12-11(14)7-17-13(15)18-12/h7,9-10,16H,3-6,8H2,1-2H3,(H2,15,17,18)/t9-,10?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
TYK2 (aa 888-1187)


(Homo sapiens (Human))
BDBM410159
PNG
(US10370375, Example 7)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1nc(N)ncc1Br
Show InChI InChI=1S/C13H22BrN5O2S/c1-16-22(20,21)8-9-3-5-10(6-4-9)19(2)12-11(14)7-17-13(15)18-12/h7,9-10,16H,3-6,8H2,1-2H3,(H2,15,17,18)/t9-,10?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
JAK3 (aa 811-1124)


(Homo sapiens (Human))
BDBM410161
PNG
(US10370375, Example 9)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ncnc2sccc12
Show InChI InChI=1S/C15H22N4O2S2/c1-16-23(20,21)9-11-3-5-12(6-4-11)19(2)14-13-7-8-22-15(13)18-10-17-14/h7-8,10-12,16H,3-6,9H2,1-2H3/t11-,12?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (aa 866-1154)


(Homo sapiens (Human))
BDBM410163
PNG
(US10370375, Example 11)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1ccnc(N)n1
Show InChI InChI=1S/C12H21N5O2S/c1-14-20(18,19)8-9-2-4-10(5-3-9)16-11-6-7-15-12(13)17-11/h6-7,9-10,14H,2-5,8H2,1H3,(H3,13,15,16,17)/t9-,10?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
JAK3 (aa 811-1124)


(Homo sapiens (Human))
BDBM410164
PNG
(US10370375, Example 12)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1nc(N)ncc1C
Show InChI InChI=1S/C13H23N5O2S/c1-9-7-16-13(14)18-12(9)17-11-5-3-10(4-6-11)8-21(19,20)15-2/h7,10-11,15H,3-6,8H2,1-2H3,(H3,14,16,17,18)/t10-,11?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
TYK2 (aa 888-1187)


(Homo sapiens (Human))
BDBM410167
PNG
(US10370375, Example 15)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1ccnn2cccc12
Show InChI InChI=1S/C15H22N4O2S/c1-16-22(20,21)11-12-4-6-13(7-5-12)18-14-8-9-17-19-10-2-3-15(14)19/h2-3,8-10,12-13,16,18H,4-7,11H2,1H3/t12-,13?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (aa 866-1154)


(Homo sapiens (Human))
BDBM410168
PNG
(US10370375, Example 16)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ccnc(N)n1
Show InChI InChI=1S/C13H23N5O2S/c1-15-21(19,20)9-10-3-5-11(6-4-10)18(2)12-7-8-16-13(14)17-12/h7-8,10-11,15H,3-6,9H2,1-2H3,(H2,14,16,17)/t10-,11?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
TYK2 (aa 888-1187)


(Homo sapiens (Human))
BDBM410158
PNG
(US10370375, Example 6)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Oc1ncnn2cccc12
Show InChI InChI=1S/C14H20N4O3S/c1-15-22(19,20)9-11-4-6-12(7-5-11)21-14-13-3-2-8-18(13)17-10-16-14/h2-3,8,10-12,15H,4-7,9H2,1H3/t11-,12?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
TYK2 (aa 888-1187)


(Homo sapiens (Human))
BDBM410164
PNG
(US10370375, Example 12)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1nc(N)ncc1C
Show InChI InChI=1S/C13H23N5O2S/c1-9-7-16-13(14)18-12(9)17-11-5-3-10(4-6-11)8-21(19,20)15-2/h7,10-11,15H,3-6,8H2,1-2H3,(H3,14,16,17,18)/t10-,11?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
JAK3 (aa 811-1124)


(Homo sapiens (Human))
BDBM410165
PNG
(US10370375, Example 13)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1nc(N)ncc1Br
Show InChI InChI=1S/C12H20BrN5O2S/c1-15-21(19,20)7-8-2-4-9(5-3-8)17-11-10(13)6-16-12(14)18-11/h6,8-9,15H,2-5,7H2,1H3,(H3,14,16,17,18)/t8-,9?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (aa 866-1154)


(Homo sapiens (Human))
BDBM410166
PNG
(US10370375, Example 14)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1c(cnc2sccc12)C#N
Show InChI InChI=1S/C16H20N4O2S2/c1-18-24(21,22)10-11-2-4-13(5-3-11)20-15-12(8-17)9-19-16-14(15)6-7-23-16/h6-7,9,11,13,18H,2-5,10H2,1H3,(H,19,20)/t11-,13?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
JAK3 (aa 811-1124)


(Homo sapiens (Human))
BDBM410171
PNG
(US10370375, Example 19)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1ccnc2sccc12
Show InChI InChI=1S/C15H21N3O2S2/c1-16-22(19,20)10-11-2-4-12(5-3-11)18-14-6-8-17-15-13(14)7-9-21-15/h6-9,11-12,16H,2-5,10H2,1H3,(H,17,18)/t11-,12?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
JAK3 (aa 811-1124)


(Homo sapiens (Human))
BDBM410179
PNG
(US10370375, Example 27)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1c(cnn2cccc12)C#N
Show InChI InChI=1S/C16H21N5O2S/c1-18-24(22,23)11-12-4-6-14(7-5-12)20-16-13(9-17)10-19-21-8-2-3-15(16)21/h2-3,8,10,12,14,18,20H,4-7,11H2,1H3/t12-,14?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (aa 866-1154)


(Homo sapiens (Human))
BDBM410155
PNG
(US10370375, Example 3)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ncnc2[nH]nnc12
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
JAK3 (aa 811-1124)


(Homo sapiens (Human))
BDBM410156
PNG
(US10370375, Example 4)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ncnc2[nH]c(nc12)-c1ccccc1
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
TYK2 (aa 888-1187)


(Homo sapiens (Human))
BDBM410156
PNG
(US10370375, Example 4)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ncnc2[nH]c(nc12)-c1ccccc1
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
TYK2 (aa 888-1187)


(Homo sapiens (Human))
BDBM410157
PNG
(US10370375, Example 5)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ncnc2[nH]c(Cc3ccccc3)nc12
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
TYK2 (aa 888-1187)


(Homo sapiens (Human))
BDBM410161
PNG
(US10370375, Example 9)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ncnc2sccc12
Show InChI InChI=1S/C15H22N4O2S2/c1-16-23(20,21)9-11-3-5-12(6-4-11)19(2)14-13-7-8-22-15(13)18-10-17-14/h7-8,10-12,16H,3-6,9H2,1-2H3/t11-,12?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
JAK3 (aa 811-1124)


(Homo sapiens (Human))
BDBM410163
PNG
(US10370375, Example 11)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1ccnc(N)n1
Show InChI InChI=1S/C12H21N5O2S/c1-14-20(18,19)8-9-2-4-10(5-3-9)16-11-6-7-15-12(13)17-11/h6-7,9-10,14H,2-5,8H2,1H3,(H3,13,15,16,17)/t9-,10?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
TYK2 (aa 888-1187)


(Homo sapiens (Human))
BDBM410172
PNG
(US10370375, Example 20)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Oc1c(cnc2sccc12)C#C
Show InChI InChI=1S/C17H20N2O3S2/c1-3-13-10-19-17-15(8-9-23-17)16(13)22-14-6-4-12(5-7-14)11-24(20,21)18-2/h1,8-10,12,14,18H,4-7,11H2,2H3/t12-,14?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (aa 866-1154)


(Homo sapiens (Human))
BDBM410173
PNG
(US10370375, Example 21)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Oc1nc(N)ncc1-c1ccccc1
Show InChI InChI=1S/C18H24N4O3S/c1-20-26(23,24)12-13-7-9-15(10-8-13)25-17-16(11-21-18(19)22-17)14-5-3-2-4-6-14/h2-6,11,13,15,20H,7-10,12H2,1H3,(H2,19,21,22)/t13-,15?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
JAK3 (aa 811-1124)


(Homo sapiens (Human))
BDBM410173
PNG
(US10370375, Example 21)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Oc1nc(N)ncc1-c1ccccc1
Show InChI InChI=1S/C18H24N4O3S/c1-20-26(23,24)12-13-7-9-15(10-8-13)25-17-16(11-21-18(19)22-17)14-5-3-2-4-6-14/h2-6,11,13,15,20H,7-10,12H2,1H3,(H2,19,21,22)/t13-,15?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (aa 866-1154)


(Homo sapiens (Human))
BDBM410158
PNG
(US10370375, Example 6)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Oc1ncnn2cccc12
Show InChI InChI=1S/C14H20N4O3S/c1-15-22(19,20)9-11-4-6-12(7-5-11)21-14-13-3-2-8-18(13)17-10-16-14/h2-3,8,10-12,15H,4-7,9H2,1H3/t11-,12?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
JAK3 (aa 811-1124)


(Homo sapiens (Human))
BDBM410158
PNG
(US10370375, Example 6)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Oc1ncnn2cccc12
Show InChI InChI=1S/C14H20N4O3S/c1-15-22(19,20)9-11-4-6-12(7-5-11)21-14-13-3-2-8-18(13)17-10-16-14/h2-3,8,10-12,15H,4-7,9H2,1H3/t11-,12?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
TYK2 (aa 888-1187)


(Homo sapiens (Human))
BDBM410160
PNG
(US10370375, Example 8)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1ncnc2sccc12
Show InChI InChI=1S/C14H20N4O2S2/c1-15-22(19,20)8-10-2-4-11(5-3-10)18-13-12-6-7-21-14(12)17-9-16-13/h6-7,9-11,15H,2-5,8H2,1H3,(H,16,17,18)/t10-,11?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (aa 866-1154)


(Homo sapiens (Human))
BDBM410162
PNG
(US10370375, Example 10)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1cc(Cl)nc(N)n1
Show InChI InChI=1S/C13H22ClN5O2S/c1-16-22(20,21)8-9-3-5-10(6-4-9)19(2)12-7-11(14)17-13(15)18-12/h7,9-10,16H,3-6,8H2,1-2H3,(H2,15,17,18)/t9-,10?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
JAK3 (aa 811-1124)


(Homo sapiens (Human))
BDBM410167
PNG
(US10370375, Example 15)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1ccnn2cccc12
Show InChI InChI=1S/C15H22N4O2S/c1-16-22(20,21)11-12-4-6-13(7-5-12)18-14-8-9-17-19-10-2-3-15(14)19/h2-3,8-10,12-13,16,18H,4-7,11H2,1H3/t12-,13?
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n/an/a>1.00E+4n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (aa 866-1154)


(Homo sapiens (Human))
BDBM410171
PNG
(US10370375, Example 19)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1ccnc2sccc12
Show InChI InChI=1S/C15H21N3O2S2/c1-16-22(19,20)10-11-2-4-12(5-3-11)18-14-6-8-17-15-13(14)7-9-21-15/h6-9,11-12,16H,2-5,10H2,1H3,(H,17,18)/t11-,12?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
TYK2 (aa 888-1187)


(Homo sapiens (Human))
BDBM410155
PNG
(US10370375, Example 3)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1ncnc2[nH]nnc12
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n/an/a>1.00E+4n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
JAK3 (aa 811-1124)


(Homo sapiens (Human))
BDBM410162
PNG
(US10370375, Example 10)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1cc(Cl)nc(N)n1
Show InChI InChI=1S/C13H22ClN5O2S/c1-16-22(20,21)8-9-3-5-10(6-4-9)19(2)12-7-11(14)17-13(15)18-12/h7,9-10,16H,3-6,8H2,1-2H3,(H2,15,17,18)/t9-,10?
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n/an/a>1.00E+4n/an/an/an/an/an/a



Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
JAK3 (aa 811-1124)


(Homo sapiens (Human))
BDBM410169
PNG
(US10370375, Example 17)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1c(cnc2sccc12)C#N
Show InChI InChI=1S/C17H22N4O2S2/c1-19-25(22,23)11-12-3-5-14(6-4-12)21(2)16-13(9-18)10-20-17-15(16)7-8-24-17/h7-8,10,12,14,19H,3-6,11H2,1-2H3/t12-,14?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (aa 866-1154)


(Homo sapiens (Human))
BDBM410172
PNG
(US10370375, Example 20)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Oc1c(cnc2sccc12)C#C
Show InChI InChI=1S/C17H20N2O3S2/c1-3-13-10-19-17-15(8-9-23-17)16(13)22-14-6-4-12(5-7-14)11-24(20,21)18-2/h1,8-10,12,14,18H,4-7,11H2,2H3/t12-,14?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
TYK2 (aa 888-1187)


(Homo sapiens (Human))
BDBM410173
PNG
(US10370375, Example 21)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Oc1nc(N)ncc1-c1ccccc1
Show InChI InChI=1S/C18H24N4O3S/c1-20-26(23,24)12-13-7-9-15(10-8-13)25-17-16(11-21-18(19)22-17)14-5-3-2-4-6-14/h2-6,11,13,15,20H,7-10,12H2,1H3,(H2,19,21,22)/t13-,15?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (aa 866-1154)


(Homo sapiens (Human))
BDBM410175
PNG
(US10370375, Example 23)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1nc(N)ncc1-c1ccccc1
Show InChI InChI=1S/C18H25N5O2S/c1-20-26(24,25)12-13-7-9-15(10-8-13)22-17-16(11-21-18(19)23-17)14-5-3-2-4-6-14/h2-6,11,13,15,20H,7-10,12H2,1H3,(H3,19,21,22,23)/t13-,15?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (aa 866-1154)


(Homo sapiens (Human))
BDBM410164
PNG
(US10370375, Example 12)
Show SMILES CNS(=O)(=O)C[C@H]1CCC(CC1)Nc1nc(N)ncc1C
Show InChI InChI=1S/C13H23N5O2S/c1-9-7-16-13(14)18-12(9)17-11-5-3-10(4-6-11)8-21(19,20)15-2/h7,10-11,15H,3-6,8H2,1-2H3,(H3,14,16,17,18)/t10-,11?
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Elanco Tiergesundheit AG

US Patent


Assay Description
All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8...


US Patent US10370375 (2019)


BindingDB Entry DOI: 10.7270/Q2ZC857B
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%