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Patent code US10376513

Compile Data Set for Download or QSAR

Found 368 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255803
PNG
(5-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H28ClN7O2/c1-7-35-22-17(15(4)33-24-21(14(3)31-33)23(27)29-12-30-24)10-18(26)13(2)20(22)16-8-9-19(28-11-16)25(34)32(5)6/h8-12,15H,7H2,1-6H3,(H2,27,29,30)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255804
PNG
(5-{3-[1-(4-Amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidi...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(I)c2c(N)ncnc12
Show InChI InChI=1S/C24H25ClIN7O2/c1-6-35-20-15(13(3)33-23-19(21(26)31-33)22(27)29-11-30-23)9-16(25)12(2)18(20)14-7-8-17(28-10-14)24(34)32(4)5/h7-11,13H,6H2,1-5H3,(H2,27,29,30)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261178
PNG
(4-(3-(1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]pyrim...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccnc(c1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H26ClN7O2/c1-12-17(25)10-16(14(3)32-23-20(13(2)30-32)22(26)28-11-29-23)21(34-6)19(12)15-7-8-27-18(9-15)24(33)31(4)5/h7-11,14H,1-6H3,(H2,26,28,29)
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255808
PNG
(4-{3-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccnc(c1)C(=O)N(C)CCO)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H28ClN7O3/c1-13-18(26)11-17(15(3)33-24-21(14(2)31-33)23(27)29-12-30-24)22(36-5)20(13)16-6-7-28-19(10-16)25(35)32(4)8-9-34/h6-7,10-12,15,34H,8-9H2,1-5H3,(H2,27,29,30)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255814
PNG
(4-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)CCO)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H28ClN7O3/c1-13-18(26)10-17(15(3)33-24-21(14(2)31-33)23(27)29-12-30-24)22(36-5)20(13)16-6-7-19(28-11-16)25(35)32(4)8-9-34/h6-7,10-12,15,34H,8-9H2,1-5H3,(H2,27,29,30)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255820
PNG
(4-Amino-8-[1-(5-chloro-2-methoxy-4-methyl-3-pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cncnc1)C(C)n1ccc(=O)c2c(N)ncnc12
Show InChI InChI=1S/C21H19ClN6O2/c1-11-15(22)6-14(19(30-3)17(11)13-7-24-9-25-8-13)12(2)28-5-4-16(29)18-20(23)26-10-27-21(18)28/h4-10,12H,1-3H3,(H2,23,26,27)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255825
PNG
(4-Amino-8-{1-[5-chloro-3-(1-isopropylazetidin-3-yl...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(C)C)C(C)n1ccc(=O)c2c(N)ncnc12
Show InChI InChI=1S/C23H28ClN5O2/c1-12(2)28-9-15(10-28)19-13(3)17(24)8-16(21(19)31-5)14(4)29-7-6-18(30)20-22(25)26-11-27-23(20)29/h6-8,11-12,14-15H,9-10H2,1-5H3,(H2,25,26,27)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255826
PNG
(4-Amino-8-{1-[5-chloro-2-ethoxy-3-(1-isopropylazet...)
Show SMILES CCOc1c(cc(Cl)c(C)c1C1CN(C1)C(C)C)C(C)n1ccc(=O)c2c(N)ncnc12
Show InChI InChI=1S/C24H30ClN5O2/c1-6-32-22-17(9-18(25)14(4)20(22)16-10-29(11-16)13(2)3)15(5)30-8-7-19(31)21-23(26)27-12-28-24(21)30/h7-9,12-13,15-16H,6,10-11H2,1-5H3,(H2,26,27,28)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM417071
PNG
(US10376513, Example 36)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(cc1)C(=O)N(C)C)C(C)n1ccc(=O)c2c(N)ncnc12
Show InChI InChI=1S/C27H28ClN5O3/c1-6-36-24-19(16(3)33-12-11-21(34)23-25(29)30-14-31-26(23)33)13-20(28)15(2)22(24)17-7-9-18(10-8-17)27(35)32(4)5/h7-14,16H,6H2,1-5H3,(H2,29,30,31)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255835
PNG
(5-(3-(1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H25ClN8O2/c1-6-36-22-16(14(3)34-24-20(13(2)32-34)23(28)30-12-31-24)9-18(26)17(10-27)21(22)15-7-8-19(29-11-15)25(35)33(4)5/h7-9,11-12,14H,6H2,1-5H3,(H2,28,30,31)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255838
PNG
(5-(3-{1-[4-amino-3-(3-fluorophenyl)-1H-pyrazolo[3,...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(-c2cccc(F)c2)c2c(N)ncnc12
Show InChI InChI=1S/C30H29ClFN7O2/c1-6-41-27-21(13-22(31)16(2)24(27)19-10-11-23(34-14-19)30(40)38(4)5)17(3)39-29-25(28(33)35-15-36-29)26(37-39)18-8-7-9-20(32)12-18/h7-15,17H,6H2,1-5H3,(H2,33,35,36)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255839
PNG
(5-(3-{1-[4-amino-3-(1H-pyrazol-4-yl)-1H-pyrazolo[3...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(-c2cn[nH]c2)c2c(N)ncnc12
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255802
PNG
(1-{1-[5-Chloro-4-fluoro-3-(1-isopropylazetidin-3-y...)
Show SMILES COc1c(cc(Cl)c(F)c1C1CN(C1)C(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H26ClFN6O/c1-10(2)28-7-13(8-28)17-18(23)15(22)6-14(19(17)30-5)12(4)29-21-16(11(3)27-29)20(24)25-9-26-21/h6,9-10,12-13H,7-8H2,1-5H3,(H2,24,25,26)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255864
PNG
(1-{1-[5-Chloro-4-fluoro-3-(1-isopropylazetidin-3-y...)
Show SMILES COc1c(cc(Cl)c(F)c1C1CN(C1)C(C)C)C(C)n1nc(C(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C21H24ClF3N6O/c1-9(2)30-6-11(7-30)14-16(23)13(22)5-12(18(14)32-4)10(3)31-21-15(17(29-31)19(24)25)20(26)27-8-28-21/h5,8-11,19H,6-7H2,1-4H3,(H2,26,27,28)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261060
PNG
(5-(3-{1-[4-Amino-3-(hydroxymethyl)-1H-pyrazolo[3,4...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(CO)c2c(N)ncnc12
Show InChI InChI=1S/C25H28ClN7O3/c1-6-36-22-16(14(3)33-24-21(19(11-34)31-33)23(27)29-12-30-24)9-17(26)13(2)20(22)15-7-8-18(28-10-15)25(35)32(4)5/h7-10,12,14,34H,6,11H2,1-5H3,(H2,27,29,30)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261073
PNG
((2S)-1-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-...)
Show SMILES CCOc1c(cc(Cl)c(C)c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H31ClN6O2/c1-6-32-21-17(15(5)30-23-20(14(4)28-30)22(25)26-11-27-23)7-18(24)13(3)19(21)16-9-29(10-16)8-12(2)31/h7,11-12,15-16,31H,6,8-10H2,1-5H3,(H2,25,26,27)/t12-,15?/m0/s1
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261078
PNG
(1-[1-(5-Chloro-2-ethoxy-4-methyl-3-{1-[(1-methyl-1...)
Show SMILES CCOc1c(cc(Cl)c(C)c1C1CN(C1)C(=O)c1cnn(C)c1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H29ClN8O2/c1-6-36-22-18(15(4)34-24-21(14(3)31-34)23(27)28-12-29-24)7-19(26)13(2)20(22)17-10-33(11-17)25(35)16-8-30-32(5)9-16/h7-9,12,15,17H,6,10-11H2,1-5H3,(H2,27,28,29)
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n/an/a<10n/an/an/an/an/an/a



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261081
PNG
(2-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyr...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(CCO)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H27ClN6O2/c1-11-16(22)7-15(19(30-4)17(11)14-8-27(9-14)5-6-29)13(3)28-21-18(12(2)26-28)20(23)24-10-25-21/h7,10,13-14,29H,5-6,8-9H2,1-4H3,(H2,23,24,25)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261087
PNG
((2R)-2-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-...)
Show SMILES CNC(=O)[C@@H](C)N1CC(C1)c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC
Show InChI InChI=1S/C23H30ClN7O2/c1-11-17(24)7-16(13(3)31-22-19(12(2)29-31)21(25)27-10-28-22)20(33-6)18(11)15-8-30(9-15)14(4)23(32)26-5/h7,10,13-15H,8-9H2,1-6H3,(H,26,32)(H2,25,27,28)/t13?,14-/m1/s1
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261134
PNG
((2S)-2-(3-{3-[1-(4-Amino-3- methyl-1H-pyrazolo[3,4...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)[C@@H](C)CO)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H29ClN6O2/c1-11(9-30)28-7-15(8-28)18-12(2)17(23)6-16(20(18)31-5)14(4)29-22-19(13(3)27-29)21(24)25-10-26-22/h6,10-11,14-15,30H,7-9H2,1-5H3,(H2,24,25,26)/t11-,14?/m0/s1
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261146
PNG
(1-(1-(3-(2-aminopyrimidin-5-yl)-5- chloro-2-methox...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cnc(N)nc1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H21ClN8O/c1-9-14(21)5-13(17(30-4)15(9)12-6-24-20(23)25-7-12)11(3)29-19-16(10(2)28-29)18(22)26-8-27-19/h5-8,11H,1-4H3,(H2,22,26,27)(H2,23,24,25)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261147
PNG
(5-(3-(1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]pyrim...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)C#N)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H20ClN7O/c1-11-17(23)6-16(20(31-4)18(11)15-5-14(7-24)8-26-9-15)13(3)30-22-19(12(2)29-30)21(25)27-10-28-22/h5-6,8-10,13H,1-4H3,(H2,25,27,28)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261151
PNG
(5-(3-(1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)C(=O)N(C)C1CC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C26H28ClN7O2/c1-13-20(27)9-19(15(3)34-25-22(14(2)32-34)24(28)30-12-31-25)23(36-5)21(13)16-8-17(11-29-10-16)26(35)33(4)18-6-7-18/h8-12,15,18H,6-7H2,1-5H3,(H2,28,30,31)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261157
PNG
(3-(3-(1-(4-Amino-3-methyl-1H- pyrazolo[3,4-d]pyrim...)
Show SMILES COc1c(cc(Cl)c(C)c1CCC(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H27ClN6O2/c1-11-14(7-8-17(29)27(4)5)19(30-6)15(9-16(11)22)13(3)28-21-18(12(2)26-28)20(23)24-10-25-21/h9-10,13H,7-8H2,1-6H3,(H2,23,24,25)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM289204
PNG
(2-(4-(3-(1-(4-amino-3-methyl- 1H-pyrazolo[3,4-d]py...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1cnn(CC(=O)N(C)C)c1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H29ClN8O2/c1-7-35-22-17(15(4)33-24-21(14(3)30-33)23(26)27-12-28-24)8-18(25)13(2)20(22)16-9-29-32(10-16)11-19(34)31(5)6/h8-10,12,15H,7,11H2,1-6H3,(H2,26,27,28)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM417252
PNG
(US10376513, Example 210)
Show SMILES COc1c(cc(C#N)c(C)c1-c1cnn(c1)C(C)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H29N9O2/c1-13-17(9-26)8-19(15(3)34-24-21(14(2)31-34)23(27)28-12-29-24)22(36-7)20(13)18-10-30-33(11-18)16(4)25(35)32(5)6/h8,10-12,15-16H,1-7H3,(H2,27,28,29)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261192
PNG
(US10092570, Example 215 | US10376513, Example 215 ...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H28ClN7O/c1-6-32-21-16(14(5)31-23-19(13(4)29-31)22(26)27-11-28-23)7-18(24)17(8-25)20(21)15-9-30(10-15)12(2)3/h7,11-12,14-15H,6,9-10H2,1-5H3,(H2,26,27,28)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM334069
PNG
(4-[1-(4-Amino-3-methyl-1H- pyrazolo[3,4-d]pyrimidi...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(C)CO)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H28ClN7O2/c1-5-33-21-16(14(4)31-23-19(13(3)29-31)22(26)27-11-28-23)6-18(24)17(7-25)20(21)15-8-30(9-15)12(2)10-32/h6,11-12,14-15,32H,5,8-10H2,1-4H3,(H2,26,27,28)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM417297
PNG
(3-{3-[1-(4-Amino-3-methyl-1H- pyrazolo[3,4-d]pyrim...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(=O)NC(C)(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H31ClN8O2/c1-7-36-21-16(14(3)34-23-19(13(2)32-34)22(28)29-12-30-23)8-18(26)17(9-27)20(21)15-10-33(11-15)24(35)31-25(4,5)6/h8,12,14-15H,7,10-11H2,1-6H3,(H,31,35)(H2,28,29,30)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261241
PNG
(US10092570, Example 299 | US10376513, Example 307 ...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C1)C(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H26ClN7O/c1-11(2)29-8-14(9-29)19-16(7-24)17(23)6-15(20(19)31-5)13(4)30-22-18(12(3)28-30)21(25)26-10-27-22/h6,10-11,13-14H,8-9H2,1-5H3,(H2,25,26,27)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261245
PNG
(4-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(CCO)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H24ClN7O2/c1-11-17-20(24)25-10-26-21(17)29(27-11)12(2)14-6-16(22)15(7-23)18(19(14)31-3)13-8-28(9-13)4-5-30/h6,10,12-13,30H,4-5,8-9H2,1-3H3,(H2,24,25,26)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261259
PNG
(US10092570, Example 282 | US10376513, Example 282 ...)
Show SMILES CCC(=O)N1CC(C1)c1c(OC)c(cc(Cl)c1C#N)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H24ClN7O2/c1-5-17(31)29-8-13(9-29)19-15(7-24)16(23)6-14(20(19)32-4)12(3)30-22-18(11(2)28-30)21(25)26-10-27-22/h6,10,12-13H,5,8-9H2,1-4H3,(H2,25,26,27)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261265
PNG
(US10092570, Example 288 | US10376513, Example 288 ...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C1)S(=O)(=O)C1CC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H24ClN7O3S/c1-11-18-21(25)26-10-27-22(18)30(28-11)12(2)15-6-17(23)16(7-24)19(20(15)33-3)13-8-29(9-13)34(31,32)14-4-5-14/h6,10,12-14H,4-5,8-9H2,1-3H3,(H2,25,26,27)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM289304
PNG
((3-{3-[1-(4-Amino-3-methyl-1H- pyrazolo[3,4-d]pyri...)
Show SMILES COc1c(cc(Cl)c(Cl)c1C1CN(CC#N)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H21Cl2N7O/c1-10-15-19(24)25-9-26-20(15)29(27-10)11(2)13-6-14(21)17(22)16(18(13)30-3)12-7-28(8-12)5-4-23/h6,9,11-12H,5,7-8H2,1-3H3,(H2,24,25,26)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261241
PNG
(US10092570, Example 299 | US10376513, Example 307 ...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C1)C(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H26ClN7O/c1-11(2)29-8-14(9-29)19-16(7-24)17(23)6-15(20(19)31-5)13(4)30-22-18(12(3)28-30)21(25)26-10-27-22/h6,10-11,13-14H,8-9H2,1-5H3,(H2,25,26,27)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261299
PNG
(US10092570, Example 321 | US10376513, Example 328 ...)
Show SMILES CCOc1c(cc(C)c(C#N)c1C1CN(CC(C)(C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H33N7O2/c1-7-34-22-18(16(4)32-24-20(15(3)30-32)23(27)28-13-29-24)8-14(2)19(9-26)21(22)17-10-31(11-17)12-25(5,6)33/h8,13,16-17,33H,7,10-12H2,1-6H3,(H2,27,28,29)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM289318
PNG
(US10092570, Example 322 | US10376513, Example 322 ...)
Show SMILES CCOc1c(cc(C)c(C#N)c1C1CN(C1)C(=O)C(C)(C)O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H31N7O3/c1-7-35-21-17(15(4)32-23-19(14(3)30-32)22(27)28-12-29-23)8-13(2)18(9-26)20(21)16-10-31(11-16)24(33)25(5,6)34/h8,12,15-16,34H,7,10-11H2,1-6H3,(H2,27,28,29)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261308
PNG
(US10092570, Example 337 | US10376513, Example 337 ...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1-c1ccc(nc1)-c1cnn(C)n1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H23ClN10O/c1-5-37-23-16(14(3)36-25-21(13(2)33-36)24(28)30-12-31-25)8-18(26)17(9-27)22(23)15-6-7-19(29-10-15)20-11-32-35(4)34-20/h6-8,10-12,14H,5H2,1-4H3,(H2,28,30,31)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM246893
PNG
(5-{3-[1-(4-amino-3- methyl-1H-pyrazolo[3,4 d]pyrim...)
Show SMILES CCOc1c(cc(C)c(C#N)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C26H28N8O2/c1-7-36-23-18(16(4)34-25-21(15(3)32-34)24(28)30-13-31-25)10-14(2)19(11-27)22(23)17-8-9-20(29-12-17)26(35)33(5)6/h8-10,12-13,16H,7H2,1-6H3,(H2,28,30,31)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM417384
PNG
(US10376513, Example 323-2)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1[C@@H]1CNC(=O)O1)[C@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H20ClN7O3/c1-4-30-17-11(5-13(21)12(6-22)16(17)14-7-24-20(29)31-14)10(3)28-19-15(9(2)27-28)18(23)25-8-26-19/h5,8,10,14H,4,7H2,1-3H3,(H,24,29)(H2,23,25,26)/t10-,14-/m0/s1
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261324
PNG
(5-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CNC(=O)O1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C19H21ClN6O3/c1-8-12(20)5-11(16(28-4)14(8)13-6-22-19(27)29-13)10(3)26-18-15(9(2)25-26)17(21)23-7-24-18/h5,7,10,13H,6H2,1-4H3,(H,22,27)(H2,21,23,24)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261340
PNG
(5-{3-[1-(4-Amino-6-methyl-5-oxopyrido[2,3-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1cc(C)c(=O)c2c(N)ncnc12
Show InChI InChI=1S/C26H27ClN6O3/c1-13-11-33(25-21(22(13)34)24(28)30-12-31-25)15(3)17-9-18(27)14(2)20(23(17)36-6)16-7-8-19(29-10-16)26(35)32(4)5/h7-12,15H,1-6H3,(H2,28,30,31)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255844
PNG
(5-{3-[1-(4-amino-3-cyclopropyl-1H-pyrazolo[3,4-d]p...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C2CC2)c2c(N)ncnc12
Show InChI InChI=1S/C27H30ClN7O2/c1-6-37-24-18(15(3)35-26-22(25(29)31-13-32-26)23(33-35)16-7-8-16)11-19(28)14(2)21(24)17-9-10-20(30-12-17)27(36)34(4)5/h9-13,15-16H,6-8H2,1-5H3,(H2,29,31,32)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255849
PNG
(5-(3-{1-[4-amino-3-(2-aminopyrimidin-5-yl)-1H-pyra...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(-c2cnc(N)nc2)c2c(N)ncnc12
Show InChI InChI=1S/C28H29ClN10O2/c1-6-41-24-18(9-19(29)14(2)21(24)16-7-8-20(32-10-16)27(40)38(4)5)15(3)39-26-22(25(30)35-13-36-26)23(37-39)17-11-33-28(31)34-12-17/h7-13,15H,6H2,1-5H3,(H2,30,35,36)(H2,31,33,34)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255850
PNG
(5-{3-[1-(4-amino-3-{6-[(methylamino)carbonyl]pyrid...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(-c2ccc(nc2)C(=O)NC)c2c(N)ncnc12
Show InChI InChI=1S/C31H32ClN9O3/c1-7-44-27-20(12-21(32)16(2)24(27)18-8-11-23(36-13-18)31(43)40(5)6)17(3)41-29-25(28(33)37-15-38-29)26(39-41)19-9-10-22(35-14-19)30(42)34-4/h8-15,17H,7H2,1-6H3,(H,34,42)(H2,33,37,38)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255862
PNG
(2-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyr...)
Show SMILES COc1c(cc(Cl)c(F)c1C1CN(CCO)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H24ClFN6O2/c1-10-15-19(23)24-9-25-20(15)28(26-10)11(2)13-6-14(21)17(22)16(18(13)30-3)12-7-27(8-12)4-5-29/h6,9,11-12,29H,4-5,7-8H2,1-3H3,(H2,23,24,25)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261065
PNG
(3-{1-[4-Amino-3-(3-fluoro-5-hydroxyphenyl)-1H-pyra...)
Show SMILES CCNC(=O)c1c(C)c(Cl)cc(C(C)n2nc(-c3cc(O)cc(F)c3)c3c(N)ncnc23)c1OCC
Show InChI InChI=1S/C25H26ClFN6O3/c1-5-29-25(35)19-12(3)18(26)10-17(22(19)36-6-2)13(4)33-24-20(23(28)30-11-31-24)21(32-33)14-7-15(27)9-16(34)8-14/h7-11,13,34H,5-6H2,1-4H3,(H,29,35)(H2,28,30,31)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261071
PNG
(1-{1-[5-Chloro-2-ethoxy-3-(1-isopropylazetidin-3-y...)
Show SMILES CCOc1c(cc(Cl)c(C)c1C1CN(C1)C(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H31ClN6O/c1-7-31-21-17(8-18(24)13(4)19(21)16-9-29(10-16)12(2)3)15(6)30-23-20(14(5)28-30)22(25)26-11-27-23/h8,11-12,15-16H,7,9-10H2,1-6H3,(H2,25,26,27)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261079
PNG
((2S)-1-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C[C@@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H29ClN6O2/c1-11(30)7-28-8-15(9-28)18-12(2)17(23)6-16(20(18)31-5)14(4)29-22-19(13(3)27-29)21(24)25-10-26-22/h6,10-11,14-15,30H,7-9H2,1-5H3,(H2,24,25,26)/t11-,14?/m1/s1
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261090
PNG
(2-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyr...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(CO)C(F)(F)F)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H26ClF3N6O2/c1-10-15(23)5-14(12(3)32-21-18(11(2)30-32)20(27)28-9-29-21)19(34-4)17(10)13-6-31(7-13)16(8-33)22(24,25)26/h5,9,12-13,16,33H,6-8H2,1-4H3,(H2,27,28,29)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10376513 (2019)


BindingDB Entry DOI: 10.7270/Q2GQ7142
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 368 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%